# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	82.858
E:A[C>A]A	85.465
A:A[C>G]A	57.217
E:A[C>G]A	62.041
A:A[C>T]A	116.099
E:A[C>T]A	129.862
A:A[T>A]A	157.924
E:A[T>A]A	173.71
A:A[T>C]A	133.992
E:A[T>C]A	149.714
A:A[T>G]A	38.123
E:A[T>G]A	40.016
A:A[C>A]C	47.087
E:A[C>A]C	51.927
A:A[C>G]C	16.028
E:A[C>G]C	17.159
A:A[C>T]C	72.149
E:A[C>T]C	71.599
A:A[T>A]C	75.897
E:A[T>A]C	82.48
A:A[T>C]C	60.325
E:A[T>C]C	62.883
A:A[T>G]C	0.0
E:A[T>G]C	0.0
A:A[C>A]G	11.61
E:A[C>A]G	12.214
A:A[C>G]G	0.0
E:A[C>G]G	0.0
A:A[C>T]G	146.151
E:A[C>T]G	152.004
A:A[T>A]G	80.694
E:A[T>A]G	84.286
A:A[T>C]G	131.173
E:A[T>C]G	115.964
A:A[T>G]G	31.431
E:A[T>G]G	30.218
A:A[C>A]T	51.411
E:A[C>A]T	55.755
A:A[C>G]T	29.811
E:A[C>G]T	30.002
A:A[C>T]T	39.698
E:A[C>T]T	43.463
A:A[T>A]T	159.105
E:A[T>A]T	189.341
A:A[T>C]T	84.514
E:A[T>C]T	80.734
A:A[T>G]T	0.0
E:A[T>G]T	0.0
A:C[C>A]A	119.375
E:C[C>A]A	123.891
A:C[C>G]A	45.976
E:C[C>G]A	48.048
A:C[C>T]A	110.501
E:C[C>T]A	117.317
A:C[T>A]A	236.746
E:C[T>A]A	260.253
A:C[T>C]A	84.434
E:C[T>C]A	86.215
A:C[T>G]A	0.0
E:C[T>G]A	0.0
A:C[C>A]C	70.071
E:C[C>A]C	64.77
A:C[C>G]C	25.475
E:C[C>G]C	20.961
A:C[C>T]C	51.395
E:C[C>T]C	41.714
A:C[T>A]C	131.545
E:C[T>A]C	140.968
A:C[T>C]C	77.984
E:C[T>C]C	81.996
A:C[T>G]C	28.468
E:C[T>G]C	28.135
A:C[C>A]G	13.53
E:C[C>A]G	13.279
A:C[C>G]G	8.308
E:C[C>G]G	6.03
A:C[C>T]G	85.905
E:C[C>T]G	85.768
A:C[T>A]G	437.01
E:C[T>A]G	440.255
A:C[T>C]G	113.329
E:C[T>C]G	107.503
A:C[T>G]G	77.674
E:C[T>G]G	71.762
A:C[C>A]T	124.002
E:C[C>A]T	112.733
A:C[C>G]T	1.966
E:C[C>G]T	1.767
A:C[C>T]T	83.903
E:C[C>T]T	80.229
A:C[T>A]T	272.043
E:C[T>A]T	259.967
A:C[T>C]T	89.034
E:C[T>C]T	78.128
A:C[T>G]T	96.817
E:C[T>G]T	91.116
A:G[C>A]A	125.622
E:G[C>A]A	137.964
A:G[C>G]A	27.806
E:G[C>G]A	21.93
A:G[C>T]A	78.554
E:G[C>T]A	76.965
A:G[T>A]A	163.61
E:G[T>A]A	190.363
A:G[T>C]A	202.406
E:G[T>C]A	187.703
A:G[T>G]A	23.122
E:G[T>G]A	22.237
A:G[C>A]C	51.523
E:G[C>A]C	54.497
A:G[C>G]C	16.889
E:G[C>G]C	18.139
A:G[C>T]C	56.457
E:G[C>T]C	56.834
A:G[T>A]C	57.256
E:G[T>A]C	55.249
A:G[T>C]C	47.756
E:G[T>C]C	46.361
A:G[T>G]C	0.0
E:G[T>G]C	0.0
A:G[C>A]G	3.838
E:G[C>A]G	5.576
A:G[C>G]G	2.323
E:G[C>G]G	2.976
A:G[C>T]G	87.972
E:G[C>T]G	91.023
A:G[T>A]G	160.577
E:G[T>A]G	166.233
A:G[T>C]G	132.535
E:G[T>C]G	131.69
A:G[T>G]G	36.021
E:G[T>G]G	35.284
A:G[C>A]T	116.129
E:G[C>A]T	107.043
A:G[C>G]T	13.87
E:G[C>G]T	12.253
A:G[C>T]T	67.288
E:G[C>T]T	71.584
A:G[T>A]T	107.435
E:G[T>A]T	104.854
A:G[T>C]T	163.88
E:G[T>C]T	150.031
A:G[T>G]T	48.604
E:G[T>G]T	35.815
A:T[C>A]A	39.966
E:T[C>A]A	42.168
A:T[C>G]A	94.885
E:T[C>G]A	84.185
A:T[C>T]A	92.355
E:T[C>T]A	86.59
A:T[T>A]A	269.569
E:T[T>A]A	253.874
A:T[T>C]A	146.459
E:T[T>C]A	133.233
A:T[T>G]A	19.591
E:T[T>G]A	19.679
A:T[C>A]C	66.898
E:T[C>A]C	68.001
A:T[C>G]C	28.357
E:T[C>G]C	25.418
A:T[C>T]C	51.063
