# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 2382.176 E:A[C>A]A 2514.533 A:A[C>G]A 1891.503 E:A[C>G]A 1848.246 A:A[C>T]A 1457.402 E:A[C>T]A 1464.562 A:A[T>A]A 900.053 E:A[T>A]A 927.389 A:A[T>C]A 1483.356 E:A[T>C]A 1520.951 A:A[T>G]A 603.776 E:A[T>G]A 597.612 A:A[C>A]C 1978.454 E:A[C>A]C 2086.642 A:A[C>G]C 1084.754 E:A[C>G]C 1076.974 A:A[C>T]C 1015.879 E:A[C>T]C 1024.212 A:A[T>A]C 805.654 E:A[T>A]C 847.763 A:A[T>C]C 788.42 E:A[T>C]C 812.393 A:A[T>G]C 266.729 E:A[T>G]C 271.544 A:A[C>A]G 270.206 E:A[C>A]G 275.035 A:A[C>G]G 125.778 E:A[C>G]G 129.719 A:A[C>T]G 249.251 E:A[C>T]G 253.741 A:A[T>A]G 1025.351 E:A[T>A]G 1044.212 A:A[T>C]G 976.113 E:A[T>C]G 966.467 A:A[T>G]G 638.965 E:A[T>G]G 643.996 A:A[C>A]T 1892.88 E:A[C>A]T 1939.503 A:A[C>G]T 1904.513 E:A[C>G]T 1779.153 A:A[C>T]T 1403.371 E:A[C>T]T 1426.335 A:A[T>A]T 1314.739 E:A[T>A]T 1334.398 A:A[T>C]T 1614.222 E:A[T>C]T 1609.715 A:A[T>G]T 635.474 E:A[T>G]T 605.394 A:C[C>A]A 2289.819 E:C[C>A]A 2387.71 A:C[C>G]A 1385.159 E:C[C>G]A 1383.232 A:C[C>T]A 1720.749 E:C[C>T]A 1704.379 A:C[T>A]A 1058.274 E:C[T>A]A 1108.06 A:C[T>C]A 926.291 E:C[T>C]A 938.311 A:C[T>G]A 477.238 E:C[T>G]A 484.262 A:C[C>A]C 2103.451 E:C[C>A]C 2220.059 A:C[C>G]C 1038.541 E:C[C>G]C 1049.515 A:C[C>T]C 1572.737 E:C[C>T]C 1580.136 A:C[T>A]C 1448.413 E:C[T>A]C 1492.25 A:C[T>C]C 1364.777 E:C[T>C]C 1374.568 A:C[T>G]C 545.787 E:C[T>G]C 548.55 A:C[C>A]G 255.928 E:C[C>A]G 257.509 A:C[C>G]G 270.267 E:C[C>G]G 266.009 A:C[C>T]G 209.621 E:C[C>T]G 205.982 A:C[T>A]G 1483.778 E:C[T>A]G 1475.19 A:C[T>C]G 839.296 E:C[T>C]G 823.681 A:C[T>G]G 940.406 E:C[T>G]G 928.154 A:C[C>A]T 2131.184 E:C[C>A]T 2093.577 A:C[C>G]T 1900.54 E:C[C>G]T 1765.736 A:C[C>T]T 2281.368 E:C[C>T]T 2218.342 A:C[T>A]T 1971.916 E:C[T>A]T 1944.928 A:C[T>C]T 1512.235 E:C[T>C]T 1462.857 A:C[T>G]T 1000.986 E:C[T>G]T 949.936 A:G[C>A]A 1055.284 E:G[C>A]A 1075.16 A:G[C>G]A 928.341 E:G[C>G]A 905.325 A:G[C>T]A 1591.902 E:G[C>T]A 1543.667 A:G[T>A]A 679.466 E:G[T>A]A 683.033 A:G[T>C]A 1063.551 E:G[T>C]A 1046.035 A:G[T>G]A 381.865 E:G[T>G]A 379.969 A:G[C>A]C 1237.952 E:G[C>A]C 1242.596 A:G[C>G]C 815.979 E:G[C>G]C 809.422 A:G[C>T]C 1256.643 E:G[C>T]C 1241.803 A:G[T>A]C 666.606 E:G[T>A]C 668.11 A:G[T>C]C 683.32 E:G[T>C]C 665.545 A:G[T>G]C 269.208 E:G[T>G]C 260.376 A:G[C>A]G 164.149 E:G[C>A]G 161.311 A:G[C>G]G 207.346 E:G[C>G]G 209.685 A:G[C>T]G 61.232 E:G[C>T]G 60.981 A:G[T>A]G 878.318 E:G[T>A]G 860.823 A:G[T>C]G 857.751 E:G[T>C]G 817.972 A:G[T>G]G 808.938 E:G[T>G]G 770.479 A:G[C>A]T 1276.599 E:G[C>A]T 1234.543 A:G[C>G]T 1407.97 E:G[C>G]T 1231.938 A:G[C>T]T 1325.733 E:G[C>T]T 1267.715 A:G[T>A]T 1287.123 E:G[T>A]T 1245.014 A:G[T>C]T 1219.372 E:G[T>C]T 1187.013 A:G[T>G]T 755.332 E:G[T>G]T 704.797 A:T[C>A]A 1074.703 E:T[C>A]A 1072.571 A:T[C>G]A 1463.582 E:T[C>G]A 1355.09 A:T[C>T]A 682.613 E:T[C>T]A 640.4 A:T[T>A]A 1152.611 E:T[T>A]A 1121.491 A:T[T>C]A 1424.087 E:T[T>C]A 1405.315 A:T[T>G]A 873.431 E:T[T>G]A 860.556 A:T[C>A]C 1741.285 E:T[C>A]C 1727.193 A:T[C>G]C 1875.687 E:T[C>G]C 1738.499 A:T[C>T]C 1479.705 E:T[C>T]C 1395.866 A:T[T>A]C 1036.647 E:T[T>A]C 1039.068 A:T[T>C]C 1135.393 E:T[T>C]C 1108.237 A:T[T>G]C 487.098 E:T[T>G]C 478.07 A:T[C>A]G 123.227 E:T[C>A]G 121.215 A:T[C>G]G 87.791 E:T[C>G]G 84.504 A:T[C>T]G 102.642 E:T[C>T]G 98.654 A:T[T>A]G 712.14 E:T[T>A]G 704.037 A:T[T>C]G 678.556 E:T[T>C]G 633.972 A:T[T>G]G 874.316 E:T[T>G]G 847.155 A:T[C>A]T 1587.511 E:T[C>A]T 1513.972 A:T[C>G]T 2878.511 E:T[C>G]T 2540.328 A:T[C>T]T 1052.994 E:T[C>T]T 961.127 A:T[T>A]T 1879.732 E:T[T>A]T 1811.262 A:T[T>C]T 1496.748 E:T[T>C]T 1412.312 A:T[T>G]T 1341.54 E:T[T>G]T 1258.411 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Bone-Osteosarc SBS3 C>A 480.0 565.0 517.18 530.69 0.11534326048884865 0.31995439047238056 18.225 5734.0 Leading 1.177 1.026 1.147 1 480.0 517.18 470.0 559.0 [500, 493, 539, 492, 529, 523, 527, 508, 524, 553, 531, 500, 490, 539, 517, 516, 494, 522, 532, 527, 496, 509, 525, 519, 523, 542, 513, 506, 501, 504, 508, 542, 470, 509, 515, 500, 502, 523, 516, 510, 509, 496, 522, 533, 510, 520, 496, 511, 549, 520, 486, 481, 501, 515, 511, 539, 519, 534, 515, 501, 519, 509, 540, 524, 494, 501, 521, 531, 533, 501, 520, 559, 510, 512, 556, 525, 555, 527, 541, 525, 483, 502, 518, 520, 519, 531, 535, 529, 527, 530, 544, 531, 519, 491, 500, 530, 503, 508, 513, 525] 565.0 530.69 481.0 570.0 [552, 547, 509, 563, 517, 523, 518, 543, 518, 488, 536, 540, 549, 515, 532, 531, 555, 533, 517, 521, 562, 546, 522, 524, 530, 518, 542, 541, 549, 535, 549, 490, 570, 537, 529, 552, 536, 529, 534, 543, 537, 538, 539, 527, 530, 536, 558, 543, 520, 516, 564, 561, 543, 529, 526, 519, 535, 535, 531, 537, 521, 549, 512, 524, 538, 540, 526, 516, 523, 550, 523, 496, 532, 540, 481, 525, 496, 525, 504, 518, 565, 546, 533, 505, 535, 493, 514, 512, 529, 528, 498, 522, 532, 554, 544, 513, 546, 541, 542, 509] Bone-Osteosarc SBS3 C>G 773.0 745.0 759.66 770.14 0.4912537766796206 0.9185405245295156 26.474 5734.0 Lagging 1.038 0.986 1.052 773.0 759.66 698.0 806.0 [775, 779, 765, 785, 765, 765, 761, 725, 762, 772, 766, 729, 743, 708, 737, 753, 732, 752, 761, 710, 770, 803, 762, 738, 790, 748, 726, 739, 740, 762, 777, 783, 765, 782, 784, 732, 760, 753, 790, 758, 730, 778, 748, 763, 787, 730, 764, 772, 759, 734, 742, 760, 740, 783, 800, 753, 781, 730, 754, 769, 792, 781, 771, 753, 786, 763, 717, 778, 780, 698, 769, 752, 751, 806, 741, 739, 751, 758, 786, 745, 766, 749, 754, 750, 777, 802, 803, 759, 739, 779, 735, 762, 772, 739, 795, 769, 764, 754, 727, 770] 745.0 770.14 720.0 826.0 [756, 736, 786, 744, 768, 771, 772, 805, 758, 752, 759, 794, 795, 802, 788, 762, 790, 795, 784, 824, 766, 736, 771, 801, 743, 775, 797, 793, 783, 777, 728, 750, 759, 752, 761, 798, 782, 780, 742, 787, 775, 750, 783, 764, 740, 785, 783, 770, 785, 779, 798, 763, 784, 750, 720, 765, 743, 800, 766, 765, 728, 766, 775, 757, 757, 766, 793, 750, 748, 826, 766, 782, 775, 731, 788, 785, 793, 781, 759, 770, 757, 784, 783, 763, 760, 724, 760, 771, 777, 767, 809, 763, 760, 788, 741, 748, 766, 765, 783, 759] Bone-Osteosarc SBS3 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5734.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Bone-Osteosarc SBS3 T>A 1246.0 1138.0 1208.42 1189.53 0.2029816405537851 0.49966396167158905 41.577 5734.0 Lagging 1.095 1.016 1.078 1246.0 1208.42 1163.0 1281.0 [1192, 1222, 1198, 1249, 1197, 1201, 1255, 1174, 1215, 1187, 1208, 1199, 1216, 1205, 1222, 1240, 1224, 1206, 1228, 1194, 1199, 1182, 1281, 1189, 1256, 1230, 1173, 1176, 1173, 1225, 1197, 1227, 1214, 1211, 1241, 1198, 1193, 1186, 1220, 1199, 1210, 1215, 1213, 1185, 1263, 1232, 1214, 1203, 1196, 1209, 1205, 1230, 1204, 1235, 1218, 1216, 1198, 1163, 1189, 1242, 1206, 1188, 1196, 1232, 1190, 1212, 1185, 1240, 1192, 1246, 1210, 1203, 1223, 1229, 1219, 1163, 1239, 1185, 1192, 1220, 1212, 1201, 1242, 1199, 1226, 1174, 1232, 1180, 1233, 1170, 1194, 1200, 1177, 1184, 1197, 1203, 1193, 1211, 1188, 1214] 1138.0 1189.53 1126.0 1238.0 [1195, 1193, 1222, 1147, 1208, 1192, 1146, 1234, 1177, 1174, 1186, 1196, 1190, 1208, 1161, 1174, 1169, 1197, 1171, 1238, 1185, 1195, 1126, 1210, 1143, 1184, 1228, 1215, 1210, 1180, 1225, 1185, 1208, 1183, 1151, 1198, 1201, 1206, 1174, 1210, 1182, 1172, 1205, 1201, 1135, 1173, 1194, 1215, 1210, 1193, 1205, 1173, 1194, 1173, 1187, 1164, 1188, 1223, 1204, 1173, 1176, 1173, 1201, 1168, 1203, 1202, 1206, 1160, 1190, 1181, 1181, 1192, 1177, 1155, 1177, 1223, 1152, 1201, 1182, 1212, 1202, 1209, 1152, 1177, 1162, 1225, 1164, 1185, 1186, 1219, 1190, 1199, 1181, 1229, 1219, 1209, 1213, 1164, 1224, 1173] Bone-Osteosarc SBS3 T>C 176.0 157.0 167.08 166.03 0.535114040324463 0.9654358915659855 5.807 5734.0 Lagging 1.121 1.006 1.114 1 176.0 167.08 142.0 183.0 [179, 163, 160, 164, 165, 177, 178, 147, 168, 168, 171, 166, 162, 142, 168, 183, 170, 163, 161, 151, 162, 169, 179, 168, 177, 169, 167, 176, 173, 163, 170, 164, 164, 171, 166, 174, 168, 173, 176, 175, 157, 175, 155, 167, 178, 168, 181, 178, 163, 168, 173, 160, 168, 159, 170, 163, 174, 165, 172, 166, 177, 142, 170, 156, 156, 172, 168, 174, 168, 171, 167, 173, 155, 160, 152, 166, 180, 165, 169, 167, 165, 179, 172, 174, 154, 162, 168, 158, 170, 159, 172, 173, 158, 173, 165, 179, 161, 161, 164, 163] 157.0 166.03 142.0 190.0 [142, 172, 179, 175, 171, 159, 151, 179, 161, 171, 167, 162, 171, 186, 161, 150, 159, 166, 171, 174, 178, 165, 156, 166, 154, 168, 165, 165, 155, 165, 162, 171, 167, 167, 170, 159, 164, 161, 163, 167, 178, 166, 182, 166, 157, 163, 156, 155, 167, 171, 170, 165, 162, 170, 169, 176, 157, 164, 155, 174, 160, 190, 168, 184, 174, 167, 162, 159, 161, 159, 166, 162, 170, 165, 173, 165, 160, 174, 169, 169, 169, 144, 164, 162, 178, 169, 166, 178, 161, 165, 157, 158, 171, 155, 171, 155, 175, 169, 170, 171] Bone-Osteosarc SBS3 T>G 230.0 224.0 233.49 224.07 0.9471977425019652 1.0 7.918 5734.0 Lagging 1.027 1.042 0.985 230.0 233.49 204.0 267.0 [233, 235, 222, 230, 250, 251, 241, 230, 227, 215, 254, 229, 252, 240, 230, 221, 251, 239, 230, 247, 229, 226, 230, 225, 263, 240, 225, 226, 236, 228, 204, 235, 231, 212, 237, 245, 221, 222, 224, 247, 222, 243, 241, 233, 233, 238, 205, 219, 225, 230, 242, 249, 250, 228, 230, 223, 246, 242, 229, 228, 248, 239, 239, 267, 220, 234, 228, 242, 239, 231, 240, 219, 242, 226, 217, 225, 207, 239, 237, 212, 260, 246, 233, 220, 212, 255, 227, 228, 228, 259, 228, 242, 237, 245, 229, 216, 241, 222, 250, 231] 224.0 224.07 192.0 256.0 [217, 223, 238, 225, 198, 201, 213, 228, 229, 231, 212, 223, 212, 226, 228, 244, 212, 227, 224, 211, 237, 221, 243, 221, 204, 220, 241, 244, 221, 230, 256, 218, 231, 238, 222, 214, 232, 237, 225, 209, 226, 211, 216, 221, 236, 223, 256, 233, 241, 239, 208, 211, 199, 238, 230, 236, 204, 211, 229, 220, 211, 215, 214, 192, 230, 223, 224, 209, 222, 226, 227, 240, 206, 236, 234, 239, 243, 216, 215, 244, 193, 210, 230, 235, 238, 212, 231, 240, 228, 203, 225, 219, 232, 214, 232, 237, 209, 234, 213, 232] Breast-Cancer SBS3 C>A 110992.0 111604.0 110680.75 112678.16 0.03877820472647536 0.12478146116568851 21.34 1043094.0 Leading 1.006 1.018 0.988 110992.0 110680.75 110003.0 111239.0 [110780, 111164, 110452, 110599, 111239, 110914, 110922, 110265, 110367, 110689, 110801, 110537, 110234, 110739, 110739, 110749, 110736, 110676, 110284, 110421, 110421, 110742, 110724, 110842, 110982, 110578, 110985, 110755, 110994, 110842, 110659, 110805, 110741, 110593, 110806, 110555, 110142, 110608, 110667, 110557, 110904, 110734, 110771, 110003, 110389, 110767, 110445, 110674, 110701, 110745, 111132, 110483, 110862, 110823, 110827, 110380, 110680, 110648, 110474, 110540, 110564, 111051, 110492, 110413, 110724, 110593, 110647, 110692, 110807, 110692, 110472, 110746, 110600, 110880, 110916, 110913, 110134, 110500, 110600, 110979, 110938, 110762, 111180, 110823, 110830, 110830, 110409, 110810, 110323, 110594, 110414, 110246, 110978, 110270, 110860, 110956, 111030, 110769, 110780, 110571] 111604.0 112678.16 112113.0 113210.0 [112500, 112113, 112829, 112942, 112119, 112894, 112479, 113087, 112960, 112848, 112429, 112767, 112754, 112475, 112563, 112654, 112728, 112608, 113164, 112923, 112711, 112512, 112649, 112393, 112363, 112714, 112332, 112588, 112547, 112615, 113041, 112433, 112759, 112701, 112538, 112868, 112998, 112647, 112872, 112798, 112674, 112843, 112635, 113210, 112973, 112467, 113157, 112618, 112771, 112553, 112265, 112841, 112408, 112742, 112606, 112972, 113022, 112537, 112853, 112926, 112886, 112468, 112835, 112940, 112748, 112685, 112682, 112801, 112803, 112980, 112967, 112608, 112763, 112419, 112451, 112474, 113022, 112693, 112610, 112417, 112350, 112518, 112138, 112492, 112519, 112379, 112669, 112515, 112903, 112403, 112799, 113016, 112464, 113081, 112434, 112532, 112388, 112465, 112661, 112850] Breast-Cancer SBS3 C>G 95883.0 82992.0 88810.4 90078.51 5.036751475841015e-124 1.0293006949092099e-122 17.149 1043094.0 Lagging 1.155 0.986 1.172 1 95883.0 88810.4 88146.0 89468.0 [89104, 88927, 89468, 88970, 88797, 88843, 88705, 89032, 88519, 89023, 89112, 88546, 88740, 88425, 88901, 89025, 88634, 88910, 88718, 88732, 88146, 88828, 88575, 88756, 89052, 88666, 88825, 88593, 89114, 88982, 88960, 88977, 88862, 89269, 89081, 88676, 88435, 88552, 88536, 88682, 88720, 89151, 88519, 88907, 88828, 88598, 88681, 89302, 88931, 88876, 88643, 89375, 88851, 88713, 88716, 88897, 88912, 88953, 89067, 88526, 88740, 89164, 88879, 88776, 88634, 88464, 88732, 88980, 88847, 88787, 89380, 88980, 88167, 88882, 88294, 89145, 88727, 88697, 88878, 88716, 88771, 88570, 88721, 88797, 88648, 89107, 89242, 88901, 88991, 88799, 88804, 88472, 88253, 88367, 88567, 88821, 89159, 88882, 88694, 88741] 82992.0 90078.51 89402.0 90740.0 [89813, 90161, 89437, 90020, 89924, 90131, 90369, 90071, 90587, 90019, 89916, 90119, 90108, 90158, 90195, 90015, 90131, 90031, 90418, 90066, 90689, 89838, 90301, 90174, 89878, 90122, 89958, 90173, 89888, 90058, 90009, 89818, 89826, 89857, 90059, 90147, 90350, 90153, 90373, 90311, 90226, 89841, 90307, 90139, 90350, 90138, 90120, 89759, 89995, 89890, 90267, 89402, 90130, 90075, 89933, 89788, 90015, 89819, 89927, 90282, 89993, 89585, 90012, 90254, 90340, 90201, 90311, 90047, 90109, 90140, 89629, 89927, 90740, 89820, 90457, 89559, 90070, 90077, 89889, 90024, 90231, 90472, 90082, 90111, 90243, 89716, 89820, 90091, 89615, 90203, 90089, 90232, 90570, 90226, 90391, 90286, 89800, 90011, 90350, 90054] Breast-Cancer SBS3 C>T 78751.0 71830.0 74674.22 76002.42 4.369602953587742e-51 5.511259260992754e-50 14.436 1043094.0 Lagging 1.096 0.983 1.116 1 78751.0 74674.22 74162.0 75209.0 [74529, 74610, 74359, 74570, 75004, 74756, 74898, 74968, 74365, 74650, 74951, 74396, 74863, 74578, 74380, 74876, 74853, 74629, 74403, 74607, 74572, 74606, 74685, 74818, 74613, 74438, 74853, 74640, 74705, 74733, 74645, 74744, 74639, 74961, 74868, 74953, 74580, 74593, 74691, 74710, 74910, 75209, 74943, 74580, 74850, 74605, 74378, 74492, 74730, 74717, 74601, 74630, 74654, 74637, 74611, 74596, 74645, 74526, 74587, 74645, 74784, 74672, 74822, 74954, 74785, 74434, 74645, 74691, 74753, 74813, 74469, 74797, 74338, 74815, 74355, 74757, 74773, 74403, 74874, 74647, 74657, 74655, 74703, 