# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on transcribed:T, untranscribed:U, bitranscribed:B and nontranscribed:N strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
T:A[C>A]A	729.5
U:A[C>A]A	428.5
B:A[C>A]A	2.0
N:A[C>A]A	2539.0
T:A[C>A]C	134.0
U:A[C>A]C	100.5
B:A[C>A]C	0.0
N:A[C>A]C	529.5
T:A[C>A]G	17.0
U:A[C>A]G	10.5
B:A[C>A]G	0.0
N:A[C>A]G	73.5
T:A[C>A]T	180.5
U:A[C>A]T	151.5
B:A[C>A]T	0.0
N:A[C>A]T	852.0
T:A[C>G]A	203.0
U:A[C>G]A	135.0
B:A[C>G]A	0.5
N:A[C>G]A	738.0
T:A[C>G]C	24.0
U:A[C>G]C	19.0
B:A[C>G]C	0.0
N:A[C>G]C	123.5
T:A[C>G]G	0.0
U:A[C>G]G	0.0
B:A[C>G]G	0.0
N:A[C>G]G	0.0
T:A[C>G]T	217.5
U:A[C>G]T	216.5
B:A[C>G]T	0.0
N:A[C>G]T	959.5
T:A[C>T]A	156.0
U:A[C>T]A	133.5
B:A[C>T]A	0.0
N:A[C>T]A	625.0
T:A[C>T]C	516.5
U:A[C>T]C	709.5
B:A[C>T]C	0.0
N:A[C>T]C	2603.0
T:A[C>T]G	190.5
U:A[C>T]G	185.5
B:A[C>T]G	0.0
N:A[C>T]G	699.5
T:A[C>T]T	587.0
U:A[C>T]T	629.5
B:A[C>T]T	1.5
N:A[C>T]T	2682.5
T:A[T>A]A	1708.5
U:A[T>A]A	1403.0
B:A[T>A]A	4.0
N:A[T>A]A	7246.5
T:A[T>A]C	344.5
U:A[T>A]C	298.0
B:A[T>A]C	0.5
N:A[T>A]C	1485.5
T:A[T>A]G	7.5
U:A[T>A]G	6.5
B:A[T>A]G	0.0
N:A[T>A]G	65.0
T:A[T>A]T	4772.5
U:A[T>A]T	5535.5
B:A[T>A]T	37.0
N:A[T>A]T	24279.0
T:A[T>C]A	21.5
U:A[T>C]A	16.5
B:A[T>C]A	0.0
N:A[T>C]A	116.5
T:A[T>C]C	30.5
U:A[T>C]C	20.5
B:A[T>C]C	0.0
N:A[T>C]C	153.5
T:A[T>C]G	68.5
U:A[T>C]G	62.5
B:A[T>C]G	0.0
N:A[T>C]G	312.5
T:A[T>C]T	169.0
U:A[T>C]T	182.5
B:A[T>C]T	0.0
N:A[T>C]T	826.5
T:A[T>G]A	1191.5
U:A[T>G]A	1098.0
B:A[T>G]A	1.5
N:A[T>G]A	5542.5
T:A[T>G]C	79.0
U:A[T>G]C	100.0
B:A[T>G]C	0.0
N:A[T>G]C	472.0
T:A[T>G]G	30.0
U:A[T>G]G	52.5
B:A[T>G]G	0.0
N:A[T>G]G	255.0
T:A[T>G]T	0.0
U:A[T>G]T	0.0
B:A[T>G]T	0.0
N:A[T>G]T	0.0
T:C[C>A]A	4.0
U:C[C>A]A	3.5
B:C[C>A]A	0.0
N:C[C>A]A	49.5
T:C[C>A]C	310.5
U:C[C>A]C	350.5
B:C[C>A]C	0.0
N:C[C>A]C	1385.5
T:C[C>A]G	210.0
U:C[C>A]G	285.5
B:C[C>A]G	0.0
N:C[C>A]G	949.5
T:C[C>A]T	1748.5
U:C[C>A]T	2166.0
B:C[C>A]T	8.5
N:C[C>A]T	8564.0
T:C[C>G]A	16.0
U:C[C>G]A	12.5
B:C[C>G]A	0.0
N:C[C>G]A	81.0
T:C[C>G]C	146.0
U:C[C>G]C	175.5
B:C[C>G]C	0.0
N:C[C>G]C	635.0
T:C[C>G]G	8.5
U:C[C>G]G	17.5
B:C[C>G]G	0.0
N:C[C>G]G	61.0
T:C[C>G]T	371.0
U:C[C>G]T	479.5
B:C[C>G]T	1.5
N:C[C>G]T	1728.0
T:C[C>T]A	176.5
U:C[C>T]A	241.5
B:C[C>T]A	0.0
N:C[C>T]A	1028.0
T:C[C>T]C	420.5
U:C[C>T]C	655.5
B:C[C>T]C	0.5
N:C[C>T]C	2177.5
T:C[C>T]G	647.0
U:C[C>T]G	1044.5
B:C[C>T]G	4.0
N:C[C>T]G	2700.5
T:C[C>T]T	1592.0
U:C[C>T]T	2194.0
B:C[C>T]T	11.0
