# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 144.058 E:A[C>A]A 144.547 A:A[C>G]A 2.04 E:A[C>G]A 2.312 A:A[C>T]A 41.773 E:A[C>T]A 46.054 A:A[T>A]A 0.086 E:A[T>A]A 0.092 A:A[T>C]A 92.999 E:A[T>C]A 93.668 A:A[T>G]A 5.111 E:A[T>G]A 4.515 A:A[C>A]C 180.556 E:A[C>A]C 200.11 A:A[C>G]C 1.019 E:A[C>G]C 0.949 A:A[C>T]C 6.688 E:A[C>T]C 6.929 A:A[T>A]C 55.538 E:A[T>A]C 59.003 A:A[T>C]C 60.319 E:A[T>C]C 56.311 A:A[T>G]C 0.0 E:A[T>G]C 0.0 A:A[C>A]G 2.008 E:A[C>A]G 1.797 A:A[C>G]G 1.867 E:A[C>G]G 2.267 A:A[C>T]G 17.919 E:A[C>T]G 18.23 A:A[T>A]G 4.598 E:A[T>A]G 3.755 A:A[T>C]G 62.648 E:A[T>C]G 59.404 A:A[T>G]G 0.098 E:A[T>G]G 0.097 A:A[C>A]T 300.034 E:A[C>A]T 287.278 A:A[C>G]T 0.564 E:A[C>G]T 0.624 A:A[C>T]T 19.998 E:A[C>T]T 19.14 A:A[T>A]T 602.656 E:A[T>A]T 657.742 A:A[T>C]T 93.46 E:A[T>C]T 98.101 A:A[T>G]T 186.748 E:A[T>G]T 168.013 A:C[C>A]A 94.109 E:C[C>A]A 87.086 A:C[C>G]A 0.666 E:C[C>G]A 0.574 A:C[C>T]A 2.387 E:C[C>T]A 2.273 A:C[T>A]A 14.177 E:C[T>A]A 12.525 A:C[T>C]A 38.303 E:C[T>C]A 35.202 A:C[T>G]A 120.046 E:C[T>G]A 124.051 A:C[C>A]C 90.302 E:C[C>A]C 98.175 A:C[C>G]C 0.596 E:C[C>G]C 0.572 A:C[C>T]C 3.938 E:C[C>T]C 3.364 A:C[T>A]C 7.874 E:C[T>A]C 9.494 A:C[T>C]C 25.887 E:C[T>C]C 29.086 A:C[T>G]C 0.004 E:C[T>G]C 0.005 A:C[C>A]G 0.0 E:C[C>A]G 0.0 A:C[C>G]G 0.2 E:C[C>G]G 0.191 A:C[C>T]G 59.596 E:C[C>T]G 57.764 A:C[T>A]G 16.174 E:C[T>A]G 13.79 A:C[T>C]G 4.622 E:C[T>C]G 4.28 A:C[T>G]G 74.577 E:C[T>G]G 62.206 A:C[C>A]T 1183.273 E:C[C>A]T 1128.952 A:C[C>G]T 2.419 E:C[C>G]T 2.664 A:C[C>T]T 4.577 E:C[C>T]T 4.284 A:C[T>A]T 0.117 E:C[T>A]T 0.107 A:C[T>C]T 4.035 E:C[T>C]T 3.572 A:C[T>G]T 0.0 E:C[T>G]T 0.0 A:G[C>A]A 2.976 E:G[C>A]A 2.922 A:G[C>G]A 0.889 E:G[C>G]A 0.814 A:G[C>T]A 0.07 E:G[C>T]A 0.069 A:G[T>A]A 3.738 E:G[T>A]A 3.94 A:G[T>C]A 10.714 E:G[T>C]A 10.236 A:G[T>G]A 0.0 E:G[T>G]A 0.0 A:G[C>A]C 95.722 E:G[C>A]C 103.344 A:G[C>G]C 0.691 E:G[C>G]C 0.752 A:G[C>T]C 4.593 E:G[C>T]C 4.383 A:G[T>A]C 24.956 E:G[T>A]C 30.627 A:G[T>C]C 0.424 E:G[T>C]C 0.358 A:G[T>G]C 0.015 E:G[T>G]C 0.015 A:G[C>A]G 0.078 E:G[C>A]G 0.073 A:G[C>G]G 0.01 E:G[C>G]G 0.011 A:G[C>T]G 26.334 E:G[C>T]G 27.792 A:G[T>A]G 3.293 E:G[T>A]G 4.238 A:G[T>C]G 19.589 E:G[T>C]G 17.192 A:G[T>G]G 0.0 E:G[T>G]G 0.0 A:G[C>A]T 233.002 E:G[C>A]T 205.255 A:G[C>G]T 0.007 E:G[C>G]T 0.008 A:G[C>T]T 8.716 E:G[C>T]T 8.499 A:G[T>A]T 69.931 E:G[T>A]T 73.813 A:G[T>C]T 38.119 E:G[T>C]T 35.242 A:G[T>G]T 7.759 E:G[T>G]T 6.754 A:T[C>A]A 2742.135 E:T[C>A]A 2613.961 A:T[C>G]A 9.6 E:T[C>G]A 8.426 A:T[C>T]A 2.457 E:T[C>T]A 2.189 A:T[T>A]A 262.016 E:T[T>A]A 259.261 A:T[T>C]A 8.965 E:T[T>C]A 8.621 A:T[T>G]A 245.073 E:T[T>G]A 213.128 A:T[C>A]C 146.086 E:T[C>A]C 154.91 A:T[C>G]C 1.631 E:T[C>G]C 1.782 A:T[C>T]C 2.172 E:T[C>T]C 1.975 A:T[T>A]C 9.184 E:T[T>A]C 11.172 A:T[T>C]C 