# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 649.709 E:A[C>A]A 684.278 A:A[C>G]A 187.83 E:A[C>G]A 206.775 A:A[C>T]A 730.072 E:A[C>T]A 745.289 A:A[T>A]A 445.222 E:A[T>A]A 457.087 A:A[T>C]A 724.101 E:A[T>C]A 750.448 A:A[T>G]A 185.429 E:A[T>G]A 201.396 A:A[C>A]C 74.454 E:A[C>A]C 74.909 A:A[C>G]C 21.748 E:A[C>G]C 21.88 A:A[C>T]C 61.592 E:A[C>T]C 63.01 A:A[T>A]C 16.232 E:A[T>A]C 16.174 A:A[T>C]C 49.913 E:A[T>C]C 50.508 A:A[T>G]C 8.694 E:A[T>G]C 8.825 A:A[C>A]G 14.153 E:A[C>A]G 13.963 A:A[C>G]G 18.047 E:A[C>G]G 17.364 A:A[C>T]G 101.181 E:A[C>T]G 103.145 A:A[T>A]G 51.026 E:A[T>A]G 50.317 A:A[T>C]G 52.948 E:A[T>C]G 56.562 A:A[T>G]G 29.156 E:A[T>G]G 30.049 A:A[C>A]T 57.307 E:A[C>A]T 60.78 A:A[C>G]T 18.404 E:A[C>G]T 19.107 A:A[C>T]T 72.142 E:A[C>T]T 69.591 A:A[T>A]T 135.22 E:A[T>A]T 139.131 A:A[T>C]T 54.964 E:A[T>C]T 55.856 A:A[T>G]T 28.524 E:A[T>G]T 28.875 A:C[C>A]A 97.038 E:C[C>A]A 111.526 A:C[C>G]A 8.045 E:C[C>G]A 8.223 A:C[C>T]A 90.968 E:C[C>T]A 93.028 A:C[T>A]A 38.411 E:C[T>A]A 45.514 A:C[T>C]A 45.872 E:C[T>C]A 45.652 A:C[T>G]A 5.591 E:C[T>G]A 6.456 A:C[C>A]C 24.154 E:C[C>A]C 25.755 A:C[C>G]C 10.501 E:C[C>G]C 11.96 A:C[C>T]C 114.951 E:C[C>T]C 115.55 A:C[T>A]C 164.362 E:C[T>A]C 171.043 A:C[T>C]C 113.803 E:C[T>C]C 111.315 A:C[T>G]C 9.55 E:C[T>G]C 9.177 A:C[C>A]G 15.51 E:C[C>A]G 17.481 A:C[C>G]G 0.767 E:C[C>G]G 0.767 A:C[C>T]G 75.339 E:C[C>T]G 72.535 A:C[T>A]G 15.763 E:C[T>A]G 14.162 A:C[T>C]G 72.564 E:C[T>C]G 73.754 A:C[T>G]G 11.992 E:C[T>G]G 12.19 A:C[C>A]T 32.585 E:C[C>A]T 34.106 A:C[C>G]T 12.244 E:C[C>G]T 11.931 A:C[C>T]T 326.047 E:C[C>T]T 325.531 A:C[T>A]T 18.984 E:C[T>A]T 19.908 A:C[T>C]T 293.229 E:C[T>C]T 271.177 A:C[T>G]T 8.791 E:C[T>G]T 7.638 A:G[C>A]A 32.874 E:G[C>A]A 35.966 A:G[C>G]A 21.913 E:G[C>G]A 22.365 A:G[C>T]A 64.74 E:G[C>T]A 68.811 A:G[T>A]A 26.456 E:G[T>A]A 25.349 A:G[T>C]A 29.574 E:G[T>C]A 29.632 A:G[T>G]A 98.018 E:G[T>G]A 92.383 A:G[C>A]C 13.159 E:G[C>A]C 11.435 A:G[C>G]C 14.331 E:G[C>G]C 13.39 A:G[C>T]C 26.28 E:G[C>T]C 26.478 A:G[T>A]C 6.688 E:G[T>A]C 6.438 A:G[T>C]C 11.14 E:G[T>C]C 10.357 A:G[T>G]C 29.717 E:G[T>G]C 26.552 A:G[C>A]G 29.54 E:G[C>A]G 26.949 A:G[C>G]G 29.336 E:G[C>G]G 28.573 A:G[C>T]G 89.502 E:G[C>T]G 87.753 A:G[T>A]G 174.67 E:G[T>A]G 168.638 A:G[T>C]G 144.319 E:G[T>C]G 133.714 A:G[T>G]G 291.419 E:G[T>G]G 282.779 A:G[C>A]T 4.115 E:G[C>A]T 3.698 A:G[C>G]T 8.187 E:G[C>G]T 9.02 A:G[C>T]T 48.596 E:G[C>T]T 48.334 A:G[T>A]T 31.994 E:G[T>A]T 26.195 A:G[T>C]T 27.595 E:G[T>C]T 26.514 A:G[T>G]T 186.195 E:G[T>G]T 183.627 A:T[C>A]A 99.389 E:T[C>A]A 105.082 A:T[C>G]A 30.572 E:T[C>G]A 27.715 A:T[C>T]A 54.857 E:T[C>T]A 56.306 