# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS3 Bone-Osteosarc [421, 444, 456, 522, 579, 710, 744, 862, 1082, 482] [0.338, 0.357, 0.366, 0.42, 0.465, 0.572, 0.6, 0.697, 0.877, 1.0] [0.978, 0.957, 0.95, 0.945, 0.929, 0.917, 0.91, 0.91, 0.924, 0.931] 0.072 0.662 0.52 INC 0.67 6316 0.754 SBS3 CNS-Medullo [375, 496, 635, 674, 767, 718, 694, 795, 776, 286] [0.469, 0.62, 0.793, 0.842, 0.958, 0.899, 0.87, 1.0, 0.981, 0.931] [0.896, 0.928, 0.955, 0.954, 0.965, 0.962, 0.926, 0.929, 0.908, 0.894] 0.047 0.531 0.362 INC 0.5 6260 0.778 SBS3 Head-SCC [1097, 1183, 1335, 1505, 1758, 2018, 2328, 2640, 3048, 1322] [0.321, 0.346, 0.391, 0.441, 0.515, 0.593, 0.684, 0.778, 0.9, 1.0] [0.975, 0.979, 0.975, 0.962, 0.966, 0.949, 0.939, 0.937, 0.917, 0.909] 0.077 0.679 0.554 INC 0.64 18249 0.757 SBS3 Lung-AdenoCA [616, 722, 683, 738, 711, 845, 935, 1009, 1053, 459] [0.529, 0.619, 0.587, 0.634, 0.613, 0.728, 0.805, 0.876, 0.914, 1.0] [0.968, 0.962, 0.965, 0.952, 0.94, 0.932, 0.929, 0.9, 0.914, 0.897] 0.051 0.471 0.328 INC 0.61 7800 0.752 SBS3 Panc-AdenoCA [8514, 8306, 8552, 9071, 10096, 11285, 12311, 13213, 14957, 6260] [0.527, 0.514, 0.529, 0.562, 0.625, 0.7, 0.764, 0.823, 0.933, 1.0] [1.0, 0.965, 0.952, 0.941, 0.924, 0.918, 0.909, 0.903, 0.887, 0.877] 0.057 0.486 0.406 INC 0.65 103324 0.755 SBS3 Prost-AdenoCA [505, 511, 481, 516, 506, 584, 766, 747, 702, 316] [0.619, 0.626, 0.589, 0.633, 0.62, 0.718, 0.942, 0.921, 0.868, 1.0] [0.991, 0.953, 0.923, 0.888, 0.871, 0.865, 0.852, 0.843, 0.829, 0.83] 0.047 0.411 0.303 INC 0.69 5654 0.759 SBS3 Stomach-AdenoCA [9553, 9964, 10979, 11945, 13911, 15854, 17113, 18684, 20623, 8650] [0.428, 0.446, 0.491, 0.535, 0.623, 0.712, 0.769, 0.842, 0.931, 1.0] [0.988, 0.994, 0.994, 0.984, 0.98, 0.976, 0.966, 0.959, 0.943, 0.933] 0.067 0.572 0.485 INC 0.6 137578 0.752 SBS3 Uterus-AdenoCA [718, 802, 837, 974, 1007, 1217, 1200, 1360, 1459, 602] [0.467, 0.521, 0.544, 0.634, 0.657, 0.795, 0.785, 0.893, 0.961, 1.0] [0.913, 0.942, 0.962, 0.965, 0.965, 0.964, 0.958, 0.946, 0.944, 0.937] 0.062 0.533 0.439 INC 0.5 10176 0.777 SBS3 Breast-Cancer [96172, 99724, 105276, 110478, 116992, 125724, 133154, 140447, 151612, 62497] [0.596, 0.618, 0.652, 0.685, 0.725, 0.782, 0.828, 0.876, 0.947, 1.0] [1.0, 0.984, 0.975, 0.977, 0.968, 0.965, 0.959, 0.955, 0.962, 0.957] 0.046 0.404 0.33 INC 0.5 1142172 0.771 SBS3 Eso-AdenoCA [1700, 1814, 2048, 2270, 2800, 3266, 3717, 4256, 4799, 2155] [0.305, 0.326, 0.368, 0.408, 0.503, 0.589, 0.67, 0.77, 0.87, 1.0] [0.987, 0.982, 0.983, 0.964, 0.956, 0.933, 0.923, 0.923, 0.906, 0.897] 0.078 0.695 0.544 INC 0.68 28842 0.755 SBS3 ESCC [24799, 26835, 30662, 34850, 40775, 48214, 54418, 59611, 67336, 30113] [0.319, 0.345, 0.394, 0.449, 0.525, 0.622, 0.702, 0.772, 0.873, 1.0] [0.968, 0.985, 0.998, 0.996, 0.988, 0.985, 0.981, 0.972, 0.96, 0.96] 0.076 0.681 0.528 INC 0.63 419144 0.752 SBS3 Liver-HCC [235, 248, 264, 362, 376, 459, 600, 572, 754, 313] [0.297, 0.313, 0.334, 0.458, 0.476, 0.583, 0.764, 0.731, 0.96, 1.0] [0.978, 0.952, 0.942, 0.94, 0.912, 0.892, 0.87, 0.858, 0.822, 0.82] 0.084 0.703 0.647 INC 0.72 4191 0.756 SBS3 Ovary-AdenoCA [32886, 33739, 36068, 39763, 43121, 49579, 51584, 55409, 60306, 26075] [0.494, 0.506, 0.542, 0.597, 0.649, 0.748, 0.779, 0.84, 0.917, 1.0] [0.998, 0.991, 0.994, 0.995, 0.988, 0.978, 0.971, 0.965, 0.962, 0.955] 0.058 0.506 0.41 INC 0.6 428549 0.755 SBS3 Panc-Endocrine [578, 607, 689, 762, 814, 962, 1064, 1262, 1476, 625] [0.358, 0.376, 0.427, 0.473, 0.505, 0.598, 0.662, 0.787, 0.922, 1.0] [0.962, 0.948, 0.95, 0.952, 0.955, 0.943, 0.933, 0.954, 0.962, 0.927] 0.073 0.642 0.546 INC 0.67 8871 0.751 SBS3 ACROSS_ALL_CANCER_TYPES [0.435, 0.469, 0.503, 0.558, 0.607, 0.692, 0.763, 0.833, 0.923, 1.0] [0.972, 0.966, 0.966, 0.958, 0.95, 0.942, 0.93, 0.925, 0.917, 0.909] 14 0 0 14