# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on transcribed:T, untranscribed:U, bitranscribed:B and nontranscribed:N strands averaged across cancer types. MutationType Across_All_Cancer_Types T:A[C>A]A 7.0 U:A[C>A]A 5.0 B:A[C>A]A 0.0 N:A[C>A]A 38.0 T:A[C>A]C 4.0 U:A[C>A]C 3.5 B:A[C>A]C 0.0 N:A[C>A]C 18.0 T:A[C>A]G 1.0 U:A[C>A]G 1.0 B:A[C>A]G 0.0 N:A[C>A]G 2.0 T:A[C>A]T 5.0 U:A[C>A]T 4.5 B:A[C>A]T 0.0 N:A[C>A]T 24.5 T:A[C>G]A 2.0 U:A[C>G]A 1.0 B:A[C>G]A 0.0 N:A[C>G]A 10.5 T:A[C>G]C 2.5 U:A[C>G]C 0.5 B:A[C>G]C 0.0 N:A[C>G]C 9.5 T:A[C>G]G 0.5 U:A[C>G]G 0.5 B:A[C>G]G 0.0 N:A[C>G]G 2.0 T:A[C>G]T 1.5 U:A[C>G]T 1.0 B:A[C>G]T 0.0 N:A[C>G]T 10.0 T:A[C>T]A 5.5 U:A[C>T]A 5.0 B:A[C>T]A 0.0 N:A[C>T]A 28.5 T:A[C>T]C 2.5 U:A[C>T]C 1.5 B:A[C>T]C 0.0 N:A[C>T]C 10.0 T:A[C>T]G 15.0 U:A[C>T]G 13.5 B:A[C>T]G 0.0 N:A[C>T]G 41.5 T:A[C>T]T 3.5 U:A[C>T]T 3.0 B:A[C>T]T 0.0 N:A[C>T]T 18.0 T:A[T>A]A 0.5 U:A[T>A]A 0.0 B:A[T>A]A 0.0 N:A[T>A]A 5.5 T:A[T>A]C 0.0 U:A[T>A]C 0.0 B:A[T>A]C 0.0 N:A[T>A]C 5.5 T:A[T>A]G 0.5 U:A[T>A]G 0.5 B:A[T>A]G 0.0 N:A[T>A]G 2.5 T:A[T>A]T 19.5 U:A[T>A]T 14.5 B:A[T>A]T 0.0 N:A[T>A]T 79.0 T:A[T>C]A 17.5 U:A[T>C]A 8.5 B:A[T>C]A 0.0 N:A[T>C]A 54.0 T:A[T>C]C 3.0 U:A[T>C]C 1.5 B:A[T>C]C 0.0 N:A[T>C]C 17.5 T:A[T>C]G 105.5 U:A[T>C]G 111.0 B:A[T>C]G 0.5 N:A[T>C]G 498.5 T:A[T>C]T 11.5 U:A[T>C]T 10.0 B:A[T>C]T 0.0 N:A[T>C]T 41.0 T:A[T>G]A 0.5 U:A[T>G]A 1.0 B:A[T>G]A 0.0 N:A[T>G]A 6.5 T:A[T>G]C 0.0 U:A[T>G]C 0.0 B:A[T>G]C 0.0 N:A[T>G]C 0.5 T:A[T>G]G 0.0 U:A[T>G]G 0.5 B:A[T>G]G 0.0 N:A[T>G]G 1.0 T:A[T>G]T 0.0 U:A[T>G]T 1.5 B:A[T>G]T 0.0 N:A[T>G]T 5.5 T:C[C>A]A 7.5 U:C[C>A]A 8.0 B:C[C>A]A 0.0 N:C[C>A]A 42.0 T:C[C>A]C 3.0 U:C[C>A]C 2.0 B:C[C>A]C 0.0 N:C[C>A]C 18.5 T:C[C>A]G 0.5 U:C[C>A]G 0.5 B:C[C>A]G 0.0 N:C[C>A]G 2.0 T:C[C>A]T 7.0 U:C[C>A]T 7.0 B:C[C>A]T 0.0 N:C[C>A]T 41.0 T:C[C>G]A 0.5 U:C[C>G]A 0.0 B:C[C>G]A 0.0 N:C[C>G]A 7.5 T:C[C>G]C 0.0 U:C[C>G]C 0.0 B:C[C>G]C 0.0 N:C[C>G]C 1.0 T:C[C>G]G 0.0 U:C[C>G]G 0.0 B:C[C>G]G 0.0 N:C[C>G]G 1.5 T:C[C>G]T 0.0 U:C[C>G]T 0.5 B:C[C>G]T 0.0 N:C[C>G]T 2.5 T:C[C>T]A 9.5 U:C[C>T]A 9.0 B:C[C>T]A 0.0 N:C[C>T]A 44.0 T:C[C>T]C 2.0 U:C[C>T]C 2.5 B:C[C>T]C 0.0 N:C[C>T]C 11.5 T:C[C>T]G 15.0 U:C[C>T]G 13.5 B:C[C>T]G 0.0 N:C[C>T]G 35.5 T:C[C>T]T 4.0 U:C[C>T]T 4.0 B:C[C>T]T 0.0 N:C[C>T]T 18.0 T:C[T>A]A 1.0 U:C[T>A]A 1.0 B:C[T>A]A 0.0 N:C[T>A]A 9.0 T:C[T>A]C 1.5 U:C[T>A]C 0.5 B:C[T>A]C 0.0 N:C[T>A]C 8.0 T:C[T>A]G 