# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	3357.942
E:A[C>A]A	3534.121
A:A[C>G]A	1069.379
E:A[C>G]A	1112.225
A:A[C>T]A	913.777
E:A[C>T]A	961.791
A:A[T>A]A	9239.529
E:A[T>A]A	9494.671
A:A[T>C]A	212.727
E:A[T>C]A	217.981
A:A[T>G]A	7080.827
E:A[T>G]A	7203.03
A:A[C>A]C	804.065
E:A[C>A]C	822.019
A:A[C>G]C	227.333
E:A[C>G]C	238.328
A:A[C>T]C	3515.959
E:A[C>T]C	3656.571
A:A[T>A]C	2017.492
E:A[T>A]C	2062.03
A:A[T>C]C	269.184
E:A[T>C]C	275.07
A:A[T>G]C	692.715
E:A[T>G]C	708.561
A:A[C>A]G	165.879
E:A[C>A]G	165.197
A:A[C>G]G	0.0
E:A[C>G]G	0.0
A:A[C>T]G	1077.797
E:A[C>T]G	1089.863
A:A[T>A]G	135.41
E:A[T>A]G	136.577
A:A[T>C]G	496.374
E:A[T>C]G	487.633
A:A[T>G]G	407.501
E:A[T>G]G	404.389
A:A[C>A]T	1160.338
E:A[C>A]T	1191.167
A:A[C>G]T	1408.782
E:A[C>G]T	1406.222
A:A[C>T]T	3643.016
E:A[C>T]T	3667.564
A:A[T>A]T	31347.627
E:A[T>A]T	30890.4
A:A[T>C]T	1185.931
E:A[T>C]T	1173.66
A:A[T>G]T	0.0
E:A[T>G]T	0.0
A:C[C>A]A	115.099
E:C[C>A]A	120.269
A:C[C>G]A	153.651
E:C[C>G]A	164.088
A:C[C>T]A	1408.053
E:C[C>T]A	1457.122
A:C[T>A]A	2411.618
E:C[T>A]A	2445.363
A:C[T>C]A	4305.118
E:C[T>C]A	4353.175
A:C[T>G]A	1869.116
E:C[T>G]A	1854.471
A:C[C>A]C	1967.969
E:C[C>A]C	2034.407
A:C[C>G]C	968.554
E:C[C>G]C	989.358
A:C[C>T]C	3078.153
E:C[C>T]C	3127.141
A:C[T>A]C	7431.356
E:C[T>A]C	7397.827
A:C[T>C]C	2451.049
E:C[T>C]C	2420.395
A:C[T>G]C	3077.934
E:C[T>G]C	3131.927
A:C[C>A]G	1403.364
E:C[C>A]G	1451.041
A:C[C>G]G	155.918
E:C[C>G]G	150.804
A:C[C>T]G	4117.491
E:C[C>T]G	4134.731
A:C[T>A]G	781.994
E:C[T>A]G	759.268
A:C[T>C]G	1414.089
E:C[T>C]G	1378.702
A:C[T>G]G	1599.573
E:C[T>G]G	1523.914
A:C[C>A]T	11651.947
E:C[C>A]T	11318.014
A:C[C>G]T	2488.445
E:C[C>G]T	2413.926
A:C[C>T]T	10770.554
E:C[C>T]T	10578.657
A:C[T>A]T	25844.108
E:C[T>A]T	24785.499
A:C[T>C]T	25128.819
E:C[T>C]T	24329.622
A:C[T>G]T	9899.123
E:C[T>G]T	9370.132
A:G[C>A]A	678.431
E:G[C>A]A	717.34
A:G[C>G]A	161.245
E:G[C>G]A	167.831
A:G[C>T]A	118.908
E:G[C>T]A	124.33
A:G[T>A]A	1205.809
E:G[T>A]A	1208.419
A:G[T>C]A	0.0
E:G[T>C]A	0.0
A:G[T>G]A	1490.497
E:G[T>G]A	1507.4
A:G[C>A]C	358.218
E:G[C>A]C	360.181
A:G[C>G]C	352.765
E:G[C>G]C	347.481
A:G[C>T]C	4.259
E:G[C>T]C	4.279
A:G[T>A]C	1240.781
E:G[T>A]C	1235.767
A:G[T>C]C	309.938
E:G[T>C]C	302.407
A:G[T>G]C	1137.458
E:G[T>G]C	1093.356
A:G[C>A]G	0.0
E:G[C>A]G	0.0
A:G[C>G]G	87.934
E:G[C>G]G	88.218
A:G[C>T]G	64.082
E:G[C>T]G	63.55
A:G[T>A]G	0.0
E:G[T>A]G	0.0
A:G[T>C]G	158.739
E:G[T>C]G	152.014
A:G[T>G]G	4686.048
E:G[T>G]G	4408.034
A:G[C>A]T	419.134
E:G[C>A]T	397.622
A:G[C>G]T	949.105
E:G[C>G]T	926.715
A:G[C>T]T	360.335
E:G[C>T]T	350.084
A:G[T>A]T	10908.411
E:G[T>A]T	10447.218
A:G[T>C]T	3192.046
E:G[T>C]T	3057.224
A:G[T>G]T	5707.167
E:G[T>G]T	5522.725
A:T[C>A]A	1611.379
E:T[C>A]A	1616.058
A:T[C>G]A	1363.056
E:T[C>G]A	1377.472
A:T[C>T]A	8571.093
E:T[C>T]A	8690.174
A:T[T>A]A	10845.845
E:T[T>A]A	10617.871
A:T[T>C]A	14817.424
E:T[T>C]A	14546.624
A:T[T>G]A	12452.918
E:T[T>G]A	12297.189
A:T[C>A]C	7732.384
E:T[C>A]C	7805.63
A:T[C>G]C	3036.95
E:T[C>G]C	3063.84
