# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types.
MutationType	Across_All_Cancer_Types
T:A[C>A]A	237.0
U:A[C>A]A	195.0
B:A[C>A]A	2.0
N:A[C>A]A	925.0
T:A[C>A]C	74.0
U:A[C>A]C	55.0
B:A[C>A]C	2.0
N:A[C>A]C	278.0
T:A[C>A]G	15.0
U:A[C>A]G	10.0
B:A[C>A]G	0.0
N:A[C>A]G	45.0
T:A[C>A]T	188.0
U:A[C>A]T	145.0
B:A[C>A]T	1.0
N:A[C>A]T	674.0
T:A[C>G]A	12.0
U:A[C>G]A	8.0
B:A[C>G]A	0.0
N:A[C>G]A	40.0
T:A[C>G]C	15.0
U:A[C>G]C	11.0
B:A[C>G]C	0.0
N:A[C>G]C	38.0
T:A[C>G]G	0.0
U:A[C>G]G	2.0
B:A[C>G]G	0.0
N:A[C>G]G	4.0
T:A[C>G]T	12.0
U:A[C>G]T	8.0
B:A[C>G]T	0.0
N:A[C>G]T	45.0
T:A[C>T]A	39.0
U:A[C>T]A	29.0
B:A[C>T]A	1.0
N:A[C>T]A	128.0
T:A[C>T]C	24.0
U:A[C>T]C	19.0
B:A[C>T]C	0.0
N:A[C>T]C	71.0
T:A[C>T]G	50.0
U:A[C>T]G	30.0
B:A[C>T]G	2.0
N:A[C>T]G	191.0
T:A[C>T]T	28.0
U:A[C>T]T	14.0
B:A[C>T]T	0.0
N:A[C>T]T	83.0
T:A[T>A]A	15.0
U:A[T>A]A	7.0
B:A[T>A]A	1.0
N:A[T>A]A	72.0
T:A[T>A]C	9.0
U:A[T>A]C	3.0
B:A[T>A]C	0.0
N:A[T>A]C	35.0
T:A[T>A]G	10.0
U:A[T>A]G	7.0
B:A[T>A]G	0.0
N:A[T>A]G	50.0
T:A[T>A]T	15.0
U:A[T>A]T	24.0
B:A[T>A]T	0.0
N:A[T>A]T	88.0
T:A[T>C]A	55.0
U:A[T>C]A	22.0
B:A[T>C]A	2.0
N:A[T>C]A	119.0
T:A[T>C]C	17.0
U:A[T>C]C	7.0
B:A[T>C]C	0.0
N:A[T>C]C	37.0
T:A[T>C]G	55.0
U:A[T>C]G	13.0
B:A[T>C]G	1.0
N:A[T>C]G	74.0
T:A[T>C]T	71.0
U:A[T>C]T	23.0
B:A[T>C]T	0.0
N:A[T>C]T	110.0
T:A[T>G]A	2.0
U:A[T>G]A	7.0
B:A[T>G]A	0.0
N:A[T>G]A	14.0
T:A[T>G]C	2.0
U:A[T>G]C	1.0
B:A[T>G]C	0.0
N:A[T>G]C	10.0
T:A[T>G]G	5.0
U:A[T>G]G	3.0
B:A[T>G]G	0.0
N:A[T>G]G	10.0
T:A[T>G]T	3.0
U:A[T>G]T	5.0
B:A[T>G]T	0.0
N:A[T>G]T	24.0
T:C[C>A]A	556.0
U:C[C>A]A	507.0
B:C[C>A]A	7.0
N:C[C>A]A	1786.0
T:C[C>A]C	183.0
U:C[C>A]C	150.0
B:C[C>A]C	4.0
N:C[C>A]C	615.0
T:C[C>A]G	48.0
U:C[C>A]G	54.0
B:C[C>A]G	0.0
N:C[C>A]G	130.0
T:C[C>A]T	527.0
U:C[C>A]T	558.0
B:C[C>A]T	7.0
N:C[C>A]T	1927.0
T:C[C>G]A	6.0
U:C[C>G]A	10.0
B:C[C>G]A	0.0
N:C[C>G]A	23.0
T:C[C>G]C	1.0
U:C[C>G]C	9.0
B:C[C>G]C	0.0
N:C[C>G]C	29.0
T:C[C>G]G	1.0
U:C[C>G]G	5.0
B:C[C>G]G	0.0
N:C[C>G]G	1.0
T:C[C>G]T	10.0
U:C[C>G]T	18.0
B:C[C>G]T	2.0
N:C[C>G]T	34.0
T:C[C>T]A	45.0
U:C[C>T]A	45.0
B:C[C>T]A	1.0
N:C[C>T]A	149.0
T:C[C>T]C	47.0
U:C[C>T]C	41.0
B:C[C>T]C	1.0
N:C[C>T]C	165.0
T:C[C>T]G	33.0
U:C[C>T]G	32.0
B:C[C>T]G	0.0
N:C[C>T]G	94.0
