# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 13736.965 E:A[C>A]A 14768.372 A:A[C>G]A 2308.189 E:A[C>G]A 2440.524 A:A[C>T]A 1923.857 E:A[C>T]A 2005.724 A:A[T>A]A 2957.825 E:A[T>A]A 3093.474 A:A[T>C]A 1857.568 E:A[T>C]A 1939.079 A:A[T>G]A 318.921 E:A[T>G]A 325.081 A:A[C>A]C 8305.358 E:A[C>A]C 8913.432 A:A[C>G]C 882.294 E:A[C>G]C 938.786 A:A[C>T]C 847.653 E:A[C>T]C 887.918 A:A[T>A]C 796.122 E:A[T>A]C 838.464 A:A[T>C]C 125.404 E:A[T>C]C 131.355 A:A[T>G]C 31.983 E:A[T>G]C 33.674 A:A[C>A]G 3599.778 E:A[C>A]G 3753.65 A:A[C>G]G 505.245 E:A[C>G]G 529.228 A:A[C>T]G 292.216 E:A[C>T]G 293.193 A:A[T>A]G 2991.087 E:A[T>A]G 3034.622 A:A[T>C]G 979.315 E:A[T>C]G 1002.035 A:A[T>G]G 246.011 E:A[T>G]G 247.225 A:A[C>A]T 9378.734 E:A[C>A]T 9862.047 A:A[C>G]T 1163.875 E:A[C>G]T 1155.662 A:A[C>T]T 934.378 E:A[C>T]T 974.152 A:A[T>A]T 1618.302 E:A[T>A]T 1639.02 A:A[T>C]T 278.015 E:A[T>C]T 281.932 A:A[T>G]T 58.061 E:A[T>G]T 56.911 A:C[C>A]A 20302.606 E:C[C>A]A 21805.38 A:C[C>G]A 2234.267 E:C[C>G]A 2355.007 A:C[C>T]A 3812.111 E:C[C>T]A 3896.231 A:C[T>A]A 4306.833 E:C[T>A]A 4515.299 A:C[T>C]A 1519.416 E:C[T>C]A 1578.001 A:C[T>G]A 265.894 E:C[T>G]A 265.125 A:C[C>A]C 17008.048 E:C[C>A]C 18245.799 A:C[C>G]C 1557.915 E:C[C>G]C 1634.292 A:C[C>T]C 2755.147 E:C[C>T]C 2808.179 A:C[T>A]C 2951.66 E:C[T>A]C 3091.904 A:C[T>C]C 526.738 E:C[T>C]C 536.218 A:C[T>G]C 87.944 E:C[T>G]C 89.952 A:C[C>A]G 4418.096 E:C[C>A]G 4556.461 A:C[C>G]G 858.011 E:C[C>G]G 863.089 A:C[C>T]G 590.467 E:C[C>T]G 588.513 A:C[T>A]G 7841.927 E:C[T>A]G 7958.67 A:C[T>C]G 1115.54 E:C[T>C]G 1117.39 A:C[T>G]G 835.801 E:C[T>G]G 844.759 A:C[C>A]T 16503.26 E:C[C>A]T 17141.028 A:C[C>G]T 1810.921 E:C[C>G]T 1812.293 A:C[C>T]T 4313.043 E:C[C>T]T 4354.833 A:C[T>A]T 3992.753 E:C[T>A]T 3962.424 A:C[T>C]T 678.031 E:C[T>C]T 661.687 A:C[T>G]T 308.094 E:C[T>G]T 293.61 A:G[C>A]A 9575.475 E:G[C>A]A 10105.763 A:G[C>G]A 1662.584 E:G[C>G]A 1734.757 A:G[C>T]A 1049.019 E:G[C>T]A 1056.245 A:G[T>A]A 2635.66 E:G[T>A]A 2661.619 A:G[T>C]A 908.767 E:G[T>C]A 905.102 A:G[T>G]A 151.787 E:G[T>G]A 155.427 A:G[C>A]C 8478.726 E:G[C>A]C 8944.168 A:G[C>G]C 1493.845 E:G[C>G]C 1544.865 A:G[C>T]C 857.737 E:G[C>T]C 869.185 A:G[T>A]C 949.765 E:G[T>A]C 969.374 A:G[T>C]C 239.913 E:G[T>C]C 244.005 A:G[T>G]C 63.133 E:G[T>G]C 64.59 A:G[C>A]G 3227.91 E:G[C>A]G 3273.268 A:G[C>G]G 792.314 E:G[C>G]G 810.373 A:G[C>T]G 117.423 E:G[C>T]G 118.399 A:G[T>A]G 3481.471 E:G[T>A]G 3488.336 A:G[T>C]G 575.873 E:G[T>C]G 563.102 A:G[T>G]G 635.735 E:G[T>G]G 629.538 A:G[C>A]T 6570.635 E:G[C>A]T 6617.293 A:G[C>G]T 893.516 E:G[C>G]T 881.516 A:G[C>T]T 922.772 E:G[C>T]T 917.25 A:G[T>A]T 1739.916 E:G[T>A]T 1701.619 A:G[T>C]T 207.9 E:G[T>C]T 203.702 A:G[T>G]T 110.305 E:G[T>G]T 105.979 A:T[C>A]A 11696.738 E:T[C>A]A 12075.789 A:T[C>G]A 1394.431 E:T[C>G]A 1378.97 A:T[C>T]A 1305.719 E:T[C>T]A 1284.304 A:T[T>A]A 3026.927 E:T[T>A]A 3100.557 A:T[T>C]A 687.971 E:T[T>C]A 692.704 A:T[T>G]A 121.917 E:T[T>G]A 118.832 A:T[C>A]C 12625.265 E:T[C>A]C 13078.402 A:T[C>G]C 1841.041 E:T[C>G]C 1808.117 A:T[C>T]C 1782.421 E:T[C>T]C 1746.629 A:T[T>A]C 1280.528 E:T[T>A]C 1294.385 A:T[T>C]C 126.84 E:T[T>C]C 123.636 A:T[T>G]C 25.496 E:T[T>G]C 25.244 A:T[C>A]G 2101.951 E:T[C>A]G 2157.561 A:T[C>G]G 473.987 E:T[C>G]G 474.422 A:T[C>T]G 50.043 E:T[C>T]G 47.184 A:T[T>A]G 2642.832 E:T[T>A]G 2549.088 A:T[T>C]G 458.093 E:T[T>C]G 435.883 A:T[T>G]G 555.11 E:T[T>G]G 537.177 A:T[C>A]T 12541.845 E:T[C>A]T 12670.267 A:T[C>G]T 1391.296 E:T[C>G]T 1315.545 A:T[C>T]T 2317.537 E:T[C>T]T 2210.226 A:T[T>A]T 1824.63 E:T[T>A]T 1799.264 A:T[T>C]T 157.345 E:T[T>C]T 149.005 A:T[T>G]T 126.006 E:T[T>G]T 119.872 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list ESCC SBS4 C>A 5154.0 5196.0 5253.21 5349.06 0.7194052275159327 1.0 84.105 12306.0 Leading 1.008 1.018 0.99 5154.0 5253.21 5082.0 5395.0 [5299, 5366, 5246, 5217, 5262, 5195, 5162, 5139, 5257, 5196, 5224, 5247, 5305, 5323, 5293, 5257, 5240, 5280, 5275, 5286, 5206, 5163, 5209, 5205, 5082, 5338, 5259, 5202, 5348, 5323, 5263, 5237, 5254, 5321, 5218, 5371, 5287, 5257, 5292, 5360, 5325, 5287, 5298, 5260, 5234, 5186, 5235, 5256, 5228, 5177, 5264, 5209, 5210, 5149, 5394, 5316, 5240, 5210, 5395, 5204, 5172, 5321, 5227, 5304, 5248, 5209, 5301, 5302, 5191, 5262, 5280, 5195, 5225, 5249, 