# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 164.81 E:A[C>A]A 189.506 A:A[C>G]A 743.838 E:A[C>G]A 619.579 A:A[C>T]A 331.982 E:A[C>T]A 357.54 A:A[T>A]A 171.313 E:A[T>A]A 158.201 A:A[T>C]A 4345.328 E:A[T>C]A 4543.672 A:A[T>G]A 1033.472 E:A[T>G]A 1265.806 A:A[C>A]C 93.301 E:A[C>A]C 94.053 A:A[C>G]C 206.851 E:A[C>G]C 190.514 A:A[C>T]C 240.13 E:A[C>T]C 280.48 A:A[T>A]C 70.826 E:A[T>A]C 71.112 A:A[T>C]C 2445.469 E:A[T>C]C 2875.016 A:A[T>G]C 544.127 E:A[T>G]C 706.408 A:A[C>A]G 36.211 E:A[C>A]G 49.097 A:A[C>G]G 22.355 E:A[C>G]G 18.904 A:A[C>T]G 491.747 E:A[C>T]G 632.851 A:A[T>A]G 47.528 E:A[T>A]G 49.938 A:A[T>C]G 1132.141 E:A[T>C]G 1291.161 A:A[T>G]G 618.124 E:A[T>G]G 759.654 A:A[C>A]T 236.52 E:A[C>A]T 299.525 A:A[C>G]T 384.756 E:A[C>G]T 334.915 A:A[C>T]T 441.552 E:A[C>T]T 543.644 A:A[T>A]T 351.446 E:A[T>A]T 345.127 A:A[T>C]T 3994.752 E:A[T>C]T 4256.381 A:A[T>G]T 1865.919 E:A[T>G]T 2316.016 A:C[C>A]A 284.572 E:C[C>A]A 338.645 A:C[C>G]A 5.304 E:C[C>G]A 4.803 A:C[C>T]A 129.716 E:C[C>T]A 159.154 A:C[T>A]A 112.453 E:C[T>A]A 122.683 A:C[T>C]A 1521.454 E:C[T>C]A 1664.082 A:C[T>G]A 202.631 E:C[T>G]A 256.887 A:C[C>A]C 80.533 E:C[C>A]C 93.638 A:C[C>G]C 2.278 E:C[C>G]C 2.12 A:C[C>T]C 126.538 E:C[C>T]C 162.21 A:C[T>A]C 69.043 E:C[T>A]C 84.397 A:C[T>C]C 1211.295 E:C[T>C]C 1468.272 A:C[T>G]C 81.424 E:C[T>G]C 96.919 A:C[C>A]G 33.86 E:C[C>A]G 39.999 A:C[C>G]G 1.957 E:C[C>G]G 1.204 A:C[C>T]G 188.329 E:C[C>T]G 234.189 A:C[T>A]G 97.408 E:C[T>A]G 108.714 A:C[T>C]G 535.959 E:C[T>C]G 618.801 A:C[T>G]G 214.855 E:C[T>G]G 265.693 A:C[C>A]T 279.483 E:C[C>A]T 351.262 A:C[C>G]T 5.507 E:C[C>G]T 4.991 A:C[C>T]T 379.227 E:C[C>T]T 480.751 A:C[T>A]T 238.044 E:C[T>A]T 278.159 A:C[T>C]T 2407.118 E:C[T>C]T 2880.241 A:C[T>G]T 322.225 E:C[T>G]T 386.835 A:G[C>A]A 116.703 E:G[C>A]A 114.599 A:G[C>G]A 87.48 E:G[C>G]A 71.145 A:G[C>T]A 183.577 E:G[C>T]A 201.453 A:G[T>A]A 42.125 E:G[T>A]A 40.94 A:G[T>C]A 4246.237 E:G[T>C]A 3762.534 A:G[T>G]A 387.536 E:G[T>G]A 481.378 A:G[C>A]C 48.184 E:G[C>A]C 51.94 A:G[C>G]C 34.87 E:G[C>G]C 33.213 A:G[C>T]C 172.516 E:G[C>T]C 209.523 A:G[T>A]C 50.356 E:G[T>A]C 58.892 A:G[T>C]C 2356.835 E:G[T>C]C 2237.862 A:G[T>G]C 442.937 E:G[T>G]C 559.976 A:G[C>A]G 10.969 E:G[C>A]G 12.756 A:G[C>G]G 2.991 E:G[C>G]G 2.5 A:G[C>T]G 284.865 E:G[C>T]G 358.544 A:G[T>A]G 29.563 E:G[T>A]G 25.884 