# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 88.543 E:A[C>A]A 88.556 A:A[C>G]A 55.353 E:A[C>G]A 61.102 A:A[C>T]A 9.056 E:A[C>T]A 9.403 A:A[T>A]A 1043.412 E:A[T>A]A 1104.301 A:A[T>C]A 331.691 E:A[T>C]A 319.639 A:A[T>G]A 329.004 E:A[T>G]A 309.562 A:A[C>A]C 7.466 E:A[C>A]C 8.947 A:A[C>G]C 28.828 E:A[C>G]C 27.04 A:A[C>T]C 12.306 E:A[C>T]C 12.444 A:A[T>A]C 81.876 E:A[T>A]C 87.818 A:A[T>C]C 124.982 E:A[T>C]C 114.412 A:A[T>G]C 49.151 E:A[T>G]C 47.758 A:A[C>A]G 2.404 E:A[C>A]G 2.846 A:A[C>G]G 3.919 E:A[C>G]G 3.752 A:A[C>T]G 3.681 E:A[C>T]G 4.5 A:A[T>A]G 240.288 E:A[T>A]G 229.827 A:A[T>C]G 39.314 E:A[T>C]G 38.963 A:A[T>G]G 51.368 E:A[T>G]G 51.87 A:A[C>A]T 32.838 E:A[C>A]T 36.458 A:A[C>G]T 130.929 E:A[C>G]T 121.268 A:A[C>T]T 40.254 E:A[C>T]T 40.065 A:A[T>A]T 544.239 E:A[T>A]T 498.254 A:A[T>C]T 543.148 E:A[T>C]T 511.574 A:A[T>G]T 47.857 E:A[T>G]T 51.322 A:C[C>A]A 43.562 E:C[C>A]A 41.967 A:C[C>G]A 18.12 E:C[C>G]A 16.67 A:C[C>T]A 9.608 E:C[C>T]A 9.862 A:C[T>A]A 209.377 E:C[T>A]A 217.653 A:C[T>C]A 101.846 E:C[T>C]A 104.405 A:C[T>G]A 45.95 E:C[T>G]A 42.221 A:C[C>A]C 3.154 E:C[C>A]C 3.906 A:C[C>G]C 2.54 E:C[C>G]C 2.279 A:C[C>T]C 2.169 E:C[C>T]C 2.11 A:C[T>A]C 20.526 E:C[T>A]C 19.948 A:C[T>C]C 57.38 E:C[T>C]C 59.383 A:C[T>G]C 36.432 E:C[T>G]C 32.657 A:C[C>A]G 0.558 E:C[C>A]G 0.383 A:C[C>G]G 0.253 E:C[C>G]G 0.084 A:C[C>T]G 0.117 E:C[C>T]G 0.116 A:C[T>A]G 6.854 E:C[T>A]G 6.157 A:C[T>C]G 9.304 E:C[T>C]G 7.773 A:C[T>G]G 13.584 E:C[T>G]G 13.695 A:C[C>A]T 11.739 E:C[C>A]T 12.291 A:C[C>G]T 6.508 E:C[C>G]T 5.596 A:C[C>T]T 14.857 E:C[C>T]T 15.041 A:C[T>A]T 132.006 E:C[T>A]T 117.536 A:C[T>C]T 205.956 E:C[T>C]T 201.533 A:C[T>G]T 24.335 E:C[T>G]T 24.061 A:G[C>A]A 14.024 E:G[C>A]A 14.488 A:G[C>G]A 24.07 E:G[C>G]A 23.45 A:G[C>T]A 7.554 E:G[C>T]A 7.601 A:G[T>A]A 312.995 E:G[T>A]A 293.079 A:G[T>C]A 194.126 E:G[T>C]A 198.026 A:G[T>G]A 137.278 E:G[T>G]A 129.37 A:G[C>A]C 4.402 E:G[C>A]C 4.651 A:G[C>G]C 58.06 E:G[C>G]C 64.932 A:G[C>T]C 3.813 E:G[C>T]C 3.797 A:G[T>A]C 18.108 E:G[T>A]C 18.455 A:G[T>C]C 88.439 E:G[T>C]C 91.127 A:G[T>G]C 7.915 E:G[T>G]C 7.659 A:G[C>A]G 2.95 E:G[C>A]G 2.907 