T:C[C>T]T	38.0
U:C[C>T]T	38.0
B:C[C>T]T	1.0
N:C[C>T]T	139.0
T:C[T>A]A	6.0
U:C[T>A]A	3.0
B:C[T>A]A	0.0
N:C[T>A]A	32.0
T:C[T>A]C	12.0
U:C[T>A]C	9.0
B:C[T>A]C	0.0
N:C[T>A]C	22.0
T:C[T>A]G	12.0
U:C[T>A]G	11.0
B:C[T>A]G	0.0
N:C[T>A]G	52.0
T:C[T>A]T	6.0
U:C[T>A]T	8.0
B:C[T>A]T	0.0
N:C[T>A]T	59.0
T:C[T>C]A	7.0
U:C[T>C]A	5.0
B:C[T>C]A	0.0
N:C[T>C]A	38.0
T:C[T>C]C	10.0
U:C[T>C]C	7.0
B:C[T>C]C	0.0
N:C[T>C]C	40.0
T:C[T>C]G	15.0
U:C[T>C]G	15.0
B:C[T>C]G	0.0
N:C[T>C]G	36.0
T:C[T>C]T	14.0
U:C[T>C]T	10.0
B:C[T>C]T	0.0
N:C[T>C]T	49.0
T:C[T>G]A	2.0
U:C[T>G]A	3.0
B:C[T>G]A	0.0
N:C[T>G]A	6.0
T:C[T>G]C	2.0
U:C[T>G]C	2.0
B:C[T>G]C	0.0
N:C[T>G]C	7.0
T:C[T>G]G	4.0
U:C[T>G]G	7.0
B:C[T>G]G	0.0
N:C[T>G]G	12.0
T:C[T>G]T	3.0
U:C[T>G]T	14.0
B:C[T>G]T	0.0
N:C[T>G]T	18.0
T:G[C>A]A	686.0
U:G[C>A]A	642.0
B:G[C>A]A	12.0
N:G[C>A]A	2440.0
T:G[C>A]C	197.0
U:G[C>A]C	162.0
B:G[C>A]C	5.0
N:G[C>A]C	627.0
T:G[C>A]G	43.0
U:G[C>A]G	32.0
B:G[C>A]G	1.0
N:G[C>A]G	112.0
T:G[C>A]T	638.0
U:G[C>A]T	684.0
B:G[C>A]T	14.0
N:G[C>A]T	2298.0
T:G[C>G]A	6.0
U:G[C>G]A	3.0
B:G[C>G]A	0.0
N:G[C>G]A	16.0
T:G[C>G]C	4.0
U:G[C>G]C	9.0
B:G[C>G]C	1.0
N:G[C>G]C	19.0
T:G[C>G]G	1.0
U:G[C>G]G	1.0
B:G[C>G]G	0.0
N:G[C>G]G	2.0
T:G[C>G]T	6.0
U:G[C>G]T	7.0
B:G[C>G]T	0.0
N:G[C>G]T	25.0
T:G[C>T]A	14.0
U:G[C>T]A	21.0
B:G[C>T]A	0.0
N:G[C>T]A	107.0
T:G[C>T]C	25.0
U:G[C>T]C	29.0
B:G[C>T]C	0.0
N:G[C>T]C	84.0
T:G[C>T]G	39.0
U:G[C>T]G	40.0
B:G[C>T]G	1.0
N:G[C>T]G	128.0
T:G[C>T]T	27.0
U:G[C>T]T	26.0
B:G[C>T]T	0.0
N:G[C>T]T	81.0
T:G[T>A]A	4.0
U:G[T>A]A	4.0
B:G[T>A]A	0.0
N:G[T>A]A	13.0
T:G[T>A]C	4.0
U:G[T>A]C	3.0
B:G[T>A]C	0.0
N:G[T>A]C	19.0
T:G[T>A]G	9.0
U:G[T>A]G	6.0
B:G[T>A]G	0.0
N:G[T>A]G	16.0
T:G[T>A]T	4.0
U:G[T>A]T	5.0
B:G[T>A]T	1.0
N:G[T>A]T	24.0
T:G[T>C]A	19.0
U:G[T>C]A	13.0
B:G[T>C]A	0.0
N:G[T>C]A	53.0
T:G[T>C]C	4.0
U:G[T>C]C	5.0
B:G[T>C]C	0.0
N:G[T>C]C	36.0
T:G[T>C]G	11.0
U:G[T>C]G	7.0
B:G[T>C]G	0.0
N:G[T>C]G	46.0
T:G[T>C]T	22.0
U:G[T>C]T	7.0
B:G[T>C]T	0.0
N:G[T>C]T	61.0
T:G[T>G]A	0.0
U:G[T>G]A	1.0
B:G[T>G]A	0.0
N:G[T>G]A	1.0
T:G[T>G]C	0.0
U:G[T>G]C	3.0
B:G[T>G]C	0.0
N:G[T>G]C	4.0
T:G[T>G]G	7.0
U:G[T>G]G	6.0
B:G[T>G]G	0.0
N:G[T>G]G	20.0
T:G[T>G]T	3.0
U:G[T>G]T	5.0
B:G[T>G]T	0.0
N:G[T>G]T	6.0
T:T[C>A]A	1351.0
U:T[C>A]A	1339.0
