# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 160.628 E:A[C>A]A 166.676 A:A[C>G]A 33.247 E:A[C>G]A 37.266 A:A[C>T]A 28.432 E:A[C>T]A 29.485 A:A[T>A]A 1813.481 E:A[T>A]A 1929.962 A:A[T>C]A 635.654 E:A[T>C]A 663.936 A:A[T>G]A 92.655 E:A[T>G]A 97.037 A:A[C>A]C 3.518 E:A[C>A]C 4.198 A:A[C>G]C 4.413 E:A[C>G]C 4.507 A:A[C>T]C 4.227 E:A[C>T]C 4.532 A:A[T>A]C 238.058 E:A[T>A]C 253.56 A:A[T>C]C 19.336 E:A[T>C]C 18.725 A:A[T>G]C 1.488 E:A[T>G]C 1.685 A:A[C>A]G 18.768 E:A[C>A]G 20.621 A:A[C>G]G 4.675 E:A[C>G]G 4.626 A:A[C>T]G 36.525 E:A[C>T]G 37.033 A:A[T>A]G 1627.812 E:A[T>A]G 1681.339 A:A[T>C]G 155.66 E:A[T>C]G 166.448 A:A[T>G]G 58.01 E:A[T>G]G 56.114 A:A[C>A]T 56.0 E:A[C>A]T 59.288 A:A[C>G]T 1.564 E:A[C>G]T 1.581 A:A[C>T]T 10.754 E:A[C>T]T 11.447 A:A[T>A]T 248.313 E:A[T>A]T 268.338 A:A[T>C]T 16.233 E:A[T>C]T 15.891 A:A[T>G]T 1.729 E:A[T>G]T 1.729 A:C[C>A]A 80.508 E:C[C>A]A 86.837 A:C[C>G]A 22.318 E:C[C>G]A 23.441 A:C[C>T]A 33.5 E:C[C>T]A 35.984 A:C[T>A]A 2965.606 E:C[T>A]A 3237.286 A:C[T>C]A 177.671 E:C[T>C]A 179.943 A:C[T>G]A 123.64 E:C[T>G]A 128.562 A:C[C>A]C 141.157 E:C[C>A]C 149.384 A:C[C>G]C 14.581 E:C[C>G]C 14.643 A:C[C>T]C 69.935 E:C[C>T]C 73.191 A:C[T>A]C 1364.838 E:C[T>A]C 1447.86 A:C[T>C]C 34.337 E:C[T>C]C 36.533 A:C[T>G]C 24.241 E:C[T>G]C 23.873 A:C[C>A]G 3.659 E:C[C>A]G 3.397 A:C[C>G]G 3.582 E:C[C>G]G 4.139 A:C[C>T]G 8.667 E:C[C>T]G 8.58 A:C[T>A]G 4114.594 E:C[T>A]G 4154.246 A:C[T>C]G 43.593 E:C[T>C]G 41.938 A:C[T>G]G 180.718 E:C[T>G]G 180.109 A:C[C>A]T 6.688 E:C[C>A]T 7.114 A:C[C>G]T 8.17 E:C[C>G]T 8.011 A:C[C>T]T 43.178 E:C[C>T]T 43.747 A:C[T>A]T 1572.055 E:C[T>A]T 1550.128 A:C[T>C]T 14.814 E:C[T>C]T 13.652 A:C[T>G]T 31.149 E:C[T>G]T 29.383 A:G[C>A]A 55.698 E:G[C>A]A 56.283 A:G[C>G]A 24.901 E:G[C>G]A 26.129 A:G[C>T]A 43.938 E:G[C>T]A 46.291 A:G[T>A]A 1312.622 E:G[T>A]A 1358.159 A:G[T>C]A 28.7 E:G[T>C]A 29.988 A:G[T>G]A 41.629 E:G[T>G]A 43.976 A:G[C>A]C 49.925 E:G[C>A]C 52.342 A:G[C>G]C 19.281 E:G[C>G]C 20.393 A:G[C>T]C 30.293 E:G[C>T]C 31.582 A:G[T>A]C 267.183 E:G[T>A]C 285.325 A:G[T>C]C 27.775 E:G[T>C]C 31.256 A:G[T>G]C 4.895 E:G[T>G]C 4.469 A:G[C>A]G 12.757 E:G[C>A]G 12.505 A:G[C>G]G 3.75 E:G[C>G]G 3.891 A:G[C>T]G 0.0 E:G[C>T]G 0.0 A:G[T>A]G 991.525 E:G[T>A]G 983.019 A:G[T>C]G 17.318 E:G[T>C]G 16.975 A:G[T>G]G 14.556 E:G[T>G]G 14.988 A:G[C>A]T 18.471 E:G[C>A]T 18.532 A:G[C>G]T 8.298 E:G[C>G]T 7.97 A:G[C>T]T 35.153 E:G[C>T]T 34.171 A:G[T>A]T 281.297 E:G[T>A]T 285.757 A:G[T>C]T 23.101 E:G[T>C]T 22.54 A:G[T>G]T 0.852 E:G[T>G]T 0.832 A:T[C>A]A 38.125 E:T[C>A]A 41.295 A:T[C>G]A 74.815 E:T[C>G]A 72.735 A:T[C>T]A 40.999 E:T[C>T]A 40.209 A:T[T>A]A 2196.599 E:T[T>A]A 2269.158 A:T[T>C]A 177.919 E:T[T>C]A 172.848 A:T[T>G]A 116.925 E:T[T>G]A 118.565 A:T[C>A]C 69.342 E:T[C>A]C 69.888 A:T[C>G]C 34.462 E:T[C>G]C 32.884 A:T[C>T]C 31.292 E:T[C>T]C 30.824 A:T[T>A]C 680.406 E:T[T>A]C 686.208 A:T[T>C]C 0.0 E:T[T>C]C 0.0 A:T[T>G]C 15.335 E:T[T>G]C 16.105 A:T[C>A]G 0.0 E:T[C>A]G 0.0 A:T[C>G]G 6.719 E:T[C>G]G 6.717 A:T[C>T]G 0.489 E:T[C>T]G 0.496 A:T[T>A]G 1796.144 E:T[T>A]G 1783.179 A:T[T>C]G 36.574 E:T[T>C]G 34.277 A:T[T>G]G 116.365 E:T[T>G]G 111.31 A:T[C>A]T 17.767 E:T[C>A]T 17.953 A:T[C>G]T 13.745 E:T[C>G]T 13.319 A:T[C>T]T 0.0 E:T[C>T]T 0.0 A:T[T>A]T 859.075 E:T[T>A]T 833.69 A:T[T>C]T 0.0 E:T[T>C]T 0.0 A:T[T>G]T 14.571 E:T[T>G]T 14.696 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Biliary-AdenoCA SBS22 C>A 33.0 32.0 31.85 32.98 1.0 1.0 1.044 6229.0 