# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types. MutationType Across_All_Cancer_Types T:A[C>A]A 76.333 U:A[C>A]A 53.667 B:A[C>A]A 0.667 N:A[C>A]A 221.333 T:A[C>A]C 6.333 U:A[C>A]C 6.0 B:A[C>A]C 0.0 N:A[C>A]C 23.0 T:A[C>A]G 4.667 U:A[C>A]G 5.0 B:A[C>A]G 0.0 N:A[C>A]G 21.0 T:A[C>A]T 24.667 U:A[C>A]T 22.667 B:A[C>A]T 0.0 N:A[C>A]T 97.0 T:A[C>G]A 53.333 U:A[C>G]A 34.667 B:A[C>G]A 0.0 N:A[C>G]A 156.0 T:A[C>G]C 6.333 U:A[C>G]C 5.667 B:A[C>G]C 0.0 N:A[C>G]C 22.0 T:A[C>G]G 2.667 U:A[C>G]G 2.667 B:A[C>G]G 0.0 N:A[C>G]G 6.333 T:A[C>G]T 6.0 U:A[C>G]T 6.667 B:A[C>G]T 0.0 N:A[C>G]T 25.0 T:A[C>T]A 137.333 U:A[C>T]A 106.667 B:A[C>T]A 2.333 N:A[C>T]A 394.333 T:A[C>T]C 45.0 U:A[C>T]C 43.0 B:A[C>T]C 0.333 N:A[C>T]C 143.333 T:A[C>T]G 71.333 U:A[C>T]G 64.0 B:A[C>T]G 0.667 N:A[C>T]G 157.667 T:A[C>T]T 32.0 U:A[C>T]T 27.333 B:A[C>T]T 0.333 N:A[C>T]T 92.0 T:A[T>A]A 11.667 U:A[T>A]A 7.667 B:A[T>A]A 0.0 N:A[T>A]A 35.0 T:A[T>A]C 27.0 U:A[T>A]C 20.333 B:A[T>A]C 0.0 N:A[T>A]C 77.667 T:A[T>A]G 10.333 U:A[T>A]G 13.667 B:A[T>A]G 0.0 N:A[T>A]G 45.667 T:A[T>A]T 35.0 U:A[T>A]T 35.333 B:A[T>A]T 0.667 N:A[T>A]T 112.667 T:A[T>C]A 77.333 U:A[T>C]A 72.333 B:A[T>C]A 1.0 N:A[T>C]A 254.0 T:A[T>C]C 27.667 U:A[T>C]C 28.333 B:A[T>C]C 0.0 N:A[T>C]C 90.333 T:A[T>C]G 28.333 U:A[T>C]G 31.0 B:A[T>C]G 0.0 N:A[T>C]G 95.0 T:A[T>C]T 31.667 U:A[T>C]T 37.0 B:A[T>C]T 0.0 N:A[T>C]T 141.333 T:A[T>G]A 10.0 U:A[T>G]A 9.667 B:A[T>G]A 0.0 N:A[T>G]A 49.333 T:A[T>G]C 2.333 U:A[T>G]C 2.667 B:A[T>G]C 0.0 N:A[T>G]C 9.667 T:A[T>G]G 1.667 U:A[T>G]G 1.333 B:A[T>G]G 0.0 N:A[T>G]G 8.333 T:A[T>G]T 13.667 U:A[T>G]T 27.667 B:A[T>G]T 0.0 N:A[T>G]T 95.333 T:C[C>A]A 90.333 U:C[C>A]A 81.667 B:C[C>A]A 1.333 N:C[C>A]A 279.333 T:C[C>A]C 17.333 U:C[C>A]C 17.667 B:C[C>A]C 0.0 N:C[C>A]C 63.0 T:C[C>A]G 5.0 U:C[C>A]G 5.667 B:C[C>A]G 0.0 N:C[C>A]G 11.667 T:C[C>A]T 36.667 U:C[C>A]T 39.333 B:C[C>A]T 0.333 N:C[C>A]T 125.667 T:C[C>G]A 1.0 U:C[C>G]A 0.667 B:C[C>G]A 0.0 N:C[C>G]A 3.333 T:C[C>G]C 2.333 U:C[C>G]C 2.667 B:C[C>G]C 0.0 N:C[C>G]C 13.0 T:C[C>G]G 0.333 U:C[C>G]G 1.667 B:C[C>G]G 0.0 N:C[C>G]G 1.667 T:C[C>G]T 2.667 U:C[C>G]T 2.333 B:C[C>G]T 0.0 N:C[C>G]T 17.0 T:C[C>T]A 57.667 U:C[C>T]A 53.333 B:C[C>T]A 0.333 N:C[C>T]A 196.333 T:C[C>T]C 76.667 U:C[C>T]C 78.0 B:C[C>T]C 1.0 N:C[C>T]C 241.0 T:C[C>T]G 30.0 U:C[C>T]G 31.0 B:C[C>T]G 0.0 N:C[C>T]G 69.333 T:C[C>T]T 107.667 U:C[C>T]T 115.333 B:C[C>T]T 2.0 N:C[C>T]T 371.667 T:C[T>A]A 14.667 U:C[T>A]A 14.667 B:C[T>A]A 0.0 N:C[T>A]A 52.667 T:C[T>A]C 52.0 U:C[T>A]C 39.0 B:C[T>A]C 0.0 N:C[T>A]C 127.333 T:C[T>A]G 5.0 U:C[T>A]G 5.0 B:C[T>A]G 0.0 N:C[T>A]G 18.667 T:C[T>A]T 33.333 U:C[T>A]T 41.0 B:C[T>A]T 0.0 N:C[T>A]T 146.333 T:C[T>C]A 37.0 U:C[T>C]A 36.0 B:C[T>C]A 0.333 N:C[T>C]A 127.333 T:C[T>C]C 18.667 U:C[T>C]C 19.333 B:C[T>C]C 0.0 N:C[T>C]C 64.0 T:C[T>C]G 30.0 U:C[T>C]G 32.333 B:C[T>C]G 0.0 N:C[T>C]G 92.0 T:C[T>C]T 106.667 U:C[T>C]T 148.333 B:C[T>C]T 2.0 N:C[T>C]T 433.333 T:C[T>G]A 0.0 U:C[T>G]A 0.0 B:C[T>G]A 0.0 N:C[T>G]A 1.667 T:C[T>G]C 4.0 U:C[T>G]C 5.0 B:C[T>G]C 0.0 N:C[T>G]C 13.333 T:C[T>G]G 7.667 U:C[T>G]G 9.333 B:C[T>G]G 0.0 N:C[T>G]G 24.667 T:C[T>G]T 42.667 U:C[T>G]T 44.333 B:C[T>G]T 0.333 N:C[T>G]T 193.0 T:G[C>A]A 10.0 U:G[C>A]A 10.0 B:G[C>A]A 0.0 N:G[C>A]A 