# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	22.693
E:A[C>A]A	23.908
A:A[C>G]A	937.112
E:A[C>G]A	975.989
A:A[C>T]A	1981.992
E:A[C>T]A	2086.429
A:A[T>A]A	51.758
E:A[T>A]A	53.306
A:A[T>C]A	2776.165
E:A[T>C]A	2834.411
A:A[T>G]A	1823.864
E:A[T>G]A	1850.691
A:A[C>A]C	437.915
E:A[C>A]C	449.096
A:A[C>G]C	1415.26
E:A[C>G]C	1503.161
A:A[C>T]C	488.498
E:A[C>T]C	508.255
A:A[T>A]C	504.395
E:A[T>A]C	514.969
A:A[T>C]C	1691.781
E:A[T>C]C	1716.173
A:A[T>G]C	1319.335
E:A[T>G]C	1348.597
A:A[C>A]G	92.561
E:A[C>A]G	90.976
A:A[C>G]G	425.951
E:A[C>G]G	433.166
A:A[C>T]G	1199.638
E:A[C>T]G	1201.93
A:A[T>A]G	1886.975
E:A[T>A]G	1883.522
A:A[T>C]G	3632.098
E:A[T>C]G	3598.034
A:A[T>G]G	5900.128
E:A[T>G]G	5818.245
A:A[C>A]T	1888.612
E:A[C>A]T	1927.3
A:A[C>G]T	1656.732
E:A[C>G]T	1645.136
A:A[C>T]T	12082.212
E:A[C>T]T	12177.451
A:A[T>A]T	19963.316
E:A[T>A]T	19669.956
A:A[T>C]T	18206.959
E:A[T>C]T	18022.311
A:A[T>G]T	7687.316
E:A[T>G]T	7443.331
A:C[C>A]A	11483.699
E:C[C>A]A	12012.446
A:C[C>G]A	805.149
E:C[C>G]A	861.835
A:C[C>T]A	13868.976
E:C[C>T]A	14313.675
A:C[T>A]A	900.313
E:C[T>A]A	906.137
A:C[T>C]A	4661.635
E:C[T>C]A	4680.487
A:C[T>G]A	713.853
E:C[T>G]A	707.094
A:C[C>A]C	1496.54
E:C[C>A]C	1541.246
A:C[C>G]C	93.444
E:C[C>G]C	95.735
A:C[C>T]C	997.414
E:C[C>T]C	1012.961
A:C[T>A]C	34.73
E:C[T>A]C	34.406
A:C[T>C]C	50.406
E:C[T>C]C	50.072
A:C[T>G]C	20.346
E:C[T>G]C	20.769
A:C[C>A]G	52.891
E:C[C>A]G	54.321
A:C[C>G]G	645.009
E:C[C>G]G	618.696
A:C[C>T]G	901.833
E:C[C>T]G	903.481
A:C[T>A]G	763.676
E:C[T>A]G	741.123
A:C[T>C]G	529.904
E:C[T>C]G	514.046
A:C[T>G]G	27.923
E:C[T>G]G	26.205
A:C[C>A]T	72.628
E:C[C>A]T	70.248
A:C[C>G]T	0.0
E:C[C>G]T	0.0
A:C[C>T]T	52.665
E:C[C>T]T	51.672
A:C[T>A]T	481.538
E:C[T>A]T	462.545
A:C[T>C]T	17975.873
E:C[T>C]T	17452.897
A:C[T>G]T	354.154
E:C[T>G]T	334.013
A:G[C>A]A	88.687
E:G[C>A]A	93.066
A:G[C>G]A	151.471
E:G[C>G]A	155.31
A:G[C>T]A	250.781
E:G[C>T]A	262.355
A:G[T>A]A	12.817
E:G[T>A]A	13.014
A:G[T>C]A	753.964
E:G[T>C]A	742.739
A:G[T>G]A	38.897
E:G[T>G]A	39.73
A:G[C>A]C	0.0
E:G[C>A]C	0.0
A:G[C>G]C	0.0
E:G[C>G]C	0.0
A:G[C>T]C	61.509
E:G[C>T]C	62.049
A:G[T>A]C	48.099
E:G[T>A]C	47.796
A:G[T>C]C	1503.297
E:G[T>C]C	1445.483
A:G[T>G]C	12.436
E:G[T>G]C	11.948
A:G[C>A]G	5.907
E:G[C>A]G	6.157
A:G[C>G]G	218.555
E:G[C>G]G	220.292
A:G[C>T]G	264.015
E:G[C>T]G	263.953
A:G[T>A]G	846.845
E:G[T>A]G	825.338
A:G[T>C]G	1593.412
E:G[T>C]G	1523.369
A:G[T>G]G	2762.536
E:G[T>G]G	2599.816
A:G[C>A]T	73.821
E:G[C>A]T	69.803
A:G[C>G]T	534.906
E:G[C>G]T	524.367
A:G[C>T]T	14789.992
E:G[C>T]T	14391.014
A:G[T>A]T	3797.426
E:G[T>A]T	3646.84
A:G[T>C]T	115980.022
E:G[T>C]T	111040.305
A:G[T>G]T	4507.232
E:G[T>G]T	4341.993
A:T[C>A]A	5434.324
E:T[C>A]A	5461.856
A:T[C>G]A	2112.978
E:T[C>G]A	2113.659
A:T[C>T]A	76.675
