# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 66.0 E:A[C>A]A 65.939 A:A[C>G]A 20.984 E:A[C>G]A 23.996 A:A[C>T]A 38.046 E:A[C>T]A 39.102 A:A[T>A]A 44.587 E:A[T>A]A 45.392 A:A[T>C]A 30.583 E:A[T>C]A 30.672 A:A[T>G]A 1.556 E:A[T>G]A 1.539 A:A[C>A]C 10.823 E:A[C>A]C 11.275 A:A[C>G]C 0.913 E:A[C>G]C 0.847 A:A[C>T]C 0.906 E:A[C>T]C 0.942 A:A[T>A]C 2.94 E:A[T>A]C 3.027 A:A[T>C]C 0.022 E:A[T>C]C 0.02 A:A[T>G]C 2.74 E:A[T>G]C 2.939 A:A[C>A]G 0.245 E:A[C>A]G 0.176 A:A[C>G]G 2.931 E:A[C>G]G 3.811 A:A[C>T]G 29.08 E:A[C>T]G 29.69 A:A[T>A]G 51.439 E:A[T>A]G 49.769 A:A[T>C]G 16.086 E:A[T>C]G 16.095 A:A[T>G]G 860.863 E:A[T>G]G 874.222 A:A[C>A]T 6.384 E:A[C>A]T 6.257 A:A[C>G]T 6.389 E:A[C>G]T 7.16 A:A[C>T]T 3.01 E:A[C>T]T 2.935 A:A[T>A]T 20.483 E:A[T>A]T 20.949 A:A[T>C]T 50.774 E:A[T>C]T 50.159 A:A[T>G]T 10.453 E:A[T>G]T 10.468 A:C[C>A]A 50.829 E:C[C>A]A 54.444 A:C[C>G]A 15.657 E:C[C>G]A 16.077 A:C[C>T]A 33.211 E:C[C>T]A 34.512 A:C[T>A]A 0.71 E:C[T>A]A 0.766 A:C[T>C]A 20.246 E:C[T>C]A 19.531 A:C[T>G]A 6.684 E:C[T>G]A 6.779 A:C[C>A]C 23.139 E:C[C>A]C 21.457 A:C[C>G]C 9.41 E:C[C>G]C 10.495 A:C[C>T]C 20.631 E:C[C>T]C 21.362 A:C[T>A]C 0.005 E:C[T>A]C 0.005 A:C[T>C]C 61.058 E:C[T>C]C 56.151 A:C[T>G]C 1.473 E:C[T>G]C 1.802 A:C[C>A]G 4.187 E:C[C>A]G 4.036 A:C[C>G]G 1.984 E:C[C>G]G 2.388 A:C[C>T]G 0.314 E:C[C>T]G 0.305 A:C[T>A]G 157.506 E:C[T>A]G 146.679 A:C[T>C]G 6.19 E:C[T>C]G 5.818 A:C[T>G]G 923.134 E:C[T>G]G 923.185 A:C[C>A]T 0.198 E:C[C>A]T 0.192 A:C[C>G]T 12.756 E:C[C>G]T 13.021 A:C[C>T]T 4.118 E:C[C>T]T 3.993 A:C[T>A]T 37.278 E:C[T>A]T 34.468 A:C[T>C]T 3.59 E:C[T>C]T 3.42 A:C[T>G]T 8.216 E:C[T>G]T 7.616 A:G[C>A]A 3.065 E:G[C>A]A 3.807 A:G[C>G]A 4.357 E:G[C>G]A 5.139 A:G[C>T]A 32.238 E:G[C>T]A 34.758 A:G[T>A]A 14.093 E:G[T>A]A 15.084 A:G[T>C]A 17.668 E:G[T>C]A 19.488 A:G[T>G]A 44.017 E:G[T>G]A 42.034 A:G[C>A]C 0.713 E:G[C>A]C 0.717 A:G[C>G]C 7.574 E:G[C>G]C 6.622 A:G[C>T]C 6.21 E:G[C>T]C 6.068 A:G[T>A]C 0.59 E:G[T>A]C 0.784 A:G[T>C]C 18.397 E:G[T>C]C 18.899 A:G[T>G]C 29.327 E:G[T>G]C 26.195 A:G[C>A]G 0.432 E:G[C>A]G 0.359 A:G[C>G]G 48.469 E:G[C>G]G 45.198 A:G[C>T]G 70.676 E:G[C>T]G 74.225 A:G[T>A]G 95.497 E:G[T>A]G 87.197 A:G[T>C]G 47.611 E:G[T>C]G 39.343 A:G[T>G]G 1459.329 E:G[T>G]G 1390.786 A:G[C>A]T 2.391 E:G[C>A]T 2.651 A:G[C>G]T 0.237 E:G[C>G]T 0.235 A:G[C>T]T 22.509 E:G[C>T]T 20.396 A:G[T>A]T 35.669 E:G[T>A]T 33.623 A:G[T>C]T 99.228 E:G[T>C]T 100.22 A:G[T>G]T 