# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types.
MutationType	Across_All_Cancer_Types
T:A[C>A]A	5.5
U:A[C>A]A	6.0
B:A[C>A]A	0.0
N:A[C>A]A	53.0
T:A[C>A]C	0.0
U:A[C>A]C	0.0
B:A[C>A]C	0.0
N:A[C>A]C	1.0
T:A[C>A]G	0.0
U:A[C>A]G	0.0
B:A[C>A]G	0.0
N:A[C>A]G	0.0
T:A[C>A]T	1.0
U:A[C>A]T	0.5
B:A[C>A]T	0.0
N:A[C>A]T	14.5
T:A[C>G]A	3.0
U:A[C>G]A	0.5
B:A[C>G]A	0.0
N:A[C>G]A	20.0
T:A[C>G]C	0.0
U:A[C>G]C	0.0
B:A[C>G]C	0.0
N:A[C>G]C	5.5
T:A[C>G]G	0.0
U:A[C>G]G	0.0
B:A[C>G]G	0.0
N:A[C>G]G	0.0
T:A[C>G]T	11.5
U:A[C>G]T	16.0
B:A[C>G]T	0.0
N:A[C>G]T	75.5
T:A[C>T]A	0.0
U:A[C>T]A	0.0
B:A[C>T]A	0.0
N:A[C>T]A	0.0
T:A[C>T]C	0.0
U:A[C>T]C	0.0
B:A[C>T]C	0.0
N:A[C>T]C	0.5
T:A[C>T]G	0.0
U:A[C>T]G	0.0
B:A[C>T]G	0.0
N:A[C>T]G	0.0
T:A[C>T]T	1.5
U:A[C>T]T	1.5
B:A[C>T]T	0.0
N:A[C>T]T	15.5
T:A[T>A]A	225.5
U:A[T>A]A	248.0
B:A[T>A]A	1.0
N:A[T>A]A	794.0
T:A[T>A]C	13.0
U:A[T>A]C	7.5
B:A[T>A]C	0.0
N:A[T>A]C	66.0
T:A[T>A]G	33.0
U:A[T>A]G	39.0
B:A[T>A]G	1.0
N:A[T>A]G	179.0
T:A[T>A]T	94.5
U:A[T>A]T	108.0
B:A[T>A]T	0.5
N:A[T>A]T	400.0
T:A[T>C]A	49.0
U:A[T>C]A	51.5
B:A[T>C]A	0.0
N:A[T>C]A	189.5
T:A[T>C]C	14.0
U:A[T>C]C	13.0
B:A[T>C]C	0.0
N:A[T>C]C	70.0
T:A[T>C]G	4.5
U:A[T>C]G	2.0
B:A[T>C]G	0.0
N:A[T>C]G	19.0
T:A[T>C]T	89.5
U:A[T>C]T	118.5
B:A[T>C]T	2.5
N:A[T>C]T	363.0
T:A[T>G]A	73.0
U:A[T>G]A	72.5
B:A[T>G]A	0.5
N:A[T>G]A	305.0
T:A[T>G]C	3.0
U:A[T>G]C	5.0
B:A[T>G]C	0.0
N:A[T>G]C	19.5
T:A[T>G]G	1.0
U:A[T>G]G	1.0
B:A[T>G]G	0.0
N:A[T>G]G	21.0
T:A[T>G]T	4.0
U:A[T>G]T	7.5
B:A[T>G]T	0.0
N:A[T>G]T	27.0
T:C[C>A]A	4.5
U:C[C>A]A	3.0
B:C[C>A]A	0.0
N:C[C>A]A	33.0
T:C[C>A]C	0.0
U:C[C>A]C	0.0
B:C[C>A]C	0.0
N:C[C>A]C	0.0
T:C[C>A]G	0.0
U:C[C>A]G	0.0
B:C[C>A]G	0.0
N:C[C>A]G	0.0
T:C[C>A]T	0.0
U:C[C>A]T	0.0
B:C[C>A]T	0.0
N:C[C>A]T	1.0
T:C[C>G]A	1.0
U:C[C>G]A	2.0
B:C[C>G]A	0.0
N:C[C>G]A	10.5
T:C[C>G]C	0.0
U:C[C>G]C	0.0
B:C[C>G]C	0.0
N:C[C>G]C	0.0
T:C[C>G]G	0.0
U:C[C>G]G	0.0
B:C[C>G]G	0.0
N:C[C>G]G	0.0
T:C[C>G]T	0.0
U:C[C>G]T	0.0
B:C[C>G]T	0.0
N:C[C>G]T	0.0
T:C[C>T]A	0.0
U:C[C>T]A	0.0
B:C[C>T]A	0.0
N:C[C>T]A	0.5
T:C[C>T]C	0.0
U:C[C>T]C	0.0
B:C[C>T]C	0.0
N:C[C>T]C	0.0
T:C[C>T]G	0.0
U:C[C>T]G	0.0
B:C[C>T]G	0.0
N:C[C>T]G	0.0
T:C[C>T]T	0.0
U:C[C>T]T	0.0
B:C[C>T]T	0.0
N:C[C>T]T	0.5
T:C[T>A]A	37.0
U:C[T>A]A	37.5
B:C[T>A]A	0.0
N:C[T>A]A	152.0
T:C[T>A]C	2.5
U:C[T>A]C	1.5
B:C[T>A]C	0.0
N:C[T>A]C	9.0
T:C[T>A]G	0.0
U:C[T>A]G	0.0
B:C[T>A]G	0.0
N:C[T>A]G	1.0
T:C[T>A]T	15.0
U:C[T>A]T	24.5
B:C[T>A]T	0.0
N:C[T>A]T	90.5
T:C[T>C]A	8.0
U:C[T>C]A	6.0
B:C[T>C]A	0.0
N:C[T>C]A	46.5
