# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS8 Bladder-TCC [330, 354, 460, 514, 720, 939, 1183, 1475, 1838, 888] [0.144, 0.154, 0.201, 0.224, 0.314, 0.411, 0.518, 0.647, 0.808, 1.0] [0.912, 0.95, 0.961, 0.966, 0.955, 0.952, 0.947, 0.949, 0.938, 0.91] 0.094 0.856 0.654 INC 0.68 8701 0.751 SBS8 CNS-Medullo [213, 232, 347, 368, 427, 532, 622, 763, 1029, 487] [0.168, 0.183, 0.274, 0.29, 0.337, 0.42, 0.492, 0.606, 0.821, 1.0] [0.634, 0.672, 0.707, 0.734, 0.754, 0.82, 0.847, 0.872, 0.919, 0.993] 0.087 0.832 0.638 INC 0.62 5023 0.75 SBS8 Prost-AdenoCA [287, 286, 340, 405, 498, 609, 662, 792, 959, 417] [0.267, 0.266, 0.316, 0.376, 0.463, 0.567, 0.617, 0.74, 0.898, 1.0] [0.915, 0.937, 0.948, 0.945, 0.933, 0.941, 0.943, 0.937, 0.919, 0.919] 0.085 0.734 0.632 INC 0.68 5296 0.753 SBS8 Stomach-AdenoCA [131, 158, 217, 240, 294, 341, 391, 411, 413, 200] [0.254, 0.306, 0.42, 0.465, 0.57, 0.663, 0.76, 0.801, 0.806, 1.0] [0.776, 0.879, 0.9, 0.909, 0.914, 0.914, 0.931, 0.924, 0.92, 0.92] 0.079 0.746 0.501 INC 0.71 2804 0.754 SBS8 Breast-Cancer [1574, 1861, 2059, 2412, 2715, 3163, 3478, 3849, 4442, 1851] [0.329, 0.389, 0.431, 0.505, 0.568, 0.664, 0.73, 0.81, 0.937, 1.0] [0.989, 0.975, 0.972, 0.975, 0.968, 0.965, 0.95, 0.947, 0.949, 0.933] 0.076 0.671 0.548 INC 0.67 27404 0.753 SBS8 ESCC [1585, 1858, 2308, 2708, 3683, 4536, 5297, 5960, 7434, 3688] [0.166, 0.195, 0.242, 0.285, 0.387, 0.478, 0.558, 0.63, 0.787, 1.0] [0.902, 0.958, 0.985, 0.981, 0.983, 0.976, 0.977, 0.969, 0.957, 0.966] 0.088 0.834 0.592 INC 0.68 39108 0.75 SBS8 Lymph-CLL [217, 286, 351, 455, 571, 693, 999, 1368, 1966, 1028] [0.083, 0.109, 0.134, 0.174, 0.218, 0.266, 0.384, 0.527, 0.759, 1.0] [0.727, 0.796, 0.844, 0.874, 0.877, 0.883, 0.904, 0.901, 0.922, 0.995] 0.094 0.917 0.65 INC 0.71 8042 0.754 SBS8 Panc-Endocrine [485, 509, 648, 720, 858, 1034, 1203, 1262, 1493, 585] [0.321, 0.337, 0.429, 0.477, 0.568, 0.687, 0.799, 0.841, 0.997, 1.0] [0.919, 0.934, 0.948, 0.951, 0.957, 0.961, 0.961, 0.967, 0.931, 0.916] 0.084 0.679 0.66 INC 0.56 8828 0.753 SBS8 ACROSS_ALL_CANCER_TYPES [0.216, 0.242, 0.306, 0.35, 0.428, 0.52, 0.607, 0.7, 0.852, 1.0] [0.847, 0.888, 0.908, 0.917, 0.918, 0.927, 0.933, 0.933, 0.932, 0.944] 8 0 0 8