# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	796.042
E:A[C>A]A	858.745
A:A[C>G]A	15.538
E:A[C>G]A	18.312
A:A[C>T]A	1.644
E:A[C>T]A	1.632
A:A[T>A]A	737.374
E:A[T>A]A	771.912
A:A[T>C]A	0.339
E:A[T>C]A	0.388
A:A[T>G]A	85.295
E:A[T>G]A	87.175
A:A[C>A]C	199.921
E:A[C>A]C	189.93
A:A[C>G]C	1.555
E:A[C>G]C	1.723
A:A[C>T]C	4.195
E:A[C>T]C	4.003
A:A[T>A]C	142.329
E:A[T>A]C	143.492
A:A[T>C]C	1722.703
E:A[T>C]C	1819.544
A:A[T>G]C	45.532
E:A[T>G]C	50.889
A:A[C>A]G	24.303
E:A[C>A]G	26.226
A:A[C>G]G	78.368
E:A[C>G]G	74.054
A:A[C>T]G	48.298
E:A[C>T]G	49.913
A:A[T>A]G	101.753
E:A[T>A]G	117.269
A:A[T>C]G	15.261
E:A[T>C]G	15.974
A:A[T>G]G	422.848
E:A[T>G]G	407.267
A:A[C>A]T	84.227
E:A[C>A]T	78.242
A:A[C>G]T	11.69
E:A[C>G]T	10.214
A:A[C>T]T	86.733
E:A[C>T]T	97.836
A:A[T>A]T	238.03
E:A[T>A]T	254.451
A:A[T>C]T	93.363
E:A[T>C]T	98.223
A:A[T>G]T	84.071
E:A[T>G]T	80.503
A:C[C>A]A	263.206
E:C[C>A]A	259.925
A:C[C>G]A	0.642
E:C[C>G]A	0.635
A:C[C>T]A	0.317
E:C[C>T]A	0.321
A:C[T>A]A	113.653
E:C[T>A]A	119.159
A:C[T>C]A	124.619
E:C[T>C]A	126.78
A:C[T>G]A	34.767
E:C[T>G]A	43.613
A:C[C>A]C	4.383
E:C[C>A]C	3.876
A:C[C>G]C	3.981
E:C[C>G]C	4.8
A:C[C>T]C	0.0
E:C[C>T]C	0.0
A:C[T>A]C	0.444
E:C[T>A]C	0.577
A:C[T>C]C	4581.021
E:C[T>C]C	4694.87
A:C[T>G]C	60.136
E:C[T>G]C	63.417
A:C[C>A]G	1.131
E:C[C>A]G	0.985
A:C[C>G]G	155.753
E:C[C>G]G	161.984
A:C[C>T]G	3.844
E:C[C>T]G	3.655
A:C[T>A]G	10.349
E:C[T>A]G	10.627
A:C[T>C]G	579.195
E:C[T>C]G	571.694
A:C[T>G]G	582.012
E:C[T>G]G	581.827
A:C[C>A]T	0.0
E:C[C>A]T	0.0
A:C[C>G]T	16.089
E:C[C>G]T	16.893
A:C[C>T]T	79.95
E:C[C>T]T	80.305
A:C[T>A]T	10.124
E:C[T>A]T	9.572
A:C[T>C]T	379.802
E:C[T>C]T	386.723
A:C[T>G]T	0.0
E:C[T>G]T	0.0
A:G[C>A]A	199.605
E:G[C>A]A	182.967
A:G[C>G]A	282.142
E:G[C>G]A	288.317
A:G[C>T]A	19.471
E:G[C>T]A	22.514
A:G[T>A]A	113.352
E:G[T>A]A	120.699
A:G[T>C]A	0.0
E:G[T>C]A	0.0
A:G[T>G]A	3487.007
E:G[T>G]A	3364.463
A:G[C>A]C	24.921
E:G[C>A]C	20.67
A:G[C>G]C	235.088
E:G[C>G]C	218.467
A:G[C>T]C	0.0
E:G[C>T]C	0.0
A:G[T>A]C	20.926
E:G[T>A]C	23.662
A:G[T>C]C	1187.553
E:G[T>C]C	1119.699
A:G[T>G]C	2492.11
E:G[T>G]C	2430.235
A:G[C>A]G	7.077
E:G[C>A]G	5.802
A:G[C>G]G	620.822
E:G[C>G]G	593.369
A:G[C>T]G	0.577
E:G[C>T]G	0.511
A:G[T>A]G	77.857
E:G[T>A]G	76.075
A:G[T>C]G	46.125
E:G[T>C]G	45.855
A:G[T>G]G	9595.283
E:G[T>G]G	9103.63
A:G[C>A]T	28.162
E:G[C>A]T	24.545
A:G[C>G]T	228.155
E:G[C>G]T	196.044
A:G[C>T]T	118.259
E:G[C>T]T	113.043
A:G[T>A]T	30.05
