# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 24.013 E:A[C>A]A 24.515 A:A[C>G]A 50.035 E:A[C>G]A 51.674 A:A[C>T]A 83.785 E:A[C>T]A 86.727 A:A[T>A]A 134.479 E:A[T>A]A 142.056 A:A[T>C]A 154.879 E:A[T>C]A 154.781 A:A[T>G]A 145.508 E:A[T>G]A 151.88 A:A[C>A]C 15.244 E:A[C>A]C 16.753 A:A[C>G]C 26.357 E:A[C>G]C 27.286 A:A[C>T]C 27.92 E:A[C>T]C 28.098 A:A[T>A]C 53.125 E:A[T>A]C 57.596 A:A[T>C]C 56.583 E:A[T>C]C 51.43 A:A[T>G]C 19.725 E:A[T>G]C 19.643 A:A[C>A]G 0.835 E:A[C>A]G 0.78 A:A[C>G]G 19.149 E:A[C>G]G 19.964 A:A[C>T]G 35.169 E:A[C>T]G 34.831 A:A[T>A]G 32.373 E:A[T>A]G 33.046 A:A[T>C]G 62.253 E:A[T>C]G 60.517 A:A[T>G]G 23.072 E:A[T>G]G 23.299 A:A[C>A]T 22.046 E:A[C>A]T 21.351 A:A[C>G]T 91.05 E:A[C>G]T 87.583 A:A[C>T]T 53.565 E:A[C>T]T 53.946 A:A[T>A]T 683.256 E:A[T>A]T 713.126 A:A[T>C]T 126.15 E:A[T>C]T 123.113 A:A[T>G]T 106.185 E:A[T>G]T 99.505 A:C[C>A]A 25.597 E:C[C>A]A 25.075 A:C[C>G]A 18.371 E:C[C>G]A 18.641 A:C[C>T]A 71.08 E:C[C>T]A 71.668 A:C[T>A]A 77.447 E:C[T>A]A 85.445 A:C[T>C]A 155.025 E:C[T>C]A 160.811 A:C[T>G]A 67.183 E:C[T>G]A 70.213 A:C[C>A]C 11.193 E:C[C>A]C 11.114 A:C[C>G]C 6.644 E:C[C>G]C 7.72 A:C[C>T]C 17.73 E:C[C>T]C 17.8 A:C[T>A]C 39.999 E:C[T>A]C 40.124 A:C[T>C]C 55.788 E:C[T>C]C 53.491 A:C[T>G]C 33.83 E:C[T>G]C 30.99 A:C[C>A]G 2.476 E:C[C>A]G 2.461 A:C[C>G]G 3.585 E:C[C>G]G 3.535 A:C[C>T]G 90.582 E:C[C>T]G 88.907 A:C[T>A]G 46.809 E:C[T>A]G 45.727 A:C[T>C]G 52.378 E:C[T>C]G 47.222 A:C[T>G]G 41.348 E:C[T>G]G 37.522 A:C[C>A]T 47.634 E:C[C>A]T 42.519 A:C[C>G]T 37.718 E:C[C>G]T 36.516 A:C[C>T]T 75.757 E:C[C>T]T 77.052 A:C[T>A]T 165.084 E:C[T>A]T 151.015 A:C[T>C]T 91.634 E:C[T>C]T 85.584 A:C[T>G]T 144.248 E:C[T>G]T 133.433 A:G[C>A]A 26.772 E:G[C>A]A 27.937 A:G[C>G]A 17.538 E:G[C>G]A 20.415 A:G[C>T]A 57.899 E:G[C>T]A 56.069 A:G[T>A]A 39.66 E:G[T>A]A 37.746 A:G[T>C]A 90.086 E:G[T>C]A 87.474 A:G[T>G]A 23.128 E:G[T>G]A 23.857 A:G[C>A]C 7.735 E:G[C>A]C 8.369 A:G[C>G]C 26.698 E:G[C>G]C 25.847 A:G[C>T]C 87.962 E:G[C>T]C 88.343 A:G[T>A]C 32.862 E:G[T>A]C 32.266 A:G[T>C]C 52.063 E:G[T>C]C 48.081 A:G[T>G]C 13.11 E:G[T>G]C 13.225 A:G[C>A]G 1.648 E:G[C>A]G 1.554 A:G[C>G]G 1.74 E:G[C>G]G 1.546 A:G[C>T]G 203.125 E:G[C>T]G 212.112 A:G[T>A]G 23.261 E:G[T>A]G 21.55 A:G[T>C]G 36.048 E:G[T>C]G 34.99 A:G[T>G]G 12.669 E:G[T>G]G 12.811 A:G[C>A]T 24.431 E:G[C>A]T 22.2 A:G[C>G]T 33.3 E:G[C>G]T 31.834 A:G[C>T]T 85.677 E:G[C>T]T 83.236 A:G[T>A]T 77.493 E:G[T>A]T 71.47 A:G[T>C]T 60.238 E:G[T>C]T 54.309 A:G[T>G]T 60.821 E:G[T>G]T 55.732 A:T[C>A]A 47.641 E:T[C>A]A 44.893 A:T[C>G]A 260.606 E:T[C>G]A 230.574 A:T[C>T]A 169.442 E:T[C>T]A 161.209 A:T[T>A]A 573.305 E:T[T>A]A 588.608 A:T[T>C]A 791.88 E:T[T>C]A 