# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 235.648 E:A[C>A]A 241.212 A:A[C>G]A 46.139 E:A[C>G]A 51.031 A:A[C>T]A 58.705 E:A[C>T]A 60.482 A:A[T>A]A 56.616 E:A[T>A]A 60.253 A:A[T>C]A 41.852 E:A[T>C]A 40.965 A:A[T>G]A 22.997 E:A[T>G]A 25.959 A:A[C>A]C 136.111 E:A[C>A]C 144.381 A:A[C>G]C 30.066 E:A[C>G]C 26.582 A:A[C>T]C 29.609 E:A[C>T]C 30.418 A:A[T>A]C 32.041 E:A[T>A]C 34.007 A:A[T>C]C 23.815 E:A[T>C]C 24.158 A:A[T>G]C 11.744 E:A[T>G]C 11.984 A:A[C>A]G 25.76 E:A[C>A]G 26.975 A:A[C>G]G 9.213 E:A[C>G]G 10.386 A:A[C>T]G 103.278 E:A[C>T]G 108.925 A:A[T>A]G 18.551 E:A[T>A]G 19.529 A:A[T>C]G 21.58 E:A[T>C]G 23.009 A:A[T>G]G 42.991 E:A[T>G]G 42.868 A:A[C>A]T 139.976 E:A[C>A]T 139.599 A:A[C>G]T 38.296 E:A[C>G]T 39.879 A:A[C>T]T 35.782 E:A[C>T]T 34.299 A:A[T>A]T 60.372 E:A[T>A]T 59.8 A:A[T>C]T 38.391 E:A[T>C]T 37.617 A:A[T>G]T 43.055 E:A[T>G]T 38.176 A:C[C>A]A 5929.039 E:C[C>A]A 6160.031 A:C[C>G]A 24.401 E:C[C>G]A 26.153 A:C[C>T]A 71.171 E:C[C>T]A 73.908 A:C[T>A]A 24.662 E:C[T>A]A 27.543 A:C[T>C]A 26.527 E:C[T>C]A 28.563 A:C[T>G]A 15.51 E:C[T>G]A 16.204 A:C[C>A]C 870.955 E:C[C>A]C 854.285 A:C[C>G]C 13.773 E:C[C>G]C 15.236 A:C[C>T]C 96.021 E:C[C>T]C 93.424 A:C[T>A]C 28.862 E:C[T>A]C 30.956 A:C[T>C]C 43.915 E:C[T>C]C 43.191 A:C[T>G]C 17.525 E:C[T>G]C 16.995 A:C[C>A]G 773.647 E:C[C>A]G 760.935 A:C[C>G]G 14.408 E:C[C>G]G 16.08 A:C[C>T]G 44.755 E:C[C>T]G 45.369 A:C[T>A]G 45.667 E:C[T>A]G 44.677 A:C[T>C]G 36.64 E:C[T>C]G 36.945 A:C[T>G]G 44.967 E:C[T>G]G 41.497 A:C[C>A]T 2720.403 E:C[C>A]T 2690.274 A:C[C>G]T 19.844 E:C[C>G]T 17.736 A:C[C>T]T 69.394 E:C[C>T]T 69.517 A:C[T>A]T 45.058 E:C[T>A]T 48.008 A:C[T>C]T 70.847 E:C[T>C]T 64.695 A:C[T>G]T 133.951 E:C[T>G]T 120.708 A:G[C>A]A 193.304 E:G[C>A]A 196.718 A:G[C>G]A 20.384 E:G[C>G]A 22.119 A:G[C>T]A 41.261 E:G[C>T]A 40.692 A:G[T>A]A 19.382 E:G[T>A]A 19.552 A:G[T>C]A 32.903 E:G[T>C]A 32.429 A:G[T>G]A 12.616 E:G[T>G]A 11.37 A:G[C>A]C 81.606 E:G[C>A]C 73.739 A:G[C>G]C 18.659 E:G[C>G]C 15.233 A:G[C>T]C 40.153 E:G[C>T]C 42.255 A:G[T>A]C 18.459 E:G[T>A]C 17.652 A:G[T>C]C 47.935 E:G[T>C]C 46.27 A:G[T>G]C 19.324 E:G[T>G]C 18.278 A:G[C>A]G 16.34 E:G[C>A]G 13.787 A:G[C>G]G 20.197 E:G[C>G]G 18.629 A:G[C>T]G 88.695 E:G[C>T]G 88.037 A:G[T>A]G 22.803 E:G[T>A]G 22.628 A:G[T>C]G 33.891 E:G[T>C]G 32.337 A:G[T>G]G 75.114 E:G[T>G]G 73.482 A:G[C>A]T 132.906 E:G[C>A]T 138.526 A:G[C>G]T 13.867 E:G[C>G]T 14.345 A:G[C>T]T 49.993 E:G[C>T]T 48.433 A:G[T>A]T 32.299 E:G[T>A]T 