# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types. MutationType Across_All_Cancer_Types T:A[C>A]A 6.5 U:A[C>A]A 4.5 B:A[C>A]A 0.0 N:A[C>A]A 35.5 T:A[C>A]C 4.0 U:A[C>A]C 2.5 B:A[C>A]C 0.0 N:A[C>A]C 20.5 T:A[C>A]G 0.0 U:A[C>A]G 0.0 B:A[C>A]G 0.0 N:A[C>A]G 0.0 T:A[C>A]T 4.0 U:A[C>A]T 5.0 B:A[C>A]T 0.0 N:A[C>A]T 28.0 T:A[C>G]A 19.5 U:A[C>G]A 15.0 B:A[C>G]A 0.0 N:A[C>G]A 68.0 T:A[C>G]C 9.5 U:A[C>G]C 6.5 B:A[C>G]C 0.0 N:A[C>G]C 34.5 T:A[C>G]G 7.0 U:A[C>G]G 7.0 B:A[C>G]G 0.0 N:A[C>G]G 18.0 T:A[C>G]T 32.5 U:A[C>G]T 33.0 B:A[C>G]T 0.0 N:A[C>G]T 112.5 T:A[C>T]A 33.5 U:A[C>T]A 27.0 B:A[C>T]A 0.0 N:A[C>T]A 111.0 T:A[C>T]C 9.0 U:A[C>T]C 8.5 B:A[C>T]C 0.0 N:A[C>T]C 34.0 T:A[C>T]G 12.5 U:A[C>T]G 9.5 B:A[C>T]G 0.0 N:A[C>T]G 45.5 T:A[C>T]T 19.0 U:A[C>T]T 16.5 B:A[C>T]T 0.0 N:A[C>T]T 76.5 T:A[T>A]A 56.5 U:A[T>A]A 46.5 B:A[T>A]A 0.5 N:A[T>A]A 190.5 T:A[T>A]C 19.5 U:A[T>A]C 14.5 B:A[T>A]C 0.0 N:A[T>A]C 81.0 T:A[T>A]G 10.5 U:A[T>A]G 9.0 B:A[T>A]G 0.0 N:A[T>A]G 46.0 T:A[T>A]T 291.5 U:A[T>A]T 277.0 B:A[T>A]T 4.0 N:A[T>A]T 1001.0 T:A[T>C]A 55.5 U:A[T>C]A 52.0 B:A[T>C]A 0.0 N:A[T>C]A 227.0 T:A[T>C]C 18.0 U:A[T>C]C 17.5 B:A[T>C]C 0.0 N:A[T>C]C 78.5 T:A[T>C]G 21.0 U:A[T>C]G 18.5 B:A[T>C]G 0.0 N:A[T>C]G 79.0 T:A[T>C]T 40.0 U:A[T>C]T 41.0 B:A[T>C]T 0.0 N:A[T>C]T 178.5 T:A[T>G]A 51.5 U:A[T>G]A 55.0 B:A[T>G]A 0.0 N:A[T>G]A 217.5 T:A[T>G]C 5.5 U:A[T>G]C 6.5 B:A[T>G]C 0.0 N:A[T>G]C 23.0 T:A[T>G]G 6.0 U:A[T>G]G 4.5 B:A[T>G]G 0.0 N:A[T>G]G 33.5 T:A[T>G]T 30.5 U:A[T>G]T 34.5 B:A[T>G]T 0.0 N:A[T>G]T 149.0 T:C[C>A]A 6.0 U:C[C>A]A 4.5 B:C[C>A]A 0.0 N:C[C>A]A 35.0 T:C[C>A]C 3.0 U:C[C>A]C 2.5 B:C[C>A]C 0.0 N:C[C>A]C 12.0 T:C[C>A]G 0.5 U:C[C>A]G 0.5 B:C[C>A]G 0.0 N:C[C>A]G 1.0 T:C[C>A]T 12.5 U:C[C>A]T 13.5 B:C[C>A]T 0.0 N:C[C>A]T 62.0 T:C[C>G]A 4.5 U:C[C>G]A 3.0 B:C[C>G]A 0.0 N:C[C>G]A 21.5 T:C[C>G]C 1.0 U:C[C>G]C 0.5 B:C[C>G]C 0.0 N:C[C>G]C 6.5 T:C[C>G]G 0.5 U:C[C>G]G 0.0 B:C[C>G]G 0.0 N:C[C>G]G 2.5 T:C[C>G]T 11.0 U:C[C>G]T 12.5 B:C[C>G]T 0.0 N:C[C>G]T 46.5 T:C[C>T]A 26.0 U:C[C>T]A 23.5 B:C[C>T]A 0.0 N:C[C>T]A 91.0 T:C[C>T]C 4.5 U:C[C>T]C 4.0 B:C[C>T]C 0.0 N:C[C>T]C 20.5 T:C[C>T]G 34.5 U:C[C>T]G 38.0 B:C[C>T]G 0.0 N:C[C>T]G 114.0 T:C[C>T]T 26.0 U:C[C>T]T 25.5 B:C[C>T]T 0.0 N:C[C>T]T 98.5 T:C[T>A]A 30.0 U:C[T>A]A 27.5 B:C[T>A]A 0.0 N:C[T>A]A 122.5 T:C[T>A]C 12.0 U:C[T>A]C 12.5 B:C[T>A]C 0.0 N:C[T>A]C 56.5 T:C[T>A]G 14.5 U:C[T>A]G 13.0 B:C[T>A]G 0.0 N:C[T>A]G 68.0 T:C[T>A]T 43.5 U:C[T>A]T 56.5 B:C[T>A]T 0.0 N:C[T>A]T 237.5 T:C[T>C]A 55.0 U:C[T>C]A 50.5 B:C[T>C]A 0.0 N:C[T>C]A 