A:T[T>A]A 246.239 E:T[T>A]A 243.637 A:T[T>C]A 38.476 E:T[T>C]A 41.846 A:T[T>G]A 10.644 E:T[T>G]A 10.731 A:T[C>A]C 4.541 E:T[C>A]C 4.764 A:T[C>G]C 21.439 E:T[C>G]C 22.593 A:T[C>T]C 204.058 E:T[C>T]C 197.154 A:T[T>A]C 9.462 E:T[T>A]C 8.977 A:T[T>C]C 310.22 E:T[T>C]C 290.785 A:T[T>G]C 15.629 E:T[T>G]C 13.026 A:T[C>A]G 24.854 E:T[C>A]G 26.794 A:T[C>G]G 8.456 E:T[C>G]G 7.91 A:T[C>T]G 30.948 E:T[C>T]G 30.663 A:T[T>A]G 13.076 E:T[T>A]G 12.3 A:T[T>C]G 33.441 E:T[T>C]G 31.339 A:T[T>G]G 93.633 E:T[T>G]G 89.304 A:T[C>A]T 202.259 E:T[C>A]T 188.402 A:T[C>G]T 230.708 E:T[C>G]T 225.88 A:T[C>T]T 2012.004 E:T[C>T]T 1902.79 A:T[T>A]T 229.94 E:T[T>A]T 220.062 A:T[T>C]T 482.94 E:T[T>C]T 448.032 A:T[T>G]T 370.953 E:T[T>G]T 358.29 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Prost-AdenoCA SBS58 C>A 533.0 588.0 554.69 570.05 0.4224102299014957 0.8429556786362005 13.544 8277.0 Leading 1.103 1.028 1.073 533.0 554.69 496.0 600.0 [548, 531, 496, 538, 547, 545, 554, 570, 561, 559, 555, 564, 531, 563, 519, 551, 557, 595, 537, 525, 551, 562, 566, 553, 550, 535, 578, 535, 537, 554, 568, 587, 538, 567, 580, 527, 546, 534, 559, 549, 564, 575, 563, 555, 600, 579, 575, 528, 552, 561, 588, 546, 554, 558, 552, 524, 549, 565, 554, 555, 540, 547, 578, 551, 550, 520, 583, 567, 587, 554, 549, 580, 533, 555, 562, 501, 548, 556, 576, 558, 557, 552, 562, 587, 556, 561, 550, 552, 548, 551, 552, 541, 559, 579, 553, 567, 578, 532, 553, 565] 588.0 570.05 529.0 617.0 [571, 593, 607, 587, 571, 579, 556, 579, 565, 569, 574, 580, 608, 564, 603, 583, 572, 544, 584, 596, 572, 561, 553, 582, 550, 597, 541, 589, 579, 562, 554, 529, 588, 555, 539, 598, 591, 595, 572, 573, 559, 567, 573, 563, 536, 552, 535, 598, 561, 551, 548, 591, 570, 563, 568, 597, 571, 558, 572, 577, 581, 594, 551, 568, 587, 615, 553, 540, 544, 557, 575, 555, 590, 565, 557, 617, 568, 575, 557, 571, 570, 579, 554, 532, 561, 557, 556, 576, 573, 573, 573, 578, 566, 554, 561, 557, 544, 590, 580, 576] Prost-AdenoCA SBS58 C>G 210.0 226.0 216.42 218.1 0.6840866004497195 1.0 5.268 8277.0 Leading 1.076 1.008 1.068 210.0 216.42 187.0 239.0 [206, 213, 219, 237, 222, 192, 228, 217, 223, 227, 208, 229, 231, 219, 197, 200, 215, 216, 214, 211, 215, 217, 226, 216, 198, 211, 218, 207, 216, 225, 211, 225, 224, 217, 221, 224, 207, 203, 206, 223, 201, 217, 218, 238, 208, 219, 209, 226, 223, 221, 239, 232, 227, 210, 230, 216, 214, 227, 213, 223, 212, 219, 221, 224, 213, 223, 221, 221, 209, 221, 211, 196, 215, 217, 204, 234, 234, 211, 211, 210, 225, 237, 226, 211, 224, 187, 207, 203, 214, 208, 227, 214, 219, 202, 214, 214, 204, 209, 212, 213] 226.0 218.1 