0.5 U:C[T>A]G 0.0 B:C[T>A]G 0.0 N:C[T>A]G 2.5 T:C[T>A]T 3.0 U:C[T>A]T 2.0 B:C[T>A]T 0.0 N:C[T>A]T 16.5 T:C[T>C]A 25.0 U:C[T>C]A 19.5 B:C[T>C]A 0.0 N:C[T>C]A 100.5 T:C[T>C]C 54.5 U:C[T>C]C 42.0 B:C[T>C]C 0.0 N:C[T>C]C 221.5 T:C[T>C]G 51.0 U:C[T>C]G 69.5 B:C[T>C]G 0.0 N:C[T>C]G 277.5 T:C[T>C]T 3.0 U:C[T>C]T 2.5 B:C[T>C]T 0.0 N:C[T>C]T 22.0 T:C[T>G]A 2.5 U:C[T>G]A 1.0 B:C[T>G]A 0.0 N:C[T>G]A 11.5 T:C[T>G]C 1.0 U:C[T>G]C 1.0 B:C[T>G]C 0.0 N:C[T>G]C 4.5 T:C[T>G]G 1.0 U:C[T>G]G 1.5 B:C[T>G]G 0.0 N:C[T>G]G 6.0 T:C[T>G]T 0.0 U:C[T>G]T 0.0 B:C[T>G]T 0.0 N:C[T>G]T 1.0 T:G[C>A]A 18.5 U:G[C>A]A 12.5 B:G[C>A]A 0.0 N:G[C>A]A 75.0 T:G[C>A]C 1.0 U:G[C>A]C 1.0 B:G[C>A]C 0.0 N:G[C>A]C 6.5 T:G[C>A]G 0.0 U:G[C>A]G 0.0 B:G[C>A]G 0.0 N:G[C>A]G 1.0 T:G[C>A]T 11.5 U:G[C>A]T 5.0 B:G[C>A]T 0.0 N:G[C>A]T 51.0 T:G[C>G]A 0.5 U:G[C>G]A 0.5 B:G[C>G]A 0.0 N:G[C>G]A 3.0 T:G[C>G]C 0.5 U:G[C>G]C 1.5 B:G[C>G]C 0.0 N:G[C>G]C 3.5 T:G[C>G]G 0.0 U:G[C>G]G 0.0 B:G[C>G]G 0.0 N:G[C>G]G 0.0 T:G[C>G]T 0.5 U:G[C>G]T 0.5 B:G[C>G]T 0.0 N:G[C>G]T 5.0 T:G[C>T]A 11.0 U:G[C>T]A 12.0 B:G[C>T]A 0.0 N:G[C>T]A 43.5 T:G[C>T]C 9.0 U:G[C>T]C 10.0 B:G[C>T]C 0.0 N:G[C>T]C 39.5 T:G[C>T]G 14.0 U:G[C>T]G 13.5 B:G[C>T]G 0.0 N:G[C>T]G 39.0 T:G[C>T]T 6.5 U:G[C>T]T 8.5 B:G[C>T]T 0.0 N:G[C>T]T 35.0 T:G[T>A]A 0.0 U:G[T>A]A 0.5 B:G[T>A]A 0.0 N:G[T>A]A 3.5 T:G[T>A]C 0.0 U:G[T>A]C 0.0 B:G[T>A]C 0.0 N:G[T>A]C 2.0 T:G[T>A]G 1.0 U:G[T>A]G 0.5 B:G[T>A]G 0.0 N:G[T>A]G 3.5 T:G[T>A]T 1.0 U:G[T>A]T 2.5 B:G[T>A]T 0.0 N:G[T>A]T 19.0 T:G[T>C]A 17.0 U:G[T>C]A 17.5 B:G[T>C]A 0.0 N:G[T>C]A 81.0 T:G[T>C]C 14.5 U:G[T>C]C 13.5 B:G[T>C]C 0.0 N:G[T>C]C 60.0 T:G[T>C]G 277.0 U:G[T>C]G 469.5 B:G[T>C]G 1.5 N:G[T>C]G 1453.0 T:G[T>C]T 15.5 U:G[T>C]T 18.5 B:G[T>C]T 0.0 N:G[T>C]T 66.0 T:G[T>G]A 0.0 U:G[T>G]A 0.0 B:G[T>G]A 0.0 N:G[T>G]A 2.5 T:G[T>G]C 1.0 U:G[T>G]C 0.0 B:G[T>G]C 0.0 N:G[T>G]C 2.0 T:G[T>G]G 9.0 U:G[T>G]G 14.0 B:G[T>G]G 0.0 N:G[T>G]G 51.0 T:G[T>G]T 0.5 U:G[T>G]T 0.5 B:G[T>G]T 0.0 N:G[T>G]T 3.5 T:T[C>A]A 23.5 U:T[C>A]A 21.0 B:T[C>A]A 0.0 N:T[C>A]A 99.5 T:T[C>A]C 10.5 U:T[C>A]C 10.0 B:T[C>A]C 0.0 N:T[C>A]C 39.0 T:T[C>A]G 1.0 U:T[C>A]G 1.0 B:T[C>A]G 0.0 N:T[C>A]G 5.5 T:T[C>A]T 31.5 U:T[C>A]T 35.5 B:T[C>A]T 0.0 N:T[C>A]T 169.5 T:T[C>G]A 27.0 U:T[C>G]A 24.5 B:T[C>G]A 0.0 N:T[C>G]A 91.5 T:T[C>G]C 2.5 U:T[C>G]C 2.0 B:T[C>G]C 0.0 N:T[C>G]C 15.0 T:T[C>G]G 0.0 U:T[C>G]G 0.0 B:T[C>G]G 0.0 N:T[C>G]G 0.0 T:T[C>G]T 37.5 U:T[C>G]T 