# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS18 CNS-Medullo [500, 581, 605, 654, 702, 689, 808, 908, 1057, 435] [0.442, 0.513, 0.534, 0.577, 0.62, 0.61, 0.716, 0.807, 0.944, 1.0] [0.991, 0.929, 0.935, 0.937, 0.919, 0.92, 0.909, 0.904, 0.89, 0.896] 0.059 0.558 0.431 INC 0.6 6965 0.752 SBS18 ColoRect-AdenoCA [3261, 4167, 5471, 7051, 9674, 12916, 15278, 18231, 22133, 9940] [0.127, 0.162, 0.213, 0.275, 0.377, 0.505, 0.597, 0.715, 0.87, 1.0] [0.887, 0.946, 0.968, 0.985, 0.992, 0.983, 0.979, 0.992, 0.988, 0.96] 0.099 0.873 0.707 INC 0.51 108190 0.752 SBS18 Head-SCC [517, 624, 730, 861, 1156, 1419, 1564, 1862, 2144, 948] [0.211, 0.255, 0.298, 0.352, 0.472, 0.582, 0.641, 0.766, 0.883, 1.0] [0.947, 0.96, 0.973, 0.975, 0.963, 0.958, 0.948, 0.946, 0.936, 0.921] 0.09 0.789 0.628 INC 0.6 11853 0.752 SBS18 Lung-AdenoCA [87, 102, 159, 207, 214, 286, 333, 422, 540, 223] [0.154, 0.18, 0.281, 0.366, 0.38, 0.507, 0.59, 0.754, 0.965, 1.0] [0.883, 0.882, 0.896, 0.896, 0.921, 0.925, 0.936, 0.942, 0.909, 0.88] 0.099 0.846 0.785 INC 0.68 2573 0.755 SBS18 Panc-AdenoCA [1626, 1879, 2248, 2844, 3498, 4581, 5173, 6289, 7563, 3205] [0.196, 0.227, 0.272, 0.344, 0.423, 0.555, 0.627, 0.765, 0.922, 1.0] [0.927, 0.958, 0.972, 0.984, 0.977, 0.978, 0.975, 0.986, 0.98, 0.948] 0.094 0.804 0.695 INC 0.68 38978 0.753 SBS18 Prost-AdenoCA [230, 286, 303, 394, 475, 607, 749, 944, 1118, 481] [0.185, 0.23, 0.244, 0.318, 0.383, 0.49, 0.605, 0.765, 0.908, 1.0] [0.895, 0.937, 0.945, 0.944, 0.95, 0.95, 0.943, 0.939, 0.936, 0.906] 0.095 0.815 0.677 INC 0.7 5624 0.75 SBS18 Stomach-AdenoCA [6422, 8019, 10423, 12964, 17412, 22103, 25872, 29779, 36345, 16134] [0.154, 0.192, 0.25, 0.311, 0.418, 0.532, 0.623, 0.719, 0.88, 1.0] [0.941, 0.979, 0.99, 0.997, 0.993, 0.981, 0.974, 0.979, 0.974, 0.955] 0.096 0.846 0.687 INC 0.54 185665 0.751 SBS18 Breast-Cancer [2618, 3110, 3579, 4052, 4958, 5955, 7011, 8299, 10483, 4422] [0.229, 0.272, 0.313, 0.355, 0.434, 0.523, 0.616, 0.731, 0.926, 1.0] [0.962, 0.965, 0.961, 0.979, 0.973, 0.97, 0.963, 0.969, 0.995, 0.967] 0.088 0.771 0.653 INC 0.66 54492 0.753 SBS18 Eso-AdenoCA [3430, 4197, 5361, 7057, 9618, 12247, 14495, 17017, 21105, 9500] [0.14, 0.171, 0.218, 0.288, 0.392, 0.501, 0.593, 0.698, 0.868, 1.0] [0.94, 0.984, 0.994, 0.994, 0.985, 0.979, 0.973, 0.973, 0.956, 0.942] 0.097 0.86 0.697 INC 0.57 104110 0.751 SBS18 ESCC [13175, 15861, 19676, 24316, 31847, 40785, 47785, 55617, 67562, 30570] [0.167, 0.201, 0.249, 0.308, 0.404, 0.518, 0.608, 0.709, 0.863, 1.0] [0.947, 0.976, 0.993, 0.999, 0.991, 0.982, 0.975, 0.975, 0.966, 0.953] 0.094 0.833 0.662 INC 0.61 347707 0.751 SBS18 Liver-HCC [214, 232, 248, 295, 352, 475, 532, 622, 890, 338] [0.239, 0.259, 0.277, 0.329, 0.394, 0.532, 0.598, 0.701, 1.0, 0.953] [0.902, 0.912, 0.932, 0.936, 0.948, 0.932, 0.921, 0.919, 0.91, 0.939] 0.089 0.761 0.694 INC 0.69 4201 0.754 SBS18 Ovary-AdenoCA [299, 314, 316, 365, 377, 490, 489, 548, 603, 254] [0.461, 0.484, 0.487, 0.563, 0.583, 0.759, 0.758, 0.853, 0.941, 1.0] [0.959, 0.945, 0.943, 0.943, 0.937, 0.909, 0.912, 0.895, 0.878, 0.867] 0.065 0.539 0.457 INC 0.6 4055 0.765 SBS18 SoftTissue-Liposarc [214, 272, 343, 381, 514, 571, 655, 721, 832, 334] [0.248, 0.315, 0.398, 0.442, 0.596, 0.664, 0.762, 0.841, 0.973, 1.0] [0.927, 0.943, 0.936, 0.939, 0.935, 0.921, 0.906, 0.921, 0.931, 0.934] 0.089 0.752 0.657 INC 0.5 4837 0.836 SBS18 ACROSS_ALL_CANCER_TYPES [0.228, 0.267, 0.311, 0.373, 0.454, 0.562, 0.643, 0.758, 0.922, 1.0] [0.931, 0.947, 0.957, 0.962, 0.96, 0.953, 0.947, 0.949, 0.942, 0.928] 13 0 0 13