227.5 T:C[T>C]C 17.0 U:C[T>C]C 16.0 B:C[T>C]C 0.0 N:C[T>C]C 74.0 T:C[T>C]G 16.0 U:C[T>C]G 16.5 B:C[T>C]G 0.0 N:C[T>C]G 68.5 T:C[T>C]T 24.0 U:C[T>C]T 28.0 B:C[T>C]T 0.0 N:C[T>C]T 129.0 T:C[T>G]A 20.0 U:C[T>G]A 18.5 B:C[T>G]A 0.0 N:C[T>G]A 97.5 T:C[T>G]C 7.0 U:C[T>G]C 10.5 B:C[T>G]C 0.0 N:C[T>G]C 40.5 T:C[T>G]G 11.5 U:C[T>G]G 13.0 B:C[T>G]G 0.0 N:C[T>G]G 51.5 T:C[T>G]T 40.5 U:C[T>G]T 44.0 B:C[T>G]T 0.0 N:C[T>G]T 200.5 T:G[C>A]A 6.5 U:G[C>A]A 6.5 B:G[C>A]A 0.0 N:G[C>A]A 38.5 T:G[C>A]C 1.0 U:G[C>A]C 0.5 B:G[C>A]C 0.0 N:G[C>A]C 8.5 T:G[C>A]G 0.0 U:G[C>A]G 0.0 B:G[C>A]G 0.0 N:G[C>A]G 0.5 T:G[C>A]T 5.0 U:G[C>A]T 5.5 B:G[C>A]T 0.0 N:G[C>A]T 31.0 T:G[C>G]A 4.0 U:G[C>G]A 5.5 B:G[C>G]A 0.0 N:G[C>G]A 22.5 T:G[C>G]C 7.5 U:G[C>G]C 8.0 B:G[C>G]C 0.0 N:G[C>G]C 33.5 T:G[C>G]G 0.0 U:G[C>G]G 0.0 B:G[C>G]G 0.0 N:G[C>G]G 0.5 T:G[C>G]T 9.5 U:G[C>G]T 11.5 B:G[C>G]T 0.0 N:G[C>G]T 41.5 T:G[C>T]A 19.5 U:G[C>T]A 21.0 B:G[C>T]A 0.0 N:G[C>T]A 73.5 T:G[C>T]C 32.5 U:G[C>T]C 37.0 B:G[C>T]C 0.0 N:G[C>T]C 107.5 T:G[C>T]G 94.0 U:G[C>T]G 94.0 B:G[C>T]G 1.0 N:G[C>T]G 268.0 T:G[C>T]T 33.0 U:G[C>T]T 34.0 B:G[C>T]T 0.0 N:G[C>T]T 112.0 T:G[T>A]A 11.5 U:G[T>A]A 13.0 B:G[T>A]A 0.0 N:G[T>A]A 50.0 T:G[T>A]C 8.5 U:G[T>A]C 9.5 B:G[T>A]C 0.0 N:G[T>A]C 46.0 T:G[T>A]G 5.5 U:G[T>A]G 6.5 B:G[T>A]G 0.0 N:G[T>A]G 30.0 T:G[T>A]T 22.0 U:G[T>A]T 27.0 B:G[T>A]T 0.0 N:G[T>A]T 112.0 T:G[T>C]A 33.0 U:G[T>C]A 30.5 B:G[T>C]A 0.0 N:G[T>C]A 125.0 T:G[T>C]C 15.0 U:G[T>C]C 17.5 B:G[T>C]C 0.0 N:G[T>C]C 70.0 T:G[T>C]G 10.5 U:G[T>C]G 10.5 B:G[T>C]G 0.0 N:G[T>C]G 50.0 T:G[T>C]T 15.5 U:G[T>C]T 20.0 B:G[T>C]T 0.0 N:G[T>C]T 81.0 T:G[T>G]A 6.0 U:G[T>G]A 6.5 B:G[T>G]A 0.0 N:G[T>G]A 32.0 T:G[T>G]C 3.0 U:G[T>G]C 3.0 B:G[T>G]C 0.0 N:G[T>G]C 14.0 T:G[T>G]G 2.5 U:G[T>G]G 2.0 B:G[T>G]G 0.0 N:G[T>G]G 14.5 T:G[T>G]T 16.0 U:G[T>G]T 20.0 B:G[T>G]T 0.0 N:G[T>G]T 79.0 T:T[C>A]A 13.0 U:T[C>A]A 12.0 B:T[C>A]A 0.0 N:T[C>A]A 60.5 T:T[C>A]C 3.5 U:T[C>A]C 3.0 B:T[C>A]C 0.0 N:T[C>A]C 22.5 T:T[C>A]G 0.0 U:T[C>A]G 0.0 B:T[C>A]G 0.0 N:T[C>A]G 0.5 T:T[C>A]T 24.5 U:T[C>A]T 24.0 B:T[C>A]T 0.0 N:T[C>A]T 121.0 T:T[C>G]A 98.0 U:T[C>G]A 93.5 B:T[C>G]A 1.5 N:T[C>G]A 302.0 T:T[C>G]C 44.5 U:T[C>G]C 40.5 B:T[C>G]C 0.0 N:T[C>G]C 134.5 T:T[C>G]G 4.5 U:T[C>G]G 6.0 B:T[C>G]G 0.0 N:T[C>G]G 20.0 T:T[C>G]T 183.5 U:T[C>G]T 194.0 B:T[C>G]T 1.0 N:T[C>G]T 657.0 T:T[C>T]A 61.5 U:T[C>T]A 63.5 B:T[C>T]A 0.0 N:T[C>T]A 211.0 T:T[C>T]C 25.5 U:T[C>T]C 27.0 B:T[C>T]C 0.0 N:T[C>T]C 95.5 T:T[C>T]G 19.5 U:T[C>T]G 20.5 B:T[C>T]G 0.0 N:T[C>T]G 64.0 T:T[C>T]T 55.0 U:T[C>T]T 63.5 