A:G[T>C]G 1601.448 E:G[T>C]G 1478.26 A:G[T>G]G 256.685 E:G[T>G]G 314.284 A:G[C>A]T 151.977 E:G[C>A]T 178.654 A:G[C>G]T 60.89 E:G[C>G]T 51.488 A:G[C>T]T 180.907 E:G[C>T]T 216.136 A:G[T>A]T 149.238 E:G[T>A]T 143.899 A:G[T>C]T 6867.906 E:G[T>C]T 5899.858 A:G[T>G]T 857.162 E:G[T>G]T 980.488 A:T[C>A]A 115.543 E:T[C>A]A 142.488 A:T[C>G]A 26.928 E:T[C>G]A 25.416 A:T[C>T]A 294.329 E:T[C>T]A 355.746 A:T[T>A]A 148.854 E:T[T>A]A 165.046 A:T[T>C]A 4322.626 E:T[T>C]A 4641.54 A:T[T>G]A 1095.634 E:T[T>G]A 1308.501 A:T[C>A]C 139.757 E:T[C>A]C 173.147 A:T[C>G]C 19.14 E:T[C>G]C 17.3 A:T[C>T]C 204.896 E:T[C>T]C 260.57 A:T[T>A]C 85.195 E:T[T>A]C 101.952 A:T[T>C]C 3648.786 E:T[T>C]C 4419.878 A:T[T>G]C 881.243 E:T[T>G]C 1081.24 A:T[C>A]G 84.405 E:T[C>A]G 104.694 A:T[C>G]G 4.478 E:T[C>G]G 4.766 A:T[C>T]G 219.791 E:T[C>T]G 277.959 A:T[T>A]G 86.267 E:T[T>A]G 94.712 A:T[T>C]G 1575.877 E:T[T>C]G 1803.048 A:T[T>G]G 874.91 E:T[T>G]G 1031.502 A:T[C>A]T 170.254 E:T[C>A]T 201.984 A:T[C>G]T 48.313 E:T[C>G]T 44.737 A:T[C>T]T 507.399 E:T[C>T]T 614.725 A:T[T>A]T 220.366 E:T[T>A]T 253.63 A:T[T>C]T 8007.61 E:T[T>C]T 9092.872 A:T[T>G]T 1936.839 E:T[T>G]T 2278.828 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list ColoRect-AdenoCA SBS37 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 21713.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS37 C>G 1660.0 1092.0 1347.41 1419.18 4.704989994910235e-18 3.757674341518061e-17 12.674 21713.0 Lagging 1.52 0.949 1.601 1 1 1 1 1660.0 1347.41 1262.0 1413.0 [1413, 1348, 1375, 1339, 1330, 1317, 1341, 1344, 1354, 1360, 1319, 1378, 1316, 1345, 1317, 1355, 1347, 1354, 1399, 1310, 1382, 1350, 1361, 1327, 1328, 1310, 1356, 1326, 1360, 1350, 1319, 1328, 1352, 1369, 1325, 1354, 1328, 1363, 1351, 1334, 1262, 1358, 1338, 1337, 1340, 1359, 1328, 1340, 1352, 1355, 1304, 1340, 1340, 1356, 1388, 1343, 1346, 1311, 1365, 1359, 1334, 1372, 1413, 1353, 1334, 1372, 1333, 1352, 1340, 1337, 1326, 1338, 1328, 1383, 1357, 1332, 1371, 1391, 1364, 1330, 1350, 1326, 1368, 1384, 1338, 1345, 1351, 1344, 1378, 1357, 1322, 1311, 1346, 1324, 1346, 1379, 1366, 1349, 1406, 1336] 1092.0 1419.18 1339.0 1475.0 [1341, 1419, 1381, 1436, 1423, 1423, 1431, 1423, 1413, 1387, 1451, 1388, 1460, 1432, 1442, 1378, 1405, 1436, 1369, 1473, 1399, 1420, 1401, 1431, 1406, 1451, 1424, 1432, 1413, 