# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on transcribed:T, untranscribed:U, bitranscribed:B and nontranscribed:N strands averaged across cancer types. MutationType Across_All_Cancer_Types T:A[C>A]A 170.25 U:A[C>A]A 103.5 B:A[C>A]A 0.25 N:A[C>A]A 452.0 T:A[C>A]C 12.75 U:A[C>A]C 6.0 B:A[C>A]C 0.0 N:A[C>A]C 48.75 T:A[C>A]G 0.75 U:A[C>A]G 0.0 B:A[C>A]G 0.0 N:A[C>A]G 5.0 T:A[C>A]T 5.25 U:A[C>A]T 4.75 B:A[C>A]T 0.0 N:A[C>A]T 41.0 T:A[C>G]A 33.25 U:A[C>G]A 23.25 B:A[C>G]A 0.0 N:A[C>G]A 142.25 T:A[C>G]C 1.5 U:A[C>G]C 1.0 B:A[C>G]C 0.0 N:A[C>G]C 8.75 T:A[C>G]G 1.25 U:A[C>G]G 0.0 B:A[C>G]G 0.0 N:A[C>G]G 8.0 T:A[C>G]T 1.0 U:A[C>G]T 0.25 B:A[C>G]T 0.0 N:A[C>G]T 8.5 T:A[C>T]A 153.75 U:A[C>T]A 111.5 B:A[C>T]A 0.75 N:A[C>T]A 529.25 T:A[C>T]C 7.5 U:A[C>T]C 5.5 B:A[C>T]C 0.0 N:A[C>T]C 39.5 T:A[C>T]G 13.5 U:A[C>T]G 11.75 B:A[C>T]G 0.0 N:A[C>T]G 73.25 T:A[C>T]T 8.5 U:A[C>T]T 6.75 B:A[C>T]T 0.0 N:A[C>T]T 44.75 T:A[T>A]A 104.0 U:A[T>A]A 76.0 B:A[T>A]A 0.0 N:A[T>A]A 305.5 T:A[T>A]C 1.0 U:A[T>A]C 0.25 B:A[T>A]C 0.0 N:A[T>A]C 6.5 T:A[T>A]G 4.5 U:A[T>A]G 4.75 B:A[T>A]G 0.0 N:A[T>A]G 33.0 T:A[T>A]T 23.25 U:A[T>A]T 20.5 B:A[T>A]T 0.0 N:A[T>A]T 92.5 T:A[T>C]A 156.25 U:A[T>C]A 117.0 B:A[T>C]A 0.25 N:A[T>C]A 548.25 T:A[T>C]C 6.5 U:A[T>C]C 4.25 B:A[T>C]C 0.0 N:A[T>C]C 27.75 T:A[T>C]G 7.5 U:A[T>C]G 4.75 B:A[T>C]G 0.0 N:A[T>C]G 33.75 T:A[T>C]T 5.25 U:A[T>C]T 4.5 B:A[T>C]T 0.0 N:A[T>C]T 35.5 T:A[T>G]A 32.75 U:A[T>G]A 28.25 B:A[T>G]A 0.0 N:A[T>G]A 135.0 T:A[T>G]C 0.25 U:A[T>G]C 0.25 B:A[T>G]C 0.0 N:A[T>G]C 1.5 T:A[T>G]G 1.25 U:A[T>G]G 3.0 B:A[T>G]G 0.0 N:A[T>G]G 16.0 T:A[T>G]T 1.5 U:A[T>G]T 2.5 B:A[T>G]T 0.0 N:A[T>G]T 15.75 T:C[C>A]A 17.5 U:C[C>A]A 11.25 B:C[C>A]A 0.0 N:C[C>A]A 71.25 T:C[C>A]C 1.5 U:C[C>A]C 1.5 B:C[C>A]C 0.0 N:C[C>A]C 12.5 T:C[C>A]G 1.0 U:C[C>A]G 0.75 B:C[C>A]G 0.0 N:C[C>A]G 6.25 T:C[C>A]T 1.75 U:C[C>A]T 3.5 B:C[C>A]T 0.0 N:C[C>A]T 19.75 T:C[C>G]A 0.25 U:C[C>G]A 0.25 B:C[C>G]A 0.0 N:C[C>G]A 2.5 T:C[C>G]C 0.25 U:C[C>G]C 0.75 B:C[C>G]C 0.0 N:C[C>G]C 2.75 T:C[C>G]G 0.0 U:C[C>G]G 0.0 B:C[C>G]G 0.0 N:C[C>G]G 0.0 T:C[C>G]T 0.5 U:C[C>G]T 0.5 B:C[C>G]T 0.0 N:C[C>G]T 5.0 T:C[C>T]A 11.5 U:C[C>T]A 10.5 B:C[C>T]A 0.25 N:C[C>T]A 62.5 T:C[C>T]C 16.0 U:C[C>T]C 15.75 B:C[C>T]C 0.0 N:C[C>T]C 76.5 T:C[C>T]G 8.0 U:C[C>T]G 11.0 B:C[C>T]G 0.0 N:C[C>T]G 44.25 T:C[C>T]T 45.5 U:C[C>T]T 60.25 B:C[C>T]T 0.0 N:C[C>T]T 228.0 T:C[T>A]A 5.5 U:C[T>A]A 3.0 B:C[T>A]A 0.0 N:C[T>A]A 23.25 T:C[T>A]C 30.75 U:C[T>A]C 24.0 B:C[T>A]C 0.0 N:C[T>A]C 118.5 T:C[T>A]G 0.75 U:C[T>A]G 1.0 B:C[T>A]G 0.0 N:C[T>A]G 6.0 T:C[T>A]T 0.25 U:C[T>A]T 0.75 B:C[T>A]T 0.0 N:C[T>A]T 10.25 T:C[T>C]A 5.0 U:C[T>C]A 3.75 B:C[T>C]A 0.0 N:C[T>C]A 26.0 T:C[T>C]C 19.25 U:C[T>C]C 19.75 B:C[T>C]C 0.0 N:C[T>C]C 69.5 T:C[T>C]G 10.0 U:C[T>C]G 11.75 B:C[T>C]G 0.0 N:C[T>C]G 41.75 T:C[T>C]T 39.0 U:C[T>C]T 51.0 B:C[T>C]T 0.0 N:C[T>C]T 193.75 T:C[T>G]A 0.25 U:C[T>G]A 0.0 B:C[T>G]A 0.0 N:C[T>G]A 1.0 T:C[T>G]C 0.25 U:C[T>G]C 0.5 B:C[T>G]C 0.25 N:C[T>G]C 2.0 T:C[T>G]G 0.5 U:C[T>G]G 1.75 B:C[T>G]G 0.0 N:C[T>G]G 5.0 T:C[T>G]T 0.5 