E:G[T>A]T	25.351
A:G[T>C]T	17.56
E:G[T>C]T	16.386
A:G[T>G]T	5584.766
E:G[T>G]T	5250.868
A:T[C>A]A	370.145
E:T[C>A]A	385.431
A:T[C>G]A	0.274
E:T[C>G]A	0.279
A:T[C>T]A	4.143
E:T[C>T]A	4.324
A:T[T>A]A	21.663
E:T[T>A]A	21.433
A:T[T>C]A	3.465
E:T[T>C]A	3.46
A:T[T>G]A	7.124
E:T[T>G]A	7.313
A:T[C>A]C	0.228
E:T[C>A]C	0.266
A:T[C>G]C	26.757
E:T[C>G]C	28.386
A:T[C>T]C	0.0
E:T[C>T]C	0.0
A:T[T>A]C	20.497
E:T[T>A]C	15.155
A:T[T>C]C	2599.977
E:T[T>C]C	2555.32
A:T[T>G]C	61.551
E:T[T>G]C	67.693
A:T[C>A]G	0.0
E:T[C>A]G	0.0
A:T[C>G]G	64.712
E:T[C>G]G	67.868
A:T[C>T]G	0.0
E:T[C>T]G	0.0
A:T[T>A]G	1.484
E:T[T>A]G	1.362
A:T[T>C]G	1.116
E:T[T>C]G	1.157
A:T[T>G]G	350.472
E:T[T>G]G	368.045
A:T[C>A]T	0.0
E:T[C>A]T	0.0
A:T[C>G]T	15.004
E:T[C>G]T	12.595
A:T[C>T]T	216.304
E:T[C>T]T	192.814
A:T[T>A]T	0.0
E:T[T>A]T	0.0
A:T[T>C]T	68.986
E:T[T>C]T	71.69
A:T[T>G]T	56.64
E:T[T>G]T	51.635

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
Skin-Melanoma	SBS43	C>A	1728.0	1798.0	1739.61	1798.29	0.9052738997066828	1.0	4.41	79958.0	Leading	1.041	1.034	1.007							1728.0	1739.61	1653.0	1805.0	[1762, 1752, 1722, 1744, 1758, 1774, 1757, 1745, 1678, 1798, 1761, 1754, 1756, 1771, 1724, 1653, 1671, 1771, 1723, 1751, 1699, 1717, 1702, 1747, 1749, 1669, 1746, 1761, 1691, 1718, 1690, 1710, 1727, 1740, 1750, 1777, 1720, 1736, 1734, 1734, 1800, 1751, 1701, 1749, 1735, 1802, 1805, 1738, 1697, 1747, 1756, 1721, 1711, 1703, 1774, 1786, 1720, 1747, 1746, 1769, 1778, 1759, 1757, 1750, 1761, 1722, 1782, 1721, 1725, 1780, 1712, 1753, 1774, 1777, 1731, 1698, 1762, 1708, 1737, 1757, 1752, 1715, 1708, 1727, 1717, 1741, 1747, 1736, 1751, 1710, 1731, 1699, 1750, 1755, 1768, 1763, 1721, 1794, 1699, 1733]	1798.0	1798.29	1722.0	1875.0	[1785, 1801, 1802, 1783, 1790, 1764, 1782, 1814, 1863, 1740, 1791, 1752, 1771, 1754, 1821, 1854, 1875, 1787, 1857, 1785, 1845, 1848, 1830, 1805, 1765, 1798, 1806, 1784, 1812, 1802, 1823, 1822, 1809, 1825, 1776, 1773, 1809, 1810, 1774, 1787, 1722, 1812, 1836, 1803, 1802, 1745, 1731, 1798, 1846, 1812, 1756, 1800, 1796, 1844, 1761, 1773, 1825, 1824, 1786, 1762, 1735, 1778, 1786, 1795, 1811, 1784, 1770, 1806, 1794, 1739, 1826, 1774, 1808, 1766, 1827, 1835, 1796, 1786, 1799, 1776, 1800, 1857, 1796, 1796, 1827, 1814, 1772, 1845, 1789, 1819, 1829, 1852, 1775, 1771, 1774, 1797, 1812, 1775, 1833, 1797]