1427, 1412, 1460, 1416, 1413, 1428, 1431, 1436, 1421, 1408, 1443, 1471, 1407, 1422, 1440, 1454, 1411, 1448, 1431, 1396, 1434, 1446, 1424, 1408, 1413, 1402, 1408, 1435, 1437, 1405, 1432, 1429, 1404, 1339, 1397, 1449, 1388, 1415, 1407, 1448, 1455, 1466, 1447, 1438, 1396, 1408, 1426, 1389, 1357, 1413, 1425, 1391, 1428, 1407, 1384, 1455, 1422, 1399, 1433, 1387, 1420, 1445, 1475, 1422, 1424, 1432, 1402, 1404, 1392, 1360, 1433] ColoRect-AdenoCA SBS37 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 21713.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS37 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 21713.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS37 T>C 7664.0 11297.0 9596.51 9409.09 1.3632124211593697e-86 2.2925094600479223e-85 87.326 21713.0 Leading 1.474 0.98 1.503 1 1 1 1 7664.0 9596.51 9425.0 9848.0 [9525, 9721, 9470, 9587, 9848, 9620, 9542, 9599, 9673, 9513, 9591, 9474, 9530, 9592, 9628, 9609, 9659, 9548, 9425, 9537, 9693, 9678, 9512, 9707, 9604, 9690, 9552, 9678, 9568, 9713, 9557, 9496, 9609, 9714, 9634, 9530, 9513, 9570, 9517, 9674, 9636, 9649, 9638, 9656, 9689, 9623, 9564, 9547, 9542, 9660, 9603, 9641, 9524, 9580, 9670, 9504, 9606, 9563, 9551, 9688, 9567, 9609, 9578, 9614, 9631, 9712, 9657, 9607, 9619, 9633, 9753, 9596, 9525, 9483, 9621, 9511, 9567, 9580, 9545, 9598, 9500, 9469, 9468, 9527, 9543, 9549, 9661, 9561, 9556, 9680, 9537, 9621, 9636, 9579, 9791, 9643, 9600, 9619, 9613, 9458] 11297.0 9409.09 9211.0 9586.0 [9532, 9322, 9561, 9491, 9243, 9411, 9435, 9480, 9331, 9457, 9359, 9505, 9466, 9363, 9365, 9426, 9319, 9446, 9586, 9476, 9327, 9371, 9471, 9309, 9460, 9386, 9440, 9287, 9430, 9252, 9425, 9506, 9376, 9291, 9425, 9537, 9514, 9418, 9452, 9367, 9329, 9413, 9354, 9329, 9321, 9308, 9473, 9390, 9454, 9349, 9429, 9440, 9483, 9469, 9385, 9431, 9442, 9468, 9419, 9314, 9484, 9503, 9422, 9369, 9299, 9325, 9329, 9387, 9417, 9350, 9249, 9404, 9507, 9554, 9377, 9501, 9420, 9418, 9443, 9423, 9482, 9518, 9502, 9434, 9447, 9409, 9337, 9412, 9422, 9354, 9412, 9374, 9319, 9385, 9211, 9416, 9426, 9367, 9362, 9521] ColoRect-AdenoCA SBS37 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 21713.