E:T[C>T]C	50.17
A:T[T>A]C	49.569
E:T[T>A]C	55.037
A:T[T>C]C	87.471
E:T[T>C]C	80.427
A:T[T>G]C	3.953
E:T[T>G]C	3.632
A:T[C>A]G	0.0
E:T[C>A]G	0.0
A:T[C>G]G	21.385
E:T[C>G]G	21.132
A:T[C>T]G	111.918
E:T[C>T]G	108.052
A:T[T>A]G	131.895
E:T[T>A]G	129.146
A:T[T>C]G	76.513
E:T[T>C]G	68.148
A:T[T>G]G	55.993
E:T[T>G]G	54.305
A:T[C>A]T	204.865
E:T[C>A]T	200.977
A:T[C>G]T	157.12
E:T[C>G]T	137.835
A:T[C>T]T	102.301
E:T[C>T]T	93.512
A:T[T>A]T	141.582
E:T[T>A]T	137.802
A:T[T>C]T	134.266
E:T[T>C]T	124.791
A:T[T>G]T	74.276
E:T[T>G]T	64.244

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
ESCC	SBS25	C>A	262.0	226.0	242.02	244.03	0.2483978351828177	0.5798686088413598	8.895	5486.0	Lagging	1.159	0.992	1.169	1						262.0	242.02	210.0	280.0	[226, 253, 241, 252, 240, 240, 242, 251, 223, 226, 244, 236, 245, 254, 232, 239, 251, 258, 229, 248, 253, 238, 233, 241, 248, 231, 241, 248, 240, 253, 246, 227, 211, 271, 244, 247, 240, 280, 251, 264, 244, 275, 238, 237, 250, 251, 240, 236, 244, 242, 255, 250, 242, 229, 262, 233, 229, 233, 257, 217, 210, 233, 253, 237, 234, 241, 240, 246, 241, 249, 231, 233, 265, 237, 239, 231, 248, 257, 239, 245, 240, 242, 249, 223, 263, 240, 223, 226, 253, 231, 254, 221, 238, 235, 254, 236, 246, 261, 215, 242]	226.0	244.03	209.0	276.0	[272, 242, 250, 230, 239, 243, 236, 234, 259, 254, 251, 247, 243, 231, 249, 251, 243, 233, 257, 244, 232, 251, 250, 236, 240, 256, 239, 233, 250, 234, 232, 266, 264, 218, 236, 237, 249, 209, 240, 225, 240, 214, 249, 244, 233, 238, 247, 256, 248, 238, 221, 242, 249, 263, 232, 243, 246, 257, 237, 268, 255, 249, 237, 247, 248, 246, 242, 248, 252, 248, 251, 254, 237, 241, 258, 261, 238, 240, 248, 232, 249, 235, 234, 261, 217, 241, 263, 259, 229, 245, 225, 264, 239, 234, 239, 258, 248, 234, 276, 251]
ESCC	SBS25	C>G	0.0	0.0	0.0	0.0	1.0	1.0	0.0	5486.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
ESCC	SBS25	C>T	0.0	0.0	0.0	0.0	1.0	1.0	0.0	5486.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
ESCC	SBS25	T>A	2199.0	2280.0	2292.23	2239.88	0.1581035696878504	0.41283004645157056	81.644	5486.0	Leading	1.037	0.977	1.061							2199.0	2292.23	2202.0	2368.0	[2269, 2280, 2315, 2290, 2275, 2294, 2285, 2313, 2345, 2290, 2277, 2309, 2287, 2293, 2278, 2270, 2328, 2296, 2312, 2353, 2289, 2251, 2260, 2330, 2234, 2338, 2276, 2318, 2248, 2265, 2311, 2291, 2259, 2258, 2314, 2296, 2278, 2290, 2291, 2309, 2283, 2317, 2279, 2245, 2302, 2331, 2287, 2273, 2233, 2321, 2309, 2296, 2300, 2313, 2283, 2279, 2312, 2251, 2287, 2290, 2334, 2315, 2310, 2262, 2327, 2289, 2280, 2324, 2242, 2306, 2261, 2272, 2337, 2266, 2248, 2303, 2211, 2248, 2294, 2295, 2322, 2366, 2313, 2202, 2357, 2329, 2313, 2368, 2256, 2304, 2357, 2272, 2323, 2309, 2227, 2292, 2315, 2354, 2254, 2210]	2280.0	2239.88	2162.0	2335.0	[2240, 2243, 2222, 