# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types. MutationType Across_All_Cancer_Types T:A[C>A]A 6.0 U:A[C>A]A 4.0 B:A[C>A]A 0.0 N:A[C>A]A 17.0 T:A[C>A]C 5.0 U:A[C>A]C 5.0 B:A[C>A]C 0.0 N:A[C>A]C 17.0 T:A[C>A]G 1.0 U:A[C>A]G 1.0 B:A[C>A]G 0.0 N:A[C>A]G 5.0 T:A[C>A]T 2.0 U:A[C>A]T 2.0 B:A[C>A]T 0.0 N:A[C>A]T 17.0 T:A[C>G]A 0.0 U:A[C>G]A 0.0 B:A[C>G]A 0.0 N:A[C>G]A 1.0 T:A[C>G]C 0.0 U:A[C>G]C 0.0 B:A[C>G]C 0.0 N:A[C>G]C 2.0 T:A[C>G]G 0.0 U:A[C>G]G 0.0 B:A[C>G]G 0.0 N:A[C>G]G 0.0 T:A[C>G]T 0.0 U:A[C>G]T 0.0 B:A[C>G]T 0.0 N:A[C>G]T 1.0 T:A[C>T]A 64.0 U:A[C>T]A 29.0 B:A[C>T]A 1.0 N:A[C>T]A 149.0 T:A[C>T]C 56.0 U:A[C>T]C 24.0 B:A[C>T]C 0.0 N:A[C>T]C 136.0 T:A[C>T]G 14.0 U:A[C>T]G 10.0 B:A[C>T]G 0.0 N:A[C>T]G 49.0 T:A[C>T]T 77.0 U:A[C>T]T 52.0 B:A[C>T]T 3.0 N:A[C>T]T 194.0 T:A[T>A]A 0.0 U:A[T>A]A 0.0 B:A[T>A]A 0.0 N:A[T>A]A 1.0 T:A[T>A]C 0.0 U:A[T>A]C 0.0 B:A[T>A]C 0.0 N:A[T>A]C 1.0 T:A[T>A]G 0.0 U:A[T>A]G 0.0 B:A[T>A]G 0.0 N:A[T>A]G 1.0 T:A[T>A]T 0.0 U:A[T>A]T 1.0 B:A[T>A]T 0.0 N:A[T>A]T 3.0 T:A[T>C]A 0.0 U:A[T>C]A 0.0 B:A[T>C]A 0.0 N:A[T>C]A 0.0 T:A[T>C]C 0.0 U:A[T>C]C 0.0 B:A[T>C]C 0.0 N:A[T>C]C 0.0 T:A[T>C]G 0.0 U:A[T>C]G 0.0 B:A[T>C]G 0.0 N:A[T>C]G 1.0 T:A[T>C]T 0.0 U:A[T>C]T 0.0 B:A[T>C]T 0.0 N:A[T>C]T 0.0 T:A[T>G]A 0.0 U:A[T>G]A 0.0 B:A[T>G]A 0.0 N:A[T>G]A 0.0 T:A[T>G]C 0.0 U:A[T>G]C 0.0 B:A[T>G]C 0.0 N:A[T>G]C 0.0 T:A[T>G]G 0.0 U:A[T>G]G 0.0 B:A[T>G]G 0.0 N:A[T>G]G 0.0 T:A[T>G]T 0.0 U:A[T>G]T 0.0 B:A[T>G]T 0.0 N:A[T>G]T 0.0 T:C[C>A]A 1.0 U:C[C>A]A 0.0 B:C[C>A]A 0.0 N:C[C>A]A 3.0 T:C[C>A]C 1.0 U:C[C>A]C 0.0 B:C[C>A]C 0.0 N:C[C>A]C 9.0 T:C[C>A]G 0.0 U:C[C>A]G 0.0 B:C[C>A]G 0.0 N:C[C>A]G 0.0 T:C[C>A]T 0.0 U:C[C>A]T 1.0 B:C[C>A]T 0.0 N:C[C>A]T 5.0 T:C[C>G]A 0.0 U:C[C>G]A 0.0 B:C[C>G]A 0.0 N:C[C>G]A 0.0 T:C[C>G]C 0.0 U:C[C>G]C 0.0 B:C[C>G]C 0.0 N:C[C>G]C 0.0 T:C[C>G]G 0.0 U:C[C>G]G 0.0 B:C[C>G]G 0.0 N:C[C>G]G 0.0 T:C[C>G]T 0.0 U:C[C>G]T 