A:G[C>G]G 0.213 E:G[C>G]G 0.255 A:G[C>T]G 0.897 E:G[C>T]G 0.857 A:G[T>A]G 81.623 E:G[T>A]G 75.732 A:G[T>C]G 64.134 E:G[T>C]G 57.077 A:G[T>G]G 21.692 E:G[T>G]G 19.38 A:G[C>A]T 7.835 E:G[C>A]T 9.129 A:G[C>G]T 46.549 E:G[C>G]T 50.923 A:G[C>T]T 52.198 E:G[C>T]T 54.312 A:G[T>A]T 157.989 E:G[T>A]T 139.381 A:G[T>C]T 384.986 E:G[T>C]T 343.781 A:G[T>G]T 51.211 E:G[T>G]T 43.795 A:T[C>A]A 23.146 E:T[C>A]A 23.26 A:T[C>G]A 15.273 E:T[C>G]A 13.464 A:T[C>T]A 61.677 E:T[C>T]A 58.387 A:T[T>A]A 562.421 E:T[T>A]A 550.467 A:T[T>C]A 247.603 E:T[T>C]A 245.868 A:T[T>G]A 108.927 E:T[T>G]A 95.436 A:T[C>A]C 2.281 E:T[C>A]C 3.254 A:T[C>G]C 37.986 E:T[C>G]C 35.607 A:T[C>T]C 23.088 E:T[C>T]C 22.486 A:T[T>A]C 76.225 E:T[T>A]C 74.827 A:T[T>C]C 192.498 E:T[T>C]C 188.74 A:T[T>G]C 64.286 E:T[T>G]C 61.116 A:T[C>A]G 0.0 E:T[C>A]G 0.0 A:T[C>G]G 1.188 E:T[C>G]G 0.816 A:T[C>T]G 0.778 E:T[C>T]G 0.984 A:T[T>A]G 89.727 E:T[T>A]G 91.333 A:T[T>C]G 45.897 E:T[T>C]G 41.05 A:T[T>G]G 37.493 E:T[T>G]G 35.161 A:T[C>A]T 20.42 E:T[C>A]T 19.369 A:T[C>G]T 106.55 E:T[C>G]T 100.393 A:T[C>T]T 366.628 E:T[C>T]T 352.085 A:T[T>A]T 491.974 E:T[T>A]T 441.749 A:T[T>C]T 874.789 E:T[T>C]T 835.294 A:T[T>G]T 158.554 E:T[T>G]T 138.532 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Lymph-BNHL SBS85 C>A 6.0 7.0 6.26 6.86 1.0 1.0 0.103 12633.0 Leading 1.167 1.096 1.065 6.0 6.26 3.0 11.0 [4.0, 5.0, 10.0, 7.0, 5.0, 8.0, 8.0, 7.0, 6.0, 7.0, 10.0, 6.0, 8.0, 3.0, 8.0, 6.0, 5.0, 6.0, 3.0, 5.0, 4.0, 7.0, 7.0, 4.0, 4.0, 6.0, 7.0, 6.0, 7.0, 7.0, 5.0, 6.0, 8.0, 7.0, 7.0, 6.0, 5.0, 5.0, 6.0, 9.0, 6.0, 6.0, 4.0, 7.0, 6.0, 4.0, 6.0, 9.0, 9.0, 8.0, 3.0, 4.0, 6.0, 6.0, 11.0, 6.0, 6.0, 4.0, 6.0, 5.0, 7.0, 8.0, 6.0, 10.0, 6.0, 6.0, 6.0, 8.0, 6.0, 7.0, 9.0, 5.0, 6.0, 5.0, 6.0, 8.0, 8.0, 8.0, 6.0, 5.0, 7.0, 6.0, 8.0, 8.0, 9.0, 4.0, 6.0, 3.0, 7.0, 5.0, 6.0, 4.0, 8.0, 3.0, 4.0, 6.0, 8.0, 6.0, 3.0, 7.0] 7.0 6.86 2.0 11.0 [9.0, 9.0, 3.0, 6.0, 7.0, 6.0, 6.0, 5.0, 7.0, 5.0, 4.0, 8.0, 6.0, 11.0, 6.0, 8.0, 8.0, 6.0, 11.0, 7.0, 9.0, 3.0, 6.0, 10.0, 7.0, 6.0, 6.0, 8.0, 7.0, 6.0, 8.0, 5.0, 6.0, 6.0, 7.0, 5.0, 9.0, 7.0, 6.0, 3.0, 7.0, 8.0, 10.0, 6.0, 