# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS22 Kidney-RCC [4151, 5687, 6612, 8406, 9842, 11730, 13297, 14492, 16221, 6989] [0.23, 0.315, 0.366, 0.466, 0.546, 0.652, 0.739, 0.808, 0.906, 1.0] [0.76, 0.852, 0.897, 0.93, 0.948, 0.963, 0.981, 0.992, 0.996, 0.972] 0.086 0.77 0.591 INC 0.5 97593 0.909 SBS22 Biliary-AdenoCA [335, 407, 511, 573, 689, 858, 920, 1032, 1044, 469] [0.277, 0.336, 0.422, 0.474, 0.569, 0.711, 0.762, 0.858, 0.869, 1.0] [0.738, 0.838, 0.877, 0.899, 0.918, 0.926, 0.939, 0.951, 0.964, 0.959] 0.081 0.723 0.533 INC 0.5 6842 0.885 SBS22 ESCC [100, 145, 169, 212, 229, 296, 332, 368, 389, 202] [0.192, 0.278, 0.324, 0.407, 0.439, 0.569, 0.639, 0.71, 0.752, 1.0] [0.726, 0.814, 0.845, 0.857, 0.897, 0.909, 0.926, 0.914, 0.921, 0.95] 0.081 0.808 0.474 INC 0.61 2442 0.752 SBS22 Liver-HCC [6261, 7859, 9152, 10645, 12247, 14020, 16084, 18410, 21523, 9152] [0.271, 0.34, 0.396, 0.461, 0.531, 0.609, 0.7, 0.804, 0.937, 1.0] [0.798, 0.846, 0.877, 0.896, 0.913, 0.919, 0.923, 0.95, 0.965, 1.0] 0.082 0.729 0.598 INC 0.5 125523 0.85 SBS22 ACROSS_ALL_CANCER_TYPES [0.242, 0.317, 0.377, 0.452, 0.521, 0.635, 0.71, 0.795, 0.866, 1.0] [0.756, 0.838, 0.874, 0.895, 0.919, 0.929, 0.942, 0.952, 0.961, 0.97] 4 0 0 4