30.232 E:T[T>C]C 27.357 A:T[T>G]C 0.012 E:T[T>G]C 0.009 A:T[C>A]G 58.522 E:T[C>A]G 48.723 A:T[C>G]G 0.339 E:T[C>G]G 0.311 A:T[C>T]G 1.669 E:T[C>T]G 1.444 A:T[T>A]G 90.043 E:T[T>A]G 80.396 A:T[T>C]G 27.317 E:T[T>C]G 24.893 A:T[T>G]G 1.296 E:T[T>G]G 1.41 A:T[C>A]T 5147.538 E:T[C>A]T 4608.763 A:T[C>G]T 4.03 E:T[C>G]T 4.283 A:T[C>T]T 1.38 E:T[C>T]T 1.188 A:T[T>A]T 18.888 E:T[T>A]T 20.036 A:T[T>C]T 8.046 E:T[T>C]T 6.815 A:T[T>G]T 818.89 E:T[T>G]T 763.068 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Panc-AdenoCA SBS56 C>A 10972.0 9071.0 10258.14 10189.13 3.3595952179978987e-20 2.82071215145574e-19 76.728 26122.0 Lagging 1.21 1.007 1.201 1 1 10972.0 10258.14 10097.0 10490.0 [10149, 10186, 10294, 10242, 10296, 10308, 10283, 10176, 10363, 10285, 10327, 10223, 10319, 10237, 10277, 10154, 10163, 10223, 10216, 10295, 10283, 10285, 10284, 10286, 10384, 10281, 10269, 10208, 10259, 10289, 10139, 10207, 10253, 10343, 10306, 10357, 10331, 10217, 10183, 10402, 10248, 10301, 10317, 10169, 10271, 10490, 10240, 10103, 10290, 10267, 10244, 10215, 10336, 10330, 10265, 10214, 10336, 10229, 10251, 10297, 10217, 10235, 10137, 10237, 10237, 10226, 10272, 10231, 10271, 10248, 10331, 10293, 10172, 10224, 10274, 10299, 10223, 10303, 10203, 10309, 10262, 10243, 10273, 10220, 10271, 10366, 10296, 10335, 10216, 10288, 10145, 10215, 10255, 10294, 10219, 10179, 10317, 10223, 10163, 10097] 9071.0 10189.13 9978.0 10340.0 [10234, 10313, 10231, 10198, 10075, 10138, 10188, 10268, 10117, 10152, 10171, 10242, 10144, 10282, 10180, 10243, 10264, 10199, 10131, 10199, 10177, 10104, 10118, 10131, 10073, 10220, 10158, 10173, 10215, 10165, 10287, 10204, 10180, 10131, 10161, 10166, 10087, 10199, 10255, 10106, 10231, 10099, 10061, 10143, 10158, 9978, 10217, 10322, 10174, 10196, 10208, 10208, 10206, 10172, 10235, 10294, 10147, 10262, 10217, 10174, 10186, 10223, 10244, 10142, 10254, 10244, 10149, 10289, 10145, 10254, 10102, 10205, 10187, 10233, 10152, 10183, 10219, 10160, 10340, 10215, 10205, 10167, 10188, 10283, 10126, 10084, 10187, 10069, 10228, 10171, 10285, 10240, 10086, 10206, 10221, 10298, 10105, 10186, 10227, 10244] Panc-AdenoCA SBS56 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 26122.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS56 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 26122.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS56 T>A 1261.0 1319.0 1334.3 1298.17 0.19300566533507574 0.48138535068454885 9.877 26122.0 Leading 1.046 0.973 1.075 1261.0 1334.3 1255.0 1402.0 [1328, 1334, 1354, 1398, 1325, 1255, 1379, 1337, 1348, 1339, 1336, 1402, 1323, 1340, 1307, 1326, 1338, 1358, 1317, 1333, 1321, 1298, 1273, 1344, 1390, 1286, 1345, 1322, 1359, 1353, 1377, 1341, 1318, 1329, 1345, 1342, 1312, 1354, 