# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
# For real mutations on lagging:A and leading:E strands averaged across cancer types.
MutationType	Across_All_Cancer_Types
A:A[C>A]A	272.793
E:A[C>A]A	295.267
A:A[C>G]A	20.755
E:A[C>G]A	25.365
A:A[C>T]A	59.96
E:A[C>T]A	60.934
A:A[T>A]A	19.889
E:A[T>A]A	22.313
A:A[T>C]A	43.537
E:A[T>C]A	47.231
A:A[T>G]A	26.253
E:A[T>G]A	24.648
A:A[C>A]C	186.012
E:A[C>A]C	208.524
A:A[C>G]C	20.592
E:A[C>G]C	19.424
A:A[C>T]C	47.808
E:A[C>T]C	53.463
A:A[T>A]C	17.481
E:A[T>A]C	17.758
A:A[T>C]C	10.521
E:A[T>C]C	11.287
A:A[T>G]C	9.93
E:A[T>G]C	11.04
A:A[C>A]G	108.538
E:A[C>A]G	108.765
A:A[C>G]G	4.731
E:A[C>G]G	6.254
A:A[C>T]G	5.344
E:A[C>T]G	6.085
A:A[T>A]G	18.821
E:A[T>A]G	19.964
A:A[T>C]G	11.865
E:A[T>C]G	12.281
A:A[T>G]G	7.72
E:A[T>G]G	8.574
A:A[C>A]T	216.907
E:A[C>A]T	202.75
A:A[C>G]T	16.252
E:A[C>G]T	16.983
A:A[C>T]T	50.688
E:A[C>T]T	52.124
A:A[T>A]T	24.911
E:A[T>A]T	26.782
A:A[T>C]T	14.36
E:A[T>C]T	14.413
A:A[T>G]T	39.606
E:A[T>G]T	43.683
A:C[C>A]A	213.438
E:C[C>A]A	247.979
A:C[C>G]A	12.351
E:C[C>G]A	19.258
A:C[C>T]A	40.93
E:C[C>T]A	39.988
A:C[T>A]A	22.039
E:C[T>A]A	23.801
A:C[T>C]A	19.753
E:C[T>C]A	19.829
A:C[T>G]A	10.418
E:C[T>G]A	13.419
A:C[C>A]C	273.565
E:C[C>A]C	340.18
A:C[C>G]C	25.206
E:C[C>G]C	28.31
A:C[C>T]C	50.518
E:C[C>T]C	43.242
A:C[T>A]C	16.467
E:C[T>A]C	18.363
A:C[T>C]C	16.451
E:C[T>C]C	16.119
A:C[T>G]C	5.081
E:C[T>G]C	5.735
A:C[C>A]G	83.888
E:C[C>A]G	80.46
A:C[C>G]G	4.654
E:C[C>G]G	4.736
A:C[C>T]G	21.727
E:C[C>T]G	22.11
A:C[T>A]G	74.612
E:C[T>A]G	68.609
A:C[T>C]G	24.503
E:C[T>C]G	24.144
A:C[T>G]G	20.384
E:C[T>G]G	19.838
A:C[C>A]T	164.892
E:C[C>A]T	171.226
A:C[C>G]T	28.829
E:C[C>G]T	26.303
A:C[C>T]T	34.616
E:C[C>T]T	38.814
A:C[T>A]T	65.66
E:C[T>A]T	65.862
A:C[T>C]T	30.086
E:C[T>C]T	28.122
A:C[T>G]T	52.547
E:C[T>G]T	46.604
A:G[C>A]A	441.312
E:G[C>A]A	442.179
A:G[C>G]A	16.098
E:G[C>G]A	20.613
A:G[C>T]A	173.318
E:G[C>T]A	203.718
A:G[T>A]A	14.471
E:G[T>A]A	15.319
A:G[T>C]A	36.094
E:G[T>C]A	36.126
A:G[T>G]A	3.938
E:G[T>G]A	6.522
A:G[C>A]C	889.604
E:G[C>A]C	955.376
A:G[C>G]C	38.659
E:G[C>G]C	45.136
A:G[C>T]C	238.861
E:G[C>T]C	238.035
A:G[T>A]C	20.279
E:G[T>A]C	24.476
A:G[T>C]C	32.595
E:G[T>C]C	29.678
A:G[T>G]C	13.794
E:G[T>G]C	11.654
A:G[C>A]G	325.171
E:G[C>A]G	324.457
A:G[C>G]G	11.337
E:G[C>G]G	14.233
A:G[C>T]G	118.019
E:G[C>T]G	124.253
A:G[T>A]G	23.877
E:G[T>A]G	22.859
A:G[T>C]G	17.924
E:G[T>C]G	17.599
A:G[T>G]G	9.078
E:G[T>G]G	10.787
A:G[C>A]T	404.912
E:G[C>A]T	388.289
A:G[C>G]T	17.263
E:G[C>G]T	19.145
A:G[C>T]T	127.421
E:G[C>T]T	136.917
A:G[T>A]T	14.295
E:G[T>A]T	12.897
A:G[T>C]T	37.077
E:G[T>C]T	38.219
A:G[T>G]T	21.419
E:G[T>G]T	19.072
A:T[C>A]A	297.789
E:T[C>A]A	318.531
A:T[C>G]A	32.305
E:T[C>G]A	31.922
A:T[C>T]A	27.545
E:T[C>T]A	28.031
A:T[T>A]A	52.479
E:T[T>A]A	56.233
A:T[T>C]A	14.27
E:T[T>C]A	12.652
A:T[T>G]A	0.795
E:T[T>G]A	0.835