8.0, 10.0, 8.0, 4.0, 2.0, 6.0, 8.0, 10.0, 8.0, 8.0, 3.0, 8.0, 8.0, 9.0, 8.0, 8.0, 6.0, 6.0, 8.0, 3.0, 7.0, 7.0, 7.0, 6.0, 6.0, 6.0, 4.0, 9.0, 8.0, 8.0, 8.0, 5.0, 6.0, 5.0, 6.0, 6.0, 6.0, 8.0, 6.0, 5.0, 4.0, 9.0, 6.0, 10.0, 6.0, 7.0, 8.0, 9.0, 5.0, 11.0, 9.0, 8.0, 3.0, 7.0, 10.0, 7.0] Lymph-BNHL SBS85 C>G 27.0 31.0 27.7 28.63 0.851509699864063 1.0 0.459 12633.0 Leading 1.148 1.034 1.111 1 27.0 27.7 16.0 39.0 [21.0, 29.0, 28.0, 26.0, 26.0, 28.0, 31.0, 25.0, 27.0, 27.0, 38.0, 39.0, 26.0, 27.0, 28.0, 26.0, 26.0, 31.0, 32.0, 30.0, 29.0, 24.0, 26.0, 23.0, 25.0, 33.0, 31.0, 31.0, 31.0, 30.0, 27.0, 26.0, 31.0, 29.0, 16.0, 33.0, 27.0, 25.0, 28.0, 30.0, 22.0, 33.0, 29.0, 23.0, 21.0, 30.0, 29.0, 18.0, 20.0, 30.0, 25.0, 18.0, 27.0, 32.0, 30.0, 28.0, 32.0, 30.0, 24.0, 23.0, 30.0, 21.0, 33.0, 27.0, 23.0, 24.0, 37.0, 24.0, 30.0, 29.0, 27.0, 28.0, 28.0, 27.0, 25.0, 28.0, 33.0, 30.0, 30.0, 20.0, 23.0, 30.0, 30.0, 28.0, 20.0, 24.0, 23.0, 26.0, 29.0, 33.0, 35.0, 31.0, 27.0, 32.0, 36.0, 29.0, 22.0, 29.0, 32.0, 27.0] 31.0 28.63 18.0 42.0 [32.0, 30.0, 26.0, 29.0, 31.0, 28.0, 25.0, 28.0, 28.0, 32.0, 20.0, 18.0, 28.0, 32.0, 29.0, 32.0, 28.0, 24.0, 26.0, 28.0, 30.0, 35.0, 28.0, 34.0, 31.0, 26.0, 23.0, 26.0, 26.0, 27.0, 30.0, 31.0, 28.0, 28.0, 37.0, 21.0, 29.0, 30.0, 25.0, 31.0, 33.0, 25.0, 28.0, 35.0, 37.0, 27.0, 25.0, 42.0, 32.0, 29.0, 33.0, 38.0, 31.0, 23.0, 28.0, 26.0, 28.0, 28.0, 33.0, 33.0, 28.0, 35.0, 24.0, 28.0, 29.0, 35.0, 23.0, 35.0, 26.0, 26.0, 28.0, 28.0, 24.0, 30.0, 32.0, 29.0, 24.0, 28.0, 25.0, 37.0, 33.0, 27.0, 25.0, 29.0, 26.0, 30.0, 35.0, 27.0, 26.0, 22.0, 22.0, 26.0, 26.0, 21.0, 20.0, 29.0, 34.0, 30.0, 27.0, 30.0] Lymph-BNHL SBS85 C>T 336.0 320.0 334.6 321.81 0.9559593571088009 1.0 5.193 12633.0 Lagging 1.05 1.04 1.01 336.0 334.6 307.0 365.0 [342.0, 315.0, 344.0, 320.0, 333.0, 317.0, 352.0, 326.0, 360.0, 331.0, 341.0, 339.0, 326.0, 328.0, 331.0, 318.0, 336.0, 309.0, 334.0, 345.0, 323.0, 332.0, 337.0, 328.0, 333.0, 340.0, 314.0, 334.0, 336.0, 326.0, 322.0, 335.0, 307.0, 331.0, 314.0, 351.0, 335.0, 337.0, 327.0, 355.0, 331.0, 350.0, 337.0, 338.0, 338.0, 347.0, 323.0, 