T:C[T>C]C	4.0
U:C[T>C]C	3.0
B:C[T>C]C	0.0
N:C[T>C]C	28.0
T:C[T>C]G	0.0
U:C[T>C]G	0.0
B:C[T>C]G	0.0
N:C[T>C]G	0.0
T:C[T>C]T	30.5
U:C[T>C]T	32.5
B:C[T>C]T	0.0
N:C[T>C]T	144.5
T:C[T>G]A	11.0
U:C[T>G]A	10.0
B:C[T>G]A	0.0
N:C[T>G]A	46.0
T:C[T>G]C	3.0
U:C[T>G]C	2.5
B:C[T>G]C	0.0
N:C[T>G]C	15.5
T:C[T>G]G	0.0
U:C[T>G]G	1.0
B:C[T>G]G	0.0
N:C[T>G]G	4.5
T:C[T>G]T	4.5
U:C[T>G]T	6.5
B:C[T>G]T	0.0
N:C[T>G]T	39.0
T:G[C>A]A	0.0
U:G[C>A]A	1.0
B:G[C>A]A	0.0
N:G[C>A]A	6.5
T:G[C>A]C	0.0
U:G[C>A]C	0.0
B:G[C>A]C	0.0
N:G[C>A]C	0.0
T:G[C>A]G	0.0
U:G[C>A]G	0.0
B:G[C>A]G	0.0
N:G[C>A]G	0.0
T:G[C>A]T	0.0
U:G[C>A]T	0.0
B:G[C>A]T	0.0
N:G[C>A]T	0.0
T:G[C>G]A	0.0
U:G[C>G]A	0.5
B:G[C>G]A	0.0
N:G[C>G]A	4.5
T:G[C>G]C	5.0
U:G[C>G]C	6.5
B:G[C>G]C	0.0
N:G[C>G]C	32.0
T:G[C>G]G	0.0
U:G[C>G]G	0.0
B:G[C>G]G	0.0
N:G[C>G]G	0.0
T:G[C>G]T	1.5
U:G[C>G]T	2.5
B:G[C>G]T	0.0
N:G[C>G]T	39.5
T:G[C>T]A	0.0
U:G[C>T]A	0.0
B:G[C>T]A	0.0
N:G[C>T]A	0.0
T:G[C>T]C	0.0
U:G[C>T]C	0.0
B:G[C>T]C	0.0
N:G[C>T]C	0.0
T:G[C>T]G	0.0
U:G[C>T]G	0.0
B:G[C>T]G	0.0
N:G[C>T]G	0.0
T:G[C>T]T	4.0
U:G[C>T]T	2.5
B:G[C>T]T	0.0
N:G[C>T]T	39.5
T:G[T>A]A	47.5
U:G[T>A]A	72.0
B:G[T>A]A	0.0
N:G[T>A]A	182.5
T:G[T>A]C	1.5
U:G[T>A]C	1.0
B:G[T>A]C	0.0
N:G[T>A]C	7.5
T:G[T>A]G	9.0
U:G[T>A]G	13.5
B:G[T>A]G	0.0
N:G[T>A]G	48.0
T:G[T>A]T	17.5
U:G[T>A]T	28.5
B:G[T>A]T	0.5
N:G[T>A]T	98.5
T:G[T>C]A	24.5
U:G[T>C]A	35.0
B:G[T>C]A	0.0
N:G[T>C]A	106.0
T:G[T>C]C	8.0
U:G[T>C]C	8.0
B:G[T>C]C	0.0
N:G[T>C]C	54.5
T:G[T>C]G	4.0
U:G[T>C]G	6.5
B:G[T>C]G	0.5
N:G[T>C]G	29.5
T:G[T>C]T	50.5
U:G[T>C]T	79.5
B:G[T>C]T	0.0
N:G[T>C]T	221.5
T:G[T>G]A	18.0
U:G[T>G]A	25.5
B:G[T>G]A	0.5
N:G[T>G]A	79.5
T:G[T>G]C	0.0
U:G[T>G]C	0.5
B:G[T>G]C	0.0
N:G[T>G]C	1.5
T:G[T>G]G	0.0
U:G[T>G]G	0.0
B:G[T>G]G	0.0
N:G[T>G]G	3.0
T:G[T>G]T	3.0
U:G[T>G]T	9.0
B:G[T>G]T	0.0
N:G[T>G]T	26.5
T:T[C>A]A	1.5
U:T[C>A]A	2.5
B:T[C>A]A	0.0
N:T[C>A]A	22.0
T:T[C>A]C	0.0
U:T[C>A]C	0.0
B:T[C>A]C	0.0
N:T[C>A]C	0.5
T:T[C>A]G	0.0
U:T[C>A]G	0.0
B:T[C>A]G	0.0
N:T[C>A]G	0.0
T:T[C>A]T	2.0
U:T[C>A]T	5.0
B:T[C>A]T	0.0
N:T[C>A]T	24.5
T:T[C>G]A	1.0
U:T[C>G]A	0.0
B:T[C>G]A	0.0
N:T[C>G]A	8.0
T:T[C>G]C	5.0
U:T[C>G]C	5.5
B:T[C>G]C	0.0
N:T[C>G]C	18.5
T:T[C>G]G	0.0
U:T[C>G]G	0.0
B:T[C>G]G	0.0
N:T[C>G]G	0.0
T:T[C>G]T	11.0
U:T[C>G]T	14.5
B:T[C>G]T	0.0
N:T[C>G]T	75.5
T:T[C>T]A	7.0
U:T[C>T]A	6.5
B:T[C>T]A	0.0
N:T[C>T]A	37.5
T:T[C>T]C	0.5
U:T[C>T]C	0.0
B:T[C>T]C	0.0
N:T[C>T]C	4.0
T:T[C>T]G	0.0
U:T[C>T]G	0.0
B:T[C>T]G	0.0
N:T[C>T]G	0.0
T:T[C>T]T	58.5
U:T[C>T]T	63.0
B:T[C>T]T	0.5