A:T[C>T]C	7337.984
E:T[C>T]C	7321.824
A:T[T>A]C	15679.524
E:T[T>A]C	15284.457
A:T[T>C]C	11638.389
E:T[T>C]C	11309.056
A:T[T>G]C	9205.804
E:T[T>G]C	8883.976
A:T[C>A]G	0.0
E:T[C>A]G	0.0
A:T[C>G]G	6.403
E:T[C>G]G	6.601
A:T[C>T]G	22.582
E:T[C>T]G	22.406
A:T[T>A]G	6217.528
E:T[T>A]G	5976.267
A:T[T>C]G	6702.517
E:T[T>C]G	6419.795
A:T[T>G]G	6829.848
E:T[T>G]G	6502.67
A:T[C>A]T	3630.783
E:T[C>A]T	3527.407
A:T[C>G]T	9418.855
E:T[C>G]T	9012.339
A:T[C>T]T	1341.258
E:T[C>T]T	1297.531
A:T[T>A]T	146126.469
E:T[T>A]T	138278.315
A:T[T>C]T	42840.333
E:T[T>C]T	40365.278
A:T[T>G]T	29203.292
E:T[T>G]T	27423.562

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
Skin-Melanoma	SBS7c	C>A	8265.0	7983.0	8175.83	8132.08	0.18712305450094124	0.47045108763406834	2.2	738393.0	Lagging	1.035	1.005	1.03							8265.0	8175.83	8017.0	8341.0	[8235, 8167, 8062, 8127, 8148, 8187, 8218, 8118, 8159, 8120, 8153, 8096, 8199, 8135, 8168, 8218, 8152, 8143, 8087, 8283, 8260, 8030, 8213, 8178, 8193, 8144, 8093, 8244, 8158, 8129, 8183, 8341, 8213, 8112, 8190, 8198, 8251, 8151, 8019, 8131, 8153, 8200, 8145, 8223, 8217, 8210, 8195, 8269, 8077, 8178, 8129, 8336, 8101, 8213, 8271, 8212, 8034, 8187, 8127, 8172, 8200, 8163, 8157, 8182, 8295, 8224, 8140, 8237, 8175, 8134, 8215, 8115, 8017, 8092, 8210, 8151, 8299, 8142, 8235, 8170, 8227, 8150, 8253, 8075, 8180, 8241, 8184, 8253, 8182, 8154, 8135, 8227, 8224, 8186, 8212, 8162, 8156, 8210, 8145, 8219]	7983.0	8132.08	7967.0	8314.0	[8098, 8194, 8297, 8184, 8123, 8146, 8097, 8193, 8115, 8206, 8195, 8197, 8055, 8108, 8147, 8128, 8154, 8184, 8187, 7994, 8050, 8314, 8128, 8153, 8046, 8189, 8184, 8044, 8141, 8198, 8155, 7967, 8025, 8164, 8117, 8072, 8025, 8118, 8272, 8178, 8178, 8151, 8112, 8085, 8173, 8079, 8075, 8006, 8256, 8151, 8255, 8043, 8186, 8058, 8061, 8121, 8235, 8166, 8209, 8119, 8128, 8129, 8143, 8121, 7990, 8068, 8169, 8054, 8018, 8122, 8074, 8196, 8270, 8212, 8086, 8124, 8054, 8115, 8096, 8124, 8133, 8151, 8087, 8226, 8154, 8109, 8094, 8113, 8124, 8136, 8196, 8083, 8131, 8086, 8129, 8133, 8156, 8164, 8164, 8085]
Skin-Melanoma	SBS7c	C>G	6769.0	6463.0	6727.37	6553.03	0.4174806428085572	0.8371105271430942	1.792	738393.0	Lagging	1.047	1.027	1.02							6769.0	6727.37	6595.0	6929.0	[6675, 6804, 6813, 6773, 6719, 6771, 6714, 6720, 6649, 6688, 6680, 6833, 6752, 6709, 6675, 6740, 6685, 6687, 6701, 6764, 6707, 6755, 6703, 6782, 6744, 6773, 6759, 6703, 6705, 6723, 6732, 6703, 6865, 6873, 6775, 6725, 6725, 6660, 6777, 6830, 6773, 6677, 6834, 6741, 6683, 6701, 6722, 6768, 6685, 6728, 6755, 6626, 6807, 6752, 6608, 6715, 6742, 6767, 6746, 6692, 6762, 6595, 6929, 6673, 6620, 6660, 6604, 6728, 6675, 6681, 6716, 6739, 6742, 6664, 6872, 6720, 6677, 6754, 6787, 6643, 6714, 6644, 6695, 6697, 6679, 6805, 6726, 6699, 6740, 6717, 6610, 6821, 6681, 6799, 6750, 6696, 6670, 6621, 6789, 6850]	6463.0	6553.03	6385.0	6704.0	[6582, 6468, 6484, 6487, 6619, 6521, 6575, 6540, 6603, 6551, 6526, 6444, 6510, 6560, 6619, 6594, 6609, 6582, 6590, 6513, 6537, 