Lagging 1.031 0.966 1.068 33.0 31.85 19.0 41.0 [31.0, 36.0, 29.0, 28.0, 35.0, 25.0, 35.0, 34.0, 34.0, 34.0, 32.0, 31.0, 36.0, 23.0, 38.0, 19.0, 27.0, 26.0, 27.0, 27.0, 36.0, 33.0, 30.0, 33.0, 34.0, 36.0, 28.0, 31.0, 32.0, 33.0, 32.0, 33.0, 32.0, 34.0, 34.0, 28.0, 38.0, 36.0, 21.0, 33.0, 40.0, 36.0, 41.0, 34.0, 29.0, 32.0, 30.0, 35.0, 34.0, 32.0, 35.0, 27.0, 29.0, 32.0, 29.0, 35.0, 30.0, 35.0, 24.0, 34.0, 34.0, 33.0, 27.0, 27.0, 29.0, 27.0, 36.0, 32.0, 29.0, 36.0, 28.0, 29.0, 29.0, 36.0, 40.0, 34.0, 29.0, 24.0, 38.0, 25.0, 29.0, 34.0, 32.0, 34.0, 28.0, 25.0, 35.0, 30.0, 29.0, 37.0, 28.0, 34.0, 36.0, 31.0, 36.0, 35.0, 36.0, 35.0, 33.0, 39.0] 32.0 32.98 22.0 45.0 [34.0, 27.0, 37.0, 40.0, 29.0, 42.0, 34.0, 30.0, 31.0, 29.0, 35.0, 27.0, 26.0, 41.0, 23.0, 45.0, 38.0, 38.0, 41.0, 36.0, 31.0, 33.0, 32.0, 36.0, 34.0, 28.0, 37.0, 35.0, 35.0, 32.0, 36.0, 32.0, 36.0, 29.0, 29.0, 38.0, 31.0, 31.0, 38.0, 32.0, 26.0, 26.0, 22.0, 28.0, 40.0, 32.0, 33.0, 32.0, 30.0, 38.0, 30.0, 35.0, 37.0, 35.0, 32.0, 30.0, 35.0, 29.0, 38.0, 32.0, 31.0, 32.0, 37.0, 34.0, 38.0, 37.0, 32.0, 30.0, 37.0, 28.0, 33.0, 35.0, 35.0, 30.0, 26.0, 33.0, 37.0, 38.0, 29.0, 41.0, 38.0, 32.0, 33.0, 35.0, 35.0, 42.0, 30.0, 35.0, 28.0, 27.0, 37.0, 33.0, 28.0, 32.0, 24.0, 32.0, 27.0, 29.0, 31.0, 29.0] Biliary-AdenoCA SBS22 C>G 8.0 7.0 8.62 8.82 1.0 1.0 0.241 6229.0 Lagging 1.143 0.977 1.169 1 8.0 8.62 4.0 14.0 [5.0, 9.0, 7.0, 10.0, 10.0, 5.0, 9.0, 8.0, 10.0, 11.0, 6.0, 6.0, 7.0, 8.0, 11.0, 9.0, 11.0, 7.0, 7.0, 7.0, 10.0, 8.0, 9.0, 7.0, 6.0, 7.0, 9.0, 9.0, 8.0, 10.0, 11.0, 9.0, 7.0, 7.0, 11.0, 8.0, 10.0, 8.0, 7.0, 9.0, 7.0, 14.0, 4.0, 6.0, 10.0, 7.0, 10.0, 9.0, 5.0, 9.0, 9.0, 9.0, 9.0, 6.0, 12.0, 10.0, 6.0, 11.0, 8.0, 14.0, 7.0, 8.0, 9.0, 6.0, 10.0, 10.0, 9.0, 8.0, 6.0, 13.0, 7.0, 9.0, 7.0, 11.0, 11.0, 11.0, 8.0, 10.0, 9.0, 8.0, 6.0, 11.0, 9.0, 9.0, 10.0, 7.0, 10.0, 5.0, 5.0, 9.0, 12.0, 5.0, 12.0, 10.0, 12.0, 11.0, 6.0, 10.0, 8.0, 10.0] 7.0 8.82 3.0 14.0 [12.0, 8.0, 11.0, 6.0, 7.0, 11.0, 7.0, 11.0, 7.0, 7.0, 12.0, 8.0, 11.0, 10.0, 8.0, 9.0, 6.0, 11.0, 11.0, 11.0, 9.0, 9.0, 7.0, 8.0, 12.0, 11.0, 10.0, 7.0, 9.0, 7.0, 7.0, 10.0, 12.0, 11.0, 6.0, 8.0, 7.0, 8.0, 11.0, 8.0, 9.0, 3.0, 12.0, 11.0, 9.0, 11.0, 7.0, 10.0, 11.0, 7.0, 7.0, 9.0, 7.0, 12.0, 6.0, 8.0, 12.0, 8.0, 10.0, 5.0, 10.0, 9.0, 9.0, 12.0, 8.0, 8.0, 10.0, 11.0, 11.0, 4.0, 11.0, 10.0, 11.0, 8.0, 6.0, 6.0, 10.0, 7.0, 10.0, 9.0, 11.0, 3.0, 8.0, 8.0, 9.0, 9.0, 5.0, 12.0, 13.0, 9.0, 7.0, 14.0, 6.0, 9.0, 5.0, 7.0, 8.0, 7.0, 10.0, 7.0] Biliary-AdenoCA SBS22 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6229.0 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] 0.0 0.0 0.0 0.0 [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] Biliary-AdenoCA SBS22 T>A 2753.0 3040.0 2923.81 2889.8 0.0029652374008025863 0.01159119607971983 93.0 6229.0 Leading 1.104 0.988 1.117 1 2753.0 2923.81 2836.0 3046.0 [2921.0, 2871.0, 2970.0, 2916.0, 2952.0, 2890.0, 2897.0, 2918.0, 2914.0, 2860.0, 2984.0, 2921.0, 2953.0, 2906.0, 2924.0, 2925.0, 2866.0, 2958.0, 2909.0, 2925.0, 2948.0, 2925.0, 2918.0, 2859.0, 2954.0, 2944.0, 2970.0, 2974.0, 2974.0, 2896.0, 2971.0, 2919.0, 2944.0, 2843.0, 2866.0, 2894.0, 2982.0, 2897.0, 2920.0, 2970.0, 2880.0, 2962.0, 2873.0, 2956.0, 2915.0, 2868.0, 2914.0, 2968.0, 2838.0, 2964.0, 2860.0, 2931.0, 2935.0, 2957.0, 2912.0, 2948.0, 2836.0, 2852.0, 3006.0, 2957.0, 2891.0, 2876.0, 2906.0, 2944.0, 2837.0, 2850.0, 2946.0, 2951.0, 3013.0, 2876.0, 2992.0, 