795.56 A:T[T>G]A 464.105 E:T[T>G]A 428.495 A:T[C>A]C 16.559 E:T[C>A]C 16.81 A:T[C>G]C 108.614 E:T[C>G]C 105.855 A:T[C>T]C 75.392 E:T[C>T]C 70.383 A:T[T>A]C 120.881 E:T[T>A]C 128.797 A:T[T>C]C 310.37 E:T[T>C]C 293.281 A:T[T>G]C 112.67 E:T[T>G]C 111.818 A:T[C>A]G 1.705 E:T[C>A]G 1.691 A:T[C>G]G 20.159 E:T[C>G]G 18.095 A:T[C>T]G 55.537 E:T[C>T]G 51.189 A:T[T>A]G 99.488 E:T[T>A]G 95.328 A:T[T>C]G 207.462 E:T[T>C]G 192.281 A:T[T>G]G 157.601 E:T[T>G]G 156.799 A:T[C>A]T 86.782 E:T[C>A]T 80.527 A:T[C>G]T 531.598 E:T[C>G]T 478.063 A:T[C>T]T 174.575 E:T[C>T]T 155.821 A:T[T>A]T 531.156 E:T[T>A]T 502.11 A:T[T>C]T 452.349 E:T[T>C]T 432.132 A:T[T>G]T 885.825 E:T[T>G]T 844.819 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Ovary-AdenoCA SBS41 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3521.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS41 C>G 349.0 268.0 316.08 308.27 0.04042390466368208 0.1294504240873537 17.523 3521.0 Lagging 1.302 1.025 1.27 1 1 349.0 316.08 289.0 347.0 [313, 338, 310, 298, 328, 309, 332, 322, 317, 312, 309, 319, 315, 347, 331, 308, 321, 322, 320, 326, 312, 326, 326, 303, 301, 322, 325, 311, 334, 311, 303, 292, 327, 303, 320, 333, 337, 315, 313, 326, 306, 329, 326, 321, 324, 321, 306, 298, 314, 311, 319, 306, 309, 304, 320, 315, 333, 323, 306, 299, 307, 311, 320, 317, 313, 308, 327, 315, 322, 318, 306, 324, 324, 292, 320, 289, 306, 319, 310, 311, 310, 319, 310, 333, 340, 303, 322, 310, 322, 313, 317, 324, 307, 295, 323, 314, 322, 313, 314, 311] 268.0 308.27 281.0 333.0 [313, 295, 305, 327, 304, 305, 299, 301, 314, 301, 310, 317, 297, 286, 298, 312, 300, 297, 313, 317, 309, 306, 311, 320, 318, 292, 301, 315, 297, 317, 317, 333, 302, 319, 306, 298, 281, 309, 304, 288, 316, 303, 299, 301, 284, 304, 319, 321, 303, 312, 303, 314, 319, 322, 301, 306, 306, 317, 320, 321, 320, 314, 306, 309, 322, 326, 301, 303, 304, 320, 315, 311, 302, 332, 306, 329, 317, 305, 308, 308, 313, 301, 313, 283, 291, 315, 300, 311, 307, 297, 300, 308, 310, 332, 304, 310, 297, 316, 307, 309] Ovary-AdenoCA SBS41 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3521.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS41 T>A 1137.0 1144.0 1146.51 1111.55 0.5331201512684944 0.9650473857897255 64.783 3521.0 Leading 1.006 0.97 1.038 1137.0 1146.51 1090.0 1224.0 [1147, 1096, 1101, 1167, 1110, 1118, 1144, 1095, 1124, 1183, 1221, 1162, 1162, 1138, 1133, 1169, 1145, 1134, 1180, 1090, 1151, 1143, 1152, 1154, 1175, 1132, 1136, 1137, 1149, 1169, 1104, 1171, 1130, 1130, 1123, 1151, 1149, 1158, 1113, 1224, 1138, 1167, 1149, 1114, 1147, 1145, 1148, 1154, 1127, 1150, 1195, 1179, 1109, 1150, 1146, 1175, 1135, 