# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 32.528 E:A[C>A]A 35.862 A:A[C>G]A 3.613 E:A[C>G]A 3.867 A:A[C>T]A 16.771 E:A[C>T]A 17.961 A:A[T>A]A 495.453 E:A[T>A]A 517.203 A:A[T>C]A 22.659 E:A[T>C]A 21.835 A:A[T>G]A 23.011 E:A[T>G]A 22.692 A:A[C>A]C 52.221 E:A[C>A]C 55.12 A:A[C>G]C 5.042 E:A[C>G]C 5.445 A:A[C>T]C 17.573 E:A[C>T]C 18.345 A:A[T>A]C 255.904 E:A[T>A]C 279.843 A:A[T>C]C 6.257 E:A[T>C]C 5.971 A:A[T>G]C 3.001 E:A[T>G]C 3.112 A:A[C>A]G 0.363 E:A[C>A]G 0.386 A:A[C>G]G 0.0 E:A[C>G]G 0.0 A:A[C>T]G 0.635 E:A[C>T]G 0.652 A:A[T>A]G 168.615 E:A[T>A]G 168.653 A:A[T>C]G 0.082 E:A[T>C]G 0.079 A:A[T>G]G 0.811 E:A[T>G]G 0.795 A:A[C>A]T 9.546 E:A[C>A]T 9.514 A:A[C>G]T 8.988 E:A[C>G]T 9.025 A:A[C>T]T 17.973 E:A[C>T]T 18.11 A:A[T>A]T 1571.402 E:A[T>A]T 1716.577 A:A[T>C]T 10.436 E:A[T>C]T 10.252 A:A[T>G]T 9.694 E:A[T>G]T 9.047 A:C[C>A]A 21.132 E:C[C>A]A 19.312 A:C[C>G]A 0.44 E:C[C>G]A 0.455 A:C[C>T]A 29.451 E:C[C>T]A 30.071 A:C[T>A]A 130.915 E:C[T>A]A 134.222 A:C[T>C]A 3.437 E:C[T>C]A 3.282 A:C[T>G]A 8.541 E:C[T>G]A 8.589 A:C[C>A]C 0.233 E:C[C>A]C 0.224 A:C[C>G]C 0.369 E:C[C>G]C 0.37 A:C[C>T]C 3.441 E:C[C>T]C 3.559 A:C[T>A]C 3.033 E:C[T>A]C 3.151 A:C[T>C]C 0.235 E:C[T>C]C 0.224 A:C[T>G]C 0.0 E:C[T>G]C 0.0 A:C[C>A]G 1.609 E:C[C>A]G 1.38 A:C[C>G]G 0.978 E:C[C>G]G 0.911 A:C[C>T]G 47.804 E:C[C>T]G 47.871 A:C[T>A]G 8.262 E:C[T>A]G 8.197 A:C[T>C]G 4.103 E:C[T>C]G 3.718 A:C[T>G]G 2.496 E:C[T>G]G 2.353 A:C[C>A]T 5.139 E:C[C>A]T 4.817 A:C[C>G]T 0.296 E:C[C>G]T 0.275 A:C[C>T]T 0.225 E:C[C>T]T 0.221 A:C[T>A]T 2.512 E:C[T>A]T 2.494 A:C[T>C]T 10.033 E:C[T>C]T 9.49 A:C[T>G]T 0.006 E:C[T>G]T 0.006 A:G[C>A]A 17.077 E:G[C>A]A 17.389 A:G[C>G]A 0.137 E:G[C>G]A 0.135 A:G[C>T]A 1.188 E:G[C>T]A 1.243 A:G[T>A]A 98.356 E:G[T>A]A 95.44 A:G[T>C]A 0.712 E:G[T>C]A 0.657 A:G[T>G]A 1.879 E:G[T>G]A 1.908 A:G[C>A]C 2.734 E:G[C>A]C 2.707 A:G[C>G]C 0.928 E:G[C>G]C 1.004 A:G[C>T]C 0.0 E:G[C>T]C 0.0 A:G[T>A]C 20.619 E:G[T>A]C 20.676 A:G[T>C]C 4.517 E:G[T>C]C 4.238 A:G[T>G]C 0.0 E:G[T>G]C 0.0 A:G[C>A]G 1.2 E:G[C>A]G 1.302 A:G[C>G]G 0.0 E:G[C>G]G 0.0 A:G[C>T]G 99.676 E:G[C>T]G 101.067 A:G[T>A]G 48.802 E:G[T>A]G 46.961 A:G[T>C]G 2.204 E:G[T>C]G 1.98 A:G[T>G]G 0.249 E:G[T>G]G 0.226 A:G[C>A]T 0.088 E:G[C>A]T 0.083 A:G[C>G]T 0.115 E:G[C>G]T 0.109 A:G[C>T]T 2.951 E:G[C>T]T 2.879 A:G[T>A]T 57.831 E:G[T>A]T 58.678 A:G[T>C]T 0.0 E:G[T>C]T 0.0 A:G[T>G]T 5.148 E:G[T>G]T 4.78 A:T[C>A]A 25.982 E:T[C>A]A 26.746 A:T[C>G]A 0.003 E:T[C>G]A 0.003 A:T[C>T]A 12.398 E:T[C>T]A 12.323 A:T[T>A]A 1360.033 E:T[T>A]A 1346.069 A:T[T>C]A 8.019 E:T[T>C]A 7.609 A:T[T>G]A 0.0 E:T[T>G]A 0.0 A:T[C>A]C 8.047 E:T[C>A]C 7.865 A:T[C>G]C 0.614 E:T[C>G]C 0.598 A:T[C>T]C 1.974 E:T[C>T]C 1.924 A:T[T>A]C 0.0 E:T[T>A]C 0.0 A:T[T>C]C 46.44 E:T[T>C]C 43.902 A:T[T>G]C 0.0 E:T[T>G]C 0.0 A:T[C>A]G 0.0 E:T[C>A]G 0.0 A:T[C>G]G 0.0 E:T[C>G]G 0.0 A:T[C>T]G 1.73 E:T[C>T]G 1.684 A:T[T>A]G 44.074 E:T[T>A]G 40.628 A:T[T>C]G 5.987 E:T[T>C]G 5.302 A:T[T>G]G 11.954 E:T[T>G]G 11.51 A:T[C>A]T 0.248 E:T[C>A]T 0.238 A:T[C>G]T 13.373 