2922.0, 2917.0, 3016.0, 2895.0, 2907.0, 2906.0, 2917.0, 2935.0, 2924.0, 2964.0, 2914.0, 2947.0, 2879.0, 2860.0, 2953.0, 2995.0, 2991.0, 2951.0, 2880.0, 2941.0, 3046.0, 2922.0, 2958.0, 2905.0, 2927.0, 2848.0, 2954.0, 2912.0, 2933.0] 3040.0 2889.8 2776.0 3008.0 [2907.0, 2908.0, 2879.0, 2895.0, 2833.0, 2922.0, 2877.0, 2880.0, 2847.0, 2929.0, 2814.0, 2892.0, 2884.0, 2919.0, 2892.0, 2870.0, 2920.0, 2826.0, 2903.0, 2874.0, 2883.0, 2900.0, 2882.0, 2915.0, 2883.0, 2890.0, 2844.0, 2822.0, 2819.0, 2948.0, 2828.0, 2899.0, 2907.0, 2981.0, 2923.0, 2934.0, 2854.0, 2918.0, 2956.0, 2840.0, 2935.0, 2860.0, 2954.0, 2885.0, 2900.0, 2919.0, 2911.0, 2835.0, 3008.0, 2835.0, 2914.0, 2904.0, 2859.0, 2845.0, 2888.0, 2859.0, 2963.0, 2924.0, 2832.0, 2853.0, 2868.0, 2918.0, 2869.0, 2855.0, 2984.0, 3001.0, 2881.0, 2910.0, 2858.0, 2924.0, 2846.0, 2913.0, 2900.0, 2806.0, 2893.0, 2925.0, 2873.0, 2891.0, 2889.0, 2889.0, 2837.0, 2919.0, 2870.0, 2935.0, 2943.0, 2843.0, 2824.0, 2864.0, 2862.0, 2947.0, 2850.0, 2776.0, 2847.0, 2921.0, 2922.0, 2894.0, 2954.0, 2871.0, 2925.0, 2903.0] Biliary-AdenoCA SBS22 T>C 112.0 109.0 107.13 111.35 0.7748781810801579 1.0 3.548 6229.0 Lagging 1.028 0.962 1.068 112.0 107.13 86.0 127.0 [117.0, 116.0, 113.0, 116.0, 98.0, 115.0, 107.0, 96.0, 104.0, 108.0, 98.0, 109.0, 109.0, 94.0, 104.0, 110.0, 119.0, 92.0, 104.0, 113.0, 115.0, 111.0, 95.0, 117.0, 108.0, 101.0, 104.0, 93.0, 105.0, 106.0, 110.0, 116.0, 105.0, 107.0, 123.0, 102.0, 88.0, 125.0, 118.0, 107.0, 99.0, 116.0, 102.0, 113.0, 122.0, 105.0, 106.0, 86.0, 112.0, 95.0, 98.0, 103.0, 104.0, 103.0, 112.0, 106.0, 102.0, 106.0, 104.0, 107.0, 114.0, 105.0, 106.0, 111.0, 109.0, 96.0, 110.0, 103.0, 104.0, 104.0, 113.0, 113.0, 106.0, 102.0, 114.0, 111.0, 111.0, 127.0, 102.0, 103.0, 107.0, 110.0, 117.0, 101.0, 110.0, 96.0, 110.0, 113.0, 115.0, 108.0, 102.0, 115.0, 116.0, 112.0, 104.0, 107.0, 103.0, 92.0, 101.0, 111.0] 109.0 111.35 86.0 136.0 [108.0, 96.0, 104.0, 104.0, 120.0, 109.0, 103.0, 119.0, 117.0, 111.0, 123.0, 105.0, 105.0, 118.0, 120.0, 107.0, 98.0, 133.0, 121.0, 107.0, 105.0, 111.0, 119.0, 100.0, 107.0, 123.0, 114.0, 121.0, 104.0, 115.0, 110.0, 108.0, 119.0, 116.0, 99.0, 112.0, 122.0, 86.0, 102.0, 114.0, 106.0, 109.0, 115.0, 105.0, 93.0, 118.0, 103.0, 136.0, 108.0, 122.0, 113.0, 114.0, 115.0, 111.0, 100.0, 107.0, 111.0, 111.0, 114.0, 114.0, 104.0, 120.0, 109.0, 106.0, 101.0, 125.0, 113.0, 116.0, 120.0, 119.0, 108.0, 111.0, 111.0, 121.0, 112.0, 106.0, 109.0, 94.0, 116.0, 115.0, 109.0, 117.0, 103.0, 119.0, 111.0, 120.0, 112.0, 104.0, 108.0, 110.0, 113.0, 103.0, 100.0, 104.0, 118.0, 109.0, 119.0, 129.0, 120.0, 111.0] Biliary-AdenoCA SBS22 T>G 59.0 76.0 69.35 67.68 0.27423540987019035 0.6258348883164421 2.167 6229.0 Leading 1.288 0.976 1.32 1 1 1 59.0 69.35 57.0 82.0 [64.0, 81.0, 75.0, 65.0, 68.0, 80.0, 63.0, 77.0, 80.0, 68.0, 77.0, 72.0, 64.0, 66.0, 64.0, 73.0, 72.0, 72.0, 73.0, 62.0, 74.0, 63.0, 72.0, 67.0, 65.0, 74.0, 66.0, 67.0, 73.0, 61.0, 73.0, 82.0, 78.0, 66.0, 76.0, 65.0, 67.0, 66.0, 63.0, 73.0, 71.0, 76.0, 57.0, 59.0, 72.0, 61.0, 75.0, 74.0, 81.0, 64.0, 59.0, 74.0, 61.0, 68.0, 77.0, 58.0, 77.0, 58.0, 71.0, 69.0, 75.0, 69.0, 71.0, 63.0, 78.0, 66.0, 79.0, 75.0, 65.0, 66.0, 76.0, 61.0, 63.0, 80.0, 78.0, 58.0, 71.0, 74.0, 75.0, 69.0, 61.0, 65.0, 61.0, 69.0, 69.0, 77.0, 75.0, 73.0, 71.0, 67.0, 70.0, 63.0, 71.0, 70.0, 62.0, 70.0, 71.0, 58.0, 69.0, 62.0] 76.0 67.68 56.0 83.0 [74.0, 58.0, 59.0, 71.0, 69.0, 56.0, 70.0, 