# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types.
MutationType	Across_All_Cancer_Types
T:A[C>A]A	0.0
U:A[C>A]A	0.0
B:A[C>A]A	0.0
N:A[C>A]A	2.5
T:A[C>A]C	58.5
U:A[C>A]C	40.0
B:A[C>A]C	0.0
N:A[C>A]C	271.5
T:A[C>A]G	6.0
U:A[C>A]G	3.0
B:A[C>A]G	0.0
N:A[C>A]G	25.5
T:A[C>A]T	328.5
U:A[C>A]T	274.5
B:A[C>A]T	0.0
N:A[C>A]T	1395.5
T:A[C>G]A	172.0
U:A[C>G]A	115.5
B:A[C>G]A	0.0
N:A[C>G]A	636.0
T:A[C>G]C	272.5
U:A[C>G]C	231.0
B:A[C>G]C	0.0
N:A[C>G]C	977.0
T:A[C>G]G	52.0
U:A[C>G]G	61.0
B:A[C>G]G	0.0
N:A[C>G]G	233.5
T:A[C>G]T	269.0
U:A[C>G]T	262.5
B:A[C>G]T	0.0
N:A[C>G]T	1128.0
T:A[C>T]A	377.0
U:A[C>T]A	325.5
B:A[C>T]A	0.5
N:A[C>T]A	1419.0
T:A[C>T]C	38.0
U:A[C>T]C	63.5
B:A[C>T]C	0.0
N:A[C>T]C	316.0
T:A[C>T]G	212.5
U:A[C>T]G	212.5
B:A[C>T]G	0.0
N:A[C>T]G	781.0
T:A[C>T]T	2052.5
U:A[C>T]T	2185.0
B:A[C>T]T	8.0
N:A[C>T]T	9075.0
T:A[T>A]A	0.5
U:A[T>A]A	0.0
B:A[T>A]A	0.0
N:A[T>A]A	14.0
T:A[T>A]C	58.5
U:A[T>A]C	46.0
B:A[T>A]C	0.0
N:A[T>A]C	331.5
T:A[T>A]G	317.0
U:A[T>A]G	291.5
B:A[T>A]G	0.0
N:A[T>A]G	1345.0
T:A[T>A]T	3032.5
U:A[T>A]T	3476.0
B:A[T>A]T	14.5
N:A[T>A]T	15445.0
T:A[T>C]A	534.0
U:A[T>C]A	474.5
B:A[T>C]A	1.5
N:A[T>C]A	1948.5
T:A[T>C]C	325.5
U:A[T>C]C	262.5
B:A[T>C]C	0.5
N:A[T>C]C	1160.5
T:A[T>C]G	696.5
U:A[T>C]G	643.5
B:A[T>C]G	2.0
N:A[T>C]G	2549.0
T:A[T>C]T	3221.5
U:A[T>C]T	3437.5
B:A[T>C]T	28.5
N:A[T>C]T	13390.5
T:A[T>G]A	271.5
U:A[T>G]A	251.5
B:A[T>G]A	0.0
N:A[T>G]A	1379.0
T:A[T>G]C	179.0
U:A[T>G]C	221.5
B:A[T>G]C	0.0
N:A[T>G]C	933.0
T:A[T>G]G	820.5
U:A[T>G]G	1233.5
B:A[T>G]G	2.5
N:A[T>G]G	4284.5
T:A[T>G]T	1176.0
U:A[T>G]T	1403.0
B:A[T>G]T	4.0
N:A[T>G]T	5687.5
T:C[C>A]A	2236.5
U:C[C>A]A	1835.5
B:C[C>A]A	8.5
N:C[C>A]A	8758.5
T:C[C>A]C	230.5
U:C[C>A]C	256.5
B:C[C>A]C	0.0
N:C[C>A]C	1047.5
T:C[C>A]G	0.0
U:C[C>A]G	0.5
B:C[C>A]G	0.0
N:C[C>A]G	10.0
T:C[C>A]T	0.0
U:C[C>A]T	0.0
B:C[C>A]T	0.0
N:C[C>A]T	17.5
T:C[C>G]A	143.0
U:C[C>G]A	118.5
B:C[C>G]A	0.0
N:C[C>G]A	548.0
T:C[C>G]C	3.0
U:C[C>G]C	3.5
B:C[C>G]C	0.0
N:C[C>G]C	32.0
T:C[C>G]G	76.5
U:C[C>G]G	135.0
B:C[C>G]G	0.0
N:C[C>G]G	350.5
T:C[C>G]T	0.0
U:C[C>G]T	0.0
B:C[C>G]T	0.0
N:C[C>G]T	0.0
T:C[C>T]A	2104.5
U:C[C>T]A	2753.0
B:C[C>T]A	10.0
N:C[C>T]A	10573.5
T:C[C>T]C	105.5
U:C[C>T]C	181.0
B:C[C>T]C	0.0
N:C[C>T]C	667.5
T:C[C>T]G	107.5
U:C[C>T]G	190.0
B:C[C>T]G	0.0
N:C[C>T]G	548.5
T:C[C>T]T	0.0
U:C[C>T]T	1.0
B:C[C>T]T	0.0
N:C[C>T]T	11.5
T:C[T>A]A	150.0
U:C[T>A]A	118.0
B:C[T>A]A	0.5
N:C[T>A]A	581.5
T:C[T>A]C	0.0
U:C[T>A]C	0.0
B:C[T>A]C	0.0