E:T[C>G]T 12.423 A:T[C>T]T 5.889 E:T[C>T]T 5.542 A:T[T>A]T 376.303 E:T[T>A]T 367.651 A:T[T>C]T 49.625 E:T[T>C]T 44.617 A:T[T>G]T 1.768 E:T[T>G]T 1.623 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Breast-Cancer SBS34 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS34 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS34 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS34 T>A 3099.0 3378.0 3321.58 3239.64 0.0015208207052315144 0.006140333972783617 100.0 6477.0 Leading 1.09 0.975 1.118 1 3099.0 3321.58 3197.0 3435.0 [3363, 3330, 3353, 3359, 3318, 3222, 3298, 3340, 3280, 3376, 3316, 3273, 3331, 3338, 3346, 3290, 3397, 3314, 3291, 3197, 3410, 3330, 3350, 3314, 3357, 3246, 3323, 3303, 3329, 3378, 3346, 3303, 3234, 3339, 3309, 3233, 3314, 3304, 3305, 3312, 3301, 3267, 3300, 3343, 3303, 3300, 3334, 3365, 3324, 3279, 3345, 3359, 3290, 3251, 3336, 3220, 3350, 3327, 3427, 3350, 3410, 3346, 3300, 3280, 3274, 3310, 3365, 3245, 3314, 3384, 3365, 3293, 3339, 3346, 3331, 3268, 3293, 3323, 3317, 3305, 3366, 3323, 3296, 3381, 3345, 3332, 3323, 3347, 3435, 3324, 3292, 3331, 3303, 3349, 3328, 3343, 3333, 3310, 3285, 3362] 3378.0 3239.64 3137.0 3339.0 [3232, 3232, 3199, 3215, 3252, 3262, 3261, 3248, 3243, 3200, 3229, 3278, 3242, 3262, 3206, 3257, 3226, 3264, 3233, 3321, 3137, 3194, 3212, 3239, 3178, 3295, 3263, 3285, 3212, 3177, 3230, 3277, 3269, 3228, 3278, 3339, 3257, 3262, 3242, 3276, 3237, 3270, 3222, 3170, 3248, 3283, 3231, 3186, 3237, 3267, 3214, 3192, 3274, 3310, 3243, 3334, 3232, 3245, 3143, 3223, 3180, 3222, 3237, 3246, 3302, 3301, 3207, 3293, 3256, 3261, 3200, 3246, 3245, 3209, 3252, 3260, 3275, 3228, 3268, 3241, 3250, 3269, 3242, 3142, 3187, 3223, 3235, 3236, 3141, 3260, 3290, 3233, 3279, 3209, 3243, 3204, 3180, 3254, 3287, 3198] Breast-Cancer SBS34 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS34 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS34 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2869.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS34 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2869.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS34 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2869.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS34 T>A 1343.0 1526.0 1460.79 1439.16 0.007207581887077099 0.026705863247822394 100.0 2869.0 Leading 1.136 0.985 1.153 1 1343.0 1460.79 1396.0 1535.0 [1397, 1508, 1481, 1465, 1452, 1484, 1490, 1512, 1440, 1442, 1501, 1476, 1423, 1433, 1523, 1472, 1466, 1427, 1451, 1437, 1448, 1519, 1461, 1437, 1446, 1461, 1460, 1447, 1494, 1450, 1471, 1427, 1422, 1459, 1462, 1437, 1503, 1423, 1496, 1503, 1471, 1459, 1509, 1454, 1438, 1484, 1469, 1464, 1432, 1431, 1468, 1526, 1478, 1413, 1431, 1455, 1470, 1452, 1508, 1461, 1451, 1484, 1467, 1446, 1446, 1421, 1464, 1494, 1468, 1500, 1523, 1535, 1437, 1452, 1478, 1450, 1467, 1454, 1449, 1466, 1469, 1475, 1431, 1452, 1430, 1465, 1420, 1396, 1441, 1430, 1449, 1488, 1417, 1421, 1499, 1435, 1471, 1445, 