0.0 B:C[C>G]T 0.0 N:C[C>G]T 0.0 T:C[C>T]A 22.0 U:C[C>T]A 13.0 B:C[C>T]A 0.0 N:C[C>T]A 65.0 T:C[C>T]C 12.0 U:C[C>T]C 10.0 B:C[C>T]C 0.0 N:C[C>T]C 33.0 T:C[C>T]G 4.0 U:C[C>T]G 4.0 B:C[C>T]G 0.0 N:C[C>T]G 13.0 T:C[C>T]T 20.0 U:C[C>T]T 21.0 B:C[C>T]T 0.0 N:C[C>T]T 79.0 T:C[T>A]A 0.0 U:C[T>A]A 0.0 B:C[T>A]A 0.0 N:C[T>A]A 1.0 T:C[T>A]C 0.0 U:C[T>A]C 0.0 B:C[T>A]C 0.0 N:C[T>A]C 1.0 T:C[T>A]G 0.0 U:C[T>A]G 0.0 B:C[T>A]G 0.0 N:C[T>A]G 2.0 T:C[T>A]T 0.0 U:C[T>A]T 0.0 B:C[T>A]T 0.0 N:C[T>A]T 1.0 T:C[T>C]A 0.0 U:C[T>C]A 0.0 B:C[T>C]A 0.0 N:C[T>C]A 1.0 T:C[T>C]C 0.0 U:C[T>C]C 0.0 B:C[T>C]C 0.0 N:C[T>C]C 0.0 T:C[T>C]G 0.0 U:C[T>C]G 0.0 B:C[T>C]G 0.0 N:C[T>C]G 1.0 T:C[T>C]T 0.0 U:C[T>C]T 0.0 B:C[T>C]T 0.0 N:C[T>C]T 1.0 T:C[T>G]A 0.0 U:C[T>G]A 0.0 B:C[T>G]A 0.0 N:C[T>G]A 0.0 T:C[T>G]C 0.0 U:C[T>G]C 0.0 B:C[T>G]C 0.0 N:C[T>G]C 0.0 T:C[T>G]G 0.0 U:C[T>G]G 0.0 B:C[T>G]G 0.0 N:C[T>G]G 0.0 T:C[T>G]T 0.0 U:C[T>G]T 0.0 B:C[T>G]T 0.0 N:C[T>G]T 0.0 T:G[C>A]A 1.0 U:G[C>A]A 1.0 B:G[C>A]A 0.0 N:G[C>A]A 5.0 T:G[C>A]C 1.0 U:G[C>A]C 1.0 B:G[C>A]C 0.0 N:G[C>A]C 5.0 T:G[C>A]G 0.0 U:G[C>A]G 0.0 B:G[C>A]G 0.0 N:G[C>A]G 0.0 T:G[C>A]T 1.0 U:G[C>A]T 1.0 B:G[C>A]T 0.0 N:G[C>A]T 3.0 T:G[C>G]A 0.0 U:G[C>G]A 0.0 B:G[C>G]A 0.0 N:G[C>G]A 1.0 T:G[C>G]C 0.0 U:G[C>G]C 0.0 B:G[C>G]C 0.0 N:G[C>G]C 0.0 T:G[C>G]G 0.0 U:G[C>G]G 0.0 B:G[C>G]G 0.0 N:G[C>G]G 0.0 T:G[C>G]T 0.0 U:G[C>G]T 0.0 B:G[C>G]T 0.0 N:G[C>G]T 0.0 T:G[C>T]A 18.0 U:G[C>T]A 9.0 B:G[C>T]A 0.0 N:G[C>T]A 51.0 T:G[C>T]C 30.0 U:G[C>T]C 21.0 B:G[C>T]C 1.0 N:G[C>T]C 76.0 T:G[C>T]G 4.0 U:G[C>T]G 6.0 B:G[C>T]G 0.0 N:G[C>T]G 16.0 T:G[C>T]T 18.0 U:G[C>T]T 12.0 B:G[C>T]T 0.0 N:G[C>T]T 59.0 T:G[T>A]A 1.0 U:G[T>A]A 2.0 B:G[T>A]A 0.0 N:G[T>A]A 5.0 T:G[T>A]C 3.0 U:G[T>A]C 4.0 B:G[T>A]C 0.0 N:G[T>A]C 7.0 T:G[T>A]G 1.0 U:G[T>A]G 1.0 B:G[T>A]G 0.0 N:G[T>A]G 12.0 T:G[T>A]T 0.0 U:G[T>A]T 1.0 B:G[T>A]T 0.0 N:G[T>A]T 9.0 T:G[T>C]A 4.0 U:G[T>C]A 1.0 