N:C[T>A]C	5.5
T:C[T>A]G	114.5
U:C[T>A]G	111.0
B:C[T>A]G	0.0
N:C[T>A]G	480.5
T:C[T>A]T	29.5
U:C[T>A]T	47.5
B:C[T>A]T	0.0
N:C[T>A]T	316.0
T:C[T>C]A	843.0
U:C[T>C]A	896.0
B:C[T>C]A	4.5
N:C[T>C]A	3274.0
T:C[T>C]C	1.0
U:C[T>C]C	1.0
B:C[T>C]C	0.0
N:C[T>C]C	8.5
T:C[T>C]G	72.0
U:C[T>C]G	88.5
B:C[T>C]G	0.0
N:C[T>C]G	301.5
T:C[T>C]T	2676.0
U:C[T>C]T	3432.0
B:C[T>C]T	19.0
N:C[T>C]T	13416.0
T:C[T>G]A	91.0
U:C[T>G]A	95.0
B:C[T>G]A	0.0
N:C[T>G]A	463.5
T:C[T>G]C	0.0
U:C[T>G]C	0.0
B:C[T>G]C	0.0
N:C[T>G]C	1.0
T:C[T>G]G	0.0
U:C[T>G]G	0.5
B:C[T>G]G	0.0
N:C[T>G]G	4.0
T:C[T>G]T	28.0
U:C[T>G]T	42.0
B:C[T>G]T	0.0
N:C[T>G]T	218.0
T:G[C>A]A	4.0
U:G[C>A]A	1.5
B:G[C>A]A	0.0
N:G[C>A]A	34.5
T:G[C>A]C	0.0
U:G[C>A]C	0.0
B:G[C>A]C	0.0
N:G[C>A]C	0.0
T:G[C>A]G	0.0
U:G[C>A]G	0.0
B:G[C>A]G	0.0
N:G[C>A]G	0.0
T:G[C>A]T	3.0
U:G[C>A]T	3.0
B:G[C>A]T	0.0
N:G[C>A]T	28.0
T:G[C>G]A	13.0
U:G[C>G]A	10.0
B:G[C>G]A	0.0
N:G[C>G]A	76.0
T:G[C>G]C	0.0
U:G[C>G]C	0.0
B:G[C>G]C	0.0
N:G[C>G]C	0.0
T:G[C>G]G	19.0
U:G[C>G]G	24.0
B:G[C>G]G	0.0
N:G[C>G]G	95.5
T:G[C>G]T	53.5
U:G[C>G]T	77.5
B:G[C>G]T	0.0
N:G[C>G]T	341.5
T:G[C>T]A	27.5
U:G[C>T]A	28.5
B:G[C>T]A	0.0
N:G[C>T]A	133.0
T:G[C>T]C	0.0
U:G[C>T]C	1.0
B:G[C>T]C	0.0
N:G[C>T]C	12.0
T:G[C>T]G	33.0
U:G[C>T]G	42.5
B:G[C>T]G	0.0
N:G[C>T]G	150.0
T:G[C>T]T	2154.0
U:G[C>T]T	2675.5
B:G[C>T]T	9.0
N:G[C>T]T	11124.5
T:G[T>A]A	0.0
U:G[T>A]A	0.0
B:G[T>A]A	0.0
N:G[T>A]A	0.0
T:G[T>A]C	0.0
U:G[T>A]C	0.0
B:G[T>A]C	0.0
N:G[T>A]C	9.5
T:G[T>A]G	156.5
U:G[T>A]G	131.5
B:G[T>A]G	0.0
N:G[T>A]G	504.0
T:G[T>A]T	489.0
U:G[T>A]T	689.0
B:G[T>A]T	0.5
N:G[T>A]T	2794.0
T:G[T>C]A	113.5
U:G[T>C]A	134.0
B:G[T>C]A	0.5
N:G[T>C]A	455.5
T:G[T>C]C	279.0
U:G[T>C]C	276.0
B:G[T>C]C	0.0
N:G[T>C]C	945.5
T:G[T>C]G	290.0
U:G[T>C]G	319.0
B:G[T>C]G	0.0
N:G[T>C]G	972.5
T:G[T>C]T	16059.5
U:G[T>C]T	27134.0
B:G[T>C]T	307.5
N:G[T>C]T	82944.5
T:G[T>G]A	0.0
U:G[T>G]A	0.5
B:G[T>G]A	0.0
N:G[T>G]A	5.0
T:G[T>G]C	0.0
U:G[T>G]C	0.0
B:G[T>G]C	0.0
N:G[T>G]C	0.5
T:G[T>G]G	339.0
U:G[T>G]G	661.5
B:G[T>G]G	1.5
N:G[T>G]G	1800.0
T:G[T>G]T	580.0
U:G[T>G]T	871.5
B:G[T>G]T	0.5
N:G[T>G]T	3332.0
T:T[C>A]A	1110.5
U:T[C>A]A	934.0
B:T[C>A]A	3.5
N:T[C>A]A	3835.0
T:T[C>A]C	606.5
U:T[C>A]C	605.0
B:T[C>A]C	1.0
N:T[C>A]C	2207.0
T:T[C>A]G	0.0
U:T[C>A]G	0.0
B:T[C>A]G	0.0
N:T[C>A]G	0.0
T:T[C>A]T	4.0
U:T[C>A]T	7.0
B:T[C>A]T	0.0
N:T[C>A]T	59.5
T:T[C>G]A	372.5
U:T[C>G]A	359.0
B:T[C>G]A	1.5
N:T[C>G]A	1419.0
T:T[C>G]C	24.5
U:T[C>G]C	30.0
B:T[C>G]C	0.0
N:T[C>G]C	162.5
T:T[C>G]G	63.0