335.0, 338.0, 344.0, 365.0, 334.0, 334.0, 319.0, 338.0, 341.0, 319.0, 327.0, 337.0, 340.0, 332.0, 331.0, 327.0, 339.0, 352.0, 334.0, 340.0, 365.0, 335.0, 320.0, 355.0, 331.0, 311.0, 335.0, 347.0, 328.0, 325.0, 327.0, 337.0, 349.0, 352.0, 322.0, 345.0, 329.0, 338.0, 346.0, 342.0, 342.0, 333.0, 337.0, 339.0, 336.0, 336.0, 323.0, 330.0, 332.0, 332.0, 341.0, 352.0, 334.0] 320.0 321.81 295.0 353.0 [307.0, 330.0, 308.0, 325.0, 316.0, 345.0, 299.0, 327.0, 301.0, 321.0, 329.0, 317.0, 334.0, 325.0, 333.0, 341.0, 318.0, 341.0, 324.0, 308.0, 331.0, 325.0, 316.0, 325.0, 327.0, 316.0, 339.0, 326.0, 317.0, 333.0, 331.0, 328.0, 353.0, 318.0, 325.0, 318.0, 316.0, 316.0, 335.0, 314.0, 320.0, 310.0, 315.0, 317.0, 308.0, 318.0, 337.0, 330.0, 324.0, 318.0, 307.0, 321.0, 320.0, 338.0, 312.0, 320.0, 325.0, 324.0, 324.0, 318.0, 331.0, 321.0, 336.0, 321.0, 295.0, 320.0, 329.0, 306.0, 325.0, 316.0, 298.0, 324.0, 352.0, 326.0, 313.0, 335.0, 331.0, 318.0, 315.0, 306.0, 305.0, 341.0, 320.0, 327.0, 306.0, 305.0, 319.0, 310.0, 323.0, 317.0, 320.0, 328.0, 321.0, 343.0, 319.0, 330.0, 328.0, 311.0, 311.0, 315.0] Lymph-BNHL SBS85 T>A 4451.0 4323.0 4451.54 4377.2 0.6839916337937821 1.0 69.453 12633.0 Lagging 1.03 1.017 1.012 4451.0 4451.54 4336.0 4564.0 [4485.0, 4462.0, 4451.0, 4531.0, 4508.0, 4395.0, 4408.0, 4547.0, 4476.0, 4545.0, 4511.0, 4511.0, 4435.0, 4427.0, 4490.0, 4417.0, 4456.0, 4522.0, 4418.0, 4564.0, 4397.0, 4476.0, 4465.0, 4487.0, 4445.0, 4487.0, 4483.0, 4455.0, 4453.0, 4471.0, 4467.0, 4492.0, 4535.0, 4408.0, 4466.0, 4514.0, 4484.0, 4527.0, 4401.0, 4488.0, 4445.0, 4445.0, 4515.0, 4369.0, 4374.0, 4515.0, 4439.0, 4406.0, 4368.0, 4420.0, 4436.0, 4376.0, 4486.0, 4464.0, 4501.0, 4454.0, 4467.0, 4433.0, 4459.0, 4427.0, 4466.0, 4449.0, 4398.0, 4444.0, 4478.0, 4406.0, 4434.0, 4476.0, 4371.0, 4408.0, 4449.0, 4475.0, 4365.0, 4475.0, 4517.0, 4336.0, 4471.0, 4471.0, 4458.0, 4363.0, 4376.0, 4445.0, 4389.0, 4390.0, 4397.0, 4398.0, 4462.0, 4482.0, 4384.0, 4433.0, 4434.0, 4549.0, 4518.0, 4469.0, 4447.0, 4462.0, 4410.0, 4432.0, 4426.0, 4382.0] 4323.0 4377.2 4252.0 4482.0 [4338.0, 4365.0, 4344.0, 