1317, 1324, 1355, 1309, 1329, 1338, 1353, 1347, 1316, 1303, 1377, 1345, 1352, 1329, 1298, 1372, 1320, 1341, 1313, 1352, 1315, 1333, 1339, 1382, 1298, 1343, 1317, 1319, 1315, 1333, 1295, 1293, 1355, 1283, 1356, 1320, 1358, 1316, 1303, 1317, 1382, 1312, 1353, 1325, 1326, 1300, 1329, 1353, 1354, 1348, 1331, 1338, 1343, 1335, 1355, 1310, 1352, 1354, 1358, 1329, 1365, 1312] 1319.0 1298.17 1214.0 1361.0 [1299, 1306, 1280, 1250, 1293, 1361, 1279, 1289, 1294, 1278, 1286, 1214, 1303, 1276, 1310, 1297, 1279, 1275, 1292, 1276, 1359, 1288, 1348, 1313, 1244, 1334, 1290, 1322, 1282, 1290, 1283, 1293, 1305, 1288, 1281, 1327, 1329, 1269, 1317, 1310, 1272, 1305, 1338, 1299, 1258, 1316, 1297, 1318, 1262, 1310, 1276, 1304, 1332, 1285, 1307, 1285, 1340, 1304, 1333, 1272, 1307, 1243, 1327, 1289, 1296, 1308, 1319, 1319, 1337, 1318, 1266, 1354, 1274, 1310, 1258, 1299, 1341, 1316, 1266, 1341, 1298, 1305, 1318, 1304, 1298, 1295, 1290, 1280, 1318, 1280, 1282, 1302, 1305, 1303, 1268, 1272, 1280, 1296, 1289, 1324] Panc-AdenoCA SBS56 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 26122.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS56 T>G 1929.0 1570.0 1819.76 1747.85 0.0005461737889208462 0.0023160637855889244 13.395 26122.0 Lagging 1.229 1.041 1.18 1 1929.0 1819.76 1749.0 1905.0 [1795, 1812, 1799, 1822, 1811, 1881, 1849, 1790, 1774, 1870, 1842, 1837, 1816, 1805, 1848, 1840, 1791, 1807, 1810, 1830, 1852, 1802, 1828, 1832, 1791, 1805, 1812, 1828, 1774, 1767, 1803, 1816, 1848, 1863, 1803, 1839, 1762, 1831, 1749, 1829, 1846, 1823, 1812, 1824, 1799, 1878, 1805, 1792, 1862, 1820, 1800, 1862, 1761, 1811, 1755, 1822, 1758, 1845, 1784, 1813, 1824, 1817, 1898, 1809, 1825, 1791, 1859, 1833, 1905, 1824, 1841, 1789, 1785, 1797, 1829, 1787, 1834, 1781, 1826, 1782, 1803, 1831, 1778, 1826, 1808, 1820, 1847, 1808, 1803, 1872, 1840, 1884, 1792, 1837, 1860, 1854, 1844, 1833, 1815, 1850] 1570.0 1747.85 1680.0 1833.0 [1768, 1741, 1765, 1741, 1757, 1694, 1719, 1769, 1775, 1724, 1746, 1731, 1741, 1770, 1717, 1710, 1752, 1757, 1720, 1749, 1690, 1757, 1752, 1723, 1777, 1746, 1759, 1723, 1801, 1778, 1785, 1765, 1733, 1698, 1781, 1732, 1833, 1742, 1832, 1745, 1747, 1733, 1768, 1727, 1771, 1712, 1771, 1751, 1710, 1736, 1754, 1732, 1771, 1770, 1772, 1749, 1794, 1735, 1791, 1780, 1782, 1765, 1704, 1745, 1751, 1771, 1716, 1761, 1696, 1749, 1740, 1769, 1775, 1772, 1721, 1770, 1739, 1752, 1684, 1766, 1739, 1753, 1777, 1759, 1746, 1759, 1701, 1735, 1779, 1710, 1735, 1708, 1781, 1768, 1680, 1714, 1725, 1744, 1755, 1717] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS56 C>A Lagging ['Panc-AdenoCA'] 1 ['Panc-AdenoCA'] 1 [] 0 [] 0 [] 0 [] 0 ['Panc-AdenoCA'] 1 SBS56 T>G Lagging ['Panc-AdenoCA'] 1 [] 0 [] 0 [] 0 [] 0 [] 0 ['Panc-AdenoCA'] 1