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lymph-BNHL SBS37 C>A 26.0 34.0 28.21 28.87 0.5766660743195932 1.0 1.296 4631.0 Leading 1.308 1.023 1.278 1 1 26.0 28.21 19.0 38.0 [27.0, 29.0, 28.0, 26.0, 30.0, 33.0, 25.0, 34.0, 28.0, 27.0, 25.0, 27.0, 26.0, 32.0, 38.0, 33.0, 36.0, 30.0, 29.0, 24.0, 34.0, 34.0, 31.0, 28.0, 33.0, 24.0, 28.0, 28.0, 29.0, 36.0, 26.0, 29.0, 29.0, 32.0, 28.0, 23.0, 32.0, 26.0, 33.0, 26.0, 30.0, 27.0, 25.0, 25.0, 24.0, 23.0, 25.0, 25.0, 24.0, 29.0, 27.0, 26.0, 31.0, 22.0, 27.0, 29.0, 32.0, 29.0, 28.0, 26.0, 23.0, 21.0, 33.0, 28.0, 28.0, 25.0, 27.0, 23.0, 31.0, 24.0, 34.0, 33.0, 30.0, 27.0, 31.0, 23.0, 32.0, 33.0, 34.0, 26.0, 27.0, 19.0, 28.0, 29.0, 29.0, 32.0, 27.0, 29.0, 32.0, 29.0, 25.0, 28.0, 24.0, 31.0, 27.0, 30.0, 25.0, 23.0, 27.0, 24.0] 34.0 28.87 21.0 38.0 [29.0, 30.0, 32.0, 28.0, 29.0, 22.0, 36.0, 25.0, 24.0, 30.0, 33.0, 34.0, 32.0, 25.0, 21.0, 23.0, 23.0, 29.0, 29.0, 34.0, 24.0, 23.0, 29.0, 28.0, 26.0, 32.0, 32.0, 31.0, 31.0, 24.0, 29.0, 25.0, 27.0, 27.0, 25.0, 34.0, 26.0, 35.0, 22.0, 28.0, 29.0, 31.0, 30.0, 28.0, 35.0, 33.0, 30.0, 31.0, 30.0, 25.0, 31.0, 27.0, 27.0, 38.0, 32.0, 30.0, 24.0, 27.0, 29.0, 33.0, 33.0, 35.0, 22.0, 29.0, 30.0, 31.0, 28.0, 31.0, 30.0, 36.0, 23.0, 23.0, 25.0, 29.0, 25.0, 34.0, 28.0, 27.0, 23.0, 33.0, 32.0, 35.0, 28.0, 31.0, 29.0, 25.0, 28.0, 27.0, 26.0, 27.0, 32.0, 26.0, 35.0, 25.0, 31.0, 25.0, 33.0, 32.0, 28.0, 31.0] Lymph-BNHL SBS37 C>G 114.0 127.0 114.47 117.57 0.7125584515795378 1.0 5.204 4631.0 Leading 1.114 1.027 1.085 114.0 114.47 94.0 134.0 [116.0, 122.0, 114.0, 112.0, 119.0, 113.0, 120.0, 113.0, 133.0, 123.0, 118.0, 120.0, 115.0, 98.0, 117.0, 111.0, 106.0, 118.0, 118.0, 111.0, 111.0, 114.0, 123.0, 116.0, 113.0, 111.0, 112.0, 120.0, 121.0, 116.0, 120.0, 121.0, 100.0, 112.0, 134.0, 114.0, 124.0, 110.0, 120.0, 113.0, 108.0, 109.0, 109.0, 110.0, 120.0, 110.0, 116.0, 112.0, 117.0, 108.0, 117.0, 118.0, 128.0, 125.0, 101.0, 106.0, 112.0, 116.0, 118.0, 94.0, 108.0, 108.0, 119.0, 125.0, 97.0, 108.0, 109.0, 100.0, 108.0, 110.0, 109.0, 117.0, 109.0, 116.0, 123.0, 106.0, 114.0, 117.0, 113.0, 119.0, 121.0, 119.0, 108.0, 113.0, 116.0, 106.0, 111.0, 123.0, 130.0, 106.0, 116.0, 127.0, 105.0, 110.0, 116.0, 119.0, 109.0, 112.0, 133.0, 116.0] 127.0 117.57 101.0 137.0 [107.0, 113.0, 116.0, 123.0, 116.0, 111.0, 115.0, 126.0, 105.0, 107.0, 118.0, 110.0, 123.0, 134.0, 120.0, 121.0, 124.0, 115.0, 115.0, 122.0, 121.0, 119.0, 111.0, 113.0, 121.0, 125.0, 121.0, 