# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 12.854 E:A[C>A]A 14.396 A:A[C>G]A 0.794 E:A[C>G]A 0.993 A:A[C>T]A 105.618 E:A[C>T]A 117.738 A:A[T>A]A 1.192 E:A[T>A]A 1.71 A:A[T>C]A 0.574 E:A[T>C]A 0.563 A:A[T>G]A 0.487 E:A[T>G]A 0.649 A:A[C>A]C 9.439 E:A[C>A]C 11.537 A:A[C>G]C 1.156 E:A[C>G]C 1.982 A:A[C>T]C 90.009 E:A[C>T]C 103.431 A:A[T>A]C 1.311 E:A[T>A]C 1.114 A:A[T>C]C 0.479 E:A[T>C]C 0.423 A:A[T>G]C 0.257 E:A[T>G]C 0.171 A:A[C>A]G 2.312 E:A[C>A]G 1.734 A:A[C>G]G 0.0 E:A[C>G]G 0.0 A:A[C>T]G 34.383 E:A[C>T]G 37.976 A:A[T>A]G 0.675 E:A[T>A]G 0.844 A:A[T>C]G 0.787 E:A[T>C]G 0.707 A:A[T>G]G 0.587 E:A[T>G]G 0.419 A:A[C>A]T 12.149 E:A[C>A]T 11.045 A:A[C>G]T 0.807 E:A[C>G]T 0.987 A:A[C>T]T 152.983 E:A[C>T]T 149.041 A:A[T>A]T 1.736 E:A[T>A]T 2.893 A:A[T>C]T 0.462 E:A[T>C]T 0.435 A:A[T>G]T 0.0 E:A[T>G]T 0.0 A:C[C>A]A 2.271 E:C[C>A]A 2.271 A:C[C>G]A 0.607 E:C[C>G]A 0.693 A:C[C>T]A 47.861 E:C[C>T]A 44.561 A:C[T>A]A 0.6 E:C[T>A]A 0.8 A:C[T>C]A 0.549 E:C[T>C]A 0.673 A:C[T>G]A 0.14 E:C[T>G]A 0.127 A:C[C>A]C 4.902 E:C[C>A]C 5.822 A:C[C>G]C 0.198 E:C[C>G]C 0.446 A:C[C>T]C 26.371 E:C[C>T]C 25.446 A:C[T>A]C 1.196 E:C[T>A]C 0.864 A:C[T>C]C 0.751 E:C[T>C]C 0.939 A:C[T>G]C 0.211 E:C[T>G]C 0.317 A:C[C>A]G 0.014 E:C[C>A]G 0.014 A:C[C>G]G 0.325 E:C[C>G]G 0.325 A:C[C>T]G 11.371 E:C[C>T]G 9.436 A:C[T>A]G 2.207 E:C[T>A]G 1.793 A:C[T>C]G 1.111 E:C[T>C]G 1.111 A:C[T>G]G 0.461 E:C[T>G]G 0.554 A:C[C>A]T 2.488 E:C[C>A]T 3.828 A:C[C>G]T 0.29 E:C[C>G]T 0.348 A:C[C>T]T 64.453 E:C[C>T]T 52.078 A:C[T>A]T 1.051 E:C[T>A]T 0.97 A:C[T>C]T 0.445 E:C[T>C]T 0.891 A:C[T>G]T 1.008 E:C[T>G]T 0.554 A:G[C>A]A 3.989 E:G[C>A]A 3.79 A:G[C>G]A 0.583 E:G[C>G]A 0.583 A:G[C>T]A 36.162 E:G[C>T]A 36.555 A:G[T>A]A 5.208 E:G[T>A]A 4.05 A:G[T>C]A 8.602 E:G[T>C]A 6.72 A:G[T>G]A 0.414 E:G[T>G]A 0.414 A:G[C>A]C 4.896 E:G[C>A]C 2.768 A:G[C>G]C 0.46 E:G[C>G]C 0.552 A:G[C>T]C 54.66 E:G[C>T]C 59.674 A:G[T>A]C 6.177 E:G[T>A]C 6.177 A:G[T>C]C 4.535 E:G[T>C]C 2.791 A:G[T>G]C 0.599 E:G[T>G]C 0.399 A:G[C>A]G 0.516 E:G[C>A]G 0.516 A:G[C>G]G 0.025 E:G[C>G]G 0.0 A:G[C>T]G 10.804 E:G[C>T]G 12.448 A:G[T>A]G 8.379 E:G[T>A]G 9.023 A:G[T>C]G 8.027 E:G[T>C]G 6.957 A:G[T>G]G 1.712 E:G[T>G]G 1.467 A:G[C>A]T 2.809 E:G[C>A]T 3.673 A:G[C>G]T 0.096 E:G[C>G]T 0.134 A:G[C>T]T 41.679 E:G[C>T]T 41.679 A:G[T>A]T 4.168 E:G[T>A]T 5.731 A:G[T>C]T 11.577 E:G[T>C]T 9.823 A:G[T>G]T 0.322 E:G[T>G]T 0.965 A:T[C>A]A 14.128 E:T[C>A]A 12.05 A:T[C>G]A 0.0 E:T[C>G]A 0.0 A:T[C>T]A 38.145 E:T[C>T]A 36.914 A:T[T>A]A 1.277 E:T[T>A]A 0.658 A:T[T>C]A 1.363 E:T[T>C]A 1.14 A:T[T>G]A 0.017 E:T[T>G]A 0.02 A:T[C>A]C 10.767 E:T[C>A]C 13.279 A:T[C>G]C 0.997 