# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	585.718
E:A[C>A]A	658.049
A:A[C>G]A	34.556
E:A[C>G]A	30.476
A:A[C>T]A	92.612
E:A[C>T]A	102.001
A:A[T>A]A	54.474
E:A[T>A]A	60.82
A:A[T>C]A	100.202
E:A[T>C]A	88.814
A:A[T>G]A	18.372
E:A[T>G]A	18.975
A:A[C>A]C	189.773
E:A[C>A]C	193.579
A:A[C>G]C	32.795
E:A[C>G]C	39.184
A:A[C>T]C	56.142
E:A[C>T]C	61.647
A:A[T>A]C	34.025
E:A[T>A]C	30.177
A:A[T>C]C	28.133
E:A[T>C]C	38.385
A:A[T>G]C	4.337
E:A[T>G]C	9.099
A:A[C>A]G	38.572
E:A[C>A]G	46.976
A:A[C>G]G	5.001
E:A[C>G]G	6.044
A:A[C>T]G	127.709
E:A[C>T]G	148.636
A:A[T>A]G	36.763
E:A[T>A]G	37.123
A:A[T>C]G	67.719
E:A[T>C]G	73.872
A:A[T>G]G	12.605
E:A[T>G]G	12.545
A:A[C>A]T	483.737
E:A[C>A]T	461.058
A:A[C>G]T	41.143
E:A[C>G]T	35.061
A:A[C>T]T	73.97
E:A[C>T]T	69.855
A:A[T>A]T	63.728
E:A[T>A]T	66.367
A:A[T>C]T	87.917
E:A[T>C]T	91.554
A:A[T>G]T	21.679
E:A[T>G]T	20.509
A:C[C>A]A	1242.855
E:C[C>A]A	1383.241
A:C[C>G]A	24.123
E:C[C>G]A	13.974
A:C[C>T]A	119.745
E:C[C>T]A	129.26
A:C[T>A]A	23.965
E:C[T>A]A	26.492
A:C[T>C]A	30.698
E:C[T>C]A	30.193
A:C[T>G]A	8.912
E:C[T>G]A	9.459
A:C[C>A]C	466.114
E:C[C>A]C	443.426
A:C[C>G]C	23.406
E:C[C>G]C	20.381
A:C[C>T]C	143.123
E:C[C>T]C	124.976
A:C[T>A]C	18.531
E:C[T>A]C	23.701
A:C[T>C]C	32.626
E:C[T>C]C	40.346
A:C[T>G]C	6.539
E:C[T>G]C	4.536
A:C[C>A]G	117.792
E:C[C>A]G	124.242
A:C[C>G]G	2.905
E:C[C>G]G	5.449
A:C[C>T]G	85.468
E:C[C>T]G	80.891
A:C[T>A]G	40.224
E:C[T>A]G	33.313
A:C[T>C]G	31.28
E:C[T>C]G	37.6
A:C[T>G]G	13.4
E:C[T>G]G	13.803
A:C[C>A]T	1452.108
E:C[C>A]T	1434.618
A:C[C>G]T	37.071
E:C[C>G]T	40.516
A:C[C>T]T	109.313
E:C[C>T]T	107.699
A:C[T>A]T	46.189
E:C[T>A]T	38.693
A:C[T>C]T	48.009
E:C[T>C]T	37.627
A:C[T>G]T	18.287
E:C[T>G]T	17.817
A:G[C>A]A	1770.338
E:G[C>A]A	1770.007
A:G[C>G]A	15.21
E:G[C>G]A	17.108
A:G[C>T]A	65.972
E:G[C>T]A	76.498
A:G[T>A]A	10.021
E:G[T>A]A	13.076
A:G[T>C]A	51.823
E:G[T>C]A	48.247
A:G[T>G]A	0.667
E:G[T>G]A	2.051
A:G[C>A]C	467.423
E:G[C>A]C	502.297
A:G[C>G]C	19.642
E:G[C>G]C	21.108
A:G[C>T]C	74.595
E:G[C>T]C	70.905
A:G[T>A]C	12.379
E:G[T>A]C	16.131
A:G[T>C]C	24.98
E:G[T>C]C	23.386
A:G[T>G]C	3.152
E:G[T>G]C	6.687
A:G[C>A]G	98.966
E:G[C>A]G	98.626
A:G[C>G]G	2.384
E:G[C>G]G	1.454
A:G[C>T]G	102.71
E:G[C>T]G	108.565
A:G[T>A]G	15.461
E:G[T>A]G	20.102
A:G[T>C]G	37.697
E:G[T>C]G	25.253
A:G[T>G]G	20.318
E:G[T>G]G	19.305
A:G[C>A]T	1759.255
E:G[C>A]T	1700.164
A:G[C>G]T	24.581
E:G[C>G]T	24.665
A:G[C>T]T	81.089
E:G[C>T]T	68.578
A:G[T>A]T	22.06
E:G[T>A]T	19.175
A:G[T>C]T	47.629
E:G[T>C]T	45.992
A:G[T>G]T	7.584
E:G[T>G]T	9.268
A:T[C>A]A	3452.661
E:T[C>A]A	3468.189
A:T[C>G]A	69.762
E:T[C>G]A	81.316
A:T[C>T]A	239.56
E:T[C>T]A	228.987
A:T[T>A]A	46.88
E:T[T>A]A	46.316
A:T[T>C]A	55.041
E:T[T>C]A	54.742
A:T[T>G]A	16.746
E:T[T>G]A	15.917
A:T[C>A]C	1936.864
E:T[C>A]C	1922.845
A:T[C>G]C	51.465
E:T[C>G]C	42.222
A:T[C>T]C	139.59
