# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 368.759 E:A[C>A]A 398.146 A:A[C>G]A 1236.024 E:A[C>G]A 1165.378 A:A[C>T]A 265.624 E:A[C>T]A 258.504 A:A[T>A]A 179.401 E:A[T>A]A 176.855 A:A[T>C]A 244.739 E:A[T>C]A 241.838 A:A[T>G]A 220.375 E:A[T>G]A 214.049 A:A[C>A]C 290.953 E:A[C>A]C 284.267 A:A[C>G]C 617.652 E:A[C>G]C 618.809 A:A[C>T]C 107.287 E:A[C>T]C 106.183 A:A[T>A]C 93.126 E:A[T>A]C 100.12 A:A[T>C]C 179.528 E:A[T>C]C 185.236 A:A[T>G]C 109.117 E:A[T>G]C 108.219 A:A[C>A]G 99.582 E:A[C>A]G 94.782 A:A[C>G]G 361.653 E:A[C>G]G 402.692 A:A[C>T]G 204.546 E:A[C>T]G 202.046 A:A[T>A]G 221.615 E:A[T>A]G 223.407 A:A[T>C]G 182.047 E:A[T>C]G 188.062 A:A[T>G]G 257.223 E:A[T>G]G 263.385 A:A[C>A]T 325.945 E:A[C>A]T 342.301 A:A[C>G]T 1201.814 E:A[C>G]T 1117.999 A:A[C>T]T 382.158 E:A[C>T]T 383.103 A:A[T>A]T 220.003 E:A[T>A]T 217.652 A:A[T>C]T 324.032 E:A[T>C]T 323.574 A:A[T>G]T 311.774 E:A[T>G]T 280.736 A:C[C>A]A 411.827 E:C[C>A]A 412.046 A:C[C>G]A 736.231 E:C[C>G]A 722.837 A:C[C>T]A 262.537 E:C[C>T]A 235.258 A:C[T>A]A 245.265 E:C[T>A]A 248.844 A:C[T>C]A 201.266 E:C[T>C]A 202.411 A:C[T>G]A 222.853 E:C[T>G]A 218.994 A:C[C>A]C 387.765 E:C[C>A]C 399.419 A:C[C>G]C 611.053 E:C[C>G]C 634.96 A:C[C>T]C 99.9 E:C[C>T]C 105.831 A:C[T>A]C 262.148 E:C[T>A]C 267.65 A:C[T>C]C 312.065 E:C[T>C]C 316.258 A:C[T>G]C 201.259 E:C[T>G]C 203.912 A:C[C>A]G 122.811 E:C[C>A]G 115.641 A:C[C>G]G 313.568 E:C[C>G]G 291.85 A:C[C>T]G 156.066 E:C[C>T]G 156.173 A:C[T>A]G 299.377 E:C[T>A]G 293.085 A:C[T>C]G 172.753 E:C[T>C]G 170.26 A:C[T>G]G 334.835 E:C[T>G]G 318.661 A:C[C>A]T 325.949 E:C[C>A]T 327.762 A:C[C>G]T 1074.191 E:C[C>G]T 930.089 A:C[C>T]T 242.495 E:C[C>T]T 230.662 A:C[T>A]T 497.521 E:C[T>A]T 491.834 A:C[T>C]T 312.116 E:C[T>C]T 289.866 A:C[T>G]T 247.172 E:C[T>G]T 233.577 A:G[C>A]A 189.67 E:G[C>A]A 195.09 A:G[C>G]A 503.278 E:G[C>G]A 494.664 A:G[C>T]A 231.016 E:G[C>T]A 225.008 A:G[T>A]A 166.323 E:G[T>A]A 167.784 A:G[T>C]A 215.938 E:G[T>C]A 211.97 A:G[T>G]A 142.448 E:G[T>G]A 138.752 A:G[C>A]C 209.193 E:G[C>A]C 201.534 A:G[C>G]C 457.239 E:G[C>G]C 446.025 A:G[C>T]C 108.903 E:G[C>T]C 106.011 A:G[T>A]C 121.398 E:G[T>A]C 118.441 A:G[T>C]C 214.669 E:G[T>C]C 206.793 A:G[T>G]C 142.518 E:G[T>G]C 132.402 A:G[C>A]G 68.923 E:G[C>A]G 66.742 A:G[C>G]G 150.486 E:G[C>G]G 164.618 A:G[C>T]G 140.996 E:G[C>T]G 133.444 A:G[T>A]G 198.735 E:G[T>A]G 196.972 A:G[T>C]G 140.83 E:G[T>C]G 131.534 A:G[T>G]G 204.271 E:G[T>G]G 184.692 A:G[C>A]T 202.37 E:G[C>A]T 197.497 A:G[C>G]T 848.555 E:G[C>G]T 725.497 A:G[C>T]T 241.742 E:G[C>T]T 218.64 A:G[T>A]T 214.87 E:G[T>A]T 211.6 A:G[T>C]T 241.411 E:G[T>C]T 239.38 A:G[T>G]T 302.089 E:G[T>G]T 290.614 A:T[C>A]A 179.119 E:T[C>A]A 181.688 A:T[C>G]A 1034.591 E:T[C>G]A 952.594 A:T[C>T]A 125.284 E:T[C>T]A 117.072 A:T[T>A]A 202.687 E:T[T>A]A 198.137 A:T[T>C]A 143.82 E:T[T>C]A 142.087 A:T[T>G]A 257.051 E:T[T>G]A 238.395 A:T[C>A]C 262.526 E:T[C>A]C 269.109 A:T[C>G]C 1047.86 E:T[C>G]C 973.063 A:T[C>T]C 160.654 E:T[C>T]C 151.761 A:T[T>A]C 134.584 E:T[T>A]C 131.313 A:T[T>C]C 222.813 E:T[T>C]C 224.891 A:T[T>G]C 137.421 E:T[T>G]C 138.846 A:T[C>A]G 50.918 E:T[C>A]G 51.922 A:T[C>G]G 223.353 E:T[C>G]G 208.031 A:T[C>T]G 104.427 E:T[C>T]G 98.224 A:T[T>A]G 175.22 E:T[T>A]G 161.436 A:T[T>C]G 112.271 E:T[T>C]G 100.176 A:T[T>G]G 289.715 E:T[T>G]G 275.218 A:T[C>A]T 237.33 E:T[C>A]T 220.736 A:T[C>G]T 1853.42 E:T[C>G]T 1530.435 A:T[C>T]T 148.288 E:T[C>T]T 134.007 A:T[T>A]T 395.423 E:T[T>A]T 371.779 A:T[T>C]T 261.482 E:T[T>C]T 243.705 A:T[T>G]T 359.083 E:T[T>G]T 320.996 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Breast-Cancer SBS39 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 11272.