# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on genic (transcribed:T, untranscribed:U and bitranscribed:B) and intergenic (nontranscribed:N) regions averaged across cancer types. MutationType Across_All_Cancer_Types T:A[C>A]A 33.0 U:A[C>A]A 25.0 B:A[C>A]A 0.0 N:A[C>A]A 121.0 T:A[C>A]C 19.0 U:A[C>A]C 13.0 B:A[C>A]C 0.0 N:A[C>A]C 70.0 T:A[C>A]G 5.0 U:A[C>A]G 1.0 B:A[C>A]G 0.0 N:A[C>A]G 14.0 T:A[C>A]T 19.0 U:A[C>A]T 16.0 B:A[C>A]T 0.0 N:A[C>A]T 77.0 T:A[C>G]A 18.0 U:A[C>G]A 16.0 B:A[C>G]A 0.0 N:A[C>G]A 79.0 T:A[C>G]C 4.0 U:A[C>G]C 5.0 B:A[C>G]C 0.0 N:A[C>G]C 18.0 T:A[C>G]G 0.0 U:A[C>G]G 0.0 B:A[C>G]G 0.0 N:A[C>G]G 0.0 T:A[C>G]T 11.0 U:A[C>G]T 6.0 B:A[C>G]T 0.0 N:A[C>G]T 38.0 T:A[C>T]A 56.0 U:A[C>T]A 41.0 B:A[C>T]A 0.0 N:A[C>T]A 163.0 T:A[C>T]C 29.0 U:A[C>T]C 25.0 B:A[C>T]C 0.0 N:A[C>T]C 96.0 T:A[C>T]G 63.0 U:A[C>T]G 60.0 B:A[C>T]G 0.0 N:A[C>T]G 191.0 T:A[C>T]T 15.0 U:A[C>T]T 12.0 B:A[C>T]T 0.0 N:A[C>T]T 53.0 T:A[T>A]A 76.0 U:A[T>A]A 42.0 B:A[T>A]A 0.0 N:A[T>A]A 256.0 T:A[T>A]C 38.0 U:A[T>A]C 27.0 B:A[T>A]C 0.0 N:A[T>A]C 116.0 T:A[T>A]G 35.0 U:A[T>A]G 19.0 B:A[T>A]G 0.0 N:A[T>A]G 122.0 T:A[T>A]T 71.0 U:A[T>A]T 61.0 B:A[T>A]T 1.0 N:A[T>A]T 262.0 T:A[T>C]A 60.0 U:A[T>C]A 44.0 B:A[T>C]A 0.0 N:A[T>C]A 191.0 T:A[T>C]C 24.0 U:A[T>C]C 20.0 B:A[T>C]C 0.0 N:A[T>C]C 86.0 T:A[T>C]G 54.0 U:A[T>C]G 43.0 B:A[T>C]G 0.0 N:A[T>C]G 165.0 T:A[T>C]T 33.0 U:A[T>C]T 26.0 B:A[T>C]T 0.0 N:A[T>C]T 113.0 T:A[T>G]A 16.0 U:A[T>G]A 7.0 B:A[T>G]A 0.0 N:A[T>G]A 57.0 T:A[T>G]C 0.0 U:A[T>G]C 0.0 B:A[T>G]C 0.0 N:A[T>G]C 0.0 T:A[T>G]G 10.0 U:A[T>G]G 4.0 B:A[T>G]G 0.0 N:A[T>G]G 44.0 T:A[T>G]T 0.0 U:A[T>G]T 0.0 B:A[T>G]T 0.0 N:A[T>G]T 0.0 T:C[C>A]A 38.0 U:C[C>A]A 44.0 B:C[C>A]A 0.0 N:C[C>A]A 171.0 T:C[C>A]C 26.0 U:C[C>A]C 22.0 B:C[C>A]C 0.0 N:C[C>A]C 88.0 T:C[C>A]G 2.0 U:C[C>A]G 3.0 B:C[C>A]G 0.0 N:C[C>A]G 17.0 T:C[C>A]T 46.0 U:C[C>A]T 40.0 B:C[C>A]T 0.0 N:C[C>A]T 164.0 T:C[C>G]A 21.0 U:C[C>G]A 18.0 B:C[C>G]A 0.0 N:C[C>G]A 56.0 T:C[C>G]C 9.0 U:C[C>G]C 5.0 B:C[C>G]C 0.0 N:C[C>G]C 28.0 T:C[C>G]G 1.0 U:C[C>G]G 1.0 B:C[C>G]G 0.0 N:C[C>G]G 7.0 T:C[C>G]T 0.0 U:C[C>G]T 0.0 B:C[C>G]T 0.0 N:C[C>G]T 0.0 T:C[C>T]A 43.0 U:C[C>T]A 46.0 B:C[C>T]A 0.0 N:C[C>T]A 149.0 T:C[C>T]C 19.0 U:C[C>T]C 20.0 B:C[C>T]C 0.0 N:C[C>T]C 55.0 T:C[C>T]G 38.0 U:C[C>T]G 43.0 B:C[C>T]G 0.0 N:C[C>T]G 