43.5 B:T[C>G]T 0.0 N:T[C>G]T 138.5 T:T[C>T]A 30.0 U:T[C>T]A 30.5 B:T[C>T]A 0.0 N:T[C>T]A 104.5 T:T[C>T]C 4.0 U:T[C>T]C 4.5 B:T[C>T]C 0.0 N:T[C>T]C 22.0 T:T[C>T]G 6.5 U:T[C>T]G 7.5 B:T[C>T]G 0.0 N:T[C>T]G 21.5 T:T[C>T]T 16.0 U:T[C>T]T 16.5 B:T[C>T]T 0.0 N:T[C>T]T 62.5 T:T[T>A]A 9.0 U:T[T>A]A 9.5 B:T[T>A]A 0.0 N:T[T>A]A 42.5 T:T[T>A]C 0.0 U:T[T>A]C 0.0 B:T[T>A]C 0.0 N:T[T>A]C 1.0 T:T[T>A]G 1.0 U:T[T>A]G 0.0 B:T[T>A]G 0.0 N:T[T>A]G 4.0 T:T[T>A]T 4.0 U:T[T>A]T 4.5 B:T[T>A]T 0.0 N:T[T>A]T 29.0 T:T[T>C]A 14.5 U:T[T>C]A 12.5 B:T[T>C]A 0.0 N:T[T>C]A 66.0 T:T[T>C]C 19.0 U:T[T>C]C 22.5 B:T[T>C]C 0.0 N:T[T>C]C 92.5 T:T[T>C]G 417.5 U:T[T>C]G 807.0 B:T[T>C]G 4.5 N:T[T>C]G 2689.5 T:T[T>C]T 13.0 U:T[T>C]T 14.5 B:T[T>C]T 0.0 N:T[T>C]T 56.5 T:T[T>G]A 0.0 U:T[T>G]A 0.5 B:T[T>G]A 0.0 N:T[T>G]A 1.5 T:T[T>G]C 0.0 U:T[T>G]C 0.0 B:T[T>G]C 0.0 N:T[T>G]C 0.0 T:T[T>G]G 0.0 U:T[T>G]G 0.5 B:T[T>G]G 0.0 N:T[T>G]G 7.5 T:T[T>G]T 2.0 U:T[T>G]T 4.5 B:T[T>G]T 0.0 N:T[T>G]T 20.0 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Transcribed_real_count UnTranscribed_real_count NonTranscribed_real_count Transcribed_mean_sims_count UnTranscribed_mean_sims_count NonTranscribed_mean_sims_count transcribed_versus_untranscribed_p_value transcribed_versus_untranscribed_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Transcribed_real_count.1 Transcribed_mean_sims_count.1 Transcribed_min_sims_count Transcribed_max_sims_count Transcribed_sims_count_list UnTranscribed_real_count.1 UnTranscribed_mean_sims_count.1 UnTranscribed_min_sims_count UnTranscribed_max_sims_count UnTranscribed_sims_count_list NonTranscribed_real_count.1 NonTranscribed_mean_sims_count.1 NonTranscribed_min_sims_count NonTranscribed_max_sims_count NonTranscribed_sims_count_list ESCC SBS33 C>A 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 14621.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS33 C>G 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 14621.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS33 C>T 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 14621.