6473, 6563, 6517, 6555, 6474, 6554, 6583, 6518, 6582, 6593, 6569, 6432, 6437, 6501, 6515, 6545, 6552, 6495, 6449, 6502, 6580, 6434, 6529, 6599, 6543, 6500, 6557, 6618, 6610, 6563, 6645, 6471, 6519, 6632, 6527, 6541, 6526, 6543, 6531, 6586, 6660, 6385, 6622, 6693, 6623, 6704, 6538, 6661, 6682, 6562, 6517, 6499, 6676, 6468, 6581, 6571, 6530, 6540, 6624, 6599, 6642, 6618, 6547, 6651, 6412, 6522, 6599, 6630, 6526, 6664, 6474, 6632, 6504, 6455, 6534, 6590, 6659, 6466, 6466]
Skin-Melanoma	SBS7c	C>T	0.0	0.0	0.0	0.0	1.0	1.0	0.0	738393.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Skin-Melanoma	SBS7c	T>A	243724.0	227557.0	242510.77	232093.7	1.8641750013981624e-09	1.1314200693233423e-08	63.825	738393.0	Lagging	1.071	1.045	1.025							243724.0	242510.77	241615.0	243319.0	[242796, 242635, 242351, 242235, 242356, 242454, 242377, 242143, 242232, 242393, 243001, 242611, 242362, 242954, 242307, 242977, 243122, 242508, 243201, 242300, 241615, 242682, 242227, 242827, 241935, 242537, 242372, 242677, 242648, 242200, 241847, 242551, 242513, 242561, 242796, 242700, 242448, 243154, 242166, 242817, 242977, 242814, 242816, 242304, 242197, 241873, 242372, 242779, 242540, 242187, 242603, 242222, 243238, 242989, 242080, 242799, 242552, 242421, 242784, 242610, 241830, 242982, 241876, 242026, 242373, 242829, 242566, 242212, 242648, 242576, 242332, 242750, 242749, 241998, 242903, 242622, 242480, 242835, 241848, 242100, 242586, 243226, 242159, 241948, 242793, 242351, 242582, 242532, 242424, 242140, 243025, 243319, 242753, 242736, 242275, 242558, 242297, 242435, 242710, 241948]	227557.0	232093.7	231059.0	233084.0	[232094, 232221, 232488, 232399, 232234, 232307, 231844, 232086, 232288, 232315, 232171, 232416, 232186, 231703, 232175, 231608, 231635, 231777, 231495, 232091, 232820, 232006, 232238, 231619, 232599, 231938, 232040, 232006, 231709, 232293, 232503, 232040, 232288, 232038, 231818, 231719, 232620, 231391, 232565, 232295, 231987, 231942, 231937, 232350, 232554, 232400, 232180, 232273, 232075, 232481, 231706, 232017, 231822, 231544, 232661, 231605, 231838, 231963, 231868, 232354, 232768, 231768, 232472, 232428, 231931, 231714, 231786, 232208, 232022, 232424, 232357, 231891, 231750, 232538, 231681, 232125, 231841, 231749, 233084, 232243, 232255, 231571, 232188, 232407, 231755, 232225, 232446, 232034, 232073, 232163, 231860, 231059, 231558, 232438, 231962, 231992, 232340, 232173, 231957, 232499]
Skin-Melanoma	SBS7c	T>C	53050.0	49346.0	52785.92	50308.63	0.00596053139796849	0.02239360549482776	13.867	738393.0	Lagging	1.075	1.049	1.025							53050.0	52785.92	52331.0	53317.0	[53126, 53110, 52711, 52768, 52857, 52680, 52939, 52917, 52886, 52745, 52602, 52525, 52836, 52996, 52672, 52614, 52520, 52927, 52739, 53081, 52900, 52709, 52612, 52617, 52768, 52856, 52749, 52690, 52578, 52800, 52621, 52811, 53028, 52799, 52833, 52869, 53029, 52806, 52688, 52591, 52568, 52937, 52920, 52886, 52786, 52699, 52653, 52848, 53043, 52817, 52733, 52801, 52847, 52625, 