N:C[C>T]T	7805.0
T:C[T>A]A	456.5
U:C[T>A]A	397.0
B:C[T>A]A	1.0
N:C[T>A]A	1687.5
T:C[T>A]C	1187.0
U:C[T>A]C	1460.5
B:C[T>A]C	9.0
N:C[T>A]C	5362.5
T:C[T>A]G	115.0
U:C[T>A]G	115.0
B:C[T>A]G	0.0
N:C[T>A]G	497.0
T:C[T>A]T	3508.5
U:C[T>A]T	4740.0
B:C[T>A]T	32.5
N:C[T>A]T	19646.5
T:C[T>C]A	758.5
U:C[T>C]A	816.0
B:C[T>C]A	3.5
N:C[T>C]A	3058.5
T:C[T>C]C	425.0
U:C[T>C]C	482.5
B:C[T>C]C	1.5
N:C[T>C]C	1637.0
T:C[T>C]G	239.5
U:C[T>C]G	281.0
B:C[T>C]G	0.0
N:C[T>C]G	900.0
T:C[T>C]T	3749.0
U:C[T>C]T	4787.0
B:C[T>C]T	34.0
N:C[T>C]T	18774.5
T:C[T>G]A	309.0
U:C[T>G]A	304.0
B:C[T>G]A	0.0
N:C[T>G]A	1308.5
T:C[T>G]C	495.5
U:C[T>G]C	602.0
B:C[T>G]C	2.5
N:C[T>G]C	2210.0
T:C[T>G]G	193.0
U:C[T>G]G	311.0
B:C[T>G]G	0.0
N:C[T>G]G	1076.5
T:C[T>G]T	1403.5
U:C[T>G]T	1893.5
B:C[T>G]T	10.0
N:C[T>G]T	7244.5
T:G[C>A]A	115.5
U:G[C>A]A	75.0
B:G[C>A]A	0.0
N:G[C>A]A	469.0
T:G[C>A]C	45.0
U:G[C>A]C	43.0
B:G[C>A]C	0.0
N:G[C>A]C	209.0
T:G[C>A]G	0.0
U:G[C>A]G	0.0
B:G[C>A]G	0.0
N:G[C>A]G	0.0
T:G[C>A]T	44.0
U:G[C>A]T	52.5
B:G[C>A]T	0.0
N:G[C>A]T	258.0
T:G[C>G]A	15.5
U:G[C>G]A	12.0
B:G[C>G]A	0.0
N:G[C>G]A	82.5
T:G[C>G]C	41.0
U:G[C>G]C	49.0
B:G[C>G]C	0.0
N:G[C>G]C	189.5
T:G[C>G]G	2.5
U:G[C>G]G	4.5
B:G[C>G]G	0.0
N:G[C>G]G	24.0
T:G[C>G]T	117.5
U:G[C>G]T	160.5
B:G[C>G]T	0.0
N:G[C>G]T	641.5
T:G[C>T]A	8.0
U:G[C>T]A	9.5
B:G[C>T]A	0.0
N:G[C>T]A	52.0
T:G[C>T]C	0.0
U:G[C>T]C	0.0
B:G[C>T]C	0.0
N:G[C>T]C	0.0
T:G[C>T]G	3.0
U:G[C>T]G	5.5
B:G[C>T]G	0.0
N:G[C>T]G	25.0
T:G[C>T]T	26.0
U:G[C>T]T	36.5
B:G[C>T]T	0.0
N:G[C>T]T	226.5
T:G[T>A]A	193.0
U:G[T>A]A	184.5
B:G[T>A]A	0.0
N:G[T>A]A	831.0
T:G[T>A]C	174.5
U:G[T>A]C	217.5
B:G[T>A]C	0.0
N:G[T>A]C	847.5
T:G[T>A]G	0.0
U:G[T>A]G	0.0
B:G[T>A]G	0.0
N:G[T>A]G	0.0
T:G[T>A]T	1472.5
U:G[T>A]T	2045.0
B:G[T>A]T	7.0
N:G[T>A]T	8215.5
T:G[T>C]A	0.0
U:G[T>C]A	0.0
B:G[T>C]A	0.0
N:G[T>C]A	0.0
T:G[T>C]C	35.0
U:G[T>C]C	35.5
B:G[T>C]C	0.0
N:G[T>C]C	167.5
T:G[T>C]G	13.0
U:G[T>C]G	14.0
B:G[T>C]G	0.0
N:G[T>C]G	70.5
T:G[T>C]T	392.5
U:G[T>C]T	695.5
B:G[T>C]T	1.0
N:G[T>C]T	2237.0
T:G[T>G]A	215.0
U:G[T>G]A	301.0
B:G[T>G]A	1.0
N:G[T>G]A	1013.5
T:G[T>G]C	142.5
U:G[T>G]C	202.5
B:G[T>G]C	0.5
N:G[T>G]C	747.5
T:G[T>G]G	621.0
U:G[T>G]G	1144.0
B:G[T>G]G	2.5
N:G[T>G]G	3081.5
T:G[T>G]T	741.5
U:G[T>G]T	1123.5
B:G[T>G]T	2.5
N:G[T>G]T	4210.0
T:T[C>A]A	294.5
U:T[C>A]A	252.0
B:T[C>A]A	0.0
N:T[C>A]A	1105.5
T:T[C>A]C	1459.5
U:T[C>A]C	1531.5
B:T[C>A]C	8.0
N:T[C>A]C	5443.0
T:T[C>A]G	0.0
U:T[C>A]G	0.0
B:T[C>A]G	0.0
