# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 2960.765 E:A[C>A]A 3141.658 A:A[C>G]A 103.087 E:A[C>G]A 104.135 A:A[C>T]A 439.251 E:A[C>T]A 451.697 A:A[T>A]A 211.542 E:A[T>A]A 221.193 A:A[T>C]A 90.167 E:A[T>C]A 92.67 A:A[T>G]A 60.21 E:A[T>G]A 62.96 A:A[C>A]C 994.511 E:A[C>A]C 1052.265 A:A[C>G]C 151.987 E:A[C>G]C 155.215 A:A[C>T]C 232.075 E:A[C>T]C 236.45 A:A[T>A]C 63.923 E:A[T>A]C 67.313 A:A[T>C]C 98.587 E:A[T>C]C 101.331 A:A[T>G]C 45.455 E:A[T>G]C 46.431 A:A[C>A]G 169.534 E:A[C>A]G 172.713 A:A[C>G]G 136.482 E:A[C>G]G 138.979 A:A[C>T]G 664.024 E:A[C>T]G 678.727 A:A[T>A]G 149.186 E:A[T>A]G 154.439 A:A[T>C]G 70.501 E:A[T>C]G 69.819 A:A[T>G]G 79.346 E:A[T>G]G 79.669 A:A[C>A]T 1530.689 E:A[C>A]T 1577.326 A:A[C>G]T 234.241 E:A[C>G]T 226.765 A:A[C>T]T 423.586 E:A[C>T]T 432.531 A:A[T>A]T 973.739 E:A[T>A]T 1019.095 A:A[T>C]T 183.073 E:A[T>C]T 183.648 A:A[T>G]T 149.95 E:A[T>G]T 144.047 A:C[C>A]A 3410.014 E:C[C>A]A 3535.92 A:C[C>G]A 31.819 E:C[C>G]A 32.341 A:C[C>T]A 755.384 E:C[C>T]A 754.386 A:C[T>A]A 61.635 E:C[T>A]A 64.729 A:C[T>C]A 22.817 E:C[T>C]A 22.98 A:C[T>G]A 9.587 E:C[T>G]A 9.595 A:C[C>A]C 1080.244 E:C[C>A]C 1128.709 A:C[C>G]C 79.071 E:C[C>G]C 81.468 A:C[C>T]C 394.484 E:C[C>T]C 397.253 A:C[T>A]C 194.471 E:C[T>A]C 203.071 A:C[T>C]C 127.695 E:C[T>C]C 126.718 A:C[T>G]C 86.633 E:C[T>G]C 85.86 A:C[C>A]G 421.924 E:C[C>A]G 427.046 A:C[C>G]G 151.895 E:C[C>G]G 149.728 A:C[C>T]G 844.73 E:C[C>T]G 834.499 A:C[T>A]G 244.24 E:C[T>A]G 244.206 A:C[T>C]G 65.439 E:C[T>C]G 62.67 A:C[T>G]G 151.703 E:C[T>G]G 146.449 A:C[C>A]T 2678.937 E:C[C>A]T 2609.146 A:C[C>G]T 181.975 E:C[C>G]T 173.981 A:C[C>T]T 422.847 E:C[C>T]T 406.631 A:C[T>A]T 259.583 E:C[T>A]T 258.587 A:C[T>C]T 155.798 E:C[T>C]T 149.357 A:C[T>G]T 341.734 E:C[T>G]T 323.414 A:G[C>A]A 5033.826 E:G[C>A]A 5219.174 A:G[C>G]A 35.177 E:G[C>G]A 35.816 A:G[C>T]A 575.046 E:G[C>T]A 575.203 A:G[T>A]A 103.133 E:G[T>A]A 105.522 A:G[T>C]A 51.929 E:G[T>C]A 50.425 A:G[T>G]A 44.95 E:G[T>G]A 45.416 A:G[C>A]C 980.769 E:G[C>A]C 1002.258 A:G[C>G]C 71.522 E:G[C>G]C 72.364 A:G[C>T]C 465.53 E:G[C>T]C 476.073 A:G[T>A]C 130.057 E:G[T>A]C 132.805 A:G[T>C]C 156.664 E:G[T>C]C 154.36 A:G[T>G]C 2.319 E:G[T>G]C 2.344 A:G[C>A]G 351.032 E:G[C>A]G 352.246 A:G[C>G]G 24.787 E:G[C>G]G 25.105 A:G[C>T]G 913.972 E:G[C>T]G 916.082 A:G[T>A]G 108.325 E:G[T>A]G 106.933 A:G[T>C]G 188.032 E:G[T>C]G 178.109 A:G[T>G]G 203.102 E:G[T>G]G 199.231 A:G[C>A]T 3162.029 E:G[C>A]T 3089.319 A:G[C>G]T 65.477 E:G[C>G]T 61.33 A:G[C>T]T 450.628 E:G[C>T]T 437.982 A:G[T>A]T 286.486 E:G[T>A]T 287.819 A:G[T>C]T 236.543 E:G[T>C]T 227.612 A:G[T>G]T 198.947 E:G[T>G]T 188.396 A:T[C>A]A 4111.339 E:T[C>A]A 4097.697 A:T[C>G]A 141.17 E:T[C>G]A 133.634 A:T[C>T]A 760.775 E:T[C>T]A 716.853 A:T[T>A]A 1022.39 E:T[T>A]A 1026.792 A:T[T>C]A 