E:T[C>T]C	142.109
A:T[T>A]C	19.265
E:T[T>A]C	17.603
A:T[T>C]C	38.964
E:T[T>C]C	33.136
A:T[T>G]C	8.413
E:T[T>G]C	11.301
A:T[C>A]G	320.82
E:T[C>A]G	318.655
A:T[C>G]G	5.165
E:T[C>G]G	7.617
A:T[C>T]G	64.61
E:T[C>T]G	75.239
A:T[T>A]G	20.358
E:T[T>A]G	16.143
A:T[T>C]G	21.725
E:T[T>C]G	29.571
A:T[T>G]G	19.301
E:T[T>G]G	22.5
A:T[C>A]T	4995.903
E:T[C>A]T	4782.409
A:T[C>G]T	162.471
E:T[C>G]T	130.172
A:T[C>T]T	174.697
E:T[C>T]T	156.549
A:T[T>A]T	55.517
E:T[T>A]T	46.071
A:T[T>C]T	52.84
E:T[T>C]T	47.188
A:T[T>G]T	25.882
E:T[T>G]T	36.229

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
Panc-Endocrine	SBS36	C>A	19028.0	18263.0	18714.69	18738.33	0.003855340856746476	0.01489036466920435	86.348	43187.0	Lagging	1.042	0.999	1.043							19028.0	18714.69	18489.0	18923.0	[18615, 18773, 18859, 18615, 18764, 18675, 18639, 18677, 18565, 18684, 18728, 18782, 18730, 18776, 18738, 18596, 18804, 18786, 18867, 18804, 18734, 18803, 18754, 18615, 18756, 18809, 18781, 18713, 18645, 18680, 18654, 18688, 18830, 18797, 18673, 18793, 18782, 18747, 18785, 18805, 18693, 18694, 18654, 18695, 18650, 18833, 18567, 18675, 18571, 18681, 18768, 18798, 18732, 18607, 18628, 18736, 18847, 18651, 18799, 18728, 18561, 18651, 18742, 18765, 18731, 18570, 18690, 18633, 18578, 18774, 18489, 18736, 18690, 18609, 18809, 18923, 18769, 18541, 18751, 18821, 18702, 18721, 18744, 18681, 18739, 18790, 18569, 18717, 18602, 18797, 18699, 18551, 18713, 18601, 18908, 18893, 18664, 18674, 18859, 18684]	18263.0	18738.33	18507.0	18982.0	[18909, 18802, 18603, 18829, 18748, 18816, 18718, 18815, 18898, 18745, 18793, 18742, 18680, 18678, 18712, 18872, 18665, 18699, 18614, 18710, 18630, 18680, 18656, 18798, 18704, 18671, 18688, 18737, 18895, 18811, 18830, 18717, 18627, 18589, 18703, 18686, 18700, 18707, 18648, 18637, 18710, 18692, 18800, 18701, 18797, 18566, 18779, 18734, 18775, 18751, 18693, 18678, 18774, 18717, 18818, 18636, 18603, 18856, 18705, 18712, 18893, 18855, 18719, 18817, 18652, 18883, 18886, 18794, 18832, 18710, 18909, 18740, 18716, 18815, 18573, 18549, 18674, 18920, 18721, 18652, 18698, 18734, 18669, 18753, 18760, 18718, 18863, 18775, 18982, 18688, 18889, 18773, 18753, 18883, 18507, 18547, 18768, 18719, 18625, 18760]
Panc-Endocrine	SBS36	C>G	440.0	399.0	418.87	425.73	0.2422560260227576	0.5690574412976893	1.943	43187.0	Lagging	1.103	0.984	1.121	1						440.0	418.87	388.0	452.0	[442, 421, 404, 426, 417, 392, 404, 401, 438, 411, 426, 417, 439, 402, 421, 404, 434, 390, 427, 436, 430, 390, 420, 401, 431, 414, 411, 426, 437, 393, 418, 409, 403, 419, 426, 447, 416, 404, 433, 412, 416, 447, 398, 424, 419, 438, 414, 427, 403, 420, 407, 432, 409, 389, 417, 445, 427, 438, 407, 413, 445, 440, 406, 427, 417, 432, 434, 421, 409, 388, 432, 420, 413, 415, 432, 404, 419, 398, 401, 421, 448, 431, 435, 415, 431, 406, 389, 425, 410, 431, 424, 