B:G[T>C]A 0.0 N:G[T>C]A 12.0 T:G[T>C]C 1.0 U:G[T>C]C 1.0 B:G[T>C]C 0.0 N:G[T>C]C 5.0 T:G[T>C]G 4.0 U:G[T>C]G 2.0 B:G[T>C]G 0.0 N:G[T>C]G 7.0 T:G[T>C]T 2.0 U:G[T>C]T 3.0 B:G[T>C]T 0.0 N:G[T>C]T 16.0 T:G[T>G]A 0.0 U:G[T>G]A 0.0 B:G[T>G]A 0.0 N:G[T>G]A 1.0 T:G[T>G]C 0.0 U:G[T>G]C 0.0 B:G[T>G]C 0.0 N:G[T>G]C 0.0 T:G[T>G]G 0.0 U:G[T>G]G 0.0 B:G[T>G]G 0.0 N:G[T>G]G 2.0 T:G[T>G]T 0.0 U:G[T>G]T 0.0 B:G[T>G]T 0.0 N:G[T>G]T 1.0 T:T[C>A]A 5.0 U:T[C>A]A 2.0 B:T[C>A]A 0.0 N:T[C>A]A 19.0 T:T[C>A]C 5.0 U:T[C>A]C 3.0 B:T[C>A]C 0.0 N:T[C>A]C 22.0 T:T[C>A]G 0.0 U:T[C>A]G 1.0 B:T[C>A]G 0.0 N:T[C>A]G 1.0 T:T[C>A]T 7.0 U:T[C>A]T 4.0 B:T[C>A]T 0.0 N:T[C>A]T 11.0 T:T[C>G]A 0.0 U:T[C>G]A 0.0 B:T[C>G]A 0.0 N:T[C>G]A 0.0 T:T[C>G]C 0.0 U:T[C>G]C 0.0 B:T[C>G]C 0.0 N:T[C>G]C 0.0 T:T[C>G]G 0.0 U:T[C>G]G 0.0 B:T[C>G]G 0.0 N:T[C>G]G 0.0 T:T[C>G]T 0.0 U:T[C>G]T 0.0 B:T[C>G]T 0.0 N:T[C>G]T 1.0 T:T[C>T]A 13.0 U:T[C>T]A 18.0 B:T[C>T]A 0.0 N:T[C>T]A 46.0 T:T[C>T]C 21.0 U:T[C>T]C 16.0 B:T[C>T]C 0.0 N:T[C>T]C 38.0 T:T[C>T]G 3.0 U:T[C>T]G 3.0 B:T[C>T]G 0.0 N:T[C>T]G 10.0 T:T[C>T]T 18.0 U:T[C>T]T 21.0 B:T[C>T]T 1.0 N:T[C>T]T 53.0 T:T[T>A]A 0.0 U:T[T>A]A 0.0 B:T[T>A]A 0.0 N:T[T>A]A 1.0 T:T[T>A]C 1.0 U:T[T>A]C 1.0 B:T[T>A]C 0.0 N:T[T>A]C 3.0 T:T[T>A]G 0.0 U:T[T>A]G 0.0 B:T[T>A]G 0.0 N:T[T>A]G 2.0 T:T[T>A]T 0.0 U:T[T>A]T 0.0 B:T[T>A]T 0.0 N:T[T>A]T 0.0 T:T[T>C]A 0.0 U:T[T>C]A 0.0 B:T[T>C]A 0.0 N:T[T>C]A 1.0 T:T[T>C]C 0.0 U:T[T>C]C 0.0 B:T[T>C]C 0.0 N:T[T>C]C 2.0 T:T[T>C]G 0.0 U:T[T>C]G 0.0 B:T[T>C]G 0.0 N:T[T>C]G 3.0 T:T[T>C]T 0.0 U:T[T>C]T 0.0 B:T[T>C]T 0.0 N:T[T>C]T 0.0 T:T[T>G]A 0.0 U:T[T>G]A 0.0 B:T[T>G]A 0.0 N:T[T>G]A 0.0 T:T[T>G]C 0.0 U:T[T>G]C 0.0 B:T[T>G]C 0.0 N:T[T>G]C 0.0 T:T[T>G]G 0.0 U:T[T>G]G 0.0 B:T[T>G]G 0.0 N:T[T>G]G 0.0 T:T[T>G]T 0.0 U:T[T>G]T 0.0 B:T[T>G]T 0.0 N:T[T>G]T 0.0 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type genic_real_count intergenic_real_count