48.667 T:G[C>A]C 2.333 U:G[C>A]C 2.333 B:G[C>A]C 0.0 N:G[C>A]C 8.333 T:G[C>A]G 0.0 U:G[C>A]G 0.0 B:G[C>A]G 0.0 N:G[C>A]G 0.0 T:G[C>A]T 8.667 U:G[C>A]T 9.333 B:G[C>A]T 0.0 N:G[C>A]T 31.333 T:G[C>G]A 7.667 U:G[C>G]A 4.667 B:G[C>G]A 0.0 N:G[C>G]A 21.333 T:G[C>G]C 6.333 U:G[C>G]C 6.333 B:G[C>G]C 0.0 N:G[C>G]C 17.333 T:G[C>G]G 1.667 U:G[C>G]G 1.333 B:G[C>G]G 0.0 N:G[C>G]G 6.0 T:G[C>G]T 0.0 U:G[C>G]T 0.333 B:G[C>G]T 0.0 N:G[C>G]T 2.333 T:G[C>T]A 13.333 U:G[C>T]A 13.333 B:G[C>T]A 0.0 N:G[C>T]A 42.333 T:G[C>T]C 26.0 U:G[C>T]C 26.667 B:G[C>T]C 0.0 N:G[C>T]C 78.333 T:G[C>T]G 38.0 U:G[C>T]G 41.0 B:G[C>T]G 0.667 N:G[C>T]G 88.333 T:G[C>T]T 14.667 U:G[C>T]T 15.333 B:G[C>T]T 0.0 N:G[C>T]T 48.0 T:G[T>A]A 6.333 U:G[T>A]A 8.667 B:G[T>A]A 0.0 N:G[T>A]A 32.0 T:G[T>A]C 3.0 U:G[T>A]C 3.333 B:G[T>A]C 0.0 N:G[T>A]C 11.0 T:G[T>A]G 18.667 U:G[T>A]G 26.667 B:G[T>A]G 0.333 N:G[T>A]G 62.667 T:G[T>A]T 25.667 U:G[T>A]T 34.333 B:G[T>A]T 0.0 N:G[T>A]T 112.0 T:G[T>C]A 12.333 U:G[T>C]A 14.667 B:G[T>C]A 0.0 N:G[T>C]A 43.333 T:G[T>C]C 11.0 U:G[T>C]C 11.667 B:G[T>C]C 0.0 N:G[T>C]C 34.667 T:G[T>C]G 18.333 U:G[T>C]G 23.333 B:G[T>C]G 0.0 N:G[T>C]G 58.0 T:G[T>C]T 14.667 U:G[T>C]T 19.333 B:G[T>C]T 0.0 N:G[T>C]T 65.333 T:G[T>G]A 2.0 U:G[T>G]A 2.333 B:G[T>G]A 0.0 N:G[T>G]A 9.667 T:G[T>G]C 0.333 U:G[T>G]C 0.667 B:G[T>G]C 0.0 N:G[T>G]C 2.0 T:G[T>G]G 1.667 U:G[T>G]G 4.0 B:G[T>G]G 0.0 N:G[T>G]G 8.0 T:G[T>G]T 30.667 U:G[T>G]T 46.667 B:G[T>G]T 0.333 N:G[T>G]T 117.667 T:T[C>A]A 40.333 U:T[C>A]A 37.667 B:T[C>A]A 0.333 N:T[C>A]A 170.0 T:T[C>A]C 2.333 U:T[C>A]C 2.333 B:T[C>A]C 0.0 N:T[C>A]C 11.667 T:T[C>A]G 0.667 U:T[C>A]G 1.0 B:T[C>A]G 0.0 N:T[C>A]G 3.667 T:T[C>A]T 27.0 U:T[C>A]T 27.667 B:T[C>A]T 0.0 N:T[C>A]T 114.667 T:T[C>G]A 1.333 U:T[C>G]A 2.0 B:T[C>G]A 0.0 N:T[C>G]A 11.667 T:T[C>G]C 2.667 U:T[C>G]C 3.0 B:T[C>G]C 0.0 N:T[C>G]C 12.667 T:T[C>G]G 1.0 U:T[C>G]G 0.667 B:T[C>G]G 0.0 N:T[C>G]G 3.333 T:T[C>G]T 22.333 U:T[C>G]T 35.667 B:T[C>G]T 0.0 N:T[C>G]T 104.333 T:T[C>T]A 28.333 U:T[C>T]A 31.0 B:T[C>T]A 0.333 N:T[C>T]A 108.333 T:T[C>T]C 72.667 U:T[C>T]C 89.333 B:T[C>T]C 1.0 N:T[C>T]C 257.333 T:T[C>T]G 20.333 U:T[C>T]G 21.667 B:T[C>T]G 0.0 N:T[C>T]G 47.667 T:T[C>T]T 99.333 U:T[C>T]T 125.333 B:T[C>T]T 1.333 N:T[C>T]T 395.0 T:T[T>A]A 17.333 U:T[T>A]A 22.333 B:T[T>A]A 0.0 N:T[T>A]A 62.333 T:T[T>A]C 20.0 U:T[T>A]C 24.0 B:T[T>A]C 0.0 N:T[T>A]C 93.0 T:T[T>A]G 10.667 U:T[T>A]G 14.333 B:T[T>A]G 0.0 N:T[T>A]G 64.333 T:T[T>A]T 198.667 U:T[T>A]T 237.0 B:T[T>A]T 2.667 N:T[T>A]T 582.0 T:T[T>C]A 14.667 U:T[T>C]A 14.0 B:T[T>C]A 0.0 N:T[T>C]A 58.333 T:T[T>C]C 136.333 U:T[T>C]C 160.333 B:T[T>C]C 1.667 N:T[T>C]C 426.333 T:T[T>C]G 9.333 U:T[T>C]G 9.667 B:T[T>C]G 0.0 N:T[T>C]G 41.0 T:T[T>C]T 725.333 U:T[T>C]T 1021.667 B:T[T>C]T 13.333 N:T[T>C]T 2418.0 T:T[T>G]A 7.333 U:T[T>G]A 6.667 B:T[T>G]A 0.0 N:T[T>G]A 41.0 T:T[T>G]C 5.333 U:T[T>G]C 6.0 B:T[T>G]C 0.0 N:T[T>G]C 30.0 T:T[T>G]G 52.667 U:T[T>G]G 68.333 B:T[T>G]G 0.0 N:T[T>G]G 128.333 T:T[T>G]T 457.0 U:T[T>G]T 651.333 B:T[T>G]T 7.667 N:T[T>G]T 1483.667 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type genic_real_count intergenic_real_count genic_mean_sims_count intergenic_mean_sims_count genic_versus_intergenic_p_value