Skin-Melanoma	SBS43	C>G	1800.0	1745.0	1765.4	1767.26	0.5056440462660194	0.934928561330544	4.434	79958.0	Lagging	1.032	0.999	1.033							1800.0	1765.4	1686.0	1846.0	[1788, 1807, 1778, 1786, 1770, 1756, 1713, 1777, 1846, 1740, 1817, 1785, 1768, 1794, 1771, 1769, 1735, 1792, 1761, 1824, 1736, 1746, 1736, 1787, 1744, 1753, 1784, 1738, 1737, 1779, 1737, 1753, 1791, 1725, 1796, 1752, 1765, 1759, 1737, 1756, 1783, 1778, 1754, 1728, 1790, 1779, 1791, 1719, 1760, 1796, 1733, 1718, 1734, 1788, 1788, 1797, 1753, 1745, 1800, 1779, 1787, 1770, 1709, 1740, 1804, 1804, 1759, 1771, 1771, 1741, 1713, 1778, 1787, 1812, 1763, 1718, 1770, 1795, 1816, 1805, 1753, 1770, 1764, 1723, 1737, 1749, 1805, 1762, 1759, 1767, 1765, 1780, 1817, 1740, 1743, 1775, 1745, 1686, 1729, 1757]	1745.0	1767.26	1705.0	1837.0	[1725, 1727, 1753, 1745, 1760, 1756, 1798, 1764, 1724, 1786, 1746, 1722, 1732, 1736, 1766, 1753, 1829, 1760, 1764, 1741, 1800, 1795, 1781, 1748, 1797, 1815, 1747, 1788, 1780, 1751, 1788, 1788, 1737, 1796, 1736, 1768, 1748, 1776, 1785, 1761, 1765, 1750, 1803, 1800, 1762, 1774, 1774, 1804, 1746, 1745, 1789, 1790, 1797, 1748, 1721, 1724, 1786, 1778, 1705, 1772, 1761, 1783, 1807, 1756, 1748, 1738, 1786, 1783, 1749, 1837, 1815, 1751, 1740, 1754, 1761, 1807, 1790, 1741, 1725, 1711, 1737, 1758, 1752, 1815, 1766, 1783, 1728, 1774, 1756, 1782, 1791, 1753, 1761, 1794, 1815, 1756, 1809, 1794, 1781, 1773]
Skin-Melanoma	SBS43	C>T	139.0	130.0	135.41	134.7	0.7958782424006687	1.0	0.336	79958.0	Lagging	1.069	1.005	1.064							139.0	135.41	110.0	153.0	[137, 124, 136, 150, 130, 129, 133, 130, 131, 144, 127, 143, 133, 128, 136, 136, 137, 135, 144, 119, 130, 137, 142, 138, 129, 141, 142, 127, 126, 131, 141, 137, 141, 146, 143, 131, 141, 153, 125, 134, 149, 138, 140, 116, 138, 139, 152, 133, 138, 132, 147, 132, 144, 144, 135, 152, 128, 145, 135, 128, 128, 136, 136, 131, 123, 139, 129, 110, 130, 139, 147, 142, 123, 138, 134, 139, 134, 152, 132, 132, 136, 132, 123, 132, 135, 113, 145, 144, 116, 144, 135, 147, 142, 140, 129, 133, 136, 126, 126, 151]	130.0	134.7	117.0	157.0	[135, 141, 134, 125, 142, 145, 137, 139, 130, 122, 144, 121, 136, 150, 132, 132, 131, 141, 129, 153, 133, 134, 127, 131, 141, 130, 122, 135, 143, 133, 123, 133, 131, 126, 137, 145, 130, 123, 145, 143, 124, 134, 132, 149, 135, 140, 117, 138, 125, 127, 119, 139, 125, 117, 137, 124, 146, 122, 136, 136, 140, 137, 131, 134, 147, 133, 145, 157, 143, 137, 122, 130, 142, 133, 140, 130, 144, 118, 140, 139, 131, 137, 144, 142, 137, 156, 131, 123, 143, 134, 142, 124, 127, 138, 141, 136, 123, 144, 146, 123]