1475, 1439] 1526.0 1439.16 1356.0 1519.0 [1505, 1414, 1452, 1443, 1437, 1412, 1401, 1356, 1467, 1452, 1412, 1432, 1519, 1455, 1377, 1436, 1430, 1462, 1455, 1454, 1434, 1381, 1453, 1466, 1449, 1426, 1426, 1477, 1397, 1451, 1437, 1470, 1468, 1397, 1442, 1453, 1429, 1492, 1384, 1402, 1428, 1448, 1420, 1454, 1444, 1436, 1447, 1427, 1443, 1494, 1436, 1384, 1423, 1478, 1446, 1463, 1440, 1435, 1376, 1439, 1465, 1407, 1422, 1489, 1441, 1503, 1454, 1423, 1454, 1412, 1400, 1374, 1428, 1437, 1402, 1431, 1425, 1410, 1451, 1451, 1413, 1421, 1454, 1449, 1485, 1443, 1487, 1481, 1414, 1472, 1459, 1417, 1482, 1461, 1406, 1464, 1420, 1456, 1423, 1464] Panc-AdenoCA SBS34 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2869.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS34 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2869.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS34 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3136.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS34 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3136.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS34 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3136.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS34 T>A 1528.0 1608.0 1586.43 1556.49 0.16515644505658245 0.42749266733496066 100.0 3136.0 Leading 1.052 0.981 1.073 1528.0 1586.43 1516.0 1672.0 [1609, 1543, 1594, 1574, 1580, 1520, 1631, 1607, 1603, 1672, 1543, 1609, 1550, 1609, 1546, 1599, 1630, 1582, 1571, 1592, 1584, 1611, 1596, 1591, 1617, 1561, 1597, 1562, 1576, 1587, 1634, 1645, 1602, 1615, 1586, 1651, 1587, 1589, 1570, 1550, 1555, 1594, 1605, 1548, 1611, 1564, 1572, 1595, 1620, 1566, 1620, 1557, 1575, 1579, 1614, 1562, 1604, 1578, 1609, 1622, 1603, 1570, 1592, 1593, 1597, 1593, 1555, 1637, 1557, 1547, 1582, 1583, 1570, 1630, 1561, 1554, 1566, 1561, 1596, 1557, 1572, 1602, 1627, 1615, 1547, 1553, 1623, 1580, 1527, 1581, 1567, 1612, 1597, 1516, 1523, 1587, 1589, 1581, 1626, 1589] 1608.0 1556.49 1442.0 1614.0 [1517, 1614, 1576, 1590, 1560, 1598, 1495, 1512, 1550, 1442, 1580, 1516, 1566, 1544, 1589, 1562, 1550, 1545, 1592, 1548, 1578, 1561, 1553, 1551, 1555, 1581, 1550, 1583, 1551, 1562, 1527, 1478, 1519, 1506, 1551, 1501, 1559, 1520, 1554, 1592, 1597, 1564, 1539, 1556, 1527, 1555, 1563, 1519, 1517, 1589, 1525, 1574, 1564, 1553, 1537, 1613, 1535, 1563, 1535, 1528, 1570, 1589, 1552, 1549, 1544, 1570, 1576, 1490, 1607, 1611, 1560, 1556, 1591, 1538, 1591, 1581, 1609, 1590, 1523, 1598, 1538, 1552, 1532, 1539, 1596, 1595, 1522, 1561, 1600, 1556, 1568, 1535, 1569, 1612, 1598, 1568, 1555, 1572, 1550, 1505] Stomach-AdenoCA SBS34 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3136.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS34 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3136.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS34 T>A Leading ['Breast-Cancer', 'Panc-AdenoCA'] 2 [] 0 [] 0 [] 0 [] 0 [] 0 ['Breast-Cancer', 'Panc-AdenoCA', 'Stomach-AdenoCA'] 3 1.1