74614, 74804, 74712, 74827, 74824, 74638, 74692, 74469, 74814, 74759, 74948, 74485, 74751, 74648, 74476, 74162, 74365] 71830.0 76002.42 75448.0 76480.0 [76090, 76119, 76147, 76089, 75774, 75980, 75730, 75828, 76124, 76071, 75745, 76251, 75910, 75959, 76215, 75853, 75937, 76279, 76269, 76027, 76013, 76271, 76018, 75974, 76202, 76044, 75788, 75974, 75850, 75816, 76050, 75980, 76060, 75731, 75984, 75876, 76173, 76096, 76017, 76007, 75851, 75448, 75801, 76164, 75920, 76050, 76176, 76215, 75836, 75888, 75890, 75887, 76138, 76021, 76072, 75949, 75964, 76184, 76067, 76093, 75769, 76114, 75999, 75744, 75967, 76277, 75953, 75942, 75957, 75805, 76201, 75821, 76411, 75749, 76480, 75889, 75836, 76181, 75803, 75921, 76086, 76084, 75999, 75855, 75780, 75938, 75909, 75696, 75953, 76063, 76290, 75832, 75820, 75842, 76163, 76044, 76186, 76108, 76478, 76362] Breast-Cancer SBS3 T>A 95187.0 95039.0 96557.71 94564.66 0.0029163573151567857 0.011423831548903583 18.237 1043094.0 Lagging 1.002 1.021 0.981 95187.0 96557.71 95934.0 97251.0 [96610, 96358, 96663, 96399, 96170, 96551, 96558, 96500, 97251, 96978, 96367, 96513, 96662, 96399, 96407, 96497, 96612, 96294, 96561, 96494, 96463, 97023, 96180, 96465, 96643, 96500, 96648, 96419, 96589, 96499, 96693, 96417, 96156, 96650, 96550, 96743, 96733, 96284, 96924, 96297, 96561, 96336, 96259, 96494, 96576, 96497, 96611, 96414, 96715, 96928, 96708, 97045, 96616, 96590, 96093, 96698, 96845, 96757, 96699, 96660, 96490, 96339, 96151, 96318, 96380, 96928, 96316, 96678, 96473, 96569, 96387, 96650, 96442, 96430, 96338, 96985, 96674, 96918, 96728, 96660, 96618, 96495, 96893, 96392, 96546, 96469, 96704, 96544, 96699, 96544, 96884, 95934, 96419, 96626, 96724, 96514, 96785, 96340, 96373, 96592] 95039.0 94564.66 94133.0 95124.0 [94433, 94805, 94464, 94619, 95038, 94371, 94491, 94544, 94133, 94235, 94650, 94623, 94559, 94860, 94742, 94661, 94446, 94762, 94503, 94624, 94765, 94176, 94836, 94706, 94411, 94411, 94442, 94812, 94456, 94488, 94536, 94783, 94766, 94347, 94585, 94431, 94569, 95027, 94206, 94860, 94548, 94667, 94705, 94436, 94215, 94756, 94557, 94430, 94417, 94169, 94349, 94345, 94570, 94566, 94909, 94674, 94174, 94422, 94420, 94341, 94610, 94739, 95009, 94519, 94591, 94327, 94877, 94536, 94756, 94564, 94432, 94259, 94595, 94778, 94680, 94189, 94377, 94283, 94421, 94678, 94891, 94729, 94487, 94703, 94715, 94972, 94251, 94547, 94223, 94653, 94460, 95124, 94827, 94240, 94434, 94684, 94384, 94532, 94776, 94768] Breast-Cancer SBS3 T>C 92986.0 89413.0 92186.98 90480.73 0.001966169127694982 0.007848702688831153 17.486 1043094.0 Lagging 1.04 1.019 1.021 92986.0 92186.98 91714.0 92687.0 [91950, 92022, 92077, 91851, 91900, 91990, 92125, 92086, 91898, 92048, 92359, 92179, 92524, 92273, 92434, 92259, 91925, 92020, 92367, 91901, 91999, 92408, 92216, 92441, 91913, 92318, 92514, 92096, 92369, 92226, 92056, 92154, 92227, 92316, 91919, 92048, 91910, 92058, 91849, 92226, 91714, 92290, 92046, 92200, 92101, 92386, 92226, 92660, 92500, 92049, 92394, 92125, 92401, 92227, 92219, 91727, 92438, 92312, 92105, 92178, 92346, 92183, 92008, 92097, 92071, 92172, 92283, 92288, 92156, 91926, 92386, 92291, 92041, 91730, 92355, 92469, 92221, 92127, 92266, 92102, 92202, 92687, 92205, 91951, 92048, 92109, 92072, 92605, 92578, 92245, 92241, 92373, 92032, 92347, 92358, 92085, 92484, 92075, 92596, 92138] 89413.0 90480.73 89941.0 90949.0 [90590, 90532, 90757, 90857, 90949, 90868, 90481, 90686, 90703, 90578, 90384, 90407, 90120, 90533, 90235, 90544, 90657, 90354, 90580, 90751, 90598, 90470, 90403, 90211, 90792, 90323, 90184, 90578, 90395, 90352, 90674, 90619, 90288, 90391, 90801, 90752, 90637, 90598, 90688, 90406, 90817, 90464, 90635, 90380, 90648, 90423, 90398, 90239, 90152, 90512, 90093, 90597, 90342, 90429, 90420, 90765, 90285, 90316, 90701, 90393, 89941, 90458, 90578, 90491, 90471, 90528, 90327, 90460, 90548, 90794, 90424, 90473, 90571, 90932, 90196, 90262, 90190, 90457, 90474, 90664, 90386, 90120, 90574, 90829, 90509, 90421, 90748, 90162, 89949, 90307, 90344, 90486, 90482, 90487, 90458, 90501, 90283, 90564, 90143, 90346] Breast-Cancer SBS3 T>G 60651.0 57766.0 59961.64 58410.52 0.00618526188530936 0.02319165380420739 11.352 1043094.0 Lagging 1.05 1.027 1.023 60651.0 59961.64 59466.0 60352.0 [59691, 59811, 59909, 60018, 60027, 59758, 59864, 59631, 60148, 59492, 60076, 60296, 60015, 60004, 59674, 59847, 60070, 60160, 60015, 59902, 60164, 60094, 60233, 60129, 59924, 59777, 60208, 59646, 59864, 60000, 59969, 59981, 60052, 59881, 59900, 59571, 60089, 59797, 60220, 59964, 59481, 59528, 59671, 60026, 60013, 59466, 60226, 59956, 59751, 59819, 59610, 59948, 60344, 60132, 60191, 59889, 60251, 59811, 60081, 60254, 60024, 59919, 59869, 59921, 59915, 59959, 59982, 60041, 59892, 59745, 60239, 59926, 60149, 59884, 60209, 59708, 59953, 59893, 59806, 59757, 60040, 60036, 60041, 60096, 60151, 60177, 59828, 59953, 59926, 60329, 59990, 60352, 60056, 59894, 59857, 60001, 59922, 60065, 60120, 60220] 57766.0 58410.52 57993.0 58923.0 [58543, 58674, 58517, 58286, 58223, 58649, 58475, 58766, 58233, 58673, 58505, 58101, 58403, 58364, 58742, 58393, 58400, 58211, 58514, 58483, 58286, 58202, 58238, 58324, 58495, 58463, 58216, 58564, 58515, 58358, 58322, 58377, 58356, 58470, 58405, 58583, 58463, 58411, 58269, 58331, 58722, 58923, 58708, 58432, 58424, 58798, 58243, 58224, 58665, 58449, 58668, 58415, 57993, 58098, 58270, 58451, 58194, 58536, 58236, 58215, 58317, 58393, 58331, 58475, 58345, 58369, 58459, 58376, 58522, 58711, 58204, 58468, 58389, 58598, 58110, 58637, 58427, 58561, 58573, 58553, 58302, 58239, 58495, 58297, 58150, 58095, 58455, 58386, 58422, 58122, 58561, 58040, 58273, 58526, 58597, 58399, 58449, 58374, 58246, 58339] CNS-Medullo SBS3 C>A 644.0 681.0 658.06 666.61 0.5864531933782302 1.0 23.096 5737.0 Leading 1.057 1.013 1.044 644.0 658.06 611.0 727.0 [650, 675, 651, 638, 623, 646, 647, 669, 657, 661, 675, 655, 675, 664, 659, 648, 637, 662, 646, 671, 645, 692, 641, 679, 653, 675, 686, 687, 679, 669, 687, 629, 677, 635, 641, 645, 664, 669, 611, 651, 679, 649, 663, 648, 645, 634, 664, 641, 672, 623, 664, 621, 640, 612, 659, 688, 664, 669, 657, 668, 634, 666, 678, 651, 673, 665, 657, 659, 677, 642, 641, 639, 659, 668, 646, 665, 690, 683, 699, 650, 657, 651, 622, 664, 664, 618, 624, 630, 685, 667, 656, 678, 727, 662, 672, 691, 665, 627, 644, 676] 681.0 666.61 616.0 724.0 [680, 668, 678, 681, 696, 677, 695, 642, 656, 671, 638, 676, 652, 669, 680, 674, 686, 668, 682, 653, 677, 654, 680, 644, 662, 650, 644, 646, 634, 662, 638, 659, 650, 680, 675, 671, 661, 647, 707, 671, 657, 673, 666, 681, 687, 689, 662, 668, 634, 708, 664, 680, 698, 711, 675, 639, 651, 663, 650, 662, 664, 649, 649, 682, 653, 649, 650, 678, 656, 676, 707, 681, 683, 673, 688, 642, 643, 661, 627, 667, 661, 663, 716, 668, 641, 711, 680, 691, 637, 659, 661, 645, 616, 673, 664, 626, 674, 724, 671, 650] CNS-Medullo SBS3 C>G 482.0 387.0 436.19 440.61 0.01880077232817058 0.06469778565184402 15.147 5737.0 Lagging 1.245 0.99 1.258 1 1 482.0 436.19 404.0 470.0 [428, 431, 439, 438, 464, 452, 438, 420, 457, 416, 432, 445, 448, 430, 461, 438, 422, 428, 422, 435, 435, 445, 435, 407, 434, 434, 428, 419, 416, 425, 464, 440, 445, 428, 430, 417, 445, 456, 455, 415, 446, 470, 431, 433, 425, 438, 437, 431, 422, 412, 406, 420, 465, 446, 414, 435, 444, 446, 454, 439, 436, 404, 441, 432, 465, 437, 447, 452, 443, 445, 408, 436, 447, 423, 456, 420, 454, 448, 457, 438, 423, 445, 444, 434, 443, 407, 431, 417, 425, 462, 444, 433, 409, 443, 431, 417, 461, 452, 432, 446] 387.0 440.61 409.0 478.0 [435, 455, 434, 441, 421, 433, 434, 457, 416, 459, 457, 438, 419, 454, 414, 435, 464, 455, 456, 430, 445, 432, 435, 478, 453, 445, 442, 463, 457, 436, 419, 439, 431, 447, 440, 472, 427, 418, 422, 447, 426, 416, 438, 440, 455, 433, 438, 450, 459, 454, 467, 451, 410, 435, 459, 445, 430, 419, 417, 442, 440, 473, 435, 447, 431, 426, 444, 440, 439, 426, 453, 451, 442, 447, 424, 443, 431, 439, 413, 440, 459, 433, 444, 453, 440, 468, 443, 450, 441, 409, 435, 445, 464, 421, 451, 454, 420, 434, 440, 434] CNS-Medullo SBS3 C>T 326.0 324.0 324.66 327.77 0.9117370790830122 1.0 11.33 5737.0 Lagging 1.006 0.991 1.016 326.0 324.66 289.0 363.0 [326, 321, 305, 331, 300, 333, 314, 337, 332, 323, 327, 318, 335, 318, 328, 336, 322, 318, 332, 339, 302, 336, 332, 327, 344, 328, 328, 328, 344, 300, 317, 322, 333, 333, 316, 330, 330, 289, 329, 315, 324, 321, 340, 328, 320, 363, 329, 314, 292, 344, 328, 331, 336, 341, 331, 360, 326, 314, 344, 342, 320, 331, 324, 331, 316, 332, 326, 329, 339, 319, 307, 292, 303, 327, 337, 317, 305, 326, 326, 320, 312, 326, 328, 313, 339, 317, 296, 342, 320, 332, 325, 323, 315, 316, 311, 333, 335, 307, 301, 342] 324.0 327.77 298.0 365.0 [331, 325, 345, 312, 354, 323, 336, 330, 327, 336, 325, 327, 317, 336, 329, 318, 324, 330, 316, 313, 340, 316, 324, 324, 310, 326, 333, 316, 315, 351, 329, 342, 319, 313, 331, 332, 321, 365, 324, 332, 339, 326, 308, 316, 330, 300, 327, 324, 351, 310, 325, 324, 313, 325, 321, 298, 340, 342, 329, 310, 318, 323, 331, 325, 334, 323, 322, 324, 311, 328, 337, 351, 349, 331, 321, 351, 337, 333, 336, 335, 340, 326, 334, 327, 315, 323, 349, 312, 335, 328, 321, 319, 330, 339, 339, 326, 328, 339, 349, 303] CNS-Medullo SBS3 T>A 599.0 589.0 587.31 576.27 1.0 1.0 20.708 5737.0 Lagging 1.017 1.019 0.998 599.0 587.31 540.0 627.0 [607, 540, 557, 552, 602, 612, 581, 596, 595, 558, 598, 611, 589, 627, 615, 564, 598, 567, 607, 593, 578, 564, 574, 582, 546, 585, 567, 582, 581, 606, 581, 586, 550, 608, 608, 613, 556, 588, 561, 578, 602, 570, 618, 594, 618, 556, 602, 594, 613, 600, 610, 583, 594, 602, 589, 569, 582, 608, 581, 542, 602, 586, 573, 577, 567, 586, 573, 588, 579, 575, 599, 587, 608, 569, 561, 570, 578, 603, 561, 585, 587, 600, 624, 595, 592, 583, 589, 604, 581, 593, 592, 595, 612, 597, 583, 581, 593, 614, 587, 612] 589.0 576.27 540.0 623.0 [552, 601, 599, 588, 566, 552, 580, 564, 571, 605, 566, 562, 574, 545, 554, 607, 572, 588, 552, 570, 571, 593, 609, 562, 599, 575, 595, 577, 586, 565, 584, 568, 600, 557, 568, 540, 601, 573, 601, 574, 558, 582, 562, 568, 549, 579, 577, 571, 566, 567, 561, 583, 588, 583, 583, 587, 573, 567, 585, 595, 557, 585, 574, 584, 594, 573, 598, 588, 582, 584, 546, 581, 550, 595, 601, 587, 579, 577, 623, 589, 593, 551, 557, 576, 572, 581, 577, 565, 590, 582, 574, 570, 546, 568, 585, 593, 562, 560, 585, 543] CNS-Medullo SBS3 T>C 612.0 622.0 606.94 595.75 0.6852950146876593 1.0 21.509 5737.0 Leading 1.016 0.982 1.035 612.0 606.94 551.0 661.0 [600, 608, 586, 607, 639, 603, 611, 620, 606, 601, 606, 604, 581, 577, 645, 609, 574, 604, 629, 629, 626, 619, 607, 587, 590, 605, 601, 618, 585, 604, 612, 628, 599, 616, 601, 608, 588, 615, 613, 598, 601, 661, 551, 648, 615, 613, 619, 604, 608, 610, 622, 642, 603, 607, 626, 600, 609, 619, 591, 592, 612, 616, 606, 585, 618, 600, 559, 617, 629, 604, 608, 584, 604, 597, 597, 619, 559, 620, 625, 598, 622, 625, 618, 605, 586, 581, 597, 616, 583, 603, 617, 628, 618, 612, 630, 611, 568, 582, 632, 603] 622.0 595.75 551.0 646.0 [609, 591, 624, 593, 564, 607, 596, 582, 589, 611, 605, 603, 626, 621, 556, 588, 604, 589, 574, 574, 559, 576, 617, 593, 611, 585, 599, 594, 612, 590, 594, 564, 585, 589, 614, 608, 617, 588, 586, 613, 615, 551, 646, 563, 602, 608, 583, 599, 599, 607, 594, 579, 596, 595, 566, 591, 608, 592, 606, 589, 585, 603, 587, 615, 592, 601, 645, 596, 579, 592, 603, 620, 596, 617, 591, 588, 633, 565, 585, 606, 573, 570, 591, 606, 601, 611, 621, 587, 616, 595, 585, 577, 590, 584, 585, 589, 645, 603, 562, 596] CNS-Medullo SBS3 T>G 254.0 217.0 237.0 232.6 0.32735070986836895 0.7106856802116711 8.21 5737.0 Lagging 1.171 1.019 1.149 1 254.0 237.0 210.0 262.0 [223, 241, 233, 219, 240, 223, 238, 238, 257, 255, 222, 238, 241, 230, 231, 261, 227, 221, 252, 247, 232, 236, 210, 241, 233, 221, 241, 242, 232, 251, 224, 223, 250, 246, 228, 248, 243, 238, 247, 252, 237, 244, 254, 242, 223, 236, 225, 214, 234, 232, 254, 231, 232, 224, 245, 248, 253, 240, 248, 240, 234, 242, 215, 249, 242, 236, 231, 222, 246, 235, 223, 240, 254, 243, 238, 245, 232, 235, 250, 250, 229, 230, 234, 219, 231, 252, 247, 218, 239, 227, 252, 235, 227, 231, 228, 246, 236, 219, 245, 262] 217.0 232.6 209.0 263.0 [246, 234, 234, 256, 228, 248, 237, 234, 214, 215, 239, 235, 232, 240, 239, 216, 240, 249, 219, 235, 249, 237, 252, 232, 238, 238, 233, 225, 234, 218, 250, 256, 234, 235, 235, 224, 226, 230, 223, 217, 221, 237, 211, 236, 240, 239, 239, 245, 233, 241, 217, 235, 245, 247, 225, 215, 216, 236, 224, 219, 238, 216, 251, 209, 221, 228, 235, 255, 239, 238, 245, 227, 212, 232, 237, 229, 236, 232, 217, 218, 234, 234, 229, 255, 229, 217, 225, 263, 222, 231, 219, 219, 242, 240, 243, 224, 233, 241, 227, 221] ESCC SBS3 C>A 37112.0 37472.0 37293.39 38149.12 0.20768380154603752 0.5079062197082385 19.677 379038.0 Leading 1.01 1.023 0.987 37112.0 37293.39 37037.0 37688.0 [37569, 37359, 37355, 37386, 37342, 37510, 37144, 37336, 37348, 37141, 37152, 37469, 37224, 37493, 37499, 37422, 37180, 37641, 37527, 37319, 37075, 37297, 37259, 37280, 37315, 37595, 37451, 37270, 37316, 37506, 37314, 37294, 37079, 37239, 37135, 37688, 37117, 37353, 37203, 37113, 37177, 37101, 37166, 37255, 37360, 37294, 37432, 37380, 37130, 37145, 37225, 37337, 37211, 37283, 37366, 37265, 37315, 37315, 37148, 37245, 37215, 37350, 37315, 37362, 37298, 37233, 37328, 37114, 37125, 37211, 37269, 37481, 37312, 37221, 37213, 37238, 37195, 37139, 37449, 37148, 37401, 37350, 37270, 37249, 37404, 37286, 37037, 37204, 37368, 37262, 37270, 37104, 37231, 37253, 37411, 37367, 37096, 37353, 37270, 37472] 37472.0 38149.12 37698.0 38441.0 [37756, 38189, 38114, 38049, 38070, 37889, 38359, 38109, 38018, 38281, 38231, 37948, 38269, 37947, 37985, 38117, 38232, 37850, 38060, 38132, 38256, 38197, 38271, 38211, 38209, 37881, 37901, 38205, 38094, 38120, 38040, 38346, 38143, 38128, 38257, 37698, 38232, 38076, 38355, 38336, 38128, 38441, 38093, 38130, 38153, 38138, 37918, 38190, 38337, 38222, 38361, 38111, 38250, 38149, 38095, 38243, 38245, 38183, 38307, 38161, 38328, 38156, 38090, 38139, 38086, 38247, 38142, 38216, 38329, 38161, 38250, 