U:C[T>G]T 1.25 B:C[T>G]T 0.0 N:C[T>G]T 3.0 T:G[C>A]A 4.0 U:G[C>A]A 1.5 B:G[C>A]A 0.0 N:G[C>A]A 21.5 T:G[C>A]C 0.5 U:G[C>A]C 0.0 B:G[C>A]C 0.0 N:G[C>A]C 4.75 T:G[C>A]G 1.75 U:G[C>A]G 1.75 B:G[C>A]G 0.0 N:G[C>A]G 13.25 T:G[C>A]T 0.0 U:G[C>A]T 0.0 B:G[C>A]T 0.0 N:G[C>A]T 0.5 T:G[C>G]A 1.0 U:G[C>G]A 0.5 B:G[C>G]A 0.0 N:G[C>G]A 9.25 T:G[C>G]C 0.25 U:G[C>G]C 0.25 B:G[C>G]C 0.0 N:G[C>G]C 5.0 T:G[C>G]G 4.5 U:G[C>G]G 4.25 B:G[C>G]G 0.0 N:G[C>G]G 13.5 T:G[C>G]T 0.5 U:G[C>G]T 0.25 B:G[C>G]T 0.0 N:G[C>G]T 2.75 T:G[C>T]A 6.25 U:G[C>T]A 6.5 B:G[C>T]A 0.0 N:G[C>T]A 41.5 T:G[C>T]C 0.5 U:G[C>T]C 1.25 B:G[C>T]C 0.0 N:G[C>T]C 12.75 T:G[C>T]G 10.5 U:G[C>T]G 15.0 B:G[C>T]G 0.0 N:G[C>T]G 53.25 T:G[C>T]T 4.75 U:G[C>T]T 4.5 B:G[C>T]T 0.0 N:G[C>T]T 30.5 T:G[T>A]A 1.75 U:G[T>A]A 1.5 B:G[T>A]A 0.0 N:G[T>A]A 12.5 T:G[T>A]C 0.0 U:G[T>A]C 0.0 B:G[T>A]C 0.0 N:G[T>A]C 0.75 T:G[T>A]G 22.0 U:G[T>A]G 32.25 B:G[T>A]G 0.0 N:G[T>A]G 117.75 T:G[T>A]T 2.0 U:G[T>A]T 2.0 B:G[T>A]T 0.0 N:G[T>A]T 15.75 T:G[T>C]A 1.0 U:G[T>C]A 1.75 B:G[T>C]A 0.0 N:G[T>C]A 16.5 T:G[T>C]C 0.5 U:G[T>C]C 0.25 B:G[T>C]C 0.0 N:G[T>C]C 3.5 T:G[T>C]G 24.0 U:G[T>C]G 23.25 B:G[T>C]G 0.0 N:G[T>C]G 91.75 T:G[T>C]T 1.0 U:G[T>C]T 1.0 B:G[T>C]T 0.0 N:G[T>C]T 14.5 T:G[T>G]A 14.75 U:G[T>G]A 16.75 B:G[T>G]A 0.0 N:G[T>G]A 55.5 T:G[T>G]C 3.5 U:G[T>G]C 3.25 B:G[T>G]C 0.0 N:G[T>G]C 13.25 T:G[T>G]G 56.0 U:G[T>G]G 68.25 B:G[T>G]G 0.25 N:G[T>G]G 170.75 T:G[T>G]T 29.75 U:G[T>G]T 42.25 B:G[T>G]T 0.0 N:G[T>G]T 115.25 T:T[C>A]A 14.5 U:T[C>A]A 12.5 B:T[C>A]A 0.0 N:T[C>A]A 69.5 T:T[C>A]C 0.0 U:T[C>A]C 0.0 B:T[C>A]C 0.0 N:T[C>A]C 1.0 T:T[C>A]G 0.5 U:T[C>A]G 1.25 B:T[C>A]G 0.0 N:T[C>A]G 11.5 T:T[C>A]T 26.25 U:T[C>A]T 30.5 B:T[C>A]T 0.25 N:T[C>A]T 148.75 T:T[C>G]A 2.0 U:T[C>G]A 1.25 B:T[C>G]A 0.0 N:T[C>G]A 16.5 T:T[C>G]C 1.0 U:T[C>G]C 1.5 B:T[C>G]C 0.25 N:T[C>G]C 11.25 T:T[C>G]G 0.0 U:T[C>G]G 0.0 B:T[C>G]G 0.0 N:T[C>G]G 2.25 T:T[C>G]T 30.75 U:T[C>G]T 48.0 B:T[C>G]T 0.0 N:T[C>G]T 145.0 T:T[C>T]A 4.5 U:T[C>T]A 6.5 B:T[C>T]A 0.0 N:T[C>T]A 33.5 T:T[C>T]C 23.75 U:T[C>T]C 34.25 B:T[C>T]C 0.0 N:T[C>T]C 135.5 T:T[C>T]G 0.5 U:T[C>T]G 1.25 B:T[C>T]G 0.0 N:T[C>T]G 17.25 T:T[C>T]T 324.5 U:T[C>T]T 482.5 B:T[C>T]T 4.0 N:T[C>T]T 1317.25 T:T[T>A]A 48.25 U:T[T>A]A 46.75 B:T[T>A]A 0.0 N:T[T>A]A 162.5 T:T[T>A]C 0.25 U:T[T>A]C 0.25 B:T[T>A]C 0.0 N:T[T>A]C 3.0 T:T[T>A]G 0.5 U:T[T>A]G 1.0 B:T[T>A]G 0.0 N:T[T>A]G 5.5 T:T[T>A]T 39.25 U:T[T>A]T 48.25 B:T[T>A]T 0.0 N:T[T>A]T 150.25 T:T[T>C]A 2.25 U:T[T>C]A 3.25 B:T[T>C]A 0.0 N:T[T>C]A 24.5 T:T[T>C]C 38.75 U:T[T>C]C 61.5 B:T[T>C]C 0.5 N:T[T>C]C 206.25 T:T[T>C]G 1.75 U:T[T>C]G 3.75 B:T[T>C]G 0.0 N:T[T>C]G 19.25 T:T[T>C]T 68.5 U:T[T>C]T 97.0 B:T[T>C]T 0.25 N:T[T>C]T 330.5 T:T[T>G]A 0.25 U:T[T>G]A 0.5 B:T[T>G]A 0.0 N:T[T>G]A 3.5 T:T[T>G]C 0.5 U:T[T>G]C 0.75 B:T[T>G]C 0.0 N:T[T>G]C 6.5 T:T[T>G]G 8.0 U:T[T>G]G 15.0 B:T[T>G]G 0.0 N:T[T>G]G 55.5 T:T[T>G]T 53.25 U:T[T>G]T 84.5 B:T[T>G]T 0.25 N:T[T>G]T 248.25 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Transcribed_real_count UnTranscribed_real_count