N:T[C>A]G	0.0
T:T[C>A]T	535.5
U:T[C>A]T	659.0
B:T[C>A]T	0.5
N:T[C>A]T	2653.5
T:T[C>G]A	223.0
U:T[C>G]A	220.0
B:T[C>G]A	0.5
N:T[C>G]A	910.0
T:T[C>G]C	517.0
U:T[C>G]C	568.5
B:T[C>G]C	2.0
N:T[C>G]C	2107.0
T:T[C>G]G	0.0
U:T[C>G]G	0.0
B:T[C>G]G	0.0
N:T[C>G]G	0.0
T:T[C>G]T	1371.0
U:T[C>G]T	1829.5
B:T[C>G]T	7.5
N:T[C>G]T	6795.0
T:T[C>T]A	1153.0
U:T[C>T]A	1421.5
B:T[C>T]A	1.5
N:T[C>T]A	6854.0
T:T[C>T]C	950.0
U:T[C>T]C	1356.0
B:T[C>T]C	2.5
N:T[C>T]C	5645.5
T:T[C>T]G	0.0
U:T[C>T]G	0.0
B:T[C>T]G	0.0
N:T[C>T]G	3.0
T:T[C>T]T	141.0
U:T[C>T]T	206.0
B:T[C>T]T	0.0
N:T[C>T]T	970.5
T:T[T>A]A	1844.5
U:T[T>A]A	2128.0
B:T[T>A]A	12.5
N:T[T>A]A	7831.0
T:T[T>A]C	2300.5
U:T[T>A]C	2999.5
B:T[T>A]C	14.0
N:T[T>A]C	11772.0
T:T[T>A]G	862.5
U:T[T>A]G	1291.5
B:T[T>A]G	6.0
N:T[T>A]G	4452.0
T:T[T>A]T	17776.5
U:T[T>A]T	28049.0
B:T[T>A]T	205.5
N:T[T>A]T	111915.0
T:T[T>C]A	2276.5
U:T[T>C]A	2995.0
B:T[T>C]A	13.5
N:T[T>C]A	10952.0
T:T[T>C]C	1731.5
U:T[T>C]C	2286.5
B:T[T>C]C	12.5
N:T[T>C]C	8524.5
T:T[T>C]G	965.0
U:T[T>C]G	1401.0
B:T[T>C]G	4.5
N:T[T>C]G	4774.0
T:T[T>C]T	5895.0
U:T[T>C]T	8724.5
B:T[T>C]T	71.0
N:T[T>C]T	31514.5
T:T[T>G]A	1819.5
U:T[T>G]A	2419.5
B:T[T>G]A	12.5
N:T[T>G]A	9375.0
T:T[T>G]C	1245.0
U:T[T>G]C	1759.5
B:T[T>G]C	8.5
N:T[T>G]C	6858.0
T:T[T>G]G	914.5
U:T[T>G]G	1406.0
B:T[T>G]G	5.5
N:T[T>G]G	4899.0
T:T[T>G]T	3708.5
U:T[T>G]T	6014.5
B:T[T>G]T	40.5
N:T[T>G]T	21439.0

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Transcribed_real_count	UnTranscribed_real_count	NonTranscribed_real_count	Transcribed_mean_sims_count	UnTranscribed_mean_sims_count	NonTranscribed_mean_sims_count	transcribed_versus_untranscribed_p_value	transcribed_versus_untranscribed_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Transcribed_real_count.1	Transcribed_mean_sims_count.1	Transcribed_min_sims_count	Transcribed_max_sims_count	Transcribed_sims_count_list	UnTranscribed_real_count.1	UnTranscribed_mean_sims_count.1	UnTranscribed_min_sims_count	UnTranscribed_max_sims_count	UnTranscribed_sims_count_list	NonTranscribed_real_count.1	NonTranscribed_mean_sims_count.1	NonTranscribed_min_sims_count	NonTranscribed_max_sims_count	NonTranscribed_sims_count_list
