# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 17.806 E:A[C>A]A 20.792 A:A[C>G]A 6.148 E:A[C>G]A 6.303 A:A[C>T]A 1.806 E:A[C>T]A 2.158 A:A[T>A]A 2.356 E:A[T>A]A 2.648 A:A[T>C]A 2.416 E:A[T>C]A 2.551 A:A[T>G]A 0.294 E:A[T>G]A 0.264 A:A[C>A]C 16.008 E:A[C>A]C 17.69 A:A[C>G]C 2.833 E:A[C>G]C 3.196 A:A[C>T]C 1.914 E:A[C>T]C 1.989 A:A[T>A]C 1.49 E:A[T>A]C 1.598 A:A[T>C]C 0.865 E:A[T>C]C 0.786 A:A[T>G]C 0.36 E:A[T>G]C 0.36 A:A[C>A]G 2.709 E:A[C>A]G 2.201 A:A[C>G]G 0.157 E:A[C>G]G 0.352 A:A[C>T]G 12.295 E:A[C>T]G 12.888 A:A[T>A]G 3.861 E:A[T>A]G 3.94 A:A[T>C]G 1.661 E:A[T>C]G 1.444 A:A[T>G]G 0.748 E:A[T>G]G 0.711 A:A[C>A]T 21.371 E:A[C>A]T 23.943 A:A[C>G]T 2.704 E:A[C>G]T 3.238 A:A[C>T]T 3.324 E:A[C>T]T 3.511 A:A[T>A]T 3.634 E:A[T>A]T 4.042 A:A[T>C]T 4.054 E:A[T>C]T 4.037 A:A[T>G]T 0.178 E:A[T>G]T 0.155 A:C[C>A]A 643.418 E:C[C>A]A 664.594 A:C[C>G]A 5.279 E:C[C>G]A 5.338 A:C[C>T]A 5.175 E:C[C>T]A 5.076 A:C[T>A]A 10.202 E:C[T>A]A 10.808 A:C[T>C]A 1.985 E:C[T>C]A 2.481 A:C[T>G]A 0.229 E:C[T>G]A 0.344 A:C[C>A]C 626.344 E:C[C>A]C 623.953 A:C[C>G]C 3.986 E:C[C>G]C 4.039 A:C[C>T]C 0.169 E:C[C>T]C 0.187 A:C[T>A]C 3.742 E:C[T>A]C 3.511 A:C[T>C]C 12.271 E:C[T>C]C 12.511 A:C[T>G]C 0.412 E:C[T>G]C 0.428 A:C[C>A]G 54.28 E:C[C>A]G 61.284 A:C[C>G]G 1.791 E:C[C>G]G 1.164 A:C[C>T]G 5.781 E:C[C>T]G 5.557 A:C[T>A]G 17.356 E:C[T>A]G 15.265 A:C[T>C]G 3.108 E:C[T>C]G 2.973 A:C[T>G]G 1.061 E:C[T>G]G 1.129 A:C[C>A]T 348.401 E:C[C>A]T 353.402 A:C[C>G]T 4.219 E:C[C>G]T 3.75 A:C[C>T]T 9.498 E:C[C>T]T 9.535 A:C[T>A]T 6.859 E:C[T>A]T 7.395 A:C[T>C]T 2.515 E:C[T>C]T 2.152 A:C[T>G]T 1.39 E:C[T>G]T 1.227 A:G[C>A]A 23.796 E:G[C>A]A 23.796 A:G[C>G]A 0.801 E:G[C>G]A 0.633 A:G[C>T]A 2.048 E:G[C>T]A 1.955 A:G[T>A]A 1.617 E:G[T>A]A 1.8 A:G[T>C]A 1.978 E:G[T>C]A 1.776 A:G[T>G]A 0.581 E:G[T>G]A 0.529 A:G[C>A]C 52.092 E:G[C>A]C 45.72 A:G[C>G]C 4.59 E:G[C>G]C 4.131 A:G[C>T]C 4.356 E:G[C>T]C 4.413 A:G[T>A]C 1.106 E:G[T>A]C 1.165 A:G[T>C]C 1.01 E:G[T>C]C 1.27 A:G[T>G]C 0.601 E:G[T>G]C 0.526 A:G[C>A]G 4.761 E:G[C>A]G 3.967 A:G[C>G]G 1.559 E:G[C>G]G 1.417 A:G[C>T]G 4.55 E:G[C>T]G 4.633 A:G[T>A]G 1.892 E:G[T>A]G 1.401 A:G[T>C]G 1.218 E:G[T>C]G 0.974 A:G[T>G]G 0.276 E:G[T>G]G 0.264 A:G[C>A]T 24.871 E:G[C>A]T 23.107 A:G[C>G]T 1.445 E:G[C>G]T 1.197 A:G[C>T]T 6.098 E:G[C>T]T 5.361 A:G[T>A]T 2.417 E:G[T>A]T 1.844 A:G[T>C]T 6.705 E:G[T>C]T 6.091 A:G[T>G]T 1.322 E:G[T>G]T 1.044 A:T[C>A]A 152.076 E:T[C>A]A 150.094 A:T[C>G]A 6.619 E:T[C>G]A 5.825 A:T[C>T]A 3.49 E:T[C>T]A 3.683 A:T[T>A]A 1.799 E:T[T>A]A 2.162 A:T[T>C]A 2.999 E:T[T>C]A 3.453 A:T[T>G]A 0.627 E:T[T>G]A 0.75 A:T[C>A]C 115.172 E:T[C>A]C 