190.0 250.0 [229, 229, 208, 203, 211, 239, 216, 226, 216, 215, 218, 215, 202, 214, 233, 231, 221, 222, 227, 220, 208, 215, 203, 228, 230, 231, 205, 223, 215, 215, 217, 211, 215, 219, 213, 215, 224, 220, 235, 210, 232, 218, 212, 193, 225, 224, 223, 214, 211, 215, 202, 207, 204, 227, 203, 219, 224, 214, 224, 209, 217, 217, 215, 218, 212, 211, 218, 215, 235, 205, 223, 241, 213, 205, 230, 207, 209, 234, 211, 229, 210, 190, 207, 210, 218, 250, 227, 237, 221, 218, 208, 224, 223, 224, 210, 216, 227, 235, 216, 227] Prost-AdenoCA SBS58 C>T 1624.0 1555.0 1606.9 1595.29 0.4678245461904688 0.8966901622283733 38.408 8277.0 Lagging 1.044 1.007 1.037 1624.0 1606.9 1555.0 1671.0 [1597, 1618, 1602, 1580, 1579, 1645, 1612, 1581, 1613, 1581, 1635, 1604, 1654, 1657, 1620, 1644, 1593, 1559, 1594, 1621, 1562, 1610, 1590, 1633, 1609, 1671, 1557, 1597, 1584, 1606, 1643, 1623, 1605, 1654, 1573, 1611, 1597, 1581, 1633, 1593, 1611, 1646, 1567, 1594, 1600, 1628, 1619, 1578, 1612, 1623, 1650, 1643, 1582, 1627, 1609, 1579, 1624, 1601, 1600, 1583, 1594, 1653, 1565, 1578, 1627, 1560, 1587, 1609, 1589, 1598, 1610, 1665, 1559, 1618, 1625, 1650, 1615, 1575, 1584, 1604, 1633, 1569, 1555, 1662, 1602, 1578, 1626, 1643, 1589, 1589, 1631, 1596, 1654, 1589, 1575, 1602, 1605, 1595, 1601, 1634] 1555.0 1595.29 1531.0 1676.0 [1581, 1595, 1594, 1630, 1609, 1578, 1599, 1637, 1590, 1605, 1581, 1593, 1560, 1531, 1612, 1568, 1625, 1644, 1594, 1568, 1649, 1589, 1589, 1531, 1568, 1552, 1663, 1608, 1592, 1623, 1543, 1554, 1586, 1546, 1634, 1603, 1612, 1610, 1567, 1612, 1602, 1568, 1617, 1616, 1621, 1610, 1598, 1676, 1568, 1574, 1564, 1569, 1600, 1579, 1617, 1617, 1592, 1619, 1583, 1591, 1592, 1576, 1621, 1626, 1568, 1662, 1597, 1575, 1602, 1594, 1570, 1541, 1633, 1607, 1608, 1537, 1589, 1609, 1608, 1625, 1584, 1647, 1656, 1555, 1574, 1625, 1584, 1534, 1614, 1608, 1559, 1592, 1537, 1605, 1647, 1614, 1598, 1598, 1593, 1559] Prost-AdenoCA SBS58 T>A 653.0 668.0 668.57 649.85 0.5083134435227679 0.938329014252009 15.96 8277.0 Leading 1.023 0.972 1.052 653.0 668.57 616.0 714.0 [676, 680, 671, 664, 663, 655, 667, 683, 695, 659, 669, 690, 653, 662, 676, 683, 628, 659, 673, 652, 677, 672, 672, 659, 682, 633, 664, 674, 686, 676, 687, 681, 660, 660, 653, 657, 689, 686, 643, 700, 616, 688, 663, 632, 667, 656, 673, 657, 667, 683, 665, 675, 672, 678, 645, 659, 642, 649, 679, 646, 650, 667, 685, 624, 668, 631, 677, 661, 673, 627, 679, 676, 665, 672, 714, 660, 651, 668, 660, 707, 676, 654, 702, 681, 677, 647, 690, 682, 698, 659, 684, 661, 678, 711, 693, 688, 649, 681, 683, 667] 668.0 649.85 607.0 708.0 [629, 637, 665, 644, 