B:T[C>T]T 0.0 N:T[C>T]T 222.5 T:T[T>A]A 224.5 U:T[T>A]A 268.5 B:T[T>A]A 4.0 N:T[T>A]A 789.0 T:T[T>A]C 42.0 U:T[T>A]C 40.0 B:T[T>A]C 0.0 N:T[T>A]C 181.0 T:T[T>A]G 28.0 U:T[T>A]G 37.0 B:T[T>A]G 0.0 N:T[T>A]G 138.0 T:T[T>A]T 158.0 U:T[T>A]T 237.5 B:T[T>A]T 3.5 N:T[T>A]T 705.0 T:T[T>C]A 250.0 U:T[T>C]A 319.0 B:T[T>C]A 2.5 N:T[T>C]A 1183.5 T:T[T>C]C 100.5 U:T[T>C]C 106.5 B:T[T>C]C 1.5 N:T[T>C]C 423.5 T:T[T>C]G 57.5 U:T[T>C]G 74.5 B:T[T>C]G 0.5 N:T[T>C]G 290.5 T:T[T>C]T 150.5 U:T[T>C]T 179.0 B:T[T>C]T 1.0 N:T[T>C]T 608.5 T:T[T>G]A 131.0 U:T[T>G]A 180.5 B:T[T>G]A 0.5 N:T[T>G]A 702.0 T:T[T>G]C 36.5 U:T[T>G]C 45.5 B:T[T>G]C 0.0 N:T[T>G]C 156.5 T:T[T>G]G 50.5 U:T[T>G]G 61.0 B:T[T>G]G 0.5 N:T[T>G]G 225.5 T:T[T>G]T 251.5 U:T[T>G]T 345.5 B:T[T>G]T 3.0 N:T[T>G]T 1294.5 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type genic_real_count intergenic_real_count genic_mean_sims_count intergenic_mean_sims_count genic_versus_intergenic_p_value genic_versus_intergenic_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Transcribed_real_count Transcribed_mean_sims_count Transcribed_min_sims_count Transcribed_max_sims_count Transcribed_sims_count_list UnTranscribed_real_count UnTranscribed_mean_sims_count UnTranscribed_min_sims_count UnTranscribed_max_sims_count UnTranscribed_sims_count_list NonTranscribed_real_count NonTranscribed_mean_sims_count NonTranscribed_min_sims_count NonTranscribed_max_sims_count NonTranscribed_sims_count_list Ovary-AdenoCA SBS41 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3855.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS41 C>G 280.0 405.0 290.27 395.79 0.6218112312234845 1.0 17.769 3855.0 Intergenic 1.446 1.364 1.061 126.0 139.87 117.0 173.0 [124, 143, 138, 145, 135, 142, 144, 156, 147, 129, 131, 143, 144, 150, 159, 164, 148, 141, 142, 145, 152, 132, 136, 144, 141, 157, 145, 152, 143, 151, 147, 142, 127, 132, 143, 130, 138, 148, 139, 153, 143, 156, 131, 145, 135, 137, 133, 141, 138, 141, 139, 135, 124, 129, 122, 132, 143, 147, 173, 151, 151, 147, 153, 128, 142, 156, 137, 138, 125, 140, 148, 132, 138, 143, 141, 130, 140, 126, 147, 130, 121, 138, 138, 128, 127, 128, 125, 122, 147, 129, 147, 145, 138, 147, 117, 148, 132, 138, 136, 127] 154.0 150.4 117.0 177.0 [154, 152, 145, 141, 162, 148, 160, 117, 139, 156, 142, 156, 152, 164, 149, 160, 164, 132, 138, 148, 137, 155, 130, 161, 146, 137, 133, 153, 160, 157, 132, 153, 153, 175, 168, 133, 141, 156, 149, 156, 140, 129, 152, 162, 143, 144, 152, 134, 155, 151, 176, 159, 158, 