98.0 T:C[C>T]T 34.0 U:C[C>T]T 32.0 B:C[C>T]T 0.0 N:C[C>T]T 110.0 T:C[T>A]A 123.0 U:C[T>A]A 53.0 B:C[T>A]A 0.0 N:C[T>A]A 357.0 T:C[T>A]C 72.0 U:C[T>A]C 44.0 B:C[T>A]C 0.0 N:C[T>A]C 193.0 T:C[T>A]G 214.0 U:C[T>A]G 134.0 B:C[T>A]G 2.0 N:C[T>A]G 588.0 T:C[T>A]T 99.0 U:C[T>A]T 76.0 B:C[T>A]T 1.0 N:C[T>A]T 391.0 T:C[T>C]A 34.0 U:C[T>C]A 23.0 B:C[T>C]A 0.0 N:C[T>C]A 122.0 T:C[T>C]C 31.0 U:C[T>C]C 28.0 B:C[T>C]C 0.0 N:C[T>C]C 112.0 T:C[T>C]G 40.0 U:C[T>C]G 45.0 B:C[T>C]G 0.0 N:C[T>C]G 137.0 T:C[T>C]T 28.0 U:C[T>C]T 29.0 B:C[T>C]T 0.0 N:C[T>C]T 123.0 T:C[T>G]A 0.0 U:C[T>G]A 0.0 B:C[T>G]A 0.0 N:C[T>G]A 0.0 T:C[T>G]C 12.0 U:C[T>G]C 10.0 B:C[T>G]C 0.0 N:C[T>G]C 34.0 T:C[T>G]G 26.0 U:C[T>G]G 28.0 B:C[T>G]G 0.0 N:C[T>G]G 95.0 T:C[T>G]T 25.0 U:C[T>G]T 32.0 B:C[T>G]T 0.0 N:C[T>G]T 140.0 T:G[C>A]A 43.0 U:G[C>A]A 31.0 B:G[C>A]A 0.0 N:G[C>A]A 179.0 T:G[C>A]C 25.0 U:G[C>A]C 14.0 B:G[C>A]C 0.0 N:G[C>A]C 71.0 T:G[C>A]G 1.0 U:G[C>A]G 0.0 B:G[C>A]G 0.0 N:G[C>A]G 4.0 T:G[C>A]T 35.0 U:G[C>A]T 44.0 B:G[C>A]T 0.0 N:G[C>A]T 147.0 T:G[C>G]A 10.0 U:G[C>G]A 6.0 B:G[C>G]A 0.0 N:G[C>G]A 30.0 T:G[C>G]C 7.0 U:G[C>G]C 3.0 B:G[C>G]C 0.0 N:G[C>G]C 22.0 T:G[C>G]G 0.0 U:G[C>G]G 0.0 B:G[C>G]G 0.0 N:G[C>G]G 0.0 T:G[C>G]T 2.0 U:G[C>G]T 4.0 B:G[C>G]T 0.0 N:G[C>G]T 15.0 T:G[C>T]A 27.0 U:G[C>T]A 32.0 B:G[C>T]A 0.0 N:G[C>T]A 99.0 T:G[C>T]C 23.0 U:G[C>T]C 23.0 B:G[C>T]C 0.0 N:G[C>T]C 69.0 T:G[C>T]G 44.0 U:G[C>T]G 39.0 B:G[C>T]G 0.0 N:G[C>T]G 104.0 T:G[C>T]T 28.0 U:G[C>T]T 28.0 B:G[C>T]T 0.0 N:G[C>T]T 97.0 T:G[T>A]A 69.0 U:G[T>A]A 50.0 B:G[T>A]A 0.0 N:G[T>A]A 252.0 T:G[T>A]C 18.0 U:G[T>A]C 20.0 B:G[T>A]C 0.0 N:G[T>A]C 83.0 T:G[T>A]G 65.0 U:G[T>A]G 49.0 B:G[T>A]G 0.0 N:G[T>A]G 227.0 T:G[T>A]T 31.0 U:G[T>A]T 44.0 B:G[T>A]T 0.0 N:G[T>A]T 171.0 T:G[T>C]A 76.0 U:G[T>C]A 69.0 B:G[T>C]A 2.0 N:G[T>C]A 245.0 T:G[T>C]C 16.0 U:G[T>C]C 17.0 B:G[T>C]C 0.0 N:G[T>C]C 63.0 T:G[T>C]G 50.0 U:G[T>C]G 54.0 B:G[T>C]G 1.0 N:G[T>C]G 174.0 T:G[T>C]T 44.0 U:G[T>C]T 66.0 B:G[T>C]T 0.0 N:G[T>C]T 199.0 T:G[T>G]A 7.0 U:G[T>G]A 1.0 B:G[T>G]A 0.0 N:G[T>G]A 33.0 T:G[T>G]C 0.0 U:G[T>G]C 0.0 B:G[T>G]C 0.0 N:G[T>G]C 0.0 T:G[T>G]G 7.0 U:G[T>G]G 9.0 B:G[T>G]G 0.0 N:G[T>G]G 44.0 T:G[T>G]T 11.0 U:G[T>G]T 14.0 B:G[T>G]T 0.0 N:G[T>G]T 58.0 T:T[C>A]A 11.0 U:T[C>A]A 13.0 B:T[C>A]A 0.0 N:T[C>A]A 53.0 T:T[C>A]C 25.0 