U:T[C>G]G	97.5
B:T[C>G]G	0.0
N:T[C>G]G	284.5
T:T[C>G]T	0.5
U:T[C>G]T	0.5
B:T[C>G]T	0.0
N:T[C>G]T	10.5
T:T[C>T]A	1.0
U:T[C>T]A	1.0
B:T[C>T]A	0.0
N:T[C>T]A	27.0
T:T[C>T]C	262.5
U:T[C>T]C	382.5
B:T[C>T]C	0.0
N:T[C>T]C	1732.5
T:T[C>T]G	48.5
U:T[C>T]G	93.5
B:T[C>T]G	0.0
N:T[C>T]G	439.0
T:T[C>T]T	2904.5
U:T[C>T]T	3914.5
B:T[C>T]T	17.0
N:T[C>T]T	16195.5
T:T[T>A]A	1539.5
U:T[T>A]A	1755.0
B:T[T>A]A	10.0
N:T[T>A]A	6361.5
T:T[T>A]C	28.5
U:T[T>A]C	42.5
B:T[T>A]C	0.0
N:T[T>A]C	269.0
T:T[T>A]G	275.5
U:T[T>A]G	402.0
B:T[T>A]G	0.0
N:T[T>A]G	1452.0
T:T[T>A]T	1299.0
U:T[T>A]T	2050.0
B:T[T>A]T	3.0
N:T[T>A]T	8390.5
T:T[T>C]A	4819.5
U:T[T>C]A	6275.5
B:T[T>C]A	45.5
N:T[T>C]A	22304.0
T:T[T>C]C	926.5
U:T[T>C]C	1198.5
B:T[T>C]C	3.5
N:T[T>C]C	4438.5
T:T[T>C]G	1361.5
U:T[T>C]G	1925.5
B:T[T>C]G	10.0
N:T[T>C]G	6385.5
T:T[T>C]T	2143.0
U:T[T>C]T	3144.0
B:T[T>C]T	13.5
N:T[T>C]T	11078.0
T:T[T>G]A	1.5
U:T[T>G]A	4.5
B:T[T>G]A	0.0
N:T[T>G]A	43.0
T:T[T>G]C	0.5
U:T[T>G]C	0.5
B:T[T>G]C	0.0
N:T[T>G]C	8.0
T:T[T>G]G	0.5
U:T[T>G]G	3.5
B:T[T>G]G	0.0
N:T[T>G]G	29.0
T:T[T>G]T	3.5
U:T[T>G]T	10.0
B:T[T>G]T	0.0
N:T[T>G]T	80.0

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	genic_real_count	intergenic_real_count	genic_mean_sims_count	intergenic_mean_sims_count	genic_versus_intergenic_p_value	genic_versus_intergenic_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Transcribed_real_count	Transcribed_mean_sims_count	Transcribed_min_sims_count	Transcribed_max_sims_count	Transcribed_sims_count_list	UnTranscribed_real_count	UnTranscribed_mean_sims_count	UnTranscribed_min_sims_count	UnTranscribed_max_sims_count	UnTranscribed_sims_count_list	NonTranscribed_real_count	NonTranscribed_mean_sims_count	NonTranscribed_min_sims_count	NonTranscribed_max_sims_count	NonTranscribed_sims_count_list
Skin-Melanoma	SBS7d	C>A	2042.0	4050.0	2672.15	3435.05	3.4839011933952627e-31	3.518459998798915e-30	1.53	398146.0	Intergenic	1.983	1.286	1.543	1	1	1	1			1135.0	1405.97	1319.0	1466.0	[1416, 1383, 1450, 1420, 1360, 1448, 1429, 1378, 1407, 1450, 1410, 1398, 1466, 1374, 1400, 1407, 1426, 1428, 1425, 1423, 1459, 1391, 1372, 1443, 1423, 1414, 1463, 1418, 1403, 1454, 1409, 1348, 1419, 1381, 1454, 1402, 1448, 1436, 1419, 1365, 1364, 1398, 1454, 1384, 1447, 1428, 1354, 1392, 1422, 1407, 1340, 1409, 1345, 1350, 1425, 1395, 1427, 1344, 1371, 1436, 1382, 1431, 1446, 1429, 1406, 1372, 1429, 1406, 1447, 1382, 1323, 1406, 1464, 1319, 1401, 1382, 1438, 1369, 1425, 