# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
signature	cancer_type	dna_element	encode_element_list	fold_change_list	avg_fold_change	p_value_list	combined_p_value	q_value
SBS8	Breast-Cancer	H2AFZ-human	['ENCFF207FTX_mammary-epithelial-cell_Normal_H2AFZ-human']	[0.885]	0.885	[8.059131818925592e-07]	8.059131818925594e-07	2.2505741476868633e-06
SBS8	Breast-Cancer	H3K27ac-human	['ENCFF154XFN_breast-epithelium_Normal_H3K27ac-human', 'ENCFF360PVA_mammary-epithelial-cell_Normal_H3K27ac-human']	[0.907, 1.047]	0.977	[0.00017061590589405448, 0.10171069135986147]	0.00020757722521962967	0.000489535226286244
SBS8	Breast-Cancer	H3K27me3-human	['ENCFF361SYZ_breast-epithelium_Normal_H3K27me3-human', 'ENCFF028RTA_mammary-epithelial-cell_Normal_H3K27me3-human', 'ENCFF755ZGR_myoepithelial-cell-of-mammary-gland_Normal_H3K27me3-human', 'ENCFF184MTO_luminal-epithelial-cell-of-mammary-gland_Normal_H3K27me3-human']	[0.974, 0.984, 0.946, 0.995]	0.975	[0.013484991822532853, 0.5327239481573831, 0.003025902419945748, 0.7579873349791683]	0.00486585853506446	0.009713995420937737
SBS8	Breast-Cancer	H3K36me3-human	['ENCFF906MJM_breast-epithelium_Normal_H3K36me3-human', 'ENCFF416PHD_mammary-epithelial-cell_Normal_H3K36me3-human', 'ENCFF841TBU_myoepithelial-cell-of-mammary-gland_Normal_H3K36me3-human', 'ENCFF220HJF_luminal-epithelial-cell-of-mammary-gland_Normal_H3K36me3-human', 'ENCFF774HHX_mammary-stem-cell_Normal_H3K36me3-human']	[0.968, 0.966, 0.984, 0.968, 0.986]	0.974	[0.005062019826241761, 0.001234882689425078, 0.1083882422101413, 0.0026467460749060824, 0.2617105323049925]	5.056649571410201e-06	1.3606146146915106e-05
SBS8	Breast-Cancer	H3K4me1-human	['ENCFF609RVI_mammary-epithelial-cell_Normal_H3K4me1-human', 'ENCFF513VGQ_myoepithelial-cell-of-mammary-gland_Normal_H3K4me1-human', 'ENCFF361XJL_luminal-epithelial-cell-of-mammary-gland_Normal_H3K4me1-human']	[0.991, 0.975, 0.991]	0.986	[0.4377602469386318, 0.02035748608644581, 0.5125523793757656]	0.09550180428760406	0.14698773487827388
SBS8	Breast-Cancer	H3K4me2-human	['ENCFF908LTV_mammary-epithelial-cell_Normal_H3K4me2-human']	[0.86]	0.86	[3.1090670406725065e-17]	3.109067040672502e-17	1.2583850458924463e-16
SBS8	Breast-Cancer	H3K4me3-human	['ENCFF065TIH_breast-epithelium_Normal_H3K4me3-human', 'ENCFF014CWM_mammary-epithelial-cell_Normal_H3K4me3-human', 'ENCFF737CON_mammary-epithelial-cell_Normal_H3K4me3-human', 'ENCFF274LUW_mammary-epithelial-cell_Normal_H3K4me3-human', 'ENCFF920PYM_myoepithelial-cell-of-mammary-gland_Normal_H3K4me3-human']	[0.916, 0.922, 0.905, 0.863, 0.905]	0.902	[0.0022710530533748686, 0.011935636798290761, 4.372941080236142e-05, 4.1349369740858846e-06, 0.00048599648303875113]	2.97693845895344e-13	1.077595553490976e-12
