# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
signature	cancer_type	dna_element	encode_element_list	fold_change_list	avg_fold_change	p_value_list	combined_p_value	q_value
SBS37	ColoRect-AdenoCA	H3K27ac-human	['ENCFF906VKA_large-intestine_Normal_H3K27ac-human', 'ENCFF324DUD_small-intestine_Normal_H3K27ac-human', 'ENCFF751HHK_sigmoid-colon_Normal_H3K27ac-human', 'ENCFF872JBU_transverse-colon_Normal_H3K27ac-human', 'ENCFF110SWT_transverse-colon_Normal_H3K27ac-human', 'ENCFF964IXJ_transverse-colon_Normal_H3K27ac-human', 'ENCFF338KAJ_transverse-colon_Normal_H3K27ac-human', 'ENCFF623OYB_colonic-mucosa_Normal_H3K27ac-human', 'ENCFF686KCG_muscle-layer-of-colon_Normal_H3K27ac-human', 'ENCFF494RDD_mucosa-of-rectum_Normal_H3K27ac-human', 'ENCFF876UVX_rectal-smooth-muscle-tissue_Normal_H3K27ac-human']	[0.974, 0.89, 0.939, 0.931, 0.933, 0.932, 0.918, 0.887, 0.973, 0.879, 0.897]	0.923	[0.2959543656696487, 0.0008207773471673451, 0.04156968989622861, 0.0036225877827927512, 0.010593273852642816, 0.004567902725648235, 0.0020798315426505455, 0.0008335783063384243, 0.2595628346444606, 0.0009603047076969883, 0.004977747678468556]	2.665272939975075e-13	9.675167711148878e-13
SBS37	ColoRect-AdenoCA	H3K27me3-human	['ENCFF039VVN_large-intestine_Normal_H3K27me3-human', 'ENCFF838TEA_small-intestine_Normal_H3K27me3-human', 'ENCFF638SEH_transverse-colon_Normal_H3K27me3-human', 'ENCFF552DIJ_colonic-mucosa_Normal_H3K27me3-human', 'ENCFF582OJN_muscle-layer-of-colon_Normal_H3K27me3-human', 'ENCFF109NAI_mucosa-of-rectum_Normal_H3K27me3-human']	[0.991, 1.034, 1.006, 0.924, 0.971, 0.971]	0.983	[0.7977582973747778, 0.309493044224308, 0.7895704369360564, 0.04677637102587245, 0.4402831258963861, 0.26930710647674017]	0.3229913242657003	0.4177006104507894
SBS37	ColoRect-AdenoCA	H3K36me3-human	['ENCFF380EGR_large-intestine_Normal_H3K36me3-human', 'ENCFF548RZD_small-intestine_Normal_H3K36me3-human', 'ENCFF323CLX_sigmoid-colon_Normal_H3K36me3-human', 'ENCFF857CPV_transverse-colon_Normal_H3K36me3-human', 'ENCFF789FGH_transverse-colon_Normal_H3K36me3-human', 'ENCFF348DWR_colonic-mucosa_Normal_H3K36me3-human', 'ENCFF415IQS_muscle-layer-of-colon_Normal_H3K36me3-human', 'ENCFF361PLG_mucosa-of-rectum_Normal_H3K36me3-human', 'ENCFF550MPO_rectal-smooth-muscle-tissue_Normal_H3K36me3-human']	[0.994, 0.943, 0.971, 0.98, 0.994, 0.964, 0.986, 0.973, 0.972]	0.975	[0.5679683223694788, 0.00023261443832873888, 0.13456891865994847, 0.0769179532588333, 0.6246043884636572, 0.07280400523480576, 0.20433422878273333, 0.060864328950271655, 0.1076437753785685]	0.00025770588013118955	0.0006031944450846389
SBS37	ColoRect-AdenoCA	H3K4me1-human	['ENCFF462DJZ_large-intestine_Normal_H3K4me1-human', 'ENCFF768QEG_small-intestine_Normal_H3K4me1-human', 'ENCFF409HTF_sigmoid-colon_Normal_H3K4me1-human', 'ENCFF357ALM_transverse-colon_Normal_H3K4me1-human', 'ENCFF940ZNY_transverse-colon_Normal_H3K4me1-human', 'ENCFF526FXD_transverse-colon_Normal_H3K4me1-human', 'ENCFF543AEK_transverse-colon_Normal_H3K4me1-human', 'ENCFF126QBU_colonic-mucosa_Normal_H3K4me1-human', 'ENCFF719HUM_muscle-layer-of-colon_Normal_H3K4me1-human', 'ENCFF088KTK_mucosa-of-rectum_Normal_H3K4me1-human', 'ENCFF903GOY_rectal-smooth-muscle-tissue_Normal_H3K4me1-human']	[0.995, 0.97, 0.976, 0.972, 1.002, 0.985, 0.969, 0.929, 0.977, 0.994, 0.957]	0.975	[0.7326769989091475, 0.04555570746058326, 0.0029655858194285387, 0.05228788839484271, 0.8356973886897595, 0.08823447406068016, 0.010760396608702484, 0.002482984145569854, 0.03301301449555833, 0.6957780471815442, 0.008882540756667381]	1.5624678030552224e-06	4.325533160406124e-06