155, 163, 153, 149, 149, 150, 137, 147, 147, 142, 163, 151, 154, 134, 156, 168, 143, 164, 163, 177, 149, 135, 162, 157, 156, 159, 154, 152, 157, 152, 154, 130, 138, 160, 145, 150, 149, 155, 147, 148, 152, 148, 138, 147, 168, 146, 148] 405.0 395.79 362.0 428.0 [405, 393, 402, 402, 389, 395, 380, 413, 400, 399, 412, 387, 390, 371, 376, 362, 376, 414, 405, 397, 397, 399, 417, 384, 400, 393, 408, 383, 386, 377, 409, 392, 408, 382, 376, 425, 406, 383, 397, 377, 402, 402, 402, 377, 409, 402, 401, 414, 394, 397, 373, 393, 401, 400, 402, 400, 392, 389, 366, 396, 386, 394, 390, 396, 391, 374, 415, 392, 390, 400, 381, 390, 372, 394, 409, 392, 392, 403, 382, 403, 412, 389, 397, 402, 428, 419, 400, 419, 391, 407, 384, 395, 401, 388, 418, 402, 406, 384, 402, 410] Ovary-AdenoCA SBS41 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3855.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS41 T>A 1130.0 1358.0 1029.28 1451.39 0.005497450968896833 0.020778158327593013 64.54 3855.0 Intergenic 1.202 1.41 0.852 529.0 483.06 438.0 529.0 [470, 483, 484, 481, 473, 466, 527, 510, 476, 472, 463, 505, 480, 469, 522, 491, 494, 455, 490, 475, 488, 482, 486, 465, 464, 455, 438, 504, 457, 478, 453, 482, 501, 502, 490, 485, 487, 508, 483, 497, 470, 458, 522, 484, 451, 497, 474, 478, 480, 482, 476, 511, 499, 499, 508, 477, 463, 489, 506, 476, 506, 484, 489, 471, 492, 485, 475, 458, 471, 488, 505, 495, 473, 480, 475, 488, 472, 490, 497, 486, 494, 479, 490, 451, 529, 448, 464, 478, 517, 518, 457, 462, 441, 475, 486, 505, 477, 498, 468, 498] 601.0 546.22 491.0 599.0 [595, 571, 559, 537, 583, 538, 591, 527, 517, 531, 577, 539, 553, 558, 543, 530, 555, 535, 501, 550, 527, 575, 567, 559, 552, 599, 557, 558, 550, 531, 538, 533, 549, 559, 566, 546, 538, 536, 544, 496, 567, 515, 543, 545, 559, 548, 540, 526, 557, 518, 543, 540, 516, 539, 514, 543, 548, 525, 536, 536, 519, 533, 543, 557, 550, 550, 525, 584, 551, 545, 564, 528, 525, 564, 572, 582, 553, 568, 562, 533, 499, 585, 549, 546, 538, 560, 558, 532, 507, 561, 544, 589, 550, 511, 555, 536, 491, 582, 558, 535] 1358.0 1451.39 1361.0 1515.0 [1417, 1428, 1437, 1462, 1423, 1477, 1361, 1442, 1487, 1478, 1441, 1436, 1448, 1452, 1413, 1463, 1436, 1488, 1488, 1453, 1469, 1423, 1429, 1457, 1465, 1427, 1490, 1424, 1469, 1473, 1486, 1463, 1431, 1423, 1424, 1456, 1461, 1440, 1450, 1485, 1443, 1506, 1416, 1449, 1469, 1435, 1467, 1474, 1442, 1478, 1458, 1435, 1465, 1446, 1462, 1466, 1469, 1462, 1442, 1467, 1454, 1470, 1449, 1451, 1445, 1446, 1480, 1438, 1460, 1443, 1417, 1464, 1483, 1433, 1434, 1412, 1455, 1423, 1420, 1456, 1487, 1417, 1439, 1483, 1413, 1469, 1460, 1469, 1458, 1405, 1477, 1427, 1489, 1497, 1442, 1436, 1515, 1397, 1450, 1450] Ovary-AdenoCA SBS41 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3855.