115.612 E:T[T>C]A 112.941 A:T[T>G]A 58.485 E:T[T>G]A 57.357 A:T[C>A]C 2354.164 E:T[C>A]C 2324.639 A:T[C>G]C 234.998 E:T[C>G]C 225.415 A:T[C>T]C 721.21 E:T[C>T]C 679.423 A:T[T>A]C 192.775 E:T[T>A]C 195.875 A:T[T>C]C 417.013 E:T[T>C]C 405.455 A:T[T>G]C 78.767 E:T[T>G]C 78.403 A:T[C>A]G 513.46 E:T[C>A]G 500.802 A:T[C>G]G 50.643 E:T[C>G]G 47.869 A:T[C>T]G 670.066 E:T[C>T]G 647.432 A:T[T>A]G 113.385 E:T[T>A]G 110.204 A:T[T>C]G 181.459 E:T[T>C]G 172.571 A:T[T>G]G 86.422 E:T[T>G]G 83.284 A:T[C>A]T 7521.814 E:T[C>A]T 7178.576 A:T[C>G]T 232.463 E:T[C>G]T 209.275 A:T[C>T]T 295.793 E:T[C>T]T 269.668 A:T[T>A]T 587.054 E:T[T>A]T 569.559 A:T[T>C]T 224.284 E:T[T>C]T 211.932 A:T[T>G]T 363.903 E:T[T>G]T 345.093 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list Breast-Cancer SBS18 C>A 25208.0 24110.0 24907.71 24948.81 0.00028018296239769086 0.0012246776992726064 99.982 49327.0 Lagging 1.046 0.998 1.047 25208.0 24907.71 24663.0 25266.0 [24837, 24906, 24934, 25033, 24890, 25153, 24834, 24701, 24944, 24702, 24887, 25107, 25010, 24925, 24924, 24882, 24950, 25266, 25103, 24959, 24876, 24942, 24929, 24923, 24925, 25025, 25031, 24960, 24878, 25021, 24966, 24851, 24920, 24885, 24866, 24840, 24703, 24782, 24705, 25009, 24848, 24876, 24944, 24687, 24851, 25031, 24897, 24863, 24927, 24901, 24819, 25104, 24807, 24857, 24965, 24787, 24970, 24764, 24927, 24970, 25037, 24917, 24685, 24663, 24927, 25039, 24853, 25038, 24915, 25070, 24821, 24844, 25080, 25006, 25073, 24792, 25011, 24970, 24891, 24752, 24926, 24886, 25013, 25043, 24755, 24822, 24899, 24791, 25012, 24900, 24935, 25001, 24991, 24806, 24755, 24748, 24807, 24713, 24897, 24908] 24110.0 24948.81 24623.0 25169.0 [25146, 24962, 25013, 24812, 24982, 24652, 24964, 25106, 24912, 25153, 25069, 24783, 24860, 25009, 24905, 24970, 24860, 24623, 24802, 24790, 24927, 24979, 24928, 24869, 25020, 24920, 24719, 24868, 24980, 24858, 24954, 24967, 24933, 24920, 25088, 25051, 25126, 24988, 25074, 24937, 25066, 24912, 24856, 25087, 25026, 24910, 24918, 25013, 24940, 24824, 25049, 24696, 24997, 24953, 24862, 25002, 24887, 25032, 24921, 25048, 24845, 25032, 25169, 25114, 24856, 24896, 24939, 24870, 24998, 24798, 25043, 24930, 24825, 24766, 24857, 24880, 24931, 24852, 24999, 25069, 25092, 25085, 24838, 24798, 25167, 25043, 24920, 25154, 24825, 24877, 24911, 24923, 24866, 24937, 25105, 25052, 25048, 25094, 24938, 25061] Breast-Cancer SBS18 C>G 4.0 5.0 4.99 5.12 1.0 1.0 0.018 49327.0 Leading 1.25 1.026 1.218 1 1 4.0 4.99 0.0 8.0 [3, 4, 6, 8, 4, 5, 7, 6, 5, 4, 4, 5, 4, 6, 6, 7, 4, 1, 4, 5, 8, 5, 5, 5, 5, 3, 4, 5, 7, 6, 2, 6, 5, 7, 1, 3, 3, 7, 5, 3, 7, 3, 6, 5, 5, 6, 6, 7, 7, 4, 4, 5, 4, 7, 7, 4, 6, 4, 8, 4, 6, 4, 5, 5, 0, 5, 5, 6, 5, 5, 4, 6, 6, 4, 6, 4, 6, 7, 5, 6, 5, 7, 6, 7, 5, 6, 5, 