114.105 A:T[C>G]C 3.078 E:T[C>G]C 2.77 A:T[C>T]C 6.35 E:T[C>T]C 6.459 A:T[T>A]C 0.397 E:T[T>A]C 0.448 A:T[T>C]C 2.632 E:T[T>C]C 2.03 A:T[T>G]C 0.102 E:T[T>G]C 0.084 A:T[C>A]G 17.692 E:T[C>A]G 19.003 A:T[C>G]G 0.251 E:T[C>G]G 0.376 A:T[C>T]G 4.802 E:T[C>T]G 4.737 A:T[T>A]G 1.895 E:T[T>A]G 1.733 A:T[T>C]G 1.904 E:T[T>C]G 1.816 A:T[T>G]G 1.159 E:T[T>G]G 0.809 A:T[C>A]T 155.815 E:T[C>A]T 144.483 A:T[C>G]T 7.194 E:T[C>G]T 7.394 A:T[C>T]T 7.622 E:T[C>T]T 7.127 A:T[T>A]T 4.342 E:T[T>A]T 4.52 A:T[T>C]T 2.362 E:T[T>C]T 2.449 A:T[T>G]T 1.321 E:T[T>G]T 1.354 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list ColoRect-AdenoCA SBS45 C>A 2299.0 2332.0 2299.77 2360.36 0.7873417190269205 1.0 100.0 4631.0 Leading 1.014 1.026 0.988 2299.0 2299.77 2207.0 2374.0 [2329, 2299, 2282, 2290, 2311, 2284, 2283, 2352, 2272, 2262, 2266, 2315, 2320, 2261, 2272, 2302, 2348, 2347, 2260, 2300, 2246, 2322, 2333, 2281, 2288, 2374, 2329, 2247, 2249, 2309, 2317, 2303, 2322, 2272, 2336, 2303, 2288, 2207, 2245, 2315, 2262, 2257, 2268, 2373, 2307, 2313, 2333, 2313, 2354, 2266, 2269, 2299, 2255, 2345, 2324, 2353, 2365, 2284, 2314, 2339, 2228, 2357, 2330, 2262, 2214, 2284, 2298, 2322, 2311, 2290, 2302, 2270, 2255, 2315, 2333, 2359, 2350, 2309, 2299, 2266, 2295, 2313, 2248, 2349, 2284, 2309, 2283, 2361, 2315, 2322, 2354, 2267, 2306, 2250, 2299, 2284, 2291, 2338, 2299, 2222] 2332.0 2360.36 2282.0 2452.0 [2336, 2354, 2356, 2373, 2350, 2387, 2384, 2329, 2391, 2397, 2407, 2338, 2307, 2390, 2371, 2351, 2313, 2321, 2403, 2371, 2393, 2390, 2320, 2376, 2379, 2305, 2347, 2391, 2404, 2315, 2335, 2336, 2360, 2382, 2320, 2370, 2358, 2398, 2433, 2361, 2382, 2389, 2416, 2282, 2368, 2369, 2353, 2368, 2320, 2381, 2371, 2350, 2417, 2322, 2325, 2302, 2334, 2383, 2348, 2328, 2433, 2307, 2290, 2356, 2423, 2363, 2358, 2345, 2342, 2333, 2361, 2401, 2395, 2373, 2328, 2300, 2329, 2336, 2380, 2349, 2387, 2359, 2428, 2329, 2389, 2348, 2391, 2296, 2353, 2335, 2294, 2405, 2345, 2410, 2375, 2342, 2354, 2369, 2363, 2452] ColoRect-AdenoCA SBS45 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4631.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS45 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4631.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS45 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4631.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS45 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4631.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS45 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4631.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change