# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 7.763 E:A[C>A]A 7.839 A:A[C>G]A 4.947 E:A[C>G]A 4.833 A:A[C>T]A 342.625 E:A[C>T]A 353.542 A:A[T>A]A 2.283 E:A[T>A]A 2.329 A:A[T>C]A 1.878 E:A[T>C]A 1.97 A:A[T>G]A 0.238 E:A[T>G]A 0.229 A:A[C>A]C 2.346 E:A[C>A]C 2.424 A:A[C>G]C 2.208 E:A[C>G]C 2.098 A:A[C>T]C 318.851 E:A[C>T]C 328.906 A:A[T>A]C 1.927 E:A[T>A]C 1.892 A:A[T>C]C 1.693 E:A[T>C]C 1.686 A:A[T>G]C 0.531 E:A[T>G]C 0.521 A:A[C>A]G 0.503 E:A[C>A]G 0.527 A:A[C>G]G 1.9 E:A[C>G]G 1.71 A:A[C>T]G 57.395 E:A[C>T]G 55.551 A:A[T>A]G 2.635 E:A[T>A]G 2.73 A:A[T>C]G 0.63 E:A[T>C]G 0.695 A:A[T>G]G 1.367 E:A[T>G]G 1.333 A:A[C>A]T 2.992 E:A[C>A]T 3.031 A:A[C>G]T 2.849 E:A[C>G]T 3.108 A:A[C>T]T 104.957 E:A[C>T]T 104.252 A:A[T>A]T 4.007 E:A[T>A]T 4.344 A:A[T>C]T 1.619 E:A[T>C]T 1.62 A:A[T>G]T 7.46 E:A[T>G]T 7.096 A:C[C>A]A 3.689 E:C[C>A]A 3.934 A:C[C>G]A 4.714 E:C[C>G]A 4.523 A:C[C>T]A 445.281 E:C[C>T]A 460.683 A:C[T>A]A 1.192 E:C[T>A]A 1.242 A:C[T>C]A 5.697 E:C[T>C]A 5.661 A:C[T>G]A 1.107 E:C[T>G]A 1.048 A:C[C>A]C 1.718 E:C[C>A]C 1.664 A:C[C>G]C 2.722 E:C[C>G]C 2.676 A:C[C>T]C 399.302 E:C[C>T]C 394.792 A:C[T>A]C 3.047 E:C[T>A]C 3.049 A:C[T>C]C 5.626 E:C[T>C]C 5.2 A:C[T>G]C 0.67 E:C[T>G]C 0.71 A:C[C>A]G 1.703 E:C[C>A]G 1.401 A:C[C>G]G 0.589 E:C[C>G]G 0.726 A:C[C>T]G 59.196 E:C[C>T]G 57.321 A:C[T>A]G 2.913 E:C[T>A]G 2.749 A:C[T>C]G 4.472 E:C[T>C]G 4.127 A:C[T>G]G 0.251 E:C[T>G]G 0.229 A:C[C>A]T 1.944 E:C[C>A]T 1.889 A:C[C>G]T 3.762 E:C[C>G]T 3.757 A:C[C>T]T 194.31 E:C[C>T]T 189.569 A:C[T>A]T 3.95 E:C[T>A]T 3.498 A:C[T>C]T 15.904 E:C[T>C]T 15.465 A:C[T>G]T 1.659 E:C[T>G]T 1.737 A:G[C>A]A 5.015 E:G[C>A]A 5.41 A:G[C>G]A 1.665 E:G[C>G]A 1.824 A:G[C>T]A 224.673 E:G[C>T]A 227.224 A:G[T>A]A 1.404 E:G[T>A]A 1.383 A:G[T>C]A 4.964 E:G[T>C]A 5.026 A:G[T>G]A 0.625 E:G[T>G]A 0.65 A:G[C>A]C 2.272 E:G[C>A]C 2.341 A:G[C>G]C 0.922 E:G[C>G]C 0.95 A:G[C>T]C 241.786 E:G[C>T]C 237.938 A:G[T>A]C 0.918 E:G[T>A]C 0.872 A:G[T>C]C 2.919 E:G[T>C]C 2.766 A:G[T>G]C 1.038 E:G[T>G]C 1.121 A:G[C>A]G 0.0 E:G[C>A]G 0.0 A:G[C>G]G 0.331 E:G[C>G]G 0.352 A:G[C>T]G 23.928 E:G[C>T]G 22.723 A:G[T>A]G 0.326 E:G[T>A]G 0.329 A:G[T>C]G 1.674 E:G[T>C]G 1.564 A:G[T>G]G 2.83 E:G[T>G]G 3.052 A:G[C>A]T 4.64 E:G[C>A]T 4.146 A:G[C>G]T 1.514 E:G[C>G]T 1.374 A:G[C>T]T 82.849 E:G[C>T]T 81.352 A:G[T>A]T 1.039 E:G[T>A]T 1.001 A:G[T>C]T 2.521 E:G[T>C]T 2.272 A:G[T>G]T 1.061 E:G[T>G]T 1.084 A:T[C>A]A 3.229 E:T[C>A]A 3.236 A:T[C>G]A 0.51 E:T[C>G]A 0.503 A:T[C>T]A 427.698 E:T[C>T]A 397.123 A:T[T>A]A 1.837 E:T[T>A]A 1.838 A:T[T>C]A 2.494 E:T[T>C]A 2.351 A:T[T>G]A 0.624 E:T[T>G]A 0.547 A:T[C>A]C 1.028 E:T[C>A]C 0.999 A:T[C>G]C 3.939 E:T[C>G]C 4.052 A:T[C>T]C 562.539 E:T[C>T]C 536.923 A:T[T>A]C 1.107 E:T[T>A]C 1.105 A:T[T>C]C 1.384 E:T[T>C]C 1.366 A:T[T>G]C 0.281 E:T[T>G]C 0.334 A:T[C>A]G 0.319 E:T[C>A]G 0.253 A:T[C>G]G 0.547 E:T[C>G]G 0.51 A:T[C>T]G 56.905 E:T[C>T]G 52.86 A:T[T>A]G 0.711 E:T[T>A]G 0.753 A:T[T>C]G 0.723 E:T[T>C]G 0.69 A:T[T>G]G 3.342 E:T[T>G]G 3.34 A:T[C>A]T 3.75 E:T[C>A]T 3.499 A:T[C>G]T 0.532 E:T[C>G]T 0.488 A:T[C>T]T 234.801 E:T[C>T]T 218.162 A:T[T>A]T 3.74 E:T[T>A]T 3.62 A:T[T>C]T 1.914 E:T[T>C]T 1.818 A:T[T>G]T 41.381 E:T[T>G]T 38.391 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Bone-Osteosarc SBS30 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3543.