5342, 5236, 5205, 5275, 5349, 5261, 5192, 5157, 5198, 5341, 5267, 5182, 5316, 5243, 5312, 5216, 5233, 5181, 5237, 5245, 5297, 5272, 5199, 5314, 5165, 5259] 5196.0 5349.06 5210.0 5494.0 [5287, 5218, 5352, 5374, 5356, 5415, 5449, 5455, 5351, 5363, 5406, 5354, 5326, 5273, 5307, 5310, 5357, 5288, 5362, 5366, 5324, 5429, 5424, 5406, 5494, 5282, 5316, 5374, 5261, 5308, 5294, 5377, 5373, 5358, 5369, 5210, 5313, 5370, 5335, 5261, 5303, 5363, 5295, 5311, 5356, 5385, 5364, 5382, 5366, 5440, 5329, 5378, 5363, 5435, 5232, 5285, 5381, 5440, 5246, 5381, 5421, 5319, 5402, 5302, 5341, 5404, 5263, 5286, 5356, 5346, 5365, 5408, 5362, 5378, 5222, 5357, 5435, 5323, 5256, 5393, 5397, 5428, 5385, 5302, 5353, 5405, 5289, 5352, 5261, 5418, 5330, 5381, 5377, 5325, 5273, 5322, 5423, 5307, 5429, 5328] ESCC SBS4 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 12306.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS4 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 12306.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS4 T>A 976.0 980.0 999.26 990.28 0.8485010157941124 1.0 15.895 12306.0 Leading 1.004 0.991 1.013 976.0 999.26 944.0 1060.0 [988, 991, 1025, 995, 997, 1007, 1043, 1010, 977, 1026, 995, 983, 967, 1048, 988, 969, 984, 982, 951, 992, 1007, 1024, 1035, 975, 986, 977, 982, 987, 1048, 1005, 976, 995, 1051, 1007, 980, 985, 959, 1011, 1031, 1000, 1027, 996, 1007, 987, 1035, 944, 1027, 1038, 997, 1005, 958, 1035, 962, 1004, 983, 979, 971, 1005, 1016, 1017, 1011, 1053, 1025, 961, 994, 985, 980, 1018, 959, 1005, 1022, 953, 1027, 1060, 986, 965, 1000, 1042, 972, 1015, 1003, 998, 970, 1032, 993, 1013, 1029, 989, 1016, 983, 995, 992, 956, 985, 1016, 962, 979, 1020, 1048, 982] 980.0 990.28 938.0 1050.0 [1012, 1003, 979, 984, 1004, 981, 938, 981, 1012, 961, 966, 1000, 1005, 947, 1016, 1017, 992, 995, 1034, 1005, 968, 974, 975, 999, 1014, 1016, 994, 1022, 952, 975, 1012, 992, 950, 975, 1006, 1014, 1014, 987, 946, 1000, 997, 980, 980, 1002, 970, 1050, 970, 960, 997, 975, 1003, 961, 1026, 982, 1012, 1017, 1019, 978, 987, 968, 988, 964, 956, 1030, 990, 1011, 1017, 977, 1028, 983, 983, 1024, 959, 940, 1002, 1020, 971, 959, 991, 989, 987, 996, 1007, 964, 990, 970, 958, 997, 988, 982, 1000, 990, 1038, 1014, 991, 1021, 1001, 969, 940, 992] ESCC SBS4 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 12306.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS4 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 12306.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS4 C>A 33569.0 35469.0 34898.19 35452.22 0.00024743687444096985 0.0010893198745841061 70.655 97711.0 Leading 1.057 1.016 1.04 33569.0 34898.19 34596.0 35175.0 [35131, 34962, 34946, 34982, 34912, 34889, 34623, 34812, 34890, 35056, 34913, 34725, 34960, 35109, 35087, 34994, 34804, 34714, 34917, 34749, 35055, 34993, 34910, 34752, 34912, 35041, 34939, 35080, 34732, 34959, 34886, 34706, 35059, 34963, 35032, 35029, 35099, 34911, 34941, 34923, 34819, 34946, 34846, 34839, 34704, 34839, 34853, 35154, 34830, 34844, 34891, 35057, 35015, 34715, 34729, 35102, 34719, 35065, 34940, 34933, 34596, 34824, 34963, 34809, 34854, 34879, 34819, 34765, 34669, 34788, 34896, 34684, 34905, 34755, 34756, 35025, 34764, 35149, 34941, 34955, 34619, 34693, 34861, 35014, 34721, 34914, 35041, 35125, 34916, 35175, 34847, 34818, 34968, 35021, 34746, 34908, 35034, 34782, 34796, 35087] 35469.0 35452.22 35158.0 35796.0 [35282, 35252, 35485, 35338, 35596, 35405, 35796, 35539, 35423, 35523, 35278, 35601, 35498, 35171, 35340, 35348, 35582, 35679, 35501, 35614, 35230, 35340, 35496, 35662, 35276, 35271, 35422, 35294, 35604, 35378, 35448, 35710, 35348, 35380, 35276, 35376, 35360, 35463, 35398, 35365, 35479, 35361, 35542, 35466, 35655, 35629, 35537, 35158, 35543, 35547, 35342, 35321, 35319, 35590, 35555, 35239, 35578, 35377, 35438, 35384, 35585, 35555, 35335, 35487, 35424, 35401, 35426, 35519, 35712, 35541, 35395, 35641, 35331, 35752, 35753, 35461, 35621, 35213, 35516, 35442, 35652, 35652, 35390, 35371, 35498, 35335, 35376, 35223, 35476, 35211, 35463, 35466, 35403, 35412, 35576, 35467, 35311, 35551, 35542, 35329] Head-SCC SBS4 C>G 2769.0 2790.0 2772.12 2831.45 0.7332886319304046 1.0 5.689 97711.0 Leading 1.008 1.021 0.986 2769.0 2772.12 2660.0 2877.0 [2737, 2704, 2660, 2800, 2734, 2831, 2751, 2740, 2788, 2731, 2814, 2735, 2732, 2772, 2724, 2833, 2825, 2755, 2780, 2811, 2775, 2782, 2775, 2755, 2771, 2790, 2770, 2848, 2868, 2806, 2751, 2801, 2748, 2754, 2779, 2794, 2726, 2828, 2717, 2761, 2776, 2763, 2785, 2817, 2735, 2763, 2759, 2743, 2766, 2780, 2772, 2828, 2762, 2813, 2754, 2778, 2725, 2768, 2779, 2787, 2750, 2807, 2691, 2801, 2738, 2789, 2723, 2768, 2757, 2732, 2780, 2771, 2804, 2687, 2799, 2810, 2737, 2754, 2827, 2819, 2680, 2771, 2816, 2754, 2780, 2773, 2806, 2830, 2804, 2877, 2749, 2743, 2790, 2767, 2809, 2777, 2810, 2783, 2694, 2746] 2790.0 2831.45 2729.0 2938.0 [2834, 2893, 2938, 2830, 2900, 2774, 2833, 2856, 2825, 2845, 2784, 2871, 2887, 2846, 2873, 2749, 2775, 2864, 2846, 2775, 2838, 2815, 2812, 2821, 2841, 2800, 2854, 2775, 2749, 2810, 2840, 2805, 2865, 2828, 2827, 2803, 2860, 2775, 2865, 2842, 2843, 2847, 2795, 2761, 2894, 2825, 2816, 2866, 2845, 2816, 2818, 2759, 2844, 2778, 2843, 2831, 2871, 2828, 2839, 2804, 2829, 2757, 2887, 2803, 2894, 2845, 2902, 2849, 2864, 2847, 2847, 2851, 2823, 2890, 2819, 2764, 2861, 2844, 2776, 2780, 2915, 2850, 2784, 2880, 2822, 2853, 2803, 2804, 2796, 2729, 2852, 2883, 2805, 2853, 2831, 2838, 2797, 2809, 2905, 2858] Head-SCC SBS4 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 97711.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS4 T>A 11420.0 11694.0 11836.7 11611.51 0.021000575276015496 0.07154883967267144 23.655 97711.0 Leading 1.024 0.981 1.044 11420.0 11836.7 11635.0 12051.0 [11878, 11879, 11847, 11860, 11853, 11973, 11841, 11944, 11813, 11876, 11900, 11850, 11706, 11847, 11842, 11753, 11917, 11858, 11825, 11947, 11808, 11746, 11905, 11657, 11913, 11823, 11933, 11708, 11868, 11792, 11878, 11875, 11938, 11889, 11756, 11874, 11896, 11745, 11904, 11896, 11753, 11788, 11689, 11844, 11829, 11916, 11792, 11960, 11840, 11800, 11925, 11910, 11791, 11864, 11923, 11771, 11912, 11943, 11752, 12051, 11741, 11781, 11863, 11744, 11837, 11866, 11840, 11714, 11730, 11941, 11739, 11836, 12010, 11855, 11803, 11805, 11793, 11759, 11795, 11713, 11635, 11892, 11891, 11791, 11880, 11829, 11723, 11803, 11824, 11973, 11759, 11785, 11813, 11799, 11905, 11753, 11799, 11896, 11895, 11794] 11694.0 11611.51 11419.0 11785.0 [11629, 11511, 11570, 11617, 11567, 11544, 11680, 11516, 11620, 11613, 11523, 11629, 11713, 11547, 11637, 11651, 11615, 11611, 11593, 11468, 11614, 11667, 11483, 11698, 11578, 11557, 11492, 11670, 11583, 11768, 11489, 11624, 11419, 11564, 11600, 11530, 11586, 11602, 11645, 11623, 11713, 11637, 11774, 11634, 11622, 11582, 11665, 11584, 11640, 11638, 11464, 11561, 11735, 11549, 11552, 11652, 11516, 11533, 11678, 11420, 11700, 11618, 11594, 11618, 11577, 11601, 11605, 11717, 11752, 11540, 11657, 11629, 11517, 11535, 11643, 11700, 11648, 11742, 11664, 11772, 11785, 11510, 11614, 11621, 11630, 11630, 11719, 11602, 11634, 11478, 11612, 11623, 11679, 11744, 11589, 11713, 11657, 11544, 11515, 11628] Head-SCC SBS4 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 97711.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS4 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 97711.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS4 C>A 39017.0 41357.0 40384.8 41310.48 0.00034649379672051087 0.0014968373076217482 92.509 86882.0 Leading 1.06 1.023 1.036 39017.0 40384.8 39953.0 40689.0 [40359, 40491, 40426, 40341, 40028, 40241, 40537, 40266, 40569, 40537, 40216, 40359, 40537, 40166, 40352, 40665, 40251, 40583, 40320, 40383, 40511, 40512, 40275, 40220, 40390, 40281, 40431, 40306, 40439, 40512, 40137, 40297, 40511, 39953, 40174, 40652, 40387, 40383, 40317, 40689, 40251, 40645, 40453, 40270, 40415, 40119, 40428, 40476, 40512, 40398, 40544, 40428, 40323, 40391, 40529, 40484, 40267, 40501, 40577, 40223, 40626, 40444, 40442, 40381, 40156, 40235, 40526, 40394, 40325, 40121, 40313, 40230, 40463, 40343, 40403, 40281, 40284, 40397, 40652, 40529, 40616, 40275, 40263, 40336, 40347, 40540, 40364, 40266, 40417, 40281, 40427, 40413, 40421, 40309, 40399, 40356, 40661, 40287, 40555, 40164] 41357.0 41310.48 40975.0 41771.0 [41468, 41190, 41174, 41269, 41600, 41309, 41085, 41401, 41129, 41121, 41511, 41321, 41273, 41463, 41321, 41011, 41510, 41142, 41421, 41261, 41151, 41176, 41560, 41458, 41320, 41403, 41371, 41415, 41148, 41088, 41507, 41516, 41183, 41771, 41485, 41031, 41338, 41343, 41154, 40975, 41474, 40992, 41241, 41402, 41173, 41526, 41353, 41366, 41099, 41341, 41006, 41259, 41146, 41399, 41198, 41115, 41429, 41289, 41207, 41482, 41113, 41233, 41292, 41374, 41570, 41315, 41218, 41388, 41326, 41504, 41318, 41430, 41307, 41330, 41283, 41381, 41391, 41282, 41185, 41170, 41289, 41578, 41517, 41410, 41298, 41305, 41363, 41367, 41176, 41363, 41256, 41256, 41184, 41444, 41387, 41264, 41083, 41431, 41180, 41617] Liver-HCC SBS4 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 86882.