U:T[C>A]C 20.0 B:T[C>A]C 0.0 N:T[C>A]C 92.0 T:T[C>A]G 0.0 U:T[C>A]G 0.0 B:T[C>A]G 0.0 N:T[C>A]G 0.0 T:T[C>A]T 58.0 U:T[C>A]T 80.0 B:T[C>A]T 0.0 N:T[C>A]T 297.0 T:T[C>G]A 34.0 U:T[C>G]A 30.0 B:T[C>G]A 0.0 N:T[C>G]A 115.0 T:T[C>G]C 10.0 U:T[C>G]C 9.0 B:T[C>G]C 0.0 N:T[C>G]C 31.0 T:T[C>G]G 5.0 U:T[C>G]G 5.0 B:T[C>G]G 0.0 N:T[C>G]G 22.0 T:T[C>G]T 53.0 U:T[C>G]T 54.0 B:T[C>G]T 0.0 N:T[C>G]T 185.0 T:T[C>T]A 34.0 U:T[C>T]A 35.0 B:T[C>T]A 0.0 N:T[C>T]A 114.0 T:T[C>T]C 19.0 U:T[C>T]C 18.0 B:T[C>T]C 0.0 N:T[C>T]C 60.0 T:T[C>T]G 45.0 U:T[C>T]G 53.0 B:T[C>T]G 1.0 N:T[C>T]G 120.0 T:T[C>T]T 36.0 U:T[C>T]T 38.0 B:T[C>T]T 0.0 N:T[C>T]T 123.0 T:T[T>A]A 120.0 U:T[T>A]A 93.0 B:T[T>A]A 0.0 N:T[T>A]A 364.0 T:T[T>A]C 16.0 U:T[T>A]C 15.0 B:T[T>A]C 0.0 N:T[T>A]C 71.0 T:T[T>A]G 59.0 U:T[T>A]G 34.0 B:T[T>A]G 1.0 N:T[T>A]G 183.0 T:T[T>A]T 48.0 U:T[T>A]T 57.0 B:T[T>A]T 0.0 N:T[T>A]T 210.0 T:T[T>C]A 45.0 U:T[T>C]A 51.0 B:T[T>C]A 0.0 N:T[T>C]A 195.0 T:T[T>C]C 31.0 U:T[T>C]C 30.0 B:T[T>C]C 0.0 N:T[T>C]C 104.0 T:T[T>C]G 24.0 U:T[T>C]G 28.0 B:T[T>C]G 0.0 N:T[T>C]G 90.0 T:T[T>C]T 43.0 U:T[T>C]T 62.0 B:T[T>C]T 1.0 N:T[T>C]T 174.0 T:T[T>G]A 7.0 U:T[T>G]A 6.0 B:T[T>G]A 0.0 N:T[T>G]A 29.0 T:T[T>G]C 0.0 U:T[T>G]C 0.0 B:T[T>G]C 0.0 N:T[T>G]C 2.0 T:T[T>G]G 19.0 U:T[T>G]G 24.0 B:T[T>G]G 0.0 N:T[T>G]G 78.0 T:T[T>G]T 18.0 U:T[T>G]T 23.0 B:T[T>G]T 0.0 N:T[T>G]T 93.0 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type genic_real_count intergenic_real_count genic_mean_sims_count intergenic_mean_sims_count genic_versus_intergenic_p_value genic_versus_intergenic_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Transcribed_real_count Transcribed_mean_sims_count Transcribed_min_sims_count Transcribed_max_sims_count Transcribed_sims_count_list UnTranscribed_real_count UnTranscribed_mean_sims_count UnTranscribed_min_sims_count UnTranscribed_max_sims_count UnTranscribed_sims_count_list NonTranscribed_real_count NonTranscribed_mean_sims_count NonTranscribed_min_sims_count NonTranscribed_max_sims_count NonTranscribed_sims_count_list ESCC SBS25 C>A 175.0 356.0 225.32 308.41 0.0019318347693876442 0.007714369162137726 8.746 6071.0 Intergenic 2.034 1.369 1.486 1 1 1 93.0 115.31 96.0 140.0 [98, 104, 114, 119, 107, 119, 122, 114, 101, 112, 115, 119, 114, 110, 133, 108, 97, 111, 121, 