60.0, 62.0, 69.0, 61.0, 72.0, 73.0, 72.0, 72.0, 67.0, 67.0, 68.0, 64.0, 74.0, 65.0, 72.0, 62.0, 69.0, 73.0, 65.0, 65.0, 71.0, 66.0, 78.0, 61.0, 57.0, 62.0, 68.0, 69.0, 69.0, 68.0, 69.0, 75.0, 70.0, 69.0, 64.0, 81.0, 78.0, 58.0, 75.0, 57.0, 71.0, 57.0, 73.0, 70.0, 66.0, 74.0, 72.0, 57.0, 78.0, 60.0, 77.0, 59.0, 66.0, 62.0, 65.0, 63.0, 76.0, 59.0, 75.0, 60.0, 63.0, 70.0, 73.0, 67.0, 74.0, 71.0, 60.0, 57.0, 78.0, 68.0, 70.0, 63.0, 62.0, 76.0, 71.0, 75.0, 72.0, 66.0, 60.0, 60.0, 72.0, 67.0, 72.0, 62.0, 68.0, 67.0, 64.0, 74.0, 74.0, 66.0, 83.0, 57.0, 72.0] ESCC SBS22 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2183.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS22 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2183.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS22 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2183.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS22 T>A 1036.0 1147.0 1128.78 1107.85 0.04699133468265836 0.14838063310349844 100.0 2183.0 Leading 1.107 0.981 1.128 1 1036.0 1128.78 1060.0 1199.0 [1116, 1146, 1110, 1157, 1157, 1143, 1164, 1102, 1179, 1166, 1112, 1099, 1099, 1132, 1144, 1141, 1123, 1138, 1128, 1122, 1161, 1152, 1119, 1143, 1084, 1139, 1137, 1131, 1132, 1114, 1098, 1141, 1135, 1134, 1122, 1106, 1199, 1145, 1182, 1120, 1129, 1104, 1112, 1142, 1112, 1159, 1110, 1113, 1112, 1071, 1111, 1073, 1143, 1123, 1179, 1099, 1139, 1122, 1127, 1117, 1162, 1101, 1149, 1160, 1169, 1084, 1143, 1122, 1151, 1147, 1117, 1134, 1141, 1122, 1102, 1111, 1157, 1103, 1180, 1117, 1134, 1162, 1099, 1113, 1103, 1060, 1096, 1141, 1166, 1110, 1126, 1127, 1143, 1164, 1171, 1064, 1093, 1090, 1152, 1123] 1147.0 1107.85 1028.0 1171.0 [1110, 1107, 1117, 1096, 1093, 1108, 1110, 1143, 1071, 1073, 1139, 1137, 1137, 1110, 1096, 1119, 1112, 1084, 1099, 1116, 1075, 1085, 1120, 1082, 1135, 1082, 1096, 1097, 1098, 1139, 1130, 1088, 1126, 1101, 1109, 1129, 1028, 1093, 1055, 1094, 1106, 1125, 1148, 1094, 1122, 1086, 1108, 1130, 1131, 1155, 1121, 1147, 1110, 1120, 1070, 1142, 1091, 1119, 1100, 1115, 1091, 1134, 1090, 1082, 1069, 1171, 1075, 1122, 1069, 1091, 1121, 1115, 1074, 1129, 1131, 1129, 1088, 1102, 1064, 1126, 1121, 1086, 1128, 1141, 1113, 1171, 1121, 1104, 1086, 1097, 1104, 1091, 1102, 1059, 1079, 1146, 1138, 1141, 1101, 1104] ESCC SBS22 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2183.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS22 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2183.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS22 C>A 714.0 732.0 722.15 744.42 0.9704329440068776 1.0 1.638 88301.0 Leading 1.025 1.031 0.995 714.0 722.15 686.0 776.0 [691, 738, 730, 720, 751, 722, 755, 752, 719, 729, 717, 727, 732, 720, 712, 728, 710, 731, 705, 696, 718, 726, 701, 749, 715, 700, 743, 737, 703, 728, 724, 710, 721, 739, 752, 687, 712, 756, 708, 699, 746, 692, 741, 735, 702, 709, 692, 711, 700, 715, 721, 694, 732, 710, 737, 757, 693, 720, 715, 752, 749, 704, 710, 699, 746, 718, 698, 744, 709, 718, 735, 720, 712, 720, 713, 739, 725, 710, 697, 727, 755, 703, 726, 776, 760, 756, 730, 727, 746, 713, 698, 686, 722, 719, 715, 707, 735, 738, 710, 713] 732.0 744.42 707.0 783.0 [773, 738, 745, 751, 712, 725, 707, 740, 748, 731, 754, 751, 736, 738, 760, 747, 741, 731, 745, 769, 742, 742, 773, 739, 752, 762, 722, 729, 766, 748, 728, 756, 726, 716, 717, 783, 754, 718, 749, 777, 731, 767, 738, 742, 761, 752, 772, 754, 747, 