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS4 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 86882.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS4 T>A 3138.0 3370.0 3291.88 3236.17 0.01223540203197953 0.0435777744605738 7.491 86882.0 Leading 1.074 0.983 1.092 3138.0 3291.88 3202.0 3388.0 [3335, 3275, 3299, 3293, 3301, 3259, 3312, 3312, 3310, 3244, 3269, 3308, 3234, 3379, 3350, 3308, 3302, 3238, 3305, 3388, 3291, 3319, 3284, 3264, 3343, 3314, 3340, 3260, 3297, 3313, 3294, 3288, 3342, 3349, 3350, 3281, 3304, 3310, 3256, 3281, 3277, 3281, 3294, 3290, 3285, 3299, 3353, 3205, 3249, 3276, 3306, 3262, 3300, 3317, 3372, 3287, 3218, 3305, 3278, 3261, 3271, 3290, 3260, 3291, 3304, 3203, 3321, 3233, 3259, 3260, 3252, 3325, 3221, 3312, 3281, 3202, 3296, 3291, 3263, 3303, 3297, 3314, 3303, 3338, 3272, 3250, 3336, 3261, 3237, 3312, 3305, 3290, 3379, 3231, 3263, 3341, 3312, 3353, 3320, 3220] 3370.0 3236.17 3130.0 3313.0 [3149, 3302, 3243, 3229, 3217, 3269, 3258, 3238, 3199, 3285, 3284, 3243, 3270, 3146, 3170, 3219, 3228, 3302, 3206, 3150, 3231, 3232, 3249, 3230, 3166, 3223, 3213, 3257, 3252, 3210, 3236, 3234, 3214, 3193, 3186, 3253, 3234, 3213, 3283, 3245, 3218, 3251, 3240, 3252, 3242, 3255, 3171, 3313, 3281, 3213, 3243, 3263, 3236, 3171, 3130, 3243, 3308, 3259, 3243, 3254, 3246, 3222, 3264, 3237, 3196, 3300, 3206, 3271, 3271, 3249, 3279, 3246, 3274, 3242, 3251, 3290, 3245, 3231, 3295, 3264, 3217, 3230, 3216, 3188, 3241, 3253, 3236, 3243, 3273, 3229, 3201, 3253, 3139, 3307, 3252, 3217, 3201, 3176, 3208, 3311] Liver-HCC SBS4 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 86882.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS4 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 86882.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS4 C>A 491591.0 521009.0 508058.53 514616.25 1.109748542169493e-58 1.5037491936519712e-57 66.462 1523570.0 Leading 1.06 1.013 1.046 491591.0 508058.53 506971.0 509615.0 [508175, 507822, 508311, 507388, 507604, 508128, 507682, 508832, 508203, 508330, 507863, 507815, 507595, 507430, 507473, 508815, 508766, 508211, 507715, 507290, 507822, 508982, 508000, 509001, 508365, 508324, 508250, 507996, 507899, 508664, 508781, 508736, 507675, 508401, 508504, 508219, 509007, 508343, 507291, 508034, 507878, 508762, 507653, 508169, 506971, 508036, 508299, 507989, 508583, 507759, 508177, 508281, 508189, 508139, 507516, 508540, 507477, 508089, 507403, 509615, 508498, 507923, 507153, 508228, 507447, 507990, 507770, 508228, 507589, 507703, 509256, 508248, 507270, 507160, 509054, 507231, 508419, 507627, 508423, 508861, 508811, 507662, 507413, 507987, 508155, 507146, 507743, 508136, 507091, 507951, 507588, 508657, 508130, 507105, 507942, 507758, 508830, 508145, 508539, 507719] 521009.0 514616.25 513065.0 515991.0 [514992, 514689, 514335, 515016, 515150, 514597, 515275, 514424, 514805, 514343, 514945, 514791, 515144, 515550, 514858, 513943, 513809, 514332, 515113, 515133, 514787, 513656, 514916, 513311, 514434, 514127, 514248, 514629, 515028, 514377, 514114, 514259, 515042, 513925, 513721, 514436, 513577, 514572, 515726, 514461, 515048, 514089, 514917, 514326, 515732, 514478, 514363, 514755, 513841, 515027, 514467, 514627, 514658, 514724, 515084, 513754, 515527, 514986, 515140, 513252, 514277, 514811, 515819, 513913, 515075, 514620, 514784, 514425, 515498, 515157, 513808, 514036, 515062, 515131, 513646, 515782, 514002, 515253, 514408, 513065, 514013, 514949, 515132, 514765, 514649, 515182, 514686, 514390, 515991, 514656, 515552, 513998, 514454, 515230, 514474, 514452, 514159, 514680, 513642, 