1141, 1155, 1119, 1145, 1184, 1153, 1159, 1149, 1136, 1100, 1183, 1115, 1161, 1119, 1111, 1139, 1157, 1153, 1167, 1116, 1125, 1155, 1164, 1184, 1170, 1150, 1157, 1169, 1192, 1164, 1141, 1131, 1114, 1094, 1164, 1168, 1144, 1166, 1154, 1134, 1126, 1157, 1168] 1144.0 1111.55 1055.0 1179.0 [1116, 1139, 1167, 1100, 1165, 1132, 1103, 1155, 1153, 1107, 1074, 1079, 1126, 1097, 1117, 1101, 1114, 1124, 1067, 1179, 1116, 1112, 1103, 1116, 1090, 1122, 1124, 1096, 1121, 1093, 1126, 1100, 1142, 1118, 1128, 1106, 1107, 1083, 1121, 1055, 1128, 1108, 1118, 1133, 1110, 1106, 1111, 1113, 1133, 1095, 1076, 1076, 1145, 1104, 1096, 1080, 1107, 1089, 1117, 1157, 1106, 1082, 1109, 1130, 1119, 1111, 1157, 1095, 1127, 1099, 1115, 1135, 1119, 1099, 1091, 1096, 1120, 1147, 1076, 1094, 1087, 1071, 1113, 1091, 1097, 1099, 1087, 1114, 1149, 1128, 1133, 1106, 1101, 1100, 1085, 1108, 1095, 1145, 1098, 1125] Ovary-AdenoCA SBS41 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3521.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS41 T>G 328.0 295.0 320.56 302.14 0.6914323992891421 1.0 17.694 3521.0 Lagging 1.112 1.061 1.048 328.0 320.56 294.0 363.0 [307, 320, 324, 316, 313, 317, 349, 324, 320, 319, 319, 328, 335, 330, 310, 319, 314, 363, 313, 312, 331, 318, 324, 316, 309, 298, 324, 325, 316, 309, 321, 299, 316, 312, 309, 344, 318, 320, 311, 334, 332, 315, 328, 357, 324, 333, 313, 341, 303, 326, 327, 313, 326, 310, 320, 331, 325, 334, 315, 307, 338, 314, 294, 311, 331, 336, 309, 319, 330, 307, 328, 325, 321, 318, 319, 317, 321, 341, 313, 320, 327, 318, 314, 307, 318, 320, 338, 309, 324, 314, 322, 326, 305, 320, 315, 312, 341, 297, 298, 333] 295.0 302.14 273.0 327.0 [325, 305, 303, 315, 308, 313, 280, 299, 308, 303, 306, 300, 295, 292, 316, 294, 300, 274, 306, 317, 293, 299, 296, 309, 309, 313, 302, 299, 319, 312, 303, 327, 301, 314, 310, 273, 306, 299, 295, 289, 294, 303, 300, 277, 302, 288, 309, 288, 309, 292, 292, 299, 288, 308, 305, 301, 296, 291, 314, 313, 281, 304, 314, 306, 306, 283, 312, 315, 297, 317, 289, 296, 310, 298, 301, 309, 311, 285, 307, 307, 288, 299, 309, 314, 302, 308, 291, 319, 301, 301, 299, 303, 326, 291, 300, 302, 275, 326, 326, 290] Stomach-AdenoCA SBS41 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10149.