# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS30 Bone-Osteosarc [397, 419, 410, 387, 426, 377, 409, 391, 469, 199] [0.772, 0.815, 0.798, 0.754, 0.829, 0.736, 0.799, 0.766, 0.92, 1.0] [0.982, 0.942, 0.921, 0.888, 0.865, 0.858, 0.837, 0.839, 0.836, 0.851] 0.016 0.264 0.123 FLAT 0.5 3897 0.797 SBS30 Breast-Cancer [566, 453, 531, 469, 450, 456, 444, 461, 452, 203] [1.0, 0.8, 0.938, 0.829, 0.795, 0.808, 0.787, 0.82, 0.805, 0.926] [1.0, 0.868, 0.81, 0.783, 0.763, 0.741, 0.72, 0.708, 0.711, 0.675] -0.008 0.213 0.118 FLAT 0.6 4485 0.769 SBS30 ESCC [349, 246, 267, 248, 237, 263, 263, 276, 222, 106] [1.0, 0.705, 0.765, 0.711, 0.679, 0.756, 0.756, 0.796, 0.642, 0.784] [1.0, 0.839, 0.773, 0.726, 0.68, 0.652, 0.619, 0.602, 0.571, 0.576] -0.012 0.358 0.02 FLAT 0.66 2477 0.755 SBS30 ACROSS_ALL_CANCER_TYPES [1.0, 0.837, 0.902, 0.828, 0.831, 0.83, 0.845, 0.859, 0.854, 0.978] [0.994, 0.883, 0.835, 0.799, 0.769, 0.75, 0.726, 0.716, 0.706, 0.7] 0 3 0 3