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS41 T>G 292.0 390.0 285.09 398.63 0.7014760119766081 1.0 17.691 3855.0 Intergenic 1.336 1.398 0.955 115.0 127.06 108.0 145.0 [125, 137, 141, 138, 123, 139, 136, 133, 130, 129, 128, 124, 135, 125, 136, 123, 117, 125, 126, 123, 118, 124, 110, 134, 109, 125, 128, 135, 127, 131, 129, 130, 139, 121, 126, 129, 129, 119, 122, 130, 130, 132, 139, 127, 124, 119, 134, 124, 124, 132, 135, 131, 119, 121, 129, 122, 136, 142, 122, 123, 108, 124, 119, 127, 124, 115, 133, 114, 112, 138, 120, 123, 127, 133, 115, 115, 117, 121, 123, 139, 145, 130, 123, 124, 131, 122, 137, 137, 130, 129, 121, 123, 130, 125, 128, 136, 129, 125, 122, 139] 177.0 158.03 134.0 182.0 [164, 145, 146, 150, 171, 156, 159, 146, 159, 137, 146, 165, 147, 168, 157, 146, 136, 151, 168, 143, 150, 152, 166, 160, 176, 158, 149, 163, 152, 170, 161, 159, 143, 163, 169, 144, 138, 151, 159, 145, 150, 146, 154, 165, 155, 153, 158, 172, 147, 157, 164, 162, 157, 164, 150, 150, 153, 143, 172, 171, 146, 182, 169, 164, 172, 172, 158, 151, 175, 175, 155, 145, 169, 173, 162, 176, 156, 170, 178, 134, 147, 163, 161, 155, 147, 147, 149, 150, 177, 158, 162, 163, 146, 154, 160, 168, 165, 178, 163, 177] 390.0 398.63 368.0 430.0 [394, 402, 398, 394, 390, 386, 388, 406, 394, 417, 409, 395, 403, 391, 388, 416, 430, 405, 392, 419, 416, 408, 409, 391, 398, 401, 405, 387, 403, 383, 394, 396, 401, 400, 389, 410, 416, 416, 402, 408, 405, 408, 392, 396, 403, 413, 390, 389, 414, 395, 382, 392, 407, 396, 404, 411, 393, 397, 388, 391, 429, 381, 397, 392, 389, 395, 392, 420, 400, 369, 408, 415, 388, 378, 406, 390, 410, 392, 384, 411, 394, 389, 399, 405, 408, 413, 397, 397, 379, 398, 399, 398, 406, 403, 396, 380, 390, 382, 400, 368] Stomach-AdenoCA SBS41 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 11219.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS41 C>G 146.0 275.0 176.01 246.75 0.03980351474222195 0.12768081751400803 3.753 11219.0 Intergenic 1.884 1.402 1.344 1 1 1 79.0 85.04 66.0 112.0 [80, 82, 69, 83, 84, 77, 76, 90, 89, 90, 91, 83, 81, 85, 87, 86, 87, 91, 77, 90, 79, 80, 93, 95, 79, 84, 82, 66, 82, 103, 72, 86, 98, 79, 98, 72, 87, 92, 94, 82, 74, 80, 76, 92, 94, 93, 83, 85, 83, 