NonTranscribed_real_count Transcribed_mean_sims_count UnTranscribed_mean_sims_count NonTranscribed_mean_sims_count transcribed_versus_untranscribed_p_value transcribed_versus_untranscribed_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Transcribed_real_count.1 Transcribed_mean_sims_count.1 Transcribed_min_sims_count Transcribed_max_sims_count Transcribed_sims_count_list UnTranscribed_real_count.1 UnTranscribed_mean_sims_count.1 UnTranscribed_min_sims_count UnTranscribed_max_sims_count UnTranscribed_sims_count_list NonTranscribed_real_count.1 NonTranscribed_mean_sims_count.1 NonTranscribed_min_sims_count NonTranscribed_max_sims_count NonTranscribed_sims_count_list Prost-AdenoCA SBS58 C>A 281.0 197.0 767.0 288.74 248.68 709.65 0.11314681343896105 0.3146338923901818 13.565 9178.0 Transcribed 1.426 1.161 1.228 1 1 281.0 288.74 254.0 321.0 [254, 264, 277, 297, 295, 305, 267, 293, 303, 265, 318, 292, 286, 282, 315, 289, 298, 302, 302, 303, 285, 268, 301, 306, 286, 278, 276, 294, 304, 293, 297, 285, 280, 290, 276, 279, 270, 302, 289, 303, 292, 301, 304, 301, 288, 292, 309, 321, 282, 284, 312, 309, 290, 283, 280, 299, 285, 283, 296, 267, 283, 277, 292, 272, 295, 292, 307, 303, 270, 295, 276, 312, 282, 281, 266, 273, 288, 289, 283, 296, 287, 286, 283, 294, 305, 297, 290, 316, 289, 268, 271, 275, 283, 266, 293, 313, 277, 266, 267, 269] 197.0 248.68 217.0 292.0 [265, 261, 257, 280, 240, 237, 250, 252, 249, 265, 252, 266, 260, 232, 221, 267, 233, 251, 238, 240, 233, 236, 283, 247, 235, 252, 253, 262, 263, 265, 245, 235, 248, 250, 232, 277, 239, 251, 246, 231, 230, 239, 241, 245, 253, 229, 240, 261, 234, 251, 240, 236, 265, 241, 262, 217, 269, 244, 228, 254, 264, 252, 241, 261, 254, 254, 252, 256, 246, 249, 242, 220, 240, 240, 245, 236, 252, 241, 250, 239, 244, 254, 283, 241, 248, 254, 268, 237, 232, 292, 230, 264, 268, 260, 243, 236, 261, 240, 270, 231] 767.0 709.65 662.0 747.0 [728, 718, 712, 669, 706, 704, 726, 706, 699, 717, 681, 689, 701, 733, 711, 690, 722, 693, 708, 708, 724, 745, 662, 691, 729, 718, 720, 694, 679, 690, 704, 724, 718, 708, 739, 695, 736, 697, 713, 709, 724, 708, 699, 700, 705, 727, 696, 665, 732, 712, 692, 702, 696, 723, 704, 728, 704, 718, 722, 725, 704, 720, 714, 720, 696, 700, 685, 690, 729, 699, 726, 714, 723, 727, 737, 736, 710, 713, 719, 715, 719, 708, 682, 709, 694, 694, 686, 696, 721, 690, 745, 709, 693, 723, 710, 699, 713, 740, 712, 747] Prost-AdenoCA SBS58 C>G 74.0 101.0 307.0 105.39 98.9 278.1 0.07904629820907236 0.23366524092616445 5.252 9178.0 Untranscribed 1.365 0.938 1.454 1 1 1 74.0 105.39 76.0 126.0 [124, 94, 95, 98, 92, 104, 121, 106, 105, 126, 105, 113, 107, 100, 102, 120, 123, 119, 101, 98, 116, 94, 107, 104, 105, 111, 107, 115, 118, 109, 106, 99, 126, 105, 97, 126, 97, 105, 98, 91, 110, 106, 94, 102, 111, 102, 94, 114, 121, 107, 100, 100, 98, 117, 99, 76, 106, 98, 114, 117, 104, 84, 96, 105, 111, 116, 97, 93, 99, 110, 112, 99, 112, 99, 94, 108, 102, 102, 97, 114, 97, 109, 106, 118, 102, 110, 115, 104, 107, 88, 108, 