genic_mean_sims_count intergenic_mean_sims_count genic_versus_intergenic_p_value genic_versus_intergenic_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Transcribed_real_count Transcribed_mean_sims_count Transcribed_min_sims_count Transcribed_max_sims_count Transcribed_sims_count_list UnTranscribed_real_count UnTranscribed_mean_sims_count UnTranscribed_min_sims_count UnTranscribed_max_sims_count UnTranscribed_sims_count_list NonTranscribed_real_count NonTranscribed_mean_sims_count NonTranscribed_min_sims_count NonTranscribed_max_sims_count NonTranscribed_sims_count_list Biliary-AdenoCA SBS32 C>A 54.0 110.0 72.55 92.3 0.05342229439345858 0.16636135269784388 7.554 2171.0 Intergenic 2.037 1.272 1.601 1 1 1 1 29.0 37.72 27.0 53.0 [35.0, 31.0, 33.0, 41.0, 33.0, 41.0, 45.0, 36.0, 37.0, 31.0, 33.0, 33.0, 38.0, 42.0, 39.0, 30.0, 35.0, 35.0, 44.0, 42.0, 34.0, 42.0, 39.0, 43.0, 44.0, 34.0, 38.0, 37.0, 42.0, 37.0, 48.0, 53.0, 37.0, 39.0, 32.0, 34.0, 38.0, 34.0, 38.0, 39.0, 47.0, 38.0, 39.0, 34.0, 30.0, 32.0, 48.0, 27.0, 33.0, 40.0, 37.0, 44.0, 42.0, 34.0, 31.0, 52.0, 42.0, 38.0, 49.0, 36.0, 30.0, 43.0, 34.0, 41.0, 33.0, 42.0, 34.0, 37.0, 30.0, 29.0, 34.0, 34.0, 39.0, 41.0, 29.0, 40.0, 34.0, 44.0, 31.0, 40.0, 36.0, 35.0, 33.0, 40.0, 35.0, 36.0, 49.0, 49.0, 38.0, 45.0, 40.0, 43.0, 37.0, 38.0, 30.0, 46.0, 32.0, 28.0, 36.0, 38.0] 25.0 34.83 23.0 45.0 [37.0, 41.0, 31.0, 32.0, 32.0, 40.0, 30.0, 34.0, 37.0, 41.0, 33.0, 37.0, 37.0, 32.0, 35.0, 36.0, 32.0, 36.0, 40.0, 40.0, 30.0, 26.0, 33.0, 33.0, 29.0, 36.0, 31.0, 41.0, 23.0, 45.0, 33.0, 26.0, 32.0, 37.0, 34.0, 32.0, 45.0, 30.0, 34.0, 37.0, 26.0, 27.0, 30.0, 42.0, 34.0, 41.0, 34.0, 38.0, 35.0, 40.0, 41.0, 35.0, 30.0, 29.0, 37.0, 31.0, 30.0, 39.0, 34.0, 45.0, 32.0, 38.0, 31.0, 36.0, 34.0, 36.0, 37.0, 35.0, 32.0, 36.0, 41.0, 24.0, 41.0, 34.0, 25.0, 32.0, 30.0, 38.0, 39.0, 39.0, 43.0, 35.0, 36.0, 34.0, 33.0, 