37941, 38094, 38168, 38256, 38059, 38230, 38205, 38002, 38225, 38105, 38142, 38304, 38311, 37930, 38135, 38332, 38256, 38005, 37967, 38114, 38374, 38366, 38232, 37956, 38112, 38392, 38031, 38084, 38024] ESCC SBS3 C>G 47851.0 43447.0 45457.71 46335.03 3.983563842064456e-35 4.239007060185538e-34 24.087 379038.0 Lagging 1.101 0.981 1.123 1 47851.0 45457.71 45106.0 45929.0 [45225, 45552, 45394, 45282, 45175, 45186, 45449, 45324, 45627, 45568, 45470, 45638, 45332, 45584, 45381, 45418, 45292, 45336, 45399, 45621, 45362, 45776, 45576, 45617, 45618, 45395, 45300, 45582, 45444, 45106, 45508, 45632, 45233, 45559, 45643, 45415, 45476, 45428, 45573, 45623, 45387, 45918, 45354, 45348, 45353, 45344, 45553, 45484, 45227, 45250, 45385, 45372, 45489, 45329, 45608, 45420, 45445, 45360, 45407, 45320, 45625, 45358, 45498, 45620, 45590, 45106, 45444, 45454, 45475, 45377, 45279, 45572, 45424, 45646, 45631, 45459, 45304, 45540, 45656, 45642, 45429, 45268, 45632, 45318, 45286, 45454, 45543, 45348, 45373, 45397, 45495, 45621, 45586, 45929, 45548, 45474, 45378, 45656, 45295, 45569] 43447.0 46335.03 45899.0 46708.0 [46583, 46186, 46464, 46498, 46471, 46577, 46271, 46488, 46013, 46198, 46343, 46151, 46457, 46356, 46356, 46428, 46482, 46431, 46508, 46271, 46490, 46041, 46076, 46117, 46241, 46331, 46429, 46107, 46379, 46644, 46304, 46206, 46488, 46263, 46340, 46305, 46296, 46384, 46226, 46118, 46349, 45990, 46298, 46444, 46399, 46412, 46304, 46359, 46532, 46481, 46317, 46528, 46328, 46278, 46268, 46445, 46204, 46421, 46368, 46471, 46237, 46385, 46343, 46063, 46294, 46574, 46399, 46283, 46403, 46433, 46668, 46231, 46293, 46080, 46122, 46581, 46411, 46278, 46167, 46099, 46330, 46415, 46084, 46530, 46708, 46197, 46385, 46443, 46420, 46458, 46338, 46277, 46187, 45899, 46249, 46419, 46335, 46199, 46498, 46275] ESCC SBS3 C>T 12526.0 11729.0 12056.16 12234.45 9.818003596645219e-06 4.868506303013936e-05 6.399 379038.0 Lagging 1.068 0.985 1.084 12526.0 12056.16 11836.0 12225.0 [12027, 12004, 12128, 12052, 11996, 12047, 12117, 12016, 12068, 11998, 12038, 12056, 12004, 12087, 12123, 12134, 11945, 11913, 12121, 11953, 11997, 12106, 12188, 12082, 11988, 11996, 11950, 12159, 12047, 12204, 11956, 12051, 12055, 12114, 12052, 12163, 12136, 12176, 12160, 11994, 12120, 12065, 12064, 12018, 12098, 12049, 12225, 11913, 12071, 11955, 12052, 11836, 12120, 12037, 12129, 12107, 12000, 12036, 12081, 12107, 12089, 12121, 12075, 12007, 12167, 12083, 12106, 12011, 12193, 12026, 11980, 12045, 12168, 12104, 12100, 12043, 12109, 12139, 12098, 11982, 12059, 12090, 11935, 12014, 12002, 11931, 11979, 12070, 11923, 12112, 11930, 12200, 12057, 12107, 11997, 12072, 12097, 11893, 12023, 11995] 11729.0 12234.45 12043.0 12437.0 [12270, 12275, 12174, 12179, 12355, 12216, 12243, 12292, 12155, 12316, 12229, 12239, 12240, 12234, 12184, 12151, 12298, 12399, 12190, 12283, 12196, 12187, 12106, 12250, 12289, 12246, 12261, 12200, 12207, 12082, 12286, 12262, 12257, 12150, 12195, 12149, 12141, 12107, 12214, 12268, 12137, 12214, 12192, 12299, 12170, 12277, 12139, 12396, 12195, 12376, 12272, 12437, 12172, 12295, 12189, 12216, 12259, 12319, 12136, 12183, 12219, 12195, 12292, 12245, 12190, 12157, 12233, 12264, 12043, 12262, 12360, 12240, 12156, 12195, 12199, 12259, 12140, 12162, 12191, 12369, 12198, 12269, 12383, 12305, 12248, 12273, 12337, 12213, 12330, 12177, 12387, 12175, 12323, 12219, 12233, 12160, 12192, 12382, 12163, 12259] ESCC SBS3 T>A 48167.0 49370.0 49982.99 48809.26 8.208709075208527e-08 4.6207536706886e-07 25.733 379038.0 Leading 1.025 0.977 1.05 48167.0 49982.99 49650.0 50276.0 [50100, 50035, 49902, 50101, 50154, 50255, 50112, 49767, 50270, 49959, 49943, 49926, 49751, 50258, 50053, 49899, 49741, 50132, 49985, 50007, 49730, 49959, 49909, 49678, 50127, 50095, 49821, 50059, 50128, 49926, 49803, 49968, 50051, 50010, 49689, 50000, 49775, 49919, 50276, 50085, 49792, 50241, 49898, 49956, 49978, 49650, 49889, 49964, 49784, 50160, 50269, 49832, 49968, 50003, 49861, 49871, 50065, 50004, 50064, 50080, 50003, 50103, 49909, 50155, 49975, 50056, 49801, 50049, 50048, 50028, 49925, 50104, 49841, 49922, 49840, 49698, 49846, 50161, 50042, 49707, 49824, 49964, 50015, 49919, 50088, 49752, 50053, 50222, 50180, 50153, 50211, 49785, 50180, 49926, 50120, 50231, 49995, 49852, 49721, 50208] 49370.0 48809.26 48439.0 49165.0 [48835, 48680, 48881, 48713, 48594, 48628, 48754, 48990, 48693, 48814, 48919, 48986, 48859, 48439, 48841, 48925, 49022, 48761, 48808, 48875, 49036, 48714, 48891, 49069, 48594, 48778, 48940, 48734, 48656, 48888, 48843, 48892, 48684, 48806, 48957, 48919, 48906, 48837, 48570, 48627, 48868, 48576, 48891, 48777, 48894, 49059, 48967, 48755, 49155, 48607, 48877, 49095, 48916, 48789, 48917, 48915, 48887, 48818, 48866, 48713, 48821, 48726, 48949, 48517, 48899, 48784, 48756, 48735, 48893, 48835, 48807, 48628, 48874, 48919, 48903, 49165, 48920, 48528, 48648, 48998, 48876, 48774, 48598, 48917, 48690, 48983, 48593, 48663, 48564, 48621, 48557, 49071, 48637, 48787, 48601, 48533, 48801, 48955, 49136, 48564] ESCC SBS3 T>C 21064.0 20867.0 21285.06 20852.12 0.41962991451307496 0.8390370955258777 11.062 379038.0 Lagging 1.009 1.021 0.989 21064.0 21285.06 21008.0 21547.0 [21226, 21425, 21393, 21282, 21315, 21343, 21545, 21197, 21451, 21466, 21258, 21302, 21149, 21120, 21164, 21397, 21260, 21170, 21176, 21363, 21158, 21293, 21230, 21108, 21298, 21162, 21201, 21388, 21325, 21156, 21321, 21203, 21264, 21243, 21390, 21368, 21194, 21286, 21302, 21021, 21271, 21335, 21371, 21406, 21177, 21356, 21232, 21317, 21134, 21375, 21359, 21308, 21374, 21251, 21253, 21164, 21437, 21121, 21263, 21143, 21463, 21364, 21269, 21193, 21349, 21297, 21169, 21547, 21430, 21227, 21346, 21141, 21359, 21389, 21225, 21311, 21518, 21190, 21362, 21275, 21271, 21269, 21310, 21309, 21443, 21406, 21216, 21337, 21202, 21226, 21375, 21407, 21008, 21334, 21094, 21199, 21211, 21423, 21358, 21124] 20867.0 20852.12 20619.0 21071.0 [20841, 20781, 20738, 20805, 20803, 20784, 20638, 20835, 20723, 20622, 20825, 20849, 20970, 21000, 21040, 20778, 20984, 20855, 20836, 20801, 20933, 20853, 20920, 21071, 20825, 20936, 20890, 20765, 20891, 20953, 20775, 20881, 20897, 20837, 20778, 20804, 20804, 20842, 20856, 21035, 20814, 20976, 20791, 20840, 20930, 20752, 21016, 20823, 21003, 20754, 20849, 20964, 20746, 20821, 20908, 20955, 20781, 20962, 20968, 20963, 20773, 20729, 20709, 20986, 20796, 20836, 20945, 20619, 20669, 20873, 20923, 20937, 20852, 20697, 20947, 20840, 20661, 20967, 20770, 20814, 20867, 20815, 20766, 20810, 20754, 20726, 20948, 20836, 20853, 20928, 20871, 20687, 21040, 20875, 21050, 20971, 20898, 20764, 20784, 20956] ESCC SBS3 T>G 25159.0 24274.0 25236.28 24650.75 0.3346760842446645 0.7206887248568891 13.042 379038.0 Lagging 1.036 1.024 1.012 25159.0 25236.28 24942.0 25483.0 [25007, 25364, 25317, 25379, 25205, 25078, 25261, 25299, 25009, 25106, 25197, 25384, 25413, 25104, 25195, 25483, 25329, 25247, 25235, 25206, 25166, 25324, 25268, 25267, 25220, 25246, 25275, 25159, 25305, 25187, 25061, 25195, 25394, 25293, 25213, 25339, 25219, 25196, 25306, 25053, 25321, 25083, 25337, 25247, 25225, 25159, 25088, 25185, 25305, 25196, 25333, 25135, 25360, 25100, 25260, 25368, 25055, 25133, 25268, 25368, 25269, 25016, 25127, 24956, 25081, 25244, 25320, 25200, 25218, 25197, 25210, 25115, 25331, 25120, 25284, 24942, 25230, 25445, 25313, 25294, 25304, 25429, 25128, 25314, 25391, 25316, 25150, 25390, 25262, 25296, 25126, 25381, 25264, 25307, 25327, 25354, 25229, 25336, 25263, 25119] 24274.0 24650.75 24364.0 24914.0 [24761, 24555, 24704, 24526, 24634, 24861, 24627, 24646, 24782, 24728, 24773, 24496, 24466, 24740, 24689, 24364, 24572, 24659, 24651, 24588, 24650, 24635, 24631, 24586, 24668, 24666, 24565, 24773, 24528, 24662, 24828, 24682, 24587, 24658, 24630, 24544, 24821, 24759, 24559, 24741, 24658, 24811, 24510, 24668, 24691, 24661, 24781, 24804, 24655, 24559, 24515, 24750, 24503, 24726, 24654, 24581, 24744, 24697, 24531, 24578, 24641, 24860, 24749, 24914, 24758, 24659, 24701, 24665, 24755, 24682, 24712, 24788, 24605, 24733, 24627, 24905, 24592, 24415, 24562, 24638, 24615, 24554, 24727, 24560, 24497, 24615, 24825, 24641, 24636, 24613, 24725, 24414, 24631, 24560, 24572, 24460, 24635, 24605, 24487, 24670] Eso-AdenoCA SBS3 C>A 5505.0 5684.0 5582.4 5722.53 0.7896797999357525 1.0 42.781 26154.0 Leading 1.033 1.025 1.007 5505.0 5582.4 5448.0 5701.0 [5605, 5576, 5545, 5676, 5664, 5469, 5585, 5487, 5582, 5564, 5567, 5604, 5555, 5564, 5522, 5598, 5562, 5555, 5611, 5448, 5598, 5576, 5480, 5623, 5671, 5584, 5637, 5617, 5492, 5618, 5537, 5652, 5601, 5597, 5601, 5604, 5613, 5574, 5536, 5535, 5564, 5539, 5670, 5549, 5555, 5562, 5592, 5546, 5580, 5642, 5578, 5640, 5562, 5623, 5633, 5575, 5552, 5621, 5649, 5634, 5591, 5571, 5556, 5613, 5701, 5646, 5666, 5697, 5599, 5513, 5666, 5469, 5473, 5520, 5500, 5630, 5491, 5531, 5602, 5557, 5647, 5675, 5578, 5521, 5517, 5635, 5584, 5569, 5556, 5518, 5569, 5601, 5553, 5565, 5602, 5588, 5591, 5655, 5645, 5528] 5684.0 5722.53 5574.0 5869.0 [5715, 5676, 5722, 5640, 5664, 5791, 5746, 5829, 5705, 5693, 5782, 5720, 5789, 5711, 5727, 5715, 5773, 5716, 5717, 5854, 5731, 5711, 5814, 5643, 5610, 5692, 5751, 5721, 5844, 5683, 5739, 5700, 5650, 5719, 5707, 5721, 5710, 5709, 5770, 5768, 5718, 5739, 5673, 5736, 5795, 5727, 5691, 5733, 5701, 5676, 5685, 5721, 5747, 5655, 5642, 5731, 5740, 5683, 5621, 5647, 5715, 5719, 5745, 5724, 5634, 5686, 5636, 5574, 5712, 5807, 5639, 5845, 5754, 5811, 5844, 5662, 5869, 5792, 5711, 5741, 5715, 5619, 5761, 5789, 5773, 5697, 5676, 5720, 5730, 5792, 5703, 5673, 5715, 5748, 5735, 5731, 5790, 5705, 5697, 5725] Eso-AdenoCA SBS3 C>G 3992.0 3658.0 3814.46 3883.6 0.001171784344598452 0.0047979474196764875 29.25 26154.0 Lagging 1.091 0.982 1.111 1 3992.0 3814.46 3703.0 3949.0 [3854, 3859, 3728, 3817, 3843, 3789, 3802, 3813, 3783, 3829, 3818, 3910, 3865, 3775, 3743, 3854, 3852, 3795, 3842, 3816, 3727, 3703, 3862, 3832, 3949, 3787, 3825, 3856, 3869, 3841, 3825, 3818, 3796, 3906, 3790, 3858, 3862, 3838, 3800, 3785, 3838, 3793, 3768, 3828, 3821, 3785, 3871, 3744, 3727, 3770, 3817, 3790, 3729, 3767, 3730, 3853, 3749, 3866, 3809, 3875, 3797, 3782, 3762, 3831, 3880, 3765, 3857, 3851, 3855, 3787, 3794, 3879, 3777, 3842, 3787, 3871, 3832, 3809, 3805, 3852, 3812, 3895, 3790, 3786, 3792, 3832, 3820, 3790, 3745, 3767, 3868, 3756, 3811, 3794, 3790, 3817, 3810, 3879, 3786, 3845] 3658.0 3883.6 3749.0 3991.0 [3832, 3817, 3943, 3915, 3805, 3885, 3924, 3893, 3924, 3853, 3920, 3791, 3873, 3918, 3967, 3819, 3842, 3920, 3869, 3859, 3955, 3989, 3813, 3887, 3749, 3910, 3835, 3822, 3798, 3824, 3893, 3861, 3912, 3801, 3909, 3828, 3824, 3827, 3928, 3900, 3894, 3918, 3908, 3866, 3909, 3920, 3804, 3940, 3946, 3942, 3862, 3903, 3956, 3920, 3991, 3883, 3910, 3882, 3887, 3843, 3931, 3933, 3904, 3860, 3838, 3905, 3845, 3858, 3882, 3967, 3919, 3856, 3902, 3841, 3903, 3876, 3857, 3850, 3851, 3883, 3931, 3815, 3875, 3933, 3899, 3859, 3868, 3879, 3945, 3913, 3845, 3937, 3902, 3906, 3934, 3882, 3905, 3811, 3876, 3866] Eso-AdenoCA SBS3 C>T 91.0 98.0 91.71 95.29 0.9178507247707436 1.0 0.723 26154.0 Leading 1.077 1.039 1.036 91.0 91.71 80.0 107.0 [89, 82, 92, 100, 97, 85, 90, 88, 100, 89, 97, 89, 103, 87, 90, 90, 96, 102, 93, 103, 104, 96, 99, 94, 99, 83, 92, 102, 90, 89, 83, 91, 94, 96, 103, 92, 95, 89, 89, 82, 95, 88, 82, 87, 87, 82, 100, 90, 102, 81, 104, 88, 85, 89, 94, 96, 95, 90, 91, 84, 87, 88, 107, 87, 90, 91, 89, 80, 85, 100, 86, 96, 94, 95, 87, 90, 92, 90, 87, 83, 104, 101, 88, 83, 90, 92, 82, 97, 84, 92, 105, 86, 99, 83, 92, 98, 94, 95, 87, 81] 98.0 95.29 79.0 107.0 [98, 98, 92, 94, 90, 105, 99, 105, 85, 105, 90, 97, 87, 101, 97, 100, 91, 85, 94, 85, 88, 87, 88, 89, 86, 101, 100, 88, 97, 104, 100, 99, 98, 95, 91, 100, 89, 96, 104, 105, 94, 100, 107, 99, 95, 104, 89, 99, 88, 100, 86, 102, 100, 99, 94, 92, 92, 97, 98, 103, 97, 98, 79, 103, 101, 103, 95, 104, 100, 83, 95, 91, 93, 90, 100, 90, 94, 94, 95, 100, 89, 90, 99, 99, 99, 88, 100, 92, 104, 91, 80, 101, 86, 106, 103, 80, 93, 88, 92, 103] Eso-AdenoCA SBS3 T>A 2635.0 2662.0 2725.87 2659.92 0.3733853776279944 0.7760949333408065 20.253 26154.0 Leading 1.01 0.976 1.035 2635.0 2725.87 2631.0 2843.0 [2740, 2762, 2735, 2680, 2726, 2695, 2805, 2734, 2727, 2673, 2723, 2783, 2694, 2777, 2691, 2720, 2804, 2758, 2722, 2731, 2743, 2737, 2693, 2811, 2702, 2710, 2728, 2709, 2769, 2684, 2671, 2714, 2717, 2722, 2771, 2721, 2753, 2750, 2797, 2753, 2750, 2673, 2677, 2725, 2675, 2725, 2730, 2785, 2701, 2800, 2655, 2685, 2741, 2714, 2709, 2672, 2709, 2843, 2732, 2697, 2690, 2682, 2691, 2723, 2712, 2683, 2707, 2707, 2684, 2768, 2712, 2699, 2742, 2760, 2722, 2773, 2694, 2771, 2824, 2687, 2741, 2671, 2708, 2679, 2732, 2722, 2704, 2774, 2758, 2716, 2698, 2750, 2766, 2698, 2631, 2684, 2732, 2775, 2736, 2748] 2662.0 2659.92 2572.0 2763.0 [2656, 2653, 2614, 2705, 2653, 2663, 2611, 2650, 2619, 2712, 2664, 2618, 2662, 2645, 2671, 2676, 2604, 2648, 2646, 2651, 2671, 2669, 2689, 2614, 2703, 2644, 2687, 2642, 2662, 2730, 2702, 2670, 2639, 2678, 2625, 2639, 2599, 2606, 2614, 2637, 2619, 2730, 2657, 2658, 2716, 2658, 2655, 2622, 2704, 2598, 2725, 2669, 2642, 2668, 2677, 2716, 2683, 2572, 2640, 2695, 2726, 2711, 2679, 2667, 2650, 2710, 2688, 2627, 2729, 2648, 2667, 2678, 2648, 2632, 2656, 2618, 2646, 2637, 2594, 2673, 2639, 2714, 2706, 2718, 2651, 2658, 2673, 2619, 2603, 2641, 2689, 2639, 2612, 2682, 2763, 2717, 2641, 2603, 2646, 2649] Eso-AdenoCA SBS3 T>C 43.0 46.0 46.17 46.18 0.8821374153840177 1.0 0.34 26154.0 Leading 1.07 1.0 1.07 43.0 46.17 34.0 58.0 [43, 48, 43, 45, 48, 43, 47, 45, 34, 44, 48, 50, 47, 49, 48, 47, 53, 46, 44, 58, 38, 40, 52, 47, 50, 42, 52, 36, 50, 50, 40, 41, 41, 44, 46, 39, 56, 41, 46, 36, 51, 37, 46, 43, 45, 53, 41, 49, 49, 46, 39, 43, 45, 34, 46, 47, 49, 44, 43, 49, 41, 38, 42, 41, 50, 50, 48, 53, 50, 53, 50, 43, 53, 52, 51, 53, 45, 47, 36, 42, 42, 52, 46, 52, 57, 51, 54, 45, 46, 35, 50, 45, 54, 47, 55, 44, 44, 47, 54, 43] 46.0 46.18 34.0 61.0 [52, 45, 52, 45, 46, 47, 44, 43, 61, 54, 45, 41, 46, 48, 47, 48, 42, 47, 48, 37, 56, 52, 39, 42, 42, 56, 39, 57, 37, 43, 53, 52, 47, 46, 47, 57, 39, 53, 49, 57, 41, 