733, 743, 762, 736, 738, 715, 732, 776, 729, 741, 715, 725, 755, 756, 758, 739, 750, 768, 738, 755, 730, 729, 750, 735, 747, 739, 709, 757, 760, 764, 732, 723, 772, 734, 721, 714, 717, 734, 728, 743, 765, 779, 777, 743, 756, 761, 754, 722, 735, 774, 769] Kidney-RCC SBS22 C>G 87.0 94.0 90.23 91.97 0.8334808794238169 1.0 0.205 88301.0 Leading 1.08 1.019 1.06 87.0 90.23 72.0 111.0 [93, 96, 87, 88, 94, 97, 91, 101, 85, 99, 95, 94, 91, 94, 87, 96, 99, 96, 96, 88, 90, 89, 98, 88, 79, 99, 79, 93, 83, 72, 99, 88, 86, 82, 89, 96, 80, 105, 86, 95, 91, 84, 94, 92, 102, 80, 85, 87, 90, 91, 80, 75, 79, 89, 87, 89, 77, 91, 100, 94, 81, 92, 95, 91, 92, 82, 90, 96, 94, 91, 88, 91, 91, 100, 76, 93, 90, 91, 89, 111, 81, 87, 86, 91, 88, 91, 96, 97, 92, 84, 96, 90, 94, 96, 89, 91, 97, 86, 79, 88] 94.0 91.97 78.0 106.0 [91, 89, 94, 88, 89, 86, 92, 85, 94, 87, 94, 97, 86, 97, 97, 89, 88, 87, 87, 92, 93, 95, 90, 90, 104, 83, 94, 88, 100, 97, 92, 91, 96, 96, 89, 93, 105, 80, 92, 90, 88, 100, 86, 82, 78, 100, 99, 96, 92, 88, 99, 106, 95, 91, 90, 94, 102, 86, 84, 94, 94, 91, 91, 96, 93, 97, 94, 82, 89, 95, 93, 95, 86, 84, 94, 88, 90, 91, 102, 78, 102, 95, 94, 91, 91, 96, 87, 92, 92, 96, 83, 91, 91, 86, 95, 88, 86, 99, 102, 100] Kidney-RCC SBS22 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 88301.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Kidney-RCC SBS22 T>A 38817.0 42381.0 41220.83 40648.65 9.198813514416345e-25 8.343161438717425e-24 91.956 88301.0 Leading 1.092 0.986 1.107 1 38817.0 41220.83 40741.0 41638.0 [41266, 41077, 41189, 41127, 41293, 41153, 41175, 41114, 41278, 41175, 41230, 41105, 41459, 40958, 41462, 40921, 41249, 41388, 41309, 41036, 41300, 41059, 41189, 41244, 41494, 41295, 41262, 41264, 41310, 41291, 41195, 41004, 41133, 41184, 41195, 41118, 41311, 41444, 41354, 41186, 41270, 41017, 41217, 41081, 41070, 41149, 41083, 41106, 41448, 41175, 40952, 41263, 41382, 41081, 41129, 41326, 41213, 41061, 41356, 41343, 41106, 41399, 41332, 41417, 41238, 41162, 41375, 41174, 40991, 41368, 40741, 41472, 41079, 41294, 41232, 41334, 41303, 41638, 41032, 41240, 40811, 41316, 41168, 41125, 41513, 41047, 41338, 41165, 41310, 41308, 41570, 41310, 41329, 41424, 41020, 41064, 41547, 41288, 41004, 40981] 42381.0 40648.65 40298.0 41125.0 [40644, 40859, 40641, 40642, 40612, 40812, 40645, 40690, 40466, 40744, 40741, 40721, 40326, 40885, 40298, 40860, 40584, 40494, 40678, 40669, 40579, 40693, 40737, 40744, 40337, 40480, 40683, 40775, 40409, 40725, 40831, 40809, 40760, 40623, 40647, 40733, 40574, 40542, 40441, 40647, 40655, 40791, 40734, 40807, 40750, 40728, 40804, 40803, 40508, 40537, 40818, 40641, 40510, 40619, 40760, 40530, 40743, 40818, 40446, 40539, 40638, 40528, 40459, 40555, 40713, 40721, 40591, 40669, 40985, 40565, 41125, 40406, 40804, 40547, 40764, 40613, 40808, 40348, 40806, 40584, 40913, 40446, 40702, 40728, 40382, 40752, 40571, 40794, 40574, 40565, 40426, 40654, 40527, 40305, 40721, 40693, 40330, 40631, 40833, 40768] Kidney-RCC SBS22 T>C 1517.0 1601.0 1564.75 1583.02 0.4187050371216921 0.8382259742271466 3.531 88301.0 Leading 1.055 1.012 1.043 1517.0 1564.75 1484.0 1642.0 [1618, 1617, 1517, 1588, 1589, 1499, 1617, 1571, 1543, 1581, 1568, 1599, 1540, 1556, 1600, 1502, 1543, 1587, 1576, 1565, 1571, 1579, 1553, 1521, 1615, 1574, 1534, 1609, 1563, 1610, 1547, 1613, 1593, 1611, 1604, 1600, 1501, 1612, 1539, 1606, 1571, 1591, 1556, 1563, 1532, 1535, 1563, 1584, 1583, 1550, 