83, 93, 76, 96, 74, 76, 83, 91, 91, 98, 83, 112, 79, 76, 86, 83, 100, 85, 92, 98, 72, 86, 96, 88, 89, 78, 79, 85, 90, 96, 83, 86, 79, 79, 83, 91, 79, 96, 76, 88, 87, 76, 72, 66, 96, 88, 99, 67, 85, 92, 81] 67.0 90.97 73.0 107.0 [105, 97, 102, 85, 89, 98, 96, 85, 99, 90, 84, 85, 92, 87, 105, 88, 98, 82, 93, 80, 94, 98, 92, 82, 101, 84, 102, 93, 100, 82, 87, 82, 79, 92, 73, 92, 95, 95, 99, 84, 101, 91, 92, 88, 104, 93, 86, 99, 100, 99, 80, 84, 100, 79, 98, 93, 78, 100, 79, 97, 99, 90, 83, 86, 96, 95, 98, 82, 107, 104, 92, 84, 79, 85, 85, 77, 85, 82, 91, 96, 83, 103, 94, 77, 74, 92, 92, 88, 83, 78, 99, 99, 91, 92, 93, 105, 101, 90, 97, 83] 275.0 246.75 212.0 269.0 [238, 243, 252, 254, 248, 246, 253, 249, 237, 245, 247, 255, 248, 249, 231, 248, 238, 250, 253, 252, 251, 246, 238, 249, 241, 254, 241, 263, 240, 236, 267, 254, 246, 253, 253, 258, 240, 236, 229, 256, 248, 251, 257, 242, 226, 237, 255, 239, 240, 241, 250, 263, 226, 269, 248, 246, 252, 230, 244, 242, 212, 254, 263, 251, 244, 228, 240, 247, 218, 247, 246, 244, 255, 250, 261, 265, 251, 250, 237, 243, 253, 241, 252, 262, 259, 252, 235, 259, 250, 261, 246, 253, 265, 236, 240, 220, 253, 247, 233, 259] Stomach-AdenoCA SBS41 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 11219.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS41 T>A 2055.0 3789.0 2408.11 3441.14 2.3363817558553412e-11 1.5226903242745796e-10 52.09 11219.0 Intergenic 1.844 1.429 1.29 1 1 984.0 1142.42 1071.0 1210.0 [1135, 1085, 1155, 1105, 1166, 1120, 1171, 1185, 1149, 1154, 1122, 1177, 1144, 1138, 1071, 1100, 1119, 1129, 1144, 1154, 1089, 1161, 1137, 1159, 1183, 1200, 1154, 1165, 1093, 1184, 1118, 1135, 1086, 1151, 1105, 1086, 1144, 1171, 1091, 1143, 1076, 1180, 1147, 1117, 1125, 1137, 1210, 1164, 1166, 1163, 1158, 1143, 1171, 1148, 1130, 1127, 1132, 1147, 1174, 1138, 1188, 1180, 1150, 1157, 1144, 1146, 1165, 1183, 1127, 1134, 1117, 1093, 1171, 1129, 1097, 1093, 1115, 1153, 1196, 1156, 1181, 1182, 1146, 1151, 1133, 1139, 1151, 1132, 1163, 1139, 1116, 1145, 1119, 1164, 1113, 1160, 1134, 1164, 1181, 1104] 1071.0 1265.69 1193.0 1349.0 [1261, 1263, 1336, 1305, 1207, 1305, 1263, 1210, 1305, 1268, 1265, 1240, 1282, 1253, 1297, 1251, 1262, 1349, 1252, 1243, 1242, 1297, 1278, 1247, 1232, 1264, 1265, 1255, 1279, 1236, 1239, 1263, 1278, 1307, 1280, 1288, 1287, 1231, 1295, 1278, 1306, 1236, 1280, 1323, 1311, 1309, 1249, 1230, 1279, 1291, 1302, 1273, 1241, 1251, 1259, 1288, 1281, 1254, 1278, 1271, 1297, 1245, 1229, 1297, 1222, 1248, 