31.041 A:G[T>C]T 68.151 E:G[T>C]T 63.278 A:G[T>G]T 66.905 E:G[T>G]T 66.089 A:T[C>A]A 314.35 E:T[C>A]A 298.29 A:T[C>G]A 60.6 E:T[C>G]A 58.88 A:T[C>T]A 114.355 E:T[C>T]A 110.412 A:T[T>A]A 66.827 E:T[T>A]A 64.934 A:T[T>C]A 29.567 E:T[T>C]A 30.16 A:T[T>G]A 19.415 E:T[T>G]A 19.179 A:T[C>A]C 161.439 E:T[C>A]C 160.064 A:T[C>G]C 35.656 E:T[C>G]C 35.094 A:T[C>T]C 147.228 E:T[C>T]C 147.037 A:T[T>A]C 11.96 E:T[T>A]C 12.847 A:T[T>C]C 48.683 E:T[T>C]C 47.46 A:T[T>G]C 10.751 E:T[T>G]C 9.693 A:T[C>A]G 28.329 E:T[C>A]G 30.029 A:T[C>G]G 18.579 E:T[C>G]G 16.095 A:T[C>T]G 52.596 E:T[C>T]G 51.713 A:T[T>A]G 11.533 E:T[T>A]G 10.642 A:T[T>C]G 28.831 E:T[T>C]G 27.741 A:T[T>G]G 36.479 E:T[T>G]G 35.948 A:T[C>A]T 585.133 E:T[C>A]T 554.141 A:T[C>G]T 90.522 E:T[C>G]T 85.908 A:T[C>T]T 139.537 E:T[C>T]T 130.231 A:T[T>A]T 45.433 E:T[T>A]T 44.542 A:T[T>C]T 58.564 E:T[T>C]T 55.322 A:T[T>G]T 103.199 E:T[T>G]T 103.868 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Skin-Melanoma SBS38 C>A 12100.0 11891.0 12021.91 12263.8 0.0405482474992968 0.1298118257760774 98.973 24240.0 Lagging 1.018 0.98 1.038 12100.0 12021.91 11870.0 12190.0 [11967, 11949, 12066, 11936, 11986, 11971, 12011, 12013, 12026, 12059, 12190, 12065, 11962, 11983, 12030, 12076, 11954, 12036, 12067, 12179, 12090, 11929, 12103, 12135, 12127, 12050, 12026, 12109, 12035, 11910, 11918, 12089, 12003, 11997, 11961, 11972, 12065, 11896, 12159, 12009, 12047, 11886, 11911, 12037, 11969, 12038, 12114, 12052, 11989, 12007, 12026, 11996, 12174, 12005, 12021, 12056, 12116, 12036, 12014, 11972, 11939, 11954, 11996, 11899, 12142, 12029, 12180, 11941, 12017, 12017, 12092, 12162, 12077, 12079, 11897, 12146, 12085, 12005, 11983, 11973, 11893, 11870, 11916, 11997, 11966, 11943, 11988, 11882, 11980, 12075, 12032, 12157, 12104, 12092, 12025, 12157, 12040, 12007, 11922, 11957] 11891.0 12263.8 12086.0 12433.0 [12306, 12231, 12198, 12295, 12291, 12218, 12342, 12201, 12275, 12200, 12139, 12181, 12310, 12228, 12280, 12209, 12229, 12253, 12273, 12167, 12255, 12266, 12291, 12115, 12249, 12222, 12149, 12182, 12340, 12388, 12334, 12221, 12293, 12287, 12257, 12326, 12317, 12335, 12095, 12222, 12282, 12414, 12305, 12305, 12378, 12274, 12217, 12223, 12304, 12192, 12259, 12347, 12180, 12261, 12221, 12216, 12167, 12288, 12335, 12310, 12408, 12337, 12337, 12433, 12123, 12327, 12157, 12257, 12263, 12279, 12245, 12086, 12287, 12208, 12351, 12112, 12209, 12335, 12314, 12260, 12352, 12386, 12314, 12390, 12319, 12325, 12337, 12319, 12309, 12230, 12281, 12129, 12177, 12229, 12259, 12179, 12186, 12283, 12287, 12313] Skin-Melanoma SBS38 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 24240.