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS33 T>A 22.0 11.0 70.0 19.61 22.24 60.52 0.10198532411165123 0.2895819466798419 0.704 14621.0 Transcribed 2.0 0.882 2.268 1 1 1 1 1 1 22.0 19.61 11.0 30.0 [14, 19, 26, 12, 17, 16, 17, 27, 24, 14, 17, 21, 19, 23, 19, 13, 27, 22, 18, 23, 20, 27, 19, 21, 24, 19, 13, 14, 17, 16, 21, 19, 24, 23, 23, 23, 15, 19, 14, 13, 15, 18, 17, 21, 12, 23, 17, 17, 18, 17, 21, 17, 22, 20, 23, 15, 13, 14, 21, 19, 22, 21, 17, 27, 15, 17, 16, 22, 20, 21, 27, 21, 22, 15, 19, 16, 20, 30, 12, 21, 16, 18, 21, 25, 22, 17, 22, 27, 28, 20, 11, 20, 20, 17, 28, 27, 21, 19, 26, 23] 11.0 22.24 12.0 35.0 [27, 18, 14, 33, 27, 22, 32, 20, 20, 27, 21, 20, 21, 23, 24, 23, 14, 15, 24, 16, 23, 16, 14, 23, 15, 24, 29, 29, 24, 18, 26, 16, 17, 22, 16, 24, 21, 22, 19, 19, 19, 19, 18, 22, 33, 31, 25, 21, 19, 22, 22, 18, 17, 25, 28, 24, 26, 30, 14, 35, 23, 24, 26, 19, 23, 20, 19, 20, 24, 20, 18, 24, 20, 24, 21, 28, 24, 22, 24, 24, 27, 32, 16, 24, 22, 29, 29, 12, 18, 14, 31, 22, 26, 31, 21, 13, 22, 25, 17, 20] 70.0 60.52 48.0 70.0 [62, 65, 63, 58, 58, 64, 53, 56, 58, 62, 64, 62, 62, 57, 59, 66, 61, 65, 60, 63, 61, 59, 69, 58, 63, 59, 61, 59, 61, 68, 55, 67, 61, 58, 63, 55, 68, 61, 69, 70, 69, 65, 67, 59, 57, 49, 62, 64, 66, 64, 59, 67, 63, 58, 52, 63, 64, 58, 67, 48, 57, 58, 59, 57, 65, 65, 67, 60, 58, 61, 57, 57, 61, 63, 62, 59, 59, 52, 67, 58, 59, 52, 65, 54, 58, 56, 52, 64, 56, 68, 60, 60, 56, 54, 54, 62, 60, 58, 59, 59] ESCC SBS33 T>C 1751.0 2918.0 9739.0 2779.07 3365.79 8303.89 6.960409256982372e-16 5.289817418504222e-15 98.543 14621.0 Untranscribed 1.666 1.211 1.376 1 1 1 1751.0 2779.07 2660.0 2923.0 [2769, 2823, 2771, 2796, 2786, 2774, 2827, 2784, 2831, 2782, 2745, 2705, 2751, 2786, 2702, 2813, 2788, 2792, 2808, 2760, 2860, 2796, 2811, 2770, 2752, 2826, 2718, 2731, 2795, 2804, 2777, 2746, 2769, 2743, 2772, 2682, 2867, 2811, 2848, 2783, 2720, 2849, 2746, 2801, 2806, 2803, 2825, 2729, 2749, 2680, 2762, 2910, 2746, 2770, 2846, 2838, 2861, 2751, 2822, 2731, 2860, 2775, 2755, 2816, 2856, 2848, 2781, 2807, 2671, 2730, 2809, 2786, 2778, 2737, 2747, 2780, 2808, 2755, 2811, 2739, 2692, 2803, 2735, 2744, 2778, 2764, 2795, 2774, 2763, 2923, 2758, 2725, 2802, 2751, 2731, 2777, 2660, 2771, 2729, 2784] 2918.0 3365.79 3225.0 3513.0 [3381, 3225, 3292, 3341, 3362, 3352, 3304, 3362, 3409, 3324, 3377, 3422, 3410, 3368, 3352, 3367, 3335, 3258, 3394, 3376, 3371, 3327, 3345, 3401, 3390, 3380, 3513, 3388, 3392, 3404, 3403, 3295, 3261, 3408, 3419, 3368, 3383, 3348, 3354, 3317, 3443, 3341, 3413, 3376, 3332, 3270, 3409, 3356, 3439, 3430, 3359, 3352, 3378, 3300, 3284, 3320, 3302, 3396, 3320, 3349, 3297, 3432, 3464, 3345, 3283, 3377, 3368, 3304, 3428, 3378, 