114.0, 105.0, 109.0, 113.0, 116.0, 126.0, 120.0, 102.0, 110.0, 104.0, 127.0, 109.0, 121.0, 123.0, 125.0, 122.0, 116.0, 110.0, 121.0, 111.0, 125.0, 111.0, 122.0, 123.0, 112.0, 110.0, 105.0, 131.0, 126.0, 124.0, 119.0, 111.0, 136.0, 119.0, 124.0, 118.0, 105.0, 131.0, 125.0, 126.0, 137.0, 127.0, 126.0, 123.0, 115.0, 119.0, 112.0, 112.0, 122.0, 123.0, 116.0, 122.0, 104.0, 113.0, 112.0, 131.0, 114.0, 116.0, 124.0, 120.0, 105.0, 106.0, 121.0, 117.0, 106.0, 126.0, 118.0, 115.0, 118.0, 124.0, 119.0, 101.0, 114.0] Lymph-BNHL SBS37 C>T 55.0 52.0 52.79 51.8 1.0 1.0 2.311 4631.0 Lagging 1.058 1.019 1.038 55.0 52.79 39.0 65.0 [48.0, 58.0, 50.0, 49.0, 49.0, 43.0, 55.0, 65.0, 49.0, 47.0, 52.0, 53.0, 50.0, 52.0, 58.0, 52.0, 58.0, 59.0, 49.0, 61.0, 43.0, 49.0, 49.0, 53.0, 59.0, 57.0, 58.0, 53.0, 60.0, 51.0, 52.0, 55.0, 54.0, 56.0, 56.0, 49.0, 48.0, 63.0, 49.0, 53.0, 65.0, 56.0, 46.0, 64.0, 50.0, 44.0, 49.0, 42.0, 54.0, 46.0, 44.0, 45.0, 58.0, 54.0, 52.0, 56.0, 57.0, 60.0, 54.0, 45.0, 55.0, 54.0, 61.0, 49.0, 57.0, 60.0, 47.0, 55.0, 52.0, 52.0, 46.0, 56.0, 49.0, 63.0, 45.0, 56.0, 63.0, 50.0, 62.0, 50.0, 55.0, 60.0, 51.0, 53.0, 39.0, 44.0, 54.0, 51.0, 50.0, 52.0, 45.0, 57.0, 57.0, 45.0, 46.0, 63.0, 54.0, 52.0, 57.0, 47.0] 52.0 51.8 37.0 65.0 [56.0, 50.0, 58.0, 56.0, 49.0, 54.0, 47.0, 43.0, 58.0, 56.0, 45.0, 55.0, 53.0, 49.0, 50.0, 47.0, 46.0, 48.0, 55.0, 42.0, 59.0, 51.0, 54.0, 53.0, 37.0, 46.0, 46.0, 54.0, 47.0, 52.0, 53.0, 50.0, 45.0, 55.0, 55.0, 55.0, 56.0, 44.0, 55.0, 52.0, 42.0, 48.0, 61.0, 41.0, 56.0, 58.0, 53.0, 65.0, 50.0, 57.0, 63.0, 60.0, 53.0, 49.0, 55.0, 47.0, 47.0, 42.0, 45.0, 61.0, 52.0, 49.0, 47.0, 57.0, 47.0, 47.0, 59.0, 52.0, 54.0, 49.0, 57.0, 51.0, 58.0, 42.0, 62.0, 52.0, 43.0, 55.0, 43.0, 56.0, 48.0, 47.0, 50.0, 49.0, 64.0, 60.0, 43.0, 56.0, 56.0, 51.0, 59.0, 49.0, 50.0, 62.0, 60.0, 42.0, 54.0, 52.0, 49.0, 58.0] Lymph-BNHL SBS37 T>A 71.0 69.0 67.31 67.23 1.0 1.0 3.023 4631.0 Lagging 1.029 1.001 1.028 71.0 67.31 48.0 81.0 [68.0, 71.0, 66.0, 71.0, 58.0, 73.0, 66.0, 62.0, 63.0, 61.0, 65.0, 75.0, 66.0, 63.0, 73.0, 62.0, 66.0, 67.0, 67.0, 67.0, 67.0, 64.0, 64.0, 68.0, 73.0, 69.0, 75.0, 70.0, 79.0, 65.0, 68.0, 65.0, 69.0, 67.0, 62.0, 76.0, 73.0, 70.0, 60.0, 61.0, 71.0, 48.0, 57.0, 71.0, 71.0, 70.0, 66.0, 64.0, 59.0, 68.0, 68.0, 60.0, 81.0, 63.0, 59.0, 62.0, 68.0, 72.0, 71.0, 