83, 123, 109, 110, 93, 112, 108, 103, 105] 101.0 98.9 79.0 116.0 [94, 101, 100, 101, 105, 89, 106, 114, 90, 98, 91, 103, 111, 114, 95, 98, 106, 103, 93, 84, 101, 105, 98, 104, 112, 102, 90, 97, 104, 105, 104, 115, 94, 98, 107, 93, 96, 109, 105, 102, 96, 88, 99, 93, 90, 99, 102, 92, 84, 98, 91, 93, 100, 98, 90, 115, 106, 96, 83, 91, 101, 116, 104, 100, 113, 100, 102, 89, 97, 100, 98, 100, 89, 106, 80, 85, 97, 103, 99, 96, 108, 93, 112, 79, 98, 107, 103, 96, 79, 106, 107, 116, 88, 96, 102, 106, 103, 88, 90, 97] 307.0 278.1 257.0 307.0 [263, 288, 288, 287, 284, 291, 260, 262, 287, 260, 286, 270, 266, 267, 283, 263, 257, 262, 289, 300, 265, 283, 277, 274, 266, 269, 285, 269, 259, 269, 273, 269, 262, 278, 278, 262, 288, 270, 278, 287, 278, 288, 287, 285, 282, 282, 285, 278, 277, 276, 291, 291, 282, 266, 294, 291, 269, 290, 287, 274, 275, 282, 282, 277, 259, 266, 282, 300, 285, 273, 271, 282, 281, 278, 307, 289, 282, 279, 287, 273, 281, 282, 264, 284, 282, 268, 263, 281, 295, 287, 269, 286, 273, 276, 272, 283, 268, 286, 290, 283] Prost-AdenoCA SBS58 C>T 634.0 792.0 2115.0 766.93 768.1 2010.86 0.003200815720682407 0.012460357719404715 38.581 9178.0 Untranscribed 1.249 1.002 1.247 1 1 634.0 766.93 718.0 820.0 [766, 765, 772, 760, 749, 724, 803, 778, 820, 802, 808, 744, 780, 809, 758, 763, 771, 739, 762, 774, 806, 798, 767, 809, 801, 733, 760, 785, 755, 778, 795, 719, 780, 744, 782, 792, 746, 739, 725, 728, 734, 785, 793, 797, 787, 803, 756, 758, 790, 743, 783, 798, 766, 780, 746, 760, 722, 739, 776, 791, 727, 723, 744, 773, 768, 765, 791, 748, 740, 760, 756, 754, 734, 773, 773, 774, 765, 788, 764, 766, 770, 772, 805, 772, 740, 779, 732, 742, 758, 790, 726, 802, 765, 718, 782, 811, 774, 790, 756, 727] 792.0 768.1 709.0 813.0 [778, 769, 752, 758, 743, 807, 725, 779, 779, 758, 754, 754, 773, 790, 775, 792, 776, 765, 788, 809, 747, 737, 756, 709, 761, 791, 756, 776, 724, 786, 809, 802, 766, 781, 791, 786, 784, 732, 800, 764, 762, 744, 776, 764, 747, 715, 766, 764, 745, 754, 756, 777, 809, 747, 784, 794, 798, 710, 748, 763, 775, 783, 748, 783, 771, 796, 734, 801, 768, 744, 777, 767, 790, 800, 769, 759, 769, 760, 770, 805, 758, 777, 748, 719, 809, 777, 770, 760, 787, 760, 813, 746, 740, 791, 733, 770, 779, 791, 750, 758] 2115.0 2010.86 1941.0 2093.0 [2002, 2004, 2022, 2019, 2051, 2016, 2016, 1989, 1956, 1992, 1984, 2041, 1990, 1947, 2016, 1991, 2003, 2037, 1997, 1963, 1992, 2006, 2020, 2023, 1981, 2019, 2033, 1984, 2064, 1986, 1941, 2028, 2004, 2017, 1975, 1966, 2012, 2078, 2019, 2055, 2048, 2016, 1973, 1978, 2019, 2028, 2030, 2027, 2004, 2040, 2012, 1972, 1977, 2020, 2013, 1997, 2021, 2093, 2017, 1988, 2043, 2038, 2051, 1988, 2011, 1983, 2022, 1996, 2036, 2043, 2013, 2024, 2024, 1974, 2006, 2012, 2016, 2001, 2014, 1980, 2022, 1992, 1998, 2054, 1996, 1994, 2044, 2040, 2001, 1991, 2007, 2002, 2050, 2043, 2033, 1976, 1998, 1962, 2039, 2057] Prost-AdenoCA SBS58 T>A 289.0 280.0 889.0 302.82 322.38 837.83 0.4175018438163074 0.8371105271430942 15.886 9178.0 