SBS8	Breast-Cancer	H3K79me2-human	['ENCFF695AAZ_mammary-epithelial-cell_Normal_H3K79me2-human']	[0.984]	0.984	[0.3071852174097104]	0.30718521740971033	0.4013175618662099
SBS8	Breast-Cancer	H3K9ac-human	['ENCFF691HWQ_mammary-epithelial-cell_Normal_H3K9ac-human', 'ENCFF807QVF_myoepithelial-cell-of-mammary-gland_Normal_H3K9ac-human']	[0.948, 0.91]	0.929	[0.11223661938603217, 3.2004825403301848e-06]	5.689675920292941e-06	1.5234673067804616e-05
SBS8	Breast-Cancer	H3K9me3-human	['ENCFF007JDR_breast-epithelium_Normal_H3K9me3-human', 'ENCFF851QJD_mammary-epithelial-cell_Normal_H3K9me3-human', 'ENCFF175QHZ_myoepithelial-cell-of-mammary-gland_Normal_H3K9me3-human', 'ENCFF051ACX_luminal-epithelial-cell-of-mammary-gland_Normal_H3K9me3-human']	[0.955, 0.97, 0.971, 0.99]	0.972	[0.00040932787525212324, 0.012555202674931853, 0.10149985296153857, 0.4242274281410686]	0.00016230472205071823	0.00038632954001774556
SBS8	CNS-Medullo	H3K27ac-human	['ENCFF683NWP_caudate-nucleus_Normal_H3K27ac-human', 'ENCFF244CUD_layer-of-hippocampus_Normal_H3K27ac-human', 'ENCFF580NGD_cingulate-gyrus_Normal_H3K27ac-human', 'ENCFF783KFR_substantia-nigra_Normal_H3K27ac-human']	[0.912, 0.879, 0.952, 0.919]	0.915	[0.23737833604801994, 0.024680028058778416, 0.3843623328412227, 0.29464483909713013]	0.06662116830756654	0.10709066727948588
SBS8	CNS-Medullo	H3K27me3-human	['ENCFF741YLR_brain_Normal_H3K27me3-human']	[0.903]	0.903	[0.05395848830075035]	0.05395848830075035	0.08897237628275852
SBS8	CNS-Medullo	H3K36me3-human	['ENCFF863DFK_germinal-matrix_Normal_H3K36me3-human']	[0.913]	0.913	[0.0001760306390322959]	0.00017603063903229578	0.0004182226389888043
SBS8	CNS-Medullo	H3K9ac-human	['ENCFF160APM_astrocyte_Normal_H3K9ac-human']	[0.792]	0.792	[0.01192479729786772]	0.01192479729786773	0.022528531379575816
SBS8	CNS-Medullo	H3K9me3-human	['ENCFF013EFU_brain_Normal_H3K9me3-human', 'ENCFF197DHO_germinal-matrix_Normal_H3K9me3-human']	[1.103, 1.081]	1.092	[0.0020646639100747135, 0.08217961257871666]	0.001642714912893117	0.0034900869993194296
SBS8	ESCC	H3K27ac-human	['ENCFF683MJC_esophagus-squamous-epithelium_Normal_H3K27ac-human']	[0.955]	0.955	[0.021048454955324782]	0.02104845495532478	0.03802397441788191
SBS8	ESCC	H3K36me3-human	['ENCFF848QKQ_esophagus-squamous-epithelium_Normal_H3K36me3-human']	[0.979]	0.979	[0.0008804602046625498]	0.0008804602046625499	0.0019304718887372596
SBS8	ESCC	H3K4me1-human	['ENCFF353HXQ_esophagus-squamous-epithelium_Normal_H3K4me1-human']	[0.979]	0.979	[0.006120247137897714]	0.006120247137897709	0.012067517095639009
SBS8	ESCC	H3K4me3-human	['ENCFF565PHW_epithelial-cell-of-esophagus_Normal_H3K4me3-human', 'ENCFF518WBH_esophagus-squamous-epithelium_Normal_H3K4me3-human']	[0.957, 0.908]	0.932	[0.029903788810974278, 2.0429882006623997e-05]	9.352302156269289e-06	2.451146405300906e-05