647, 641, 669, 651, 624, 677, 661, 626, 659, 645, 654, 623, 708, 653, 663, 671, 630, 610, 649, 680, 637, 696, 654, 650, 616, 653, 624, 654, 652, 653, 647, 684, 611, 636, 672, 621, 702, 634, 668, 693, 636, 651, 631, 660, 638, 647, 660, 645, 642, 643, 679, 660, 650, 664, 638, 676, 669, 633, 631, 684, 643, 691, 640, 653, 652, 680, 646, 645, 644, 630, 614, 656, 669, 661, 646, 634, 639, 679, 607, 643, 643, 671, 617, 656, 637, 659, 636, 650, 654, 611, 634, 639, 664, 634, 648, 650] Prost-AdenoCA SBS58 T>C 806.0 730.0 775.12 763.05 0.24845931563311455 0.5798923432403609 18.557 8277.0 Lagging 1.104 1.016 1.087 806.0 775.12 725.0 820.0 [773, 775, 787, 791, 768, 759, 761, 807, 753, 757, 778, 742, 789, 758, 769, 771, 759, 768, 737, 750, 760, 784, 794, 775, 779, 746, 802, 794, 753, 797, 763, 801, 764, 755, 780, 778, 782, 809, 779, 791, 776, 793, 748, 806, 776, 786, 797, 725, 745, 742, 787, 759, 792, 756, 781, 778, 805, 759, 765, 781, 773, 778, 730, 764, 768, 749, 776, 794, 808, 820, 772, 805, 754, 760, 769, 756, 797, 770, 764, 791, 780, 789, 756, 784, 801, 762, 757, 804, 791, 816, 791, 786, 780, 786, 767, 767, 787, 770, 758, 787] 730.0 763.05 722.0 813.0 [773, 773, 752, 763, 767, 787, 786, 736, 784, 773, 755, 808, 740, 769, 760, 757, 759, 765, 787, 781, 762, 739, 732, 762, 762, 798, 743, 731, 782, 740, 764, 742, 770, 784, 746, 771, 746, 733, 748, 738, 762, 757, 785, 722, 769, 738, 751, 803, 803, 801, 741, 773, 745, 767, 767, 752, 732, 792, 796, 750, 778, 762, 813, 753, 775, 789, 770, 746, 730, 740, 776, 724, 775, 787, 763, 780, 751, 776, 766, 769, 761, 758, 775, 765, 757, 783, 799, 743, 751, 722, 730, 765, 764, 746, 768, 782, 752, 787, 772, 728] Prost-AdenoCA SBS58 T>G 359.0 325.0 340.28 331.66 0.5145004453872803 0.9429726781254711 8.264 8277.0 Lagging 1.105 1.026 1.077 359.0 340.28 307.0 383.0 [322, 359, 372, 312, 324, 312, 350, 339, 325, 336, 323, 352, 346, 337, 330, 339, 355, 383, 350, 345, 342, 336, 333, 346, 345, 342, 358, 326, 347, 317, 345, 328, 321, 325, 339, 344, 335, 350, 338, 347, 340, 336, 316, 350, 361, 370, 334, 331, 350, 338, 333, 339, 324, 353, 332, 326, 307, 318, 331, 350, 367, 349, 320, 367, 353, 340, 347, 314, 357, 331, 330, 340, 346, 333, 358, 345, 338, 319, 359, 351, 347, 323, 328, 338, 345, 358, 321, 341, 350, 358, 336, 339, 352, 353, 328, 354, 339, 352, 346, 342] 325.0 331.66 301.0 365.0 [342, 316, 301, 365, 349, 344, 319, 345, 342, 339, 342, 322, 324, 323, 345, 332, 325, 305, 318, 314, 329, 336, 337, 338, 331, 336, 318, 344, 312, 351, 323, 341, 354, 350, 326, 321, 336, 322, 335, 314, 332, 337, 353, 341, 321, 302, 341, 341, 326, 340, 345, 323, 