56, 44, 46, 47, 42, 51, 43, 43, 44, 54, 47, 47, 60, 50, 43, 40, 53, 45, 41, 47, 49, 51, 50, 42, 37, 35, 38, 43, 45, 39, 45, 34, 40, 46, 42, 50, 45, 54, 52, 51, 42, 48, 40, 38, 41, 36, 45, 47, 58, 42, 47, 40, 50, 41, 48, 51, 43, 39, 49] Eso-AdenoCA SBS3 T>G 878.0 862.0 869.76 856.29 0.9729003075947988 1.0 6.653 26154.0 Lagging 1.019 1.016 1.003 878.0 869.76 807.0 921.0 [886, 894, 857, 838, 856, 882, 891, 843, 852, 881, 836, 875, 863, 835, 877, 833, 807, 887, 870, 838, 854, 887, 860, 878, 896, 892, 906, 876, 883, 883, 905, 899, 898, 905, 868, 851, 878, 885, 873, 872, 888, 849, 862, 869, 866, 872, 898, 841, 910, 883, 844, 853, 869, 871, 873, 876, 878, 879, 872, 867, 876, 892, 869, 866, 880, 873, 854, 921, 840, 870, 912, 878, 861, 844, 883, 843, 880, 889, 910, 873, 866, 846, 851, 867, 871, 851, 838, 854, 818, 886, 837, 853, 862, 886, 875, 875, 870, 838, 881, 867] 862.0 856.29 805.0 919.0 [848, 847, 855, 891, 858, 834, 821, 871, 864, 846, 883, 834, 866, 874, 856, 919, 906, 848, 882, 881, 888, 825, 863, 841, 856, 830, 821, 875, 838, 842, 822, 819, 827, 805, 870, 880, 846, 839, 858, 830, 843, 879, 862, 869, 853, 854, 838, 879, 819, 843, 871, 873, 864, 851, 845, 868, 841, 856, 849, 848, 877, 845, 860, 861, 861, 867, 878, 815, 883, 847, 809, 856, 862, 873, 830, 884, 853, 821, 819, 862, 878, 892, 880, 869, 861, 870, 875, 864, 891, 825, 895, 870, 856, 829, 870, 846, 852, 902, 826, 851] Head-SCC SBS3 C>A 2640.0 2743.0 2681.23 2752.46 0.7583007851618915 1.0 32.537 16544.0 Leading 1.039 1.027 1.012 2640.0 2681.23 2606.0 2788.0 [2663, 2707, 2681, 2650, 2705, 2709, 2746, 2782, 2654, 2788, 2675, 2614, 2689, 2651, 2667, 2706, 2700, 2711, 2646, 2649, 2625, 2735, 2701, 2626, 2665, 2655, 2719, 2687, 2741, 2646, 2699, 2649, 2741, 2653, 2677, 2735, 2718, 2687, 2653, 2703, 2656, 2645, 2728, 2738, 2626, 2697, 2706, 2642, 2726, 2709, 2704, 2659, 2698, 2631, 2663, 2743, 2639, 2664, 2632, 2684, 2756, 2659, 2610, 2685, 2657, 2701, 2649, 2606, 2653, 2642, 2671, 2670, 2610, 2719, 2722, 2656, 2617, 2641, 2646, 2659, 2660, 2692, 2649, 2694, 2607, 2661, 2724, 2659, 2758, 2692, 2743, 2652, 2670, 2696, 2704, 2724, 2662, 2785, 2695, 2669] 2743.0 2752.46 2629.0 2864.0 [2771, 2748, 2755, 2794, 2770, 2749, 2663, 2708, 2784, 2629, 2755, 2824, 2743, 2772, 2758, 2729, 2756, 2726, 2790, 2771, 2843, 2730, 2742, 2804, 2762, 2800, 2733, 2756, 2696, 2789, 2760, 2788, 2677, 2794, 2766, 2699, 2758, 2782, 2736, 2732, 2753, 2767, 2719, 2695, 2775, 2739, 2777, 2741, 2720, 2713, 2731, 2785, 2744, 2805, 2782, 2706, 2769, 2736, 2779, 2757, 2690, 2775, 2766, 2745, 2761, 2759, 2762, 2826, 2769, 2799, 2737, 2730, 2864, 2712, 2685, 2749, 2816, 2804, 2807, 2757, 2759, 2733, 2812, 2737, 2796, 2741, 2679, 2771, 2676, 2746, 2717, 2763, 2788, 2691, 2732, 2721, 2731, 2664, 2753, 2788] Head-SCC SBS3 C>G 1236.0 1163.0 1190.84 1214.61 0.16599961777110056 0.4290854712788672 14.501 16544.0 Lagging 1.063 0.98 1.084 1236.0 1190.84 1103.0 1252.0 [1201, 1200, 1174, 1252, 1192, 1165, 1172, 1179, 1159, 1220, 1162, 1168, 1192, 1189, 1226, 1159, 1219, 1188, 1219, 1246, 1163, 1103, 1209, 1173, 1210, 1131, 1231, 1194, 1185, 1194, 1185, 1185, 1160, 1199, 1195, 1218, 1182, 1198, 1212, 1161, 1220, 1187, 1205, 1204, 1209, 1200, 1199, 1215, 1197, 1221, 1177, 1175, 1166, 1189, 1178, 1160, 1162, 1239, 1218, 1178, 1188, 1215, 1205, 1163, 1156, 1207, 1169, 1149, 1208, 1173, 1191, 1171, 1218, 1207, 1187, 1177, 1181, 1197, 1156, 1208, 1197, 1165, 1202, 1217, 1211, 1190, 1202, 1163, 1197, 1209, 1220, 1169, 1227, 1169, 1206, 1189, 1200, 1162, 1197, 1197] 1163.0 1214.61 1173.0 1313.0 [1197, 1216, 1234, 1178, 1212, 1226, 1227, 1240, 1218, 1179, 1232, 1222, 1207, 1219, 1196, 1243, 1199, 1212, 1193, 1173, 1254, 1313, 1204, 1232, 1190, 1260, 1202, 1196, 1230, 1201, 1217, 1219, 1227, 1210, 1212, 1191, 1232, 1226, 1185, 1249, 1205, 1232, 1176, 1192, 1191, 1193, 1201, 1206, 1232, 1196, 1225, 1235, 1249, 1211, 1213, 1231, 1239, 1197, 1185, 1233, 1228, 1189, 1183, 1241, 1250, 1195, 1239, 1259, 1198, 1225, 1232, 1226, 1194, 1201, 1232, 1222, 1203, 1214, 1251, 1195, 1198, 1248, 1176, 1186, 1173, 1220, 1211, 1243, 1218, 1199, 1194, 1200, 1190, 1251, 1196, 1209, 1200, 1231, 1224, 1202] Head-SCC SBS3 C>T 682.0 695.0 683.91 699.93 0.9696321740807964 1.0 8.323 16544.0 Leading 1.019 1.023 0.996 682.0 683.91 633.0 728.0 [692, 667, 674, 678, 678, 661, 671, 673, 677, 668, 687, 704, 718, 662, 691, 678, 694, 680, 701, 663, 709, 672, 652, 707, 691, 644, 700, 641, 712, 712, 675, 677, 671, 691, 693, 686, 691, 693, 664, 687, 712, 701, 659, 695, 656, 703, 700, 662, 685, 728, 690, 690, 668, 668, 708, 659, 687, 697, 661, 675, 688, 707, 694, 701, 681, 714, 680, 665, 643, 665, 633, 681, 686, 671, 722, 668, 686, 675, 683, 711, 689, 709, 682, 681, 655, 697, 707, 692, 699, 711, 665, 666, 691, 695, 691, 663, 664, 711, 696, 684] 695.0 699.93 665.0 739.0 [703, 718, 702, 699, 688, 726, 720, 717, 693, 716, 702, 683, 665, 733, 694, 699, 670, 694, 692, 716, 682, 698, 735, 677, 686, 726, 673, 739, 676, 683, 717, 705, 712, 693, 678, 694, 712, 706, 698, 690, 683, 683, 709, 701, 726, 673, 688, 701, 713, 669, 694, 694, 724, 736, 678, 736, 703, 687, 710, 692, 684, 682, 696, 682, 705, 687, 714, 714, 724, 710, 736, 687, 706, 724, 673, 722, 694, 701, 712, 683, 685, 669, 687, 722, 721, 684, 665, 703, 693, 678, 717, 717, 688, 697, 687, 729, 720, 682, 686, 717] Head-SCC SBS3 T>A 2291.0 2342.0 2368.31 2296.66 0.20579092565555576 0.5046968860315616 28.004 16544.0 Leading 1.022 0.97 1.054 2291.0 2368.31 2275.0 2481.0 [2400, 2299, 2406, 2304, 2372, 2481, 2393, 2416, 2378, 2413, 2367, 2348, 2400, 2393, 2348, 2376, 2371, 2381, 2374, 2385, 2345, 2349, 2377, 2446, 2365, 2417, 2364, 2380, 2371, 2386, 2349, 2335, 2348, 2454, 2393, 2420, 2295, 2344, 2398, 2436, 2397, 2432, 2385, 2300, 2386, 2342, 2370, 2327, 2344, 2412, 2334, 2368, 2380, 2373, 2353, 2337, 2402, 2326, 2381, 2363, 2301, 2342, 2335, 2396, 2351, 2403, 2397, 2359, 2359, 2332, 2384, 2403, 2354, 2281, 2323, 2384, 2275, 2363, 2336, 2365, 2351, 2384, 2399, 2330, 2375, 2382, 2377, 2343, 2356, 2377, 2358, 2334, 2370, 2347, 2339, 2415, 2386, 2377, 2359, 2340] 2342.0 2296.66 2202.0 2394.0 [2276, 2374, 2260, 2335, 2292, 2202, 2276, 2262, 2299, 2297, 2303, 2274, 2259, 2289, 2304, 2264, 2295, 2296, 2296, 2290, 2298, 2328, 2288, 2222, 2273, 2225, 2282, 2283, 2308, 2270, 2307, 2341, 2318, 2224, 2262, 2228, 2368, 2296, 2238, 2238, 2276, 2284, 2289, 2368, 2297, 2286, 2294, 2332, 2358, 2279, 2335, 2279, 2275, 2285, 2304, 2354, 2281, 2327, 2292, 2333, 2339, 2336, 2296, 2280, 2312, 2272, 2237, 2313, 2279, 2308, 2271, 2226, 2337, 2394, 2322, 2275, 2340, 2318, 2356, 2285, 2298, 2308, 2296, 2330, 2307, 2276, 2267, 2339, 2317, 2324, 2305, 2344, 2287, 2355, 2314, 2256, 2298, 2281, 2297, 2303] Head-SCC SBS3 T>C 434.0 467.0 467.72 456.62 0.30322254949230193 0.6734901792084325 5.446 16544.0 Leading 1.076 0.976 1.102 1 434.0 467.72 430.0 501.0 [466, 444, 454, 462, 475, 472, 448, 481, 473, 466, 485, 448, 486, 465, 466, 430, 470, 442, 446, 492, 448, 459, 495, 498, 463, 479, 446, 446, 495, 477, 465, 483, 468, 478, 469, 478, 486, 478, 467, 470, 447, 481, 474, 475, 476, 455, 449, 478, 439, 491, 480, 486, 478, 446, 483, 481, 461, 492, 481, 443, 453, 435, 465, 487, 467, 480, 448, 464, 492, 501, 477, 458, 478, 455, 465, 464, 469, 466, 453, 485, 467, 434, 460, 456, 497, 486, 450, 453, 481, 463, 470, 479, 460, 459, 465, 484, 449, 472, 459, 451] 467.0 456.62 406.0 498.0 [461, 488, 461, 461, 453, 450, 463, 454, 456, 471, 434, 458, 440, 459, 450, 498, 456, 479, 486, 435, 483, 467, 406, 433, 472, 440, 475, 465, 431, 449, 470, 434, 466, 439, 451, 454, 435, 435, 446, 455, 487, 449, 446, 439, 442, 476, 478, 452, 489, 452, 458, 445, 450, 462, 442, 444, 477, 444, 440, 482, 473, 485, 458, 436, 455, 452, 476, 457, 442, 415, 445, 474, 442, 467, 444, 460, 447, 450, 485, 448, 467, 473, 473, 474, 407, 448, 475, 477, 457, 458, 449, 436, 462, 460, 467, 444, 457, 452, 462, 480] Head-SCC SBS3 T>G 989.0 862.0 948.37 926.78 0.08810652134811045 0.25648938633565077 11.188 16544.0 Lagging 1.147 1.023 1.121 1 989.0 948.37 900.0 997.0 [970, 970, 966, 948, 932, 907, 937, 959, 974, 927, 944, 936, 919, 963, 943, 963, 956, 968, 935, 933, 952, 988, 997, 940, 940, 969, 924, 938, 921, 945, 941, 977, 933, 932, 921, 994, 941, 948, 945, 923, 942, 917, 939, 963, 932, 926, 936, 944, 958, 948, 960, 969, 971, 948, 931, 900, 916, 997, 943, 937, 980, 969, 935, 922, 942, 941, 932, 945, 925, 915, 939, 973, 962, 904, 970, 942, 963, 961, 948, 944, 967, 955, 900, 920, 969, 910, 975, 979, 949, 991, 986, 926, 961, 952, 935, 977, 989, 982, 933, 973] 862.0 926.78 854.0 975.0 [887, 915, 924, 895, 937, 958, 905, 917, 881, 941, 904, 930, 967, 918, 934, 911, 931, 907, 928, 951, 900, 901, 905, 944, 935, 898, 948, 942, 950, 952, 933, 891, 919, 948, 947, 893, 943, 911, 905, 947, 936, 954, 928, 897, 957, 932, 944, 940, 909, 924, 927, 908, 920, 925, 943, 975, 935, 854, 959, 947, 922, 937, 940, 959, 934, 946, 939, 936, 951, 960, 926, 895, 928, 967, 921, 933, 902, 896, 925, 891, 933, 936, 953, 953, 923, 964, 904, 908, 933, 885, 889, 960, 919, 936, 940, 925, 892, 902, 940, 908] Liver-HCC SBS3 C>A 453.0 524.0 489.21 505.3 0.22338942671927475 0.5356511587851738 25.245 3870.0 Leading 1.157 1.033 1.12 1 453.0 489.21 450.0 523.0 [481, 466, 497, 462, 489, 474, 519, 485, 523, 498, 479, 460, 502, 482, 465, 507, 488, 490, 450, 501, 511, 507, 496, 504, 511, 490, 499, 518, 485, 475, 490, 490, 500, 494, 486, 483, 477, 450, 514, 476, 505, 495, 501, 511, 496, 485, 491, 463, 482, 465, 509, 489, 517, 488, 492, 500, 456, 461, 505, 470, 485, 478, 507, 468, 493, 463, 504, 474, 461, 521, 484, 490, 520, 502, 500, 469, 485, 499, 490, 480, 483, 480, 500, 506, 474, 500, 503, 515, 490, 474, 485, 479, 477, 508, 474, 499, 492, 470, 465, 519] 524.0 505.3 469.0 539.0 [527, 539, 498, 530, 503, 517, 488, 515, 486, 494, 518, 523, 481, 511, 527, 497, 501, 493, 530, 485, 493, 488, 488, 504, 490, 518, 503, 486, 499, 521, 499, 513, 493, 487, 500, 503, 521, 534, 469, 518, 488, 505, 494, 488, 491, 511, 485, 522, 502, 533, 501, 504, 486, 518, 512, 483, 534, 529, 500, 526, 513, 515, 493, 528, 512, 533, 472, 521, 528, 477, 507, 507, 489, 506, 504, 525, 502, 503, 503, 505, 506, 511, 496, 497, 522, 496, 492, 486, 500, 519, 503, 508, 511, 490, 522, 490, 498, 522, 532, 484] Liver-HCC SBS3 C>G 513.0 532.0 521.01 529.74 0.8270839979690203 1.0 27.003 3870.0 Leading 1.037 1.017 1.02 513.0 521.01 466.0 560.0 [560, 507, 512, 541, 530, 527, 544, 546, 526, 534, 543, 502, 531, 498, 516, 502, 546, 509, 534, 510, 503, 521, 495, 524, 560, 535, 466, 510, 533, 520, 499, 532, 504, 539, 506, 530, 497, 496, 506, 527, 493, 499, 550, 517, 495, 543, 532, 512, 549, 523, 521, 535, 505, 528, 523, 535, 526, 536, 531, 496, 516, 514, 507, 506, 549, 515, 532, 548, 524, 517, 524, 514, 508, 532, 541, 504, 529, 527, 503, 522, 515, 502, 519, 546, 533, 519, 511, 490, 507, 537, 535, 533, 516, 528, 506, 540, 509, 510, 524, 519] 532.0 529.74 497.0 568.0 [499, 552, 550, 510, 541, 511, 517, 504, 533, 524, 505, 552, 514, 558, 537, 558, 522, 542, 522, 545, 549, 538, 566, 514, 500, 516, 568, 533, 511, 522, 549, 523, 531, 514, 546, 529, 550, 547, 541, 521, 561, 543, 497, 545, 552, 506, 529, 527, 504, 525, 539, 501, 546, 506, 534, 519, 520, 507, 518, 543, 521, 527, 540, 528, 512, 542, 520, 509, 534, 542, 536, 542, 527, 524, 508, 528, 527, 531, 543, 526, 546, 555, 546, 499, 520, 532, 537, 559, 542, 516, 505, 518, 526, 531, 532, 509, 534, 544, 527, 543] Liver-HCC SBS3 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3870.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS3 T>A 891.0 862.0 888.58 862.78 0.9730447893647759 1.0 45.297 3870.0 Lagging 1.034 1.03 1.004 891.0 888.58 837.0 952.0 [837, 867, 906, 879, 849, 872, 865, 879, 878, 867, 861, 900, 934, 853, 885, 894, 865, 889, 894, 895, 871, 889, 904, 927, 867, 867, 866, 888, 938, 888, 892, 912, 872, 891, 866, 891, 905, 898, 865, 931, 907, 873, 912, 870, 871, 952, 888, 903, 916, 863, 912, 860, 898, 895, 884, 905, 892, 910, 886, 889, 885, 860, 877, 934, 876, 894, 854, 890, 900, 873, 868, 863, 872, 896, 899, 879, 875, 894, 870, 902, 902, 896, 852, 862, 864, 927, 908, 901, 900, 855, 900, 875, 938, 915, 889, 909, 860, 941, 893, 927] 862.0 862.78 798.0 921.0 [898, 880, 839, 859, 897, 865, 891, 879, 862, 895, 893, 851, 811, 897, 854, 886, 886, 860, 849, 873, 865, 861, 837, 826, 905, 871, 877, 870, 798, 861, 865, 841, 886, 860, 888, 881, 842, 856, 885, 821, 860, 872, 837, 871, 891, 812, 864, 843, 838, 880, 833, 879, 832, 829, 874, 849, 867, 854, 859, 853, 868, 880, 869, 807, 873, 878, 894, 867, 871, 880, 870, 867, 863, 834, 866, 875, 873, 860, 899, 849, 844, 878, 921, 886, 867, 831, 833, 863, 874, 898, 849, 898, 816, 841, 869, 849, 896, 808, 873, 823] Liver-HCC SBS3 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3870.