# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered.
signature	cancer_type	dna_element	encode_element_list	fold_change_list	avg_fold_change	p_value_list	combined_p_value	q_value
SBS22	Biliary-AdenoCA	H3K27ac-human	['ENCFF752QSK_liver_Normal_H3K27ac-human', 'ENCFF285MWK_right-lobe-of-liver_Normal_H3K27ac-human']	[0.939, 0.873]	0.906	[0.407100154370301, 0.007015171021193863]	0.01958668034495505	0.03566876719676911
SBS22	Biliary-AdenoCA	H3K4me1-human	['ENCFF323TFF_liver_Normal_H3K4me1-human']	[0.996]	0.996	[0.8623018161331997]	0.8623018161331997	0.9042503603452001
SBS22	ESCC	H3K27ac-human	['ENCFF683MJC_esophagus-squamous-epithelium_Normal_H3K27ac-human']	[1.159]	1.159	[0.059178762410904154]	0.05917876241090417	0.09670737281543412
SBS22	ESCC	H3K36me3-human	['ENCFF848QKQ_esophagus-squamous-epithelium_Normal_H3K36me3-human']	[0.923]	0.923	[0.020206488825986062]	0.02020648882598606	0.03665829674955485
SBS22	ESCC	H3K4me1-human	['ENCFF353HXQ_esophagus-squamous-epithelium_Normal_H3K4me1-human']	[1.004]	1.004	[0.9069137133658552]	0.9069137133658552	0.9382118949001851
SBS22	Kidney-RCC	H3K27ac-human	['ENCFF953SWO_kidney_Normal_H3K27ac-human']	[0.876]	0.876	[4.2158459642385125e-12]	4.215845964238509e-12	1.4813370846871025e-11
SBS22	Kidney-RCC	H3K27me3-human	['ENCFF754PGB_kidney_Normal_H3K27me3-human', 'ENCFF532QZH_kidney-epithelial-cell_Normal_H3K27me3-human']	[0.982, 0.961]	0.971	[0.469529756133538, 0.05167076956900676]	0.11448473828094875	0.17172710742142314
SBS22	Kidney-RCC	H3K36me3-human	['ENCFF216OKG_kidney_Normal_H3K36me3-human']	[1.032]	1.032	[2.4908345863937858e-05]	2.490834586393786e-05	6.287718623679578e-05
SBS22	Kidney-RCC	H3K4me1-human	['ENCFF388YQF_kidney_Normal_H3K4me1-human']	[0.95]	0.95	[4.170769812423498e-08]	4.1707698124234966e-08	1.2502534195522623e-07
SBS22	Kidney-RCC	H3K4me3-human	['ENCFF913FVX_kidney_Normal_H3K4me3-human', 'ENCFF317HFX_kidney-epithelial-cell_Normal_H3K4me3-human']	[0.875, 0.893]	0.884	[3.296263880469717e-08, 5.3593684500934195e-08]	6.177714195985026e-14	2.274845428982202e-13
SBS22	Kidney-RCC	H3K9ac-human	['ENCFF314QTA_kidney_Normal_H3K9ac-human']	[0.959]	0.959	[0.00842811557373152]	0.008428115573731526	0.016307957365813346
SBS22	Kidney-RCC	H3K9me3-human	['ENCFF142DVG_kidney_Normal_H3K9me3-human']	[0.961]	0.961	[0.0015222749000671464]	0.0015222749000671477	0.0032467864322165904
SBS22	Liver-HCC	H3K27ac-human	['ENCFF752QSK_liver_Normal_H3K27ac-human', 'ENCFF285MWK_right-lobe-of-liver_Normal_H3K27ac-human']	[0.873, 0.849]	0.861	[3.8882509411964883e-16, 2.2250581414607012e-41]	1.1254812233403762e-54	7.656864280065645e-54
SBS22	Liver-HCC	H3K27me3-human	['ENCFF761EPK_liver_Normal_H3K27me3-human']	[0.996]	0.996	[0.6170437607890619]	0.617043760789062	0.7065344405095885
SBS22	Liver-HCC	H3K36me3-human	['ENCFF597ACD_liver_Normal_H3K36me3-human', 'ENCFF255EYP_right-lobe-of-liver_Normal_H3K36me3-human']	[1.024, 1.025]	1.024	[1.3398269365700067e-05, 0.009288847810819479]	2.1031968866339868e-06	5.772508193143496e-06
SBS22	Liver-HCC	H3K4me1-human	['ENCFF323TFF_liver_Normal_H3K4me1-human']	[0.976]	0.976	[7.985386159806368e-05]	7.985386159806374e-05	0.00019466281254877418
SBS22	Liver-HCC	H3K4me3-human	['ENCFF874ZJI_liver_Normal_H3K4me3-human', 'ENCFF250OOO_right-lobe-of-liver_Normal_H3K4me3-human']	[0.948, 0.919]	0.933	[0.000345737107265643, 5.31885871658658e-09]	5.153011139655576e-11	1.7451106569160146e-10
SBS22	Liver-HCC	H3K9ac-human	['ENCFF332PXX_liver_Normal_H3K9ac-human']	[0.953]	0.953	[0.0023258766826926313]	0.0023258766826926335	0.004858132189162567
SBS22	Liver-HCC	H3K9me3-human	['ENCFF323VPE_liver_Normal_H3K9me3-human']	[0.988]	0.988	[0.30762038294648175]	0.3076203829464818	0.4016125925027733