1585, 1623, 1484, 1529, 1552, 1513, 1553, 1568, 1642, 1512, 1600, 1581, 1566, 1545, 1568, 1519, 1556, 1572, 1561, 1573, 1535, 1538, 1559, 1581, 1560, 1548, 1561, 1524, 1543, 1589, 1570, 1517, 1539, 1574, 1604, 1571, 1561, 1579, 1586, 1575, 1531, 1557, 1549, 1505, 1523, 1557, 1529, 1535, 1617, 1597] 1601.0 1583.02 1519.0 1661.0 [1521, 1566, 1616, 1562, 1542, 1661, 1562, 1555, 1614, 1573, 1572, 1550, 1623, 1586, 1538, 1638, 1617, 1583, 1549, 1594, 1579, 1567, 1610, 1623, 1538, 1591, 1602, 1577, 1589, 1542, 1584, 1532, 1534, 1519, 1607, 1559, 1636, 1570, 1600, 1546, 1597, 1543, 1598, 1590, 1596, 1635, 1592, 1588, 1522, 1577, 1559, 1527, 1660, 1635, 1583, 1655, 1590, 1583, 1528, 1633, 1556, 1559, 1570, 1602, 1578, 1628, 1607, 1585, 1586, 1578, 1590, 1590, 1595, 1590, 1568, 1608, 1570, 1609, 1597, 1580, 1599, 1606, 1607, 1565, 1557, 1566, 1571, 1563, 1555, 1570, 1604, 1609, 1575, 1601, 1623, 1566, 1594, 1599, 1544, 1564] Kidney-RCC SBS22 T>G 1201.0 1157.0 1211.62 1186.48 0.7940455324180087 1.0 2.67 88301.0 Lagging 1.038 1.021 1.016 1201.0 1211.62 1146.0 1280.0 [1175, 1204, 1204, 1226, 1188, 1221, 1249, 1248, 1228, 1191, 1194, 1201, 1207, 1197, 1205, 1245, 1212, 1213, 1233, 1176, 1225, 1222, 1213, 1192, 1183, 1223, 1194, 1196, 1265, 1198, 1217, 1248, 1231, 1174, 1191, 1230, 1206, 1226, 1203, 1218, 1226, 1220, 1160, 1208, 1188, 1189, 1236, 1194, 1195, 1189, 1246, 1242, 1218, 1174, 1256, 1210, 1216, 1232, 1190, 1188, 1271, 1223, 1184, 1225, 1228, 1185, 1177, 1203, 1219, 1280, 1241, 1146, 1213, 1220, 1218, 1232, 1258, 1195, 1220, 1185, 1200, 1226, 1218, 1216, 1259, 1234, 1211, 1224, 1211, 1182, 1181, 1181, 1209, 1181, 1182, 1208, 1272, 1210, 1172, 1213] 1157.0 1186.48 1136.0 1256.0 [1229, 1201, 1207, 1177, 1203, 1157, 1162, 1171, 1161, 1209, 1189, 1174, 1182, 1180, 1200, 1169, 1194, 1205, 1160, 1221, 1194, 1188, 1208, 1210, 1215, 1155, 1202, 1209, 1172, 1178, 1210, 1166, 1164, 1222, 1200, 1177, 1198, 1177, 1190, 1174, 1168, 1184, 1224, 1200, 1202, 1213, 1159, 1199, 1204, 1189, 1145, 1162, 1189, 1223, 1147, 1201, 1167, 1175, 1170, 1205, 1155, 1185, 1229, 1153, 1148, 1189, 1210, 1165, 1188, 1139, 1164, 1227, 1189, 1180, 1185, 1166, 1155, 1200, 1160, 1228, 1188, 1172, 1188, 1179, 1157, 1160, 1175, 1157, 1177, 1205, 1256, 1206, 1203, 1221, 1211, 1169, 1136, 1160, 1226, 1201] Liver-HCC SBS22 C>A 402.0 398.0 396.31 406.14 0.7643291511922159 1.0 0.691 115697.0 Lagging 1.01 0.976 1.035 402.0 396.31 344.0 429.0 [404, 375, 392, 383, 396, 393, 418, 374, 406, 413, 404, 391, 371, 402, 398, 416, 384, 373, 392, 400, 386, 412, 393, 390, 400, 371, 396, 370, 401, 392, 398, 397, 390, 381, 387, 410, 392, 390, 404, 407, 412, 395, 412, 414, 401, 403, 394, 387, 370, 401, 402, 406, 392, 381, 385, 411, 403, 406, 399, 344, 418, 412, 405, 383, 401, 390, 390, 388, 395, 392, 406, 398, 367, 413, 396, 388, 387, 394, 416, 386, 402, 393, 386, 407, 418, 427, 419, 399, 390, 394, 396, 396, 412, 398, 410, 379, 393, 429, 419, 369] 398.0 406.14 375.0 462.0 [389, 430, 417, 431, 406, 416, 387, 434, 393, 389, 397, 417, 432, 401, 408, 391, 424, 445, 404, 394, 403, 389, 412, 407, 396, 421, 406, 423, 399, 416, 412, 404, 398, 424, 410, 405, 414, 411, 385, 397, 402, 410, 403, 401, 406, 400, 410, 414, 439, 397, 397, 390, 421, 423, 417, 401, 397, 394, 406, 462, 391, 390, 412, 420, 409, 402, 408, 408, 409, 401, 396, 404, 430, 387, 402, 416, 414, 400, 385, 421, 397, 403, 415, 397, 394, 381, 379, 406, 407, 403, 403, 