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS39 C>G 5912.0 5188.0 5484.26 5572.18 5.1978640548634095e-08 2.944414119499318e-07 98.474 11272.0 Lagging 1.14 0.984 1.158 1 5912.0 5484.26 5323.0 5614.0 [5533, 5533, 5467, 5583, 5536, 5502, 5482, 5378, 5498, 5436, 5410, 5445, 5518, 5497, 5608, 5438, 5549, 5519, 5480, 5510, 5506, 5438, 5479, 5485, 5470, 5404, 5537, 5483, 5499, 5490, 5463, 5450, 5486, 5466, 5496, 5360, 5323, 5537, 5505, 5512, 5422, 5437, 5508, 5489, 5470, 5421, 5510, 5482, 5458, 5488, 5486, 5542, 5475, 5519, 5465, 5470, 5535, 5495, 5418, 5508, 5508, 5397, 5587, 5506, 5440, 5522, 5466, 5453, 5411, 5514, 5386, 5359, 5440, 5511, 5559, 5489, 5464, 5509, 5500, 5471, 5499, 5501, 5465, 5575, 5527, 5555, 5542, 5561, 5514, 5422, 5410, 5538, 5479, 5435, 5614, 5530, 5462, 5508, 5501, 5387] 5188.0 5572.18 5425.0 5715.0 [5547, 5567, 5553, 5492, 5572, 5617, 5549, 5641, 5603, 5596, 5715, 5573, 5604, 5603, 5425, 5572, 5490, 5569, 5562, 5530, 5586, 5540, 5606, 5561, 5586, 5658, 5516, 5556, 5542, 5567, 5597, 5600, 5560, 5595, 5578, 5661, 5702, 5525, 5583, 5548, 5598, 5628, 5559, 5563, 5610, 5653, 5557, 5585, 5633, 5580, 5558, 5561, 5571, 5559, 5553, 5571, 5546, 5567, 5572, 5560, 5484, 5630, 5437, 5568, 5597, 5555, 5583, 5624, 5644, 5482, 5617, 5686, 5621, 5524, 5479, 5565, 5589, 5599, 5555, 5549, 5534, 5582, 5623, 5477, 5533, 5535, 5499, 5510, 5572, 5623, 5655, 5515, 5520, 5632, 5463, 5589, 5565, 5566, 5563, 5643] Breast-Cancer SBS39 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 11272.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS39 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 11272.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS39 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 11272.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS39 T>G 93.0 79.0 88.53 87.19 0.5195615554978972 0.9495922203754403 1.526 11272.0 Lagging 1.177 1.015 1.159 1 93.0 88.53 73.0 108.0 [87, 79, 90, 103, 79, 83, 77, 83, 79, 91, 80, 88, 81, 91, 78, 94, 86, 84, 89, 85, 89, 108, 90, 86, 87, 92, 81, 81, 86, 91, 92, 97, 96, 86, 91, 87, 86, 90, 85, 80, 87, 82, 82, 96, 82, 100, 92, 108, 87, 92, 82, 94, 90, 92, 89, 90, 74, 91, 94, 86, 85, 85, 95, 83, 73, 81, 92, 103, 94, 81, 92, 90, 93, 102, 99, 81, 98, 89, 88, 89, 85, 87, 77, 85, 89, 85, 85, 84, 96, 93, 82, 90, 96, 91, 88, 87, 102, 99, 89, 92] 79.0 87.19 69.0 105.0 [89, 95, 88, 69, 98, 94, 91, 94, 90, 86, 101, 83, 96, 81, 97, 83, 92, 88, 85, 86, 83, 71, 85, 88, 95, 87, 90, 94, 87, 87, 76, 86, 76, 87, 84, 91, 93, 83, 90, 92, 80, 87, 84, 84, 87, 81, 79, 75, 88, 89, 85, 76, 84, 86, 89, 84, 101, 91, 81, 95, 94, 92, 83, 90, 105, 91, 86, 73, 86, 91, 80, 86, 82, 81, 77, 97, 80, 91, 86, 95, 88, 90, 95, 96, 88, 87, 86, 94, 80, 90, 96, 85, 81, 90, 94, 85, 81, 73, 87, 90] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS39 C>G Lagging ['Breast-Cancer'] 1 [] 0 [] 0 [] 0 [] 0 [] 0 ['Breast-Cancer'] 1 1.1