Transcribed 1.032 0.939 1.099 1 289.0 302.82 258.0 332.0 [281, 288, 305, 325, 305, 278, 284, 273, 305, 328, 328, 313, 313, 293, 308, 321, 306, 318, 326, 313, 314, 307, 312, 290, 307, 327, 285, 291, 300, 310, 289, 328, 303, 297, 312, 288, 310, 277, 308, 296, 306, 316, 298, 310, 295, 285, 307, 301, 300, 281, 323, 284, 321, 304, 295, 291, 297, 258, 286, 298, 314, 297, 305, 322, 299, 332, 305, 301, 296, 310, 297, 283, 298, 319, 308, 299, 315, 300, 304, 324, 297, 320, 313, 314, 282, 291, 329, 289, 311, 281, 295, 314, 305, 285, 287, 306, 287, 313, 327, 290] 280.0 322.38 267.0 374.0 [301, 321, 325, 323, 334, 305, 318, 326, 313, 328, 337, 332, 317, 314, 318, 333, 318, 301, 305, 311, 332, 292, 341, 341, 334, 328, 326, 315, 303, 316, 334, 309, 327, 323, 311, 359, 321, 323, 350, 332, 308, 344, 307, 324, 340, 335, 318, 332, 306, 320, 309, 320, 320, 335, 343, 354, 305, 358, 334, 322, 341, 374, 305, 322, 310, 296, 332, 308, 341, 313, 314, 301, 322, 343, 302, 326, 330, 300, 302, 303, 336, 347, 327, 315, 332, 320, 267, 316, 320, 336, 322, 306, 321, 305, 305, 332, 327, 325, 313, 350] 889.0 837.83 792.0 878.0 [878, 859, 833, 819, 822, 878, 858, 859, 845, 811, 801, 820, 833, 854, 839, 808, 839, 841, 834, 835, 819, 862, 807, 832, 822, 810, 852, 854, 863, 841, 843, 820, 837, 841, 837, 817, 832, 865, 805, 831, 856, 806, 857, 830, 831, 845, 838, 835, 862, 861, 831, 859, 822, 827, 827, 817, 861, 847, 843, 839, 814, 792, 850, 817, 853, 833, 826, 852, 828, 845, 851, 877, 843, 800, 851, 835, 817, 866, 856, 834, 826, 795, 826, 836, 846, 850, 864, 856, 832, 844, 843, 848, 839, 868, 869, 828, 853, 826, 821, 823] Prost-AdenoCA SBS58 T>C 306.0 281.0 1122.0 351.1 366.83 995.74 0.265768951293609 0.6114038855501145 18.621 9178.0 Transcribed 1.089 0.957 1.138 1 306.0 351.1 310.0 396.0 [323, 340, 332, 339, 341, 327, 350, 368, 379, 347, 346, 388, 369, 373, 364, 330, 352, 350, 333, 329, 369, 322, 357, 350, 343, 332, 332, 359, 331, 328, 358, 363, 357, 359, 353, 342, 365, 357, 345, 396, 366, 379, 354, 349, 354, 385, 317, 341, 324, 355, 310, 363, 345, 369, 370, 337, 334, 351, 364, 340, 372, 360, 361, 367, 342, 341, 357, 347, 359, 335, 319, 352, 352, 341, 368, 369, 352, 370, 333, 351, 362, 338, 364, 355, 376, 324, 355, 357, 361, 350, 336, 346, 364, 348, 377, 366, 350, 364, 323, 341] 281.0 366.83 326.0 418.0 [363, 372, 384, 326, 376, 348, 342, 361, 389, 364, 376, 381, 379, 418, 362, 373, 384, 361, 373, 363, 382, 351, 348, 345, 383, 391, 390, 354, 376, 385, 377, 367, 351, 380, 345, 381, 396, 371, 380, 370, 382, 358, 341, 412, 377, 361, 360, 366, 342, 355, 401, 382, 333, 340, 379, 364, 382, 356, 369, 376, 353, 368, 359, 383, 375, 347, 357, 355, 364, 353, 373, 374, 376, 369, 351, 346, 395, 364, 398, 334, 346, 393, 351, 380, 375, 343, 355, 355, 358, 341, 363, 403, 373, 368, 327, 332, 372, 352, 376, 372] 1122.0 995.74 930.0 1047.0 [1030, 1001, 996, 1046, 997, 1039, 1018, 991, 947, 1000, 997, 941, 968, 930, 988, 1007, 975, 1003, 1004, 1023, 964, 1036, 1004, 1017, 990, 993, 992, 996, 1005, 1007, 