B:T[C>A]A	29.0
N:T[C>A]A	4819.0
T:T[C>A]C	752.0
U:T[C>A]C	715.0
B:T[C>A]C	9.0
N:T[C>A]C	2610.0
T:T[C>A]G	127.0
U:T[C>A]G	126.0
B:T[C>A]G	1.0
N:T[C>A]G	436.0
T:T[C>A]T	1797.0
U:T[C>A]T	1971.0
B:T[C>A]T	33.0
N:T[C>A]T	6746.0
T:T[C>G]A	28.0
U:T[C>G]A	31.0
B:T[C>G]A	2.0
N:T[C>G]A	90.0
T:T[C>G]C	15.0
U:T[C>G]C	23.0
B:T[C>G]C	1.0
N:T[C>G]C	47.0
T:T[C>G]G	1.0
U:T[C>G]G	2.0
B:T[C>G]G	0.0
N:T[C>G]G	6.0
T:T[C>G]T	48.0
U:T[C>G]T	53.0
B:T[C>G]T	2.0
N:T[C>G]T	181.0
T:T[C>T]A	72.0
U:T[C>T]A	95.0
B:T[C>T]A	0.0
N:T[C>T]A	312.0
T:T[C>T]C	45.0
U:T[C>T]C	41.0
B:T[C>T]C	2.0
N:T[C>T]C	168.0
T:T[C>T]G	28.0
U:T[C>T]G	24.0
B:T[C>T]G	1.0
N:T[C>T]G	94.0
T:T[C>T]T	64.0
U:T[C>T]T	54.0
B:T[C>T]T	2.0
N:T[C>T]T	211.0
T:T[T>A]A	10.0
U:T[T>A]A	16.0
B:T[T>A]A	0.0
N:T[T>A]A	53.0
T:T[T>A]C	3.0
U:T[T>A]C	3.0
B:T[T>A]C	0.0
N:T[T>A]C	27.0
T:T[T>A]G	1.0
U:T[T>A]G	3.0
B:T[T>A]G	0.0
N:T[T>A]G	20.0
T:T[T>A]T	10.0
U:T[T>A]T	9.0
B:T[T>A]T	0.0
N:T[T>A]T	65.0
T:T[T>C]A	18.0
U:T[T>C]A	19.0
B:T[T>C]A	1.0
N:T[T>C]A	64.0
T:T[T>C]C	14.0
U:T[T>C]C	6.0
B:T[T>C]C	0.0
N:T[T>C]C	41.0
T:T[T>C]G	6.0
U:T[T>C]G	8.0
B:T[T>C]G	0.0
N:T[T>C]G	34.0
T:T[T>C]T	18.0
U:T[T>C]T	12.0
B:T[T>C]T	0.0
N:T[T>C]T	63.0
T:T[T>G]A	2.0
U:T[T>G]A	9.0
B:T[T>G]A	0.0
N:T[T>G]A	18.0
T:T[T>G]C	2.0
U:T[T>G]C	3.0
B:T[T>G]C	0.0
N:T[T>G]C	9.0
T:T[T>G]G	4.0
U:T[T>G]G	4.0
B:T[T>G]G	0.0
N:T[T>G]G	22.0
T:T[T>G]T	7.0
U:T[T>G]T	9.0
B:T[T>G]T	1.0
N:T[T>G]T	38.0

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	genic_real_count	intergenic_real_count	genic_mean_sims_count	intergenic_mean_sims_count	genic_versus_intergenic_p_value	genic_versus_intergenic_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Transcribed_real_count	Transcribed_mean_sims_count	Transcribed_min_sims_count	Transcribed_max_sims_count	Transcribed_sims_count_list	UnTranscribed_real_count	UnTranscribed_mean_sims_count	UnTranscribed_min_sims_count	UnTranscribed_max_sims_count	UnTranscribed_sims_count_list	NonTranscribed_real_count	NonTranscribed_mean_sims_count	NonTranscribed_min_sims_count	NonTranscribed_max_sims_count	NonTranscribed_sims_count_list