1289, 1251, 1269, 1258, 1324, 1248, 1295, 1193, 1301, 1268, 1282, 1215, 1246, 1243, 1240, 1261, 1254, 1265, 1270, 1251, 1248, 1239, 1247, 1258, 1253, 1215, 1293, 1300, 1269, 1285, 1231, 1268, 1203, 1229] 3789.0 3441.14 3356.0 3527.0 [3451, 3499, 3356, 3438, 3466, 3423, 3416, 3455, 3402, 3440, 3458, 3433, 3431, 3467, 3476, 3488, 3466, 3378, 3452, 3449, 3520, 3384, 3431, 3446, 3431, 3382, 3427, 3431, 3489, 3438, 3489, 3451, 3482, 3401, 3469, 3470, 3418, 3445, 3462, 3424, 3472, 3429, 3428, 3412, 3408, 3408, 3384, 3449, 3401, 3395, 3384, 3428, 3446, 3452, 3457, 3431, 3427, 3447, 3393, 3434, 3366, 3427, 3474, 3398, 3480, 3458, 3403, 3417, 3443, 3465, 3424, 3508, 3378, 3527, 3449, 3499, 3448, 3480, 3402, 3454, 3429, 3401, 3446, 3432, 3445, 3466, 3450, 3475, 3447, 3454, 3473, 3491, 3431, 3389, 3468, 3410, 3493, 3416, 3465, 3514] Stomach-AdenoCA SBS41 T>C 837.0 1769.0 1080.32 1531.56 4.339663361398841e-12 2.9122645871240085e-11 23.228 11219.0 Intergenic 2.114 1.418 1.491 1 1 1 360.0 516.89 457.0 578.0 [504, 519, 531, 511, 527, 502, 491, 512, 515, 507, 525, 556, 496, 513, 578, 526, 534, 542, 465, 539, 527, 490, 535, 519, 515, 524, 498, 492, 464, 481, 543, 492, 557, 558, 539, 496, 539, 508, 505, 532, 515, 500, 514, 523, 503, 499, 540, 529, 527, 492, 516, 550, 538, 519, 523, 544, 518, 513, 538, 518, 493, 549, 510, 511, 542, 510, 484, 487, 491, 511, 518, 468, 502, 512, 505, 525, 511, 525, 497, 516, 484, 505, 537, 535, 538, 485, 531, 525, 526, 522, 522, 509, 516, 537, 457, 513, 557, 532, 539, 526] 477.0 563.43 514.0 612.0 [585, 589, 563, 558, 547, 583, 580, 594, 571, 545, 571, 558, 546, 558, 552, 591, 537, 555, 599, 542, 574, 560, 561, 542, 576, 561, 550, 584, 566, 538, 575, 561, 551, 549, 568, 587, 568, 523, 550, 547, 544, 581, 602, 577, 550, 530, 567, 534, 544, 586, 559, 575, 526, 567, 524, 603, 531, 575, 514, 588, 552, 568, 546, 573, 552, 577, 581, 577, 571, 567, 554, 588, 580, 570, 591, 560, 526, 552, 581, 536, 612, 576, 564, 548, 556, 561, 575, 559, 557, 542, 567, 555, 584, 531, 594, 574, 582, 588, 558, 566] 1769.0 1531.56 1469.0 1593.0 [1518, 1504, 1523, 1537, 1532, 1528, 1545, 1503, 1530, 1558, 1518, 1501, 1573, 1544, 1479, 1492, 1544, 1522, 1544, 1530, 1511, 1562, 1517, 1551, 1519, 1527, 1564, 1539, 1580, 1593, 1497, 1560, 1501, 1505, 1505, 1526, 1502, 1579, 1558, 1529, 1551, 1539, 1500, 1510, 1556, 1581, 1506, 1546, 1546, 1531, 1542, 1486, 1547, 1527, 1568, 1469, 1559, 1526, 1560, 1508, 1564, 1492, 1555, 1531, 1525, 1526, 1545, 1546, 1550, 1536, 1538, 