408, 411, 420, 420, 452, 400, 429, 421, 425]	399.0	425.73	380.0	464.0	[410, 421, 446, 429, 428, 464, 443, 430, 415, 420, 423, 423, 416, 440, 423, 443, 402, 452, 424, 410, 421, 456, 424, 430, 413, 442, 428, 431, 429, 454, 438, 436, 444, 423, 418, 404, 428, 427, 414, 431, 441, 394, 436, 418, 414, 420, 431, 416, 429, 421, 422, 402, 422, 444, 449, 398, 408, 416, 423, 427, 405, 422, 436, 420, 436, 416, 393, 414, 438, 450, 410, 426, 419, 437, 410, 453, 415, 443, 444, 420, 413, 424, 426, 433, 422, 420, 453, 438, 426, 425, 408, 430, 439, 436, 422, 380, 432, 404, 429, 422]
Panc-Endocrine	SBS36	C>T	1357.0	1391.0	1374.48	1392.32	0.8294460606822196	1.0	6.363	43187.0	Leading	1.025	1.013	1.012							1357.0	1374.48	1311.0	1454.0	[1388, 1422, 1377, 1392, 1358, 1359, 1311, 1389, 1370, 1406, 1396, 1379, 1404, 1400, 1393, 1431, 1378, 1373, 1413, 1345, 1390, 1330, 1362, 1352, 1358, 1426, 1357, 1379, 1368, 1339, 1392, 1420, 1412, 1454, 1374, 1372, 1386, 1390, 1367, 1358, 1406, 1371, 1411, 1377, 1363, 1389, 1382, 1334, 1380, 1380, 1352, 1364, 1359, 1392, 1375, 1413, 1371, 1351, 1403, 1337, 1359, 1335, 1362, 1357, 1364, 1343, 1397, 1363, 1349, 1360, 1340, 1408, 1348, 1356, 1372, 1401, 1346, 1405, 1372, 1358, 1347, 1329, 1375, 1365, 1360, 1371, 1368, 1326, 1377, 1406, 1356, 1352, 1399, 1395, 1405, 1387, 1361, 1376, 1371, 1347]	1391.0	1392.32	1319.0	1451.0	[1364, 1343, 1398, 1414, 1395, 1403, 1451, 1369, 1400, 1368, 1348, 1403, 1367, 1347, 1378, 1347, 1394, 1394, 1341, 1415, 1383, 1425, 1378, 1405, 1399, 1333, 1402, 1410, 1401, 1426, 1381, 1337, 1353, 1319, 1421, 1386, 1397, 1380, 1403, 1413, 1384, 1397, 1350, 1387, 1399, 1391, 1382, 1423, 1402, 1382, 1384, 1415, 1419, 1391, 1392, 1368, 1405, 1412, 1359, 1444, 1417, 1451, 1405, 1387, 1372, 1429, 1381, 1398, 1442, 1384, 1411, 1344, 1434, 1392, 1406, 1376, 1403, 1381, 1358, 1410, 1401, 1435, 1388, 1399, 1398, 1409, 1387, 1432, 1393, 1352, 1415, 1406, 1388, 1389, 1391, 1398, 1406, 1357, 1399, 1431]
Panc-Endocrine	SBS36	T>A	351.0	365.0	366.61	356.55	0.5273761795285916	0.9589506363399218	1.658	43187.0	Leading	1.04	0.973	1.069							351.0	366.61	340.0	395.0	[379, 395, 369, 377, 363, 389, 366, 356, 375, 363, 365, 372, 362, 367, 383, 369, 383, 354, 359, 363, 371, 389, 362, 384, 367, 379, 369, 366, 373, 346, 341, 344, 364, 373, 374, 346, 351, 361, 364, 358, 386, 366, 364, 371, 381, 373, 346, 374, 367, 363, 355, 368, 376, 348, 383, 350, 352, 366, 367, 373, 386, 378, 371, 384, 375, 371, 371, 355, 340, 372, 374, 360, 385, 351, 378, 379, 348, 342, 365, 368, 360, 380, 360, 374, 350, 380, 366, 360, 369, 352, 342, 356, 383, 364, 376, 367, 361, 360, 358, 370]	365.0	356.55	321.0	389.0	[345, 336, 361, 340, 357, 347, 346, 366, 349, 364, 368, 327, 365, 354, 327, 358, 345, 369, 370, 362, 365, 336, 360, 321, 359, 335, 360, 356, 350, 388, 388, 372, 370, 362, 343, 372, 382, 349, 366, 366, 353, 348, 359, 361, 333, 360, 374, 348, 366, 363, 369, 350, 353, 364, 350, 366, 368, 352, 354, 356, 346, 342, 356, 342, 366, 359, 359, 371, 387, 340, 338, 374, 344, 357, 346, 348, 364, 389, 367, 354, 360, 344, 357, 350, 382, 334, 354, 359, 345, 371, 377, 358, 327, 348, 341, 369, 361, 357, 363, 346]