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS3 T>G 49.0 46.0 47.59 46.36 1.0 1.0 2.455 3870.0 Lagging 1.065 1.027 1.038 49.0 47.59 33.0 56.0 [45, 43, 55, 44, 49, 43, 48, 45, 43, 50, 42, 45, 56, 42, 50, 49, 53, 56, 45, 42, 51, 39, 52, 50, 53, 53, 43, 45, 41, 42, 41, 54, 45, 41, 44, 47, 50, 46, 50, 50, 47, 52, 45, 52, 53, 51, 52, 50, 56, 52, 48, 48, 45, 52, 42, 45, 50, 43, 50, 55, 47, 52, 49, 46, 54, 48, 47, 41, 44, 46, 45, 47, 53, 49, 49, 49, 49, 46, 49, 46, 51, 52, 44, 49, 45, 43, 44, 47, 47, 49, 33, 55, 42, 52, 47, 44, 41, 46, 54, 48] 46.0 46.36 36.0 59.0 [49, 54, 40, 50, 45, 54, 42, 46, 54, 47, 48, 46, 38, 49, 44, 45, 42, 36, 51, 53, 43, 52, 43, 45, 42, 38, 54, 45, 52, 51, 52, 45, 46, 52, 47, 47, 41, 45, 45, 38, 47, 41, 50, 42, 45, 41, 43, 42, 39, 45, 49, 49, 46, 41, 50, 49, 45, 50, 47, 37, 42, 43, 47, 49, 43, 48, 46, 47, 49, 50, 50, 45, 42, 46, 46, 42, 46, 47, 47, 47, 44, 43, 52, 46, 48, 55, 51, 50, 42, 44, 59, 41, 50, 44, 47, 48, 57, 50, 42, 47] Lung-AdenoCA SBS3 C>A 893.0 934.0 903.63 925.6 0.7659069869190804 1.0 25.259 7233.0 Leading 1.046 1.024 1.021 893.0 903.63 841.0 960.0 [876, 862, 923, 914, 841, 952, 910, 905, 936, 892, 897, 900, 890, 912, 894, 873, 904, 936, 940, 934, 891, 932, 899, 910, 927, 922, 952, 873, 879, 901, 924, 908, 919, 960, 906, 889, 901, 914, 898, 893, 876, 906, 897, 913, 919, 897, 918, 923, 883, 882, 901, 879, 915, 920, 912, 874, 929, 888, 910, 862, 898, 893, 863, 922, 868, 918, 894, 898, 911, 869, 868, 894, 886, 900, 901, 902, 928, 920, 928, 947, 881, 886, 906, 922, 897, 915, 952, 917, 927, 916, 876, 870, 907, 911, 863, 903, 887, 905, 903, 918] 934.0 925.6 869.0 984.0 [953, 955, 916, 904, 984, 869, 917, 926, 897, 962, 944, 941, 923, 914, 939, 946, 929, 883, 895, 898, 940, 896, 935, 915, 904, 907, 883, 951, 949, 917, 905, 921, 912, 896, 911, 958, 945, 919, 942, 952, 967, 933, 921, 921, 907, 942, 909, 891, 956, 941, 939, 965, 916, 901, 914, 934, 927, 939, 909, 961, 909, 922, 938, 908, 956, 904, 915, 931, 911, 939, 961, 948, 927, 951, 937, 936, 889, 898, 883, 887, 940, 939, 938, 922, 912, 918, 896, 915, 908, 918, 952, 964, 925, 919, 962, 929, 962, 918, 923, 904] Lung-AdenoCA SBS3 C>G 452.0 401.0 426.26 433.41 0.1612408176995192 0.4200512864966036 11.793 7233.0 Lagging 1.127 0.984 1.146 1 452.0 426.26 388.0 463.0 [395, 408, 438, 409, 431, 452, 398, 399, 406, 423, 441, 429, 430, 414, 429, 410, 420, 429, 429, 409, 441, 411, 435, 422, 395, 427, 456, 424, 436, 422, 451, 435, 457, 426, 443, 413, 425, 428, 408, 435, 437, 417, 418, 428, 425, 446, 388, 424, 416, 416, 423, 424, 407, 436, 449, 418, 428, 421, 443, 433, 413, 432, 431, 431, 460, 433, 410, 408, 463, 439, 446, 428, 435, 414, 422, 405, 440, 453, 415, 427, 433, 390, 431, 407, 453, 419, 396, 446, 428, 440, 425, 419, 417, 429, 434, 447, 424, 423, 445, 429] 401.0 433.41 388.0 475.0 [447, 427, 422, 452, 425, 411, 460, 469, 447, 434, 421, 440, 439, 441, 429, 447, 438, 425, 432, 452, 409, 443, 431, 442, 457, 437, 416, 439, 424, 443, 413, 426, 420, 427, 412, 444, 434, 435, 449, 437, 419, 436, 438, 434, 428, 412, 475, 457, 439, 449, 441, 432, 449, 428, 420, 448, 438, 422, 410, 438, 440, 440, 429, 420, 407, 421, 446, 443, 388, 434, 411, 433, 414, 441, 446, 453, 427, 416, 437, 430, 437, 474, 429, 451, 402, 435, 451, 417, 427, 422, 437, 433, 449, 422, 437, 430, 433, 436, 404, 430] Lung-AdenoCA SBS3 C>T 487.0 452.0 465.45 473.59 0.3324137132757393 0.7170466451095877 12.982 7233.0 Lagging 1.077 0.983 1.096 1 487.0 465.45 430.0 496.0 [459, 480, 471, 481, 462, 458, 461, 479, 480, 472, 472, 465, 488, 477, 470, 479, 457, 476, 481, 430, 481, 453, 445, 489, 448, 457, 448, 466, 469, 448, 449, 477, 481, 459, 471, 467, 462, 486, 475, 476, 487, 484, 450, 441, 463, 468, 455, 464, 432, 451, 476, 495, 466, 469, 460, 463, 462, 450, 482, 477, 477, 436, 492, 481, 470, 467, 466, 456, 485, 451, 462, 459, 453, 455, 461, 438, 471, 447, 490, 440, 467, 485, 473, 496, 485, 491, 446, 477, 463, 477, 451, 437, 443, 451, 471, 449, 453, 466, 455, 452] 452.0 473.59 440.0 518.0 [489, 463, 466, 463, 482, 482, 487, 453, 464, 464, 468, 465, 448, 473, 473, 476, 485, 455, 457, 518, 451, 477, 499, 454, 479, 481, 489, 478, 473, 477, 492, 445, 464, 470, 478, 474, 469, 462, 467, 475, 449, 460, 496, 487, 456, 478, 475, 476, 512, 477, 465, 448, 481, 478, 485, 470, 475, 491, 458, 468, 462, 498, 440, 450, 474, 473, 469, 479, 440, 480, 484, 458, 487, 484, 474, 512, 461, 491, 461, 489, 488, 451, 469, 446, 451, 449, 495, 471, 472, 471, 498, 501, 488, 485, 479, 488, 476, 475, 496, 474] Lung-AdenoCA SBS3 T>A 723.0 793.0 768.38 750.68 0.11028551152109044 0.3084991499257037 20.959 7233.0 Leading 1.097 0.977 1.123 1 723.0 768.38 723.0 834.0 [740, 763, 786, 834, 782, 773, 768, 763, 765, 783, 771, 782, 741, 774, 764, 795, 762, 732, 786, 747, 763, 746, 739, 769, 787, 754, 788, 774, 731, 757, 766, 776, 786, 790, 763, 727, 747, 748, 792, 782, 766, 772, 801, 779, 766, 778, 732, 790, 774, 798, 752, 774, 733, 778, 784, 737, 742, 765, 778, 782, 760, 783, 756, 805, 738, 753, 813, 788, 811, 761, 768, 754, 727, 731, 755, 774, 764, 793, 761, 767, 780, 791, 770, 778, 806, 748, 784, 766, 752, 748, 723, 782, 792, 771, 732, 781, 786, 753, 793, 763] 793.0 750.68 691.0 802.0 [798, 747, 747, 713, 747, 750, 750, 742, 732, 741, 743, 736, 775, 745, 757, 732, 758, 788, 736, 759, 750, 764, 770, 769, 734, 769, 736, 740, 795, 777, 755, 739, 740, 719, 749, 792, 772, 766, 727, 729, 747, 733, 698, 754, 769, 757, 794, 735, 737, 704, 763, 743, 787, 734, 741, 794, 791, 767, 724, 730, 764, 735, 764, 704, 776, 766, 719, 746, 691, 769, 740, 755, 794, 782, 757, 746, 749, 721, 754, 752, 760, 734, 732, 743, 701, 775, 729, 742, 756, 762, 778, 749, 739, 750, 802, 723, 740, 763, 743, 773] Lung-AdenoCA SBS3 T>C 500.0 523.0 515.78 500.41 0.42519292321393776 0.8459692297958998 14.144 7233.0 Leading 1.046 0.97 1.078 500.0 515.78 460.0 561.0 [483, 512, 546, 527, 516, 533, 499, 531, 524, 497, 483, 482, 518, 532, 520, 527, 482, 512, 519, 481, 553, 505, 524, 525, 494, 496, 505, 533, 547, 523, 497, 542, 500, 493, 520, 531, 513, 497, 528, 501, 530, 501, 525, 515, 500, 541, 523, 511, 526, 511, 499, 549, 506, 508, 502, 545, 526, 509, 497, 503, 536, 530, 492, 535, 502, 536, 531, 521, 521, 493, 514, 520, 500, 518, 514, 501, 507, 504, 513, 561, 548, 501, 539, 537, 460, 538, 507, 529, 533, 536, 494, 530, 499, 511, 502, 538, 519, 516, 503, 511] 523.0 500.41 457.0 545.0 [523, 505, 474, 495, 496, 491, 518, 498, 517, 519, 532, 533, 503, 488, 490, 478, 533, 502, 495, 532, 457, 505, 482, 484, 520, 516, 505, 471, 471, 508, 517, 473, 527, 519, 489, 489, 515, 517, 490, 507, 492, 511, 495, 501, 521, 478, 484, 482, 495, 511, 517, 465, 512, 498, 520, 472, 497, 513, 517, 521, 487, 480, 517, 492, 505, 485, 487, 493, 507, 534, 491, 502, 514, 494, 501, 504, 505, 510, 505, 461, 476, 521, 483, 480, 545, 486, 514, 489, 474, 480, 514, 493, 510, 504, 510, 491, 487, 509, 516, 499] Lung-AdenoCA SBS3 T>G 556.0 519.0 542.55 531.7 0.6044912394468339 1.0 14.862 7233.0 Lagging 1.071 1.02 1.05 556.0 542.55 503.0 583.0 [544, 534, 562, 533, 553, 534, 523, 529, 542, 579, 563, 550, 575, 515, 544, 550, 578, 548, 521, 572, 555, 512, 535, 550, 558, 554, 544, 544, 520, 548, 547, 518, 550, 522, 522, 503, 533, 538, 552, 544, 572, 543, 536, 537, 550, 537, 533, 580, 528, 533, 512, 526, 551, 544, 553, 520, 513, 553, 543, 544, 541, 503, 542, 550, 541, 528, 517, 556, 567, 553, 526, 542, 537, 560, 532, 576, 530, 561, 583, 550, 532, 534, 557, 543, 542, 553, 549, 522, 542, 565, 544, 571, 523, 547, 545, 534, 521, 531, 578, 521] 519.0 531.7 494.0 579.0 [525, 555, 514, 555, 513, 532, 550, 545, 534, 497, 510, 528, 502, 557, 540, 511, 500, 522, 562, 497, 537, 555, 536, 527, 513, 525, 539, 530, 540, 536, 524, 558, 525, 551, 554, 579, 542, 539, 512, 539, 505, 537, 545, 546, 530, 530, 541, 498, 548, 533, 540, 548, 531, 525, 514, 547, 556, 511, 538, 535, 528, 555, 517, 520, 534, 551, 556, 519, 516, 517, 553, 529, 533, 500, 538, 517, 537, 518, 496, 530, 547, 539, 532, 535, 533, 525, 536, 535, 542, 513, 527, 510, 553, 511, 533, 533, 560, 539, 494, 541] Ovary-AdenoCA SBS3 C>A 42309.0 43661.0 42638.22 43564.15 0.3022723358377448 0.6720410821820456 21.949 391686.0 Leading 1.032 1.022 1.01 42309.0 42638.22 42150.0 43057.0 [42657, 42482, 42589, 42771, 42430, 42760, 42534, 42441, 42602, 42766, 42640, 42668, 42986, 42418, 42704, 42543, 42626, 43006, 43057, 42620, 42797, 42561, 42804, 42469, 42689, 42491, 42518, 42700, 42691, 42668, 42678, 42597, 42675, 42678, 42679, 42417, 42433, 42598, 42775, 42620, 42569, 42758, 42754, 42656, 42849, 42438, 42150, 42701, 42602, 42448, 42798, 42775, 42577, 42798, 42746, 42661, 42564, 42538, 42614, 42570, 42632, 42508, 42496, 42622, 42698, 42427, 42727, 42534, 42833, 42640, 42932, 42568, 42469, 42631, 42641, 42738, 42436, 42768, 42759, 42348, 42559, 42566, 42908, 42681, 42928, 42392, 42714, 42540, 42582, 42781, 42533, 42499, 42376, 42672, 42717, 42810, 42683, 42672, 42827, 42571] 43661.0 43564.15 43174.0 43975.0 [43523, 43841, 43548, 43457, 43765, 43278, 43556, 43774, 43564, 43603, 43475, 43448, 43338, 43816, 43461, 43625, 43571, 43279, 43219, 43734, 43499, 43669, 43483, 43691, 43416, 43742, 43801, 43427, 43420, 43677, 43568, 43624, 43526, 43410, 43541, 43938, 43761, 43575, 43510, 43648, 43602, 43408, 43507, 43631, 43473, 43644, 43975, 43503, 43537, 43648, 43382, 43482, 43546, 43432, 43572, 43578, 43401, 43452, 43660, 43578, 43463, 43696, 43733, 43602, 43485, 43672, 43479, 43698, 43264, 43536, 43174, 43699, 43564, 43638, 43589, 43390, 43607, 43466, 43599, 43884, 43643, 43610, 43298, 43593, 43284, 43700, 43578, 43708, 43537, 43625, 43677, 43743, 43842, 43568, 43537, 43523, 43525, 43589, 43312, 43473] Ovary-AdenoCA SBS3 C>G 44420.0 40377.0 42154.96 42727.16 3.6794656121464473e-29 3.575377547967928e-28 21.649 391686.0 Lagging 1.1 0.987 1.115 1 44420.0 42154.96 41786.0 42551.0 [42065, 41959, 41902, 42075, 42161, 42195, 42135, 42301, 42460, 42258, 42228, 42192, 42412, 42446, 42192, 42022, 42117, 42211, 42239, 42161, 42187, 42385, 41991, 42052, 41990, 42307, 42171, 42219, 42104, 42127, 42255, 41786, 41937, 42033, 42338, 42069, 42129, 42077, 42026, 42253, 42454, 42137, 42032, 42312, 42345, 42068, 42551, 42177, 42023, 42183, 42358, 42037, 42202, 42267, 42427, 42000, 42230, 42068, 41944, 42086, 42105, 42317, 42323, 42014, 42271, 42171, 42150, 41863, 42197, 42137, 42099, 42075, 42068, 42185, 41888, 42189, 42108, 41945, 42123, 42159, 42228, 42049, 42219, 41949, 42189, 42227, 42238, 42082, 42201, 42227, 42264, 42199, 42358, 42122, 42420, 42182, 42055, 41928, 41898, 42006] 40377.0 42727.16 42350.0 43122.0 [42921, 42926, 43003, 42714, 42590, 42618, 42580, 42689, 42527, 42471, 42694, 42751, 42507, 42372, 42699, 42856, 42796, 42678, 42669, 42889, 42738, 42620, 42643, 42706, 42807, 42646, 42777, 42813, 42750, 42712, 42620, 43122, 43023, 42936, 42678, 42712, 42705, 42927, 42947, 42737, 42443, 42725, 42790, 42666, 42477, 42883, 42350, 42794, 42781, 42723, 42624, 42789, 42569, 42763, 42387, 42799, 42528, 42800, 42890, 42651, 42739, 42686, 42391, 42906, 42676, 42732, 42764, 42967, 42763, 42813, 42785, 42747, 42616, 42864, 42986, 42711, 42794, 42855, 42802, 42704, 42628, 42829, 42818, 42805, 42503, 42474, 42682, 42761, 42772, 42686, 42666, 42811, 42542, 42835, 42525, 42723, 42644, 42881, 42835, 42994] Ovary-AdenoCA SBS3 C>T 20675.0 19585.0 20041.39 20383.33 4.6135245068720723e-07 2.495808542468228e-06 10.279 391686.0 Lagging 1.056 0.983 1.074 20675.0 20041.39 19792.0 20386.0 [19949, 19921, 19930, 19974, 19912, 20133, 20386, 20059, 20049, 20079, 20197, 20099, 20021, 20019, 19939, 20058, 19977, 20029, 20060, 20121, 20031, 19997, 19925, 20014, 20063, 20149, 20067, 19957, 20115, 20100, 20076, 20111, 19894, 20279, 20059, 19858, 20386, 19865, 19989, 19873, 19977, 19859, 20124, 19958, 20221, 20022, 19983, 20119, 20236, 20052, 19983, 19871, 19975, 19963, 19998, 20073, 19850, 19939, 19987, 20070, 20221, 20004, 20229, 19842, 20006, 19940, 20017, 19967, 20137, 20057, 19792, 20221, 20007, 20108, 20014, 20086, 20038, 19930, 20048, 20242, 20119, 20040, 19891, 20046, 20099, 20100, 19985, 20094, 20114, 20015, 20303, 19967, 20163, 19994, 20079, 20317, 19891, 19861, 20190, 19985] 19585.0 20383.33 20022.0 20701.0 [20483, 20539, 20426, 20322, 20354, 20303, 20102, 20475, 20408, 20273, 20229, 20263, 20372, 20383, 20486, 20322, 20539, 20395, 20384, 20336, 20415, 20491, 20470, 20444, 20408, 20225, 20379, 20499, 20336, 20306, 20422, 20298, 20471, 20189, 20377, 20561, 20022, 20557, 20341, 20545, 20517, 20491, 20307, 20423, 20264, 20459, 20432, 20312, 20140, 20328, 20375, 20511, 20441, 20452, 20460, 20352, 20701, 20552, 20389, 20380, 20220, 20411, 20176, 20565, 20445, 20532, 20398, 20550, 20338, 20336, 20497, 20242, 20407, 20387, 20397, 20153, 20386, 20529, 20374, 20208, 20247, 20363, 20511, 20397, 20340, 20359, 20477, 20335, 20346, 20367, 20184, 20434, 20181, 20468, 20334, 20185, 20619, 20508, 20298, 20393] Ovary-AdenoCA SBS3 T>A 43740.0 43808.0 44456.53 43367.33 0.005856237970751245 0.022031073670925373 22.352 391686.0 Leading 1.002 0.975 1.027 43740.0 44456.53 44012.0 44846.0 [44390, 44470, 44653, 44457, 44353, 44615, 44399, 44286, 44513, 44528, 44185, 44496, 44537, 44596, 44662, 44552, 44522, 44347, 44422, 44721, 44381, 44576, 44361, 44345, 44298, 44581, 44485, 44524, 44408, 44592, 44290, 44376, 44169, 44204, 44789, 44443, 44693, 44346, 44532, 44444, 44130, 44374, 44607, 44228, 44649, 44341, 44417, 44640, 44337, 44694, 44283, 44846, 44310, 44524, 44358, 44220, 44239, 44450, 44634, 44623, 44752, 44359, 44561, 44638, 44306, 44535, 44306, 44546, 44558, 44656, 44458, 44365, 44429, 44430, 44609, 44413, 44513, 44124, 44263, 44321, 44415, 44476, 44436, 44512, 44363, 44418, 44313, 44012, 44810, 44444, 44413, 44310, 44479, 44725, 44386, 44385, 44529, 44498, 44503, 44639] 43808.0 43367.33 43031.0 43698.0 [43380, 43346, 43148, 43304, 43444, 43193, 43309, 43517, 43201, 43370, 43629, 43457, 43151, 43102, 43152, 43204, 43291, 43254, 43359, 43101, 43410, 43259, 43511, 43438, 43513, 43316, 43234, 43369, 43381, 43397, 43488, 43480, 43604, 43545, 43031, 43305, 43254, 43441, 43379, 43482, 43593, 43324, 43222, 43670, 43310, 43381, 43466, 43397, 43431, 43167, 43540, 43127, 43333, 43406, 43417, 43650, 43522, 43436, 43166, 43253, 43119, 43590, 43198, 43250, 43504, 43125, 43468, 43440, 43183, 43271, 43302, 43551, 43338, 43319, 43190, 43454, 43379, 43662, 43464, 43452, 43471, 43395, 43352, 43535, 43557, 43336, 43521, 43698, 43061, 43398, 43415, 43496, 43312, 43162, 43421, 43419, 43359, 43326, 43423, 43257] Ovary-AdenoCA SBS3 T>C 26578.0 26280.0 26791.36 26167.24 0.319222152671204 0.6980513829986991 13.495 391686.0 Lagging 1.011 1.024 0.988 26578.0 26791.36 26461.0 27126.0 [26603, 26817, 26825, 26774, 26759, 26662, 26796, 26797, 26920, 26598, 26676, 26694, 26889, 26961, 27007, 26960, 26619, 27011, 26811, 26864, 26829, 26713, 26760, 26871, 26881, 26880, 26863, 26523, 26751, 26469, 26731, 26944, 26774, 26763, 26809, 26791, 26825, 26669, 26821, 26842, 26742, 26804, 26642, 26949, 26888, 26806, 26943, 26708, 26990, 26889, 27021, 26929, 26866, 26645, 26786, 26854, 26701, 26760, 26642, 26687, 26839, 26719, 26728, 26798, 26672, 26824, 26649, 26914, 26921, 26534, 26982, 26895, 26776, 26997, 26772, 26539, 26812, 26659, 26736, 26674, 26763, 26812, 26676, 26617, 26736, 26818, 26582, 27014, 27013, 26511, 26797, 26966, 26461, 26918, 26799, 27126, 26675, 26824, 26940, 26844] 26280.0 26167.24 25835.0 26440.0 [26368, 26166, 26065, 26163, 26241, 