genic_versus_intergenic_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Transcribed_real_count Transcribed_mean_sims_count Transcribed_min_sims_count Transcribed_max_sims_count Transcribed_sims_count_list UnTranscribed_real_count UnTranscribed_mean_sims_count UnTranscribed_min_sims_count UnTranscribed_max_sims_count UnTranscribed_sims_count_list NonTranscribed_real_count NonTranscribed_mean_sims_count NonTranscribed_min_sims_count NonTranscribed_max_sims_count NonTranscribed_sims_count_list Eye-Melanoma SBS57 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2573.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eye-Melanoma SBS57 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2573.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eye-Melanoma SBS57 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2573.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eye-Melanoma SBS57 T>A 42.0 192.0 36.4 197.96 0.5353387196836741 0.9654358915659855 9.094 2573.0 Intergenic 4.571 5.438 0.841 22.0 15.29 5.0 23.0 [13, 18, 17, 16, 18, 16, 9, 15, 11, 20, 13, 15, 11, 20, 16, 12, 10, 14, 14, 5, 11, 22, 14, 19, 18, 10, 21, 12, 12, 14, 21, 23, 13, 11, 19, 10, 17, 15, 17, 12, 16, 20, 16, 12, 20, 14, 17, 15, 14, 21, 16, 13, 15, 21, 21, 15, 11, 17, 15, 16, 20, 11, 16, 13, 16, 16, 18, 19, 21, 17, 14, 17, 22, 9, 15, 23, 12, 11, 8, 11, 21, 20, 16, 13, 13, 12, 14, 12, 15, 12, 18, 14, 19, 14, 14, 13, 13, 15, 18, 15] 20.0 21.11 12.0 32.0 [19, 18, 20, 26, 18, 31, 16, 15, 19, 20, 26, 22, 32, 16, 18, 17, 18, 24, 26, 20, 15, 18, 24, 21, 23, 23, 21, 27, 25, 24, 23, 23, 12, 18, 21, 26, 20, 24, 20, 27, 17, 24, 20, 23, 20, 32, 24, 13, 23, 19, 22, 17, 25, 22, 25, 19, 32, 21, 24, 21, 17, 19, 16, 22, 19, 16, 24, 16, 15, 31, 18, 20, 17, 16, 23, 14, 22, 25, 18, 12, 23, 24, 17, 20, 24, 17, 23, 23, 22, 21, 24, 25, 22, 21, 19, 21, 21, 19, 22, 24] 192.0 197.96 187.0 212.0 [202, 198, 197, 193, 199, 188, 209, 204, 204, 195, 195, 197, 191, 198, 200, 206, 207, 198, 194, 210, 208, 194, 196, 194, 194, 201, 193, 195, 197, 196, 191, 188, 209, 205, 196, 199, 197, 195, 198, 195, 201, 190, 198, 199, 194, 190, 194, 206, 197, 194, 196, 204, 194, 192, 189, 200, 191, 196, 195, 198, 197, 204, 203, 200, 200, 202, 193, 199, 198, 187, 202, 197, 196, 209, 197, 197, 201, 198, 208, 212, 190, 191, 201, 202, 197, 205, 197, 199, 197, 201, 192, 195, 193, 199, 201, 201, 200, 200, 195, 196] Eye-Melanoma SBS57 T>C 320.0 1235.0 240.28 1313.22 0.0002231874534657379 0.000987178634683485 60.435 2573.0 Intergenic 3.859 5.465 0.706 164.0 101.56 80.0 123.0 [103, 84, 114, 86, 117, 93, 108, 83, 98, 94, 92, 99, 91, 105, 121, 92, 118, 97, 85, 102, 95, 92, 104, 108, 97, 123, 87, 100, 121, 97, 111, 91, 108, 106, 109, 88, 108, 112, 115, 94, 96, 111, 102, 104, 109, 112, 107, 92, 107, 97, 112, 98, 101, 82, 95, 84, 92, 110, 101, 119, 93, 115, 110, 102, 112, 88, 84, 107, 118, 93, 102, 105, 107, 90, 107, 91, 99, 106, 109, 91, 110, 80, 90, 95, 96, 104, 110, 107, 100, 108, 118, 116, 100, 89, 111, 99, 93, 116, 110, 96] 156.0 138.72 117.0 158.0 [146, 129, 140, 135, 136, 137, 134, 142, 136, 137, 134, 136, 142, 152, 132, 121, 149, 152, 141, 140, 141, 151, 136, 137, 147, 122, 138, 131, 130, 136, 150, 137, 129, 144, 142, 129, 149, 129, 133, 