2, 5, 3, 4, 4, 2, 4, 6, 6, 5, 4, 5, 6] 5.0 5.12 3.0 10.0 [7, 7, 4, 3, 6, 4, 4, 4, 4, 5, 7, 6, 4, 4, 4, 4, 4, 10, 4, 6, 3, 5, 5, 6, 5, 7, 6, 5, 4, 5, 8, 5, 6, 4, 8, 7, 6, 4, 6, 7, 3, 8, 5, 6, 4, 4, 5, 4, 4, 6, 6, 5, 5, 3, 3, 6, 5, 7, 3, 5, 4, 7, 5, 3, 9, 3, 5, 5, 5, 5, 6, 4, 3, 6, 3, 4, 4, 4, 5, 4, 6, 3, 5, 4, 6, 5, 4, 7, 6, 8, 6, 6, 9, 7, 5, 4, 4, 4, 6, 3] Breast-Cancer SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 49327.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 49327.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 49327.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Breast-Cancer SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 49327.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] CNS-Medullo SBS18 C>A 3237.0 3075.0 3171.59 3177.75 0.13541081087088538 0.36569275325454464 99.984 6313.0 Lagging 1.053 0.998 1.055 3237.0 3171.59 3016.0 3323.0 [3100, 3178, 3308, 3208, 3126, 3133, 3194, 3219, 3134, 3226, 3158, 3113, 3167, 3141, 3139, 3201, 3092, 3176, 3235, 3165, 3160, 3140, 3154, 3158, 3222, 3128, 3157, 3133, 3178, 3203, 3083, 3163, 3194, 3093, 3159, 3180, 3125, 3204, 3121, 3237, 3186, 3169, 3149, 3172, 3141, 3203, 3180, 3173, 3178, 3173, 3158, 3212, 3171, 3146, 3166, 3167, 3146, 3268, 3201, 3141, 3153, 3180, 3162, 3223, 3141, 3161, 3225, 3266, 3125, 3160, 3181, 3154, 3206, 3161, 3323, 3179, 3182, 3183, 3198, 3237, 3203, 3129, 3016, 3173, 3241, 3107, 3100, 3109, 3247, 3181, 3138, 3184, 3147, 3173, 3128, 3181, 3233, 3179, 3150, 3235] 3075.0 3177.75 3074.0 3291.0 [3232, 3153, 3074, 3121, 3239, 3207, 3130, 3086, 3210, 3101, 3198, 3274, 3197, 3195, 3217, 3144, 3291, 3144, 3122, 3145, 3174, 3203, 3183, 3182, 3114, 3203, 3160, 3222, 3165, 3139, 3271, 3201, 3131, 3229, 3145, 3160, 3230, 3174, 3224, 3142, 3201, 3218, 3213, 3168, 3191, 3186, 3131, 3207, 3167, 3202, 3179, 3162, 3186, 3211, 3182, 3138, 3178, 3139, 3135, 3183, 3179, 3164, 3213, 3160, 3211, 3188, 3135, 3084, 3215, 3162, 3160, 3166, 3167, 3176, 3075, 3170, 3193, 3191, 3186, 3127, 3121, 3175, 3287, 3211, 3133, 3245, 3216, 3253, 3139, 3138, 3180, 3164, 3212, 3196, 3227, 3218, 3120, 3169, 3194, 3146] CNS-Medullo SBS18 C>G 1.0 0.0 0.52 0.37 1.0 1.0 0.016 6313.0 Lagging 1.405 1.0 0.52 0.0 1.0 [1, 1, 0, 0, 1, 1, 1, 0, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 0, 0, 0, 1, 1, 0, 0, 0, 1, 1, 1, 1, 0, 0, 1, 0, 1, 0, 1, 0, 1, 1, 0, 0, 0, 1, 1, 1, 1, 0, 0, 1, 0, 1, 1, 0, 0, 0, 0, 0, 1, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 1, 0, 1, 0, 1, 1, 0, 1, 0, 0, 0, 0, 1, 1, 0, 0, 1, 1, 1, 1, 0, 1, 0, 1, 1] 0.0 0.37 0.0 1.0 [0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 1, 1, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 1, 1, 1, 1, 1, 0, 1, 0, 0, 1, 0, 1, 1, 1, 1, 1, 0, 0, 1, 1, 0, 0, 1, 0, 1, 0, 0, 0, 0, 1, 1, 1, 1, 0, 0, 1, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0] CNS-Medullo SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6313.