E:T[C>T]A	77.733
A:T[T>A]A	8938.162
E:T[T>A]A	8754.587
A:T[T>C]A	30400.162
E:T[T>C]A	29757.984
A:T[T>G]A	111.409
E:T[T>G]A	109.004
A:T[C>A]C	3192.135
E:T[C>A]C	3246.349
A:T[C>G]C	296.157
E:T[C>G]C	299.452
A:T[C>T]C	2292.951
E:T[C>T]C	2286.977
A:T[T>A]C	416.472
E:T[T>A]C	410.921
A:T[T>C]C	6157.19
E:T[T>C]C	5972.518
A:T[T>G]C	43.899
E:T[T>G]C	42.365
A:T[C>A]G	0.0
E:T[C>A]G	0.0
A:T[C>G]G	512.095
E:T[C>G]G	524.035
A:T[C>T]G	658.29
E:T[C>T]G	653.336
A:T[T>A]G	2093.692
E:T[T>A]G	2019.02
A:T[T>C]G	9044.381
E:T[T>C]G	8643.91
A:T[T>G]G	89.357
E:T[T>G]G	85.013
A:T[C>A]T	134.025
E:T[C>A]T	130.627
A:T[C>G]T	52.286
E:T[C>G]T	50.011
A:T[C>T]T	21294.078
E:T[C>T]T	20570.208
A:T[T>A]T	10997.936
E:T[T>A]T	10415.753
A:T[T>C]T	15292.833
E:T[T>C]T	14413.245
A:T[T>G]T	163.717
E:T[T>G]T	153.818

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
Skin-Melanoma	SBS7d	C>A	2682.0	2766.0	2682.1	2782.6	0.893371202084078	1.0	1.531	355948.0	Leading	1.031	1.037	0.994							2682.0	2682.1	2540.0	2797.0	[2540, 2647, 2670, 2736, 2747, 2677, 2665, 2691, 2659, 2649, 2651, 2681, 2797, 2760, 2660, 2685, 2614, 2703, 2653, 2687, 2742, 2736, 2763, 2658, 2671, 2713, 2699, 2649, 2673, 2678, 2699, 2694, 2655, 2699, 2677, 2640, 2698, 2659, 2688, 2725, 2676, 2747, 2708, 2722, 2668, 2723, 2663, 2644, 2701, 2707, 2619, 2652, 2673, 2691, 2725, 2666, 2670, 2690, 2691, 2659, 2653, 2607, 2653, 2731, 2709, 2710, 2720, 2735, 2697, 2621, 2704, 2699, 2671, 2654, 2709, 2694, 2663, 2725, 2636, 2704, 2641, 2640, 2727, 2723, 2673, 2679, 2722, 2593, 2685, 2662, 2671, 2675, 2610, 2627, 2650, 2677, 2682, 2673, 2709, 2713]	2766.0	2782.6	2670.0	2915.0	[2915, 2803, 2807, 2746, 2704, 2795, 2822, 2786, 2818, 2779, 2800, 2798, 2670, 2739, 2811, 2779, 2863, 2779, 2773, 2743, 2743, 2743, 2717, 2779, 2785, 2754, 2760, 2804, 2823, 2793, 2755, 2775, 2790, 2750, 2811, 2825, 2761, 2829, 2761, 2721, 2831, 2754, 2746, 2704, 2803, 2724, 2791, 2794, 2808, 2753, 2840, 2793, 2822, 2746, 2747, 2799, 2756, 2802, 2769, 2817, 2822, 2823, 2769, 2728, 2777, 2740, 2771, 2700, 2756, 2859, 2788, 2789, 2783, 2788, 2728, 2805, 2814, 2760, 2823, 2785, 2839, 2841, 2721, 2768, 2757, 2777, 2777, 2843, 2775, 2797, 2792, 2798, 2858, 2809, 2796, 2799, 2800, 2793, 2772, 2732]
Skin-Melanoma	SBS7d	C>G	1317.0	1328.0	1313.47	1358.18	0.6607247455429351	1.0	0.743	355948.0	Leading	1.008	1.034	0.975							1317.0	1313.47	1241.0	1381.0	[1241, 1350, 1319, 1308, 1303, 1334, 1311, 1277, 1301, 1330, 1312, 1324, 1321, 1350, 1361, 1348, 1336, 1323, 1287, 1334, 1279, 1339, 1297, 1297, 1326, 1280, 1339, 1305, 1347, 1325, 1353, 1311, 1364, 1321, 1301, 1355, 1353, 1321, 1331, 1346, 1322, 1277, 1295, 1304, 1347, 1339, 1285, 1280, 1302, 1335, 1309, 1344, 1297, 1301, 1311, 1317, 1244, 1328, 