350, 322, 337, 333, 356, 344, 332, 315, 313, 329, 349, 324, 321, 335, 338, 355, 320, 334, 346, 339, 323, 336, 311, 320, 333, 353, 317, 314, 328, 348, 333, 334, 329, 309, 361, 328, 323, 309, 335, 329, 324, 323, 342, 317, 337, 325, 332, 333] Skin-Melanoma SBS58 C>A 435.0 483.0 453.84 476.65 0.5763005851154958 1.0 19.478 4713.0 Leading 1.11 1.05 1.057 435.0 453.84 390.0 499.0 [460, 444, 470, 458, 450, 460, 450, 474, 476, 423, 426, 451, 450, 461, 453, 494, 466, 475, 465, 451, 448, 430, 424, 450, 469, 480, 465, 390, 453, 449, 414, 473, 470, 437, 472, 459, 442, 451, 464, 442, 476, 449, 429, 463, 435, 451, 442, 457, 422, 446, 448, 472, 430, 451, 470, 437, 460, 440, 499, 442, 456, 473, 445, 462, 467, 454, 472, 459, 491, 445, 475, 435, 435, 446, 448, 455, 445, 449, 453, 434, 459, 464, 467, 467, 461, 468, 461, 458, 439, 437, 436, 453, 458, 474, 431, 478, 467, 457, 449, 443] 483.0 476.65 435.0 531.0 [473, 491, 464, 463, 477, 477, 469, 465, 473, 514, 481, 473, 496, 471, 468, 447, 458, 463, 473, 483, 489, 487, 492, 481, 466, 467, 483, 531, 475, 488, 521, 460, 442, 487, 456, 484, 478, 492, 459, 492, 449, 481, 495, 471, 489, 474, 477, 481, 482, 487, 485, 484, 505, 470, 470, 491, 475, 493, 435, 485, 471, 463, 479, 487, 463, 464, 466, 473, 438, 476, 461, 490, 492, 479, 494, 475, 486, 469, 479, 493, 474, 464, 473, 454, 465, 453, 474, 482, 497, 463, 510, 467, 464, 472, 488, 462, 464, 475, 494, 484] Skin-Melanoma SBS58 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4713.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS58 C>T 1823.0 1667.0 1773.71 1730.74 0.18029558967757212 0.4571506526691143 74.05 4713.0 Lagging 1.094 1.025 1.067 1823.0 1773.71 1687.0 1841.0 [1809, 1756, 1746, 1838, 1773, 1793, 1731, 1757, 1795, 1757, 1690, 1789, 1732, 1747, 1749, 1802, 1841, 1801, 1754, 1733, 1708, 1808, 1786, 1821, 1770, 1776, 1762, 1774, 1788, 1777, 1701, 1757, 1788, 1805, 1739, 1819, 1719, 1748, 1770, 1773, 1835, 1789, 1759, 1830, 1745, 1815, 1798, 1794, 1798, 1759, 1761, 1784, 1813, 1731, 1806, 1742, 1786, 1807, 1738, 1766, 1735, 1717, 1802, 1814, 1777, 1777, 1761, 1747, 1741, 1687, 1766, 1783, 1797, 1788, 1802, 1781, 1783, 1777, 1783, 1770, 1789, 1802, 1803, 1759, 1813, 1760, 1762, 1749, 1775, 1768, 1788, 1798, 1810, 1757, 1751, 1735, 1832, 1720, 1773, 1801] 1667.0 1730.74 1643.0 1804.0 [1733, 1779, 1748, 1687, 1767, 1715, 1770, 1766, 1711, 1750, 1792, 1722, 1754, 1736, 1765, 1676, 1700, 1720, 1755, 1747, 1787, 1721, 1704, 1708, 1776, 1708, 1732, 1735, 1727, 1719, 1804, 1706, 1724, 1693, 1777, 1680, 1778, 1739, 1715, 1741, 1643, 1732, 1768, 1673, 1787, 1691, 1722, 1691, 