N:T[C>T]T	252.0
T:T[T>A]A	106.0
U:T[T>A]A	122.5
B:T[T>A]A	1.0
N:T[T>A]A	446.0
T:T[T>A]C	6.5
U:T[T>A]C	9.5
B:T[T>A]C	0.0
N:T[T>A]C	46.5
T:T[T>A]G	11.0
U:T[T>A]G	26.0
B:T[T>A]G	0.0
N:T[T>A]G	79.0
T:T[T>A]T	67.5
U:T[T>A]T	117.5
B:T[T>A]T	0.5
N:T[T>A]T	345.0
T:T[T>C]A	32.5
U:T[T>C]A	42.0
B:T[T>C]A	0.0
N:T[T>C]A	138.0
T:T[T>C]C	24.5
U:T[T>C]C	29.5
B:T[T>C]C	0.0
N:T[T>C]C	106.5
T:T[T>C]G	1.0
U:T[T>C]G	4.0
B:T[T>C]G	0.0
N:T[T>C]G	19.5
T:T[T>C]T	142.5
U:T[T>C]T	220.5
B:T[T>C]T	1.0
N:T[T>C]T	574.0
T:T[T>G]A	21.0
U:T[T>G]A	23.5
B:T[T>G]A	0.0
N:T[T>G]A	112.5
T:T[T>G]C	4.5
U:T[T>G]C	8.5
B:T[T>G]C	0.0
N:T[T>G]C	33.0
T:T[T>G]G	1.5
U:T[T>G]G	2.5
B:T[T>G]G	0.0
N:T[T>G]G	12.0
T:T[T>G]T	22.5
U:T[T>G]T	36.0
B:T[T>G]T	0.0
N:T[T>G]T	151.0

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	genic_real_count	intergenic_real_count	genic_mean_sims_count	intergenic_mean_sims_count	genic_versus_intergenic_p_value	genic_versus_intergenic_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Transcribed_real_count	Transcribed_mean_sims_count	Transcribed_min_sims_count	Transcribed_max_sims_count	Transcribed_sims_count_list	UnTranscribed_real_count	UnTranscribed_mean_sims_count	UnTranscribed_min_sims_count	UnTranscribed_max_sims_count	UnTranscribed_sims_count_list	NonTranscribed_real_count	NonTranscribed_mean_sims_count	NonTranscribed_min_sims_count	NonTranscribed_max_sims_count	NonTranscribed_sims_count_list
Lymph-BNHL	SBS85	C>A	6.0	8.0	6.0	8.12	1.0	1.0	0.101	13844.0	Intergenic	1.333	1.353	0.985							1.0	3.26	0.0	7.0	[2.0, 5.0, 3.0, 4.0, 3.0, 4.0, 5.0, 4.0, 2.0, 6.0, 3.0, 2.0, 2.0, 4.0, 2.0, 6.0, 2.0, 4.0, 2.0, 1.0, 4.0, 2.0, 4.0, 4.0, 3.0, 3.0, 5.0, 4.0, 3.0, 4.0, 3.0, 1.0, 1.0, 3.0, 4.0, 2.0, 4.0, 2.0, 3.0, 3.0, 2.0, 3.0, 3.0, 3.0, 2.0, 1.0, 3.0, 3.0, 2.0, 4.0, 2.0, 4.0, 4.0, 2.0, 4.0, 4.0, 4.0, 4.0, 1.0, 6.0, 1.0, 2.0, 4.0, 4.0, 1.0, 3.0, 3.0, 6.0, 5.0, 3.0, 4.0, 3.0, 4.0, 5.0, 3.0, 3.0, 3.0, 4.0, 3.0, 2.0, 4.0, 5.0, 5.0, 4.0, 7.0, 5.0, 1.0, 2.0, 4.0, 5.0, 2.0, 4.0, 2.0, 3.0, 4.0, 5.0, 2.0, 4.0, 3.0, 0.0]	5.0	2.74	0.0	8.0	[4.0, 1.0, 2.0, 3.0, 3.0, 3.0, 4.0, 4.0, 3.0, 0.0, 1.0, 4.0, 3.0, 3.0, 2.0, 4.0, 4.0, 4.0, 3.0, 3.0, 3.0, 5.0, 1.0, 4.0, 3.0, 3.0, 1.0, 1.0, 4.0, 5.0, 2.0, 4.0, 3.0, 6.0, 5.0, 1.0, 4.0, 1.0, 2.0, 1.0, 4.0, 3.0, 4.0, 5.0, 2.0, 4.0, 4.0, 2.0, 3.0, 2.0, 4.0, 3.0, 4.0, 2.0, 3.0, 1.0, 3.0, 2.0, 1.0, 1.0, 2.0, 3.0, 3.0, 1.0, 5.0, 1.0, 0.0, 2.0, 3.0, 2.0, 2.0, 2.0, 3.0, 2.0, 1.0, 4.0, 1.0, 1.0, 4.0, 3.0, 1.0, 4.0, 