SBS37	ColoRect-AdenoCA	H3K4me3-human	['ENCFF752YYA_large-intestine_Normal_H3K4me3-human', 'ENCFF268EZG_small-intestine_Normal_H3K4me3-human', 'ENCFF878SLR_sigmoid-colon_Normal_H3K4me3-human', 'ENCFF287UIZ_transverse-colon_Normal_H3K4me3-human', 'ENCFF024WGB_transverse-colon_Normal_H3K4me3-human', 'ENCFF005QIU_colonic-mucosa_Normal_H3K4me3-human', 'ENCFF435EWO_muscle-layer-of-colon_Normal_H3K4me3-human', 'ENCFF022NHS_mucosa-of-rectum_Normal_H3K4me3-human', 'ENCFF114PYZ_rectal-smooth-muscle-tissue_Normal_H3K4me3-human']	[0.935, 0.974, 1.002, 0.999, 0.996, 0.98, 1.021, 0.964, 1.006]	0.986	[0.08786805318586706, 0.4656850207629569, 0.9428118416708076, 0.9739152011899358, 0.8878824701092636, 0.6174668626439823, 0.5257773125534635, 0.3955682926737565, 0.8777337245191416]	0.8871578199064099	0.923000150482889
SBS37	ColoRect-AdenoCA	H3K9ac-human	['ENCFF126TQW_colonic-mucosa_Normal_H3K9ac-human', 'ENCFF182ODD_muscle-layer-of-colon_Normal_H3K9ac-human', 'ENCFF342OOL_mucosa-of-rectum_Normal_H3K9ac-human']	[0.942, 1.047, 0.99]	0.993	[0.07455811198482738, 0.13503553046574115, 0.812534633829467]	0.14197226929088555	0.20783960216296368
SBS37	ColoRect-AdenoCA	H3K9me3-human	['ENCFF368ZVT_large-intestine_Normal_H3K9me3-human', 'ENCFF536UOF_small-intestine_Normal_H3K9me3-human', 'ENCFF961RIU_transverse-colon_Normal_H3K9me3-human', 'ENCFF309ZHC_transverse-colon_Normal_H3K9me3-human']	[0.918, 1.029, 0.984, 0.974]	0.976	[0.046791015810453127, 0.16882929122519474, 0.032526929351788955, 0.22530609885264807]	0.012340536293326845	0.023245281176973543
SBS37	Lymph-BNHL	H2AFZ-human	['ENCFF514BDZ_B-cell_Normal_H2AFZ-human']	[1.145]	1.145	[0.06302044675810888]	0.06302044675810886	0.10223344071154875
SBS37	Lymph-BNHL	H3K27ac-human	['ENCFF884VAH_B-cell_Normal_H3K27ac-human']	[1.535]	1.535	[2.3214030223208635e-10]	2.3214030223208624e-10	7.711881728697099e-10
SBS37	Lymph-BNHL	H3K36me3-human	['ENCFF484III_B-cell_Normal_H3K36me3-human', 'ENCFF187GEP_B-cell_Normal_H3K36me3-human']	[1.762, 0.909]	1.335	[1.2746883791929024e-147, 0.0008718639283559871]	3.848423736116057e-148	4.18311667860547e-147
SBS37	Lymph-BNHL	H3K4me1-human	['ENCFF531GRE_B-cell_Normal_H3K4me1-human']	[1.205]	1.205	[5.710582182008503e-10]	5.71058218200851e-10	1.858482089259258e-09
SBS37	Lymph-BNHL	H3K4me2-human	['ENCFF900JSN_B-cell_Normal_H3K4me2-human']	[1.109]	1.109	[0.020484802368571177]	0.02048480236857118	0.037093056483344794
SBS37	Lymph-BNHL	H3K4me3-human	['ENCFF163MJF_B-cell_Normal_H3K4me3-human', 'ENCFF348DYH_B-cell_Normal_H3K4me3-human']	[1.564, 1.681]	1.623	[5.56650030918862e-10, 4.446914780743042e-10]	1.0852719578712484e-17	4.4158944881781334e-17
SBS37	Lymph-BNHL	H3K9ac-human	['ENCFF520FRP_B-cell_Normal_H3K9ac-human']	[1.595]	1.595	[3.4261550637234895e-15]	3.426155063723496e-15	1.3185714121872671e-14
SBS37	Lymph-BNHL	H3K9me3-human	['ENCFF257ZHZ_B-cell_Normal_H3K9me3-human']	[1.135]	1.135	[0.03000140886574985]	0.03000140886574985	0.052348979453334325
SBS37	Lymph-BNHL	H4K20me1-human	['ENCFF676OTA_B-cell_Normal_H4K20me1-human']	[1.607]	1.607	[3.275229451933892e-63]	3.2752294519339125e-63	2.41674142443662e-62