Panc-Endocrine	SBS36	C>A	15172.0	26043.0	17872.45	23395.97	7.398061322125396e-81	1.1926603566524836e-79	86.294	47761.0	Intergenic	1.717	1.309	1.311	1	1	1				7583.0	8963.4	8801.0	9205.0	[9079, 8830, 8955, 8930, 9129, 8914, 9022, 8957, 8931, 9083, 9093, 8931, 8983, 8957, 8971, 8957, 8997, 8911, 8926, 9142, 8964, 8948, 9074, 8930, 8997, 8932, 8884, 9017, 8935, 9021, 8981, 8867, 9005, 9079, 8922, 8827, 8979, 8829, 8870, 8940, 9084, 8863, 8879, 9079, 8932, 8906, 8871, 8818, 8943, 8933, 8869, 8855, 8893, 8907, 8874, 8997, 8930, 9112, 8950, 8990, 8999, 8940, 8988, 9023, 9030, 8831, 8947, 8945, 8805, 8970, 8929, 9152, 9006, 8825, 8909, 9102, 8926, 8836, 9085, 8931, 8897, 8845, 8801, 9032, 8924, 8985, 9151, 8959, 9125, 9205, 9011, 9006, 9086, 8989, 8821, 8975, 8939, 9044, 8999, 8983]	7589.0	8909.05	8719.0	9121.0	[9027, 8843, 8790, 8919, 8906, 8929, 8949, 8938, 8967, 8847, 8792, 9005, 8812, 8761, 8799, 8873, 8829, 8809, 8858, 8798, 8871, 8931, 8827, 8889, 8915, 9032, 9005, 8761, 8923, 8921, 8771, 9036, 8885, 8917, 8900, 8957, 8941, 9074, 8927, 8961, 8975, 8797, 9036, 8899, 8934, 8973, 8954, 8906, 8947, 8877, 8907, 8984, 9030, 8859, 8865, 8862, 9100, 8731, 9040, 8892, 8872, 8830, 8998, 8897, 8991, 9097, 8925, 8835, 8988, 8786, 8756, 8754, 8888, 8918, 8852, 8884, 8924, 9121, 8719, 8867, 8866, 8936, 9072, 8898, 9038, 9041, 8904, 8881, 8906, 8830, 8939, 8875, 8759, 8928, 9022, 8844, 8840, 8904, 9009, 9048]	26043.0	23395.97	23191.0	23592.0	[23191, 23589, 23528, 23427, 23241, 23391, 23309, 23349, 23392, 23319, 23393, 23352, 23467, 23537, 23490, 23434, 23461, 23531, 23512, 23323, 23421, 23389, 23360, 23433, 23367, 23293, 23394, 23499, 23411, 23334, 23522, 23333, 23372, 23293, 23448, 23481, 23362, 23365, 23478, 23364, 23216, 23592, 23353, 23314, 23397, 23403, 23426, 23539, 23403, 23441, 23505, 23403, 23359, 23496, 23526, 23396, 23258, 23423, 23282, 23396, 23405, 23508, 23299, 23372, 23242, 23344, 23400, 23487, 23459, 23515, 23585, 23343, 23359, 23515, 23518, 23283, 23423, 23314, 23457, 23504, 23487, 23465, 23386, 23324, 23319, 23243, 23206, 23430, 23248, 23244, 23312, 23394, 23406, 23329, 23418, 23454, 23496, 23318, 23262, 23241]