1.0, 5.0, 2.0, 1.0, 3.0, 1.0, 2.0, 1.0, 1.0, 3.0, 8.0, 5.0, 6.0, 2.0, 2.0, 2.0, 3.0, 2.0]	8.0	8.12	4.0	12.0	[8.0, 8.0, 9.0, 8.0, 8.0, 7.0, 5.0, 6.0, 9.0, 8.0, 10.0, 8.0, 9.0, 8.0, 10.0, 5.0, 8.0, 6.0, 9.0, 10.0, 7.0, 7.0, 9.0, 7.0, 8.0, 9.0, 8.0, 9.0, 8.0, 5.0, 9.0, 9.0, 10.0, 5.0, 5.0, 11.0, 7.0, 11.0, 9.0, 10.0, 8.0, 8.0, 7.0, 6.0, 10.0, 9.0, 7.0, 9.0, 9.0, 8.0, 8.0, 7.0, 6.0, 10.0, 7.0, 9.0, 7.0, 8.0, 12.0, 7.0, 11.0, 9.0, 7.0, 9.0, 9.0, 10.0, 11.0, 6.0, 6.0, 9.0, 8.0, 9.0, 7.0, 7.0, 10.0, 7.0, 10.0, 9.0, 7.0, 9.0, 9.0, 5.0, 8.0, 5.0, 6.0, 9.0, 10.0, 11.0, 9.0, 8.0, 11.0, 7.0, 4.0, 6.0, 5.0, 7.0, 10.0, 8.0, 8.0, 12.0]
Lymph-BNHL	SBS85	C>G	19.0	42.0	28.5	33.03	0.13629020269991438	0.36785659916688135	0.441	13844.0	Intergenic	2.211	1.159	1.907	1	1	1	1	1		12.0	14.62	6.0	23.0	[11.0, 14.0, 18.0, 13.0, 14.0, 11.0, 13.0, 15.0, 14.0, 15.0, 10.0, 16.0, 7.0, 13.0, 17.0, 18.0, 16.0, 12.0, 13.0, 10.0, 14.0, 15.0, 19.0, 20.0, 17.0, 12.0, 20.0, 13.0, 12.0, 16.0, 16.0, 14.0, 16.0, 15.0, 9.0, 18.0, 19.0, 14.0, 16.0, 18.0, 15.0, 16.0, 16.0, 17.0, 14.0, 10.0, 16.0, 13.0, 12.0, 9.0, 12.0, 15.0, 17.0, 17.0, 18.0, 16.0, 9.0, 18.0, 23.0, 14.0, 12.0, 19.0, 16.0, 20.0, 6.0, 12.0, 13.0, 18.0, 8.0, 13.0, 16.0, 18.0, 14.0, 12.0, 9.0, 18.0, 17.0, 12.0, 16.0, 16.0, 18.0, 15.0, 13.0, 18.0, 14.0, 18.0, 12.0, 14.0, 10.0, 11.0, 17.0, 20.0, 17.0, 12.0, 11.0, 13.0, 19.0, 18.0, 15.0, 12.0]	7.0	13.88	8.0	22.0	[18.0, 10.0, 11.0, 15.0, 17.0, 14.0, 16.0, 19.0, 14.0, 18.0, 21.0, 10.0, 16.0, 11.0, 17.0, 12.0, 15.0, 11.0, 16.0, 15.0, 14.0, 8.0, 18.0, 11.0, 12.0, 18.0, 15.0, 15.0, 13.0, 8.0, 12.0, 11.0, 12.0, 17.0, 12.0, 10.0, 8.0, 13.0, 11.0, 10.0, 13.0, 11.0, 15.0, 12.0, 8.0, 15.0, 15.0, 11.0, 13.0, 21.0, 9.0, 15.0, 14.0, 12.0, 13.0, 14.0, 18.0, 13.0, 9.0, 22.0, 15.0, 12.0, 16.0, 17.0, 17.0, 17.0, 14.0, 10.0, 17.0, 17.0, 13.0, 17.0, 14.0, 15.0, 14.0, 12.0, 9.0, 12.0, 15.0, 12.0, 13.0, 19.0, 15.0, 12.0, 12.0, 12.0, 16.0, 14.0, 12.0, 12.0, 15.0, 11.0, 16.0, 14.0, 16.0, 12.0, 13.0, 18.0, 12.0, 22.0]	42.0	33.03	24.0	40.0	[32.0, 38.0, 32.0, 33.0, 30.0, 36.0, 33.0, 27.0, 35.0, 29.0, 30.0, 36.0, 38.0, 37.0, 29.0, 31.0, 30.0, 38.0, 32.0, 36.0, 33.0, 38.0, 24.0, 31.0, 33.0, 31.0, 27.0, 33.0, 38.0, 38.0, 33.0, 36.0, 34.0, 29.0, 40.0, 33.0, 34.0, 34.0, 35.0, 36.0, 34.0, 35.0, 31.0, 32.0, 39.0, 37.0, 30.0, 37.0, 36.0, 33.0, 40.0, 31.0, 31.0, 32.0, 30.0, 31.0, 35.0, 30.0, 30.0, 27.0, 35.0, 31.0, 31.0, 24.0, 38.0, 32.0, 34.0, 35.0, 37.0, 31.0, 32.0, 26.0, 33.0, 34.0, 39.0, 32.0, 35.0, 37.0, 32.0, 34.0, 31.0, 27.0, 34.0, 31.0, 36.0, 32.0, 33.0, 35.0, 39.0, 38.0, 30.0, 30.0, 29.0, 35.0, 35.0, 36.0, 29.0, 25.0, 34.0, 29.0]