4327.0, 4331.0, 4433.0, 4411.0, 4277.0, 4307.0, 4284.0, 4252.0, 4290.0, 4392.0, 4432.0, 4375.0, 4318.0, 4400.0, 4314.0, 4422.0, 4252.0, 4417.0, 4381.0, 4347.0, 4387.0, 4363.0, 4313.0, 4369.0, 4381.0, 4395.0, 4329.0, 4382.0, 4401.0, 4322.0, 4379.0, 4359.0, 4347.0, 4326.0, 4350.0, 4442.0, 4340.0, 4381.0, 4403.0, 4338.0, 4463.0, 4472.0, 4342.0, 4402.0, 4451.0, 4439.0, 4393.0, 4390.0, 4424.0, 4330.0, 4318.0, 4325.0, 4433.0, 4384.0, 4399.0, 4396.0, 4415.0, 4302.0, 4344.0, 4435.0, 4367.0, 4324.0, 4398.0, 4412.0, 4357.0, 4468.0, 4403.0, 4382.0, 4364.0, 4448.0, 4383.0, 4297.0, 4448.0, 4376.0, 4378.0, 4386.0, 4482.0, 4444.0, 4407.0, 4404.0, 4429.0, 4390.0, 4422.0, 4363.0, 4355.0, 4421.0, 4401.0, 4422.0, 4281.0, 4334.0, 4351.0, 4368.0, 4407.0, 4421.0, 4405.0, 4395.0, 4454.0] Lymph-BNHL SBS85 T>C 1457.0 1354.0 1434.66 1351.29 0.8097587850173296 1.0 22.251 12633.0 Lagging 1.076 1.062 1.014 1457.0 1434.66 1364.0 1502.0 [1409.0, 1432.0, 1471.0, 1425.0, 1427.0, 1454.0, 1418.0, 1421.0, 1454.0, 1448.0, 1440.0, 1438.0, 1502.0, 1453.0, 1440.0, 1407.0, 1424.0, 1445.0, 1463.0, 1387.0, 1442.0, 1441.0, 1420.0, 1439.0, 1374.0, 1421.0, 1495.0, 1438.0, 1448.0, 1416.0, 1452.0, 1466.0, 1430.0, 1389.0, 1480.0, 1417.0, 1427.0, 1449.0, 1404.0, 1409.0, 1380.0, 1445.0, 1451.0, 1479.0, 1451.0, 1364.0, 1390.0, 1409.0, 1474.0, 1429.0, 1395.0, 1475.0, 1419.0, 1405.0, 1444.0, 1428.0, 1466.0, 1465.0, 1414.0, 1477.0, 1455.0, 1411.0, 1407.0, 1451.0, 1449.0, 1433.0, 1475.0, 1429.0, 1419.0, 1402.0, 1435.0, 1425.0, 1410.0, 1462.0, 1457.0, 1381.0, 1445.0, 1452.0, 1400.0, 1440.0, 1457.0, 1411.0, 1383.0, 1439.0, 1406.0, 1489.0, 1439.0, 1467.0, 1456.0, 1449.0, 1457.0, 1462.0, 1414.0, 1440.0, 1460.0, 1402.0, 1440.0, 1423.0, 1442.0, 1417.0] 1354.0 1351.29 1281.0 1418.0 [1360.0, 1355.0, 1334.0, 1343.0, 1363.0, 1322.0, 1340.0, 1357.0, 1341.0, 1350.0, 1330.0, 1347.0, 1281.0, 1346.0, 1371.0, 1360.0, 1349.0, 1347.0, 1317.0, 1377.0, 1364.0, 1349.0, 1375.0, 1357.0, 1408.0, 1353.0, 1326.0, 1368.0, 1350.0, 1386.0, 1324.0, 1306.0, 1320.0, 1373.0, 1300.0, 1368.0, 1345.0, 1352.0, 1386.0, 1350.0, 1417.0, 1342.0, 1312.0, 