143, 155, 138, 126, 136, 151, 139, 146, 148, 131, 134, 157, 141, 147, 148, 155, 150, 125, 132, 158, 133, 128, 130, 124, 136, 125, 153, 135, 136, 145, 134, 151, 138, 137, 132, 156, 129, 139, 125, 127, 156, 126, 144, 137, 133, 130, 149, 152, 127, 144, 147, 131, 138, 138, 136, 153, 117, 155, 145, 142, 117] 1235.0 1313.22 1285.0 1342.0 [1303, 1342, 1299, 1335, 1300, 1323, 1311, 1328, 1320, 1328, 1328, 1317, 1321, 1297, 1302, 1341, 1286, 1305, 1325, 1311, 1316, 1309, 1314, 1311, 1311, 1311, 1327, 1323, 1302, 1320, 1294, 1325, 1319, 1304, 1303, 1335, 1295, 1313, 1305, 1319, 1300, 1304, 1325, 1313, 1292, 1304, 1299, 1313, 1316, 1322, 1285, 1313, 1303, 1323, 1304, 1319, 1335, 1310, 1292, 1303, 1330, 1309, 1320, 1315, 1317, 1310, 1333, 1308, 1293, 1327, 1300, 1313, 1310, 1332, 1291, 1335, 1314, 1320, 1321, 1306, 1316, 1329, 1327, 1325, 1327, 1301, 1292, 1318, 1310, 1298, 1305, 1298, 1318, 1329, 1294, 1335, 1304, 1294, 1303, 1342] Eye-Melanoma SBS57 T>G 121.0 663.0 117.4 667.02 0.8328146342688356 1.0 30.47 2573.0 Intergenic 5.479 5.682 0.964 51.0 48.84 30.0 62.0 [46, 55, 44, 52, 45, 53, 48, 60, 49, 55, 36, 57, 46, 54, 40, 48, 55, 52, 55, 51, 47, 49, 36, 46, 45, 40, 52, 50, 49, 55, 37, 42, 54, 51, 46, 44, 56, 62, 45, 52, 56, 53, 52, 48, 53, 34, 60, 48, 50, 55, 39, 45, 54, 46, 51, 52, 48, 56, 52, 57, 44, 40, 48, 50, 45, 48, 47, 50, 41, 46, 41, 53, 46, 53, 45, 45, 50, 44, 42, 44, 45, 60, 36, 41, 51, 55, 61, 53, 46, 52, 51, 54, 30, 45, 50, 57, 50, 52, 50, 55] 70.0 68.56 50.0 87.0 [70, 79, 72, 70, 66, 50, 64, 83, 54, 56, 70, 69, 70, 81, 76, 58, 75, 50, 73, 75, 79, 59, 62, 60, 64, 83, 72, 62, 52, 73, 79, 64, 67, 62, 65, 66, 65, 61, 87, 67, 65, 62, 63, 60, 79, 56, 71, 57, 78, 56, 71, 75, 62, 71, 62, 80, 74, 79, 69, 71, 82, 77, 62, 77, 84, 60, 78, 71, 64, 74, 60, 59, 68, 65, 75, 73, 79, 81, 70, 65, 61, 64, 63, 71, 70, 59, 70, 59, 83, 84, 68, 85, 75, 60, 67, 57, 62, 80, 63, 60] 663.0 667.02 644.0 693.0 [668, 650, 667, 665, 673, 680, 672, 644, 681, 674, 678, 660, 667, 648, 669, 677, 657, 682, 656, 657, 658, 677, 686, 677, 674, 660, 662, 673, 683, 656, 667, 678, 663, 671, 672, 675, 664, 661, 651, 666, 664, 670, 668, 677, 653, 693, 655, 679, 655, 673, 674, 666, 671, 667, 674, 652, 662, 651, 665, 656, 658, 669, 673, 656, 656, 676, 659, 664, 679, 664, 683, 671, 671, 666, 665, 665, 657, 661, 672, 675, 679, 660, 685, 672, 667, 670, 656, 673, 655, 648, 665, 647, 679, 679, 667, 670, 671, 655, 672, 668] Kidney-RCC SBS57 C>A 43.0 120.0 69.66 94.16 0.003458250605513767 0.013411698727834962 5.153 3163.0 Intergenic 2.791 1.352 2.065 1 1 1 1 1 1 29.0 36.45 23.0 46.0 [39, 37, 41, 38, 37, 33, 41, 23, 46, 45, 35, 45, 33, 36, 38, 38, 33, 39, 37, 33, 29, 33, 36, 36, 36, 33, 39, 34, 46, 40, 36, 40, 34, 25, 30, 37, 35, 36, 42, 35, 42, 43, 38, 29, 40, 36, 34, 39, 38, 33, 33, 31, 35, 45, 34, 29, 29, 39, 45, 44, 31, 36, 40, 37, 34, 41, 33, 32, 40, 32, 40, 34, 34, 30, 35, 40, 29, 38, 37, 28, 45, 36, 38, 38, 34, 38, 38, 39, 42, 39, 36, 31, 42, 32, 36, 40, 38, 34, 34, 39] 14.0 33.21 21.0 45.0 [41, 44, 39, 33, 24, 31, 31, 30, 34, 35, 32, 36, 27, 29, 42, 35, 27, 28, 32, 30, 41, 40, 40, 34, 23, 36, 30, 28, 34, 31, 41, 31, 37, 35, 38, 39, 40, 38, 33, 27, 29, 34, 37, 35, 31, 25, 37, 