A:T[C>A]C	455.23
E:T[C>A]C	482.467
A:T[C>G]C	48.343
E:T[C>G]C	44.387
A:T[C>T]C	85.98
E:T[C>T]C	79.454
A:T[T>A]C	42.689
E:T[T>A]C	38.721
A:T[T>C]C	27.24
E:T[T>C]C	24.05
A:T[T>G]C	13.849
E:T[T>G]C	16.668
A:T[C>A]G	59.119
E:T[C>A]G	64.893
A:T[C>G]G	7.369
E:T[C>G]G	8.661
A:T[C>T]G	9.603
E:T[C>T]G	9.808
A:T[T>A]G	24.156
E:T[T>A]G	23.936
A:T[T>C]G	16.305
E:T[T>C]G	16.149
A:T[T>G]G	18.767
E:T[T>G]G	16.561
A:T[C>A]T	202.896
E:T[C>A]T	203.899
A:T[C>G]T	42.614
E:T[C>G]T	37.286
A:T[C>T]T	51.027
E:T[C>T]T	45.963
A:T[T>A]T	21.342
E:T[T>A]T	18.238
A:T[T>C]T	24.79
E:T[T>C]T	26.494
A:T[T>G]T	30.193
E:T[T>G]T	29.014

# There must be at least 1000 mutations on the strands.
# Signature and mutation type must have at least 5% of all signature mutations on the strands.
# Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1.
cancer_type	signature	mutation_type	Lagging_real_count	Leading_real_count	Lagging_mean_sims_count	Leading_mean_sims_count	lagging_versus_leading_p_value	lagging_versus_leading_q_value	percentage_of_mutations_on_strands	signature_number_of_mutations_on_strands	significant_strand	FC_REAL	FC_SIMS	FC	fold_change_1.1	fold_change_1.2	fold_change_1.3	fold_change_1.5	fold_change_1.75	fold_change_2+	Lagging_real_count.1	Lagging_mean_sims_count.1	Lagging_min_sims_count	Lagging_max_sims_count	Lagging_sims_count_list	Leading_real_count.1	Leading_mean_sims_count.1	Leading_min_sims_count	Leading_max_sims_count	Leading_sims_count_list
Liver-HCC	SBS24	C>A	2840.0	3001.0	2932.2	2951.17	0.18968448655815234	0.47551030556043244	92.479	6316.0	Leading	1.057	1.006	1.05							2840.0	2932.2	2836.0	3019.0	[2980, 2963, 2871, 2949, 2910, 2921, 2961, 2935, 2958, 2887, 2945, 2921, 2922, 2958, 2892, 3019, 2928, 2975, 2942, 2916, 2904, 3012, 2909, 2972, 2907, 2884, 2948, 2905, 2910, 2844, 3009, 2893, 2965, 2937, 2920, 2961, 2935, 2929, 2957, 2984, 2978, 2931, 2899, 2914, 2927, 2924, 2948, 2933, 2896, 2936, 2989, 2875, 2968, 2942, 2928, 2920, 2948, 2932, 2930, 2945, 2989, 2916, 2859, 2992, 2915, 3006, 2893, 2881, 2925, 2944, 2917, 2934, 2873, 2971, 2903, 2881, 2887, 2902, 2961, 2959, 2941, 2967, 2886, 2869, 2941, 2950, 2952, 2901, 2943, 2836, 2969, 2928, 2966, 2916, 2980, 2907, 2942, 2957, 2917, 2943]	3001.0	2951.17	2843.0	3015.0	[2905, 2918, 2988, 2945, 2947, 2948, 2947, 2958, 2929, 2962, 2898, 2959, 2943, 2913, 2974, 2884, 2949, 2901, 2916, 2974, 2975, 2843, 2975, 2871, 2992, 2995, 2929, 2905, 3001, 3015, 2888, 3005, 2901, 2969, 3003, 2901, 2961, 2964, 2917, 2907, 2903, 2945, 2987, 2995, 2982, 2951, 2933, 2910, 3013, 2934, 2900, 2992, 2925, 2956, 2963, 2967, 2990, 2950, 2954, 2920, 2878, 2990, 3012, 2923, 2993, 2930, 2956, 3013, 2966, 2952, 2972, 2953, 3005, 2893, 3012, 3003, 3005, 2966, 2966, 2929, 2949, 2897, 3002, 3009, 2962, 2944, 2973, 2981, 2952, 2997, 2887, 2958, 2930, 2980, 2922, 2947, 2919, 2930, 2969, 2947]