16.06 E:G[T>G]T 14.186 A:T[C>A]A 8.394 E:T[C>A]A 7.988 A:T[C>G]A 54.087 E:T[C>G]A 48.012 A:T[C>T]A 0.0 E:T[C>T]A 0.0 A:T[T>A]A 29.088 E:T[T>A]A 27.296 A:T[T>C]A 24.448 E:T[T>C]A 24.046 A:T[T>G]A 29.279 E:T[T>G]A 26.039 A:T[C>A]C 0.0 E:T[C>A]C 0.0 A:T[C>G]C 16.401 E:T[C>G]C 14.849 A:T[C>T]C 28.178 E:T[C>T]C 27.283 A:T[T>A]C 0.251 E:T[T>A]C 0.277 A:T[T>C]C 8.435 E:T[T>C]C 7.976 A:T[T>G]C 25.379 E:T[T>G]C 27.658 A:T[C>A]G 0.456 E:T[C>A]G 0.519 A:T[C>G]G 2.079 E:T[C>G]G 2.019 A:T[C>T]G 29.836 E:T[C>T]G 29.24 A:T[T>A]G 57.989 E:T[T>A]G 55.618 A:T[T>C]G 24.723 E:T[T>C]G 22.776 A:T[T>G]G 648.626 E:T[T>G]G 568.79 A:T[C>A]T 20.266 E:T[C>A]T 18.414 A:T[C>G]T 15.284 E:T[C>G]T 14.262 A:T[C>T]T 246.105 E:T[C>T]T 237.171 A:T[T>A]T 18.866 E:T[T>A]T 17.483 A:T[T>C]T 5.36 E:T[T>C]T 4.951 A:T[T>G]T 284.909 E:T[T>G]T 263.845 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Skin-Melanoma SBS55 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9245.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS55 C>G 49.0 52.0 54.02 52.54 0.7815047397423476 1.0 1.092 9245.0 Leading 1.061 0.973 1.091 49.0 54.02 41.0 66.0 [58, 61, 60, 57, 54, 55, 53, 57, 47, 52, 57, 53, 58, 60, 60, 50, 56, 55, 53, 52, 50, 49, 54, 60, 46, 56, 52, 54, 55, 48, 54, 58, 52, 48, 56, 63, 47, 48, 47, 57, 47, 57, 55, 54, 49, 57, 52, 53, 49, 49, 53, 52, 61, 66, 44, 52, 59, 53, 58, 58, 58, 53, 49, 60, 55, 61, 53, 62, 55, 41, 53, 52, 63, 56, 56, 54, 62, 54, 46, 45, 57, 53, 50, 55, 55, 55, 53, 55, 55, 56, 53, 57, 53, 57, 50, 54, 53, 53, 43, 57] 52.0 52.54 42.0 65.0 [49, 47, 50, 47, 53, 55, 61, 50, 63, 56, 50, 53, 46, 45, 49, 56, 54, 51, 51, 53, 59, 56, 53, 48, 59, 53, 51, 47, 51, 53, 57, 50, 52, 53, 50, 46, 63, 58, 59, 54, 61, 52, 48, 53, 55, 56, 58, 57, 57, 55, 51, 49, 48, 45, 58, 56, 50, 48, 50, 46, 51, 49, 58, 47, 55, 48, 53, 44, 53, 57, 55, 51, 42, 52, 43, 48, 43, 54, 63, 64, 52, 52, 59, 48, 49, 48, 61, 54, 45, 56, 53, 45, 56, 45, 59, 50, 59, 55, 65, 49] Skin-Melanoma SBS55 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9245.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS55 T>A 158.0 125.0 146.79 141.03 0.24103915644215984 0.5671421001359251 3.061 9245.0 Lagging 1.264 1.041 1.214 1 1 158.0 146.79 126.0 169.0 [159, 139, 152, 134, 145, 141, 132, 138, 157, 158, 154, 146, 141, 162, 137, 154, 143, 151, 157, 144, 150, 151, 153, 147, 150, 152, 158, 143, 144, 137, 144, 146, 139, 152, 156, 140, 164, 149, 