Lymph-BNHL	SBS85	C>T	256.0	458.0	299.66	415.37	0.022559886918230663	0.076377855621008	5.157	13844.0	Intergenic	1.789	1.386	1.291	1	1					129.0	143.97	120.0	165.0	[158.0, 142.0, 158.0, 144.0, 150.0, 147.0, 144.0, 124.0, 143.0, 152.0, 143.0, 157.0, 143.0, 164.0, 138.0, 146.0, 135.0, 139.0, 162.0, 154.0, 139.0, 132.0, 133.0, 136.0, 148.0, 131.0, 147.0, 126.0, 147.0, 134.0, 132.0, 154.0, 146.0, 125.0, 125.0, 159.0, 145.0, 123.0, 140.0, 156.0, 161.0, 157.0, 150.0, 140.0, 135.0, 120.0, 130.0, 138.0, 156.0, 154.0, 147.0, 133.0, 165.0, 151.0, 137.0, 134.0, 138.0, 148.0, 144.0, 123.0, 126.0, 132.0, 139.0, 140.0, 132.0, 136.0, 145.0, 134.0, 141.0, 140.0, 142.0, 152.0, 142.0, 150.0, 159.0, 160.0, 149.0, 151.0, 130.0, 142.0, 155.0, 146.0, 147.0, 128.0, 145.0, 153.0, 148.0, 153.0, 148.0, 154.0, 160.0, 158.0, 154.0, 156.0, 136.0, 146.0, 147.0, 145.0, 143.0, 151.0]	127.0	155.69	120.0	181.0	[176.0, 157.0, 158.0, 145.0, 144.0, 160.0, 162.0, 164.0, 158.0, 157.0, 176.0, 147.0, 120.0, 144.0, 143.0, 169.0, 173.0, 157.0, 156.0, 135.0, 149.0, 164.0, 161.0, 163.0, 137.0, 155.0, 162.0, 167.0, 164.0, 161.0, 152.0, 168.0, 156.0, 153.0, 150.0, 158.0, 167.0, 162.0, 123.0, 165.0, 136.0, 165.0, 150.0, 141.0, 159.0, 143.0, 163.0, 169.0, 154.0, 171.0, 152.0, 131.0, 157.0, 162.0, 172.0, 152.0, 142.0, 141.0, 157.0, 172.0, 181.0, 163.0, 180.0, 142.0, 150.0, 156.0, 149.0, 163.0, 163.0, 147.0, 148.0, 153.0, 169.0, 150.0, 157.0, 136.0, 155.0, 167.0, 155.0, 169.0, 175.0, 161.0, 156.0, 155.0, 147.0, 144.0, 162.0, 148.0, 149.0, 145.0, 138.0, 137.0, 147.0, 177.0, 169.0, 152.0, 155.0, 166.0, 155.0, 151.0]	458.0	415.37	381.0	451.0	[381.0, 415.0, 401.0, 427.0, 422.0, 409.0, 408.0, 427.0, 415.0, 406.0, 394.0, 411.0, 450.0, 410.0, 436.0, 402.0, 409.0, 421.0, 397.0, 429.0, 427.0, 419.0, 423.0, 417.0, 430.0, 427.0, 405.0, 421.0, 403.0, 418.0, 430.0, 394.0, 413.0, 435.0, 438.0, 398.0, 403.0, 430.0, 450.0, 395.0, 416.0, 392.0, 415.0, 434.0, 420.0, 451.0, 423.0, 409.0, 404.0, 390.0, 416.0, 448.0, 393.0, 407.0, 404.0, 429.0, 434.0, 425.0, 414.0, 417.0, 407.0, 423.0, 395.0, 433.0, 433.0, 423.0, 421.0, 419.0, 411.0, 428.0, 425.0, 410.0, 406.0, 415.0, 397.0, 423.0, 409.0, 399.0, 428.0, 402.0, 387.0, 408.0, 415.0, 433.0, 423.0, 419.0, 405.0, 412.0, 419.0, 417.0, 415.0, 421.0, 414.0, 384.0, 408.0, 415.0, 413.0, 406.0, 415.0, 414.0]