Skin-Melanoma	SBS43	T>A	1197.0	1417.0	1306.54	1311.22	0.0030591073956772645	0.011941614051312182	3.269	79958.0	Leading	1.184	1.004	1.18	1						1197.0	1306.54	1247.0	1388.0	[1333, 1300, 1298, 1277, 1270, 1304, 1255, 1365, 1325, 1300, 1314, 1323, 1295, 1325, 1312, 1335, 1298, 1299, 1278, 1293, 1340, 1312, 1247, 1309, 1253, 1297, 1341, 1328, 1345, 1275, 1288, 1313, 1321, 1274, 1304, 1338, 1282, 1286, 1299, 1310, 1297, 1326, 1312, 1289, 1338, 1319, 1295, 1346, 1291, 1293, 1275, 1309, 1276, 1296, 1298, 1361, 1356, 1324, 1325, 1305, 1333, 1317, 1299, 1341, 1289, 1298, 1361, 1288, 1353, 1388, 1298, 1284, 1295, 1301, 1327, 1314, 1282, 1312, 1260, 1266, 1289, 1265, 1306, 1325, 1311, 1313, 1334, 1367, 1293, 1281, 1337, 1296, 1299, 1310, 1280, 1296, 1287, 1286, 1291, 1290]	1417.0	1311.22	1217.0	1381.0	[1291, 1323, 1316, 1300, 1372, 1317, 1350, 1261, 1298, 1336, 1290, 1293, 1310, 1319, 1290, 1272, 1298, 1340, 1328, 1315, 1295, 1289, 1353, 1322, 1332, 1312, 1307, 1316, 1266, 1349, 1314, 1290, 1283, 1338, 1320, 1297, 1317, 1324, 1347, 1328, 1286, 1295, 1303, 1330, 1274, 1289, 1342, 1265, 1324, 1326, 1340, 1316, 1381, 1314, 1335, 1282, 1290, 1319, 1289, 1330, 1285, 1309, 1363, 1298, 1330, 1312, 1254, 1342, 1269, 1217, 1342, 1319, 1335, 1307, 1304, 1295, 1321, 1264, 1358, 1338, 1317, 1344, 1306, 1299, 1322, 1304, 1314, 1261, 1302, 1287, 1261, 1320, 1313, 1303, 1331, 1323, 1329, 1316, 1327, 1333]
Skin-Melanoma	SBS43	T>C	11670.0	12233.0	11922.76	11879.76	0.005682218884339486	0.021419198002641943	29.894	79958.0	Leading	1.048	0.996	1.052							11670.0	11922.76	11708.0	12122.0	[12038, 11829, 11969, 11818, 11952, 11970, 11934, 12122, 11793, 11815, 11940, 11838, 11949, 11996, 11913, 11836, 11848, 11908, 11843, 11917, 11946, 12028, 11802, 11911, 12058, 11987, 12055, 11967, 11963, 11869, 11792, 11812, 11918, 11861, 12002, 11917, 11980, 11708, 11979, 11955, 12110, 11825, 11891, 11807, 12068, 12019, 12031, 12006, 11931, 12001, 11866, 11953, 11788, 11945, 11980, 11753, 11867, 12000, 11889, 11942, 12019, 11980, 11899, 11912, 11823, 11961, 11899, 11805, 12020, 11993, 12036, 11974, 11863, 11956, 11988, 11869, 11989, 12022, 11877, 11992, 11846, 11783, 11881, 11820, 11965, 11957, 11866, 11849, 12065, 11936, 11790, 11876, 11940, 11891, 11847, 11907, 11896, 11898, 11935, 12041]	12233.0	11879.76	11654.0	12066.0	[11797, 11990, 11870, 11933, 