SBS8	ESCC	H3K9me3-human	['ENCFF164KXT_esophagus-squamous-epithelium_Normal_H3K9me3-human']	[0.923]	0.923	[1.9631278572727308e-07]	1.9631278572727314e-07	5.672079509303817e-07
SBS8	Lymph-CLL	H2AFZ-human	['ENCFF514BDZ_B-cell_Normal_H2AFZ-human']	[0.946]	0.946	[0.2749857119195186]	0.2749857119195186	0.36333339415812427
SBS8	Lymph-CLL	H3K27ac-human	['ENCFF884VAH_B-cell_Normal_H3K27ac-human']	[0.821]	0.821	[0.0038963725488508627]	0.0038963725488508644	0.007876913313983543
SBS8	Lymph-CLL	H3K4me1-human	['ENCFF531GRE_B-cell_Normal_H3K4me1-human']	[0.899]	0.899	[1.4929042447848227e-05]	1.4929042447848219e-05	3.8239476550329516e-05
SBS8	Lymph-CLL	H3K4me2-human	['ENCFF900JSN_B-cell_Normal_H3K4me2-human']	[0.883]	0.883	[0.0028876663756579385]	0.00288766637565794	0.005966599829509702
SBS8	Lymph-CLL	H3K9ac-human	['ENCFF520FRP_B-cell_Normal_H3K9ac-human']	[0.939]	0.939	[0.23347598849538032]	0.2334759884953803	0.317338777136654
SBS8	Lymph-CLL	H3K9me3-human	['ENCFF257ZHZ_B-cell_Normal_H3K9me3-human']	[1.033]	1.033	[0.4235050846838544]	0.4235050846838545	0.5228407367863416
SBS8	Lymph-CLL	H4K20me1-human	['ENCFF676OTA_B-cell_Normal_H4K20me1-human']	[1.074]	1.074	[0.017122159820102487]	0.017122159820102484	0.03150970130922457
SBS8	Panc-Endocrine	H3K27ac-human	['ENCFF883GJY_body-of-pancreas_Normal_H3K27ac-human']	[0.785]	0.785	[3.253616116706134e-07]	3.253616116706131e-07	9.261220355935775e-07
SBS8	Panc-Endocrine	H3K36me3-human	['ENCFF544VYY_pancreas_Normal_H3K36me3-human']	[0.928]	0.928	[0.025030082624534548]	0.02503008262453454	0.04444258539117956
SBS8	Panc-Endocrine	H3K4me1-human	['ENCFF379TWQ_body-of-pancreas_Normal_H3K4me1-human', 'ENCFF668HLF_pancreas_Normal_H3K4me1-human', 'ENCFF617DPF_endocrine-pancreas_Normal_H3K4me1-human']	[0.968, 0.935, 0.919]	0.941	[0.07298293502442064, 0.03050764976633858, 0.0042211805125821995]	0.0007477978247217541	0.0016537753622232682
SBS8	Panc-Endocrine	H3K4me3-human	['ENCFF549AXA_endocrine-pancreas_Normal_H3K4me3-human']	[0.915]	0.915	[0.27470025732649306]	0.2747002573264931	0.36320637055884014
SBS8	Prost-AdenoCA	H3K27ac-human	['ENCFF300WCK_epithelial-cell-of-prostate_Normal_H3K27ac-human']	[0.986]	0.986	[0.848788691474005]	0.848788691474005	0.8939890774597193
SBS8	Stomach-AdenoCA	H3K27ac-human	['ENCFF700ONQ_gastroesophageal-sphincter_Normal_H3K27ac-human']	[0.636]	0.636	[2.169432495956386e-05]	2.1694324959563875e-05	5.50536540144488e-05
SBS8	Stomach-AdenoCA	H3K27me3-human	['ENCFF503ERU_gastroesophageal-sphincter_Normal_H3K27me3-human']	[0.909]	0.909	[0.15011210693055008]	0.15011210693055008	0.21767957456255504
SBS8	Stomach-AdenoCA	H3K4me1-human	['ENCFF324NLX_stomach_Normal_H3K4me1-human']	[0.928]	0.928	[0.006221111892998538]	0.006221111892998537	0.012253802019217344