# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type cutoff number_of_mutations average_probability file_name pearson_corr pearson_p_value pearson_q_value real_average_number_of_overlaps sims_average_number_of_overlaps avg_real_signal sim_data_avg_signal fold_change real_average_signal_array sims_average_signal_array SBS40 ALL 0.53 5115 0.753 SBS40_ENCFF449NOT_B-cell_Normal_CTCF-human_AverageSignalArray.txt 41.3 31.268 202.554 182.953 1.107 [205.548, 205.548, 205.548, 205.548, 205.548, 205.548, 205.548, 205.548, 205.548, 205.548, 205.548, 199.137, 190.423, 187.94, 187.94, 187.94, 187.94, 188.328, 188.328, 188.328, 188.328, 188.328, 188.328, 186.297, 188.016, 188.016, 188.016, 188.016, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 184.833, 190.873, 190.873, 190.873, 190.873, 190.873, 190.873, 185.39, 185.39, 185.39, 185.39, 185.39, 180.653, 180.653, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 187.991, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 182.484, 188.025, 188.025, 188.025, 188.025, 188.295, 188.295, 188.295, 187.677, 187.677, 187.677, 187.677, 187.677, 188.226, 193.883, 193.883, 193.883, 189.232, 189.232, 189.232, 189.232, 189.232, 189.232, 186.652, 186.652, 186.652, 186.652, 186.652, 186.652, 186.652, 186.652, 186.652, 186.652, 186.652, 185.518, 185.518, 185.518, 185.518, 185.518, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 186.654, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 191.258, 201.791, 207.402, 207.402, 207.402, 207.402, 207.402, 207.402, 207.402, 207.402, 207.402, 207.402, 202.195, 197.473, 197.473, 197.473, 191.988, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.229, 184.493, 184.493, 180.371, 181.923, 181.923, 181.923, 181.923, 181.923, 181.923, 181.923, 181.923, 190.319, 190.319, 190.319, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 204.453, 207.156, 201.912, 215.661, 215.661, 215.661, 215.661, 215.661, 215.661, 215.661, 215.661, 215.661, 215.661, 220.228, 220.228, 220.228, 220.228, 220.228, 220.228, 221.184, 221.184, 221.184, 221.184, 224.11, 224.11, 221.124, 221.124, 221.124, 221.124, 221.124, 221.124, 221.124, 221.124, 221.124, 227.025, 227.025, 227.025, 227.025, 227.025, 227.025, 227.025, 227.025, 227.025, 229.264, 229.264, 229.264, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 227.538, 224.716, 224.716, 233.539, 233.539, 236.9, 240.589, 240.589, 245.858, 245.858, 246.576, 246.576, 246.576, 246.576, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 250.795, 253.183, 253.183, 253.183, 246.446, 240.893, 240.893, 240.893, 240.893, 240.893, 240.893, 240.893, 240.893, 240.893, 240.893, 240.893, 237.377, 237.377, 237.377, 237.377, 237.377, 237.377, 237.377, 237.377, 234.394, 234.394, 234.394, 234.394, 234.394, 234.394, 234.394, 229.532, 229.532, 229.532, 229.532, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 226.559, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 216.704, 214.014, 214.016, 214.016, 214.016, 214.016, 214.016, 214.016, 214.016, 214.016, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 214.233, 218.639, 218.639, 217.964, 221.986, 216.889, 216.889, 216.889, 216.889, 216.889, 212.552, 212.552, 212.552, 209.263, 209.263, 209.263, 209.263, 204.81, 204.81, 200.488, 200.488, 200.488, 204.872, 204.872, 204.872, 204.872, 203.177, 203.177, 203.177, 203.177, 197.128, 197.128, 195.234, 195.234, 195.234, 195.234, 195.234, 195.234, 195.234, 195.234, 195.234, 195.234, 195.234, 198.861, 198.861, 198.861, 198.861, 198.861, 198.861, 198.861, 198.861, 204.435, 204.435, 204.435, 204.435, 204.435, 204.435, 204.435, 204.415, 204.415, 204.415, 204.415, 204.415, 204.415, 204.415, 208.824, 208.824, 208.426, 208.426, 208.426, 208.426, 208.426, 203.958, 203.958, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 199.936, 201.007, 201.007, 