982, 982, 1004, 979, 1018, 987, 954, 985, 990, 951, 966, 974, 1019, 954, 982, 968, 1040, 1011, 1044, 1001, 997, 966, 1030, 1006, 971, 1013, 1000, 1006, 980, 998, 991, 994, 995, 960, 999, 1029, 997, 1016, 991, 1022, 1020, 984, 985, 1002, 994, 998, 965, 980, 984, 1031, 1007, 982, 998, 975, 969, 1047, 1005, 999, 992, 1024, 1016, 965, 973, 997, 1008, 1017, 989, 996, 1015, 1000] Prost-AdenoCA SBS58 T>G 135.0 151.0 457.0 147.42 167.2 430.66 0.934899130080973 1.0 8.095 9178.0 Untranscribed 1.119 1.134 0.986 135.0 147.42 123.0 178.0 [151, 143, 159, 165, 141, 137, 145, 128, 156, 144, 151, 136, 123, 144, 138, 163, 138, 162, 164, 144, 159, 152, 151, 152, 164, 127, 129, 144, 167, 147, 143, 148, 136, 140, 136, 130, 144, 137, 135, 151, 147, 152, 163, 148, 132, 156, 178, 143, 142, 160, 162, 145, 150, 171, 164, 149, 147, 155, 148, 132, 153, 142, 148, 127, 164, 136, 156, 155, 141, 150, 162, 134, 146, 148, 151, 150, 153, 129, 128, 151, 138, 157, 140, 161, 145, 136, 130, 161, 137, 129, 155, 156, 158, 136, 160, 154, 146, 143, 162, 146] 151.0 167.2 145.0 192.0 [149, 164, 164, 167, 165, 170, 165, 168, 154, 145, 162, 180, 166, 178, 156, 154, 177, 158, 158, 166, 153, 155, 155, 166, 156, 175, 163, 165, 165, 163, 155, 188, 169, 173, 176, 176, 170, 169, 184, 176, 171, 163, 158, 174, 153, 153, 172, 157, 164, 166, 176, 170, 174, 177, 156, 192, 178, 164, 178, 158, 172, 171, 182, 153, 159, 179, 168, 152, 175, 186, 159, 180, 173, 167, 182, 159, 164, 170, 187, 173, 167, 159, 172, 154, 172, 183, 163, 179, 163, 172, 168, 162, 156, 178, 165, 155, 174, 163, 176, 156] 457.0 430.66 397.0 463.0 [445, 438, 424, 415, 436, 438, 435, 447, 435, 455, 433, 430, 456, 425, 451, 427, 429, 426, 426, 438, 435, 439, 436, 432, 428, 443, 452, 435, 412, 437, 448, 411, 439, 432, 434, 439, 430, 437, 426, 417, 425, 430, 422, 426, 463, 436, 397, 443, 439, 419, 411, 429, 421, 400, 424, 404, 418, 423, 419, 453, 423, 431, 414, 463, 423, 428, 419, 438, 431, 412, 423, 432, 424, 429, 412, 437, 433, 445, 432, 423, 438, 430, 432, 432, 426, 423, 452, 410, 445, 445, 422, 427, 430, 432, 420, 434, 429, 441, 409, 444] Skin-Melanoma SBS58 C>A 250.0 117.0 673.0 245.99 196.51 599.57 0.0002852470701586666 0.0012455862209671915 19.597 5307.0 Transcribed 2.137 1.252 1.707 1 1 1 1 250.0 245.99 213.0 288.0 [224, 244, 232, 241, 236, 221, 221, 227, 260, 255, 213, 242, 246, 264, 255, 262, 248, 256, 247, 232, 255, 248, 256, 249, 241, 238, 243, 253, 255, 246, 263, 247, 237, 262, 245, 223, 220, 261, 258, 250, 261, 243, 256, 239, 255, 259, 231, 288, 249, 233, 244, 256, 261, 253, 247, 248, 262, 235, 237, 223, 254, 268, 258, 236, 252, 256, 241, 272, 254, 259, 233, 226, 244, 225, 263, 257, 241, 217, 234, 231, 261, 248, 235, 228, 248, 256, 234, 248, 246, 248, 280, 246, 241, 232, 242, 241, 232, 250, 254, 252] 117.0 196.51 161.0 234.0 [195, 234, 229, 188, 193, 205, 203, 206, 209, 191, 217, 180, 202, 215, 213, 213, 219, 181, 187, 212, 185, 196, 189, 199, 197, 227, 197, 232, 183, 202, 195, 209, 202, 200, 194, 206, 186, 189, 201, 182, 183, 