3365, 3375, 3398, 3424, 3313, 3345, 3364, 3384, 3312, 3314, 3427, 3361, 3416, 3408, 3489, 3322, 3349, 3308, 3441, 3343, 3459, 3362, 3423, 3366, 3467, 3391, 3309, 3406, 3285, 3330] 9739.0 8303.89 8180.0 8474.0 [8304, 8408, 8390, 8309, 8303, 8324, 8314, 8293, 8201, 8340, 8319, 8323, 8283, 8294, 8397, 8263, 8334, 8404, 8256, 8299, 8224, 8335, 8282, 8272, 8314, 8250, 8226, 8330, 8252, 8245, 8275, 8405, 8416, 8293, 8265, 8408, 8202, 8301, 8259, 8351, 8284, 8258, 8289, 8269, 8300, 8384, 8214, 8362, 8265, 8330, 8324, 8182, 8328, 8374, 8309, 8292, 8289, 8311, 8305, 8362, 8289, 8226, 8240, 8293, 8307, 8218, 8297, 8327, 8356, 8344, 8266, 8291, 8267, 8294, 8384, 8329, 8282, 8316, 8322, 8390, 8326, 8281, 8290, 8303, 8189, 8358, 8305, 8367, 8262, 8180, 8235, 8368, 8230, 8321, 8254, 8276, 8474, 8273, 8430, 8335] ESCC SBS33 T>G 17.0 20.0 73.0 21.7 25.57 63.2 1.0 1.0 0.752 14621.0 Untranscribed 1.176 1.178 0.998 17.0 21.7 12.0 33.0 [22, 15, 25, 17, 16, 20, 22, 21, 29, 17, 22, 29, 21, 24, 19, 30, 16, 15, 20, 26, 25, 20, 16, 23, 12, 26, 20, 30, 19, 26, 29, 25, 16, 20, 22, 25, 23, 21, 22, 22, 30, 12, 21, 19, 21, 22, 24, 21, 13, 19, 23, 14, 29, 25, 25, 25, 19, 24, 25, 25, 23, 18, 23, 15, 18, 27, 27, 23, 31, 19, 18, 23, 19, 19, 20, 21, 17, 20, 22, 22, 21, 24, 23, 16, 27, 33, 16, 19, 26, 25, 16, 23, 21, 19, 19, 23, 22, 21, 22, 25] 20.0 25.57 14.0 39.0 [27, 21, 22, 34, 17, 28, 20, 22, 23, 29, 24, 30, 26, 26, 33, 22, 17, 22, 24, 21, 26, 24, 31, 21, 32, 24, 35, 20, 28, 29, 23, 19, 25, 28, 24, 27, 27, 22, 30, 30, 26, 31, 31, 25, 25, 20, 17, 32, 34, 31, 23, 29, 25, 28, 30, 26, 26, 28, 28, 23, 23, 30, 18, 27, 24, 14, 22, 20, 21, 22, 39, 19, 26, 27, 26, 18, 28, 27, 26, 26, 25, 30, 23, 27, 25, 25, 26, 31, 26, 23, 30, 20, 29, 25, 26, 28, 23, 31, 29, 21] 73.0 63.2 51.0 77.0 [62, 75, 63, 60, 77, 64, 68, 67, 59, 64, 65, 51, 63, 60, 58, 61, 77, 74, 67, 63, 60, 66, 63, 66, 66, 60, 56, 64, 63, 56, 58, 66, 69, 63, 64, 58, 60, 67, 58, 59, 54, 69, 58, 66, 64, 68, 69, 59, 63, 60, 64, 68, 57, 58, 55, 59, 65, 58, 58, 63, 64, 62, 69, 69, 68, 69, 62, 67, 59, 69, 54, 68, 65, 64, 64, 71, 65, 63, 63, 62, 64, 58, 64, 67, 58, 55, 68, 61, 58, 63, 65, 68, 60, 67, 65, 59, 65, 59, 60, 64] Head-SCC SBS33 C>A 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2480.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS33 C>G 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2480.