Skin-Melanoma	SBS7c	C>A	2489.0	3333.0	12338.0	4002.82	4094.91	10122.28	6.824957927633781e-15	5.0443982694695456e-14	2.187	830185.0	Untranscribed	1.339	1.023	1.309	1	1	1				2489.0	4002.82	3886.0	4124.0	[4016, 3917, 4019, 3985, 4095, 4068, 3952, 4109, 4006, 3916, 4113, 4006, 4036, 4038, 3917, 4007, 4058, 4020, 3998, 4006, 4015, 3988, 4025, 3941, 3924, 3985, 4028, 4075, 3956, 4060, 3922, 4024, 3946, 4089, 3908, 3994, 3990, 3961, 4011, 3979, 3950, 3886, 4124, 3990, 3983, 3973, 3999, 4026, 4104, 4083, 3971, 3967, 4031, 3938, 3985, 3902, 4019, 3935, 4076, 4007, 3901, 4035, 4043, 4066, 3898, 4023, 3996, 4040, 3940, 4102, 3968, 3965, 4071, 4084, 4056, 3909, 4019, 4000, 3950, 3970, 3969, 4002, 3994, 3919, 3993, 4057, 3975, 4069, 4107, 3963, 4013, 3953, 3975, 4059, 4079, 4017, 4023, 4001, 4028, 3998]	3333.0	4094.91	3952.0	4236.0	[4010, 4144, 4081, 4036, 4096, 4075, 4129, 4019, 4114, 4169, 4116, 4176, 4067, 4156, 4205, 4070, 4184, 4141, 4018, 4151, 4154, 4078, 4077, 4102, 4095, 4115, 4030, 4119, 4140, 4038, 4218, 4235, 4073, 4165, 4085, 3952, 4084, 4078, 4093, 4032, 4101, 4097, 4085, 4119, 4134, 4129, 4077, 4066, 4097, 4133, 4078, 4164, 4093, 4152, 4048, 4120, 4123, 4041, 4110, 4146, 4153, 4078, 3972, 3992, 4080, 4147, 4122, 4098, 4236, 4012, 4096, 4069, 4141, 4065, 3983, 4136, 4018, 4152, 4105, 4056, 4153, 4130, 4004, 4098, 4028, 4057, 4047, 4016, 3991, 4169, 4040, 4094, 4181, 4060, 4151, 4063, 4090, 4010, 4116, 4049]	12338.0	10122.28	9970.0	10273.0	[10191, 10167, 10115, 10211, 10030, 10079, 10152, 10083, 10093, 10134, 9992, 10037, 10131, 10030, 10111, 10139, 9994, 10066, 10202, 10072, 10028, 10148, 10129, 10176, 10190, 10124, 10157, 10023, 10125, 10109, 10074, 9972, 10200, 9970, 10214, 10273, 10141, 10187, 10123, 10218, 10173, 10224, 10004, 10105, 10103, 10131, 10156, 10107, 10004, 9999, 10160, 10095, 10078, 10126, 10191, 10205, 10087, 10247, 10038, 10085, 10166, 10117, 10192, 10170, 10247, 10054, 10091, 10079, 10043, 10111, 10159, 10180, 10025, 10072, 10188, 10158, 10174, 10063, 10161, 10192, 10107, 10089, 10207, 10208, 10204, 10109, 10198, 10137, 10129, 10095, 10178, 10178, 10057, 10107, 9991, 10148, 10118, 10185, 10061, 10152]
Skin-Melanoma	SBS7c	C>G	1998.0	2758.0	10062.0	3023.79	3253.88	8567.92	1.2800617640248155e-10	8.126953929912607e-10	1.785	830185.0	Untranscribed	1.38	1.076	1.283	1	1					1998.0	3023.79	2865.0	3156.0	[2973, 3001, 3014, 2988, 2993, 3044, 2985, 3021, 3015, 3055, 3029, 3015, 2984, 2977, 3008, 3049, 2973, 3091, 2961, 2997, 3080, 3067, 3021, 3053, 3035, 3003, 3102, 2942, 2976, 3005, 2982, 3017, 2965, 3041, 2966, 3060, 3008, 2907, 3069, 3123, 2924, 3113, 3020, 3059, 2931, 3012, 