32.0, 27.0, 29.0, 36.0, 36.0, 39.0, 33.0, 40.0, 28.0, 38.0, 42.0, 35.0, 39.0, 42.0, 38.0] 110.0 92.3 77.0 110.0 [92.0, 92.0, 101.0, 92.0, 100.0, 84.0, 90.0, 95.0, 90.0, 92.0, 101.0, 96.0, 89.0, 90.0, 91.0, 99.0, 99.0, 93.0, 82.0, 85.0, 102.0, 98.0, 93.0, 88.0, 91.0, 94.0, 95.0, 86.0, 99.0, 84.0, 84.0, 85.0, 95.0, 88.0, 98.0, 98.0, 82.0, 100.0, 92.0, 88.0, 92.0, 100.0, 97.0, 90.0, 100.0, 92.0, 82.0, 100.0, 96.0, 84.0, 87.0, 86.0, 93.0, 102.0, 96.0, 83.0, 93.0, 87.0, 83.0, 85.0, 103.0, 84.0, 100.0, 90.0, 98.0, 87.0, 94.0, 93.0, 102.0, 100.0, 90.0, 106.0, 86.0, 89.0, 110.0, 93.0, 100.0, 82.0, 95.0, 87.0, 85.0, 95.0, 95.0, 92.0, 98.0, 96.0, 88.0, 87.0, 91.0, 84.0, 85.0, 89.0, 90.0, 100.0, 96.0, 77.0, 97.0, 98.0, 87.0, 90.0] Biliary-AdenoCA SBS32 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2171.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS32 C>T 752.0 1165.0 833.88 1079.42 0.006479877410442861 0.02420796516212059 88.3 2171.0 Intergenic 1.549 1.294 1.197 1 1 453.0 429.56 378.0 470.0 [453.0, 437.0, 442.0, 420.0, 418.0, 405.0, 467.0, 438.0, 411.0, 427.0, 428.0, 419.0, 408.0, 452.0, 445.0, 431.0, 450.0, 446.0, 406.0, 417.0, 427.0, 426.0, 440.0, 424.0, 454.0, 432.0, 429.0, 428.0, 441.0, 426.0, 426.0, 443.0, 433.0, 434.0, 427.0, 460.0, 429.0, 378.0, 425.0, 412.0, 447.0, 435.0, 463.0, 425.0, 399.0, 417.0, 425.0, 413.0, 412.0, 448.0, 412.0, 463.0, 419.0, 395.0, 407.0, 448.0, 463.0, 432.0, 424.0, 401.0, 423.0, 428.0, 435.0, 433.0, 459.0, 431.0, 403.0, 463.0, 436.0, 428.0, 470.0, 398.0, 434.0, 412.0, 401.0, 436.0, 405.0, 423.0, 429.0, 393.0, 441.0, 417.0, 413.0, 425.0, 437.0, 440.0, 412.0, 437.0, 430.0, 455.0, 444.0, 434.0, 433.0, 419.0, 430.0, 461.0, 438.0, 431.0, 432.0, 425.0] 299.0 404.32 365.0 441.0 [379.0, 432.0, 437.0, 419.0, 381.0, 400.0, 376.0, 419.0, 422.0, 425.0, 391.0, 412.0, 408.0, 416.0, 410.0, 385.0, 389.0, 401.0, 407.0, 406.0, 