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] CNS-Medullo SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6313.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] CNS-Medullo SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6313.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] CNS-Medullo SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6313.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ColoRect-AdenoCA SBS18 C>A 47728.0 46047.0 47511.95 47697.1 1.558411483663107e-05 7.627374697651266e-05 96.149 97531.0 Lagging 1.037 0.996 1.041 47728.0 47511.95 47143.0 47866.0 [47529, 47805, 47565, 47283, 47628, 47451, 47818, 47603, 47403, 47655, 47636, 47466, 47633, 47464, 47429, 47563, 47226, 47661, 47455, 47479, 47475, 47495, 47791, 47372, 47371, 47501, 47577, 47572, 47745, 47670, 47546, 47595, 47701, 47529, 47462, 47618, 47575, 47687, 47552, 47441, 47636, 47799, 47642, 47372, 47192, 47517, 47491, 47231, 47656, 47476, 47297, 47548, 47644, 47501, 47573, 47863, 47406, 47248, 47354, 47207, 47537, 47407, 47273, 47488, 47756, 47451, 47566, 47558, 47443, 47498, 47255, 47447, 47438, 47405, 47656, 47143, 47465, 47347, 47251, 47626, 47710, 47683, 47439, 47433, 47657, 47586, 47643, 47866, 47200, 47440, 47350, 47219, 47478, 47451, 47735, 47520, 47369, 47321, 47738, 47667] 46047.0 47697.1 47347.0 48054.0 [47576, 47433, 47646, 47863, 47573, 47846, 47622, 47571, 47832, 47635, 47625, 47693, 47474, 47860, 47695, 47727, 47892, 47553, 47594, 47648, 47806, 47580, 47490, 47832, 47771, 47602, 47741, 47551, 47412, 47633, 47606, 47435, 47642, 47640, 47701, 47435, 47790, 47615, 47579, 47899, 47599, 47347, 47548, 47874, 48053, 47713, 47758, 47880, 47579, 47883, 47833, 47582, 47515, 47779, 47668, 47472, 47762, 47958, 47948, 47907, 47624, 47763, 47940, 47845, 47464, 47717, 47603, 47588, 47724, 47713, 47821, 47837, 47781, 47743, 47546, 47848, 47819, 47946, 48036, 47611, 47615, 47427, 47928, 47766, 47542, 47576, 47523, 47525, 48037, 47702, 47819, 48054, 47841, 47720, 47478, 47696, 47840, 47787, 47557, 47532] ColoRect-AdenoCA SBS18 C>G 62.0 70.0 65.91 68.52 0.8061229953800977 1.0 0.135 97531.0 Leading 1.129 1.04 1.086 62.0 65.91 48.0 79.0 [78, 66, 56, 62, 79, 68, 68, 70, 65, 63, 62, 63, 65, 67, 70, 75, 69, 67, 73, 66, 77, 61, 65, 69, 66, 78, 62, 73, 62, 60, 61, 66, 65, 60, 60, 57, 65, 68, 67, 71, 61, 72, 69, 69, 66, 60, 61, 69, 62, 48, 59, 66, 76, 61, 71, 61, 64, 54, 62, 57, 68, 72, 53, 71, 61, 68, 71, 63, 63, 60, 65, 76, 56, 59, 75, 65, 64, 76, 67, 60, 71, 62, 74, 71, 59, 64, 69, 59, 67, 67, 65, 67, 60, 75, 73, 66, 76, 67, 63, 70] 70.0 