30, 23, 39, 35, 35, 34, 29, 36, 29, 34, 33, 35, 35, 35, 34, 30, 24, 37, 35, 38, 42, 31, 29, 32, 32, 45, 35, 28, 36, 40, 36, 41, 33, 30, 32, 34, 34, 31, 21, 33, 30, 28, 30, 23, 38, 27, 35, 43, 26, 28, 33, 30, 31] 120.0 94.16 82.0 110.0 [84, 83, 83, 92, 102, 100, 93, 110, 83, 83, 96, 82, 104, 100, 84, 90, 104, 96, 96, 101, 95, 91, 87, 93, 105, 95, 94, 102, 84, 93, 88, 95, 93, 103, 96, 88, 90, 90, 89, 101, 93, 89, 89, 100, 92, 103, 92, 95, 103, 91, 95, 99, 94, 89, 94, 106, 102, 91, 83, 84, 97, 93, 93, 103, 93, 90, 92, 90, 92, 103, 92, 99, 86, 99, 100, 89, 96, 90, 86, 103, 89, 95, 91, 92, 98, 106, 93, 94, 93, 96, 105, 95, 94, 97, 86, 98, 97, 97, 99, 93] Kidney-RCC SBS57 C>G 47.0 73.0 52.56 68.05 0.6000445903491081 1.0 3.794 3163.0 Intergenic 1.553 1.295 1.2 1 1 25.0 26.93 14.0 38.0 [30, 36, 28, 28, 24, 22, 27, 25, 23, 33, 30, 29, 16, 20, 33, 27, 30, 27, 32, 26, 27, 24, 34, 22, 32, 27, 26, 26, 28, 20, 32, 37, 29, 32, 24, 32, 26, 26, 25, 27, 20, 26, 28, 31, 28, 24, 34, 14, 27, 24, 20, 34, 27, 22, 28, 22, 17, 28, 25, 26, 24, 26, 36, 19, 29, 24, 21, 30, 25, 22, 22, 28, 30, 31, 17, 27, 35, 26, 38, 24, 28, 33, 25, 25, 24, 23, 31, 31, 35, 27, 22, 24, 28, 27, 31, 25, 24, 27, 33, 29] 22.0 25.63 13.0 37.0 [22, 25, 21, 23, 27, 30, 25, 27, 27, 20, 21, 28, 29, 22, 25, 24, 33, 37, 26, 27, 16, 28, 28, 18, 30, 30, 30, 24, 31, 31, 22, 24, 26, 20, 25, 29, 27, 23, 24, 30, 24, 28, 34, 19, 28, 23, 26, 34, 21, 25, 19, 28, 24, 23, 19, 25, 31, 23, 24, 29, 32, 21, 13, 29, 21, 30, 23, 25, 31, 29, 31, 22, 16, 20, 27, 23, 23, 23, 29, 26, 26, 29, 16, 31, 30, 27, 31, 31, 24, 24, 24, 27, 26, 26, 30, 25, 23, 23, 23, 31] 73.0 68.05 53.0 81.0 [68, 62, 72, 70, 70, 68, 68, 68, 70, 67, 70, 63, 76, 79, 62, 69, 60, 58, 62, 69, 77, 68, 58, 80, 59, 64, 64, 70, 62, 69, 67, 60, 65, 68, 71, 59, 67, 71, 72, 63, 78, 66, 59, 72, 64, 74, 60, 72, 74, 71, 81, 59, 70, 75, 74, 74, 73, 71, 71, 65, 65, 73, 72, 72, 70, 66, 76, 66, 64, 70, 67, 70, 75, 69, 76, 71, 63, 71, 53, 71, 67, 62, 80, 64, 68, 72, 58, 60, 61, 69, 74, 69, 66, 68, 62, 70, 73, 70, 64, 60] Kidney-RCC SBS57 C>T 126.0 252.0 166.89 212.01 0.0035435180296702 0.013732955162312389 11.951 3163.0 Intergenic 2.0 1.27 1.574 1 1 1 1 69.0 85.15 66.0 105.0 [80, 81, 92, 83, 70, 96, 90, 78, 82, 83, 66, 87, 78, 96, 92, 92, 82, 71, 78, 81, 88, 83, 97, 76, 72, 95, 92, 71, 89, 73, 71, 86, 87, 78, 79, 86, 102, 87, 90, 85, 85, 101, 92, 75, 89, 85, 100, 88, 75, 83, 89, 88, 88, 95, 82, 78, 105, 77, 82, 79, 79, 84, 67, 105, 79, 84, 85, 92, 92, 76, 96, 103, 82, 81, 79, 77, 84, 80, 103, 91, 80, 78, 93, 79, 89, 92, 84, 79, 99, 77, 81, 92, 99, 92, 67, 85, 85, 96, 79, 89] 57.0 81.74 59.0 101.0 [91, 79, 90, 83, 92, 85, 72, 83, 87, 77, 94, 86, 83, 78, 82, 81, 96, 92, 99, 74, 76, 70, 72, 80, 96, 73, 83, 94, 81, 75, 97, 86, 81, 90, 80, 89, 75, 66, 81, 74, 101, 68, 75, 81, 79, 78, 69, 75, 77, 76, 79, 74, 88, 59, 76, 66, 79, 73, 78, 90, 82, 63, 93, 71, 87, 94, 99, 83, 86, 89, 71, 75, 80, 86, 78, 83, 82, 82, 88, 83, 80, 77, 78, 88, 87, 79, 77, 89, 86, 75, 83, 71, 78, 84, 101, 95, 88, 83, 82, 74] 252.0 212.01 190.0 233.0 [209, 218, 198, 213, 216, 198, 217, 218, 210, 221, 218, 208, 216, 206, 207, 207, 201, 215, 200, 223, 214, 224, 208, 223, 210, 212, 209, 