201, 162, 208, 182, 175, 190, 196, 207, 181, 186, 179, 167, 185, 184, 186, 194, 208, 213, 191, 198, 200, 211, 196, 194, 197, 215, 161, 183, 166, 206, 212, 209, 209, 187, 178, 200, 195, 194, 176, 205, 203, 199, 208, 210, 187, 205, 193, 193, 174, 205, 181, 187, 204, 197, 184, 199, 193, 211, 185] 673.0 599.57 558.0 637.0 [623, 567, 582, 616, 611, 616, 618, 608, 575, 596, 614, 618, 595, 561, 576, 570, 579, 605, 605, 598, 602, 598, 597, 593, 602, 576, 606, 564, 603, 594, 585, 587, 600, 580, 604, 611, 637, 590, 583, 608, 600, 598, 624, 594, 607, 607, 622, 558, 588, 631, 608, 606, 613, 606, 609, 608, 583, 600, 593, 625, 590, 576, 572, 611, 599, 588, 587, 610, 605, 617, 603, 605, 588, 606, 593, 609, 602, 628, 611, 635, 573, 589, 606, 608, 583, 596, 607, 600, 603, 618, 560, 613, 615, 609, 603, 617, 610, 598, 577, 604] Skin-Melanoma SBS58 C>G 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5307.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS58 C>T 619.0 985.0 2312.0 824.24 861.99 2232.46 2.768345043398829e-09 1.6676475125506486e-08 73.789 5307.0 Untranscribed 1.591 1.046 1.522 1 1 1 1 619.0 824.24 750.0 895.0 [805, 790, 847, 851, 819, 827, 822, 809, 802, 841, 830, 817, 776, 817, 798, 835, 803, 818, 860, 805, 790, 808, 806, 805, 819, 809, 843, 810, 821, 842, 862, 808, 843, 822, 872, 832, 810, 778, 815, 826, 818, 814, 805, 792, 838, 810, 854, 809, 787, 869, 856, 835, 821, 847, 840, 878, 842, 880, 895, 847, 835, 844, 805, 826, 806, 833, 793, 809, 816, 847, 875, 855, 767, 828, 815, 818, 849, 862, 788, 847, 816, 850, 775, 849, 860, 853, 798, 825, 842, 819, 750, 829, 820, 782, 813, 824, 806, 841, 831, 793] 985.0 861.99 799.0 911.0 [908, 896, 849, 860, 889, 875, 838, 863, 884, 858, 894, 839, 829, 886, 857, 847, 870, 880, 872, 861, 911, 866, 884, 858, 867, 868, 863, 889, 868, 853, 821, 865, 897, 851, 832, 840, 854, 910, 874, 873, 823, 823, 870, 876, 840, 870, 831, 898, 847, 847, 849, 880, 900, 869, 861, 828, 862, 862, 858, 848, 868, 831, 871, 837, 866, 890, 859, 899, 837, 906, 899, 900, 853, 855, 853, 846, 833, 849, 845, 801, 871, 905, 859, 864, 810, 864, 896, 888, 842, 846, 902, 799, 874, 882, 841, 819, 838, 822, 850, 888] 2312.0 2232.46 2150.0 2312.0 [2200, 2234, 2221, 2216, 2212, 2214, 2267, 2249, 2240, 2219, 2199, 2259, 2312, 2217, 2265, 2238, 2263, 2221, 2190, 2256, 2219, 2244, 2221, 2260, 2235, 2249, 2210, 2215, 2225, 2220, 2230, 2242, 2179, 2241, 2209, 2251, 2258, 2223, 2231, 2227, 2276, 2280, 2247, 2244, 2242, 2242, 2235, 2213, 2284, 2200, 2218, 2196, 2196, 2203, 2216, 2210, 2220, 2172, 2169, 2219, 2215, 2247, 2245, 2259, 2244, 2195, 2269, 2209, 2262, 2168, 2150, 2161, 2294, 2241, 2249, 2258, 2235, 2205, 2290, 2267, 2237, 2162, 2292, 2203, 2246, 2197, 2230, 2203, 2237, 2251, 2276, 2283, 2220, 2256, 2265, 2270, 2267, 2251, 2238, 2236] Skin-Melanoma SBS58 T>A 52.0 61.0 206.0 67.49 72.89 180.25 0.7999040661235421 1.0 6.011 5307.0 Untranscribed 1.173 1.08 1.086 52.0 67.49 47.0 89.0 [75, 60, 65, 56, 64, 55, 62, 65, 68, 69, 65, 59, 66, 60, 67, 