1313.0, 1316.0, 1418.0, 1376.0, 1404.0, 1315.0, 1374.0, 1389.0, 1332.0, 1351.0, 1380.0, 1359.0, 1351.0, 1342.0, 1327.0, 1372.0, 1332.0, 1334.0, 1340.0, 1387.0, 1343.0, 1327.0, 1363.0, 1314.0, 1337.0, 1373.0, 1356.0, 1348.0, 1377.0, 1369.0, 1347.0, 1330.0, 1384.0, 1347.0, 1328.0, 1395.0, 1351.0, 1320.0, 1375.0, 1397.0, 1360.0, 1366.0, 1302.0, 1354.0, 1333.0, 1352.0, 1323.0, 1316.0, 1324.0, 1385.0, 1370.0, 1339.0, 1388.0, 1343.0, 1376.0, 1338.0, 1346.0] Lymph-BNHL SBS85 T>G 183.0 138.0 162.92 163.63 0.07022819801689249 0.2112453728477248 2.541 12633.0 Lagging 1.326 0.996 1.332 1 1 1 183.0 162.92 139.0 189.0 [167.0, 171.0, 159.0, 178.0, 161.0, 165.0, 154.0, 163.0, 162.0, 168.0, 161.0, 150.0, 173.0, 155.0, 160.0, 154.0, 162.0, 162.0, 165.0, 176.0, 140.0, 166.0, 177.0, 169.0, 162.0, 156.0, 169.0, 139.0, 170.0, 159.0, 158.0, 173.0, 161.0, 189.0, 152.0, 145.0, 149.0, 155.0, 160.0, 170.0, 166.0, 171.0, 165.0, 154.0, 161.0, 160.0, 155.0, 170.0, 161.0, 183.0, 164.0, 159.0, 154.0, 185.0, 164.0, 170.0, 156.0, 160.0, 173.0, 152.0, 157.0, 157.0, 164.0, 176.0, 172.0, 170.0, 159.0, 172.0, 159.0, 170.0, 170.0, 159.0, 159.0, 163.0, 165.0, 158.0, 169.0, 172.0, 155.0, 161.0, 162.0, 165.0, 163.0, 173.0, 162.0, 181.0, 170.0, 153.0, 157.0, 156.0, 153.0, 151.0, 161.0, 170.0, 174.0, 165.0, 158.0, 174.0, 150.0, 139.0] 138.0 163.63 132.0 196.0 [159.0, 160.0, 169.0, 154.0, 165.0, 162.0, 169.0, 172.0, 161.0, 159.0, 172.0, 169.0, 154.0, 170.0, 172.0, 173.0, 161.0, 162.0, 165.0, 154.0, 189.0, 154.0, 154.0, 158.0, 160.0, 167.0, 159.0, 181.0, 156.0, 165.0, 162.0, 155.0, 165.0, 132.0, 167.0, 179.0, 173.0, 166.0, 166.0, 160.0, 159.0, 153.0, 163.0, 172.0, 164.0, 167.0, 175.0, 163.0, 167.0, 138.0, 152.0, 164.0, 176.0, 152.0, 168.0, 152.0, 171.0, 166.0, 160.0, 181.0, 163.0, 166.0, 162.0, 156.0, 149.0, 163.0, 173.0, 151.0, 171.0, 155.0, 155.0, 171.0, 166.0, 160.0, 156.0, 173.0, 162.0, 161.0, 176.0, 164.0, 164.0, 159.0, 164.0, 159.0, 165.0, 153.0, 163.0, 176.0, 167.0, 165.0, 172.0, 173.0, 165.0, 154.0, 147.0, 160.0, 165.0, 158.0, 172.0, 196.0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change