214, 209, 229, 211, 208, 210, 210, 220, 204, 201, 227, 207, 220, 196, 210, 212, 222, 211, 214, 210, 217, 227, 218, 213, 219, 203, 224, 220, 233, 196, 227, 220, 208, 220, 233, 218, 204, 211, 202, 195, 205, 201, 212, 214, 201, 218, 211, 221, 220, 212, 218, 190, 204, 217, 222, 206, 212, 202, 208, 218, 210, 193, 227, 213, 217, 205, 201, 213, 198, 206, 199, 219, 216] Kidney-RCC SBS57 T>A 96.0 160.0 108.95 147.17 0.2790800454310008 0.6340739029786369 8.094 3163.0 Intergenic 1.667 1.351 1.234 1 1 42.0 52.55 36.0 69.0 [50, 67, 61, 44, 52, 55, 55, 55, 46, 57, 61, 51, 59, 52, 41, 53, 44, 60, 41, 54, 46, 56, 55, 59, 57, 46, 46, 55, 59, 52, 54, 44, 62, 55, 60, 59, 48, 61, 46, 44, 51, 59, 42, 41, 53, 51, 54, 63, 55, 55, 48, 56, 57, 45, 48, 54, 46, 36, 49, 50, 55, 57, 51, 51, 59, 52, 60, 55, 45, 45, 44, 55, 45, 50, 52, 51, 63, 44, 61, 50, 59, 56, 51, 62, 41, 58, 47, 52, 53, 52, 54, 62, 53, 51, 38, 50, 69, 59, 53, 55] 54.0 56.4 41.0 74.0 [56, 54, 59, 49, 62, 52, 57, 63, 64, 54, 50, 60, 61, 56, 55, 58, 49, 48, 63, 46, 62, 63, 71, 59, 47, 58, 67, 46, 46, 50, 63, 54, 52, 56, 60, 57, 66, 48, 72, 70, 50, 56, 69, 48, 56, 60, 55, 47, 53, 52, 61, 56, 53, 60, 52, 48, 54, 72, 48, 51, 57, 57, 54, 57, 56, 54, 55, 61, 53, 57, 66, 53, 55, 43, 56, 47, 48, 74, 64, 64, 47, 64, 64, 51, 57, 61, 66, 64, 65, 48, 44, 64, 51, 58, 53, 48, 41, 64, 46, 69] 160.0 147.17 131.0 166.0 [151, 135, 135, 163, 144, 150, 144, 138, 145, 148, 145, 144, 137, 147, 159, 145, 162, 147, 151, 155, 148, 136, 131, 141, 151, 152, 144, 154, 152, 156, 138, 159, 142, 145, 137, 139, 141, 148, 137, 143, 158, 142, 146, 166, 146, 144, 148, 146, 147, 148, 147, 144, 146, 150, 156, 153, 156, 149, 159, 155, 144, 143, 151, 148, 140, 149, 140, 141, 159, 153, 147, 147, 156, 162, 149, 158, 144, 138, 131, 141, 151, 137, 140, 144, 159, 138, 143, 141, 139, 156, 157, 131, 153, 147, 166, 158, 146, 133, 157, 135] Kidney-RCC SBS57 T>C 577.0 798.0 593.54 784.19 0.5632204758560753 0.9886540226234088 43.471 3163.0 Intergenic 1.383 1.321 1.047 263.0 267.4 239.0 302.0 [254, 276, 269, 247, 258, 286, 270, 266, 293, 278, 270, 269, 271, 276, 256, 272, 258, 247, 266, 279, 253, 302, 298, 296, 281, 265, 281, 265, 252, 273, 289, 260, 250, 255, 274, 244, 261, 270, 283, 285, 264, 254, 275, 252, 280, 243, 271, 252, 245, 267, 246, 275, 276, 274, 267, 275, 286, 242, 254, 267, 274, 271, 284, 282, 260, 261, 274, 242, 255, 274, 275, 276, 274, 276, 263, 283, 255, 249, 253, 261, 272, 257, 265, 261, 275, 239, 271, 278, 283, 285, 272, 257, 270, 279, 269, 263, 254, 248, 269, 268] 314.0 326.14 293.0 355.0 [324, 310, 306, 332, 322, 321, 299, 328, 308, 302, 348, 344, 304, 315, 327, 336, 347, 306, 325, 349, 315, 309, 311, 304, 323, 338, 318, 331, 310, 328, 325, 293, 325, 328, 333, 322, 330, 321, 303, 327, 332, 333, 300, 337, 306, 324, 353, 324, 311, 327, 317, 325, 322, 336, 335, 311, 335, 325, 319, 336, 333, 321, 349, 348, 316, 348, 337, 343, 319, 299, 334, 335, 344, 319, 350, 319, 328, 320, 349, 345, 350, 338, 312, 341, 339, 310, 323, 306, 324, 316, 331, 332, 330, 315, 333, 350, 321, 355, 345, 332] 798.0 784.19 746.0 828.0 [798, 790, 801, 799, 797, 772, 808, 785, 773, 798, 761, 766, 802, 790, 796, 774, 772, 826, 784, 753, 808, 769, 770, 776, 