3099, 3030, 3060, 3075, 3046, 3029, 3032, 2968, 3022, 2880, 3068, 3028, 3067, 3051, 3057, 3022, 2957, 2978, 2942, 3070, 3078, 3091, 3050, 3052, 3135, 2975, 3012, 3001, 3023, 3073, 2997, 3122, 3042, 3061, 2957, 2987, 3080, 2985, 2984, 3066, 3156, 3068, 3007, 3041, 2949, 2865, 3045, 3117, 3047, 3013, 3046, 3029, 3013, 3077]	2758.0	3253.88	3118.0	3384.0	[3311, 3277, 3304, 3230, 3236, 3309, 3248, 3293, 3297, 3238, 3304, 3302, 3279, 3328, 3295, 3313, 3200, 3196, 3176, 3137, 3208, 3248, 3252, 3157, 3298, 3192, 3239, 3359, 3265, 3278, 3232, 3258, 3350, 3291, 3266, 3242, 3333, 3308, 3218, 3319, 3248, 3178, 3248, 3240, 3354, 3159, 3189, 3264, 3222, 3231, 3183, 3271, 3280, 3217, 3283, 3299, 3277, 3304, 3211, 3182, 3295, 3209, 3242, 3263, 3268, 3290, 3198, 3271, 3255, 3177, 3273, 3240, 3211, 3304, 3265, 3254, 3258, 3232, 3249, 3224, 3274, 3299, 3271, 3223, 3333, 3240, 3261, 3257, 3221, 3222, 3287, 3384, 3223, 3231, 3219, 3265, 3237, 3239, 3180, 3118]	10062.0	8567.92	8408.0	8716.0	[8569, 8557, 8523, 8627, 8618, 8495, 8623, 8528, 8525, 8552, 8521, 8519, 8581, 8529, 8526, 8478, 8668, 8564, 8713, 8716, 8572, 8534, 8578, 8641, 8511, 8643, 8509, 8535, 8606, 8568, 8623, 8561, 8513, 8512, 8612, 8536, 8511, 8640, 8558, 8408, 8678, 8560, 8579, 8558, 8555, 8662, 8569, 8559, 8576, 8530, 8599, 8545, 8541, 8671, 8541, 8664, 8495, 8520, 8567, 8624, 8495, 8610, 8643, 8608, 8655, 8476, 8564, 8489, 8532, 8619, 8445, 8631, 8618, 8544, 8546, 8520, 8601, 8490, 8556, 8568, 8606, 8570, 8504, 8632, 8533, 8534, 8447, 8515, 8629, 8577, 8608, 8595, 8569, 8505, 8576, 8553, 8569, 8578, 8645, 8641]
Skin-Melanoma	SBS7c	C>T	0.0	0.0	0.0	0.0	0.0	0.0	1.0	1.0	0.0	830185.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Skin-Melanoma	SBS7c	T>A	63636.0	94584.0	371621.0	100517.09	122485.5	308205.67	7.324441090578729e-196	1.9160534436256995e-194	63.822	830185.0	Untranscribed	1.486	1.219	1.22	1	1					63636.0	100517.09	99924.0	101297.0	[100721, 99924, 100323, 100723, 100486, 100377, 100400, 100212, 100935, 100116, 100512, 100267, 100290, 100388, 100229, 100515, 100742, 100610, 100561, 100248, 100069, 100562, 100340, 100173, 100601, 100473, 101087, 100583, 100957, 100256, 100438, 100704, 100487, 100356, 100360, 100902, 100178, 100929, 100887, 100339, 100243, 100287, 100679, 100737, 100723, 100190, 100644, 100835, 100514, 100249, 100430, 100126, 100857, 100414, 100601, 100563, 100800, 100022, 