Lymph-BNHL	SBS85	T>A	3792.0	5865.0	3998.74	5640.67	0.0017757011902992453	0.007116028067933253	69.756	13844.0	Intergenic	1.547	1.411	1.096	1						1711.0	1937.64	1857.0	2020.0	[1941.0, 1930.0, 1940.0, 2020.0, 1930.0, 1928.0, 1916.0, 1867.0, 1896.0, 1918.0, 2018.0, 1928.0, 1946.0, 1956.0, 1957.0, 1898.0, 1979.0, 1910.0, 1898.0, 1952.0, 1895.0, 1907.0, 1887.0, 1959.0, 1911.0, 1944.0, 1956.0, 1975.0, 1877.0, 1923.0, 1900.0, 1972.0, 2011.0, 1921.0, 1895.0, 1969.0, 1928.0, 1915.0, 2003.0, 1938.0, 1954.0, 1929.0, 1994.0, 1943.0, 1872.0, 1956.0, 2001.0, 1972.0, 1979.0, 1918.0, 1894.0, 1929.0, 1955.0, 1983.0, 1920.0, 1934.0, 1894.0, 1903.0, 1919.0, 1972.0, 1949.0, 1857.0, 1932.0, 1959.0, 1955.0, 1970.0, 1923.0, 1960.0, 1969.0, 1994.0, 1967.0, 1962.0, 1920.0, 1976.0, 1929.0, 1937.0, 2012.0, 1959.0, 1905.0, 1948.0, 1901.0, 1939.0, 1956.0, 1952.0, 1937.0, 1864.0, 1979.0, 1878.0, 1874.0, 1870.0, 1920.0, 1900.0, 2003.0, 1940.0, 1899.0, 1988.0, 1952.0, 1907.0, 1958.0, 1929.0]	2081.0	2061.1	1956.0	2173.0	[2068.0, 2071.0, 2102.0, 2060.0, 2081.0, 2057.0, 2148.0, 2097.0, 2027.0, 2121.0, 2015.0, 2055.0, 2013.0, 2045.0, 2111.0, 2082.0, 2073.0, 2076.0, 2074.0, 2051.0, 2046.0, 2075.0, 2111.0, 2053.0, 2049.0, 1956.0, 2043.0, 2083.0, 2148.0, 2058.0, 2058.0, 1999.0, 2053.0, 2142.0, 2001.0, 2070.0, 1991.0, 2062.0, 2069.0, 2061.0, 2023.0, 2083.0, 2030.0, 2005.0, 2036.0, 2052.0, 2058.0, 2068.0, 2045.0, 2045.0, 2039.0, 2105.0, 1982.0, 2071.0, 2022.0, 2092.0, 2009.0, 2071.0, 2012.0, 2046.0, 2109.0, 2076.0, 2082.0, 2006.0, 2086.0, 2057.0, 2173.0, 2025.0, 1991.0, 2083.0, 2107.0, 2135.0, 2115.0, 2025.0, 2103.0, 2048.0, 2051.0, 2071.0, 2105.0, 2058.0, 2082.0, 2093.0, 2052.0, 2103.0, 2015.0, 2066.0, 1997.0, 2072.0, 2004.0, 2069.0, 2021.0, 2061.0, 2093.0, 2059.0, 2067.0, 2003.0, 1990.0, 2134.0, 2052.0, 2122.0]	5865.0	5640.67	5542.0	5754.0	[5634.0, 5623.0, 5604.0, 5573.0, 5627.0, 5646.0, 5577.0, 5674.0, 5713.0, 5601.0, 5612.0, 5655.0, 5688.0, 5635.0, 5565.0, 5651.0, 5589.0, 5653.0, 5667.0, 5642.0, 5702.0, 5650.0, 5628.0, 5628.0, 5685.0, 5736.0, 5639.0, 5588.0, 5607.0, 5656.0, 5680.0, 5681.0, 5577.0, 5573.0, 5754.0, 5603.0, 5702.0, 5663.0, 5571.0, 5630.0, 5668.0, 5627.0, 5620.0, 5692.0, 5731.0, 5638.0, 5578.0, 5606.0, 5610.0, 5674.0, 5703.0, 5608.0, 5698.0, 5596.0, 5687.0, 5620.0, 5739.0, 5664.0, 5714.0, 5622.0, 5591.0, 5715.0, 5621.0, 5679.0, 5613.0, 5618.0, 5544.0, 5658.0, 5680.0, 5578.0, 5569.0, 5542.0, 5598.0, 5645.0, 5607.0, 5650.0, 5588.0, 5613.0, 5623.0, 5626.0, 5657.0, 5611.0, 5631.0, 5578.0, 5682.0, 5700.0, 5655.0, 5686.0, 5752.0, 5702.0, 5700.0, 5668.0, 5551.0, 5638.0, 5675.0, 5647.0, 5694.0, 5589.0, 5621.0, 5595.0]