Liver-HCC	SBS24	C>G	6.0	9.0	8.37	8.49	0.7223934721942916	1.0	0.237	6316.0	Leading	1.5	1.014	1.479	1	1	1				6.0	8.37	3.0	15.0	[10, 8, 8, 8, 11, 9, 9, 7, 10, 6, 12, 10, 6, 8, 6, 4, 10, 10, 8, 7, 12, 8, 10, 13, 13, 7, 9, 8, 9, 5, 11, 5, 8, 10, 8, 12, 6, 6, 10, 11, 6, 9, 12, 11, 5, 10, 6, 14, 11, 10, 8, 10, 3, 8, 7, 10, 8, 6, 11, 11, 8, 10, 7, 8, 7, 6, 7, 7, 8, 7, 3, 5, 8, 15, 8, 11, 8, 7, 9, 9, 8, 5, 9, 9, 6, 14, 6, 7, 7, 7, 6, 8, 9, 9, 7, 10, 7, 8, 9, 4]	9.0	8.49	2.0	14.0	[6, 10, 9, 8, 7, 9, 9, 9, 5, 10, 6, 8, 12, 7, 11, 13, 7, 6, 10, 10, 4, 10, 7, 5, 2, 11, 9, 8, 9, 13, 6, 13, 9, 8, 8, 6, 11, 7, 6, 4, 11, 6, 5, 7, 12, 7, 12, 4, 6, 5, 9, 7, 14, 8, 10, 7, 9, 11, 6, 7, 8, 7, 11, 9, 11, 12, 11, 9, 9, 10, 14, 12, 8, 3, 10, 6, 9, 10, 7, 8, 9, 10, 9, 7, 8, 4, 12, 10, 10, 10, 9, 9, 9, 6, 11, 7, 9, 9, 6, 10]
Liver-HCC	SBS24	C>T	203.0	257.0	231.21	232.35	0.08646785460643874	0.25263009951069393	7.283	6316.0	Leading	1.266	1.005	1.26	1	1					203.0	231.21	192.0	256.0	[250, 239, 229, 224, 236, 247, 233, 233, 224, 241, 224, 224, 231, 230, 226, 227, 229, 234, 237, 241, 228, 225, 240, 246, 220, 192, 247, 225, 233, 256, 248, 235, 212, 216, 234, 238, 231, 239, 232, 221, 235, 216, 230, 232, 230, 224, 241, 226, 235, 230, 231, 227, 236, 195, 247, 252, 236, 246, 228, 234, 223, 239, 230, 233, 229, 251, 234, 234, 233, 225, 230, 218, 223, 226, 232, 229, 237, 226, 217, 234, 234, 225, 220, 222, 230, 232, 217, 214, 238, 236, 236, 247, 237, 233, 224, 224, 237, 242, 239, 223]	257.0	232.35	205.0	268.0	[213, 233, 237, 243, 228, 221, 231, 225, 233, 233, 232, 238, 237, 226, 236, 242, 235, 228, 228, 232, 228, 243, 225, 214, 240, 268, 226, 238, 229, 205, 210, 226, 241, 249, 223, 223, 232, 227, 227, 234, 233, 253, 236, 227, 240, 236, 224, 242, 231, 244, 237, 230, 224, 259, 218, 216, 224, 220, 242, 233, 241, 227, 232, 236, 234, 214, 238, 231, 233, 236, 237, 253, 240, 243, 228, 217, 225, 236, 242, 218, 225, 233, 250, 240, 226, 234, 244, 247, 224, 222, 230, 225, 222, 232, 239, 240, 234, 225, 231, 243]
Liver-HCC	SBS24	T>A	0.0	0.0	0.0	0.0	1.0	1.0	0.0	6316.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Liver-HCC	SBS24	T>C	0.0	0.0	0.0	0.0	1.0	1.0	0.0	6316.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]
Liver-HCC	SBS24	T>G	0.0	0.0	0.0	0.0	1.0	1.0	0.0	6316.0											0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]	0.0	0.0	0.0	0.0	[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]

Summary across all cancer types
signature	mutation_type	strand	fold_change_1.1	len(fold_change_1.1_cancer_types)	fold_change_1.2	len(fold_change_1.2_cancer_types)	fold_change_1.3	len(fold_change_1.3_cancer_types)	fold_change_1.5	len(fold_change_1.5_cancer_types)	fold_change_1.75	len(fold_change_1.75_cancer_types)	fold_change_2+	len(fold_change_2+_cancer_types)	all_cancer_types_list	len(all_cancer_types_list)	avg_fold_change