438.0, 441.0, 419.0, 365.0, 411.0, 405.0, 380.0, 378.0, 394.0, 390.0, 381.0, 407.0, 417.0, 406.0, 397.0, 404.0, 411.0, 418.0, 395.0, 408.0, 374.0, 402.0, 406.0, 413.0, 439.0, 407.0, 388.0, 421.0, 428.0, 394.0, 403.0, 426.0, 440.0, 416.0, 415.0, 408.0, 378.0, 408.0, 427.0, 415.0, 411.0, 401.0, 422.0, 392.0, 381.0, 403.0, 407.0, 375.0, 399.0, 397.0, 393.0, 402.0, 414.0, 415.0, 440.0, 376.0, 434.0, 403.0, 407.0, 381.0, 391.0, 407.0, 410.0, 390.0, 367.0, 375.0, 425.0, 409.0, 414.0, 380.0, 373.0, 399.0, 422.0, 386.0, 399.0, 377.0, 422.0, 421.0, 427.0, 397.0] 1165.0 1079.42 1031.0 1140.0 [1084.0, 1045.0, 1034.0, 1075.0, 1110.0, 1109.0, 1073.0, 1063.0, 1081.0, 1063.0, 1090.0, 1080.0, 1101.0, 1044.0, 1057.0, 1091.0, 1075.0, 1062.0, 1101.0, 1092.0, 1053.0, 1051.0, 1049.0, 1121.0, 1047.0, 1076.0, 1105.0, 1104.0, 1074.0, 1095.0, 1102.0, 1063.0, 1059.0, 1074.0, 1091.0, 1050.0, 1073.0, 1121.0, 1091.0, 1091.0, 1092.0, 1078.0, 1047.0, 1079.0, 1074.0, 1088.0, 1101.0, 1077.0, 1073.0, 1070.0, 1099.0, 1031.0, 1059.0, 1098.0, 1087.0, 1059.0, 1071.0, 1075.0, 1063.0, 1094.0, 1076.0, 1087.0, 1056.0, 1088.0, 1072.0, 1079.0, 1099.0, 1085.0, 1081.0, 1084.0, 1053.0, 1115.0, 1063.0, 1083.0, 1073.0, 1102.0, 1072.0, 1090.0, 1075.0, 1140.0, 1083.0, 1088.0, 1087.0, 1100.0, 1114.0, 1098.0, 1071.0, 1070.0, 1073.0, 1082.0, 1096.0, 1084.0, 1060.0, 1107.0, 1088.0, 1073.0, 1057.0, 1062.0, 1049.0, 1092.0] Biliary-AdenoCA SBS32 T>A 29.0 61.0 39.46 51.15 0.1662601119098223 0.4293875151751154 4.146 2171.0 Intergenic 2.103 1.296 1.623 1 1 1 1 11.0 18.29 10.0 26.0 [12.0, 18.0, 20.0, 16.0, 22.0, 17.0, 17.0, 16.0, 20.0, 19.0, 15.0, 25.0, 12.0, 21.0, 21.0, 16.0, 14.0, 20.0, 21.0, 25.0, 19.0, 18.0, 17.0, 11.0, 16.0, 13.0, 22.0, 14.0, 15.0, 21.0, 24.0, 19.0, 16.0, 22.0, 17.0, 14.0, 26.0, 15.0, 20.0, 24.0, 16.0, 18.0, 17.0, 18.0, 19.0, 24.0, 19.0, 21.0, 15.0, 16.0, 22.0, 22.0, 23.0, 25.0, 