116, 119, 125, 117, 113, 113, 109, 113, 105, 114, 110, 121, 115, 134, 122, 101, 121, 124, 105, 115, 105, 117, 136, 109, 115, 124, 129, 96, 109, 107, 129, 97, 119, 97, 124, 140, 133, 110, 123, 127, 116, 115, 117, 110, 120, 101, 117, 123, 99, 123, 123, 124, 117, 118, 123, 129, 110, 140, 115, 107, 100, 111, 112, 111, 100, 113, 122, 108, 113, 125, 125, 129, 116, 113, 118, 136, 109, 104, 113, 106, 104] 82.0 110.01 89.0 129.0 [123, 128, 102, 101, 116, 108, 107, 103, 104, 93, 111, 110, 109, 96, 110, 118, 124, 115, 119, 129, 120, 125, 95, 106, 103, 107, 113, 97, 125, 106, 111, 115, 117, 89, 105, 104, 110, 114, 120, 114, 116, 96, 101, 108, 100, 111, 129, 104, 106, 95, 109, 113, 113, 105, 95, 101, 105, 110, 113, 110, 123, 98, 99, 114, 103, 108, 109, 121, 105, 99, 113, 112, 111, 110, 125, 124, 99, 129, 119, 116, 116, 124, 109, 123, 96, 114, 114, 106, 105, 110, 98, 116, 103, 110, 89, 121, 129, 116, 99, 104] 356.0 308.41 280.0 331.0 [310, 301, 319, 314, 310, 304, 308, 317, 327, 326, 306, 309, 309, 325, 291, 307, 313, 307, 294, 290, 297, 283, 322, 314, 317, 317, 309, 331, 294, 318, 301, 303, 284, 323, 326, 310, 303, 314, 301, 314, 302, 301, 322, 311, 310, 293, 309, 322, 320, 313, 325, 302, 325, 304, 298, 300, 318, 301, 298, 310, 294, 320, 325, 300, 329, 310, 301, 316, 306, 311, 297, 305, 306, 304, 280, 301, 294, 291, 307, 316, 307, 295, 312, 310, 323, 299, 312, 315, 302, 299, 308, 302, 316, 306, 307, 306, 302, 303, 326, 326] ESCC SBS25 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6071.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS25 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6071.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS25 T>A 1747.0 3225.0 2140.93 2839.08 1.0791746953944718e-15 8.152241465677089e-15 81.898 6071.0 Intergenic 1.846 1.326 1.392 1 1 1 1045.0 1034.75 979.0 1093.0 [1020, 1016, 988, 1022, 1031, 1038, 1041, 1042, 1049, 1036, 1024, 1059, 1008, 1036, 1084, 1079, 1052, 1042, 1004, 1051, 1066, 1085, 1026, 1025, 1026, 1035, 1018, 1037, 1050, 1091, 1038, 1040, 1016, 1014, 1076, 1058, 1007, 1013, 1020, 1065, 1015, 1055, 979, 1069, 1014, 1038, 1045, 1011, 1035, 1048, 1074, 1038, 1087, 986, 1024, 1021, 1080, 1046, 1036, 1031, 983, 1050, 1002, 1065, 1020, 999, 1055, 1069, 1053, 1065, 1048, 999, 1040, 