68.52 51.0 85.0 [61, 69, 80, 70, 51, 69, 66, 68, 69, 74, 77, 77, 64, 73, 64, 59, 66, 68, 63, 65, 56, 73, 67, 72, 69, 58, 71, 65, 73, 74, 68, 67, 70, 76, 68, 75, 66, 72, 66, 60, 78, 62, 64, 72, 69, 71, 71, 68, 70, 85, 71, 65, 65, 76, 62, 71, 69, 81, 73, 80, 71, 64, 79, 56, 69, 67, 66, 75, 71, 74, 71, 60, 74, 75, 62, 68, 63, 62, 68, 75, 66, 73, 56, 63, 73, 69, 66, 74, 67, 66, 71, 72, 76, 59, 63, 67, 58, 68, 70, 63] ColoRect-AdenoCA SBS18 C>T 360.0 328.0 342.88 351.13 0.2818321630987517 0.6385295258979538 0.705 97531.0 Lagging 1.098 0.977 1.124 1 360.0 342.88 312.0 376.0 [334, 329, 354, 344, 328, 347, 346, 375, 335, 355, 342, 340, 352, 328, 339, 323, 348, 346, 350, 359, 343, 340, 336, 342, 312, 359, 344, 334, 352, 336, 326, 357, 344, 326, 330, 346, 355, 333, 332, 331, 342, 362, 360, 347, 332, 341, 364, 329, 354, 332, 330, 357, 347, 349, 335, 366, 342, 354, 376, 347, 316, 351, 337, 329, 336, 357, 360, 332, 365, 356, 367, 338, 312, 319, 344, 339, 358, 338, 314, 335, 337, 336, 342, 345, 353, 351, 330, 318, 360, 351, 338, 348, 322, 346, 333, 372, 349, 323, 352, 361] 328.0 351.13 310.0 379.0 [368, 355, 342, 357, 362, 345, 344, 329, 367, 344, 362, 361, 339, 354, 359, 372, 354, 349, 346, 340, 344, 344, 353, 362, 364, 327, 353, 368, 330, 372, 362, 336, 343, 361, 367, 365, 347, 360, 353, 365, 362, 327, 339, 351, 364, 345, 323, 366, 334, 368, 360, 349, 338, 355, 347, 335, 350, 333, 310, 348, 356, 342, 353, 362, 362, 351, 337, 358, 340, 348, 321, 367, 366, 379, 339, 347, 339, 346, 364, 360, 355, 350, 350, 353, 339, 345, 360, 372, 323, 349, 349, 353, 372, 353, 360, 332, 358, 376, 357, 341] ColoRect-AdenoCA SBS18 T>A 1213.0 1284.0 1283.52 1247.7 0.13490243070131847 0.36489525355567254 2.56 97531.0 Leading 1.059 0.972 1.089 1213.0 1283.52 1224.0 1348.0 [1254, 1290, 1262, 1305, 1282, 1250, 1262, 1280, 1269, 1287, 1262, 1260, 1287, 1271, 1255, 1272, 1261, 1295, 1270, 1292, 1277, 1271, 1258, 1267, 1265, 1227, 1263, 1277, 1321, 1279, 1302, 1296, 1304, 1286, 1243, 1322, 1337, 1272, 1272, 1263, 1243, 1249, 1314, 1269, 1300, 1231, 1319, 1333, 1304, 1255, 1314, 1295, 1348, 1232, 1255, 1238, 1288, 1280, 1304, 1283, 1307, 1243, 1240, 1310, 1273, 1277, 1311, 1262, 1325, 1342, 1279, 1314, 1272, 1280, 1288, 1288, 1329, 1290, 1293, 1288, 1319, 1281, 1312, 1296, 1303, 1296, 1224, 1317, 1278, 1315, 1249, 1289, 1264, 1301, 1304, 1309, 1296, 1281, 1298, 1287] 1284.0 1247.7 1169.0 1304.0 [1286, 1261, 1285, 1250, 1265, 1291, 1253, 1254, 1259, 1247, 1282, 1282, 1242, 1253, 1268, 1275, 1269, 1258, 1279, 1248, 1255, 1268, 1259, 1268, 1239, 1300, 1271, 1248, 1216, 1238, 1219, 1222, 1235, 1248, 1294, 1215, 1179, 1241, 1253, 1277, 1261, 1300, 1207, 1260, 1208, 1287, 1213, 1169, 1242, 1254, 1231, 1248, 1189, 1278, 1274, 1273, 1236, 1232, 1251, 