Panc-Endocrine	SBS36	C>G	385.0	549.0	401.05	528.97	0.3988494892513332	0.8128149045608013	1.956	47761.0	Intergenic	1.426	1.319	1.081							177.0	203.5	174.0	234.0	[202, 207, 203, 219, 189, 204, 187, 204, 207, 184, 195, 222, 203, 205, 200, 200, 202, 234, 226, 205, 213, 198, 197, 224, 204, 224, 201, 223, 207, 186, 208, 188, 206, 185, 186, 202, 209, 192, 223, 223, 205, 209, 207, 174, 196, 204, 201, 206, 195, 195, 204, 199, 214, 184, 211, 195, 197, 232, 210, 200, 208, 197, 195, 187, 191, 205, 200, 194, 199, 200, 194, 186, 218, 201, 188, 194, 214, 186, 174, 222, 206, 205, 208, 214, 209, 219, 201, 209, 221, 192, 225, 197, 210, 209, 208, 205, 210, 213, 185, 216]	208.0	197.55	159.0	226.0	[208, 159, 193, 178, 199, 188, 193, 167, 210, 184, 211, 196, 200, 205, 192, 203, 197, 209, 173, 192, 199, 218, 217, 196, 200, 192, 191, 194, 176, 179, 206, 214, 212, 195, 198, 197, 200, 200, 191, 188, 196, 216, 202, 210, 212, 209, 192, 182, 192, 217, 184, 199, 184, 194, 187, 191, 188, 210, 208, 203, 203, 182, 210, 189, 193, 204, 196, 202, 197, 192, 198, 198, 203, 201, 194, 204, 207, 193, 205, 193, 198, 187, 199, 203, 195, 195, 226, 205, 198, 193, 198, 205, 196, 210, 183, 180, 217, 183, 208, 216]	549.0	528.97	488.0	565.0	[521, 562, 533, 535, 543, 534, 551, 559, 514, 558, 524, 511, 527, 519, 539, 528, 530, 489, 529, 534, 517, 514, 521, 508, 522, 515, 536, 515, 547, 565, 520, 525, 516, 551, 545, 533, 522, 541, 517, 518, 527, 504, 518, 547, 523, 517, 538, 540, 541, 517, 544, 536, 534, 554, 533, 543, 546, 488, 511, 530, 519, 549, 523, 553, 546, 521, 531, 533, 532, 536, 540, 547, 510, 528, 551, 533, 508, 553, 551, 514, 524, 540, 525, 512, 527, 517, 503, 513, 512, 544, 508, 530, 523, 516, 537, 544, 501, 532, 535, 497]
Panc-Endocrine	SBS36	C>T	1160.0	1891.0	1359.32	1695.37	3.0022422215856233e-07	1.6438148908013144e-06	6.388	47761.0	Intergenic	1.63	1.247	1.307	1	1	1				605.0	690.72	646.0	740.0	[688, 685, 702, 698, 698, 679, 684, 713, 715, 717, 653, 692, 713, 694, 700, 678, 647, 666, 713, 695, 700, 688, 691, 709, 698, 674, 738, 733, 651, 700, 701, 695, 700, 661, 703, 683, 647, 675, 680, 694, 692, 713, 717, 671, 695, 723, 660, 725, 713, 690, 694, 728, 675, 708, 704, 685, 646, 663, 666, 689, 710, 658, 704, 682, 669, 704, 705, 655, 671, 652, 699, 713, 698, 709, 680, 727, 667, 720, 662, 685, 