100520, 100342, 100556, 101016, 100142, 100639, 100940, 100220, 101297, 100606, 100420, 100635, 100631, 100716, 100126, 100468, 100803, 101025, 100230, 101158, 100555, 100346, 100159, 100300, 100602, 100431, 100317, 100556, 100443, 100642, 100642, 100752, 100144, 100842, 100624, 100533, 100871, 100600, 100896, 99973, 100501, 100316]	94584.0	122485.5	121660.0	123321.0	[122725, 122169, 123083, 122526, 122478, 122532, 122408, 122435, 122394, 122179, 122370, 122552, 122495, 122530, 122361, 122474, 122371, 122576, 122803, 122446, 122373, 122339, 122777, 122188, 122712, 122376, 122672, 122243, 122288, 122380, 122470, 122530, 122086, 122022, 122797, 122652, 122544, 122499, 122367, 122398, 122253, 123128, 122477, 122081, 123150, 122971, 122873, 122228, 122304, 122847, 122142, 122254, 122712, 122509, 121660, 122478, 122219, 122555, 122611, 122856, 122267, 122302, 122879, 122060, 122216, 122279, 122341, 122671, 122174, 122818, 122253, 122568, 122206, 122286, 122388, 123321, 122265, 122316, 122576, 122472, 122675, 122581, 122297, 122271, 122600, 123020, 122524, 122811, 122755, 122659, 122526, 121980, 122502, 122434, 122413, 122197, 122685, 123008, 122304, 122722]	371621.0	308205.67	306860.0	309100.0	[307798, 309100, 307860, 307945, 308246, 308316, 308399, 308577, 307869, 308932, 308394, 308361, 308449, 308267, 308608, 308153, 308120, 308033, 307908, 308528, 308746, 308313, 308039, 308852, 307941, 308421, 307436, 308336, 307974, 308602, 308300, 307945, 308654, 308835, 308025, 307724, 308538, 307769, 307958, 308402, 308732, 307812, 308021, 308383, 307357, 308144, 307713, 308121, 308448, 308104, 308595, 308772, 307644, 308199, 309011, 308122, 308274, 308647, 308074, 308013, 308322, 307907, 308158, 308497, 308021, 308687, 307653, 307902, 308519, 307736, 308384, 307983, 308886, 308406, 308039, 306860, 308732, 307707, 308102, 308404, 308372, 308355, 308298, 308434, 308276, 307621, 308184, 307663, 307771, 307806, 308522, 308396, 308083, 308320, 307898, 308398, 307651, 308240, 308312, 308203]
Skin-Melanoma	SBS7c	T>C	14759.0	21529.0	78981.0	21589.89	26826.47	67084.61	3.8590939080114396e-30	3.8424335025935925e-29	13.885	830185.0	Untranscribed	1.459	1.243	1.174	1						14759.0	21589.89	21243.0	21921.0	[21384, 21635, 21904, 21277, 21718, 21529, 21511, 21726, 21793, 21449, 21567, 21747, 21243, 21921, 21492, 21636, 21445, 21696, 21504, 21751, 21714, 21812, 21867, 21345, 