1435, 1419, 1395, 1439, 1322, 1337, 1404, 1386, 1406, 1396, 1462, 1415, 1409, 1388, 1460, 1362, 1346, 1405, 1401, 1428, 1414]	907.0	1266.18	1193.0	1364.0	[1233, 1276, 1308, 1273, 1249, 1297, 1270, 1267, 1290, 1271, 1264, 1288, 1264, 1279, 1265, 1245, 1304, 1269, 1278, 1271, 1261, 1324, 1302, 1287, 1273, 1265, 1210, 1225, 1268, 1250, 1278, 1291, 1245, 1217, 1236, 1215, 1226, 1208, 1267, 1324, 1303, 1277, 1246, 1202, 1250, 1271, 1215, 1253, 1285, 1273, 1261, 1279, 1299, 1255, 1256, 1240, 1244, 1312, 1267, 1263, 1247, 1294, 1232, 1211, 1260, 1257, 1276, 1280, 1280, 1261, 1364, 1292, 1281, 1315, 1219, 1286, 1235, 1193, 1220, 1248, 1287, 1254, 1234, 1271, 1292, 1256, 1279, 1269, 1243, 1290, 1244, 1271, 1304, 1263, 1343, 1290, 1259, 1303, 1280, 1251]	4050.0	3435.05	3347.0	3538.0	[3455, 3442, 3347, 3415, 3487, 3365, 3412, 3456, 3412, 3393, 3438, 3424, 3373, 3451, 3443, 3460, 3374, 3417, 3403, 3410, 3393, 3400, 3433, 3373, 3411, 3426, 3437, 3460, 3430, 3407, 3425, 3465, 3438, 3507, 3417, 3483, 3438, 3471, 3426, 3417, 3433, 3432, 3409, 3522, 3413, 3411, 3536, 3464, 3399, 3422, 3503, 3413, 3458, 3497, 3423, 3472, 3438, 3454, 3465, 3402, 3478, 3387, 3429, 3467, 3445, 3472, 3398, 3420, 3389, 3465, 3425, 3413, 3369, 3471, 3482, 3446, 3439, 3538, 3461, 3414, 3404, 3457, 3439, 3513, 3482, 3458, 3431, 3438, 3466, 3363, 3453, 3425, 3419, 3386, 3405, 3476, 3447, 3403, 3396, 3436]
Skin-Melanoma	SBS7d	C>G	1066.0	1914.0	1303.15	1679.97	4.145167249269551e-10	2.58238892414527e-09	0.748	398146.0	Intergenic	1.795	1.289	1.393	1	1	1				547.0	675.97	601.0	736.0	[676, 651, 653, 668, 710, 702, 673, 709, 700, 682, 671, 673, 665, 669, 694, 644, 677, 649, 694, 736, 664, 652, 654, 647, 685, 670, 697, 704, 652, 651, 650, 652, 659, 690, 680, 696, 708, 704, 672, 684, 695, 722, 673, 675, 683, 698, 668, 666, 674, 670, 658, 679, 663, 631, 663, 645, 662, 717, 667, 601, 704, 624, 697, 700, 675, 671, 690, 685, 704, 685, 637, 683, 633, 651, 688, 658, 694, 699, 680, 685, 638, 647, 701, 659, 641, 667, 694, 687, 710, 697, 703, 677, 657, 666, 687, 681, 672, 698, 728, 667]	519.0	627.18	575.0	673.0	[652, 664, 629, 643, 606, 607, 647, 626, 608, 618, 597, 630, 639, 611, 617, 628, 631, 607, 623, 628, 630, 650, 662, 601, 624, 602, 617, 622, 639, 619, 596, 636, 638, 610, 649, 630, 646, 628, 624, 626, 597, 608, 636, 625, 637, 589, 611, 661, 632, 648, 625, 614, 608, 673, 641, 652, 637, 647, 625, 621, 606, 662, 635, 610, 636, 650, 605, 636, 