# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 21.834 E:A[C>A]A 22.278 A:A[C>G]A 23.897 E:A[C>G]A 23.38 A:A[C>T]A 213.064 E:A[C>T]A 225.719 A:A[T>A]A 18.478 E:A[T>A]A 18.936 A:A[T>C]A 32.647 E:A[T>C]A 36.757 A:A[T>G]A 35.079 E:A[T>G]A 34.515 A:A[C>A]C 9.063 E:A[C>A]C 11.034 A:A[C>G]C 13.51 E:A[C>G]C 16.361 A:A[C>T]C 107.305 E:A[C>T]C 111.186 A:A[T>A]C 4.15 E:A[T>A]C 4.07 A:A[T>C]C 7.012 E:A[T>C]C 7.27 A:A[T>G]C 15.705 E:A[T>G]C 17.163 A:A[C>A]G 3.17 E:A[C>A]G 3.815 A:A[C>G]G 3.593 E:A[C>G]G 3.162 A:A[C>T]G 25.607 E:A[C>T]G 28.93 A:A[T>A]G 13.995 E:A[T>A]G 15.119 A:A[T>C]G 21.541 E:A[T>C]G 23.541 A:A[T>G]G 12.459 E:A[T>G]G 11.099 A:A[C>A]T 11.424 E:A[C>A]T 11.982 A:A[C>G]T 18.012 E:A[C>G]T 21.203 A:A[C>T]T 331.07 E:A[C>T]T 329.192 A:A[T>A]T 17.967 E:A[T>A]T 17.821 A:A[T>C]T 17.67 E:A[T>C]T 19.172 A:A[T>G]T 18.162 E:A[T>G]T 19.433 A:C[C>A]A 31.478 E:C[C>A]A 34.152 A:C[C>G]A 12.055 E:C[C>G]A 12.593 A:C[C>T]A 1397.435 E:C[C>T]A 1452.214 A:C[T>A]A 2.504 E:C[T>A]A 2.508 A:C[T>C]A 5.544 E:C[T>C]A 6.167 A:C[T>G]A 10.378 E:C[T>G]A 9.862 A:C[C>A]C 18.669 E:C[C>A]C 20.672 A:C[C>G]C 9.844 E:C[C>G]C 9.995 A:C[C>T]C 810.184 E:C[C>T]C 871.369 A:C[T>A]C 9.056 E:C[T>A]C 9.586 A:C[T>C]C 1.138 E:C[T>C]C 1.239 A:C[T>G]C 19.521 E:C[T>G]C 21.521 A:C[C>A]G 2.23 E:C[C>A]G 2.695 A:C[C>G]G 0.215 E:C[C>G]G 0.162 A:C[C>T]G 115.981 E:C[C>T]G 120.114 A:C[T>A]G 6.963 E:C[T>A]G 6.642 A:C[T>C]G 4.266 E:C[T>C]G 4.6 A:C[T>G]G 11.938 E:C[T>G]G 9.641 A:C[C>A]T 0.831 E:C[C>A]T 0.898 A:C[C>G]T 27.281 E:C[C>G]T 22.649 A:C[C>T]T 3189.056 E:C[C>T]T 3243.651 A:C[T>A]T 6.937 E:C[T>A]T 7.186 A:C[T>C]T 5.232 E:C[T>C]T 5.265 A:C[T>G]T 28.679 E:C[T>G]T 28.547 A:G[C>A]A 10.583 E:G[C>A]A 12.249 A:G[C>G]A 8.04 E:G[C>G]A 8.427 A:G[C>T]A 680.593 E:G[C>T]A 722.111 A:G[T>A]A 2.735 E:G[T>A]A 3.056 A:G[T>C]A 19.577 E:G[T>C]A 19.105 A:G[T>G]A 4.476 E:G[T>G]A 4.699 A:G[C>A]C 4.145 E:G[C>A]C 4.2 A:G[C>G]C 11.2 E:G[C>G]C 10.896 A:G[C>T]C 391.471 E:G[C>T]C 407.626 A:G[T>A]C 1.403 E:G[T>A]C 1.379 A:G[T>C]C 5.807 E:G[T>C]C 5.707 A:G[T>G]C 8.212 E:G[T>G]C 6.883 A:G[C>A]G 2.735 E:G[C>A]G 2.944 A:G[C>G]G 2.788 E:G[C>G]G 4.668 A:G[C>T]G 34.468 E:G[C>T]G 37.776 A:G[T>A]G 8.149 E:G[T>A]G 8.434 A:G[T>C]G 11.895 E:G[T>C]G 11.565 A:G[T>G]G 3.535 E:G[T>G]G 3.828 A:G[C>A]T 4.819 E:G[C>A]T 4.401 A:G[C>G]T 2.547 E:G[C>G]T 2.418 A:G[C>T]T 1320.409 E:G[C>T]T 1349.136 A:G[T>A]T 6.068 E:G[T>A]T 5.511 A:G[T>C]T 53.848 E:G[T>C]T 51.168 A:G[T>G]T 6.743 E:G[T>G]T 6.176 A:T[C>A]A 32.803 E:T[C>A]A 30.06 A:T[C>G]A 15.176 E:T[C>G]A 14.643 A:T[C>T]A 446.691 E:T[C>T]A 450.701 A:T[T>A]A 10.405 E:T[T>A]A 11.385 A:T[T>C]A 20.291 E:T[T>C]A 19.076 A:T[T>G]A 17.459 E:T[T>G]A 19.151 