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS38 C>T 62.0 65.0 60.15 62.34 1.0 1.0 0.524 24240.0 Leading 1.048 1.036 1.012 62.0 60.15 44.0 77.0 [52, 59, 61, 57, 50, 68, 72, 58, 51, 69, 72, 62, 55, 56, 63, 68, 61, 53, 63, 71, 53, 59, 61, 55, 74, 55, 65, 68, 77, 58, 62, 44, 53, 62, 61, 63, 59, 52, 71, 49, 62, 52, 57, 69, 56, 57, 59, 52, 54, 65, 61, 56, 61, 60, 58, 56, 61, 60, 66, 60, 62, 67, 49, 49, 69, 63, 51, 61, 58, 66, 60, 60, 59, 54, 50, 56, 58, 66, 65, 50, 63, 58, 64, 64, 56, 65, 58, 58, 62, 67, 64, 60, 55, 60, 68, 55, 60, 65, 70, 66] 65.0 62.34 48.0 75.0 [71, 63, 61, 67, 67, 60, 56, 66, 73, 60, 49, 65, 67, 61, 63, 58, 64, 67, 61, 56, 74, 67, 62, 70, 48, 65, 52, 58, 50, 59, 58, 75, 67, 61, 56, 62, 56, 66, 55, 74, 56, 72, 68, 58, 70, 64, 61, 69, 69, 57, 55, 68, 63, 63, 61, 69, 60, 60, 59, 56, 55, 55, 67, 68, 55, 62, 73, 63, 66, 57, 63, 61, 63, 66, 73, 65, 63, 58, 56, 66, 62, 61, 56, 59, 63, 60, 62, 67, 64, 53, 60, 63, 71, 64, 57, 71, 64, 59, 54, 61] Skin-Melanoma SBS38 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 24240.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS38 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 24240.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Skin-Melanoma SBS38 T>G 65.0 57.0 63.21 61.32 0.70401396623321 1.0 0.503 24240.0 Lagging 1.14 1.031 1.106 1 65.0 63.21 45.0 78.0 [67, 54, 67, 49, 70, 53, 67, 65, 55, 63, 69, 63, 62, 78, 50, 59, 65, 45, 70, 63, 57, 64, 68, 68, 68, 62, 64, 55, 52, 57, 63, 59, 67, 63, 66, 62, 61, 68, 55, 70, 60, 66, 61, 61, 71, 74, 52, 60, 57, 73, 77, 62, 67, 51, 56, 69, 62, 65, 70, 67, 63, 65, 53, 60, 60, 63, 69, 60, 66, 56, 61, 63, 70, 62, 70, 65, 63, 62, 66, 65, 65, 71, 59, 65, 68, 65, 57, 63, 65, 74, 64, 70, 56, 72, 68, 52, 64, 68, 70, 59] 57.0 61.32 47.0 76.0 [53, 66, 57, 75, 61, 67, 59, 58, 71, 51, 56, 64, 62, 47, 70, 63, 61, 76, 56, 67, 68, 61, 57, 62, 57, 64, 62, 66, 66, 67, 61, 64, 54, 67, 61, 68, 64, 53, 70, 60, 62, 65, 63, 62, 51, 48, 68, 67, 69, 59, 48, 59, 56, 66, 66, 51, 66, 65, 60, 58, 61, 65, 66, 66, 69, 58, 58, 65, 61, 61, 67, 62, 53, 61, 52, 66, 60, 69, 58, 58, 60, 56, 63, 59, 55, 63, 71, 62, 62, 55, 59, 55, 68, 52, 51, 70, 61, 54, 54, 65] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change