E:T[C>G]C 1.228 A:T[C>T]C 34.453 E:T[C>T]C 35.438 A:T[T>A]C 2.285 E:T[T>A]C 2.793 A:T[T>C]C 1.673 E:T[T>C]C 1.673 A:T[T>G]C 0.193 E:T[T>G]C 0.154 A:T[C>A]G 2.61 E:T[C>A]G 1.491 A:T[C>G]G 0.749 E:T[C>G]G 0.999 A:T[C>T]G 9.97 E:T[C>T]G 8.333 A:T[T>A]G 1.92 E:T[T>A]G 1.222 A:T[T>C]G 2.048 E:T[T>C]G 2.26 A:T[T>G]G 0.376 E:T[T>G]G 0.502 A:T[C>A]T 10.664 E:T[C>A]T 9.141 A:T[C>G]T 1.094 E:T[C>G]T 0.881 A:T[C>T]T 47.193 E:T[C>T]T 43.961 A:T[T>A]T 0.688 E:T[T>A]T 0.688 A:T[T>C]T 0.824 E:T[T>C]T 0.844 A:T[T>G]T 0.553 E:T[T>G]T 0.632 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Biliary-AdenoCA SBS32 C>A 69.0 83.0 72.62 77.21 0.64489408365415 1.0 7.669 1982.0 Leading 1.203 1.063 1.131 1 69.0 72.62 59.0 85.0 [73.0, 63.0, 77.0, 75.0, 78.0, 77.0, 64.0, 75.0, 66.0, 71.0, 65.0, 72.0, 77.0, 82.0, 71.0, 69.0, 65.0, 64.0, 79.0, 64.0, 59.0, 82.0, 74.0, 75.0, 79.0, 68.0, 68.0, 85.0, 75.0, 71.0, 77.0, 68.0, 72.0, 72.0, 79.0, 71.0, 76.0, 71.0, 77.0, 73.0, 79.0, 78.0, 71.0, 71.0, 70.0, 76.0, 73.0, 71.0, 75.0, 80.0, 75.0, 68.0, 72.0, 75.0, 76.0, 61.0, 67.0, 66.0, 82.0, 69.0, 65.0, 80.0, 74.0, 78.0, 78.0, 74.0, 82.0, 75.0, 66.0, 79.0, 71.0, 77.0, 71.0, 84.0, 70.0, 71.0, 84.0, 74.0, 68.0, 66.0, 64.0, 77.0, 73.0, 63.0, 79.0, 70.0, 69.0, 74.0, 66.0, 72.0, 68.0, 77.0, 74.0, 69.0, 64.0, 70.0, 74.0, 80.0, 65.0, 73.0] 83.0 77.21 67.0 91.0 [73.0, 83.0, 79.0, 82.0, 73.0, 76.0, 84.0, 73.0, 80.0, 83.0, 87.0, 74.0, 68.0, 67.0, 80.0, 78.0, 81.0, 81.0, 73.0, 86.0, 85.0, 68.0, 78.0, 79.0, 74.0, 76.0, 79.0, 70.0, 79.0, 78.0, 72.0, 83.0, 81.0, 80.0, 72.0, 83.0, 77.0, 74.0, 75.0, 76.0, 73.0, 71.0, 81.0, 77.0, 81.0, 73.0, 76.0, 79.0, 74.0, 68.0, 72.0, 80.0, 74.0, 78.0, 78.0, 83.0, 80.0, 82.0, 67.0, 83.0, 89.0, 68.0, 78.0, 75.0, 70.0, 71.0, 70.0, 82.0, 91.0, 69.0, 83.0, 71.0, 77.0, 69.0, 75.0, 80.0, 69.0, 79.0, 82.0, 87.0, 87.0, 73.0, 80.0, 80.0, 73.0, 76.0, 83.0, 73.0, 75.0, 82.0, 82.0, 72.0, 74.0, 75.0, 86.0, 78.0, 76.0, 72.0, 83.0, 76.0] Biliary-AdenoCA SBS32 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1982.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS32 C>T 865.0 882.0 861.23 880.55 1.0 1.0 88.143 1982.0 Leading 1.02 1.022 0.997 865.0 861.23 816.0 925.0 [864.0, 865.0, 851.0, 854.0, 874.0, 900.0, 904.0, 885.0, 832.0, 887.0, 883.0, 842.0, 873.0, 853.0, 859.0, 880.0, 834.0, 905.0, 816.0, 837.0, 891.0, 830.0, 880.0, 847.0, 876.0, 869.0, 854.0, 833.0, 869.0, 855.0, 855.0, 856.0, 890.0, 861.0, 854.0, 888.0, 860.0, 863.0, 892.0, 866.0, 868.0, 866.0, 868.0, 863.0, 873.0, 854.0, 865.0, 862.0, 891.0, 854.0, 925.0, 858.0, 865.0, 835.0, 856.0, 872.0, 872.0, 903.0, 835.0, 860.0, 864.0, 831.0, 