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Bone-Osteosarc SBS30 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3543.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Bone-Osteosarc SBS30 C>T 1784.0 1759.0 1759.04 1802.61 0.4335938189591315 0.8569506379953035 100.0 3543.0 Lagging 1.014 0.976 1.039 1784.0 1759.04 1667.0 1858.0 [1753, 1799, 1751, 1750, 1734, 1708, 1783, 1755, 1780, 1792, 1761, 1781, 1764, 1770, 1711, 1716, 1727, 1744, 1789, 1790, 1753, 1768, 1749, 1746, 1779, 1777, 1719, 1731, 1667, 1759, 1765, 1782, 1793, 1740, 1686, 1741, 1785, 1782, 1776, 1723, 1746, 1743, 1758, 1730, 1710, 1816, 1749, 1731, 1775, 1732, 1777, 1750, 1728, 1738, 1770, 1749, 1747, 1825, 1736, 1858, 1790, 1766, 1791, 1770, 1773, 1810, 1753, 1786, 1794, 1755, 1763, 1752, 1667, 1753, 1767, 1772, 1747, 1727, 1750, 1776, 1763, 1807, 1738, 1758, 1791, 1722, 1764, 1730, 1762, 1759, 1761, 1834, 1765, 1817, 1763, 1783, 1722, 1763, 1764, 1729] 1759.0 1802.61 1720.0 1880.0 [1807, 1756, 1806, 1809, 1845, 1851, 1774, 1768, 1787, 1775, 1809, 1785, 1797, 1810, 1832, 1875, 1849, 1822, 1786, 1767, 1814, 1810, 1797, 1784, 1777, 1805, 1835, 1827, 1879, 1801, 1830, 1822, 1787, 1804, 1867, 1786, 1782, 1776, 1824, 1818, 1795, 1795, 1779, 1832, 1839, 1745, 1803, 1880, 1792, 1840, 1778, 1810, 1834, 1830, 1813, 1800, 1825, 1758, 1831, 1720, 1785, 1813, 1800, 1784, 1774, 1734, 1786, 1791, 1748, 1818, 1798, 1796, 1853, 1800, 1786, 1781, 1806, 1828, 1826, 1770, 1837, 1738, 1819, 1789, 1779, 1832, 1783, 1811, 1819, 1825, 1798, 1728, 1812, 1754, 1783, 1774, 1842, 1812, 1790, 1825] Bone-Osteosarc SBS30 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3543.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Bone-Osteosarc SBS30 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3543.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Bone-Osteosarc SBS30 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3543.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS30 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4115.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS30 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4115.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS30 C>T 2021.0 2094.0 2021.84 2084.94 0.92967894144132 1.0 100.0 4115.0 Leading 1.036 1.031 1.005 2021.0 2021.84 1929.0 2139.0 [2033, 2057, 1971, 2139, 2061, 2014, 2010, 2074, 2062, 2013, 2048, 2035, 2048, 2039, 1964, 2008, 2019, 1967, 1985, 2022, 2040, 2078, 2096, 1980, 2015, 2044, 2055, 2043, 2037, 2014, 2040, 2005, 2038, 2000, 2017, 2030, 1985, 1970, 2037, 1998, 2045, 1981, 1976, 2050, 2043, 2038, 2072, 2015, 2036, 1988, 2023, 2018, 2028, 1929, 1989, 1972, 2013, 2007, 2000, 2030, 1981, 1968, 1989, 2010, 2059, 2082, 1997, 2006, 1997, 2085, 2026, 2014, 2071, 2036, 2066, 2068, 2041, 1989, 2074, 2011, 2046, 2060, 1980, 2004, 