A:T[C>A]C 22.446 E:T[C>A]C 22.717 A:T[C>G]C 25.413 E:T[C>G]C 24.669 A:T[C>T]C 196.11 E:T[C>T]C 201.006 A:T[T>A]C 12.933 E:T[T>A]C 13.256 A:T[T>C]C 8.937 E:T[T>C]C 10.472 A:T[T>G]C 14.704 E:T[T>G]C 14.621 A:T[C>A]G 3.996 E:T[C>A]G 3.899 A:T[C>G]G 2.216 E:T[C>G]G 2.223 A:T[C>T]G 26.042 E:T[C>T]G 24.974 A:T[T>A]G 6.006 E:T[T>A]G 6.064 A:T[T>C]G 15.44 E:T[T>C]G 14.528 A:T[T>G]G 15.224 E:T[T>G]G 13.365 A:T[C>A]T 25.358 E:T[C>A]T 23.034 A:T[C>G]T 19.945 E:T[C>G]T 18.053 A:T[C>T]T 743.353 E:T[C>T]T 744.245 A:T[T>A]T 12.907 E:T[T>A]T 13.59 A:T[T>C]T 24.313 E:T[T>C]T 24.769 A:T[T>G]T 42.544 E:T[T>G]T 35.085 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Liver-HCC SBS19 C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 17969.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS19 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 17969.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS19 C>T 8806.0 9163.0 8985.62 9029.94 0.0999951733341666 0.28478968090963125 100.0 17969.0 Leading 1.041 1.005 1.035 8806.0 8985.62 8834.0 9215.0 [8967, 8906, 8889, 9048, 8964, 8934, 8992, 8945, 9023, 9021, 8993, 9015, 8948, 8864, 8956, 8951, 9079, 8897, 9003, 8942, 8856, 9055, 9018, 9018, 8846, 9122, 9003, 9018, 9007, 9098, 9118, 9031, 8968, 8961, 8885, 9031, 8956, 8866, 8923, 8987, 8961, 9069, 8881, 9084, 8907, 9014, 8982, 9040, 8995, 8933, 8985, 8964, 9017, 8882, 9023, 8998, 8989, 8977, 8952, 8931, 8979, 8943, 8978, 8963, 9009, 8972, 8975, 8978, 8915, 8834, 9028, 8990, 9215, 9088, 9001, 8966, 9143, 8927, 9122, 8956, 8912, 9047, 8990, 9004, 9125, 8958, 8986, 9031, 9064, 8848, 9018, 9036, 8951, 8915, 9048, 8923, 8972, 9031, 9017, 9016] 9163.0 9029.94 8771.0 9204.0 [9070, 9117, 9122, 8961, 9064, 9087, 9041, 9006, 8997, 8968, 9025, 9024, 9071, 9117, 9086, 9044, 9014, 9120, 8974, 9088, 9136, 8967, 9039, 8998, 9085, 8962, 8951, 9023, 8972, 8888, 8928, 9021, 9059, 9051, 9159, 8952, 9086, 9077, 9126, 9083, 9085, 8902, 9095, 8927, 9139, 8983, 8990, 8997, 8981, 9057, 9032, 9123, 9056, 9104, 8978, 8968, 9039, 9026, 9091, 9090, 8976, 8990, 9062, 9035, 8999, 9011, 9034, 9021, 9108, 9168, 9003, 9035, 8771, 8896, 8995, 9025, 8954, 9113, 8936, 9104, 9103, 8990, 9003, 9066, 8909, 9045, 9037, 8928, 9001, 9183, 8938, 8992, 9063, 9101, 8962, 9204, 9026, 8992, 9002, 8991] Liver-HCC SBS19 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 17969.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS19 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 17969.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS19 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 17969.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change