138, 151, 151, 144, 147, 135, 149, 156, 151, 143, 126, 142, 145, 145, 151, 141, 148, 151, 150, 135, 164, 160, 152, 154, 146, 153, 144, 146, 142, 147, 150, 147, 140, 146, 154, 158, 147, 143, 132, 135, 143, 146, 154, 137, 142, 139, 143, 138, 132, 160, 169, 143, 150, 129, 158, 143, 131, 153, 147, 146, 156, 142] 125.0 141.03 123.0 156.0 [132, 139, 138, 148, 143, 144, 155, 152, 134, 131, 136, 142, 143, 135, 145, 136, 145, 130, 137, 148, 134, 138, 142, 146, 137, 137, 131, 141, 146, 156, 143, 134, 143, 136, 136, 143, 126, 131, 156, 145, 123, 143, 138, 149, 135, 124, 141, 144, 154, 149, 150, 143, 132, 154, 146, 136, 139, 150, 134, 135, 137, 137, 140, 142, 142, 137, 145, 146, 138, 141, 144, 140, 139, 138, 143, 141, 150, 151, 146, 142, 137, 140, 148, 148, 137, 149, 155, 132, 126, 152, 144, 154, 128, 138, 147, 136, 143, 141, 130, 146] Skin-Melanoma SBS55 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 9245.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS55 T>G 4588.0 4273.0 4494.46 4369.07 0.15344910236243886 0.4036858709234192 95.846 9245.0 Lagging 1.074 1.029 1.044 4588.0 4494.46 4355.0 4606.0 [4416, 4470, 4555, 4461, 4480, 4365, 4536, 4585, 4440, 4522, 4525, 4492, 4516, 4512, 4508, 4422, 4469, 4478, 4488, 4587, 4476, 4571, 4520, 4485, 4355, 4538, 4467, 4467, 4479, 4568, 4539, 4529, 4449, 4467, 4447, 4441, 4495, 4522, 4486, 4460, 4536, 4431, 4400, 4440, 4450, 4525, 4554, 4485, 4463, 4452, 4491, 4578, 4429, 4492, 4547, 4559, 4518, 4561, 4530, 4501, 4543, 4441, 4500, 4442, 4392, 4485, 4444, 4485, 4536, 4456, 4499, 4606, 4547, 4547, 4502, 4457, 4586, 4585, 4451, 4585, 4462, 4480, 4546, 4484, 4527, 4444, 4519, 4464, 4483, 4424, 4549, 4490, 4481, 4499, 4485, 4520, 4483, 4464, 4579, 4444] 4273.0 4369.07 4260.0 4505.0 [4432, 4361, 4344, 4410, 4359, 4425, 4353, 4273, 4421, 4371, 4333, 4354, 4336, 4360, 4395, 4465, 4400, 4393, 4367, 4260, 4377, 4287, 4339, 4386, 4505, 4385, 4414, 4379, 4400, 4298, 4375, 4393, 4410, 4348, 4357, 4451, 4375, 4358, 4350, 4381, 4368, 4414, 4431, 4435, 4390, 4362, 4272, 4360, 4388, 4420, 4391, 4319, 4416, 4353, 4300, 4268, 4367, 4312, 4347, 4342, 4388, 4418, 4391, 4438, 4396, 4359, 4401, 4323, 4369, 4480, 4376, 4265, 4339, 4352, 4362, 4411, 4294, 4315, 4395, 4305, 4392, 4347, 4347, 4396, 4339, 4394, 4379, 4361, 4331, 4449, 4302, 4360, 4373, 4362, 4391, 4304, 4416, 4355, 4296, 4401] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change