399, 401, 402, 397, 407, 413, 379, 375, 424] Liver-HCC SBS22 C>G 120.0 97.0 102.57 109.18 0.17552947536802438 0.44777846526727844 0.188 115697.0 Lagging 1.237 0.939 1.317 1 1 1 120.0 102.57 87.0 123.0 [94, 102, 108, 108, 89, 91, 104, 97, 98, 91, 115, 101, 103, 95, 108, 104, 96, 107, 92, 96, 92, 102, 123, 110, 107, 113, 106, 109, 97, 102, 98, 111, 114, 99, 112, 109, 101, 100, 112, 100, 105, 107, 110, 109, 108, 101, 105, 105, 108, 96, 99, 109, 96, 93, 110, 92, 105, 114, 100, 97, 118, 108, 91, 93, 87, 103, 89, 97, 101, 106, 100, 101, 97, 101, 105, 105, 108, 102, 101, 110, 106, 97, 110, 98, 100, 109, 96, 98, 90, 103, 102, 93, 110, 106, 111, 96, 105, 120, 94, 105] 97.0 109.18 91.0 125.0 [112, 117, 100, 103, 122, 119, 106, 111, 108, 122, 96, 113, 109, 108, 104, 109, 112, 109, 116, 113, 118, 109, 95, 101, 108, 96, 99, 102, 119, 112, 113, 104, 97, 113, 103, 101, 108, 111, 96, 108, 102, 111, 98, 103, 104, 110, 111, 109, 107, 116, 113, 101, 109, 114, 104, 119, 106, 95, 116, 119, 98, 105, 121, 119, 124, 106, 124, 122, 113, 113, 116, 117, 113, 111, 108, 109, 104, 113, 113, 100, 107, 112, 106, 109, 106, 107, 118, 114, 125, 112, 107, 116, 97, 104, 103, 116, 109, 91, 113, 108] Liver-HCC SBS22 C>T 142.0 161.0 147.73 154.35 0.6838437932973298 1.0 0.262 115697.0 Leading 1.134 1.045 1.085 142.0 147.73 127.0 170.0 [154, 153, 153, 152, 153, 165, 149, 151, 147, 159, 152, 155, 143, 153, 143, 140, 146, 137, 142, 158, 141, 160, 138, 145, 146, 157, 141, 153, 164, 153, 156, 147, 147, 150, 142, 140, 141, 152, 162, 148, 143, 154, 152, 142, 153, 161, 147, 145, 145, 139, 138, 153, 141, 140, 136, 156, 170, 138, 142, 145, 156, 145, 159, 134, 154, 151, 156, 146, 141, 150, 150, 140, 140, 151, 146, 150, 135, 157, 157, 161, 137, 145, 127, 150, 144, 141, 141, 152, 138, 144, 154, 145, 153, 155, 136, 140, 145, 143, 135, 141] 161.0 154.35 131.0 179.0 [144, 146, 152, 144, 142, 135, 151, 156, 159, 144, 150, 146, 157, 154, 159, 159, 150, 161, 154, 143, 161, 136, 160, 153, 166, 148, 160, 152, 139, 147, 152, 157, 150, 146, 160, 163, 159, 155, 145, 157, 161, 151, 148, 161, 152, 145, 155, 164, 158, 161, 153, 149, 161, 164, 165, 144, 131, 171, 155, 161, 150, 158, 151, 166, 138, 151, 150, 161, 162, 144, 158, 166, 158, 156, 153, 150, 166, 144, 151, 147, 170, 158, 179, 151, 162, 161, 167, 156, 150, 156, 145, 151, 154, 147, 164, 161, 161, 156, 166, 158] Liver-HCC SBS22 T>A 53420.0 55760.0 55423.57 54331.53 2.1455642356983527e-13 1.5144922815507236e-12 94.367 115697.0 Leading 1.044 0.98 1.065 53420.0 55423.57 54962.0 55771.0 [55603, 55590, 55545, 55509, 55314, 55482, 55761, 55551, 55593, 55437, 55739, 55217, 55493, 55447, 55334, 55391, 55411, 55471, 55586, 55593, 55308, 55737, 55503, 55656, 55392, 55542, 55497, 55392, 55430, 55231, 55695, 55167, 55184, 55265, 55769, 55480, 55095, 55444, 55437, 55220, 55141, 55148, 55771, 55333, 55602, 55461, 55602, 55414, 55317, 55571, 55531, 55464, 55550, 55343, 55021, 55468, 54962, 55419, 55411, 55289, 55239, 55587, 55541, 55433, 55612, 55371, 55219, 55402, 55440, 55516, 55472, 55417, 55535, 55437, 55461, 55190, 55053, 54963, 55433, 55463, 55365, 55416, 55411, 55241, 55418, 55489, 55408, 55218, 55372, 55522, 55633, 55419, 55620, 55664, 55049, 55310, 55416, 55665, 55492, 55116] 55760.0 54331.53 53930.0 54764.0 [54196, 54070, 54135, 54218, 54484, 54236, 53930, 54338, 54359, 54211, 54146, 54383, 54454, 54450, 54507, 54286, 54423, 54305, 54219, 54091, 54400, 54104, 54257, 54106, 