514614] Lung-AdenoCA SBS4 C>G 60204.0 62756.0 61529.6 62466.43 0.0010514786352964864 0.0043367737436078805 8.071 1523570.0 Leading 1.042 1.015 1.027 60204.0 61529.6 61078.0 61936.0 [61366, 61511, 61078, 61765, 61566, 61533, 61696, 61535, 61618, 61673, 61622, 61284, 61679, 61334, 61873, 61735, 61548, 61529, 61251, 61679, 61708, 61398, 61720, 61351, 61271, 61753, 61640, 61450, 61598, 61507, 61356, 61348, 61388, 61810, 61466, 61447, 61233, 61099, 61249, 61434, 61638, 61556, 61541, 61682, 61676, 61610, 61449, 61827, 61936, 61382, 61601, 61584, 61527, 61358, 61554, 61473, 61588, 61796, 61691, 61501, 61582, 61406, 61311, 61437, 61856, 61601, 61471, 61504, 61400, 61692, 61626, 61473, 61443, 61867, 61539, 61555, 61396, 61763, 61469, 61480, 61788, 61284, 61684, 61197, 61380, 61785, 61611, 61447, 61386, 61621, 61696, 61251, 61628, 61552, 61497, 61453, 61306, 61813, 61336, 61303] 62756.0 62466.43 62043.0 62897.0 [62585, 62490, 62858, 62323, 62549, 62567, 62360, 62291, 62551, 62284, 62350, 62624, 62353, 62738, 62219, 62304, 62429, 62453, 62703, 62300, 62303, 62670, 62314, 62437, 62897, 62336, 62376, 62423, 62472, 62516, 62780, 62683, 62502, 62289, 62395, 62472, 62727, 62768, 62787, 62465, 62372, 62454, 62532, 62269, 62365, 62289, 62495, 62225, 62043, 62628, 62334, 62376, 62307, 62503, 62367, 62503, 62502, 62279, 62201, 62666, 62414, 62595, 62567, 62581, 62080, 62298, 62701, 62421, 62415, 62355, 62428, 62439, 62578, 62330, 62536, 62498, 62508, 62280, 62496, 62470, 62305, 62692, 62260, 62705, 62550, 62314, 62297, 62508, 62571, 62605, 62332, 62650, 62353, 62602, 62513, 62679, 62710, 62216, 62577, 62561] Lung-AdenoCA SBS4 C>T 45479.0 44759.0 45183.84 45734.91 0.002846064693482175 0.011175600104601134 5.923 1523570.0 Lagging 1.016 0.988 1.028 45479.0 45183.84 44807.0 45548.0 [45206, 45077, 45099, 45227, 44923, 45349, 45330, 45430, 45374, 45080, 45011, 45247, 45128, 45061, 45160, 45056, 45128, 45300, 45430, 45337, 45181, 45187, 44924, 45231, 45137, 45251, 45155, 45054, 44984, 45294, 45177, 45203, 45347, 45132, 45302, 45334, 44931, 45314, 45311, 45210, 45174, 45238, 45148, 45301, 44943, 44807, 44936, 45199, 45025, 45319, 45259, 45111, 45207, 45323, 45100, 44891, 45035, 45202, 45146, 45145, 45453, 45124, 45330, 45348, 45128, 45122, 45165, 45229, 44891, 44863, 45302, 45367, 45260, 45144, 45543, 45143, 45061, 45193, 45140, 45062, 45133, 45173, 45147, 45354, 45209, 45340, 45548, 45200, 45316, 45295, 45155, 44887, 45270, 45024, 45420, 44856, 44957, 45449, 45156, 45506] 44759.0 45734.91 45391.0 46129.0 [45779, 45702, 45862, 45747, 45830, 45570, 45523, 45548, 45651, 45761, 45867, 45774, 45831, 45897, 45696, 45877, 45617, 45520, 45502, 45632, 45763, 45776, 46011, 45709, 45760, 45720, 45718, 45939, 45722, 45431, 45716, 45782, 45528, 45897, 45627, 45607, 45810, 45630, 45593, 45703, 45733, 45722, 45879, 45521, 45925, 46112, 45975, 45790, 45791, 45680, 45592, 46040, 45746, 45550, 45948, 45970, 45896, 45874, 45731, 45673, 45391, 45814, 45554, 45642, 45721, 45961, 45705, 45715, 45824, 45933, 45661, 45558, 45751, 45900, 45451, 45807, 45838, 45681, 45787, 45872, 45800, 45566, 45843, 45501, 45720, 45497, 45484, 45750, 45678, 45565, 45797, 46012, 45719, 45783, 45630, 46129, 45899, 45450, 45800, 45526] Lung-AdenoCA SBS4 T>A 135962.0 139630.0 139943.35 137778.26 4.210310050001428e-15 3.1282520627919883e-14 18.089 1523570.0 Leading 1.027 0.985 1.043 135962.0 139943.35 139255.0 140434.0 [139837, 140069, 140030, 140018, 139562, 140075, 140340, 140287, 139624, 139800, 140102, 140044, 139723, 140012, 140028, 140062, 140084, 140164, 140236, 140120, 140138, 140052, 140165, 140001, 139697, 139782, 139908, 140176, 140137, 139792, 139701, 140248, 139719, 140321, 139936, 139545, 140289, 140045, 140294, 139879, 140267, 139596, 139614, 140214, 140377, 139557, 140164, 139542, 139452, 139625, 139836, 139625, 139255, 139923, 140072, 139959, 139607, 139471, 139991, 140334, 139391, 139875, 140082, 139726, 139570, 139911, 139963, 139933, 139998, 139702, 140294, 140177, 140036, 140205, 139912, 140180, 139757, 139868, 139807, 139283, 140022, 140322, 140434, 139787, 139639, 139837, 140143, 139941, 140068, 140207, 140404, 140328, 140007, 139906, 139633, 139788, 139658, 140180, 139764, 140074] 139630.0 137778.26 137203.0 