628, 648, 650, 633, 645, 642, 605, 624, 610, 615, 645, 604, 630, 634, 609, 609, 635, 637, 645, 649, 575, 613, 618, 633, 617, 641, 620, 639, 633, 614, 617, 614]	1914.0	1679.97	1623.0	1756.0	[1654, 1663, 1697, 1668, 1672, 1676, 1663, 1655, 1676, 1683, 1716, 1679, 1674, 1704, 1674, 1712, 1670, 1724, 1663, 1623, 1683, 1678, 1666, 1733, 1673, 1709, 1668, 1658, 1687, 1710, 1735, 1695, 1684, 1681, 1658, 1653, 1631, 1649, 1683, 1674, 1694, 1653, 1673, 1685, 1671, 1694, 1699, 1661, 1676, 1669, 1707, 1686, 1709, 1687, 1682, 1690, 1685, 1629, 1691, 1756, 1672, 1703, 1656, 1676, 1670, 1661, 1695, 1662, 1655, 1652, 1699, 1668, 1710, 1690, 1686, 1698, 1677, 1668, 1661, 1691, 1715, 1699, 1670, 1715, 1702, 1678, 1644, 1643, 1707, 1671, 1662, 1673, 1706, 1676, 1676, 1660, 1681, 1676, 1640, 1702]
Skin-Melanoma	SBS7d	C>T	0.0	0.0	0.0	0.0	1.0	1.0	0.0	398146.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Skin-Melanoma	SBS7d	T>A	338.0	922.0	527.49	736.76	3.654771640887625e-15	2.726242528955185e-14	0.316	398146.0	Intergenic	2.728	1.397	1.953	1	1	1	1	1		146.0	234.75	203.0	272.0	[242, 231, 259, 225, 240, 228, 212, 225, 227, 236, 232, 243, 231, 245, 218, 220, 240, 215, 240, 218, 228, 265, 265, 271, 235, 233, 213, 222, 229, 247, 234, 241, 259, 272, 231, 229, 209, 220, 223, 232, 224, 246, 222, 229, 216, 235, 246, 259, 228, 235, 232, 227, 212, 244, 219, 240, 203, 236, 241, 240, 230, 248, 225, 237, 236, 230, 236, 241, 268, 219, 246, 227, 237, 231, 235, 237, 241, 212, 238, 260, 254, 241, 239, 220, 232, 225, 251, 239, 233, 226, 220, 251, 234, 231, 242, 265, 222, 208, 253, 236]	192.0	292.74	240.0	336.0	[293, 313, 279, 296, 273, 311, 328, 269, 298, 336, 289, 274, 286, 298, 316, 287, 292, 305, 277, 302, 313, 272, 284, 278, 302, 300, 289, 285, 292, 265, 285, 319, 307, 240, 271, 312, 288, 300, 287, 282, 300, 254, 303, 320, 273, 291, 306, 264, 304, 300, 274, 308, 276, 264, 300, 261, 312, 298, 292, 297, 307, 277, 290, 304, 293, 304, 306, 286, 280, 281, 314, 309, 268, 306, 293, 312, 282, 283, 288, 300, 272, 298, 305, 298, 295, 318, 297, 263, 301, 282, 289, 275, 297, 315, 279, 285, 293, 317, 299, 323]	922.0	736.76	693.0	775.0	[727, 724, 724, 744, 750, 725, 725, 770, 742, 693, 744, 745, 746, 719, 731, 757, 728, 745, 751, 744, 724, 725, 718, 715, 726, 734, 760, 757, 746, 749, 747, 703, 698, 749, 766, 725, 767, 744, 753, 752, 739, 764, 739, 714, 775, 741, 712, 738, 734, 728, 757, 732, 775, 755, 744, 766, 747, 728, 729, 730, 726, 748, 751, 725, 738, 729, 724, 741, 714, 761, 706, 727, 760, 726, 736, 712, 746, 773, 738, 707, 735, 726, 719, 745, 736, 725, 715, 761, 728, 754, 756, 737, 731, 717, 740, 720, 747, 742, 709, 706]