1365, 1344, 1308, 1278, 1293, 1302, 1293, 1302, 1274, 1330, 1278, 1325, 1327, 1312, 1340, 1328, 1291, 1289, 1292, 1284, 1311, 1322, 1259, 1381, 1335, 1288, 1350, 1290, 1281, 1261, 1329, 1338, 1298, 1289, 1308, 1311, 1266, 1294, 1324, 1257, 1364, 1339]	1328.0	1358.18	1295.0	1424.0	[1409, 1327, 1336, 1353, 1363, 1362, 1350, 1392, 1347, 1357, 1360, 1347, 1355, 1314, 1357, 1327, 1358, 1338, 1376, 1335, 1424, 1366, 1375, 1362, 1340, 1392, 1348, 1359, 1317, 1333, 1301, 1373, 1307, 1342, 1359, 1342, 1342, 1334, 1362, 1342, 1366, 1397, 1365, 1378, 1326, 1325, 1370, 1399, 1381, 1337, 1371, 1335, 1372, 1363, 1354, 1360, 1423, 1350, 1336, 1343, 1363, 1410, 1401, 1363, 1381, 1371, 1400, 1320, 1370, 1334, 1338, 1339, 1324, 1364, 1388, 1384, 1373, 1386, 1361, 1327, 1409, 1307, 1326, 1364, 1331, 1397, 1362, 1398, 1350, 1328, 1351, 1391, 1379, 1358, 1383, 1343, 1351, 1415, 1295, 1349]
Skin-Melanoma	SBS7d	C>T	0.0	0.0	0.0	0.0	1.0	1.0	0.0	355948.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Skin-Melanoma	SBS7d	T>A	603.0	523.0	580.87	547.39	0.33197489442596684	0.7164979135535144	0.316	355948.0	Lagging	1.153	1.061	1.087							603.0	580.87	531.0	636.0	[603, 577, 538, 565, 586, 598, 601, 564, 582, 586, 586, 636, 596, 560, 589, 567, 596, 594, 612, 593, 552, 558, 588, 589, 570, 576, 544, 558, 571, 609, 548, 579, 610, 597, 595, 573, 555, 589, 585, 556, 555, 579, 574, 599, 595, 548, 569, 560, 578, 584, 551, 604, 568, 595, 565, 595, 612, 578, 602, 573, 552, 576, 603, 602, 609, 587, 572, 576, 584, 593, 575, 589, 588, 557, 600, 560, 584, 619, 603, 570, 589, 588, 540, 596, 570, 550, 592, 579, 592, 550, 594, 531, 607, 578, 575, 613, 585, 593, 588, 563]	523.0	547.39	507.0	602.0	[553, 544, 592, 555, 545, 543, 542, 557, 562, 560, 537, 507, 524, 571, 539, 543, 549, 530, 520, 542, 564, 562, 538, 552, 540, 548, 587, 557, 561, 518, 579, 550, 534, 538, 513, 549, 537, 520, 540, 575, 576, 566, 559, 515, 531, 580, 559, 554, 561, 538, 570, 525, 556, 523, 568, 539, 531, 556, 531, 567, 576, 551, 511, 534, 515, 524, 564, 545, 556, 533, 545, 527, 547, 561, 536, 576, 533, 544, 514, 562, 535, 544, 559, 525, 554, 566, 537, 555, 542, 573, 537, 602, 540, 548, 555, 539, 552, 531, 554, 555]
Skin-Melanoma	SBS7d	T>C	169928.0	163269.0	170059.09	163571.86	0.8274129537069563	1.0	93.608	355948.0	Lagging	1.041	1.04	1.001							169928.0	170059.09	169015.0	170866.0	[170397, 169876, 169518, 170167, 169960, 170464, 170498, 170199, 169506, 170396, 169921, 170101, 170337, 169015, 170574, 170026, 170061, 170154, 169909, 170630, 169969, 170265, 170866, 170292, 170595, 170325, 169414, 170605, 169815, 169828, 169746, 169684, 169865, 170174, 169481, 170289, 169706, 170631, 170043, 170126, 169670, 169651, 169834, 169943, 169650, 170281, 