# Only cancer types with minimum 2000 mutations for SBS signatures with average probability at least 0.75 are considered. signature cancer_type processive_group_length number_of_processive_groups log10_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_number_of_processive_groups SBS8 Bladder-TCC 2 182 5.204 0.48 44.0 85.0 65.73 8.976 6.027331991007738e-38 8.219089078646916e-38 37.085 [85, 47, 53, 70, 63, 68, 54, 78, 83, 63, 59, 48, 65, 78, 57, 59, 57, 60, 64, 65, 75, 57, 71, 68, 66, 64, 63, 69, 58, 56, 76, 71, 56, 69, 62, 59, 68, 68, 79, 80, 60, 76, 68, 52, 56, 50, 61, 72, 78, 76, 61, 54, 78, 73, 53, 63, 77, 72, 70, 74, 55, 71, 58, 73, 55, 62, 62, 61, 59, 70, 74, 57, 64, 64, 56, 78, 72, 75, 74, 75, 75, 73, 54, 70, 81, 67, 58, 44, 69, 56, 81, 70, 61, 71, 71, 49, 67, 67, 69, 70] SBS8 Bladder-TCC 3 4 1.386 0.128 1.0 4.0 1.208 0.538 1.9101072963646372e-07 2.0465435318192546e-07 6.689 [1, 1, 1, 1, 4, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 2, 1, 2, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 2, 1] SBS8 Bladder-TCC 4 1 0.0 0.0 inf [] SBS8 CNS-Medullo 2 19 2.944 0.48 1.0 11.0 5.155 2.179 1.6078619305168446e-10 2.813758378404478e-10 9.551 [6, 10, 5, 1, 5, 4, 8, 9, 4, 3, 4, 2, 6, 4, 6, 7, 3, 1, 9, 1, 2, 6, 4, 8, 4, 7, 3, 8, 3, 7, 6, 4, 4, 7, 3, 5, 2, 8, 6, 7, 5, 4, 3, 4, 3, 3, 7, 6, 3, 5, 4, 5, 7, 11, 6, 2, 4, 3, 7, 5, 3, 5, 10, 6, 3, 9, 4, 5, 5, 1, 5, 6, 4, 5, 5, 6, 3, 7, 7, 5, 6, 9, 7, 7, 6, 4, 2, 4, 7, 4, 7, 4, 4, 7, 3, 9, 7] SBS8 Prost-AdenoCA 2 53 3.97 0.48 1.0 15.0 6.11 2.416 1.4239801377241508e-82 2.135970206586227e-82 81.67 [6, 9, 7, 5, 5, 6, 6, 7, 5, 5, 7, 4, 9, 8, 4, 8, 7, 6, 3, 8, 7, 7, 6, 8, 11, 6, 9, 8, 7, 7, 6, 4, 3, 4, 10, 5, 5, 9, 6, 11, 6, 11, 8, 5, 12, 15, 4, 3, 7, 6, 5, 4, 4, 3, 5, 4, 5, 4, 4, 6, 7, 6, 6, 5, 9, 6, 12, 5, 5, 1, 4, 5, 6, 3, 7, 7, 5, 8, 7, 6, 2, 1, 7, 4, 3, 5, 7, 6, 7, 4, 6, 9, 2, 2, 7, 5, 6, 8, 5, 10] SBS8 Stomach-AdenoCA 2 19 2.944 0.48 2.0 15.0 7.3 2.958 4.50217497671274e-05 6.00289996895032e-05 4.222 [7, 9, 10, 15, 8, 8, 4, 9, 13, 6, 7, 3, 4, 6, 9, 5, 3, 6, 6, 3, 7, 15, 8, 10, 5, 5, 11, 7, 8, 11, 10, 7, 8, 7, 12, 7, 8, 6, 6, 9, 2, 5, 4, 5, 8, 8, 8, 12, 2, 10, 5, 8, 6, 6, 11, 11, 9, 10, 4, 7, 4, 6, 12, 8, 2, 3, 2, 4, 7, 7, 4, 4, 12, 7, 7, 7, 6, 8, 9, 6, 9, 12, 6, 6, 12, 9, 15, 10, 3, 8, 6, 6, 4, 10, 4, 8, 9, 9, 3, 7] SBS8 Breast-Cancer 2 260 5.561 0.48 81.0 124.0 104.73 9.921 1.8565742675018737e-54 3.122420358980423e-54 53.506 [109, 108, 108, 103, 120, 107, 120, 101, 85, 108, 102, 107, 103, 116, 102, 88, 81, 86, 101, 111, 104, 95, 95, 124, 115, 100, 113, 106, 97, 106, 109, 110, 116, 114, 92, 105, 120, 103, 102, 102, 110, 102, 104, 87, 99, 100, 97, 104, 115, 123, 122, 99, 101, 105, 88, 107, 102, 109, 95, 89, 119, 113, 85, 116, 114, 98, 96, 94, 92, 107, 115, 108, 97, 101, 121, 85, 98, 103, 112, 115, 92, 111, 114, 103, 93, 119, 109, 110, 98, 117, 90, 113, 94, 100, 119, 118, 107, 102, 109, 114] SBS8 Breast-Cancer 4 1 0.0 0.0 inf [] SBS8 ESCC 2 239 5.476 0.48 71.0 119.0 93.08 10.082 7.22806088031718e-47 1.711909155864595e-46 45.767 [85, 88, 89, 97, 90, 92, 95, 101, 98, 93, 107, 88, 110, 82, 102, 113, 85, 113, 82, 83, 106, 96, 102, 