201.007, 201.007, 201.007, 201.007, 201.007, 205.164, 205.164, 205.164, 205.164, 205.164, 205.164, 206.201, 205.185, 205.185, 205.185, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 207.65, 202.939, 202.939, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 207.581, 199.647, 199.647, 199.647, 199.647, 195.34, 195.34, 195.34, 195.34, 195.34, 190.883, 190.883, 190.883, 195.569, 195.569, 195.569, 193.358, 193.358, 193.358, 193.358, 193.358, 193.358, 193.358, 193.358, 193.358, 197.161, 197.161, 197.161, 197.161, 197.161, 197.161, 197.161, 197.161, 197.161, 199.711, 205.616, 205.616, 205.616, 205.616, 205.616, 205.616, 205.616, 205.616, 205.616, 205.616, 201.704, 201.704, 205.944, 205.944, 207.975, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 208.985, 204.315, 204.315, 204.315, 204.315, 204.315, 204.315, 204.315, 204.315, 204.315, 204.315, 204.491, 204.491, 204.491, 204.491, 199.862, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 207.335, 209.242, 209.242, 209.242, 209.242, 209.242, 209.242, 209.242, 209.242, 209.3, 209.3, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 213.823, 216.306, 216.306, 223.605, 223.605, 223.605, 223.605, 223.605, 223.605, 227.617, 232.552, 232.552, 232.552, 232.552, 230.653, 230.653, 230.653, 230.653, 230.653, 230.653, 230.653, 230.653, 230.653, 235.939, 231.716, 231.716, 231.716, 231.716, 231.716, 231.716, 231.716, 231.716, 223.7, 223.7, 223.7, 222.814, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.386, 225.708, 220.627, 220.627, 220.627, 220.627, 210.1, 210.1, 210.1, 210.1, 210.1, 210.1, 210.1, 210.1, 210.1, 210.1, 210.1, 210.66, 210.66, 210.66, 210.66, 210.66, 210.66, 210.66, 210.66, 199.751, 199.751, 199.751, 194.381, 181.227, 181.227, 181.227, 181.227, 181.227, 181.227, 181.227, 181.227, 181.227, 176.302, 176.302, 176.302, 176.302, 176.302, 176.302, 176.302, 176.302, 171.63, 171.63, 171.63, 171.63, 171.63, 171.63, 179.568, 179.568, 179.568, 179.568, 184.662, 184.662, 179.981, 179.981, 190.621, 196.085, 196.085, 196.085, 196.085, 196.085, 196.085, 192.501, 192.501, 173.291, 173.291, 173.291, 162.182, 162.182, 162.182, 162.182, 164.081, 164.081, 164.081, 167.599, 167.599, 167.599, 167.599, 167.599, 167.599, 171.51, 171.51, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 176.945, 162.329, 162.329, 162.329, 162.329, 160.945, 160.945, 160.945, 160.945, 160.945, 160.945, 160.945, 160.945, 160.945, 160.945, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 174.584, 171.838, 171.838, 171.838, 171.838, 178.365, 178.365, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 180.322, 184.142, 178.528, 178.528, 178.528, 176.379, 176.379, 182.1, 182.1, 182.1, 182.1, 182.1, 176.444, 176.444, 176.444, 176.444, 176.444, 172.193, 172.193, 172.193, 172.193, 172.193, 168.37, 168.37, 168.37, 168.641, 168.641, 163.623, 163.623, 163.623, 163.623, 163.97, 159.729, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 163.722, 155.216, 155.216, 155.216, 155.216, 155.216, 155.216, 155.216, 155.216, 159.549, 154.883, 158.879, 158.879, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796, 154.796] [181.644, 181.806, 181.757, 181.456, 181.142, 181.073, 181.298, 181.044, 180.78, 180.555, 180.248, 180.442, 180.545, 180.475, 180.027, 180.085, 180.071, 179.909, 180.01, 180.391, 180.431, 180.528, 180.361, 180.305, 180.346, 180.776, 180.966, 180.866, 180.427, 180.963, 180.436, 180.907, 180.933, 180.791, 181.006, 181.12, 181.092, 181.322, 181.458, 181.529, 181.859, 182.004, 182.075, 182.305, 182.281, 182.459, 182.37, 182.127, 182.256, 182.544, 182.691, 182.753, 182.885, 183.074, 183.144, 182.914, 183.089, 183.126, 182.896, 182.916, 182.801, 182.632, 182.589, 182.261, 182.585, 182.32, 182.433, 182.634, 182.81, 182.881, 183.063, 183.174, 183.082, 182.789, 183.105, 182.824, 182.478, 182.364, 182.194, 