2257, 2284, 2256, 2240, 2228, 2219, 2262, 2269, 2220, 2209, 2234, 2261, 2248, 2223, 2264, 2224, 2162, 2251, 2294, 2268, 2206, 2264, 2201, 2247, 2224, 2258, 2286, 2235, 2253, 2284, 2265, 2190, 2235, 2246, 2222, 2267, 2232, 2251, 2213, 2257, 2277, 2220, 2210, 2240, 2261, 2271, 2190, 2267, 2214, 2211, 2238, 2283, 2230, 2226, 2273, 2251, 2204, 2199, 2234, 2214, 2246, 2199, 2252, 2250, 2214, 2262, 2224, 2282, 2276, 2228, 2224, 2262, 2218, 2297, 2282, 2227, 2203, 2205, 2173, 2205, 2335, 2193, 2174, 2231, 2176, 2282, 2202, 2189, 2310, 2218, 2226, 2300, 2235, 2252, 2196, 2284, 2329]
ESCC	SBS25	T>C	93.0	83.0	87.84	87.96	0.6688608329174367	1.0	3.208	5486.0	Lagging	1.12	0.999	1.122	1						93.0	87.84	71.0	105.0	[78, 83, 86, 86, 87, 77, 85, 78, 100, 78, 83, 83, 84, 90, 105, 95, 81, 93, 82, 100, 95, 82, 98, 81, 82, 98, 87, 94, 98, 82, 86, 104, 94, 90, 83, 94, 86, 77, 87, 85, 91, 91, 88, 83, 87, 87, 104, 88, 86, 81, 84, 92, 87, 88, 93, 86, 88, 89, 93, 88, 81, 79, 71, 76, 88, 88, 85, 91, 89, 97, 84, 87, 86, 93, 88, 89, 98, 80, 93, 89, 79, 86, 86, 89, 87, 96, 92, 73, 87, 91, 92, 87, 86, 85, 95, 97, 90, 79, 94, 90]	83.0	87.96	73.0	107.0	[98, 96, 87, 95, 88, 96, 93, 94, 73, 100, 88, 90, 90, 84, 73, 83, 94, 86, 91, 74, 80, 99, 83, 93, 90, 85, 94, 82, 82, 91, 91, 73, 85, 85, 89, 89, 92, 100, 85, 90, 84, 75, 87, 93, 92, 77, 73, 83, 90, 89, 89, 80, 84, 88, 87, 90, 84, 92, 87, 96, 95, 95, 107, 98, 85, 85, 82, 82, 89, 78, 91, 87, 86, 89, 91, 92, 80, 93, 87, 89, 89, 92, 86, 88, 88, 82, 85, 103, 88, 83, 87, 95, 85, 90, 88, 81, 84, 96, 81, 93]
ESCC	SBS25	T>G	183.0	160.0	171.94	167.66	0.4904771253940216	0.9179996677836765	6.252	5486.0	Lagging	1.144	1.026	1.115	1						183.0	171.94	147.0	195.0	[166, 169, 172, 175, 147, 170, 179, 160, 184, 169, 172, 183, 147, 177, 173, 174, 168, 169, 164, 169, 194, 177, 157, 181, 181, 161, 164, 195, 158, 184, 179, 170, 175, 176, 182, 190, 170, 174, 169, 166, 185, 183, 160, 173, 172, 159, 172, 180, 195, 164, 187, 160, 170, 185, 180, 174, 173, 159, 167, 171, 168, 186, 169, 174, 159, 170, 170, 165, 163, 174, 177, 173, 169, 161, 166, 167, 160, 175, 170, 186, 179, 166, 176, 160, 163, 170, 175, 176, 179, 179, 171, 177, 182, 166, 165, 169, 170, 175, 170, 165]	160.0	167.66	141.0	192.0	[172, 178, 167, 166, 192, 174, 151, 173, 158, 162, 168, 155, 176, 168, 167, 167, 173, 166, 169, 168, 151, 168, 174, 166, 154, 178, 168, 141, 188, 145, 166, 165, 162, 165, 154, 157, 169, 165, 173, 173, 159, 153, 177, 173, 172, 173, 157, 167, 158, 175, 152, 165, 170, 152, 158, 162, 167, 186, 167, 169, 164, 156, 175, 168, 174, 174, 174, 181, 177, 175, 172, 178, 168, 183, 179, 170, 188, 169, 167, 164, 158, 182, 156, 176, 160, 186, 160, 172, 158, 162, 170, 161, 164, 164, 177, 174, 167, 159, 166, 174]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change