96, 100, 96, 84, 104, 86, 93, 103, 88, 92, 84, 84, 93, 92, 73, 85, 100, 82, 93, 92, 97, 71, 119, 96, 76, 89, 84, 88, 73, 80, 94, 101, 104, 80, 92, 93, 89, 113, 99, 91, 87, 113, 91, 82, 95, 90, 103, 90, 88, 87, 111, 76, 100, 118, 88, 107, 89, 99, 100, 97, 82, 97, 92, 109, 87, 90, 78, 90, 96, 87, 100, 83, 90, 104, 99, 90, 77] SBS8 ESCC 3 2 0.693 0.061 1.0 3.0 1.261 0.529 0.09046445354934267 0.10712895815053737 0.97 [1, 1, 1, 1, 1, 2, 2, 2, 1, 1, 1, 1, 1, 3, 1, 1, 1, 2, 1, 1, 1, 1, 1] SBS8 Lymph-CLL 2 2 0.301 0.48 1.0 4.0 1.635 0.798 0.32600692304294177 0.8345366488286836 0.079 [1, 2, 1, 3, 2, 1, 1, 2, 2, 2, 1, 1, 3, 1, 2, 1, 1, 2, 1, 2, 2, 1, 2, 1, 1, 1, 2, 1, 2, 1, 1, 1, 4, 1, 2, 2, 2, 1, 3, 1, 2, 1, 1, 1, 1, 2, 3, 3, 3, 1, 1, 3, 1, 2, 1, 2, 1, 1, 1, 1, 3, 1, 1, 1, 2, 1, 2, 2, 1, 1, 2, 1, 4, 3] SBS8 Panc-Endocrine 2 82 4.407 0.48 13.0 39.0 23.39 4.779 3.151894674388076e-34 8.104872019855053e-34 33.091 [16, 20, 21, 18, 21, 18, 20, 34, 22, 26, 26, 24, 19, 17, 25, 13, 20, 32, 28, 23, 26, 23, 23, 25, 20, 26, 24, 26, 19, 25, 25, 26, 30, 23, 16, 28, 22, 19, 26, 17, 29, 18, 26, 16, 20, 24, 25, 23, 28, 33, 22, 27, 30, 13, 20, 26, 19, 22, 25, 24, 30, 25, 27, 22, 24, 21, 21, 23, 20, 17, 32, 22, 22, 25, 17, 28, 19, 21, 18, 26, 18, 26, 23, 24, 30, 28, 26, 21, 18, 28, 25, 28, 15, 39, 18, 28, 27, 26, 17, 32] SBS8 Panc-Endocrine 3 3 1.099 0.12 1.0 2.0 1.1 0.3 5.0596957075444555e-09 8.279502066890927e-09 8.082 [1, 1, 2, 1, 1, 1, 1, 1, 1, 1] signature cancer_type processive_group_length avg_number_of_processive_groups log10_avg_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_avg_number_of_processive_groups SBS8 ACROSS_ALL_CANCER_TYPES 2 107.0 2.029 0.48 32.125 42.625 38.391 2.18 2.0886800363938028e-213 4.1773600727876055e-213 212.379 [39.375, 36.625, 36.75, 39.0, 39.25, 38.0, 38.5, 42.625, 39.0, 38.25, 39.125, 34.625, 39.875, 39.0, 38.375, 36.75, 32.125, 38.25, 36.75, 37.0, 41.125, 37.5, 38.875, 42.5, 40.25, 38.125, 38.625, 41.125, 35.0, 38.25, 42.0, 38.875, 39.125, 38.625, 35.125, 38.0, 39.875, 35.875, 39.125, 40.875, 37.0, 38.75, 38.25, 33.375, 33.75, 40.125, 37.625, 37.375, 40.625, 42.25, 38.5, 34.125, 38.375, 38.375, 35.625, 39.875, 37.125, 39.125, 37.375, 36.875, 41.75, 40.75, 36.25, 39.75, 40.25, 36.375, 35.125, 36.125, 34.875, 38.375, 40.75, 36.375, 37.0, 39.875, 36.329, 39.079, 40.329, 38.954, 41.954, 40.454, 37.829, 41.704, 38.704, 37.204, 40.454, 40.704, 40.954, 35.454, 36.704, 37.079, 38.329, 40.954, 33.579, 41.329, 38.329, 38.579, 41.079, 39.724, 37.474, 39.599] SBS8 ACROSS_ALL_CANCER_TYPES 3 3.0 0.477 0.113 1.0 2.0 1.19 0.139 3.5648612584772066e-38 3.5648612584772066e-38 37.448 [1.0, 1.0, 1.333, 1.0, 2.0, 1.333, 1.333, 1.333, 1.0, 1.0, 1.033, 1.033, 1.033, 1.7, 1.033, 1.033, 1.367, 1.367, 1.367, 1.033, 1.033, 1.033, 1.033, 1.12, 1.12, 1.12, 1.12, 1.12, 1.12, 1.454, 1.12, 1.12, 1.454, 1.12, 1.454, 1.12, 1.12, 1.12, 1.12, 1.12, 1.12, 1.12, 1.454, 1.12, 1.12, 1.12, 1.454, 1.12, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19, 1.19] SBS8 ACROSS_ALL_CANCER_TYPES 4 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 inf [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0]