26298, 26110, 26180, 25952, 26279, 26243, 26313, 26083, 25999, 25886, 26091, 26407, 25993, 26158, 26091, 26027, 26178, 26179, 26076, 25985, 26235, 26237, 26390, 26271, 26385, 26273, 26074, 26098, 26149, 26167, 26187, 26226, 26234, 26175, 26053, 26196, 26074, 26312, 26134, 26107, 26172, 25958, 26218, 25969, 26005, 25955, 26053, 26125, 26254, 26139, 26058, 26206, 26187, 26380, 26226, 26029, 26271, 26302, 26209, 26380, 26161, 26283, 26122, 26049, 26426, 26027, 26076, 26173, 26012, 26183, 26372, 26175, 26423, 26262, 26224, 26064, 26041, 26348, 26237, 26188, 26242, 26391, 26037, 26003, 26440, 26160, 25922, 26373, 26136, 26185, 25835, 26321, 26172, 25946, 26111] Ovary-AdenoCA SBS3 T>G 20495.0 19758.0 20481.75 19893.76 0.5972687957414521 1.0 10.277 391686.0 Lagging 1.037 1.03 1.008 20495.0 20481.75 20272.0 20689.0 [20505, 20615, 20689, 20591, 20476, 20411, 20416, 20658, 20618, 20583, 20425, 20489, 20466, 20509, 20569, 20428, 20465, 20588, 20518, 20382, 20414, 20615, 20472, 20433, 20492, 20458, 20502, 20497, 20463, 20564, 20272, 20440, 20427, 20292, 20573, 20393, 20531, 20488, 20660, 20382, 20390, 20598, 20529, 20485, 20416, 20617, 20403, 20469, 20445, 20418, 20491, 20568, 20433, 20286, 20427, 20564, 20610, 20285, 20511, 20426, 20414, 20462, 20438, 20561, 20557, 20372, 20550, 20521, 20303, 20423, 20454, 20394, 20493, 20577, 20489, 20416, 20343, 20438, 20401, 20390, 20517, 20438, 20540, 20322, 20530, 20589, 20609, 20466, 20535, 20471, 20430, 20477, 20428, 20365, 20551, 20405, 20586, 20613, 20483, 20684] 19758.0 19893.76 19619.0 20128.0 [19924, 19834, 19700, 19737, 19917, 19953, 19918, 19796, 19731, 19793, 19918, 19973, 19930, 19967, 19800, 19943, 19953, 19623, 19799, 20013, 19964, 19844, 19910, 19932, 19880, 19889, 19902, 19905, 19893, 19807, 20047, 19958, 19964, 20021, 19941, 19915, 19840, 19935, 19729, 19874, 20060, 19906, 19836, 19757, 19942, 19728, 20073, 19969, 19938, 19917, 19927, 19998, 19942, 19956, 19919, 19780, 19806, 20128, 19845, 19939, 19933, 19968, 19926, 19737, 19817, 20057, 19789, 19901, 20108, 19918, 19924, 19915, 19913, 19823, 19886, 20053, 20049, 19944, 19858, 19896, 19840, 19847, 19884, 20022, 19837, 19749, 19858, 19910, 19883, 19950, 19881, 19886, 19953, 20025, 19813, 19942, 19859, 19704, 19761, 19619] Panc-AdenoCA SBS3 C>A 9943.0 10137.0 10000.26 10195.2 1.0 1.0 21.475 93504.0 Leading 1.02 1.019 1.0 9943.0 10000.26 9776.0 10176.0 [10100, 9894, 10055, 10150, 9875, 10093, 9964, 9948, 9976, 10007, 9945, 9947, 9874, 10035, 9949, 10026, 10079, 10003, 10014, 9971, 9998, 10034, 9920, 9845, 9959, 9898, 9980, 10065, 9959, 9977, 10057, 10021, 9888, 10080, 9989, 9971, 10086, 10020, 10113, 9872, 10122, 9938, 10066, 9977, 9961, 10010, 10141, 9816, 10036, 10146, 9934, 10008, 9960, 10062, 9948, 9964, 10176, 9899, 10017, 10127, 10016, 10094, 10033, 9922, 9926, 10006, 9938, 10076, 10020, 10070, 9853, 10065, 9999, 9929, 9926, 10077, 9980, 9922, 10000, 10100, 10013, 9955, 10028, 10016, 9976, 9898, 9922, 9976, 10052, 10107, 10123, 9910, 10104, 9776, 10031, 10098, 10036, 10140, 9916, 10052] 10137.0 10195.2 9975.0 10393.0 [10069, 10268, 10162, 10009, 10274, 10074, 10242, 10234, 10244, 10141, 10252, 10226, 10349, 10090, 10248, 10207, 10145, 10195, 10213, 10242, 10193, 10164, 10237, 10335, 10266, 10333, 10240, 10130, 10260, 10188, 10236, 10241, 10299, 10122, 10174, 10152, 10148, 10197, 10104, 10339, 10078, 10171, 10138, 10253, 10206, 10142, 10056, 10370, 10219, 10109, 10274, 10174, 10218, 10157, 10175, 10167, 9975, 10311, 10146, 10119, 10239, 10053, 10220, 10297, 10212, 10190, 10251, 10071, 10145, 10109, 10330, 10152, 10195, 10237, 10276, 10102, 10205, 10289, 10128, 10022, 10215, 10252, 10190, 10260, 10184, 10288, 10239, 10159, 10146, 10139, 10098, 10235, 10123, 10393, 10188, 10127, 10180, 10094, 10309, 10278] Panc-AdenoCA SBS3 C>G 12082.0 10674.0 11315.07 11461.77 3.1921456630846194e-13 2.2337113398463953e-12 24.337 93504.0 Lagging 1.132 0.987 1.147 1 12082.0 11315.07 11153.0 11462.0 [11345, 11320, 11348, 11253, 11245, 11230, 11263, 11285, 11247, 11393, 11281, 11261, 11351, 11294, 11376, 11214, 11447, 11322, 11364, 11186, 11168, 11184, 11454, 11321, 11461, 11282, 11245, 11321, 11413, 11385, 11358, 11278, 11284, 11332, 11211, 11335, 11372, 11417, 11254, 11266, 11216, 11397, 11318, 11391, 11392, 11402, 11343, 11326, 11358, 11360, 11401, 11293, 11334, 11224, 11280, 11330, 11256, 11316, 11462, 11291, 11262, 11427, 11250, 11182, 11333, 11296, 11319, 11393, 11264, 11428, 11263, 11332, 11238, 11277, 11278, 11272, 11303, 11291, 11366, 11307, 11153, 11370, 11349, 11236, 11339, 11184, 11450, 11424, 11301, 11321, 11255, 11371, 11302, 11291, 11388, 11323, 11371, 11319, 11323, 11300] 10674.0 11461.77 11321.0 11621.0 [11510, 11375, 11436, 11499, 11569, 11454, 11546, 11468, 11546, 11378, 11524, 11526, 11460, 11557, 11456, 11518, 11359, 11507, 11444, 11560, 11558, 11597, 11321, 11484, 11340, 11533, 11518, 11479, 11385, 11383, 11431, 11544, 11508, 11478, 11580, 11462, 11450, 11379, 11423, 11538, 11535, 11362, 11379, 11361, 11386, 11381, 11494, 11466, 11432, 11433, 11398, 11489, 11405, 11534, 11563, 11417, 11477, 11438, 11367, 11418, 11458, 11340, 11448, 11541, 11494, 11424, 11460, 11421, 11557, 11388, 11452, 11463, 11560, 11577, 11440, 11481, 11479, 11469, 11359, 11470, 11612, 11472, 11469, 11497, 11462, 11621, 11387, 11387, 11422, 11467, 11552, 11357, 11480, 11437, 11390, 11477, 11398, 11378, 11402, 11411] Panc-AdenoCA SBS3 C>T 2574.0 2439.0 2494.5 2523.14 0.10155795922566613 0.28865857575685433 5.361 93504.0 Lagging 1.055 0.989 1.067 2574.0 2494.5 2414.0 2569.0 [2497, 2501, 2517, 2500, 2547, 2520, 2494, 2487, 2547, 2484, 2529, 2484, 2509, 2532, 2485, 2505, 2526, 2473, 2483, 2414, 2566, 2544, 2536, 2487, 2500, 2561, 2480, 2476, 2566, 2451, 2490, 2427, 2516, 2429, 2467, 2507, 2515, 2483, 2475, 2490, 2504, 2464, 2496, 2506, 2510, 2495, 2522, 2470, 2460, 2525, 2464, 2479, 2468, 2507, 2483, 2498, 2543, 2483, 2445, 2478, 2513, 2499, 2440, 2462, 2445, 2500, 2505, 2500, 2499, 2428, 2492, 2519, 2467, 2454, 2449, 2482, 2498, 2465, 2498, 2486, 2548, 2549, 2468, 2504, 2472, 2459, 2481, 2461, 2514, 2569, 2490, 2490, 2503, 2509, 2507, 2560, 2490, 2482, 2450, 2543] 2439.0 2523.14 2439.0 2617.0 [2497, 2536, 2509, 2480, 2481, 2493, 2533, 2504, 2497, 2532, 2487, 2511, 2461, 2510, 2542, 2508, 2510, 2492, 2527, 2568, 2439, 2484, 2524, 2569, 2538, 2445, 2551, 2520, 2443, 2574, 2510, 2593, 2533, 2538, 2554, 2516, 2501, 2542, 2578, 2532, 2547, 2551, 2495, 2509, 2540, 2520, 2503, 2549, 2582, 2475, 2567, 2523, 2542, 2456, 2568, 2487, 2467, 2528, 2575, 2508, 2518, 2537, 2559, 2522, 2563, 2491, 2511, 2502, 2493, 2617, 2529, 2548, 2572, 2556, 2553, 2542, 2521, 2539, 2577, 2516, 2489, 2449, 2535, 2545, 2558, 2535, 2547, 2532, 2520, 2473, 2550, 2541, 2490, 2529, 2522, 2478, 2532, 2517, 2539, 2513] Panc-AdenoCA SBS3 T>A 15085.0 15151.0 15429.66 15117.28 0.12722855069804406 0.3478011251665689 32.337 93504.0 Leading 1.004 0.98 1.025 15085.0 15429.66 15175.0 15672.0 [15378, 15370, 15364, 15498, 15365, 15474, 15396, 15386, 15402, 15294, 15436, 15514, 15533, 15281, 15468, 15409, 15600, 15553, 15557, 15250, 15175, 15489, 15288, 15305, 15421, 15377, 15383, 15442, 15464, 15343, 15436, 15200, 15369, 15241, 15326, 15547, 15471, 15457, 15457, 15412, 15672, 15436, 15307, 15543, 15415, 15440, 15436, 15627, 15416, 15502, 15420, 15379, 15422, 15427, 15525, 15557, 15553, 15528, 15493, 15369, 15474, 15442, 15347, 15426, 15497, 15488, 15383, 15513, 15384, 15496, 15486, 15359, 15401, 15411, 15421, 15395, 15470, 15355, 15479, 15428, 15485, 15504, 15344, 15432, 15391, 15262, 15476, 15482, 15470, 15542, 15259, 15501, 15414, 15326, 15335, 15590, 15489, 15540, 15414, 15457] 15151.0 15117.28 14882.0 15336.0 [15247, 15174, 15150, 15068, 15259, 15106, 15186, 15215, 15189, 15213, 15081, 15098, 14989, 15227, 15120, 15163, 14936, 14952, 15057, 15336, 15310, 15029, 15306, 15250, 15163, 15138, 15154, 15028, 15105, 15165, 15063, 15252, 15206, 15269, 15196, 15040, 15089, 15083, 15135, 15149, 14947, 15087, 15215, 14956, 15084, 15149, 15085, 14942, 15165, 15019, 15040, 15218, 15117, 15040, 15042, 15019, 15008, 14995, 15084, 15120, 15056, 15060, 15108, 15106, 14993, 15003, 15167, 15079, 15081, 15075, 15118, 15220, 15200, 15097, 15162, 15100, 15052, 15224, 15080, 15089, 15137, 15067, 15145, 15087, 15111, 15224, 15057, 15119, 15134, 15077, 15297, 15040, 15185, 15205, 15193, 14882, 15119, 15049, 15166, 15136] Panc-AdenoCA SBS3 T>C 2684.0 2592.0 2665.29 2601.06 0.8000721156467784 1.0 5.643 93504.0 Lagging 1.035 1.025 1.011 2684.0 2665.29 2568.0 2743.0 [2626, 2674, 2700, 2677, 2651, 2684, 2677, 2638, 2658, 2727, 2630, 2614, 2729, 2733, 2673, 2651, 2705, 2644, 2724, 2695, 2634, 2680, 2638, 2681, 2740, 2665, 2624, 2662, 2659, 2662, 2686, 2595, 2644, 2611, 2602, 2568, 2675, 2670, 2652, 2694, 2584, 2596, 2668, 2690, 2658, 2708, 2626, 2659, 2743, 2706, 2607, 2720, 2644, 2661, 2616, 2580, 2633, 2691, 2663, 2723, 2687, 2714, 2673, 2659, 2659, 2657, 2662, 2626, 2663, 2700, 2721, 2668, 2689, 2666, 2605, 2659, 2622, 2620, 2692, 2697, 2646, 2663, 2710, 2740, 2705, 2614, 2668, 2684, 2712, 2652, 2743, 2670, 2681, 2720, 2677, 2606, 2627, 2694, 2620, 2630] 2592.0 2601.06 2519.0 2704.0 [2618, 2606, 2546, 2602, 2619, 2595, 2591, 2613, 2593, 2541, 2587, 2647, 2556, 2559, 2586, 2600, 2600, 2644, 2533, 2567, 2622, 2574, 2625, 2608, 2536, 2591, 2617, 2578, 2603, 2607, 2548, 2679, 2595, 2625, 2654, 2684, 2602, 2599, 2603, 2575, 2655, 2652, 2607, 2591, 2633, 2587, 2650, 2625, 2527, 2573, 2633, 2564, 2603, 2604, 2653, 2704, 2608, 2565, 2606, 2519, 2568, 2547, 2604, 2642, 2598, 2617, 2625, 2641, 2635, 2602, 2558, 2593, 2603, 2613, 2621, 2609, 2639, 2633, 2579, 2553, 2622, 2595, 2574, 2560, 2580, 2671, 2568, 2572, 2579, 2655, 2527, 2588, 2578, 2581, 2558, 2655, 2640, 2569, 2643, 2624] Panc-AdenoCA SBS3 T>G 5302.0 4841.0 5109.04 4988.92 0.017466377866354032 0.0604741226310254 10.848 93504.0 Lagging 1.095 1.024 1.069 5302.0 5109.04 4994.0 5273.0 [5108, 5087, 5077, 5106, 5116, 5128, 5132, 5064, 5036, 5095, 5273, 5059, 5118, 5165, 5114, 5137, 5201, 5067, 5183, 4998, 5051, 5139, 5099, 5140, 5113, 5094, 5100, 5080, 5065, 5038, 5210, 5135, 5059, 5130, 5088, 5116, 4994, 5144, 5067, 5084, 5071, 5119, 5145, 5000, 5109, 5049, 5098, 5124, 5190, 5081, 5042, 5114, 5165, 5113, 5114, 5068, 5070, 5098, 5026, 5144, 5106, 5155, 5177, 5155, 5036, 5082, 5037, 5063, 5085, 5089, 5190, 5022, 5066, 5085, 5051, 5149, 5104, 5111, 5097, 5097, 5135, 5092, 5166, 5152, 5108, 5197, 5248, 5039, 5063, 5136, 5121, 5174, 5197, 5119, 5221, 5055, 5167, 5162, 5192, 5053] 4841.0 4988.92 4807.0 5137.0 [5008, 4958, 5011, 5020, 5008, 5024, 4988, 5076, 5039, 5035, 4807, 5026, 4951, 4935, 4958, 4922, 4892, 5015, 4931, 5075, 4987, 4956, 5008, 5014, 4994, 5023, 5024, 4987, 5011, 5061, 4886, 5022, 4992, 4976, 5019, 4985, 5137, 4997, 4976, 5013, 5029, 4986, 4993, 5109, 4977, 5032, 5013, 4955, 4965, 5001, 5033, 4966, 4929, 4995, 4976, 5029, 4993, 4969, 5088, 4946, 5023, 4957, 4895, 4995, 5008, 5078, 5084, 5029, 4999, 5029, 4914, 5039, 4940, 5026, 5044, 4992, 5026, 4982, 5009, 5010, 4937, 4945, 4883, 4972, 4977, 4928, 4864, 5022, 5050, 4947, 4981, 4952, 4885, 4998, 4863, 4986, 4949, 4969, 4920, 5054] Panc-Endocrine SBS3 C>A 978.0 1120.0 1049.54 1077.19 0.07918604559795256 0.23401712900168983 26.153 8022.0 Leading 1.145 1.026 1.116 1 978.0 1049.54 988.0 1097.0 [1058, 1045, 1036, 1075, 1074, 1008, 1085, 1021, 1037, 1028, 1039, 1054, 1035, 1091, 1071, 1023, 1053, 1064, 1047, 1010, 1066, 1079, 1053, 1061, 1012, 1025, 1064, 1060, 1065, 1035, 1040, 1070, 1072, 1078, 1029, 1074, 1072, 1058, 1057, 1071, 1038, 1005, 1016, 1097, 1082, 1033, 1019, 1061, 1066, 1094, 1039, 1055, 1019, 1069, 1045, 1038, 1055, 1097, 1037, 1050, 1075, 1046, 1032, 1034, 1070, 1045, 1001, 1093, 1044, 1067, 1000, 1021, 1035, 1041, 1059, 1064, 1059, 988, 1007, 1013, 1042, 1082, 1067, 1020, 1035, 1038, 1050, 1049, 1055, 1068, 1084, 1079, 1058, 1069, 1086, 1020, 1026, 1012, 1071, 1039] 1120.0 1077.19 1021.0 1143.0 [1079, 1080, 1107, 1049, 1059, 1109, 1052, 1108, 1082, 1103, 1101, 1092, 1085, 1057, 1060, 1105, 1070, 1048, 1082, 1083, 1041, 1053, 1079, 1080, 1107, 1112, 1093, 1084, 1065, 1085, 1075, 1051, 1048, 1057, 1098, 1043, 1045, 1056, 1070, 1076, 1100, 1128, 1109, 1027, 1050, 1089, 1117, 1058, 1065, 1021, 1095, 1082, 1095, 1080, 1082, 1095, 1068, 1029, 1074, 1096, 1061, 1074, 1090, 1104, 1061, 1078, 1123, 1053, 1052, 1061, 1104, 1097, 1089, 1077, 1057, 1044, 1064, 1143, 1096, 1098, 1066, 1042, 1052, 1106, 1101, 1098, 1095, 1075, 1085, 1074, 1039, 1058, 1075, 1070, 1028, 1101, 1097, 1109, 1075, 1058] Panc-Endocrine SBS3 C>G 1022.0 1064.0 1036.21 1052.28 0.6874772776200238 1.0 26.003 8022.0 Leading 1.041 1.016 1.025 1022.0 1036.21 984.0 1093.0 [1073, 1043, 1000, 984, 1090, 989, 1019, 1051, 1020, 1014, 1093, 1062, 1045, 1023, 1039, 1048, 1087, 1014, 1002, 1005, 1022, 1017, 1052, 1051, 1005, 1049, 1020, 1001, 1023, 1042, 1043, 1055, 1030, 1040, 1028, 1030, 1034, 1033, 1066, 1046, 1060, 1000, 1040, 1051, 997, 1049, 1009, 1026, 1029, 1034, 1068, 1031, 1037, 1034, 1017, 1057, 1059, 1068, 1031, 1012, 1058, 1063, 1030, 1059, 1001, 1050, 1016, 1058, 1019, 1054, 1022, 998, 1050, 1027, 1051, 1068, 1065, 1073, 1039, 1012, 1057, 1026, 1026, 1035, 1059, 1058, 1011, 1035, 986, 1001, 1054, 1036, 1087, 1036, 1017, 1002, 1037, 1037, 1027, 1084] 1064.0 1052.28 991.0 1113.0 [1026, 1041, 1075, 1090, 1003, 1113, 1072, 1066, 1083, 1070, 991, 1013, 1054, 1057, 1047, 1062, 1011, 1066, 1090, 1075, 1045, 1057, 1031, 1043, 1095, 1037, 1067, 1077, 1062, 1065, 1050, 1059, 1046, 1040, 1055, 1059, 1069, 1056, 1029, 1039, 1049, 1083, 1063, 1023, 1059, 1025, 1066, 1070, 1077, 1048, 1045, 1062, 1054, 1063, 1056, 1023, 1028, 991, 1064, 1077, 1031, 1008, 1049, 1044, 1090, 1047, 1062, 1034, 1053, 1042, 1053, 1063, 1035, 1052, 1026, 1023, 1039, 1016, 1049, 1076, 1050, 1051, 1069, 1069, 1055, 1018, 1065, 1063, 1071, 1090, 1028, 1040, 1018, 1058, 1084, 1089, 1055, 1046, 1083, 1022] Panc-Endocrine SBS3 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 8022.