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS41 C>G 207.0 171.0 193.57 191.3 0.2183271284253933 0.5272040338323439 3.725 10149.0 Lagging 1.211 1.012 1.196 1 1 207.0 193.57 170.0 220.0 [191, 195, 192, 195, 190, 173, 193, 193, 201, 187, 173, 193, 197, 199, 210, 189, 210, 181, 208, 192, 206, 197, 202, 191, 183, 178, 194, 194, 189, 192, 186, 206, 190, 182, 189, 214, 204, 202, 190, 183, 189, 190, 202, 170, 203, 176, 202, 199, 186, 198, 192, 195, 205, 196, 210, 184, 195, 206, 185, 198, 193, 191, 205, 196, 180, 199, 199, 216, 204, 200, 188, 197, 195, 209, 189, 190, 187, 179, 220, 194, 204, 184, 206, 185, 179, 201, 206, 207, 181, 175, 188, 199, 186, 185, 189, 173, 188, 188, 191, 196] 171.0 191.3 166.0 215.0 [192, 195, 191, 185, 191, 205, 194, 193, 185, 210, 206, 191, 185, 191, 190, 188, 186, 197, 166, 198, 185, 190, 180, 193, 193, 201, 191, 196, 200, 192, 199, 185, 193, 203, 194, 179, 181, 185, 202, 201, 195, 200, 174, 212, 185, 207, 188, 182, 194, 184, 193, 190, 181, 191, 180, 198, 182, 175, 198, 176, 184, 191, 169, 195, 197, 183, 188, 182, 179, 188, 204, 189, 183, 177, 203, 188, 195, 215, 175, 197, 175, 198, 188, 201, 195, 183, 177, 171, 212, 214, 200, 199, 201, 204, 190, 207, 195, 194, 191, 186] Stomach-AdenoCA SBS41 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10149.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS41 T>A 2552.0 2729.0 2700.34 2615.42 0.010924051525664691 0.039341206593861276 52.035 10149.0 Leading 1.069 0.969 1.104 1 2552.0 2700.34 2613.0 2806.0 [2667, 2656, 2692, 2701, 2729, 2660, 2713, 2674, 2806, 2695, 2710, 2673, 2702, 2722, 2716, 2678, 2637, 2726, 2723, 2707, 2678, 2708, 2721, 2681, 2614, 2679, 2694, 2768, 2716, 2692, 2718, 2683, 2750, 2643, 2692, 2739, 2674, 2621, 2698, 2676, 2678, 2680, 2716, 2670, 2757, 2707, 2742, 2699, 2729, 2679, 2716, 2759, 2704, 2694, 2708, 2695, 2709, 2771, 2707, 2722, 2750, 2736, 2732, 2707, 2721, 2677, 2718, 2681, 2693, 2613, 2715, 2665, 2726, 2729, 2668, 2739, 2701, 2739, 2688, 2683, 2721, 2638, 2689, 2712, 2657, 2730, 2740, 2741, 2690, 2763, 2697, 2645, 2705, 2700, 2624, 2652, 2674, 2670, 2700, 2731] 2729.0 2615.42 2528.0 2702.0 [2626, 2639, 2637, 2674, 2590, 2649, 2628, 2644, 2545, 2603, 2614, 2607, 2607, 2599, 2567, 2628, 2660, 2596, 2563, 2594, 2658, 2606, 2621, 2621, 2672, 2702, 2629, 2590, 2600, 2601, 2573, 2639, 2572, 2694, 2594, 2605, 2616, 2673, 2594, 2672, 2635, 2623, 2601, 2625, 2591, 2608, 2604, 2626, 2563, 2651, 2537, 2561, 2652, 2578, 2581, 2647, 2613, 2547, 2578, 2555, 2582, 2600, 2605, 2595, 2627, 2633, 2630, 2626, 2642, 2697, 2616, 2621, 2591, 2593, 2647, 2604, 2578, 2596, 2593, 2690, 2605, 2652, 2625, 2625, 2669, 2599, 2549, 2570, 2630, 2528, 2637, 2686, 2598, 2642, 2688, 2631, 2600, 2627, 2648, 2589] Stomach-AdenoCA SBS41 T>C 1113.0 1234.0 1198.94 1173.11 0.033532609943548335 0.109936763844514 23.125 10149.0 Leading 1.109 0.978 1.133 1 1113.0 1198.94 1145.0 1261.0 [1208, 1206, 1219, 1180, 1213, 1149, 1186, 1211, 1187, 1201, 1215, 1200, 1200, 1199, 1210, 1206, 1159, 1221, 1186, 1243, 1170, 1165, 1261, 