138586.0 [137939, 137753, 137812, 137755, 138157, 137586, 137384, 137493, 137899, 138043, 137388, 137778, 138162, 137694, 137841, 137712, 137759, 137203, 137475, 137495, 137654, 137828, 137511, 137848, 137930, 138052, 137791, 137669, 137622, 138024, 137956, 137466, 138065, 137362, 137802, 138000, 137420, 137608, 137575, 137733, 137448, 138169, 138106, 137626, 137358, 138036, 137522, 137897, 138135, 137963, 137828, 137888, 138586, 137741, 137614, 137983, 138100, 138063, 137878, 137445, 138275, 137879, 137786, 138092, 138015, 137599, 137919, 137631, 138018, 137995, 137270, 137527, 137463, 137774, 137811, 137418, 138182, 137622, 137784, 138302, 137833, 137480, 137362, 137950, 137958, 138105, 137689, 137773, 137575, 137329, 137452, 137455, 137710, 137776, 138157, 137852, 138045, 137666, 137993, 137674] Lung-AdenoCA SBS4 T>C 5997.0 6174.0 6139.65 6125.22 0.22417043398265588 0.537181949626377 0.799 1523570.0 Leading 1.03 0.998 1.032 5997.0 6139.65 6012.0 6276.0 [6142, 6133, 6117, 6170, 6129, 6130, 6107, 6084, 6148, 6044, 6148, 6219, 6114, 6127, 6055, 6205, 6106, 6187, 6149, 6177, 6276, 6223, 6264, 6056, 6165, 6166, 6180, 6211, 6275, 6184, 6151, 6040, 6023, 6102, 6091, 6165, 6197, 6114, 6219, 6048, 6166, 6095, 6173, 6180, 6162, 6084, 6183, 6198, 6112, 6160, 6190, 6052, 6137, 6135, 6055, 6143, 6156, 6191, 6089, 6205, 6225, 6197, 6096, 6136, 6130, 6140, 6126, 6212, 6156, 6224, 6139, 6012, 6170, 6132, 6159, 6160, 6069, 6165, 6206, 6049, 6174, 6090, 6104, 6098, 6183, 6036, 6097, 6142, 6121, 6118, 6148, 6139, 6089, 6090, 6101, 6014, 6146, 6131, 6160, 6174] 6174.0 6125.22 5970.0 6255.0 [6117, 6095, 6141, 6111, 6107, 6101, 6151, 6191, 6156, 6228, 6152, 6033, 6105, 6107, 6220, 6080, 6165, 6076, 6117, 6086, 5970, 6055, 6032, 6217, 6133, 6108, 6078, 6080, 5997, 6050, 6116, 6236, 6219, 6131, 6175, 6116, 6063, 6120, 6056, 6199, 6061, 6211, 6074, 6038, 6108, 6201, 6102, 6080, 6123, 6131, 6114, 6158, 6224, 6134, 6216, 6138, 6110, 6079, 6177, 6056, 6022, 6056, 6143, 6130, 6144, 6104, 6115, 6090, 6148, 6063, 6131, 6228, 6094, 6106, 6078, 6091, 6183, 6066, 6014, 6255, 6118, 6162, 6173, 6179, 6131, 6217, 6166, 6054, 6190, 6166, 6112, 6112, 6148, 6207, 6238, 6216, 6101, 6135, 6108, 6103] Lung-AdenoCA SBS4 T>G 5056.0 4953.0 5108.97 4992.95 0.9437770852703348 1.0 0.657 1523570.0 Lagging 1.021 1.023 0.998 5056.0 5108.97 4983.0 5244.0 [5070, 5106, 5202, 5145, 5067, 5213, 5128, 5100, 5244, 5036, 5015, 5155, 5117, 5107, 5221, 5060, 5043, 5169, 5161, 5062, 5117, 5134, 5104, 5084, 5190, 5134, 5167, 5103, 5157, 5106, 5149, 5094, 5074, 5131, 5207, 5067, 5058, 5135, 5179, 5108, 5153, 5113, 5149, 5181, 5080, 5073, 5124, 5077, 5096, 5145, 5028, 5154, 5142, 5062, 5061, 5034, 5052, 5116, 5139, 5115, 5071, 5092, 5073, 5183, 5091, 5129, 5085, 5156, 4983, 5073, 5075, 5107, 5105, 5085, 5140, 5103, 5088, 5162, 5084, 5069, 5152, 5106, 5079, 5194, 5021, 5045, 5041, 5147, 5012, 5090, 5043, 5012, 5107, 5197, 5051, 5127, 5167, 5036, 5160, 5143] 4953.0 4992.95 4890.0 5139.0 [5027, 4998, 4892, 4963, 4999, 4890, 4979, 4990, 4896, 5062, 5080, 4896, 4988, 5007, 4921, 5034, 5037, 4942, 4976, 5019, 4994, 4963, 4963, 4995, 4904, 4949, 4948, 5000, 4905, 5014, 4957, 5013, 5065, 4949, 4914, 5034, 5027, 4995, 4944, 4983, 4963, 5011, 4947, 4960, 5007, 5047, 4947, 5037, 5036, 4962, 5050, 4964, 4967, 5025, 5052, 5072, 5056, 4928, 4947, 4980, 5023, 5030, 5043, 4909, 4986, 4992, 4970, 4984, 5112, 4976, 5073, 5036, 4929, 5015, 4986, 5019, 5031, 4965, 4997, 5009, 4940, 4968, 4978, 4914, 5086, 5025, 5093, 4964, 5139, 5005, 5100, 5050, 5047, 4924, 5049, 4998, 4935, 5001, 4945, 4979] Lung-SCC SBS4 C>A 311240.0 329578.0 322468.54 326685.88 3.3748287675807954e-36 3.6636829877454915e-35 72.441 884611.0 Leading 1.059 1.013 1.045 311240.0 322468.54 321642.0 323456.0 [322541, 321864, 322213, 322684, 322270, 322109, 322066, 323045, 322697, 322205, 322399, 322464, 322174, 323028, 322733, 322561, 322035, 322923, 321793, 322865, 322903, 323180, 322321, 322459, 323456, 322100, 322011, 321727, 323289, 322361, 322810, 322291, 322520, 322048, 321938, 322502, 322845, 323225, 322321, 322057, 322271, 322127, 321831, 321998, 322981, 322235, 322568, 323039, 322711, 322660, 322938, 322527, 322762, 322569, 322268, 322350, 322549, 322641, 321852, 