Panc-Endocrine	SBS36	T>C	625.0	657.0	644.93	637.42	0.452967452711355	0.8799820939507084	2.968	43187.0	Leading	1.051	0.988	1.064							625.0	644.93	599.0	697.0	[665, 627, 657, 611, 641, 619, 643, 641, 648, 659, 643, 642, 652, 648, 638, 654, 605, 647, 625, 634, 625, 657, 652, 601, 640, 669, 634, 646, 650, 660, 630, 656, 625, 647, 636, 670, 626, 655, 634, 655, 644, 659, 674, 643, 676, 660, 627, 637, 655, 643, 619, 644, 666, 647, 646, 623, 687, 653, 650, 633, 697, 674, 667, 649, 665, 658, 620, 632, 599, 635, 658, 625, 633, 650, 657, 672, 676, 661, 611, 661, 646, 619, 670, 648, 641, 668, 642, 603, 617, 649, 662, 657, 662, 650, 624, 635, 665, 612, 663, 607]	657.0	637.42	582.0	680.0	[609, 657, 609, 680, 630, 656, 634, 645, 633, 633, 632, 636, 649, 627, 633, 636, 680, 651, 649, 652, 661, 636, 629, 678, 626, 607, 638, 627, 625, 627, 646, 620, 652, 639, 641, 604, 651, 621, 669, 625, 642, 643, 605, 640, 617, 648, 655, 630, 631, 652, 652, 658, 621, 638, 641, 672, 584, 624, 642, 639, 582, 621, 628, 635, 640, 604, 651, 651, 671, 641, 635, 641, 637, 630, 617, 629, 613, 617, 665, 641, 641, 670, 635, 627, 629, 630, 636, 672, 645, 647, 624, 635, 628, 635, 643, 645, 609, 672, 616, 667]
Panc-Endocrine	SBS36	T>G	156.0	155.0	163.39	157.86	0.8735976953276594	1.0	0.72	43187.0	Lagging	1.006	1.035	0.972							156.0	163.39	143.0	182.0	[144, 161, 167, 170, 153, 152, 165, 156, 145, 157, 177, 158, 162, 160, 167, 148, 163, 158, 154, 168, 171, 151, 157, 147, 171, 173, 166, 161, 180, 169, 179, 162, 164, 169, 175, 174, 164, 150, 158, 167, 161, 170, 162, 167, 158, 160, 170, 163, 148, 158, 174, 174, 169, 182, 166, 155, 143, 157, 156, 173, 154, 160, 174, 167, 157, 162, 176, 153, 176, 162, 169, 167, 149, 157, 180, 165, 169, 151, 171, 173, 150, 172, 182, 176, 168, 170, 160, 168, 163, 149, 163, 162, 157, 154, 157, 158, 155, 169, 175, 180]	155.0	157.86	132.0	180.0	[180, 157, 153, 140, 156, 171, 157, 161, 175, 152, 150, 156, 156, 169, 157, 170, 163, 152, 179, 152, 156, 167, 161, 176, 154, 153, 156, 163, 150, 155, 141, 161, 154, 165, 148, 149, 158, 176, 158, 158, 161, 155, 156, 161, 160, 155, 151, 156, 176, 165, 152, 156, 153, 136, 150, 157, 176, 161, 163, 150, 166, 169, 143, 163, 159, 158, 146, 160, 149, 161, 152, 156, 168, 162, 145, 159, 159, 165, 151, 147, 177, 146, 132, 144, 151, 158, 156, 160, 163, 171, 161, 160, 175, 165, 159, 167, 164, 146, 141, 137]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS36	C>A	Lagging	[]	0	[]	0	[]	0	[]	0	[]	0	[]	0	['Panc-Endocrine']	1