872.0, 855.0, 848.0, 841.0, 872.0, 818.0, 877.0, 872.0, 880.0, 862.0, 860.0, 908.0, 826.0, 862.0, 869.0, 869.0, 867.0, 816.0, 818.0, 863.0, 840.0, 837.0, 857.0, 858.0, 860.0, 853.0, 857.0, 853.0, 842.0, 865.0, 847.0, 843.0, 849.0, 830.0, 889.0, 872.0, 870.0, 819.0] 882.0 880.55 815.0 955.0 [879.0, 887.0, 886.0, 892.0, 865.0, 841.0, 830.0, 863.0, 904.0, 863.0, 845.0, 896.0, 871.0, 905.0, 894.0, 865.0, 902.0, 849.0, 908.0, 911.0, 844.0, 911.0, 863.0, 899.0, 861.0, 875.0, 873.0, 907.0, 875.0, 893.0, 886.0, 894.0, 841.0, 866.0, 886.0, 844.0, 878.0, 878.0, 857.0, 888.0, 885.0, 875.0, 887.0, 885.0, 869.0, 874.0, 890.0, 882.0, 868.0, 876.0, 815.0, 882.0, 864.0, 878.0, 894.0, 864.0, 890.0, 845.0, 910.0, 878.0, 892.0, 901.0, 864.0, 892.0, 908.0, 885.0, 875.0, 917.0, 861.0, 861.0, 867.0, 884.0, 877.0, 820.0, 910.0, 865.0, 867.0, 883.0, 861.0, 955.0, 907.0, 872.0, 904.0, 930.0, 871.0, 874.0, 879.0, 881.0, 871.0, 907.0, 924.0, 898.0, 898.0, 869.0, 887.0, 903.0, 877.0, 891.0, 861.0, 920.0] Biliary-AdenoCA SBS32 T>A 40.0 43.0 41.75 40.2 0.8759418963839561 1.0 4.188 1982.0 Leading 1.075 0.963 1.116 1 40.0 41.75 30.0 54.0 [41.0, 44.0, 42.0, 34.0, 47.0, 42.0, 42.0, 44.0, 47.0, 36.0, 43.0, 38.0, 39.0, 41.0, 44.0, 37.0, 48.0, 43.0, 42.0, 37.0, 47.0, 43.0, 45.0, 39.0, 40.0, 39.0, 43.0, 40.0, 44.0, 41.0, 42.0, 38.0, 33.0, 42.0, 34.0, 33.0, 51.0, 38.0, 42.0, 41.0, 45.0, 45.0, 46.0, 40.0, 43.0, 38.0, 44.0, 40.0, 40.0, 42.0, 41.0, 47.0, 44.0, 50.0, 43.0, 37.0, 30.0, 42.0, 43.0, 38.0, 42.0, 48.0, 44.0, 43.0, 38.0, 47.0, 39.0, 47.0, 45.0, 44.0, 40.0, 37.0, 38.0, 50.0, 42.0, 39.0, 54.0, 41.0, 34.0, 44.0, 48.0, 47.0, 35.0, 46.0, 46.0, 43.0, 45.0, 41.0, 37.0, 40.0, 41.0, 39.0, 45.0, 38.0, 43.0, 42.0, 41.0, 37.0, 35.0, 46.0] 43.0 40.2 28.0 51.0 [42.0, 34.0, 36.0, 46.0, 35.0, 41.0, 41.0, 41.0, 35.0, 49.0, 41.0, 43.0, 46.0, 42.0, 39.0, 47.0, 36.0, 41.0, 35.0, 44.0, 36.0, 41.0, 36.0, 44.0, 44.0, 39.0, 38.0, 40.0, 38.0, 40.0, 42.0, 44.0, 45.0, 37.0, 45.0, 50.0, 29.0, 47.0, 40.0, 43.0, 36.0, 38.0, 42.0, 44.0, 42.0, 43.0, 35.0, 45.0, 41.0, 42.0, 39.0, 32.0, 34.0, 32.0, 37.0, 41.0, 51.0, 38.0, 40.0, 46.0, 41.0, 35.0, 37.0, 38.0, 43.0, 37.0, 46.0, 36.0, 41.0, 35.0, 42.0, 41.0, 44.0, 35.0, 36.0, 44.0, 28.0, 41.0, 46.0, 33.0, 36.0, 38.0, 48.0, 42.0, 35.0, 33.0, 40.0, 37.0, 45.0, 45.0, 43.0, 46.0, 33.0, 44.0, 43.0, 42.0, 45.0, 39.0, 41.0, 36.0] Biliary-AdenoCA SBS32 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1982.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS32 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 1982.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change