322074, 321892, 323287, 321858, 321866, 322870, 322304, 322348, 322623, 322960, 322646, 322696, 322855, 322703, 322187, 322655, 322853, 322495, 322480, 322797, 322322, 322912, 321907, 322001, 322713, 322832, 322377, 321943, 322940, 322589, 322550, 322729, 322124, 322449, 322753, 322529, 321642, 322504, 322049, 322491, 322139] 329578.0 326685.88 325590.0 327712.0 [326612, 327531, 327025, 326486, 327121, 326997, 326897, 325955, 326527, 326680, 326735, 326534, 326879, 326377, 326364, 326543, 327084, 326308, 327290, 326386, 326119, 326178, 326928, 326578, 325590, 327001, 327099, 327239, 326045, 326631, 326490, 327112, 326666, 327001, 326903, 326611, 325860, 326181, 326939, 327195, 327085, 327028, 327407, 326861, 326029, 327178, 326174, 326414, 326082, 326711, 325907, 326879, 326624, 326605, 326767, 326701, 326280, 326266, 327562, 326953, 327163, 325748, 327388, 327067, 326298, 326611, 326827, 326585, 326587, 326085, 326540, 326353, 326262, 327195, 326630, 326394, 326316, 326769, 326492, 326991, 326173, 327031, 327363, 326339, 326506, 326798, 327008, 326315, 326856, 326657, 326609, 327161, 326643, 326397, 326514, 327712, 327072, 327232, 326564, 327127] Lung-SCC SBS4 C>G 20193.0 20966.0 20670.91 21011.06 0.12802193411327326 0.3498007440556337 4.653 884611.0 Leading 1.038 1.016 1.021 20193.0 20670.91 20332.0 20866.0 [20514, 20730, 20591, 20599, 20818, 20656, 20669, 20716, 20765, 20753, 20728, 20798, 20611, 20733, 20453, 20662, 20645, 20628, 20596, 20850, 20511, 20689, 20822, 20681, 20689, 20743, 20805, 20674, 20594, 20434, 20579, 20525, 20607, 20548, 20800, 20770, 20794, 20639, 20800, 20787, 20708, 20332, 20644, 20756, 20716, 20629, 20723, 20600, 20508, 20779, 20546, 20543, 20671, 20764, 20640, 20759, 20828, 20582, 20727, 20570, 20735, 20837, 20526, 20708, 20689, 20717, 20727, 20668, 20613, 20454, 20526, 20513, 20562, 20679, 20812, 20707, 20720, 20604, 20611, 20763, 20866, 20650, 20649, 20864, 20674, 20816, 20694, 20682, 20767, 20529, 20702, 20699, 20648, 20752, 20758, 20710, 20599, 20548, 20601, 20681] 20966.0 21011.06 20769.0 21256.0 [21087, 20976, 21128, 21056, 20846, 20995, 21079, 20846, 20941, 20865, 20914, 20889, 21079, 20984, 21202, 20966, 21063, 20993, 21117, 20884, 21229, 21073, 20769, 20939, 21033, 20911, 20951, 20977, 21084, 21200, 21136, 21101, 21063, 21017, 20835, 20993, 20917, 21075, 20798, 20961, 21007, 21256, 21013, 20962, 20975, 21036, 20999, 20961, 21139, 20932, 21147, 21058, 21001, 21046, 20963, 20928, 20818, 21083, 20977, 21193, 21008, 20864, 21137, 20973, 21013, 20973, 20970, 21009, 21112, 21156, 21177, 21096, 21219, 20951, 20956, 20956, 20979, 21028, 21086, 20926, 20905, 20961, 21045, 20901, 21001, 20878, 20990, 20979, 20936, 21156, 21101, 21045, 20977, 20963, 20963, 20901, 21103, 21215, 21128, 20903] Lung-SCC SBS4 C>T 7099.0 6992.0 7024.34 7158.31 0.15348896072444834 0.4036858709234192 1.593 884611.0 Lagging 1.015 0.981 1.035 7099.0 7024.34 6889.0 7188.0 [6955, 7188, 7025, 6985, 6930, 7076, 6980, 7083, 6972, 7055, 6970, 7039, 7020, 7048, 6963, 6971, 7066, 7025, 7031, 7084, 6991, 7102, 7081, 7085, 7081, 6889, 7099, 6996, 7047, 6919, 6983, 7180, 7100, 6965, 6905, 7017, 7053, 7009, 7045, 7036, 7065, 7141, 6957, 6987, 7051, 7033, 6919, 7029, 7058, 7120, 7085, 7126, 6955, 7012, 6985, 7030, 7078, 6961, 6955, 7118, 7116, 6901, 7110, 6971, 6972, 7014, 7061, 7021, 7066, 6958, 6951, 6952, 7020, 6974, 6966, 7024, 7096, 7045, 7079, 6996, 7071, 7001, 7133, 7079, 7005, 6899, 7018, 7022, 7061, 7076, 7000, 6976, 7001, 7155, 7039, 6915, 6966, 7023, 7044, 6943] 6992.0 7158.31 7014.0 7291.0 [7245, 7040, 7180, 7210, 7233, 7133, 7159, 7048, 7168, 7180, 7220, 7186, 7144, 7163, 7203, 7218, 7117, 7184, 7140, 7075, 7228, 7070, 7072, 7045, 7094, 7262, 7061, 7178, 7124, 7270, 7161, 7014, 7078, 7246, 7262, 7176, 7147, 7112, 7171, 7147, 7105, 7105, 7219, 7234, 7145, 7134, 7260, 7151, 7097, 7056, 7080, 7086, 7217, 7156, 7174, 7167, 7108, 7179, 7155, 7040, 7042, 7258, 7108, 7242, 7231, 7174, 7152, 7210, 7082, 7246, 7233, 7257, 7138, 7202, 7230, 7150, 7132, 7153, 7122, 7211, 7061, 7154, 7078, 7148, 7135, 7254, 7167, 7183, 7153, 7094, 7173, 7282, 7157, 7053, 7169, 7291, 7227, 7138, 7132, 7177] Lung-SCC SBS4 T>A 92295.0 94278.0 94968.52 93461.55 1.1806932242895576e-08 