777, 776, 778, 783, 816, 778, 767, 824, 801, 796, 771, 813, 784, 785, 790, 767, 780, 793, 804, 785, 792, 812, 757, 803, 821, 781, 813, 776, 778, 765, 774, 789, 757, 810, 804, 774, 772, 783, 746, 748, 800, 765, 768, 791, 804, 805, 770, 764, 769, 782, 761, 772, 793, 805, 773, 773, 756, 785, 802, 776, 766, 828, 784, 793, 769, 785, 779, 788, 777, 782, 774, 766, 803, 774, 769, 777] Kidney-RCC SBS57 T>G 395.0 476.0 374.15 498.65 0.31121757070379225 0.6852633455134897 27.537 3163.0 Intergenic 1.205 1.333 0.904 157.0 165.64 129.0 200.0 [168, 180, 158, 162, 153, 160, 163, 166, 147, 176, 167, 200, 176, 172, 169, 186, 165, 175, 174, 157, 167, 152, 167, 168, 153, 175, 168, 167, 165, 167, 160, 155, 167, 198, 159, 160, 159, 159, 171, 167, 167, 191, 165, 169, 162, 169, 152, 183, 161, 161, 142, 156, 171, 172, 158, 156, 155, 163, 152, 157, 192, 134, 148, 179, 167, 169, 156, 162, 157, 179, 153, 159, 129, 164, 158, 171, 162, 175, 174, 153, 181, 157, 184, 184, 158, 185, 174, 155, 168, 175, 170, 148, 159, 170, 163, 143, 179, 176, 191, 163] 238.0 208.51 172.0 252.0 [218, 193, 209, 196, 210, 218, 203, 217, 225, 215, 212, 233, 207, 215, 178, 184, 221, 201, 204, 209, 191, 220, 228, 206, 200, 208, 207, 188, 223, 218, 226, 199, 207, 194, 213, 206, 204, 200, 213, 209, 218, 206, 207, 194, 194, 209, 220, 206, 231, 206, 208, 234, 220, 207, 175, 216, 205, 217, 234, 214, 196, 205, 219, 205, 189, 199, 200, 210, 172, 205, 252, 241, 219, 190, 209, 185, 213, 220, 216, 220, 197, 224, 199, 198, 210, 207, 207, 198, 211, 208, 233, 211, 201, 215, 190, 208, 199, 195, 199, 227] 476.0 498.65 440.0 543.0 [489, 502, 504, 515, 506, 494, 504, 490, 500, 482, 492, 440, 489, 486, 525, 502, 485, 499, 499, 506, 515, 501, 476, 497, 518, 490, 499, 517, 484, 486, 484, 521, 497, 481, 501, 508, 508, 513, 489, 497, 487, 478, 503, 510, 516, 496, 502, 488, 483, 507, 521, 481, 481, 496, 540, 502, 510, 493, 488, 504, 485, 532, 505, 490, 517, 504, 518, 499, 543, 488, 469, 477, 525, 519, 505, 517, 501, 479, 484, 500, 495, 491, 487, 489, 505, 484, 491, 518, 494, 491, 470, 513, 513, 489, 519, 520, 495, 501, 483, 483] Stomach-AdenoCA SBS57 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9171.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS57 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9171.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS57 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9171.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS57 T>A 96.0 162.0 108.74 150.4 0.32196554466657584 0.702555053152534 2.813 9171.0 Intergenic 1.688 1.383 1.22 1 1 48.0 51.65 34.0 67.0 [59, 46, 42, 57, 56, 51, 48, 47, 53, 42, 38, 52, 48, 56, 52, 57, 46, 51, 50, 46, 44, 66, 55, 51, 55, 48, 55, 59, 62, 34, 49, 49, 45, 49, 49, 54, 47, 50, 58, 51, 51, 58, 57, 59, 58, 59, 48, 52, 49, 58, 53, 49, 48, 59, 49, 60, 56, 63, 49, 40, 47, 41, 49, 60, 51, 54, 48, 67, 58, 52, 50, 58, 46, 48, 49, 51, 58, 56, 52, 52, 50, 56, 63, 54, 51, 45, 48, 48, 44, 52, 58, 44, 56, 45, 38, 59, 48, 54, 47, 56] 48.0 57.09 39.0 79.0 [62, 46, 70, 60, 42, 54, 52, 64, 53, 59, 66, 53, 68, 46, 60, 62, 49, 61, 62, 55, 53, 57, 63, 57, 46, 62, 63, 66, 64, 49, 71, 79, 58, 54, 63, 56, 59, 57, 47, 54, 55, 64, 48, 61, 56, 