# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS4 Head-SCC [3041, 3878, 5168, 6961, 9622, 12776, 15261, 18312, 22445, 11045] [0.107, 0.136, 0.181, 0.244, 0.338, 0.449, 0.537, 0.646, 0.794, 1.0] [0.968, 0.997, 0.992, 0.984, 0.975, 0.96, 0.956, 0.952, 0.932, 0.933] 0.097 0.893 0.658 INC 0.5 108696 0.799 SBS4 Lung-AdenoCA [76396, 95913, 112832, 129920, 146003, 172392, 202392, 249283, 315840, 148514] [0.203, 0.254, 0.3, 0.345, 0.389, 0.459, 0.539, 0.669, 0.848, 1.0] [1.0, 0.988, 0.979, 0.971, 0.963, 0.952, 0.938, 0.91, 0.894, 0.899] 0.084 0.797 0.593 INC 0.5 1653153 0.831 SBS4 ESCC [521, 581, 682, 852, 1187, 1499, 1914, 2256, 2876, 1371] [0.147, 0.164, 0.193, 0.241, 0.335, 0.425, 0.543, 0.641, 0.819, 1.0] [0.992, 0.971, 0.958, 0.953, 0.926, 0.888, 0.874, 0.87, 0.846, 0.816] 0.094 0.853 0.655 INC 0.62 13743 0.752 SBS4 Liver-HCC [4219, 4725, 5354, 6173, 7574, 9513, 11778, 15448, 20335, 9810] [0.17, 0.191, 0.216, 0.249, 0.306, 0.385, 0.478, 0.63, 0.826, 1.0] [1.0, 0.955, 0.948, 0.926, 0.908, 0.865, 0.827, 0.802, 0.768, 0.794] 0.089 0.83 0.636 INC 0.67 95162 0.751 SBS4 Lung-SCC [38702, 48155, 57543, 68286, 79211, 95309, 118100, 148644, 199874, 106819] [0.143, 0.177, 0.212, 0.252, 0.293, 0.353, 0.437, 0.555, 0.746, 1.0] [0.998, 0.998, 0.995, 0.993, 0.992, 0.982, 0.972, 0.957, 0.934, 0.927] 0.085 0.857 0.568 INC 0.5 962373 0.782 SBS4 ACROSS_ALL_CANCER_TYPES [0.154, 0.184, 0.22, 0.266, 0.332, 0.414, 0.507, 0.628, 0.807, 1.0] [0.992, 0.982, 0.974, 0.965, 0.953, 0.929, 0.913, 0.898, 0.875, 0.874] 5 0 0 5