6.895614536277153e-08 21.091 884611.0 Leading 1.021 0.984 1.038 92295.0 94968.52 94525.0 95418.0 [94884, 95133, 94978, 94891, 94694, 95237, 94762, 94696, 94808, 95068, 95302, 94791, 95240, 94893, 94743, 95146, 95106, 94797, 94918, 95203, 94872, 94951, 95225, 94943, 94940, 95060, 94832, 95136, 95232, 95113, 95277, 94880, 94792, 95083, 94862, 94713, 94551, 94935, 95174, 94680, 94833, 94764, 95243, 94616, 95332, 94804, 95259, 94841, 94870, 94876, 94711, 94773, 95029, 94768, 94857, 94978, 95030, 95374, 95220, 95399, 94920, 95236, 94588, 95418, 95188, 94525, 94790, 95243, 94928, 94863, 94759, 95008, 94821, 95179, 95067, 94756, 95291, 95002, 95055, 95149, 95185, 94946, 94715, 94836, 95228, 95002, 95351, 94792, 95025, 94834, 94789, 94865, 94869, 94625, 95143, 95258, 94803, 94615, 95177, 94890] 94278.0 93461.55 93066.0 93995.0 [93652, 93116, 93508, 93674, 93853, 93069, 93762, 93585, 93612, 93445, 93150, 93694, 93228, 93636, 93875, 93256, 93538, 93689, 93387, 93212, 93256, 93440, 93126, 93304, 93720, 93402, 93563, 93386, 93327, 93132, 93198, 93711, 93664, 93385, 93634, 93612, 93704, 93306, 93303, 93801, 93571, 93549, 93222, 93677, 93102, 93487, 93306, 93589, 93499, 93586, 93519, 93542, 93445, 93673, 93612, 93280, 93518, 93100, 93196, 93106, 93605, 93275, 93857, 93066, 93235, 93995, 93485, 93328, 93357, 93594, 93552, 93535, 93551, 93349, 93388, 93575, 93098, 93556, 93201, 93429, 93205, 93458, 93736, 93556, 93268, 93564, 93165, 93595, 93476, 93532, 93603, 93691, 93567, 93864, 93111, 93241, 93600, 93647, 93158, 93593] Lung-SCC SBS4 T>C 237.0 260.0 245.84 250.65 0.6113333423506417 1.0 0.056 884611.0 Leading 1.097 1.02 1.076 237.0 245.84 225.0 284.0 [239, 245, 249, 227, 262, 240, 237, 237, 240, 227, 230, 244, 252, 260, 246, 246, 232, 231, 284, 250, 240, 238, 265, 268, 244, 256, 229, 260, 248, 260, 226, 258, 255, 245, 247, 260, 255, 231, 242, 245, 239, 254, 236, 245, 259, 245, 259, 249, 244, 244, 254, 238, 247, 259, 258, 245, 245, 251, 236, 245, 254, 259, 248, 243, 248, 246, 235, 252, 226, 225, 242, 245, 246, 231, 238, 244, 262, 236, 225, 252, 250, 248, 248, 258, 245, 232, 244, 250, 247, 242, 256, 231, 247, 243, 245, 260, 232, 272, 250, 225] 260.0 250.65 218.0 277.0 [252, 254, 253, 266, 250, 248, 257, 272, 252, 259, 264, 258, 246, 218, 247, 246, 264, 263, 223, 244, 255, 250, 239, 230, 250, 243, 270, 245, 253, 241, 276, 232, 235, 245, 264, 237, 239, 268, 249, 254, 249, 245, 254, 254, 246, 250, 242, 248, 247, 251, 248, 263, 254, 227, 241, 246, 252, 243, 251, 250, 249, 246, 255, 254, 241, 250, 257, 239, 277, 264, 251, 244, 243, 275, 254, 249, 235, 261, 267, 241, 252, 259, 247, 241, 251, 266, 252, 249, 253, 258, 243, 247, 252, 256, 249, 238, 267, 240, 249, 272] Lung-SCC SBS4 T>G 747.0 726.0 748.24 736.05 0.883049567945244 1.0 0.167 884611.0 Lagging 1.029 1.017 1.012 747.0 748.24 704.0 808.0 [754, 729, 750, 769, 788, 736, 798, 718, 776, 732, 754, 726, 742, 754, 750, 739, 755, 753, 735, 763, 796, 808, 732, 754, 769, 779, 741, 755, 755, 776, 748, 714, 769, 779, 741, 761, 742, 709, 754, 777, 760, 758, 723, 754, 727, 744, 757, 768, 723, 779, 774, 748, 743, 728, 771, 748, 735, 744, 756, 782, 761, 757, 746, 704, 759, 778, 705, 734, 760, 771, 727, 752, 775, 733, 731, 738, 710, 719, 709, 747, 752, 721, 716, 765, 730, 749, 766, 736, 706, 758, 730, 727, 720, 742, 783, 747, 747, 742, 736, 733] 726.0 736.05 676.0 789.0 [745, 750, 728, 715, 687, 739, 676, 766, 713, 748, 735, 741, 725, 733, 723, 757, 747, 736, 752, 722, 693, 680, 758, 739, 719, 710, 745, 738, 711, 701, 749, 763, 700, 715, 735, 715, 746, 764, 729, 706, 722, 720, 766, 726, 745, 731, 721, 699, 740, 713, 710, 747, 739, 734, 719, 727, 778, 735, 743, 715, 738, 733, 731, 784, 718, 706, 789, 750, 725, 729, 778, 726, 707, 759, 754, 753, 754, 766, 786, 735, 740, 750, 762, 696, 761, 737, 744, 753, 778, 738, 763, 748, 764, 743, 712, 746, 732, 735, 758, 740] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS4 C>A Leading [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Lung-SCC'] 5 SBS4 C>G Leading [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Lung-SCC'] 5 SBS4 C>T Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Lung-SCC'] 5 SBS4 T>A Leading [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Lung-SCC'] 5