1022, 1093, 1026, 1020, 1013, 1064, 990, 1006, 1005, 1024, 1047, 1027, 1033, 1019, 1043, 1017, 1041, 1014, 1036, 1022, 995, 1042, 1015, 1015, 1023, 1050, 1065] 702.0 1106.18 1032.0 1168.0 [1135, 1111, 1114, 1140, 1105, 1131, 1085, 1084, 1076, 1100, 1127, 1114, 1107, 1066, 1077, 1091, 1106, 1073, 1096, 1093, 1116, 1077, 1077, 1124, 1103, 1090, 1120, 1091, 1105, 1093, 1124, 1105, 1120, 1129, 1074, 1082, 1168, 1132, 1126, 1124, 1145, 1120, 1143, 1100, 1147, 1110, 1068, 1131, 1139, 1094, 1100, 1072, 1128, 1061, 1109, 1114, 1072, 1119, 1092, 1122, 1152, 1097, 1076, 1132, 1097, 1080, 1117, 1121, 1086, 1112, 1082, 1081, 1032, 1159, 1071, 1111, 1094, 1158, 1092, 1079, 1118, 1144, 1139, 1122, 1100, 1080, 1117, 1102, 1052, 1097, 1074, 1131, 1118, 1113, 1095, 1112, 1115, 1133, 1131, 1099] 3225.0 2839.08 2764.0 2926.0 [2833, 2848, 2872, 2824, 2843, 2814, 2852, 2863, 2857, 2836, 2839, 2807, 2868, 2874, 2826, 2814, 2820, 2861, 2875, 2831, 2801, 2821, 2878, 2834, 2849, 2851, 2841, 2853, 2824, 2796, 2812, 2832, 2840, 2839, 2827, 2841, 2803, 2835, 2828, 2793, 2826, 2813, 2863, 2813, 2823, 2834, 2871, 2838, 2813, 2836, 2805, 2867, 2764, 2926, 2851, 2842, 2838, 2815, 2853, 2828, 2845, 2836, 2906, 2780, 2859, 2901, 2807, 2789, 2838, 2796, 2846, 2900, 2905, 2791, 2819, 2849, 2866, 2813, 2827, 2906, 2850, 2831, 2817, 2807, 2859, 2867, 2842, 2831, 2912, 2843, 2884, 2823, 2840, 2881, 2836, 2841, 2848, 2825, 2811, 2807] ESCC SBS25 T>C 72.0 121.0 81.05 111.54 0.3495615257224908 0.7417188888828141 3.179 6071.0 Intergenic 1.681 1.376 1.221 1 1 37.0 38.37 26.0 55.0 [39, 44, 31, 41, 48, 34, 31, 46, 45, 36, 41, 42, 40, 40, 32, 47, 37, 38, 38, 27, 41, 46, 41, 43, 43, 37, 30, 42, 34, 41, 49, 36, 49, 40, 45, 37, 34, 33, 45, 33, 38, 38, 28, 41, 31, 39, 49, 37, 35, 35, 39, 36, 26, 37, 40, 43, 39, 40, 42, 32, 26, 41, 53, 45, 37, 40, 37, 41, 39, 44, 42, 44, 42, 33, 33, 32, 33, 41, 28, 39, 38, 41, 39, 31, 34, 30, 47, 48, 34, 35, 36, 55, 36, 31, 40, 36, 31, 38, 37, 29] 35.0 42.68 29.0 56.0 [56, 39, 52, 43, 41, 47, 38, 46, 37, 42, 32, 42, 43, 44, 42, 37, 47, 35, 45, 45, 45, 45, 47, 35, 40, 42, 39, 56, 46, 32, 35, 45, 42, 44, 45, 48, 38, 33, 56, 47, 37, 43, 49, 35, 42, 41, 40, 48, 46, 49, 34, 37, 52, 44, 36, 40, 38, 45, 48, 46, 46, 38, 33, 49, 36, 43, 43, 44, 47, 32, 39, 