1970, 1978, 1997, 2011, 2011, 2089, 2016, 1965, 2014, 1951, 2047, 2059, 2033, 2017, 2032, 1990] 2094.0 2084.94 1978.0 2182.0 [2045, 2023, 2109, 1978, 2031, 2105, 2092, 2029, 2038, 2094, 2054, 2069, 2071, 2052, 2141, 2085, 2100, 2133, 2123, 2095, 2087, 2016, 2035, 2141, 2097, 2053, 2056, 2105, 2084, 2110, 2086, 2095, 2094, 2098, 2103, 2090, 2063, 2142, 2081, 2089, 2066, 2128, 2123, 2048, 2081, 2104, 2047, 2092, 2056, 2112, 2076, 2088, 2067, 2147, 2113, 2126, 2075, 2084, 2080, 2088, 2137, 2159, 2132, 2074, 2036, 2014, 2122, 2093, 2110, 2066, 2077, 2100, 2043, 2075, 2057, 2064, 2051, 2078, 2048, 2083, 2062, 2065, 2108, 2108, 2109, 2141, 2103, 2109, 2128, 2016, 2066, 2126, 2068, 2182, 2062, 2040, 2081, 2096, 2082, 2130] Breast-Cancer SBS30 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4115.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS30 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4115.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS30 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 4115.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS30 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2271.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS30 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2271.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS30 C>T 1173.0 1098.0 1113.33 1157.18 0.07994714337580824 0.23608117776065035 100.0 2271.0 Lagging 1.068 0.962 1.11 1 1173.0 1113.33 1055.0 1186.0 [1080, 1124, 1118, 1143, 1167, 1127, 1151, 1121, 1106, 1162, 1106, 1162, 1149, 1099, 1099, 1104, 1099, 1066, 1104, 1128, 1097, 1144, 1111, 1100, 1124, 1089, 1111, 1125, 1092, 1131, 1078, 1143, 1109, 1157, 1055, 1093, 1125, 1080, 1121, 1131, 1118, 1129, 1130, 1164, 1137, 1089, 1095, 1115, 1123, 1100, 1093, 1127, 1107, 1122, 1116, 1122, 1057, 1186, 1115, 1107, 1080, 1129, 1115, 1118, 1131, 1115, 1078, 1077, 1099, 1055, 1133, 1136, 1100, 1118, 1095, 1106, 1101, 1117, 1098, 1094, 1111, 1103, 1131, 1140, 1145, 1093, 1132, 1108, 1117, 1076, 1105, 1091, 1087, 1098, 1140, 1131, 1107, 1143, 1096, 1101] 1098.0 1157.18 1089.0 1226.0 [1177, 1159, 1129, 1122, 1089, 1171, 1140, 1145, 1155, 1119, 1159, 1101, 1129, 1188, 1163, 1155, 1175, 1176, 1158, 1147, 1194, 1146, 1175, 1179, 1148, 1177, 1152, 1158, 1173, 1148, 1180, 1140, 1166, 1116, 1226, 1171, 1153, 1163, 1164, 1165, 1114, 1142, 1156, 1096, 1169, 1146, 1182, 1165, 1134, 1177, 1161, 1145, 1179, 1138, 1164, 1141, 1193, 1098, 1166, 1173, 1178, 1150, 1178, 1166, 1131, 1172, 1181, 1192, 1181, 1203, 1152, 1121, 1155, 1137, 1164, 1166, 1170, 1154, 1185, 1172, 1164, 1159, 1133, 1147, 1119, 1173, 1130, 1180, 1156, 1193, 1165, 1168, 1199, 1176, 1126, 1136, 1164, 1121, 1150, 1161] ESCC SBS30 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2271.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS30 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2271.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS30 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2271.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types