182.379, 182.478, 182.579, 182.652, 182.662, 182.765, 182.508, 182.397, 182.181, 182.388, 182.329, 182.407, 182.647, 182.885, 182.324, 182.548, 182.511, 182.358, 182.307, 181.914, 182.115, 181.951, 181.62, 181.499, 181.377, 181.485, 181.806, 181.569, 181.647, 181.696, 181.962, 181.951, 182.012, 182.153, 182.248, 182.252, 182.177, 182.572, 182.655, 182.968, 183.073, 183.064, 183.17, 182.987, 183.253, 183.346, 183.265, 183.373, 183.157, 182.725, 182.697, 182.342, 182.358, 182.389, 182.104, 181.85, 181.812, 181.837, 181.874, 182.182, 181.96, 181.791, 182.097, 182.193, 182.215, 182.234, 182.167, 181.973, 181.922, 181.994, 182.291, 182.289, 182.466, 182.886, 182.718, 182.855, 183.145, 183.163, 183.032, 182.884, 182.792, 183.003, 183.02, 183.243, 183.144, 183.233, 183.328, 183.43, 183.186, 183.117, 183.075, 183.336, 183.395, 183.286, 183.256, 183.444, 183.302, 183.556, 183.467, 183.336, 183.27, 183.261, 183.658, 183.928, 184.093, 184.076, 183.95, 183.993, 184.194, 184.427, 184.698, 184.595, 184.731, 185.091, 185.062, 185.191, 184.898, 184.994, 185.229, 185.263, 185.056, 184.827, 184.617, 184.428, 184.733, 184.794, 184.575, 184.424, 184.449, 184.436, 184.062, 183.928, 184.049, 183.906, 183.762, 183.292, 183.395, 182.999, 182.913, 182.991, 183.002, 183.032, 182.896, 182.927, 182.618, 182.454, 182.24, 182.431, 182.635, 182.82, 182.574, 182.517, 182.726, 182.59, 182.188, 182.316, 182.469, 182.408, 182.157, 182.046, 182.16, 182.001, 182.324, 182.153, 182.254, 182.105, 182.307, 182.074, 182.202, 182.017, 181.959, 181.878, 182.057, 182.052, 182.482, 182.289, 181.998, 181.914, 181.605, 181.544, 181.75, 181.617, 181.51, 181.256, 181.044, 181.021, 181.025, 181.454, 181.149, 181.278, 181.191, 180.888, 181.025, 181.082, 180.822, 180.628, 180.287, 180.52, 180.466, 180.382, 180.316, 180.463, 180.638, 180.802, 180.154, 179.795, 179.654, 179.527, 179.266, 179.399, 179.362, 179.529, 179.369, 179.411, 179.12, 179.364, 179.596, 179.65, 179.517, 179.474, 179.62, 179.492, 179.665, 179.777, 179.775, 180.214, 180.255, 180.1, 180.371, 180.553, 180.189, 179.953, 180.118, 179.767, 179.722, 179.702, 179.566, 179.498, 179.396, 179.64, 179.282, 179.276, 179.594, 179.973, 180.01, 179.95, 180.343, 180.105, 179.663, 179.828, 180.075, 180.157, 180.0, 179.612, 179.707, 179.634, 179.824, 179.52, 179.987, 180.411, 180.429, 180.043, 180.143, 180.077, 179.901, 179.858, 179.495, 178.971, 179.22, 179.327, 179.49, 179.444, 179.262, 179.182, 178.953, 178.831, 178.811, 178.987, 178.996, 178.823, 179.292, 179.543, 179.803, 179.65, 179.47, 179.503, 179.454, 179.806, 180.066, 180.114, 179.78, 180.018, 179.841, 179.767, 179.758, 179.792, 179.649, 179.851, 179.736, 179.712, 179.597, 179.462, 179.472, 179.585, 179.801, 180.004, 180.136, 180.304, 180.568, 180.257, 180.16, 180.248, 180.547, 180.504, 180.408, 180.397, 180.587, 181.288, 181.219, 181.242, 181.257, 180.975, 181.165, 181.467, 181.569, 181.224, 181.115, 181.014, 181.31, 181.445, 181.523, 181.52, 181.667, 181.722, 181.463, 181.71, 181.692, 181.859, 181.679, 182.063, 182.21, 182.591, 182.522, 182.698, 182.637, 182.556, 182.19, 182.181, 182.07, 182.118, 181.887, 182.134, 182.342, 182.544, 182.349, 182.089, 181.743, 181.444, 181.325, 181.349, 181.703, 181.757, 181.851, 181.971, 181.843, 181.748, 181.509, 181.456, 181.434, 181.61, 181.542, 181.39, 181.376, 181.581, 181.445, 181.579, 181.379, 181.494, 181.421, 181.362, 181.484, 181.533, 181.438, 181.588, 181.667, 181.639, 181.752, 181.832, 181.928, 181.917, 182.034, 182.228, 182.409, 182.48, 182.312, 182.053, 182.022, 182.034, 181.869, 182.201, 182.245, 182.124, 182.153, 182.373, 182.652, 182.99, 183.254, 183.201, 182.795, 182.659, 182.225, 182.463, 182.553, 182.648, 182.782, 182.686, 182.73, 182.543, 182.633, 182.875, 182.442, 182.484, 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