52, 45, 50, 60, 59, 59, 59, 54, 52, 53, 39, 62, 53, 61, 62, 63, 51, 69, 61, 60, 46, 54, 56, 55, 58, 61, 58, 55, 54, 61, 57, 59, 52, 55, 59, 67, 59, 54, 60, 54, 69, 55, 61, 58, 56, 62, 44, 59, 63, 62, 51, 47, 45, 56, 57] 162.0 150.4 131.0 179.0 [140, 166, 147, 141, 162, 158, 159, 148, 152, 157, 155, 153, 142, 160, 148, 139, 165, 146, 148, 160, 161, 136, 142, 151, 159, 148, 143, 134, 134, 179, 138, 131, 156, 155, 146, 148, 153, 153, 154, 153, 155, 138, 153, 139, 144, 148, 167, 157, 150, 142, 147, 153, 157, 148, 157, 160, 142, 143, 148, 158, 149, 168, 141, 139, 149, 160, 157, 136, 146, 148, 150, 143, 159, 156, 148, 150, 141, 152, 151, 148, 142, 144, 142, 145, 153, 145, 155, 152, 157, 150, 139, 170, 145, 151, 159, 148, 164, 160, 155, 147] Stomach-AdenoCA SBS57 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9171.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS57 T>G 4046.0 4867.0 3831.72 5088.38 0.0010661841073155538 0.004391015523605347 97.187 9171.0 Intergenic 1.203 1.328 0.906 1681.0 1695.7 1611.0 1792.0 [1681, 1662, 1706, 1666, 1670, 1738, 1659, 1662, 1674, 1735, 1790, 1720, 1707, 1651, 1706, 1734, 1655, 1660, 1735, 1677, 1667, 1704, 1708, 1711, 1652, 1673, 1686, 1672, 1726, 1680, 1703, 1709, 1642, 1726, 1679, 1641, 1661, 1716, 1703, 1750, 1696, 1704, 1687, 1693, 1774, 1690, 1706, 1705, 1709, 1726, 1662, 1693, 1725, 1661, 1677, 1691, 1710, 1707, 1752, 1663, 1640, 1637, 1731, 1680, 1714, 1746, 1717, 1738, 1678, 1684, 1655, 1708, 1766, 1649, 1667, 1721, 1697, 1685, 1742, 1684, 1714, 1779, 1713, 1711, 1736, 1649, 1664, 1792, 1749, 1640, 1627, 1663, 1751, 1695, 1721, 1689, 1715, 1636, 1648, 1611] 2365.0 2136.02 2010.0 2231.0 [2174, 2138, 2158, 2149, 2217, 2141, 2162, 2205, 2107, 2141, 2062, 2129, 2161, 2202, 2208, 2120, 2092, 2152, 2105, 2148, 2122, 2201, 2133, 2065, 2157, 2150, 2175, 2152, 2099, 2142, 2173, 2163, 2185, 2071, 2130, 2129, 2160, 2103, 2089, 2166, 2072, 2085, 2106, 2194, 2128, 2141, 2110, 2204, 2130, 2114, 2141, 2141, 2109, 2142, 2143, 2145, 2120, 2109, 2124, 2118, 2049, 2131, 2088, 2129, 2189, 2010, 2185, 2135, 2146, 2133, 2120, 2093, 2098, 2216, 2109, 2078, 2120, 2116, 2099, 2193, 2122, 2139, 2115, 2218, 2136, 2159, 2145, 2054, 2119, 2231, 2108, 2167, 2130, 2099, 2152, 2223, 2118, 2150, 2134, 2134] 4867.0 5088.38 4991.0 5237.0 [5064, 5122, 5064, 5110, 5042, 5036, 5102, 5046, 5134, 5043, 5065, 5068, 5058, 5074, 5007, 5065, 5168, 5100, 5073, 5092, 5121, 5023, 5083, 5152, 5112, 5092, 5064, 5091, 5097, 5087, 5048, 5043, 5090, 5121, 5117, 5158, 5111, 5105, 5124, 5007, 5146, 5121, 5132, 5040, 5020, 5077, 5108, 5009, 5074, 5081, 5105, 5087, 5091, 5113, 5101, 5076, 5096, 5089, 5053, 5140, 5237, 5150, 5105, 5113, 5031, 5155, 5023, 5059, 5101, 5099, 5138, 5124, 5060, 5055, 5145, 5110, 5102, 5123, 5080, 5048, 5091, 5004, 5096, 4991, 5051, 5106, 5109, 5072, 5067, 5048, 5187, 5092, 5039, 5110, 5047, 5016, 5082, 5126, 5131, 5177] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS57 T>C Intergenic [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Eye-Melanoma', 'Kidney-RCC', 'Stomach-AdenoCA'] 3 SBS57 T>G Intergenic [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Eye-Melanoma', 'Kidney-RCC', 'Stomach-AdenoCA'] 3