# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
signature	cancer_type	dna_element	encode_element_list	fold_change_list	avg_fold_change	p_value_list	combined_p_value	q_value
SBS4	ESCC	H3K27ac-human	['ENCFF683MJC_esophagus-squamous-epithelium_Normal_H3K27ac-human']	[0.871]	0.871	[7.286541631070643e-08]	7.286541631070633e-08	2.157288598643366e-07
SBS4	ESCC	H3K36me3-human	['ENCFF848QKQ_esophagus-squamous-epithelium_Normal_H3K36me3-human']	[0.974]	0.974	[0.010444590742273743]	0.010444590742273743	0.019908541817240114
SBS4	ESCC	H3K4me1-human	['ENCFF353HXQ_esophagus-squamous-epithelium_Normal_H3K4me1-human']	[0.968]	0.968	[0.008471893593320453]	0.008471893593320448	0.016376148976106075
SBS4	ESCC	H3K4me3-human	['ENCFF518WBH_esophagus-squamous-epithelium_Normal_H3K4me3-human', 'ENCFF565PHW_epithelial-cell-of-esophagus_Normal_H3K4me3-human']	[0.862, 0.903]	0.882	[1.1118979128076588e-06, 0.0018405389349345214]	4.2990929351644436e-08	1.286709796585489e-07
SBS4	ESCC	H3K9me3-human	['ENCFF164KXT_esophagus-squamous-epithelium_Normal_H3K9me3-human']	[0.932]	0.932	[0.0023227939091730035]	0.0023227939091730026	0.004854335636980834
SBS4	Head-SCC	H3K27ac-human	['ENCFF032RDG_thyroid-gland_Normal_H3K27ac-human', 'ENCFF863WRB_thyroid-gland_Normal_H3K27ac-human']	[0.943, 0.947]	0.945	[3.458001023552876e-05, 3.2620087941485276e-07]	2.956268756445597e-10	9.770200877245268e-10
SBS4	Head-SCC	H3K36me3-human	['ENCFF385EOP_thyroid-gland_Normal_H3K36me3-human']	[1.011]	1.011	[0.15795485843249513]	0.15795485843249513	0.2278469142125879
SBS4	Head-SCC	H3K4me3-human	['ENCFF711NAW_thyroid-gland_Normal_H3K4me3-human']	[0.949]	0.949	[9.543205009357409e-08]	9.543205009357383e-08	2.797347411833788e-07
SBS4	Head-SCC	H3K9me3-human	['ENCFF071MGJ_thyroid-gland_Normal_H3K9me3-human']	[0.979]	0.979	[0.16939277798968366]	0.1693927779896836	0.24162085098379776
SBS4	Liver-HCC	H3K27ac-human	['ENCFF752QSK_liver_Normal_H3K27ac-human', 'ENCFF285MWK_right-lobe-of-liver_Normal_H3K27ac-human']	[0.874, 0.842]	0.858	[6.329465859160941e-20, 1.0266634251251884e-48]	1.0118022405535081e-65	7.582588275398068e-65
SBS4	Liver-HCC	H3K27me3-human	['ENCFF761EPK_liver_Normal_H3K27me3-human']	[0.984]	0.984	[0.038294460262504854]	0.03829446026250486	0.06536291994093912
SBS4	Liver-HCC	H3K36me3-human	['ENCFF597ACD_liver_Normal_H3K36me3-human', 'ENCFF255EYP_right-lobe-of-liver_Normal_H3K36me3-human']	[1.005, 1.018]	1.012	[0.49921081288839664, 0.06387796321608016]	0.14176088138584667	0.20760935186163879
SBS4	Liver-HCC	H3K4me1-human	['ENCFF323TFF_liver_Normal_H3K4me1-human']	[0.976]	0.976	[0.00029240564292888095]	0.0002924056429288808	0.0006799760314655246
SBS4	Liver-HCC	H3K4me3-human	['ENCFF874ZJI_liver_Normal_H3K4me3-human', 'ENCFF250OOO_right-lobe-of-liver_Normal_H3K4me3-human']	[0.899, 0.893]	0.896	[4.2534680358191304e-24, 2.795646790428197e-22]	1.2419533832791184e-43	7.600279316813362e-43
SBS4	Liver-HCC	H3K9ac-human	['ENCFF332PXX_liver_Normal_H3K9ac-human']	[0.981]	0.981	[0.21852813798281856]	0.21852813798281856	0.3001276399643871
SBS4	Liver-HCC	H3K9me3-human	['ENCFF323VPE_liver_Normal_H3K9me3-human']	[0.944]	0.944	[6.254161816866844e-05]	6.254161816866843e-05	0.00015382832622639795
SBS4	Lung-AdenoCA	H3K27ac-human	['ENCFF768OEM_lung_Normal_H3K27ac-human', 'ENCFF307QJK_upper-lobe-of-left-lung_Normal_H3K27ac-human']	[0.909, 0.871]	0.89	[2.7279226481031797e-160, 0.0]	0.0	0.0