31, 40, 47, 46, 45, 47, 50, 46, 46, 41, 49, 44, 46, 29, 50, 41, 37, 33, 39, 42, 37, 42, 52, 48, 43, 56, 33, 54, 41] 121.0 111.54 92.0 129.0 [97, 109, 109, 109, 103, 111, 123, 102, 112, 116, 121, 109, 109, 108, 120, 108, 108, 120, 110, 120, 109, 102, 104, 114, 111, 113, 124, 95, 112, 119, 108, 111, 102, 108, 103, 107, 122, 126, 92, 113, 117, 111, 115, 116, 119, 114, 103, 108, 112, 108, 119, 122, 114, 112, 117, 111, 115, 107, 103, 114, 121, 114, 106, 99, 120, 111, 112, 107, 106, 116, 112, 117, 111, 113, 113, 116, 112, 102, 118, 108, 113, 103, 110, 115, 129, 113, 106, 107, 125, 118, 114, 101, 115, 109, 104, 113, 105, 121, 101, 122] ESCC SBS25 T>G 139.0 236.0 161.0 213.59 0.10116445850443126 0.28768483783557564 6.177 6071.0 Intergenic 1.698 1.327 1.28 1 1 74.0 76.07 52.0 95.0 [74, 84, 61, 62, 82, 85, 62, 84, 76, 75, 83, 73, 76, 75, 77, 83, 79, 68, 79, 64, 55, 80, 70, 74, 79, 68, 87, 79, 77, 75, 72, 75, 85, 73, 70, 80, 76, 95, 62, 85, 86, 75, 71, 72, 80, 74, 52, 71, 66, 76, 83, 70, 83, 95, 71, 72, 90, 64, 74, 95, 78, 79, 85, 82, 84, 92, 75, 77, 65, 75, 73, 72, 74, 82, 65, 74, 76, 64, 79, 94, 81, 74, 73, 77, 93, 80, 81, 70, 60, 84, 78, 86, 82, 79, 64, 79, 63, 77, 67, 75] 65.0 84.93 63.0 117.0 [94, 95, 93, 98, 80, 68, 88, 94, 75, 84, 84, 86, 84, 84, 79, 67, 86, 68, 73, 92, 79, 82, 86, 81, 75, 85, 97, 89, 84, 89, 93, 85, 93, 85, 91, 88, 80, 89, 77, 82, 77, 79, 94, 85, 63, 97, 93, 83, 85, 91, 75, 105, 98, 91, 78, 92, 84, 94, 77, 70, 117, 77, 88, 87, 76, 90, 78, 68, 64, 83, 82, 103, 99, 76, 84, 76, 86, 93, 80, 79, 82, 86, 67, 78, 84, 85, 83, 96, 104, 89, 88, 74, 93, 78, 96, 93, 90, 86, 69, 93] 236.0 213.59 181.0 245.0 [209, 196, 220, 214, 214, 220, 226, 195, 224, 214, 207, 216, 216, 217, 218, 225, 208, 237, 223, 217, 239, 213, 218, 219, 219, 222, 192, 207, 214, 210, 210, 215, 199, 216, 212, 208, 218, 191, 235, 208, 212, 219, 210, 217, 230, 202, 228, 221, 222, 208, 217, 200, 192, 188, 225, 211, 204, 218, 226, 209, 181, 218, 201, 205, 213, 194, 224, 228, 245, 216, 218, 198, 201, 215, 226, 225, 214, 217, 214, 202, 210, 216, 236, 220, 197, 211, 214, 207, 211, 202, 210, 215, 201, 217, 216, 203, 222, 211, 238, 207] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS25 T>A Intergenic ['ESCC'] 1 ['ESCC'] 1 ['ESCC'] 1 [] 0 [] 0 [] 0 ['ESCC'] 1 1.3