1708, 1763, 1730, 1705, 1713, 1782, 1735, 1778, 1716, 1686, 1766, 1749, 1793, 1755, 1667, 1707, 1725, 1696, 1729, 1771, 1760, 1801, 1770, 1703, 1729, 1714, 1690, 1739, 1737, 1735, 1747, 1730, 1710, 1697, 1656, 1736, 1694, 1761, 1743, 1773, 1724, 1700, 1691, 1694, 1682, 1755, 1760, 1792, 1653, 1760, 1689, 1701] Skin-Melanoma SBS58 T>A 133.0 142.0 142.37 142.05 0.7352238827626449 1.0 5.835 4713.0 Leading 1.068 0.998 1.07 133.0 142.37 120.0 163.0 [141, 131, 130, 156, 138, 154, 149, 142, 135, 136, 122, 152, 132, 136, 141, 146, 159, 148, 146, 126, 139, 137, 140, 144, 132, 148, 150, 150, 144, 144, 138, 144, 148, 134, 142, 128, 129, 139, 120, 139, 145, 154, 134, 163, 140, 151, 149, 142, 141, 136, 140, 158, 126, 158, 145, 153, 136, 139, 149, 138, 156, 138, 150, 141, 125, 142, 135, 146, 146, 145, 147, 139, 141, 144, 144, 144, 149, 141, 147, 137, 152, 141, 145, 141, 126, 143, 144, 137, 146, 139, 145, 150, 141, 152, 137, 148, 150, 141, 149, 147] 142.0 142.05 119.0 169.0 [145, 152, 143, 128, 136, 129, 134, 144, 146, 143, 169, 136, 146, 153, 150, 140, 136, 131, 143, 161, 140, 145, 147, 143, 163, 135, 136, 127, 130, 144, 146, 140, 141, 145, 139, 153, 152, 149, 153, 143, 139, 130, 141, 120, 143, 138, 130, 147, 141, 142, 138, 124, 155, 125, 140, 135, 142, 140, 127, 148, 132, 150, 147, 146, 166, 153, 150, 135, 143, 143, 139, 139, 144, 145, 143, 145, 142, 136, 131, 151, 119, 149, 141, 148, 156, 149, 150, 146, 139, 145, 146, 131, 148, 131, 158, 132, 139, 145, 134, 138] Skin-Melanoma SBS58 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4713.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS58 T>G 17.0 13.0 14.28 14.44 0.7925917647721559 1.0 0.637 4713.0 Lagging 1.308 0.989 1.322 1 1 1 17.0 14.28 9.0 22.0 [13, 13, 18, 11, 16, 16, 15, 10, 12, 14, 15, 11, 17, 12, 14, 16, 16, 16, 17, 14, 16, 18, 18, 14, 19, 16, 14, 14, 15, 10, 11, 12, 9, 16, 17, 10, 12, 14, 20, 15, 12, 14, 12, 13, 16, 11, 14, 12, 13, 13, 16, 10, 14, 11, 15, 14, 17, 12, 22, 14, 14, 14, 14, 16, 18, 12, 13, 15, 15, 12, 12, 13, 14, 12, 16, 17, 15, 16, 18, 18, 16, 12, 17, 11, 18, 13, 12, 13, 13, 14, 16, 14, 12, 10, 13, 12, 18, 13, 16, 20] 13.0 14.44 6.0 21.0 [16, 15, 9, 18, 13, 14, 13, 20, 17, 13, 17, 18, 12, 16, 14, 14, 11, 10, 12, 14, 14, 12, 11, 11, 12, 14, 15, 10, 15, 18, 18, 16, 21, 14, 13, 19, 16, 14, 9, 14, 16, 13, 17, 16, 11, 17, 16, 16, 16, 18, 15, 17, 14, 18, 11, 12, 12, 16, 6, 14, 16, 15, 15, 10, 10, 14, 15, 14, 13, 18, 20, 15, 15, 18, 11, 12, 9, 13, 13, 12, 12, 18, 13, 18, 10, 18, 16, 18, 15, 15, 14, 16, 18, 19, 15, 17, 14, 15, 13, 9] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change