700, 662, 727, 721, 667, 694, 684, 681, 649, 696, 740, 676, 701, 712, 709, 709, 656, 663, 688, 659]	555.0	668.6	623.0	717.0	[652, 667, 663, 675, 673, 664, 687, 702, 690, 660, 678, 685, 636, 658, 676, 669, 717, 692, 652, 626, 653, 692, 679, 654, 677, 683, 705, 656, 644, 633, 669, 649, 642, 690, 636, 670, 682, 684, 693, 673, 687, 673, 648, 651, 663, 635, 713, 682, 683, 698, 656, 623, 717, 678, 688, 692, 680, 643, 687, 690, 679, 655, 673, 660, 634, 642, 652, 697, 666, 651, 669, 650, 680, 637, 662, 670, 695, 656, 656, 692, 639, 710, 652, 685, 697, 681, 671, 649, 716, 668, 654, 654, 634, 673, 665, 639, 664, 645, 651, 664]	1891.0	1695.37	1611.0	1764.0	[1715, 1696, 1692, 1685, 1685, 1715, 1678, 1636, 1648, 1672, 1716, 1677, 1708, 1699, 1680, 1713, 1690, 1699, 1689, 1736, 1703, 1678, 1694, 1694, 1672, 1693, 1611, 1668, 1764, 1719, 1685, 1709, 1709, 1700, 1712, 1704, 1726, 1695, 1679, 1690, 1678, 1671, 1694, 1727, 1692, 1693, 1683, 1649, 1660, 1673, 1707, 1706, 1660, 1664, 1666, 1680, 1732, 1748, 1699, 1684, 1667, 1735, 1678, 1713, 1751, 1708, 1696, 1704, 1716, 1753, 1686, 1692, 1676, 1721, 1717, 1657, 1688, 1681, 1733, 1690, 1718, 1682, 1680, 1654, 1690, 1676, 1704, 1725, 1691, 1685, 1664, 1718, 1718, 1663, 1673, 1708, 1739, 1740, 1710, 1737]
Panc-Endocrine	SBS36	T>A	251.0	543.0	330.2	465.02	4.771637705347137e-05	0.0002224598915351815	1.662	47761.0	Intergenic	2.163	1.408	1.536	1	1	1	1			130.0	162.1	131.0	195.0	[165, 150, 164, 164, 148, 154, 158, 157, 143, 173, 159, 175, 182, 156, 161, 166, 157, 155, 169, 167, 149, 163, 150, 147, 163, 172, 154, 151, 154, 178, 158, 190, 164, 166, 162, 186, 137, 150, 161, 167, 158, 144, 163, 152, 169, 161, 151, 153, 168, 163, 152, 156, 169, 158, 167, 146, 158, 156, 181, 154, 149, 146, 164, 162, 163, 195, 193, 167, 174, 187, 153, 154, 163, 189, 177, 162, 166, 179, 147, 166, 167, 155, 159, 158, 171, 157, 155, 155, 179, 131, 165, 171, 155, 159, 156, 153, 183, 171, 175, 155]	121.0	168.1	136.0	193.0	[181, 167, 169, 184, 172, 170, 168, 169, 166, 177, 164, 170, 168, 169, 164, 172, 177, 171, 182, 165, 161, 168, 173, 145, 173, 174, 170, 176, 180, 161, 167, 165, 163, 171, 162, 149, 179, 166, 173, 154, 185, 165, 149, 