47, 85, 68, 61, 67, 64, 79, 59, 66, 62, 73, 71, 68, 78, 60, 85, 64, 83, 71, 75, 61, 68, 84, 58, 52, 78, 57, 71, 77, 65, 69, 76, 66, 75, 64, 62, 66, 68, 65, 72, 64, 59, 63, 70, 82, 63, 61, 71, 74, 84, 61, 62, 81, 89, 76, 62, 69, 57, 74, 72, 64, 75, 64, 69, 79, 58, 54, 71, 72, 79, 68, 74, 61, 73, 61, 65, 67, 57, 69, 67, 66, 50, 65, 76, 55] 61.0 72.89 52.0 90.0 [64, 68, 74, 77, 80, 85, 75, 82, 82, 68, 78, 86, 73, 79, 68, 90, 75, 76, 84, 84, 60, 65, 72, 69, 73, 74, 73, 66, 61, 83, 62, 64, 76, 77, 61, 73, 77, 72, 59, 83, 70, 87, 74, 66, 68, 64, 73, 63, 73, 69, 78, 74, 68, 78, 61, 83, 80, 78, 65, 66, 77, 73, 64, 66, 55, 71, 77, 71, 52, 70, 73, 74, 77, 70, 69, 83, 77, 72, 73, 64, 61, 84, 66, 87, 57, 65, 75, 87, 75, 74, 79, 68, 79, 81, 85, 68, 80, 79, 74, 71] 206.0 180.25 160.0 202.0 [180, 192, 181, 188, 177, 182, 185, 173, 171, 183, 178, 175, 182, 181, 186, 185, 160, 177, 176, 171, 197, 175, 189, 185, 186, 174, 176, 186, 181, 176, 176, 191, 166, 172, 184, 187, 176, 166, 202, 186, 172, 175, 174, 179, 187, 186, 172, 192, 172, 188, 181, 180, 185, 178, 186, 174, 182, 180, 186, 175, 181, 186, 186, 181, 183, 187, 181, 169, 179, 174, 185, 176, 187, 177, 179, 173, 169, 183, 180, 178, 200, 182, 184, 162, 184, 186, 170, 177, 172, 184, 176, 187, 186, 173, 170, 185, 192, 177, 170, 196] Skin-Melanoma SBS58 T>C 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5307.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS58 T>G 8.0 4.0 20.0 6.91 6.44 18.79 0.6801722977520502 1.0 0.603 5307.0 Transcribed 2.0 1.073 1.864 1 1 1 1 1 8.0 6.91 2.0 16.0 [2, 6, 9, 8, 7, 5, 7, 6, 11, 7, 6, 8, 5, 8, 10, 8, 8, 4, 8, 6, 5, 11, 5, 7, 6, 5, 6, 4, 6, 9, 9, 6, 5, 6, 3, 8, 10, 7, 5, 9, 9, 9, 7, 2, 9, 3, 10, 9, 7, 4, 6, 6, 8, 6, 8, 4, 6, 7, 6, 6, 5, 3, 9, 9, 6, 8, 5, 5, 10, 10, 5, 6, 6, 5, 10, 7, 16, 4, 4, 6, 7, 6, 6, 9, 6, 8, 7, 4, 11, 7, 4, 9, 10, 7, 6, 8, 8, 6, 13, 7] 4.0 6.44 1.0 13.0 [8, 9, 6, 8, 4, 6, 5, 6, 7, 5, 8, 7, 8, 8, 6, 3, 6, 5, 7, 4, 5, 1, 5, 6, 9, 4, 7, 6, 5, 8, 6, 8, 10, 3, 6, 6, 9, 7, 3, 7, 5, 11, 7, 12, 3, 7, 6, 4, 8, 11, 5, 8, 7, 5, 3, 8, 5, 5, 7, 7, 5, 8, 3, 7, 6, 5, 12, 8, 6, 13, 7, 8, 7, 5, 4, 9, 4, 8, 7, 6, 5, 4, 6, 10, 7, 9, 9, 4, 4, 7, 5, 5, 5, 8, 11, 7, 5, 7, 5, 2] 20.0 18.79 10.0 24.0 [22, 17, 18, 16, 21, 21, 20, 20, 14, 20, 18, 17, 19, 16, 16, 21, 18, 23, 17, 22, 22, 20, 22, 19, 17, 23, 20, 22, 22, 16, 17, 18, 17, 23, 23, 18, 13, 18, 24, 16, 18, 12, 18, 18, 20, 22, 16, 19, 18, 19, 21, 18, 17, 21, 21, 20, 21, 20, 19, 19, 22, 22, 20, 16, 20, 19, 15, 19, 16, 10, 21, 18, 20, 22, 18, 16, 13, 20, 21, 20, 20, 22, 20, 13, 19, 16, 16, 24, 17, 18, 23, 18, 18, 17, 15, 17, 19, 19, 14, 23] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS58 C>A Transcribed ['Skin-Melanoma'] 1 ['Skin-Melanoma'] 1 ['Skin-Melanoma'] 1 ['Skin-Melanoma'] 1 [] 0 [] 0 ['Prost-AdenoCA', 'Skin-Melanoma'] 2 SBS58 C>T Untranscribed ['Prost-AdenoCA', 'Skin-Melanoma'] 2 ['Prost-AdenoCA', 'Skin-Melanoma'] 2 ['Skin-Melanoma'] 1 ['Skin-Melanoma'] 1 [] 0 [] 0 ['Prost-AdenoCA', 'Skin-Melanoma'] 2