54365, 54124, 54246, 54191, 54416, 54388, 54120, 54524, 54764, 54432, 54086, 54275, 54611, 54251, 54191, 54524, 54403, 54553, 54033, 54362, 54215, 54199, 54061, 54298, 54391, 54186, 54315, 54154, 54210, 54286, 54736, 54221, 54572, 54394, 54333, 54478, 54598, 54139, 54286, 54433, 54308, 54269, 54514, 54435, 54365, 54228, 54343, 54310, 54181, 54344, 54336, 54484, 54596, 54668, 54297, 54291, 54403, 54378, 54422, 54534, 54231, 54520, 54383, 54594, 54402, 54300, 54229, 54425, 54117, 54077, 54598, 54374, 54457, 54277, 54193, 54598] Liver-HCC SBS22 T>C 1517.0 1666.0 1592.19 1598.16 0.07520079224884058 0.22429246587599558 2.751 115697.0 Leading 1.098 1.004 1.094 1517.0 1592.19 1531.0 1664.0 [1600, 1591, 1583, 1567, 1580, 1548, 1608, 1591, 1572, 1655, 1573, 1625, 1610, 1615, 1578, 1602, 1582, 1567, 1612, 1602, 1613, 1622, 1580, 1597, 1602, 1563, 1588, 1648, 1620, 1579, 1580, 1603, 1562, 1595, 1600, 1546, 1608, 1597, 1578, 1620, 1542, 1584, 1532, 1570, 1616, 1584, 1601, 1631, 1637, 1553, 1550, 1594, 1579, 1592, 1548, 1641, 1536, 1564, 1634, 1568, 1558, 1571, 1634, 1595, 1589, 1549, 1561, 1617, 1610, 1600, 1559, 1618, 1621, 1568, 1568, 1565, 1664, 1591, 1531, 1587, 1635, 1596, 1622, 1633, 1558, 1585, 1604, 1591, 1564, 1609, 1607, 1574, 1637, 1598, 1606, 1556, 1592, 1653, 1616, 1609] 1666.0 1598.16 1519.0 1684.0 [1597, 1613, 1626, 1623, 1590, 1654, 1581, 1604, 1622, 1556, 1627, 1562, 1590, 1553, 1592, 1614, 1621, 1617, 1589, 1577, 1604, 1590, 1603, 1599, 1590, 1610, 1624, 1555, 1569, 1632, 1623, 1583, 1616, 1613, 1579, 1638, 1561, 1583, 1584, 1554, 1633, 1606, 1646, 1621, 1554, 1613, 1596, 1592, 1558, 1627, 1643, 1604, 1620, 1609, 1634, 1571, 1684, 1633, 1549, 1603, 1626, 1636, 1555, 1567, 1585, 1645, 1619, 1553, 1586, 1595, 1643, 1573, 1576, 1622, 1598, 1621, 1519, 1614, 1660, 1580, 1545, 1608, 1563, 1551, 1620, 1605, 1598, 1605, 1617, 1563, 1597, 1588, 1565, 1613, 1587, 1638, 1576, 1520, 1580, 1590] Liver-HCC SBS22 T>G 971.0 1043.0 1016.73 998.6 0.16553059243698862 0.42816690893348786 1.741 115697.0 Leading 1.074 0.982 1.094 971.0 1016.73 954.0 1068.0 [1031, 1046, 996, 1052, 1005, 1032, 1005, 1007, 991, 1038, 1041, 1005, 1041, 1006, 1015, 1030, 1024, 1011, 987, 987, 1029, 1029, 1021, 1044, 1024, 1018, 1047, 1007, 1046, 1042, 986, 978, 1020, 1041, 963, 1005, 1007, 999, 1007, 997, 1048, 1030, 1001, 1043, 1005, 1032, 1010, 988, 1008, 980, 984, 987, 1027, 1017, 1006, 1007, 1044, 1037, 1018, 1006, 991, 1028, 1047, 1035, 1063, 978, 984, 1017, 1031, 1052, 1029, 987, 997, 1010, 1012, 1009, 1050, 1012, 1026, 1035, 1032, 990, 1031, 994, 1029, 985, 995, 1020, 1008, 1054, 1053, 1008, 1028, 1068, 1030, 991, 1060, 954, 1008, 1004] 1043.0 998.6 946.0 1053.0 [976, 988, 1034, 966, 1005, 989, 1033, 1000, 1013, 991, 969, 1012, 982, 1007, 980, 993, 996, 1004, 1023, 1033, 987, 983, 1002, 964, 993, 1009, 962, 1005, 965, 981, 1032, 1035, 995, 960, 1053, 995, 1016, 1005, 1003, 1021, 967, 975, 1018, 963, 1024, 984, 1000, 1012, 1012, 1031, 1034, 1029, 1002, 1005, 1037, 1018, 979, 971, 981, 1010, 1029, 977, 986, 976, 965, 1032, 1039, 1006, 981, 956, 984, 1029, 1016, 990, 1000, 1001, 946, 998, 1001, 981, 983, 1032, 1005, 1021, 992, 1036, 1010, 984, 1023, 979, 970, 996, 991, 947, 990, 995, 979, 1035, 984, 1003] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS22 T>A Leading ['Biliary-AdenoCA', 'Kidney-RCC'] 2 [] 0 [] 0 [] 0 [] 0 [] 0 ['Biliary-AdenoCA', 'ESCC', 'Kidney-RCC', 'Liver-HCC'] 4 1.1