159, 150, 161, 193, 161, 154, 170, 181, 186, 163, 161, 140, 178, 165, 188, 163, 170, 166, 170, 136, 153, 178, 169, 149, 160, 174, 183, 188, 157, 161, 153, 159, 184, 168, 150, 177, 181, 181, 174, 190, 164, 151, 172, 179, 162, 159, 174, 174, 175, 190, 173, 174, 165, 171, 152, 154, 163]	543.0	465.02	426.0	502.0	[449, 476, 461, 446, 474, 469, 470, 468, 484, 445, 474, 451, 443, 468, 471, 457, 460, 469, 447, 464, 483, 467, 474, 502, 462, 448, 471, 471, 461, 454, 470, 440, 471, 456, 473, 459, 481, 478, 459, 473, 454, 483, 484, 483, 477, 473, 452, 483, 471, 461, 463, 451, 465, 476, 488, 472, 472, 454, 451, 473, 477, 478, 495, 481, 454, 433, 452, 466, 451, 426, 458, 483, 471, 454, 462, 453, 463, 466, 471, 446, 448, 466, 447, 472, 475, 465, 465, 475, 456, 491, 456, 450, 448, 461, 464, 483, 441, 472, 466, 476]
Panc-Endocrine	SBS36	T>C	545.0	867.0	590.56	823.28	0.09131868352286474	0.26441005444322174	2.956	47761.0	Intergenic	1.591	1.394	1.141	1						361.0	284.62	254.0	311.0	[277, 293, 295, 302, 298, 300, 254, 274, 265, 272, 272, 282, 265, 294, 300, 280, 279, 306, 290, 270, 286, 271, 289, 275, 270, 295, 297, 274, 267, 291, 285, 280, 277, 297, 295, 278, 257, 271, 279, 271, 288, 269, 279, 284, 282, 288, 264, 261, 295, 284, 262, 294, 300, 278, 308, 297, 271, 299, 297, 296, 294, 293, 295, 293, 292, 289, 263, 279, 296, 286, 290, 274, 281, 271, 299, 282, 307, 283, 295, 291, 288, 289, 304, 290, 294, 309, 275, 277, 274, 311, 262, 295, 299, 265, 264, 294, 299, 278, 286, 287]	184.0	305.94	268.0	354.0	[299, 302, 324, 268, 331, 302, 296, 294, 329, 297, 354, 340, 316, 308, 296, 306, 305, 297, 309, 332, 309, 303, 315, 285, 329, 299, 280, 306, 302, 294, 312, 286, 302, 288, 303, 286, 308, 321, 301, 292, 305, 309, 326, 301, 316, 304, 316, 292, 282, 305, 302, 320, 318, 292, 300, 299, 322, 290, 302, 328, 329, 286, 297, 301, 306, 298, 280, 318, 301, 300, 289, 306, 320, 300, 282, 340, 296, 311, 322, 297, 316, 325, 298, 301, 292, 321, 317, 301, 315, 319, 311, 322, 307, 308, 302, 299, 294, 311, 307, 294]	867.0	823.28	781.0	871.0	[837, 820, 796, 844, 781, 812, 861, 845, 816, 847, 789, 796, 829, 812, 814, 832, 835, 812, 815, 811, 817, 838, 813, 850, 815, 824, 839, 835, 845, 