1556, 1529, 1530, 1515, 1527, 1570, 1545, 1530, 1563, 1516, 1529, 1517, 1529, 1513, 1566, 1514, 1524, 1528, 1546, 1517, 1548, 1504, 1545, 1561, 1525, 1474, 1488, 1514, 1517] Stomach-AdenoCA SBS41 T>G 725.0 1623.0 982.52 1371.94 9.770187978731887e-15 7.197711495935402e-14 20.929 11219.0 Intergenic 2.239 1.396 1.603 1 1 1 1 304.0 470.15 432.0 519.0 [466, 490, 469, 481, 472, 482, 460, 470, 464, 460, 492, 473, 471, 482, 456, 469, 460, 480, 482, 455, 487, 491, 491, 432, 436, 466, 455, 499, 468, 443, 508, 446, 489, 465, 449, 477, 484, 449, 457, 473, 470, 459, 453, 478, 475, 458, 450, 452, 483, 497, 497, 449, 464, 443, 500, 451, 504, 475, 472, 499, 482, 462, 454, 461, 485, 452, 471, 509, 460, 478, 458, 478, 467, 482, 441, 465, 478, 451, 462, 470, 455, 456, 519, 489, 457, 462, 483, 454, 475, 432, 480, 507, 472, 449, 475, 448, 512, 464, 467, 465] 421.0 512.37 463.0 559.0 [525, 473, 525, 500, 510, 505, 477, 530, 495, 516, 511, 514, 493, 488, 542, 512, 512, 516, 547, 493, 518, 500, 499, 559, 543, 508, 507, 491, 463, 532, 503, 533, 499, 518, 526, 521, 512, 518, 525, 471, 525, 517, 533, 504, 546, 521, 530, 488, 547, 506, 541, 487, 516, 521, 475, 505, 524, 495, 522, 497, 504, 530, 507, 513, 473, 557, 504, 518, 529, 525, 517, 538, 515, 494, 506, 509, 528, 516, 529, 518, 524, 538, 496, 516, 510, 527, 535, 512, 490, 520, 497, 522, 480, 518, 508, 498, 481, 516, 518, 471] 1623.0 1371.94 1316.0 1422.0 [1356, 1399, 1364, 1377, 1369, 1370, 1420, 1358, 1398, 1381, 1354, 1368, 1389, 1384, 1359, 1368, 1380, 1363, 1325, 1410, 1347, 1365, 1366, 1364, 1372, 1387, 1389, 1364, 1422, 1382, 1346, 1377, 1366, 1372, 1377, 1356, 1355, 1389, 1368, 1406, 1358, 1377, 1366, 1376, 1337, 1380, 1373, 1416, 1332, 1350, 1316, 1416, 1374, 1393, 1379, 1397, 1327, 1384, 1359, 1361, 1366, 1363, 1389, 1378, 1396, 1346, 1379, 1329, 1367, 1345, 1386, 1338, 1369, 1378, 1410, 1383, 1351, 1386, 1365, 1363, 1371, 1359, 1341, 1352, 1388, 1363, 1334, 1384, 1387, 1407, 1378, 1325, 1400, 1388, 1370, 1409, 1360, 1372, 1369, 1417] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS41 T>A Intergenic ['Stomach-AdenoCA'] 1 ['Stomach-AdenoCA'] 1 [] 0 [] 0 [] 0 [] 0 ['Ovary-AdenoCA', 'Stomach-AdenoCA'] 2 1.2 SBS41 T>C Intergenic ['Stomach-AdenoCA'] 1 ['Stomach-AdenoCA'] 1 ['Stomach-AdenoCA'] 1 [] 0 [] 0 [] 0 ['Ovary-AdenoCA', 'Stomach-AdenoCA'] 2 1.3 SBS41 T>G Intergenic ['Stomach-AdenoCA'] 1 ['Stomach-AdenoCA'] 1 ['Stomach-AdenoCA'] 1 ['Stomach-AdenoCA'] 1 [] 0 [] 0 ['Ovary-AdenoCA', 'Stomach-AdenoCA'] 2 1.5