21606, 21607, 21555, 21578, 21705, 21572, 21642, 21705, 21575, 21686, 21660, 21615, 21609, 21467, 21464, 21752, 21538, 21758, 21544, 21363, 21732, 21484, 21444, 21763, 21408, 21733, 21693, 21479, 21444, 21619, 21481, 21475, 21552, 21477, 21844, 21587, 21501, 21608, 21565, 21746, 21503, 21567, 21604, 21626, 21511, 21512, 21668, 21590, 21478, 21854, 21751, 21427, 21698, 21522, 21549, 21661, 21549, 21469, 21617, 21554, 21569, 21527, 21503, 21561, 21617, 21408, 21575, 21658, 21562, 21564, 21551, 21651, 21254, 21462, 21671, 21844]	21529.0	26826.47	26377.0	27200.0	[26953, 26785, 26851, 26935, 26860, 26674, 26805, 26871, 26727, 26833, 27028, 26887, 27200, 26654, 26744, 26797, 26878, 26765, 26809, 26825, 26679, 26895, 26662, 26825, 26711, 26923, 26377, 26822, 26804, 26712, 26903, 26864, 26963, 26662, 26694, 26819, 27077, 27097, 26822, 26676, 27086, 26704, 26823, 26574, 26841, 26955, 26803, 26864, 26730, 26682, 26746, 26674, 26707, 26839, 26726, 26783, 26950, 26883, 26882, 26745, 26754, 26978, 26957, 26585, 26550, 26703, 26583, 26777, 26785, 27050, 26992, 26909, 26851, 27002, 26806, 26735, 26804, 26911, 26901, 26850, 26797, 27042, 26727, 26809, 26987, 26737, 26853, 26663, 26930, 27044, 26806, 27023, 26985, 26752, 27051, 26908, 26873, 26760, 26866, 26686]	78981.0	67084.61	66665.0	67549.0	[67140, 67074, 66740, 67307, 66916, 67290, 67186, 66894, 66976, 67196, 66896, 66897, 67103, 66946, 67238, 67068, 67160, 67057, 67171, 66919, 67060, 66791, 67015, 67336, 67136, 66975, 67549, 67099, 67000, 67190, 66940, 66935, 66965, 67155, 67144, 67053, 66784, 66925, 67208, 67079, 66895, 67046, 67136, 67510, 66912, 67052, 67268, 66861, 67330, 67068, 67069, 67342, 67359, 67060, 67285, 67260, 67029, 67147, 66781, 67164, 67276, 66918, 66967, 67153, 67411, 67224, 67323, 67136, 67215, 66936, 66837, 66980, 67194, 66665, 66948, 67329, 66989, 67095, 67077, 67006, 67164, 67028, 67164, 67134, 66958, 67262, 67143, 67274, 67003, 67014, 67129, 66856, 66959, 67157, 66916, 66950, 67387, 67268, 66988, 66941]
Skin-Melanoma	SBS7c	T>G	19723.0	27935.0	104439.0	29629.98	34206.51	88598.7	6.915495668705906e-63	9.720400068662368e-62	18.321	830185.0	Untranscribed	1.416	1.154	1.227	1	1					19723.0	29629.98	29281.0	30097.0	[29749, 29468, 29789, 29817, 29367, 29713, 29604, 29712, 29816, 29537, 29575, 29615, 29560, 29634, 29736, 29508, 29584, 29454, 29609, 29576, 29754, 29717, 29575, 29710, 29465, 29879, 