Skin-Melanoma	SBS7d	T>C	128544.0	244141.0	159419.87	213881.04	0.0	0.0	93.605	398146.0	Intergenic	1.899	1.342	1.416	1	1	1				49636.0	71594.02	71159.0	72507.0	[71735, 71669, 71684, 71915, 71715, 71312, 71733, 71551, 71716, 71780, 71571, 71517, 71160, 71583, 71593, 71629, 71623, 71354, 71342, 71641, 71847, 71824, 71373, 72005, 71679, 71331, 71411, 71950, 71591, 71491, 72014, 71778, 71717, 71746, 71810, 71213, 71871, 71512, 71314, 71560, 71501, 71574, 71640, 71800, 71644, 71381, 71951, 71578, 71644, 71688, 71481, 71191, 71394, 71469, 71613, 71232, 71676, 71475, 71542, 71823, 71426, 71159, 71384, 72507, 71654, 71568, 71633, 71660, 71396, 72252, 71523, 71640, 71548, 71486, 71636, 71739, 71459, 71833, 71396, 71517, 71424, 71384, 71436, 71589, 71514, 71302, 71705, 71201, 71948, 71417, 71187, 72095, 71333, 71839, 71670, 71381, 71546, 71715, 71476, 71667]	78908.0	87825.85	87150.0	88245.0	[87731, 87959, 87682, 87852, 87784, 87893, 87565, 88110, 87646, 87505, 88060, 87823, 88019, 87941, 88184, 88057, 88103, 87958, 87655, 87680, 87767, 87453, 88245, 87851, 87831, 87589, 88196, 87596, 88040, 87994, 87585, 87764, 87999, 87182, 87666, 87679, 87359, 87620, 87363, 88188, 87713, 88152, 87855, 88092, 87762, 88059, 88097, 87653, 87856, 88072, 87664, 88117, 87797, 88115, 87172, 88038, 87899, 87892, 87621, 87759, 87428, 87738, 87877, 87816, 87639, 87798, 88110, 87832, 87628, 87765, 87839, 88060, 87982, 87696, 87954, 88185, 87999, 87150, 88045, 87832, 87964, 88043, 88051, 88109, 87519, 88025, 87572, 88004, 87513, 87699, 87802, 87648, 87948, 87977, 87686, 87889, 87742, 87817, 88139, 87506]	244141.0	213881.04	212971.0	214639.0	[213863, 213673, 213871, 213473, 213755, 214092, 214008, 213680, 213922, 214060, 213657, 213927, 214144, 213836, 213543, 213686, 213579, 213966, 214254, 214011, 213707, 214010, 213671, 213508, 213790, 214322, 213736, 213694, 213607, 213826, 213697, 213725, 213560, 214361, 213811, 214410, 214054, 214187, 214639, 213549, 214129, 213652, 213854, 213356, 213804, 213828, 213285, 214099, 213804, 213549, 214092, 214012, 214108, 213734, 214477, 214008, 213653, 213917, 214111, 213704, 214420, 214373, 214035, 212971, 214028, 213913, 213591, 213773, 214288, 213336, 213952, 213578, 213837, 214123, 213686, 213356, 213955, 214354, 213873, 214026, 213965, 213923, 213878, 213599, 214258, 213970, 214039, 214089, 213856, 214207, 214354, 213528, 214034, 213477, 213947, 214019, 213967, 213745, 213655, 214086]