61.0, 70.0, 58.0, 66.0, 61.0, 72.0, 65.0, 80.0, 58.0, 65.0, 71.0, 76.0, 74.0, 71.0, 66.0, 70.0, 69.0, 60.0, 79.0, 78.0, 66.0, 70.0, 73.0, 67.0, 71.0, 65.0, 65.0, 60.0, 68.0, 59.0, 79.0, 65.0, 62.0, 60.0, 63.0, 73.0, 70.0, 66.0, 72.0, 81.0, 62.0] 69.0 67.23 51.0 92.0 [66.0, 63.0, 63.0, 58.0, 80.0, 67.0, 68.0, 73.0, 71.0, 74.0, 72.0, 60.0, 65.0, 69.0, 65.0, 71.0, 74.0, 73.0, 67.0, 63.0, 69.0, 69.0, 72.0, 69.0, 60.0, 63.0, 58.0, 68.0, 62.0, 67.0, 65.0, 65.0, 58.0, 65.0, 68.0, 62.0, 64.0, 67.0, 68.0, 76.0, 62.0, 92.0, 73.0, 64.0, 62.0, 67.0, 72.0, 66.0, 75.0, 67.0, 64.0, 76.0, 51.0, 66.0, 78.0, 66.0, 67.0, 64.0, 68.0, 71.0, 67.0, 80.0, 70.0, 77.0, 62.0, 74.0, 57.0, 78.0, 67.0, 66.0, 62.0, 63.0, 61.0, 73.0, 60.0, 63.0, 80.0, 61.0, 60.0, 69.0, 64.0, 56.0, 72.0, 64.0, 73.0, 65.0, 79.0, 68.0, 69.0, 51.0, 65.0, 75.0, 72.0, 70.0, 62.0, 66.0, 71.0, 57.0, 52.0, 74.0] Lymph-BNHL SBS37 T>C 1333.0 1248.0 1258.98 1241.87 0.3544145732836174 0.7486428210613384 55.733 4631.0 Lagging 1.068 1.014 1.054 1333.0 1258.98 1206.0 1314.0 [1277.0, 1283.0, 1227.0, 1271.0, 1209.0, 1279.0, 1223.0, 1284.0, 1246.0, 1299.0, 1267.0, 1249.0, 1283.0, 1278.0, 1262.0, 1225.0, 1256.0, 1299.0, 1289.0, 1268.0, 1264.0, 1234.0, 1264.0, 1290.0, 1258.0, 1273.0, 1235.0, 1257.0, 1254.0, 1281.0, 1278.0, 1241.0, 1275.0, 1214.0, 1271.0, 1245.0, 1263.0, 1207.0, 1293.0, 1275.0, 1234.0, 1255.0, 1285.0, 1287.0, 1301.0, 1247.0, 1236.0, 1281.0, 1270.0, 1252.0, 1314.0, 1271.0, 1234.0, 1230.0, 1237.0, 1265.0, 1231.0, 1258.0, 1262.0, 1290.0, 1294.0, 1252.0, 1251.0, 1283.0, 1296.0, 1286.0, 1302.0, 1206.0, 1233.0, 1252.0, 1229.0, 1232.0, 1268.0, 1252.0, 1269.0, 1213.0, 1240.0, 1233.0, 1259.0, 1268.0, 1239.0, 1240.0, 1280.0, 1225.0, 1309.0, 1241.0, 1275.0, 1256.0, 1243.0, 1260.0, 1214.0, 1235.0, 1264.0, 1293.0, 1259.0, 1285.0, 1216.0, 1295.0, 1238.0, 1227.0] 1248.0 1241.87 1196.0 1302.0 [1231.0, 1211.0, 1278.0, 1226.0, 1287.0, 1214.0, 1280.0, 1211.0, 1250.0, 1196.0, 1234.0, 1219.0, 1226.0, 1225.0, 1243.0, 1262.0, 1261.0, 1210.0, 1222.0, 1246.0, 1231.0, 1256.0, 1235.0, 1204.0, 1251.0, 1234.0, 1257.0, 1242.0, 1258.0, 1233.0, 1252.0, 1248.0, 1222.0, 1290.0, 1221.0, 1271.0, 1229.0, 1293.0, 1214.0, 1198.0, 1269.0, 1237.0, 1227.0, 1234.0, 1205.0, 1276.0, 1249.0, 1229.0, 1228.0, 1237.0, 1205.0, 1267.0, 1266.0, 1287.0, 1276.0, 1212.0, 