29844, 29542, 29285, 29627, 29771, 29639, 29617, 29458, 29737, 29830, 29726, 30097, 29550, 29541, 29700, 29281, 29697, 29735, 29911, 29645, 29418, 29398, 29593, 29445, 29630, 29535, 29697, 29762, 29657, 29502, 29720, 29759, 29696, 29728, 29649, 29891, 29418, 29314, 29440, 29523, 29500, 29440, 29764, 29622, 29550, 29727, 29710, 29589, 29648, 29563, 29805, 29516, 29443, 29755, 29679, 29724, 29876, 29568, 29691, 29579, 29664, 29667, 29632, 29815, 29496, 29761, 29517, 29548, 29521, 29590, 29433, 29607, 29929, 29538]	27935.0	34206.51	33858.0	34596.0	[34287, 34180, 34277, 34107, 34224, 34106, 34291, 34259, 34299, 34596, 34159, 34372, 34446, 34054, 34421, 34108, 34345, 34067, 34062, 34260, 34207, 34027, 34226, 33881, 34115, 34023, 33925, 33979, 34119, 34266, 33858, 34204, 34278, 34089, 34199, 34243, 34385, 34108, 34194, 34280, 34191, 34303, 34144, 34294, 34429, 34530, 34199, 34270, 34032, 34354, 33937, 34179, 34130, 34091, 34147, 34385, 34253, 34256, 34058, 34096, 33996, 34353, 34203, 34343, 34125, 34375, 34201, 34220, 33959, 34367, 34206, 34134, 34271, 34142, 34171, 34542, 34351, 34116, 34144, 34141, 34102, 34028, 34248, 34055, 33943, 34230, 34404, 34313, 34262, 34205, 34414, 34254, 34413, 34463, 33975, 34410, 34135, 34142, 34233, 34258]	104439.0	88598.7	88120.0	89059.0	[88434, 88816, 88327, 88474, 88827, 88621, 88594, 88506, 88299, 88331, 88689, 88426, 88417, 88716, 88246, 88852, 88485, 88926, 88786, 88619, 88466, 88663, 88660, 88818, 88860, 88507, 88675, 88888, 89059, 88500, 88773, 88643, 88535, 88867, 88499, 88377, 88356, 88220, 88731, 88617, 88565, 88859, 88559, 88424, 88120, 88242, 88796, 88708, 88809, 88639, 88816, 88724, 88616, 88587, 88593, 88593, 88462, 88402, 88674, 88622, 88773, 88235, 88786, 88838, 88861, 88563, 88713, 88768, 88703, 88460, 88663, 88608, 88485, 88694, 88607, 88291, 88266, 88812, 88871, 88552, 88684, 88653, 88331, 88813, 88783, 88601, 88389, 88412, 88507, 88430, 88538, 88424, 88475, 88431, 88933, 88489, 88899, 88666, 88293, 88655]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS7c	T>A	Untranscribed	['Skin-Melanoma']	1	['Skin-Melanoma']	1	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1	1.2
SBS7c	T>C	Untranscribed	['Skin-Melanoma']	1	[]	0	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1	1.1
SBS7c	T>G	Untranscribed	['Skin-Melanoma']	1	['Skin-Melanoma']	1	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1	1.2