11882, 11866, 11797, 11739, 11957, 11944, 11861, 11867, 11911, 11869, 11881, 11985, 12013, 11910, 11933, 11888, 11812, 11829, 12008, 11905, 11756, 11868, 11826, 11891, 11803, 11896, 11933, 11976, 11912, 11992, 11820, 11911, 11842, 12042, 11968, 11847, 11654, 11875, 11897, 11922, 11730, 11862, 11813, 11888, 11821, 11773, 11907, 11859, 11994, 11771, 11833, 11945, 11854, 11910, 11876, 11812, 11778, 11900, 11871, 11854, 11951, 11823, 11924, 11961, 11774, 11822, 11704, 11803, 11888, 11800, 11761, 11903, 11921, 11769, 11960, 11896, 11984, 12066, 11931, 11938, 11829, 11802, 12001, 11976, 11876, 11804, 11923, 11886, 11874, 11885, 11926, 11870, 11950, 11917, 11948, 11801]
Skin-Melanoma	SBS43	T>G	23714.0	22387.0	23285.29	22546.85	0.05569603154524913	0.1725386108807183	57.657	79958.0	Lagging	1.059	1.033	1.026							23714.0	23285.29	23082.0	23520.0	[23158, 23253, 23364, 23468, 23404, 23520, 23158, 23180, 23129, 23286, 23212, 23159, 23389, 23137, 23373, 23208, 23252, 23402, 23154, 23278, 23301, 23427, 23185, 23185, 23300, 23336, 23303, 23401, 23330, 23453, 23151, 23150, 23194, 23210, 23242, 23298, 23369, 23472, 23361, 23344, 23278, 23230, 23120, 23214, 23082, 23185, 23372, 23386, 23259, 23160, 23118, 23261, 23427, 23240, 23320, 23189, 23203, 23436, 23209, 23324, 23380, 23143, 23517, 23264, 23377, 23402, 23379, 23209, 23218, 23265, 23383, 23410, 23263, 23311, 23214, 23370, 23245, 23165, 23136, 23317, 23186, 23218, 23227, 23206, 23283, 23307, 23396, 23113, 23367, 23471, 23211, 23296, 23316, 23187, 23505, 23308, 23363, 23354, 23436, 23302]	22387.0	22546.85	22269.0	22750.0	[22706, 22587, 22337, 22293, 22411, 22269, 22750, 22562, 22663, 22549, 22705, 22622, 22410, 22735, 22378, 22608, 22666, 22482, 22543, 22611, 22475, 22384, 22697, 22672, 22622, 22547, 22543, 22432, 22478, 22470, 22684, 22730, 22626, 22645, 22479, 22730, 22371, 22590, 22466, 22488, 22553, 22593, 22648, 22596, 22697, 22464, 22512, 22440, 22547, 22576, 22638, 22595, 22457, 22536, 22486, 22594, 22499, 22407, 22564, 22460, 22351, 22702, 22349, 22502, 22501, 22515, 22535, 22730, 22545, 22560, 22489, 22443, 22474, 22536, 22611, 22424, 22723, 22585, 22687, 22557, 22641, 22641, 22576, 22563, 22535, 22563, 22478, 22675, 22581, 22452, 22704, 22564, 22568, 22660, 22426, 22431, 22563, 22472, 22420, 22475]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS43	T>C	Leading	[]	0	[]	0	[]	0	[]	0	[]	0	[]	0	['Skin-Melanoma']	1