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-Endocrine SBS3 T>A 1442.0 1468.0 1489.56 1451.94 0.4175830739385159 0.8371105271430942 36.275 8022.0 Leading 1.018 0.975 1.044 1442.0 1489.56 1415.0 1552.0 [1482, 1513, 1478, 1461, 1531, 1497, 1415, 1516, 1480, 1552, 1499, 1519, 1470, 1452, 1460, 1502, 1516, 1506, 1515, 1522, 1440, 1478, 1448, 1473, 1528, 1479, 1502, 1478, 1488, 1510, 1498, 1539, 1481, 1514, 1542, 1429, 1522, 1500, 1518, 1492, 1493, 1523, 1515, 1515, 1457, 1468, 1438, 1469, 1489, 1494, 1475, 1478, 1478, 1481, 1540, 1459, 1520, 1497, 1542, 1464, 1514, 1490, 1502, 1486, 1466, 1477, 1499, 1483, 1476, 1485, 1479, 1466, 1436, 1450, 1467, 1481, 1504, 1523, 1499, 1487, 1509, 1465, 1502, 1476, 1470, 1524, 1426, 1513, 1440, 1482, 1473, 1459, 1516, 1506, 1459, 1485, 1509, 1532, 1512, 1488] 1468.0 1451.94 1394.0 1517.0 [1463, 1403, 1473, 1462, 1394, 1444, 1512, 1427, 1436, 1401, 1432, 1397, 1473, 1459, 1487, 1442, 1421, 1414, 1427, 1416, 1496, 1473, 1511, 1473, 1437, 1466, 1437, 1455, 1462, 1449, 1454, 1421, 1437, 1445, 1402, 1504, 1411, 1437, 1422, 1422, 1456, 1445, 1457, 1442, 1461, 1436, 1492, 1461, 1479, 1443, 1492, 1465, 1479, 1478, 1399, 1482, 1431, 1436, 1434, 1487, 1432, 1456, 1441, 1480, 1494, 1479, 1449, 1448, 1472, 1452, 1445, 1463, 1504, 1476, 1454, 1454, 1422, 1431, 1450, 1459, 1428, 1471, 1427, 1454, 1465, 1417, 1517, 1430, 1515, 1458, 1486, 1480, 1417, 1451, 1481, 1447, 1434, 1439, 1397, 1467] Panc-Endocrine SBS3 T>C 137.0 110.0 126.14 123.45 0.2820168328825352 0.6388198493496754 3.079 8022.0 Lagging 1.245 1.022 1.219 1 1 137.0 126.14 110.0 147.0 [147, 134, 137, 126, 130, 123, 113, 132, 130, 112, 128, 128, 133, 130, 130, 134, 118, 120, 130, 123, 131, 117, 139, 127, 124, 117, 133, 132, 120, 123, 124, 123, 128, 110, 126, 123, 123, 112, 143, 116, 119, 118, 129, 121, 128, 115, 112, 126, 134, 132, 116, 136, 129, 127, 142, 117, 110, 136, 116, 126, 125, 129, 135, 132, 140, 122, 126, 138, 124, 122, 121, 128, 117, 127, 127, 116, 135, 111, 117, 133, 128, 133, 131, 124, 131, 128, 126, 130, 130, 125, 127, 133, 116, 114, 129, 135, 130, 123, 141, 117] 110.0 123.45 104.0 141.0 [104, 115, 111, 122, 123, 122, 139, 119, 119, 139, 129, 120, 120, 117, 118, 121, 131, 126, 113, 123, 118, 133, 118, 115, 123, 135, 118, 118, 126, 130, 121, 129, 123, 138, 124, 129, 127, 128, 108, 123, 131, 123, 126, 131, 119, 136, 139, 136, 119, 115, 137, 110, 121, 122, 112, 137, 128, 112, 134, 128, 123, 123, 114, 128, 115, 130, 118, 109, 114, 127, 124, 125, 132, 124, 122, 136, 121, 141, 127, 113, 121, 120, 119, 124, 114, 120, 115, 121, 122, 129, 128, 115, 134, 138, 119, 120, 121, 125, 112, 131] Panc-Endocrine SBS3 T>G 361.0 320.0 347.59 335.56 0.4480216947190055 0.8746058338261324 8.489 8022.0 Lagging 1.128 1.036 1.089 361.0 347.59 315.0 388.0 [335, 337, 376, 343, 324, 335, 356, 326, 332, 358, 367, 349, 357, 346, 365, 358, 367, 325, 329, 357, 370, 364, 335, 363, 361, 354, 352, 320, 342, 360, 330, 371, 362, 315, 333, 333, 351, 337, 329, 346, 388, 342, 350, 359, 348, 350, 347, 367, 358, 360, 344, 352, 338, 323, 372, 345, 326, 349, 349, 342, 337, 345, 341, 342, 350, 364, 379, 355, 332, 344, 354, 370, 335, 342, 357, 322, 348, 336, 364, 345, 365, 321, 343, 355, 349, 335, 347, 352, 353, 355, 325, 334, 365, 330, 359, 358, 359, 353, 329, 331] 320.0 335.56 300.0 367.0 [335, 351, 307, 343, 354, 346, 333, 352, 349, 334, 334, 330, 330, 330, 322, 314, 327, 358, 345, 334, 316, 324, 330, 311, 319, 336, 323, 367, 347, 329, 347, 334, 319, 363, 352, 349, 332, 356, 353, 344, 300, 343, 346, 325, 355, 334, 332, 318, 321, 332, 323, 321, 344, 350, 314, 342, 351, 342, 335, 336, 336, 320, 337, 344, 335, 323, 313, 327, 358, 326, 339, 311, 337, 335, 333, 365, 339, 346, 336, 336, 328, 346, 346, 307, 325, 353, 348, 319, 322, 338, 360, 350, 326, 362, 335, 324, 326, 329, 338, 335] Prost-AdenoCA SBS3 C>A 151.0 141.0 141.91 147.74 0.5610455331545705 0.9868288825182571 5.666 5154.0 Lagging 1.071 0.961 1.115 1 151.0 141.91 119.0 164.0 [148, 134, 133, 133, 131, 130, 131, 128, 139, 146, 137, 147, 141, 148, 141, 141, 150, 138, 138, 143, 136, 129, 140, 137, 149, 138, 135, 119, 130, 141, 143, 159, 151, 130, 145, 148, 144, 153, 150, 147, 147, 133, 146, 153, 157, 148, 143, 148, 164, 141, 139, 138, 151, 125, 144, 157, 134, 134, 136, 164, 144, 135, 137, 157, 131, 129, 153, 145, 134, 150, 130, 140, 128, 149, 134, 154, 144, 138, 147, 154, 136, 159, 136, 149, 159, 139, 135, 160, 132, 142, 134, 155, 154, 131, 143, 144, 139, 133, 131, 144] 141.0 147.74 125.0 166.0 [144, 156, 162, 153, 158, 162, 157, 159, 150, 143, 147, 146, 154, 141, 146, 143, 141, 155, 147, 147, 153, 156, 149, 158, 145, 153, 155, 166, 152, 152, 150, 133, 133, 163, 139, 145, 156, 143, 134, 144, 142, 156, 136, 136, 136, 139, 154, 135, 125, 150, 148, 147, 142, 158, 146, 137, 148, 157, 156, 126, 154, 153, 153, 134, 157, 154, 140, 144, 147, 141, 153, 150, 163, 146, 148, 137, 141, 149, 149, 130, 156, 130, 157, 136, 137, 155, 156, 126, 164, 153, 162, 142, 135, 160, 149, 138, 151, 154, 156, 150] Prost-AdenoCA SBS3 C>G 608.0 586.0 589.4 605.14 0.4613160918477826 0.8905591311875284 23.166 5154.0 Lagging 1.038 0.974 1.065 608.0 589.4 549.0 628.0 [605, 606, 567, 593, 571, 588, 590, 593, 600, 611, 587, 601, 578, 592, 609, 569, 593, 594, 591, 551, 579, 628, 594, 613, 578, 596, 615, 584, 592, 596, 596, 581, 553, 605, 578, 582, 607, 581, 585, 600, 597, 566, 583, 549, 608, 597, 582, 584, 559, 594, 581, 574, 590, 584, 599, 596, 589, 619, 560, 598, 572, 561, 584, 614, 590, 576, 584, 586, 624, 583, 577, 588, 576, 593, 590, 566, 577, 601, 580, 593, 558, 595, 606, 586, 605, 584, 586, 555, 600, 620, 595, 592, 583, 595, 620, 593, 588, 589, 618, 616] 586.0 605.14 574.0 645.0 [598, 605, 618, 575, 614, 602, 626, 611, 590, 591, 603, 586, 613, 588, 574, 622, 601, 600, 614, 625, 617, 578, 604, 582, 616, 601, 579, 595, 608, 606, 610, 622, 645, 601, 611, 617, 582, 613, 608, 595, 588, 628, 611, 632, 596, 609, 613, 619, 640, 597, 580, 628, 618, 599, 584, 598, 617, 597, 634, 590, 620, 618, 610, 585, 599, 623, 597, 620, 583, 595, 615, 607, 624, 607, 615, 627, 621, 593, 622, 606, 645, 604, 597, 606, 587, 599, 616, 625, 604, 579, 577, 609, 604, 587, 575, 585, 613, 618, 575, 598] Prost-AdenoCA SBS3 C>T 5.0 2.0 3.02 3.42 0.5920745920745922 1.0 0.136 5154.0 Lagging 2.5 0.883 2.831 1 1 1 1 1 1 5.0 3.02 0.0 6.0 [3, 5, 3, 4, 4, 4, 4, 3, 5, 2, 0, 2, 2, 1, 2, 2, 4, 6, 3, 3, 0, 3, 2, 4, 2, 2, 3, 3, 3, 3, 5, 3, 4, 3, 4, 2, 1, 3, 4, 4, 3, 4, 1, 4, 3, 4, 4, 2, 3, 5, 1, 2, 1, 4, 4, 3, 4, 5, 3, 2, 3, 1, 3, 2, 3, 5, 2, 3, 4, 4, 4, 4, 2, 3, 3, 5, 2, 2, 6, 4, 3, 5, 1, 3, 2, 3, 5, 2, 5, 2, 4, 3, 2, 0, 1, 1, 0, 4, 5, 4] 2.0 3.42 1.0 7.0 [4, 1, 4, 3, 3, 3, 2, 4, 2, 5, 6, 4, 4, 5, 5, 4, 3, 1, 4, 3, 7, 3, 5, 3, 5, 5, 3, 3, 4, 3, 2, 4, 2, 4, 2, 5, 5, 3, 1, 3, 4, 2, 5, 2, 4, 3, 2, 5, 4, 2, 3, 5, 3, 3, 3, 4, 1, 2, 3, 5, 3, 5, 3, 5, 4, 1, 4, 3, 3, 2, 2, 3, 4, 3, 4, 2, 4, 5, 1, 3, 3, 2, 6, 3, 5, 4, 2, 4, 2, 5, 3, 2, 5, 5, 4, 5, 6, 1, 2, 2] Prost-AdenoCA SBS3 T>A 1586.0 1769.0 1694.52 1670.97 0.011940895790162257 0.042569105149723556 65.095 5154.0 Leading 1.115 0.986 1.131 1 1586.0 1694.52 1603.0 1771.0 [1709, 1687, 1664, 1680, 1697, 1711, 1746, 1670, 1679, 1658, 1691, 1679, 1663, 1694, 1736, 1736, 1695, 1694, 1718, 1679, 1710, 1662, 1701, 1711, 1685, 1731, 1761, 1754, 1650, 1603, 1710, 1682, 1751, 1674, 1728, 1682, 1693, 1695, 1656, 1680, 1653, 1697, 1687, 1765, 1746, 1672, 1618, 1719, 1671, 1677, 1712, 1670, 1701, 1771, 1726, 1678, 1650, 1721, 1643, 1651, 1651, 1656, 1719, 1703, 1693, 1668, 1756, 1625, 1707, 1740, 1736, 1723, 1715, 1701, 1696, 1700, 1639, 1723, 1663, 1687, 1718, 1686, 1662, 1675, 1682, 1671, 1748, 1692, 1714, 1734, 1717, 1714, 1678, 1656, 1716, 1750, 1668, 1694, 1670, 1673] 1769.0 1670.97 1599.0 1769.0 [1666, 1694, 1697, 1687, 1674, 1668, 1638, 1714, 1674, 1703, 1665, 1673, 1664, 1633, 1660, 1670, 1674, 1696, 1646, 1693, 1675, 1693, 1645, 1620, 1713, 1634, 1599, 1637, 1710, 1769, 1687, 1671, 1622, 1694, 1668, 1677, 1676, 1647, 1685, 1675, 1717, 1659, 1673, 1602, 1633, 1686, 1721, 1662, 1703, 1677, 1644, 1719, 1674, 1607, 1636, 1673, 1719, 1660, 1727, 1733, 1693, 1703, 1642, 1660, 1673, 1692, 1612, 1733, 1656, 1630, 1617, 1649, 1657, 1647, 1668, 1660, 1739, 1634, 1703, 1671, 1669, 1659, 1678, 1693, 1679, 1724, 1624, 1679, 1653, 1651, 1627, 1625, 1699, 1707, 1653, 1617, 1668, 1668, 1681, 1693] Prost-AdenoCA SBS3 T>C 38.0 43.0 41.37 40.17 0.7533600159255996 1.0 1.572 5154.0 Leading 1.132 0.971 1.165 1 38.0 41.37 30.0 54.0 [30, 35, 40, 45, 47, 37, 38, 48, 41, 42, 34, 47, 42, 38, 35, 33, 40, 39, 42, 40, 43, 43, 42, 41, 38, 36, 38, 45, 41, 44, 40, 35, 39, 48, 47, 48, 46, 39, 44, 40, 42, 39, 36, 33, 45, 40, 43, 43, 46, 40, 37, 45, 47, 44, 43, 35, 54, 39, 50, 35, 42, 51, 41, 43, 34, 48, 46, 40, 43, 39, 42, 44, 46, 40, 43, 40, 34, 39, 37, 45, 45, 38, 45, 39, 39, 40, 47, 42, 43, 44, 36, 43, 41, 37, 40, 40, 38, 51, 45, 41] 43.0 40.17 26.0 51.0 [48, 49, 40, 37, 36, 48, 46, 31, 42, 39, 51, 34, 38, 43, 47, 51, 43, 40, 36, 40, 39, 40, 41, 38, 47, 43, 43, 32, 38, 35, 41, 42, 42, 31, 29, 33, 36, 46, 35, 42, 43, 41, 46, 48, 36, 43, 41, 41, 34, 38, 45, 38, 36, 34, 39, 48, 26, 44, 34, 44, 38, 34, 40, 38, 48, 34, 36, 45, 37, 40, 43, 40, 41, 42, 38, 41, 47, 41, 45, 36, 34, 44, 36, 42, 43, 46, 34, 39, 41, 37, 47, 38, 38, 45, 43, 38, 44, 30, 39, 44] Prost-AdenoCA SBS3 T>G 121.0 104.0 110.83 110.86 0.44856842116899776 0.8752195662346071 4.366 5154.0 Lagging 1.163 1.0 1.164 1 121.0 110.83 95.0 125.0 [117, 106, 123, 103, 111, 122, 104, 114, 110, 116, 112, 120, 110, 105, 108, 115, 114, 119, 106, 105, 111, 103, 106, 118, 107, 121, 114, 109, 95, 106, 122, 101, 118, 95, 103, 115, 117, 117, 104, 107, 106, 115, 125, 117, 112, 107, 116, 111, 114, 107, 116, 115, 103, 113, 125, 115, 114, 110, 115, 111, 117, 111, 119, 112, 107, 105, 112, 113, 115, 115, 100, 102, 113, 123, 103, 105, 105, 105, 108, 99, 112, 108, 106, 110, 108, 110, 101, 110, 112, 119, 105, 118, 119, 110, 102, 104, 110, 124, 105, 105] 104.0 110.86 92.0 129.0 [106, 118, 101, 121, 107, 100, 110, 116, 111, 107, 105, 113, 110, 116, 115, 104, 111, 106, 118, 117, 107, 125, 109, 104, 115, 101, 103, 108, 126, 113, 101, 121, 106, 129, 114, 107, 106, 109, 118, 114, 111, 113, 102, 102, 112, 117, 109, 105, 103, 124, 110, 104, 117, 111, 92, 112, 114, 111, 109, 102, 112, 109, 99, 108, 111, 113, 102, 107, 108, 106, 116, 118, 116, 99, 115, 110, 110, 114, 113, 123, 109, 117, 121, 112, 113, 116, 128, 108, 108, 100, 115, 98, 104, 119, 118, 120, 114, 107, 115, 107] Stomach-AdenoCA SBS3 C>A 12618.0 12961.0 12746.87 13059.41 0.8877286448842341 1.0 20.449 125086.0 Leading 1.027 1.025 1.003 12618.0 12746.87 12486.0 12908.0 [12741, 12642, 12569, 12628, 12776, 12689, 12748, 12791, 12847, 12731, 12800, 12735, 12879, 12717, 12845, 12875, 12647, 12891, 12718, 12772, 12620, 12719, 12740, 12796, 12842, 12755, 12757, 12765, 12651, 12835, 12646, 12672, 12689, 12845, 12809, 12750, 12633, 12795, 12788, 12848, 12706, 12742, 12821, 12822, 12783, 12728, 12711, 12633, 12809, 12734, 12789, 12814, 12611, 12686, 12850, 12791, 12486, 12763, 12718, 12851, 12795, 12748, 12908, 12810, 12701, 12697, 12607, 12718, 12829, 12786, 12901, 12724, 12724, 12796, 12704, 12813, 12740, 12676, 12707, 12576, 12597, 12852, 12775, 12709, 12749, 12806, 12701, 12729, 12764, 12609, 12705, 12778, 12769, 12727, 12829, 12852, 12820, 12834, 12727, 12551] 12961.0 13059.41 12890.0 13268.0 [13040, 13165, 13173, 13114, 12988, 13066, 13094, 13012, 12988, 13090, 13059, 13058, 12916, 12994, 12905, 12980, 13130, 12948, 13119, 13014, 13170, 13133, 13118, 13032, 12916, 13073, 12961, 13095, 13109, 13088, 13093, 13185, 13119, 12968, 12979, 13043, 13175, 13012, 13043, 13022, 13100, 13049, 13068, 12994, 13058, 13046, 13110, 13183, 13013, 13052, 13019, 12950, 13163, 13167, 13027, 12890, 13268, 13160, 13122, 12968, 13033, 13058, 12897, 13059, 13043, 13070, 13163, 13137, 12955, 13030, 12986, 13086, 13100, 12952, 13126, 13002, 13072, 13142, 13108, 13220, 13169, 12958, 12970, 13117, 13092, 13042, 12989, 13123, 13086, 13204, 13132, 13044, 12982, 13021, 12962, 12945, 13000, 12927, 13079, 13266] Stomach-AdenoCA SBS3 C>G 16826.0 14965.0 15779.57 16021.95 7.49360377210141e-17 5.832315167253308e-16 25.415 125086.0 Lagging 1.124 0.985 1.142 1 16826.0 15779.57 15479.0 15989.0 [15825, 15808, 15784, 15771, 15931, 15701, 15815, 15883, 15882, 15723, 15769, 15989, 15479, 15814, 15825, 15797, 15794, 15823, 15637, 15825, 15765, 15810, 15773, 15790, 15691, 15733, 15658, 15724, 15851, 15881, 15880, 15766, 15707, 15662, 15647, 15771, 15721, 15719, 15868, 15745, 15725, 15785, 15782, 15832, 15712, 15759, 15779, 15860, 15852, 15832, 15699, 15761, 15867, 15767, 15903, 15813, 15727, 15805, 15773, 15861, 15707, 15845, 15806, 15863, 15784, 15775, 15737, 15623, 15764, 15676, 15740, 15689, 15705, 15764, 15695, 15749, 15739, 15739, 15745, 15836, 15861, 15865, 15766, 15768, 15801, 15779, 15781, 15817, 15627, 15703, 15746, 15910, 15792, 15923, 15910, 15838, 15783, 15739, 15743, 15893] 14965.0 16021.95 15773.0 16243.0 [15908, 15904, 16025, 15933, 15928, 16072, 16017, 15960, 15873, 16026, 16087, 15817, 16243, 16015, 15932, 16005, 16009, 16025, 16053, 15990, 16034, 15892, 15971, 15951, 16028, 16065, 16196, 16055, 15972, 15928, 15969, 15983, 16145, 16088, 16180, 16082, 16076, 16110, 15921, 16079, 16023, 16032, 16075, 16023, 16116, 16034, 16049, 16023, 15926, 15954, 16125, 16011, 15951, 16045, 15824, 15988, 15975, 15987, 16140, 16005, 16153, 15966, 15899, 15976, 15974, 16095, 16104, 16108, 16059, 16086, 16158, 16142, 16108, 16015, 16095, 16129, 16096, 16061, 16015, 15949, 15967, 15985, 16041, 16031, 16033, 16042, 15961, 16072, 16181, 16060, 16007, 15849, 16086, 15906, 15941, 16028, 16020, 16082, 16089, 15773] Stomach-AdenoCA SBS3 C>T 5286.0 5008.0 5134.45 5219.37 0.01175337665341284 0.04201546728670009 8.23 125086.0 Lagging 1.056 0.984 1.073 5286.0 5134.45 5004.0 5260.0 [5107, 5121, 5095, 5082, 5111, 5120, 5062, 5222, 5260, 5109, 5187, 5170, 5188, 5107, 5070, 5153, 5129, 5141, 5004, 5069, 5082, 5154, 5102, 5177, 5162, 5018, 5111, 5140, 5152, 5151, 5036, 5190, 5182, 5108, 5044, 5200, 5152, 5093, 5160, 5194, 5209, 5108, 5130, 5153, 5119, 5230, 5193, 5133, 5214, 5164, 5122, 5091, 5132, 5225, 5185, 5200, 5186, 