Lymph-BNHL	SBS85	T>C	1256.0	1786.0	1288.98	1754.91	0.420393996717122	0.839970395491548	21.973	13844.0	Intergenic	1.422	1.361	1.044							538.0	576.18	539.0	618.0	[575.0, 565.0, 557.0, 539.0, 590.0, 600.0, 584.0, 603.0, 568.0, 565.0, 566.0, 542.0, 568.0, 576.0, 557.0, 567.0, 559.0, 566.0, 572.0, 588.0, 567.0, 568.0, 575.0, 584.0, 572.0, 564.0, 552.0, 581.0, 573.0, 583.0, 594.0, 586.0, 553.0, 589.0, 601.0, 558.0, 571.0, 576.0, 587.0, 566.0, 594.0, 601.0, 550.0, 553.0, 589.0, 605.0, 584.0, 573.0, 552.0, 562.0, 585.0, 582.0, 581.0, 558.0, 598.0, 586.0, 581.0, 548.0, 601.0, 584.0, 590.0, 606.0, 563.0, 573.0, 613.0, 557.0, 570.0, 557.0, 552.0, 577.0, 581.0, 561.0, 569.0, 550.0, 562.0, 577.0, 586.0, 544.0, 595.0, 565.0, 603.0, 571.0, 569.0, 594.0, 591.0, 589.0, 584.0, 558.0, 598.0, 561.0, 572.0, 618.0, 608.0, 562.0, 591.0, 603.0, 565.0, 573.0, 572.0, 614.0]	718.0	712.8	647.0	771.0	[726.0, 706.0, 724.0, 734.0, 728.0, 670.0, 686.0, 716.0, 684.0, 697.0, 720.0, 704.0, 728.0, 705.0, 729.0, 693.0, 759.0, 712.0, 702.0, 695.0, 688.0, 736.0, 683.0, 729.0, 688.0, 744.0, 771.0, 732.0, 704.0, 691.0, 700.0, 727.0, 694.0, 687.0, 688.0, 724.0, 704.0, 656.0, 708.0, 765.0, 673.0, 674.0, 724.0, 736.0, 711.0, 647.0, 726.0, 727.0, 703.0, 699.0, 694.0, 713.0, 694.0, 701.0, 703.0, 731.0, 728.0, 734.0, 703.0, 704.0, 709.0, 749.0, 748.0, 739.0, 705.0, 709.0, 745.0, 743.0, 667.0, 734.0, 739.0, 718.0, 729.0, 758.0, 730.0, 723.0, 719.0, 735.0, 721.0, 660.0, 683.0, 700.0, 700.0, 705.0, 701.0, 720.0, 704.0, 705.0, 717.0, 744.0, 719.0, 710.0, 659.0, 692.0, 705.0, 715.0, 762.0, 720.0, 733.0, 744.0]	1786.0	1754.91	1692.0	1823.0	[1742.0, 1771.0, 1769.0, 1771.0, 1725.0, 1773.0, 1774.0, 1722.0, 1792.0, 1773.0, 1759.0, 1802.0, 1745.0, 1772.0, 1758.0, 1780.0, 1722.0, 1764.0, 1768.0, 1763.0, 1789.0, 1736.0, 1782.0, 1732.0, 1785.0, 1738.0, 1722.0, 1726.0, 1770.0, 1769.0, 1757.0, 1737.0, 1795.0, 1762.0, 1758.0, 1763.0, 1771.0, 1805.0, 1752.0, 1718.0, 1781.0, 1766.0, 1772.0, 1756.0, 1747.0, 1794.0, 1732.0, 1745.0, 1785.0, 1779.0, 1765.0, 1750.0, 1770.0, 1779.0, 1743.0, 1731.0, 1735.0, 1758.0, 1737.0, 1756.0, 1741.0, 1692.0, 1734.0, 1732.0, 1721.0, 1779.0, 1723.0, 1755.0, 1823.0, 1736.0, 1730.0, 1765.0, 1750.0, 1739.0, 1748.0, 1741.0, 1744.0, 1762.0, 1725.0, 1811.0, 1761.0, 1776.0, 1774.0, 1739.0, 1755.0, 1736.0, 1751.0, 1773.0, 1731.0, 1737.0, 1754.0, 1721.0, 1776.0, 1789.0, 1754.0, 1722.0, 1712.0, 1751.0, 1743.0, 1692.0]