SBS4	Lung-AdenoCA	H3K27me3-human	['ENCFF331TPT_bronchial-epithelial-cell_Normal_H3K27me3-human', 'ENCFF861IJM_lung_Normal_H3K27me3-human', 'ENCFF395QWC_upper-lobe-of-left-lung_Normal_H3K27me3-human']	[0.996, 0.989, 0.986]	0.99	[0.23681414776895204, 0.0016669305832355498, 9.286821112550013e-05]	6.0377461497124015e-06	1.6099257801561145e-05
SBS4	Lung-AdenoCA	H3K36me3-human	['ENCFF761GQJ_bronchial-epithelial-cell_Normal_H3K36me3-human', 'ENCFF592XWX_lung_Normal_H3K36me3-human', 'ENCFF344NKJ_upper-lobe-of-left-lung_Normal_H3K36me3-human']	[0.99, 0.972, 0.989]	0.984	[8.346077835582943e-07, 6.356619153890375e-56, 9.38325606262347e-14]	7.371438708670718e-71	5.7255486488197456e-70
SBS4	Lung-AdenoCA	H3K4me1-human	['ENCFF712COG_lung_Normal_H3K4me1-human', 'ENCFF433RBT_upper-lobe-of-left-lung_Normal_H3K4me1-human']	[0.95, 0.973]	0.962	[1.67383030764208e-283, 1.130514259910765e-196]	0.0	0.0
SBS4	Lung-AdenoCA	H3K4me3-human	['ENCFF772YDC_bronchial-epithelial-cell_Normal_H3K4me3-human', 'ENCFF235QPP_lung_Normal_H3K4me3-human', 'ENCFF619IKK_upper-lobe-of-left-lung_Normal_H3K4me3-human']	[0.941, 0.889, 0.876]	0.902	[4.442124169823106e-80, 1.9011052705611466e-122, 0.0]	0.0	0.0
SBS4	Lung-AdenoCA	H3K9ac-human	['ENCFF797BNU_lung_Normal_H3K9ac-human']	[0.964]	0.964	[1.6684726909844248e-15]	1.668472690984417e-15	6.4928293258693795e-15
SBS4	Lung-AdenoCA	H3K9me3-human	['ENCFF533QEX_lung_Normal_H3K9me3-human', 'ENCFF356QKI_upper-lobe-of-left-lung_Normal_H3K9me3-human']	[1.016, 0.926]	0.971	[2.650043070966772e-10, 4.400066453159382e-200]	5.6213068773407346e-207	7.09505081853829e-206
SBS4	Lung-SCC	H3K27ac-human	['ENCFF768OEM_lung_Normal_H3K27ac-human', 'ENCFF307QJK_upper-lobe-of-left-lung_Normal_H3K27ac-human']	[0.931, 0.896]	0.913	[1.6554530442358956e-43, 5.0396587092875796e-142]	3.544545836776232e-182	4.236891705828786e-181
SBS4	Lung-SCC	H3K27me3-human	['ENCFF331TPT_bronchial-epithelial-cell_Normal_H3K27me3-human', 'ENCFF861IJM_lung_Normal_H3K27me3-human', 'ENCFF395QWC_upper-lobe-of-left-lung_Normal_H3K27me3-human']	[1.015, 1.002, 0.982]	1.0	[0.0023605483067547827, 0.5786318849542325, 9.132521495110417e-06]	2.3053545495891743e-06	6.309304855045408e-06
SBS4	Lung-SCC	H3K36me3-human	['ENCFF761GQJ_bronchial-epithelial-cell_Normal_H3K36me3-human', 'ENCFF592XWX_lung_Normal_H3K36me3-human', 'ENCFF344NKJ_upper-lobe-of-left-lung_Normal_H3K36me3-human']	[1.0, 0.973, 0.992]	0.988	[0.9824443927263892, 1.1253985562694213e-25, 0.0003597505387675468]	8.768915963414012e-26	4.248274059547924e-25
SBS4	Lung-SCC	H3K4me1-human	['ENCFF712COG_lung_Normal_H3K4me1-human', 'ENCFF433RBT_upper-lobe-of-left-lung_Normal_H3K4me1-human']	[0.944, 0.977]	0.96	[7.699279827688162e-178, 1.4677151701866376e-45]	5.786362672238471e-220	7.655956404613452e-219
SBS4	Lung-SCC	H3K4me3-human	['ENCFF772YDC_bronchial-epithelial-cell_Normal_H3K4me3-human', 'ENCFF235QPP_lung_Normal_H3K4me3-human', 'ENCFF619IKK_upper-lobe-of-left-lung_Normal_H3K4me3-human']	[0.957, 0.888, 0.889]	0.911	[1.3236962434107903e-19, 5.95304450114704e-73, 2.766774091342676e-245]	0.0	0.0
SBS4	Lung-SCC	H3K9ac-human	['ENCFF797BNU_lung_Normal_H3K9ac-human']	[0.99]	0.99	[0.0668743707655829]	0.06687437076558292	0.10740768548662272
SBS4	Lung-SCC	H3K9me3-human	['ENCFF533QEX_lung_Normal_H3K9me3-human', 'ENCFF356QKI_upper-lobe-of-left-lung_Normal_H3K9me3-human']	[1.022, 0.935]	0.978	[2.4518504886383185e-11, 1.7101528157462407e-79]	8.671172509472386e-88	7.410086618896558e-87