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS33 C>T 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2480.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS33 T>A 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2480.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS33 T>C 297.0 496.0 1687.0 487.06 576.61 1417.47 0.00030818563763725093 0.0013410881366725349 100.0 2480.0 Untranscribed 1.67 1.184 1.411 1 1 1 297.0 487.06 428.0 534.0 [490, 467, 482, 509, 518, 495, 470, 484, 463, 495, 487, 469, 462, 493, 471, 448, 464, 489, 481, 446, 500, 479, 484, 472, 497, 488, 510, 493, 490, 464, 460, 481, 505, 500, 462, 481, 484, 502, 467, 482, 480, 469, 490, 497, 503, 498, 486, 496, 510, 468, 527, 464, 487, 470, 517, 498, 463, 493, 486, 497, 474, 500, 483, 488, 522, 483, 487, 477, 492, 472, 504, 481, 507, 507, 491, 515, 503, 483, 507, 503, 488, 501, 480, 462, 513, 448, 498, 500, 485, 482, 480, 478, 534, 516, 428, 515, 483, 482, 496, 475] 496.0 576.61 524.0 646.0 [562, 570, 586, 574, 539, 596, 579, 566, 563, 589, 566, 591, 582, 571, 553, 607, 609, 572, 585, 578, 566, 557, 576, 590, 569, 626, 550, 527, 569, 606, 597, 572, 593, 549, 572, 562, 604, 609, 584, 566, 605, 563, 559, 561, 556, 572, 596, 565, 558, 534, 552, 564, 607, 600, 550, 536, 553, 614, 561, 580, 597, 610, 584, 547, 591, 646, 587, 566, 587, 572, 577, 564, 591, 608, 600, 559, 524, 584, 536, 576, 570, 578, 609, 596, 557, 594, 536, 571, 590, 580, 600, 589, 553, 604, 555, 564, 597, 568, 602, 574] 1687.0 1417.47 1346.0 1497.0 [1436, 1442, 1411, 1400, 1422, 1387, 1437, 1433, 1450, 1405, 1433, 1422, 1439, 1422, 1455, 1423, 1407, 1421, 1416, 1457, 1411, 1447, 1426, 1419, 1414, 1369, 1431, 1458, 1419, 1411, 1426, 1427, 1383, 1431, 1448, 1437, 1392, 1371, 1426, 1436, 1395, 1444, 1427, 1426, 1419, 1415, 1400, 1416, 1413, 1473, 1405, 1453, 1392, 1409, 1408, 1445, 1462, 1375, 1434, 1408, 1417, 1373, 1407, 1443, 1368, 1346, 1403, 1437, 1402, 1441, 1397, 1438, 1384, 1363, 1393, 1408, 1453, 1408, 1440, 1397, 1419, 1406, 1399, 1416, 1414, 1441, 1452, 1413, 1404, 1417, 1398, 1418, 1393, 1361, 1497, 1402, 1404, 1427, 1397, 1432] Head-SCC SBS33 T>G 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2480.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS33 T>C Untranscribed ['ESCC', 'Head-SCC'] 2 ['ESCC', 'Head-SCC'] 2 ['ESCC', 'Head-SCC'] 2 [] 0 [] 0 [] 0 ['ESCC', 'Head-SCC'] 2 1.3