Lymph-BNHL	SBS85	T>G	133.0	223.0	146.38	210.13	0.3569333662144455	0.7516919416055511	2.572	13844.0	Intergenic	1.677	1.436	1.168	1						60.0	74.1	53.0	95.0	[79.0, 78.0, 73.0, 63.0, 68.0, 86.0, 79.0, 70.0, 82.0, 74.0, 66.0, 68.0, 76.0, 80.0, 77.0, 87.0, 68.0, 92.0, 64.0, 60.0, 67.0, 86.0, 69.0, 67.0, 60.0, 95.0, 67.0, 85.0, 73.0, 65.0, 77.0, 55.0, 76.0, 68.0, 70.0, 88.0, 54.0, 72.0, 78.0, 74.0, 65.0, 72.0, 72.0, 66.0, 85.0, 64.0, 65.0, 69.0, 72.0, 76.0, 68.0, 70.0, 77.0, 86.0, 66.0, 79.0, 66.0, 80.0, 77.0, 72.0, 79.0, 79.0, 70.0, 78.0, 76.0, 61.0, 82.0, 84.0, 65.0, 81.0, 70.0, 69.0, 82.0, 66.0, 81.0, 65.0, 89.0, 72.0, 78.0, 53.0, 95.0, 79.0, 74.0, 77.0, 79.0, 75.0, 76.0, 77.0, 72.0, 90.0, 70.0, 81.0, 65.0, 87.0, 76.0, 77.0, 62.0, 87.0, 73.0, 75.0]	73.0	72.28	53.0	98.0	[71.0, 82.0, 76.0, 70.0, 57.0, 72.0, 74.0, 66.0, 66.0, 62.0, 81.0, 62.0, 72.0, 58.0, 75.0, 54.0, 75.0, 74.0, 89.0, 78.0, 85.0, 65.0, 67.0, 77.0, 74.0, 63.0, 68.0, 68.0, 77.0, 73.0, 76.0, 84.0, 70.0, 67.0, 69.0, 75.0, 70.0, 80.0, 76.0, 77.0, 69.0, 81.0, 98.0, 83.0, 78.0, 79.0, 72.0, 71.0, 72.0, 76.0, 80.0, 72.0, 81.0, 57.0, 62.0, 70.0, 75.0, 76.0, 73.0, 84.0, 80.0, 67.0, 69.0, 73.0, 73.0, 78.0, 65.0, 72.0, 76.0, 75.0, 72.0, 88.0, 60.0, 66.0, 53.0, 83.0, 66.0, 65.0, 72.0, 71.0, 81.0, 57.0, 70.0, 70.0, 68.0, 77.0, 79.0, 77.0, 71.0, 61.0, 67.0, 65.0, 65.0, 72.0, 65.0, 73.0, 75.0, 64.0, 71.0, 92.0]	223.0	210.13	181.0	232.0	[208.0, 195.0, 209.0, 224.0, 232.0, 202.0, 203.0, 221.0, 209.0, 221.0, 210.0, 226.0, 208.0, 218.0, 204.0, 215.0, 213.0, 190.0, 203.0, 217.0, 204.0, 206.0, 220.0, 214.0, 224.0, 199.0, 221.0, 202.0, 208.0, 220.0, 205.0, 220.0, 210.0, 220.0, 217.0, 193.0, 231.0, 204.0, 203.0, 206.0, 223.0, 205.0, 187.0, 207.0, 193.0, 212.0, 220.0, 216.0, 213.0, 204.0, 209.0, 213.0, 199.0, 212.0, 227.0, 208.0, 216.0, 201.0, 207.0, 200.0, 202.0, 211.0, 218.0, 205.0, 209.0, 216.0, 209.0, 199.0, 215.0, 199.0, 216.0, 199.0, 214.0, 224.0, 223.0, 209.0, 201.0, 219.0, 207.0, 232.0, 181.0, 220.0, 211.0, 208.0, 208.0, 205.0, 201.0, 205.0, 213.0, 205.0, 219.0, 211.0, 226.0, 196.0, 214.0, 209.0, 220.0, 205.0, 212.0, 190.0]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS85	T>A	Intergenic	['Lymph-BNHL']	1	[]	0	[]	0	[]	0	[]	0	[]	0	['Lymph-BNHL']	1	1.1