827, 817, 851, 835, 832, 817, 848, 847, 822, 836, 850, 823, 837, 806, 831, 817, 819, 832, 858, 836, 830, 849, 801, 796, 845, 806, 820, 818, 825, 811, 788, 791, 836, 820, 822, 815, 824, 871, 819, 817, 826, 832, 831, 813, 842, 829, 796, 812, 821, 800, 824, 813, 798, 810, 823, 829, 789, 816, 839, 826, 784, 840, 796, 806, 842, 847, 820, 820, 825, 824, 830]
Panc-Endocrine	SBS36	T>G	138.0	217.0	150.43	205.02	0.4005045474791424	0.8146217337382792	0.743	47761.0	Intergenic	1.572	1.363	1.154	1						49.0	71.5	55.0	86.0	[72, 78, 86, 76, 74, 65, 81, 73, 59, 74, 78, 69, 71, 71, 74, 78, 58, 66, 69, 66, 78, 70, 84, 75, 72, 79, 71, 86, 66, 67, 75, 69, 63, 75, 72, 77, 69, 69, 67, 68, 70, 66, 73, 67, 64, 71, 80, 66, 65, 71, 56, 84, 72, 75, 67, 59, 72, 74, 60, 75, 74, 70, 74, 66, 76, 73, 71, 69, 83, 58, 77, 66, 68, 76, 67, 65, 71, 77, 72, 69, 72, 59, 63, 61, 82, 80, 86, 55, 76, 73, 58, 70, 78, 77, 86, 82, 82, 65, 71, 75]	89.0	78.93	60.0	97.0	[85, 71, 66, 84, 90, 85, 62, 78, 74, 82, 79, 76, 70, 81, 78, 60, 80, 79, 69, 78, 83, 80, 79, 82, 89, 83, 82, 81, 83, 63, 81, 75, 80, 84, 69, 81, 93, 82, 94, 91, 89, 74, 79, 86, 82, 79, 68, 79, 75, 80, 78, 89, 83, 91, 75, 70, 67, 69, 73, 68, 86, 92, 69, 91, 73, 67, 72, 82, 78, 85, 84, 92, 82, 64, 90, 94, 88, 78, 75, 70, 69, 84, 82, 97, 69, 84, 90, 78, 85, 76, 71, 78, 63, 84, 81, 82, 69, 70, 81, 72]	217.0	205.02	181.0	226.0	[200, 205, 203, 196, 192, 204, 213, 203, 222, 199, 202, 209, 215, 206, 204, 218, 216, 211, 216, 211, 193, 205, 192, 197, 194, 194, 203, 191, 207, 225, 198, 212, 213, 197, 214, 197, 195, 204, 195, 196, 197, 214, 204, 201, 209, 206, 207, 211, 215, 204, 221, 182, 203, 194, 213, 225, 217, 213, 221, 213, 194, 194, 213, 200, 205, 216, 214, 209, 194, 213, 194, 197, 204, 214, 198, 196, 197, 201, 208, 216, 214, 212, 210, 198, 203, 191, 181, 221, 195, 205, 226, 207, 214, 196, 189, 191, 203, 220, 203, 209]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change
SBS36	C>A	Intergenic	['Panc-Endocrine']	1	['Panc-Endocrine']	1	['Panc-Endocrine']	1	[]	0	[]	0	[]	0	['Panc-Endocrine']	1	1.3
SBS36	C>T	Intergenic	['Panc-Endocrine']	1	['Panc-Endocrine']	1	['Panc-Endocrine']	1	[]	0	[]	0	[]	0	['Panc-Endocrine']	1	1.3