Skin-Melanoma	SBS7d	T>G	4924.0	10205.0	6241.26	8915.89	9.970748596112147e-55	1.3117512210088865e-53	3.8	398146.0	Intergenic	2.073	1.429	1.451	1	1	1				2179.0	3004.27	2859.0	3157.0	[3030, 2958, 3022, 3050, 2935, 2973, 2932, 3062, 3052, 2944, 3013, 2998, 3003, 3052, 3089, 3006, 2995, 3036, 3000, 3009, 3029, 2986, 2994, 3074, 2964, 3040, 2960, 2940, 2976, 3032, 3045, 3003, 3029, 3025, 2894, 3048, 2927, 2966, 2948, 2972, 3012, 3048, 2975, 3009, 3045, 3043, 2943, 2993, 2991, 3024, 2928, 3037, 3029, 3044, 3074, 2993, 3002, 3013, 3012, 2959, 2956, 3024, 3035, 3076, 2995, 2972, 2915, 3039, 2954, 2956, 3012, 3052, 3026, 3075, 2995, 3029, 2977, 3053, 3019, 3068, 2988, 2972, 3157, 3041, 2992, 3060, 3037, 3014, 2976, 2952, 3000, 2886, 2859, 2988, 3029, 3012, 3024, 3022, 3020, 2985]	2745.0	3236.99	3128.0	3353.0	[3196, 3257, 3204, 3215, 3276, 3271, 3268, 3225, 3221, 3225, 3260, 3201, 3153, 3176, 3265, 3249, 3207, 3179, 3160, 3259, 3189, 3151, 3177, 3238, 3266, 3234, 3297, 3268, 3263, 3291, 3297, 3184, 3218, 3252, 3204, 3163, 3208, 3249, 3349, 3228, 3204, 3254, 3150, 3216, 3145, 3209, 3237, 3275, 3204, 3252, 3203, 3245, 3178, 3231, 3223, 3247, 3236, 3178, 3302, 3188, 3328, 3227, 3312, 3164, 3318, 3338, 3267, 3233, 3308, 3201, 3259, 3353, 3221, 3276, 3277, 3233, 3182, 3308, 3263, 3185, 3210, 3166, 3192, 3327, 3270, 3128, 3292, 3227, 3297, 3264, 3292, 3174, 3224, 3263, 3271, 3301, 3217, 3269, 3226, 3266]	10205.0	8915.89	8758.0	9100.0	[8928, 8948, 8922, 8895, 8934, 8916, 8961, 8881, 8893, 8996, 8891, 8947, 9006, 8925, 8810, 8899, 8950, 8935, 8997, 8889, 8946, 9008, 8989, 8845, 8925, 8880, 8892, 8959, 8927, 8836, 8792, 8976, 8907, 8881, 9052, 8949, 9003, 8936, 8877, 8960, 8944, 8857, 9019, 8912, 8967, 8901, 8968, 8874, 8969, 8877, 9018, 8868, 8943, 8882, 8852, 8913, 8908, 8968, 8850, 9006, 8873, 8904, 8818, 8914, 8835, 8856, 8977, 8896, 8899, 8996, 8882, 8758, 8930, 8809, 8882, 8901, 8994, 8794, 8875, 8924, 8969, 9010, 8818, 8785, 8902, 8961, 8845, 8923, 8879, 8948, 8868, 9100, 9072, 8915, 8869, 8846, 8914, 8859, 8918, 8912]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS7d	T>C	Intergenic	['Skin-Melanoma']	1	['Skin-Melanoma']	1	['Skin-Melanoma']	1	[]	0	[]	0	[]	0	['Skin-Melanoma']	1	1.3