# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
signature	cancer_type	dna_element	encode_element_list	fold_change_list	avg_fold_change	p_value_list	combined_p_value	q_value
SBS45	ColoRect-AdenoCA	H3K27ac-human	['ENCFF906VKA_large-intestine_Normal_H3K27ac-human', 'ENCFF751HHK_sigmoid-colon_Normal_H3K27ac-human', 'ENCFF872JBU_transverse-colon_Normal_H3K27ac-human', 'ENCFF964IXJ_transverse-colon_Normal_H3K27ac-human', 'ENCFF110SWT_transverse-colon_Normal_H3K27ac-human', 'ENCFF338KAJ_transverse-colon_Normal_H3K27ac-human', 'ENCFF623OYB_colonic-mucosa_Normal_H3K27ac-human', 'ENCFF494RDD_mucosa-of-rectum_Normal_H3K27ac-human']	[1.047, 0.894, 0.981, 1.005, 0.978, 0.943, 1.056, 0.935]	0.98	[0.2949693151469396, 0.01323657190899344, 0.64405598017577, 0.8956688883293727, 0.5711901326378699, 0.19433351681950528, 0.3644034633549925, 0.2964324314621434]	0.1770199943042642	0.25091456156093894
SBS45	ColoRect-AdenoCA	H3K27me3-human	['ENCFF039VVN_large-intestine_Normal_H3K27me3-human', 'ENCFF838TEA_small-intestine_Normal_H3K27me3-human']	[0.95, 0.968]	0.959	[0.30547800895853117, 0.5576481370240136]	0.47185114744756596	0.568569426110705
SBS45	ColoRect-AdenoCA	H3K36me3-human	['ENCFF380EGR_large-intestine_Normal_H3K36me3-human', 'ENCFF548RZD_small-intestine_Normal_H3K36me3-human', 'ENCFF348DWR_colonic-mucosa_Normal_H3K36me3-human']	[1.022, 0.955, 0.952]	0.976	[0.3761574120162744, 0.08384357985768488, 0.1654749209035481]	0.10471832422551378	0.15876144987024138
SBS45	ColoRect-AdenoCA	H3K4me1-human	['ENCFF462DJZ_large-intestine_Normal_H3K4me1-human', 'ENCFF768QEG_small-intestine_Normal_H3K4me1-human', 'ENCFF409HTF_sigmoid-colon_Normal_H3K4me1-human', 'ENCFF940ZNY_transverse-colon_Normal_H3K4me1-human', 'ENCFF526FXD_transverse-colon_Normal_H3K4me1-human', 'ENCFF719HUM_muscle-layer-of-colon_Normal_H3K4me1-human', 'ENCFF088KTK_mucosa-of-rectum_Normal_H3K4me1-human']	[0.992, 0.944, 0.982, 0.95, 0.954, 0.988, 0.927]	0.963	[0.7758715979571689, 0.046715896276124776, 0.28059368540832674, 0.025618540557764878, 0.0019386157480640724, 0.6285904860375449, 0.030390127339432957]	0.000760494250492565	0.0016808850455875414
SBS45	ColoRect-AdenoCA	H3K4me3-human	['ENCFF752YYA_large-intestine_Normal_H3K4me3-human', 'ENCFF268EZG_small-intestine_Normal_H3K4me3-human', 'ENCFF878SLR_sigmoid-colon_Normal_H3K4me3-human', 'ENCFF287UIZ_transverse-colon_Normal_H3K4me3-human', 'ENCFF024WGB_transverse-colon_Normal_H3K4me3-human', 'ENCFF005QIU_colonic-mucosa_Normal_H3K4me3-human', 'ENCFF435EWO_muscle-layer-of-colon_Normal_H3K4me3-human', 'ENCFF114PYZ_rectal-smooth-muscle-tissue_Normal_H3K4me3-human']	[0.94, 1.071, 0.944, 0.91, 0.949, 0.908, 0.927, 0.916]	0.946	[0.2400207673912752, 0.14910600205265798, 0.1922722004294204, 0.029007816463386165, 0.23066253061677666, 0.10397231224628457, 0.12434805763506515, 0.1142737683137903]	0.007374785432399342	0.014363985636607247
SBS45	ColoRect-AdenoCA	H3K9ac-human	['ENCFF126TQW_colonic-mucosa_Normal_H3K9ac-human', 'ENCFF342OOL_mucosa-of-rectum_Normal_H3K9ac-human']	[1.055, 1.067]	1.061	[0.2822847970835113, 0.2440468669974476]	0.25318950339247775	0.34027605061889216
SBS45	ColoRect-AdenoCA	H3K9me3-human	['ENCFF536UOF_small-intestine_Normal_H3K9me3-human', 'ENCFF961RIU_transverse-colon_Normal_H3K9me3-human']	[0.955, 0.982]	0.969	[0.2084596158049007, 0.34236499933595277]	0.25977615834550316	0.3476669409039747