5181, 5151, 5092, 5068, 5027, 5119, 5157, 5167, 5140, 5164, 5178, 5111, 5137, 5115, 5155, 5150, 5102, 5103, 5135, 5040, 5073, 5176, 5137, 5116, 5118, 5098, 5151, 5120, 5107, 5116, 5097, 5102, 5127, 5248, 5140, 5134, 5024, 5221, 5134, 5035, 5164, 5203, 5203] 5008.0 5219.37 5070.0 5357.0 [5276, 5223, 5282, 5226, 5254, 5231, 5315, 5183, 5070, 5215, 5164, 5185, 5180, 5271, 5305, 5204, 5263, 5181, 5357, 5266, 5265, 5197, 5206, 5214, 5182, 5318, 5189, 5168, 5173, 5183, 5327, 5197, 5179, 5250, 5264, 5216, 5214, 5237, 5163, 5222, 5122, 5211, 5231, 5221, 5227, 5138, 5206, 5220, 5162, 5253, 5238, 5258, 5218, 5133, 5163, 5144, 5196, 5193, 5179, 5198, 5294, 5337, 5219, 5184, 5193, 5246, 5170, 5190, 5219, 5208, 5257, 5211, 5211, 5218, 5264, 5204, 5313, 5269, 5246, 5251, 5196, 5213, 5242, 5248, 5227, 5217, 5188, 5239, 5268, 5221, 5106, 5218, 5215, 5298, 5116, 5242, 5310, 5206, 5148, 5189] Stomach-AdenoCA SBS3 T>A 15640.0 15723.0 16004.08 15632.71 0.0717240522695499 0.21511505167149242 25.073 125086.0 Leading 1.005 0.977 1.029 15640.0 16004.08 15810.0 16242.0 [16092, 16060, 16009, 15974, 16041, 16112, 15933, 15980, 16046, 15983, 15925, 15972, 16002, 15949, 15978, 15988, 15984, 16163, 16026, 15868, 15920, 15914, 16062, 15887, 16048, 16102, 16178, 16142, 15840, 16028, 15945, 15997, 16106, 16123, 16145, 16014, 15920, 15909, 15961, 16139, 16036, 16177, 15906, 15920, 15987, 16028, 16044, 16023, 16036, 15876, 15987, 15973, 16139, 16117, 15931, 15948, 15913, 15894, 15976, 16080, 15812, 15893, 15999, 15884, 15921, 16039, 15936, 16109, 16001, 16067, 16091, 15946, 15961, 16103, 16049, 15992, 16036, 16036, 15971, 15893, 16019, 16059, 16242, 16080, 16038, 16022, 15874, 15810, 16105, 15889, 16052, 15924, 16059, 16116, 15874, 15984, 15977, 16116, 15903, 16070] 15723.0 15632.71 15347.0 15846.0 [15546, 15559, 15623, 15606, 15614, 15542, 15622, 15651, 15571, 15684, 15660, 15650, 15657, 15627, 15585, 15637, 15687, 15491, 15593, 15758, 15767, 15788, 15589, 15667, 15679, 15448, 15495, 15572, 15808, 15612, 15636, 15575, 15605, 15538, 15482, 15601, 15669, 15613, 15788, 15534, 15642, 15494, 15722, 15735, 15694, 15645, 15551, 15610, 15556, 15800, 15691, 15626, 15465, 15474, 15717, 15741, 15731, 15717, 15661, 15495, 15732, 15772, 15721, 15729, 15706, 15605, 15627, 15617, 15626, 15591, 15609, 15733, 15638, 15551, 15557, 15635, 15551, 15560, 15637, 15672, 15690, 15613, 15347, 15574, 15592, 15680, 15704, 15846, 15572, 15817, 15569, 15696, 15607, 15568, 15818, 15627, 15643, 15512, 15721, 15610] Stomach-AdenoCA SBS3 T>C 5873.0 5697.0 5822.4 5702.73 0.7223152920434402 1.0 9.25 125086.0 Lagging 1.031 1.021 1.01 5873.0 5822.4 5697.0 5974.0 [5697, 5805, 5749, 5831, 5792, 5786, 5845, 5739, 5761, 5892, 5774, 5858, 5797, 5855, 5800, 5793, 5889, 5845, 5783, 5792, 5830, 5910, 5797, 5896, 5792, 5861, 5860, 5750, 5770, 5974, 5746, 5872, 5783, 5865, 5812, 5865, 5867, 5763, 5748, 5847, 5761, 5824, 5849, 5750, 5810, 5833, 5899, 5810, 5820, 5794, 5849, 5823, 5845, 5774, 5907, 5811, 5844, 5793, 5885, 5795, 5871, 5768, 5738, 5884, 5944, 5879, 5897, 5796, 5852, 5762, 5829, 5734, 5850, 5814, 5891, 5810, 5800, 5839, 5817, 5781, 5886, 5860, 5823, 5898, 5801, 5822, 5732, 5816, 5881, 5767, 5848, 5780, 5890, 5804, 5860, 5770, 5810, 5857, 5801, 5811] 5697.0 5702.73 5549.0 5813.0 [5775, 5739, 5813, 5680, 5705, 5744, 5723, 5733, 5721, 5614, 5686, 5695, 5721, 5655, 5715, 5737, 5631, 5684, 5765, 5711, 5670, 5682, 5702, 5652, 5727, 5724, 5667, 5776, 5765, 5549, 5762, 5718, 5705, 5672, 5729, 5679, 5664, 5744, 5761, 5647, 5763, 5710, 5699, 5768, 5733, 5733, 5647, 5696, 5729, 5744, 5657, 5706, 5701, 5776, 5623, 5680, 5713, 5777, 5577, 5710, 5654, 5794, 5797, 5681, 5612, 5617, 5637, 5713, 5690, 5803, 5626, 5782, 5676, 5712, 5623, 5709, 5715, 5743, 5718, 5754, 5660, 5696, 5701, 5626, 5637, 5722, 5810, 5703, 5639, 5738, 5706, 5759, 5612, 5660, 5657, 5681, 5745, 5658, 5701, 5722] Stomach-AdenoCA SBS3 T>G 7265.0 7224.0 7374.48 7204.16 0.4527956162186934 0.8799730453804736 11.583 125086.0 Lagging 1.006 1.024 0.982 7265.0 7374.48 7211.0 7518.0 [7301, 7423, 7324, 7458, 7432, 7325, 7347, 7435, 7416, 7432, 7352, 7397, 7402, 7402, 7441, 7430, 7337, 7408, 7345, 7346, 7291, 7452, 7211, 7403, 7373, 7279, 7319, 7372, 7488, 7484, 7387, 7377, 7317, 7311, 7476, 7479, 7372, 7391, 7354, 7357, 7369, 7308, 7424, 7336, 7355, 7318, 7481, 7454, 7262, 7466, 7373, 7419, 7470, 7255, 7332, 7480, 7383, 7382, 7411, 7375, 7288, 7262, 7418, 7332, 7386, 7465, 7375, 7308, 7407, 7397, 7405, 7381, 7386, 7432, 7307, 7395, 7278, 7440, 7312, 7404, 7360, 7395, 7339, 7322, 7349, 7326, 7454, 7433, 7334, 7518, 7247, 7292, 7412, 7336, 7316, 7401, 7283, 7358, 7268, 7428] 7224.0 7204.16 7056.0 7371.0 [7279, 7175, 7244, 7136, 7159, 7272, 7247, 7187, 7135, 7207, 7234, 7178, 7199, 7218, 7217, 7204, 7214, 7139, 7291, 7277, 7275, 7115, 7335, 7132, 7201, 7271, 7286, 7206, 7176, 7090, 7115, 7249, 7198, 7312, 7082, 7155, 7211, 7212, 7246, 7169, 7202, 7231, 7200, 7247, 7218, 7192, 7113, 7155, 7280, 7136, 7194, 7139, 7110, 7317, 7241, 7067, 7223, 7150, 7056, 7182, 7239, 7335, 7227, 7232, 7143, 7174, 7202, 7218, 7153, 7159, 7166, 7212, 7149, 7140, 7229, 7162, 7245, 7131, 7276, 7226, 7316, 7206, 7188, 7230, 7224, 7256, 7067, 7119, 7202, 7086, 7371, 7319, 7192, 7314, 7330, 7149, 7243, 7243, 7306, 7136] Uterus-AdenoCA SBS3 C>A 968.0 884.0 915.84 935.67 0.09359419938666357 0.26954843202565876 19.89 9311.0 Lagging 1.095 0.979 1.119 1 968.0 915.84 867.0 960.0 [913, 911, 872, 913, 918, 930, 925, 910, 937, 919, 868, 916, 943, 906, 941, 893, 919, 916, 890, 924, 917, 927, 955, 909, 960, 886, 922, 909, 929, 943, 902, 914, 875, 953, 949, 914, 925, 897, 938, 888, 938, 896, 897, 950, 927, 955, 914, 893, 890, 890, 912, 894, 917, 898, 903, 931, 910, 888, 898, 867, 930, 932, 909, 893, 909, 928, 872, 909, 891, 914, 918, 893, 921, 924, 913, 904, 939, 937, 939, 916, 958, 915, 926, 883, 938, 924, 924, 916, 934, 915, 917, 886, 923, 927, 910, 921, 906, 952, 938, 936] 884.0 935.67 892.0 1001.0 [959, 923, 970, 923, 942, 932, 935, 948, 918, 946, 961, 925, 923, 916, 907, 946, 950, 912, 971, 933, 935, 931, 921, 964, 899, 973, 924, 938, 926, 911, 943, 930, 955, 905, 933, 968, 944, 977, 904, 947, 906, 959, 987, 900, 940, 905, 951, 954, 961, 967, 940, 949, 925, 952, 940, 914, 944, 972, 928, 952, 921, 918, 934, 954, 952, 923, 1001, 935, 955, 937, 936, 960, 911, 930, 937, 953, 922, 895, 897, 946, 905, 920, 933, 945, 907, 932, 903, 942, 902, 944, 914, 963, 924, 930, 943, 952, 961, 892, 921, 903] Uterus-AdenoCA SBS3 C>G 758.0 736.0 746.65 745.96 0.7143630713119499 1.0 16.046 9311.0 Lagging 1.03 1.001 1.029 758.0 746.65 687.0 796.0 [773, 742, 714, 773, 755, 764, 768, 725, 770, 720, 776, 770, 731, 762, 748, 734, 749, 748, 729, 778, 760, 750, 708, 747, 697, 722, 719, 766, 724, 741, 739, 736, 771, 741, 796, 768, 729, 732, 756, 743, 718, 760, 763, 762, 754, 743, 770, 753, 748, 768, 706, 750, 745, 756, 771, 737, 745, 767, 778, 753, 752, 775, 708, 718, 758, 737, 750, 776, 747, 716, 770, 790, 737, 733, 726, 733, 753, 733, 782, 769, 748, 739, 753, 739, 732, 736, 732, 765, 751, 752, 750, 761, 738, 730, 754, 732, 715, 720, 687, 747] 736.0 745.96 691.0 801.0 [701, 751, 789, 738, 744, 739, 730, 760, 699, 777, 727, 726, 767, 752, 747, 749, 742, 743, 760, 718, 708, 729, 791, 757, 777, 785, 783, 720, 782, 739, 724, 763, 736, 762, 691, 734, 766, 751, 743, 737, 772, 723, 724, 740, 738, 758, 732, 753, 753, 750, 795, 725, 748, 742, 738, 746, 756, 724, 723, 744, 744, 716, 787, 770, 729, 750, 734, 739, 752, 782, 720, 703, 761, 763, 767, 765, 748, 761, 712, 726, 735, 737, 734, 737, 754, 758, 758, 713, 737, 722, 747, 756, 746, 756, 733, 757, 782, 739, 801, 744] Uterus-AdenoCA SBS3 C>T 611.0 598.0 591.83 602.59 0.6535155301958679 1.0 12.985 9311.0 Lagging 1.022 0.982 1.04 611.0 591.83 546.0 640.0 [606, 572, 578, 599, 584, 585, 603, 599, 587, 585, 587, 608, 608, 567, 594, 600, 597, 576, 612, 610, 572, 613, 605, 570, 595, 594, 575, 614, 592, 586, 598, 598, 587, 596, 612, 591, 623, 601, 555, 574, 625, 598, 568, 574, 593, 581, 607, 571, 569, 604, 546, 606, 574, 610, 567, 569, 593, 589, 594, 614, 640, 609, 620, 579, 576, 588, 556, 583, 595, 588, 590, 572, 609, 611, 594, 585, 576, 593, 597, 582, 616, 601, 576, 614, 604, 570, 566, 590, 587, 576, 617, 589, 573, 618, 585, 593, 602, 633, 584, 586] 598.0 602.59 553.0 649.0 [606, 604, 614, 586, 603, 609, 584, 590, 591, 602, 594, 608, 582, 623, 594, 592, 600, 616, 577, 578, 617, 587, 587, 620, 593, 614, 625, 591, 606, 620, 600, 593, 605, 609, 595, 604, 579, 589, 635, 619, 575, 609, 620, 615, 602, 634, 595, 602, 630, 606, 649, 600, 612, 589, 621, 628, 595, 599, 603, 578, 553, 581, 586, 610, 624, 583, 635, 601, 605, 616, 592, 621, 602, 591, 598, 616, 612, 604, 619, 609, 593, 587, 607, 595, 601, 614, 631, 622, 603, 606, 570, 598, 621, 577, 605, 596, 585, 570, 607, 610] Uterus-AdenoCA SBS3 T>A 711.0 752.0 746.64 731.05 0.3019636970049436 0.6716181341965888 15.713 9311.0 Leading 1.058 0.979 1.08 711.0 746.64 700.0 796.0 [733, 721, 780, 740, 726, 779, 767, 772, 748, 738, 780, 751, 737, 740, 750, 731, 725, 755, 731, 713, 720, 756, 790, 745, 760, 719, 728, 735, 763, 738, 740, 758, 776, 740, 795, 727, 722, 722, 762, 760, 715, 731, 752, 761, 728, 750, 749, 737, 767, 763, 722, 738, 739, 775, 736, 707, 741, 740, 743, 767, 753, 796, 765, 792, 763, 747, 740, 779, 728, 743, 763, 700, 733, 761, 752, 796, 765, 733, 737, 738, 752, 770, 774, 760, 746, 739, 747, 749, 739, 726, 720, 735, 752, 722, 738, 751, 756, 715, 725, 730] 752.0 731.05 671.0 772.0 [763, 754, 687, 740, 730, 723, 716, 722, 724, 747, 694, 733, 725, 737, 736, 748, 749, 726, 736, 746, 768, 734, 689, 738, 710, 752, 771, 726, 719, 731, 732, 724, 712, 751, 671, 745, 748, 772, 713, 712, 755, 749, 741, 729, 740, 708, 712, 748, 693, 723, 759, 748, 744, 710, 767, 751, 716, 720, 744, 713, 728, 688, 726, 700, 732, 726, 733, 692, 758, 731, 697, 768, 741, 711, 724, 682, 717, 731, 745, 722, 736, 711, 707, 706, 752, 731, 745, 736, 749, 737, 750, 733, 737, 752, 740, 727, 733, 758, 743, 746] Uterus-AdenoCA SBS3 T>C 1003.0 1034.0 1030.61 1014.47 0.4715343643917881 0.9010718457946403 21.877 9311.0 Leading 1.031 0.984 1.047 1003.0 1030.61 972.0 1072.0 [1007, 997, 1051, 1040, 1057, 1059, 1041, 1033, 1027, 1050, 1041, 1016, 1011, 1038, 999, 1044, 972, 1049, 1012, 1035, 1041, 1061, 1028, 999, 1062, 1014, 1008, 1026, 1019, 1053, 987, 1017, 1023, 1009, 1014, 1053, 1020, 1031, 1054, 1040, 1059, 1048, 1026, 1016, 1060, 1039, 1006, 1031, 1045, 1028, 1041, 1028, 1048, 1065, 1020, 986, 984, 1058, 1039, 1058, 1033, 1032, 994, 1036, 1020, 1049, 1052, 1034, 1013, 1012, 1019, 1051, 1031, 981, 1037, 1034, 998, 1050, 1015, 1041, 1015, 1034, 1011, 1047, 1029, 1041, 1048, 1012, 1011, 1015, 1007, 1043, 1072, 1061, 1044, 1035, 1072, 1036, 1033, 1040] 1034.0 1014.47 975.0 1066.0 [1045, 1062, 1009, 1017, 979, 993, 1017, 1028, 1032, 990, 1011, 1029, 1066, 1003, 1046, 1004, 1042, 1004, 1034, 1039, 1010, 997, 1030, 1021, 995, 1033, 1041, 1015, 1020, 999, 1036, 1028, 1020, 1037, 1035, 998, 1026, 1012, 984, 1012, 993, 1015, 1050, 1037, 989, 1004, 1039, 1002, 988, 1021, 976, 1022, 1008, 989, 1015, 1052, 1051, 979, 1011, 1002, 985, 1007, 1044, 1005, 1012, 1000, 981, 1030, 1027, 1020, 1005, 1001, 1020, 1044, 998, 1002, 1043, 994, 1026, 1005, 1022, 1008, 1020, 992, 1001, 1015, 995, 1032, 1026, 1019, 1033, 981, 976, 1000, 995, 1001, 975, 1018, 1018, 1029] Uterus-AdenoCA SBS3 T>G 649.0 607.0 640.65 621.44 0.6609788204693767 1.0 13.489 9311.0 Lagging 1.069 1.031 1.037 649.0 640.65 596.0 688.0 [638, 654, 643, 625, 661, 639, 641, 655, 621, 671, 609, 625, 626, 662, 667, 625, 637, 663, 625, 632, 634, 629, 653, 629, 661, 643, 633, 645, 643, 635, 642, 644, 632, 629, 629, 645, 647, 646, 634, 625, 627, 653, 624, 663, 648, 645, 650, 644, 646, 596, 618, 626, 626, 664, 613, 638, 660, 637, 639, 632, 616, 651, 647, 639, 661, 620, 631, 640, 675, 617, 651, 613, 625, 650, 643, 688, 624, 647, 624, 649, 648, 632, 631, 634, 619, 642, 665, 666, 628, 644, 658, 660, 637, 650, 650, 649, 661, 636, 648, 650] 607.0 621.44 588.0 658.0 [619, 611, 611, 638, 600, 630, 639, 616, 631, 604, 653, 628, 634, 601, 606, 619, 625, 592, 615, 614, 621, 646, 606, 638, 602, 622, 638, 612, 625, 627, 625, 626, 642, 642, 629, 603, 616, 615, 617, 632, 634, 599, 632, 612, 591, 632, 616, 619, 638, 647, 632, 636, 624, 603, 643, 631, 603, 637, 617, 624, 658, 604, 619, 628, 611, 634, 632, 624, 588, 632, 619, 652, 622, 602, 623, 589, 638, 614, 646, 631, 595, 625, 641, 620, 653, 612, 621, 625, 632, 598, 598, 596, 615, 618, 599, 612, 609, 635, 600, 634] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS3 C>G Lagging ['Breast-Cancer', 'ESCC', 'Eso-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Stomach-AdenoCA'] 6 [] 0 [] 0 [] 0 [] 0 [] 0 ['Bone-Osteosarc', 'Breast-Cancer', 'CNS-Medullo', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Panc-Endocrine', 'Prost-AdenoCA', 'Stomach-AdenoCA', 'Uterus-AdenoCA'] 14 1.0999999999999999 SBS3 C>T Lagging ['Breast-Cancer'] 1 [] 0 [] 0 [] 0 [] 0 [] 0 ['Bone-Osteosarc', 'Breast-Cancer', 'CNS-Medullo', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Panc-Endocrine', 'Prost-AdenoCA', 'Stomach-AdenoCA', 'Uterus-AdenoCA'] 14 1.1 SBS3 T>A Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Bone-Osteosarc', 'Breast-Cancer', 'CNS-Medullo', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Panc-Endocrine', 'Prost-AdenoCA', 'Stomach-AdenoCA', 'Uterus-AdenoCA'] 14 SBS3 T>A Leading ['Prost-AdenoCA'] 1 [] 0 [] 0 [] 0 [] 0 [] 0 ['Bone-Osteosarc', 'Breast-Cancer', 'CNS-Medullo', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Panc-Endocrine', 'Prost-AdenoCA', 'Stomach-AdenoCA', 'Uterus-AdenoCA'] 14 1.1 SBS3 T>C Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Bone-Osteosarc', 'Breast-Cancer', 'CNS-Medullo', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Panc-Endocrine', 'Prost-AdenoCA', 'Stomach-AdenoCA', 'Uterus-AdenoCA'] 14 SBS3 T>G Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Bone-Osteosarc', 'Breast-Cancer', 'CNS-Medullo', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Panc-Endocrine', 'Prost-AdenoCA', 'Stomach-AdenoCA', 'Uterus-AdenoCA'] 14