52448, 52728, 52933, 52701, 52810, 53184, 52684, 52863, 52805, 52726, 52674, 52632, 53024, 52856, 53098, 52910, 52703, 52668, 52866, 53039, 52727, 52886, 52438, 52552, 52655, 53317, 52745, 52575, 52651, 52463, 52895, 52875, 52815, 52810, 52660, 53010, 52908, 52807, 52746, 52672, 52705, 52731, 52331, 52837, 53174, 52487]	49346.0	50308.63	49828.0	50844.0	[50028, 50137, 50566, 50301, 50270, 50362, 50168, 50156, 50259, 50179, 50524, 50531, 50445, 50150, 50466, 50485, 50612, 50199, 50417, 49828, 50006, 50341, 50205, 50378, 50295, 50231, 50181, 50205, 50343, 50223, 50296, 50235, 50302, 50418, 50209, 50267, 49934, 50150, 50300, 50545, 50501, 50103, 50276, 50459, 50400, 50241, 50494, 50220, 50113, 50291, 50417, 50322, 50068, 50565, 50512, 50364, 50061, 50306, 50287, 50031, 50297, 50400, 50340, 50637, 50442, 50584, 50153, 50207, 50015, 50275, 50299, 50400, 50237, 50010, 50383, 50207, 50669, 50574, 50423, 49974, 50342, 50496, 50431, 50718, 50334, 50121, 50157, 50210, 50539, 50058, 50259, 50365, 50411, 50470, 50382, 50337, 50844, 50222, 49921, 50542]
Skin-Melanoma	SBS7c	T>G	69604.0	65632.0	69169.83	66973.77	0.0005636551672667091	0.0023857179944872958	18.315	738393.0	Lagging	1.061	1.033	1.027							69604.0	69169.83	68733.0	69818.0	[69169, 68762, 69241, 68893, 69072, 69264, 69230, 68955, 69139, 69041, 69326, 69171, 69077, 69249, 69285, 69044, 69184, 69014, 69041, 69589, 69145, 68733, 69487, 69225, 69656, 69334, 68846, 69003, 68997, 68895, 69460, 69126, 69084, 68844, 68914, 68982, 69263, 69048, 69239, 69153, 69280, 69194, 68945, 69228, 68806, 69173, 69128, 69285, 69047, 68952, 69422, 69353, 69209, 69006, 69285, 69355, 68868, 69242, 69818, 69303, 69383, 69410, 69061, 69386, 69480, 69353, 69074, 68943, 69312, 69169, 69137, 69120, 69307, 68933, 69056, 69340, 69269, 69368, 69208, 69074, 69366, 69248, 69057, 69057, 69366, 68888, 69575, 68848, 69162, 69128, 69299, 69001, 69185, 69150, 69182, 69165, 69416, 69177, 69042, 69209]	65632.0	66973.77	66405.0	67450.0	[66988, 67273, 67022, 67284, 67050, 66660, 67073, 67002, 66892, 66934, 66876, 66965, 66998, 66894, 66715, 67009, 67049, 67187, 67072, 66546, 66877, 67450, 66830, 67144, 66604, 66793, 67257, 67242, 67103, 67184, 66639, 67030, 67135, 67097, 67296, 67270, 66917, 66950, 66683, 67139, 66934, 66714, 67154, 66984, 67263, 67198, 67132, 66890, 66930, 67056, 66777, 66828, 66978, 67284, 66947, 66827, 67138, 66928, 66405, 66780, 66910, 66610, 66926, 66827, 66729, 66712, 66934, 67121, 67117, 66931, 67045, 67203, 66659, 67217, 67025, 66941, 66894, 66723, 67153, 66993, 66868, 66868, 66850, 67019, 66897, 67178, 66717, 67338, 67001, 66718, 66961, 67231, 66836, 66993, 66944, 67012, 66747, 67060, 67015, 67178]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS7c	T>A	Lagging	[]	0	[]	0	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1	
SBS7c	T>C	Lagging	[]	0	[]	0	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1	
SBS7c	T>G	Lagging	[]	0	[]	0	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1