1261.0, 1239.0, 1251.0, 1209.0, 1216.0, 1235.0, 1251.0, 1225.0, 1220.0, 1230.0, 1209.0, 1271.0, 1250.0, 1275.0, 1302.0, 1254.0, 1216.0, 1253.0, 1227.0, 1278.0, 1241.0, 1267.0, 1240.0, 1246.0, 1242.0, 1277.0, 1222.0, 1264.0, 1203.0, 1231.0, 1213.0, 1253.0, 1270.0, 1251.0, 1275.0, 1254.0, 1235.0, 1197.0, 1250.0, 1231.0, 1268.0, 1223.0, 1232.0, 1255.0] Lymph-BNHL SBS37 T>G 816.0 686.0 738.4 718.05 0.05095679065352356 0.15943042391347448 32.434 4631.0 Lagging 1.19 1.028 1.157 1 816.0 738.4 695.0 774.0 [745.0, 735.0, 748.0, 715.0, 727.0, 746.0, 759.0, 714.0, 738.0, 706.0, 752.0, 737.0, 721.0, 758.0, 734.0, 742.0, 724.0, 710.0, 743.0, 720.0, 721.0, 750.0, 745.0, 716.0, 731.0, 740.0, 755.0, 713.0, 742.0, 751.0, 763.0, 765.0, 738.0, 714.0, 720.0, 752.0, 730.0, 709.0, 722.0, 759.0, 746.0, 713.0, 764.0, 724.0, 722.0, 760.0, 755.0, 754.0, 750.0, 707.0, 716.0, 721.0, 729.0, 730.0, 747.0, 746.0, 738.0, 756.0, 711.0, 762.0, 738.0, 772.0, 729.0, 757.0, 715.0, 755.0, 764.0, 760.0, 769.0, 747.0, 732.0, 704.0, 741.0, 764.0, 767.0, 717.0, 766.0, 745.0, 723.0, 723.0, 724.0, 761.0, 743.0, 741.0, 730.0, 714.0, 742.0, 724.0, 774.0, 748.0, 761.0, 760.0, 726.0, 695.0, 760.0, 754.0, 720.0, 735.0, 734.0, 745.0] 686.0 718.05 674.0 774.0 [705.0, 703.0, 705.0, 733.0, 735.0, 725.0, 706.0, 738.0, 717.0, 745.0, 715.0, 715.0, 720.0, 699.0, 725.0, 727.0, 728.0, 725.0, 730.0, 730.0, 745.0, 701.0, 704.0, 749.0, 714.0, 725.0, 714.0, 744.0, 720.0, 700.0, 700.0, 692.0, 728.0, 736.0, 739.0, 710.0, 723.0, 744.0, 721.0, 704.0, 732.0, 725.0, 687.0, 722.0, 746.0, 694.0, 694.0, 715.0, 720.0, 744.0, 748.0, 742.0, 720.0, 716.0, 702.0, 712.0, 726.0, 700.0, 732.0, 701.0, 711.0, 693.0, 713.0, 704.0, 739.0, 718.0, 682.0, 678.0, 694.0, 719.0, 731.0, 746.0, 722.0, 684.0, 680.0, 739.0, 697.0, 704.0, 721.0, 746.0, 736.0, 701.0, 702.0, 708.0, 726.0, 748.0, 711.0, 750.0, 674.0, 704.0, 706.0, 703.0, 728.0, 774.0, 710.0, 692.0, 736.0, 716.0, 721.0, 721.0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS37 C>G Lagging ['ColoRect-AdenoCA'] 1 ['ColoRect-AdenoCA'] 1 ['ColoRect-AdenoCA'] 1 ['ColoRect-AdenoCA'] 1 [] 0 [] 0 ['ColoRect-AdenoCA', 'Lymph-BNHL'] 2 1.5 SBS37 T>C Leading ['ColoRect-AdenoCA'] 1 ['ColoRect-AdenoCA'] 1 ['ColoRect-AdenoCA'] 1 ['ColoRect-AdenoCA'] 1 [] 0 [] 0 ['ColoRect-AdenoCA', 'Lymph-BNHL'] 2 1.5