1214, 1215, 1179, 1219, 1252, 1194, 1201, 1206, 1154, 1169, 1207, 1219, 1212, 1202, 1203, 1175, 1193, 1213, 1208, 1210, 1162, 1207, 1256, 1189, 1210, 1210, 1193, 1196, 1204, 1212, 1224, 1203, 1199, 1145, 1188, 1187, 1194, 1211, 1175, 1192, 1210, 1223, 1199, 1209, 1180, 1194, 1185, 1199, 1173, 1198, 1197, 1190, 1227, 1205, 1177, 1176, 1250, 1174, 1207, 1183, 1179, 1153, 1200, 1258, 1164, 1221, 1181, 1224, 1200, 1187, 1208, 1187, 1219, 1200, 1191, 1191, 1178] 1234.0 1173.11 1098.0 1222.0 [1176, 1167, 1143, 1173, 1160, 1191, 1193, 1149, 1199, 1169, 1171, 1173, 1173, 1158, 1157, 1167, 1211, 1156, 1188, 1139, 1197, 1210, 1134, 1167, 1165, 1203, 1183, 1113, 1194, 1184, 1198, 1222, 1185, 1155, 1144, 1172, 1149, 1176, 1197, 1189, 1136, 1182, 1164, 1186, 1171, 1098, 1186, 1151, 1160, 1185, 1171, 1169, 1153, 1155, 1167, 1172, 1220, 1205, 1194, 1161, 1183, 1200, 1183, 1168, 1160, 1158, 1135, 1185, 1182, 1182, 1152, 1209, 1191, 1162, 1185, 1129, 1145, 1190, 1182, 1127, 1214, 1176, 1183, 1201, 1194, 1181, 1123, 1208, 1163, 1157, 1165, 1176, 1185, 1171, 1179, 1169, 1199, 1186, 1172, 1165] Stomach-AdenoCA SBS41 T>G 1046.0 1097.0 1083.25 1058.31 0.2582142977838251 0.5978446587287456 21.115 10149.0 Leading 1.049 0.977 1.073 1046.0 1083.25 1027.0 1159.0 [1136, 1067, 1127, 1079, 1106, 1033, 1069, 1079, 1091, 1072, 1109, 1118, 1058, 1082, 1029, 1027, 1091, 1115, 1080, 1057, 1102, 1064, 1053, 1046, 1097, 1048, 1091, 1101, 1081, 1085, 1089, 1083, 1097, 1092, 1039, 1069, 1159, 1093, 1101, 1083, 1063, 1090, 1100, 1079, 1064, 1058, 1092, 1106, 1055, 1108, 1085, 1121, 1128, 1060, 1088, 1056, 1087, 1064, 1115, 1075, 1074, 1127, 1072, 1111, 1120, 1054, 1032, 1111, 1100, 1064, 1082, 1051, 1095, 1085, 1079, 1129, 1046, 1081, 1069, 1084, 1092, 1149, 1106, 1080, 1087, 1073, 1068, 1059, 1060, 1092, 1059, 1104, 1119, 1064, 1078, 1090, 1084, 1067, 1077, 1059] 1097.0 1058.31 983.0 1116.0 [983, 1069, 1011, 1069, 1054, 1116, 1065, 1065, 1064, 1048, 1026, 1045, 1073, 1068, 1078, 1108, 1039, 1025, 1052, 1084, 1073, 1078, 1044, 1084, 1030, 1096, 1047, 1030, 1038, 1076, 1058, 1068, 1033, 1042, 1089, 1090, 1003, 1051, 1035, 1057, 1079, 1048, 1035, 1068, 1077, 1077, 1063, 1048, 1115, 1026, 1060, 1018, 1019, 1070, 1062, 1087, 1094, 1077, 1036, 1085, 1055, 1026, 1062, 1059, 1017, 1094, 1094, 1029, 1025, 1052, 1063, 1070, 1043, 1075, 1068, 997, 1094, 1049, 1091, 1047, 1060, 1004, 1052, 1045, 1054, 1083, 1059, 1086, 1087, 1043, 1062, 1050, 1030, 1091, 1066, 1046, 1042, 1069, 1075, 1109] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS41 T>A Leading ['Stomach-AdenoCA'] 1 [] 0 [] 0 [] 0 [] 0 [] 0 ['Ovary-AdenoCA', 'Stomach-AdenoCA'] 2 1.1