169922, 169809, 170323, 170279, 170063, 170142, 170249, 169940, 170398, 170447, 170366, 170404, 169722, 169994, 170345, 170119, 169787, 169931, 170460, 169932, 170567, 170100, 169608, 169666, 169796, 170291, 170208, 169949, 170010, 170022, 170044, 170150, 169532, 169927, 169797, 170191, 170142, 169934, 170278, 170011, 169941, 169768, 170196, 170121, 170688, 170298, 169696, 169692, 169775, 170347, 170027, 169901, 169844, 170303]	163269.0	163571.86	162877.0	164485.0	[163205, 163857, 164064, 163356, 163763, 163336, 163148, 163182, 164012, 163392, 164023, 163279, 163625, 164485, 163352, 163678, 163598, 163067, 163835, 163028, 163702, 163290, 163024, 163247, 163098, 163552, 164175, 163528, 163535, 163594, 163625, 163718, 163680, 163080, 164013, 163074, 163833, 163421, 163526, 163808, 163886, 163790, 164039, 163621, 163964, 163474, 163967, 163586, 163486, 163362, 163483, 163261, 163456, 163523, 163557, 163255, 163454, 163249, 163545, 163701, 163137, 163470, 163632, 163689, 163333, 163665, 162877, 163425, 164126, 163928, 163936, 163500, 163182, 163770, 163473, 163725, 163718, 163344, 164176, 163643, 163763, 163382, 163470, 163664, 163333, 163577, 163683, 163767, 163509, 163825, 163175, 163168, 163897, 164032, 163855, 163087, 163717, 164039, 163861, 163166]
Skin-Melanoma	SBS7d	T>G	6940.0	6592.0	6824.47	6714.11	0.14799116629556774	0.3925934672080308	3.802	355948.0	Lagging	1.053	1.016	1.036							6940.0	6824.47	6627.0	6973.0	[6803, 6756, 6850, 6874, 6795, 6813, 6845, 6856, 6846, 6973, 6863, 6873, 6885, 6870, 6831, 6705, 6799, 6855, 6795, 6812, 6730, 6812, 6796, 6731, 6857, 6759, 6847, 6832, 6875, 6827, 6854, 6852, 6787, 6807, 6773, 6825, 6824, 6854, 6720, 6809, 6822, 6627, 6834, 6967, 6934, 6851, 6892, 6812, 6787, 6859, 6832, 6769, 6807, 6901, 6739, 6875, 6846, 6777, 6941, 6722, 6805, 6744, 6854, 6917, 6670, 6703, 6782, 6833, 6913, 6724, 6891, 6874, 6835, 6920, 6784, 6899, 6837, 6853, 6805, 6806, 6844, 6840, 6795, 6908, 6896, 6831, 6868, 6950, 6764, 6773, 6803, 6831, 6854, 6823, 6801, 6758, 6833, 6775, 6885, 6702]	6592.0	6714.11	6545.0	6929.0	[6729, 6747, 6667, 6700, 6752, 6699, 6640, 6741, 6723, 6567, 6684, 6640, 6623, 6701, 6714, 6826, 6709, 6671, 6652, 6694, 6809, 6775, 6742, 6741, 6736, 6731, 6758, 6658, 6685, 6714, 6745, 6719, 6729, 6670, 6757, 6684, 6655, 6651, 6842, 6742, 6717, 6929, 6712, 6642, 6694, 6655, 6636, 6760, 6782, 6675, 6704, 6767, 6756, 6691, 6788, 6708, 6769, 6780, 6614, 6806, 6679, 6780, 6722, 6675, 6835, 6737, 6779, 6682, 6630, 6776, 6655, 6703, 6691, 6566, 6769, 6622, 6726, 6617, 6728, 6738, 6655, 6727, 6761, 6696, 6678, 6650, 6594, 6545, 6743, 6756, 6743, 6712, 6674, 6758, 6739, 6796, 6819, 6726, 6649, 6873]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change