15.0, 11.0, 14.0, 18.0, 14.0, 16.0, 20.0, 20.0, 21.0, 18.0, 20.0, 15.0, 20.0, 13.0, 17.0, 23.0, 22.0, 25.0, 18.0, 19.0, 21.0, 14.0, 12.0, 17.0, 12.0, 19.0, 19.0, 23.0, 18.0, 19.0, 18.0, 13.0, 20.0, 22.0, 18.0, 26.0, 19.0, 10.0, 20.0, 17.0, 22.0, 17.0, 20.0, 17.0, 17.0, 15.0] 18.0 21.17 12.0 31.0 [21.0, 23.0, 21.0, 20.0, 21.0, 24.0, 20.0, 25.0, 12.0, 14.0, 19.0, 15.0, 21.0, 21.0, 22.0, 26.0, 19.0, 19.0, 22.0, 13.0, 16.0, 20.0, 19.0, 16.0, 25.0, 22.0, 24.0, 26.0, 31.0, 21.0, 13.0, 19.0, 16.0, 20.0, 17.0, 20.0, 21.0, 25.0, 19.0, 22.0, 23.0, 25.0, 17.0, 17.0, 25.0, 20.0, 21.0, 21.0, 17.0, 22.0, 18.0, 13.0, 19.0, 22.0, 21.0, 21.0, 25.0, 19.0, 18.0, 21.0, 16.0, 23.0, 15.0, 18.0, 23.0, 18.0, 19.0, 24.0, 27.0, 18.0, 23.0, 22.0, 17.0, 24.0, 20.0, 25.0, 25.0, 19.0, 25.0, 27.0, 23.0, 21.0, 27.0, 21.0, 20.0, 30.0, 24.0, 24.0, 22.0, 13.0, 24.0, 25.0, 25.0, 26.0, 27.0, 21.0, 25.0, 25.0, 20.0, 31.0] 61.0 51.15 42.0 65.0 [57.0, 49.0, 49.0, 55.0, 48.0, 49.0, 53.0, 49.0, 59.0, 57.0, 56.0, 51.0, 57.0, 49.0, 48.0, 49.0, 57.0, 52.0, 47.0, 54.0, 55.0, 53.0, 54.0, 65.0, 50.0, 55.0, 45.0, 50.0, 44.0, 49.0, 55.0, 52.0, 58.0, 48.0, 57.0, 58.0, 43.0, 50.0, 51.0, 44.0, 51.0, 48.0, 56.0, 56.0, 46.0, 47.0, 52.0, 49.0, 59.0, 52.0, 50.0, 56.0, 49.0, 44.0, 55.0, 58.0, 51.0, 55.0, 60.0, 54.0, 54.0, 49.0, 54.0, 54.0, 49.0, 57.0, 51.0, 54.0, 48.0, 51.0, 45.0, 46.0, 55.0, 47.0, 50.0, 52.0, 53.0, 54.0, 53.0, 45.0, 48.0, 46.0, 45.0, 51.0, 53.0, 48.0, 47.0, 44.0, 51.0, 52.0, 47.0, 55.0, 45.0, 47.0, 42.0, 52.0, 47.0, 48.0, 53.0, 44.0] Biliary-AdenoCA SBS32 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2171.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS32 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2171.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS32 C>T Intergenic ['Biliary-AdenoCA'] 1 ['Biliary-AdenoCA'] 1 [] 0 [] 0 [] 0 [] 0 ['Biliary-AdenoCA'] 1 1.2