1227, 1224, 1304, 1299, 1203, 1248, 1240, 1213, 1249, 1196, 1202, 1232, 1230, 1279, 1245, 1281, 1211, 1244, 1238, 1243, 1213, 1238, 1260, 1261, 1241, 1242, 1218, 1300, 1230, 1241, 1214, 1267, 1222, 1294, 1235, 1246, 1212, 1215, 1263, 1238, 1247] ColoRect-AdenoCA SBS18 T>C 61.0 77.0 68.45 66.86 0.33133166491490396 0.715942475182281 0.141 97531.0 Leading 1.262 0.977 1.292 1 1 61.0 68.45 53.0 88.0 [68, 75, 78, 70, 64, 71, 72, 66, 58, 67, 71, 76, 65, 74, 70, 68, 62, 68, 69, 70, 69, 68, 67, 61, 68, 66, 61, 76, 69, 66, 67, 70, 65, 68, 70, 70, 71, 62, 63, 74, 65, 63, 65, 81, 76, 65, 71, 68, 68, 67, 68, 80, 72, 70, 68, 72, 53, 71, 75, 59, 88, 72, 69, 63, 63, 74, 79, 70, 66, 66, 76, 65, 63, 70, 73, 59, 72, 63, 64, 64, 70, 53, 69, 72, 72, 65, 72, 78, 60, 74, 64, 73, 59, 68, 77, 67, 66, 70, 58, 69] 77.0 66.86 46.0 82.0 [68, 62, 61, 65, 71, 62, 65, 73, 75, 65, 66, 62, 72, 66, 67, 69, 71, 66, 68, 66, 73, 72, 74, 70, 66, 66, 68, 59, 67, 65, 71, 68, 70, 62, 67, 64, 65, 75, 72, 69, 72, 70, 72, 51, 62, 67, 59, 66, 62, 69, 72, 58, 62, 63, 67, 63, 82, 65, 61, 79, 46, 63, 65, 72, 65, 60, 59, 67, 68, 72, 61, 69, 70, 62, 71, 77, 62, 71, 70, 72, 70, 81, 67, 61, 61, 71, 64, 59, 68, 65, 66, 63, 66, 66, 61, 69, 72, 67, 80, 62] ColoRect-AdenoCA SBS18 T>G 150.0 151.0 157.94 149.28 0.7456326228781607 1.0 0.309 97531.0 Leading 1.007 0.945 1.065 150.0 157.94 136.0 190.0 [153, 152, 146, 146, 161, 157, 144, 164, 153, 145, 144, 147, 153, 157, 170, 167, 159, 159, 163, 161, 143, 175, 160, 148, 157, 160, 163, 149, 148, 150, 154, 164, 164, 168, 159, 157, 149, 159, 160, 154, 171, 172, 157, 147, 154, 173, 154, 155, 136, 182, 160, 147, 156, 170, 146, 138, 161, 156, 161, 156, 147, 154, 190, 168, 161, 154, 142, 156, 155, 172, 166, 162, 162, 169, 167, 161, 164, 167, 158, 167, 146, 160, 154, 156, 165, 159, 147, 167, 164, 147, 156, 188, 159, 158, 155, 151, 154, 146, 163, 163] 151.0 149.28 121.0 168.0 [147, 153, 164, 153, 144, 156, 159, 150, 160, 165, 165, 158, 156, 156, 137, 146, 150, 148, 138, 145, 163, 134, 143, 156, 147, 147, 144, 160, 155, 152, 152, 131, 145, 146, 143, 142, 155, 152, 145, 159, 133, 143, 147, 164, 162, 143, 153, 151, 168, 124, 143, 158, 155, 137, 167, 163, 143, 149, 144, 156, 154, 151, 121, 140, 150, 149, 160, 148, 156, 135, 142, 133, 148, 144, 141, 140, 149, 145, 137, 146, 168, 149, 150, 156, 146, 143, 154, 138, 148, 158, 152, 128, 148, 152, 164, 162, 145, 162, 143, 149] ESCC SBS18 C>A 159690.0 153408.0 158289.02 158900.41 2.612959746943808e-18 2.095745784259189e-17 99.752 313876.0 Lagging 1.041 0.996 1.045 159690.0 158289.02 157411.0 159017.0 [158859, 157695, 158495, 158337, 158858, 157806, 158485, 158576, 158275, 158247, 158337, 158150, 157896, 158277, 158577, 158144, 158370, 158448, 157853, 158349, 158020, 158710, 157925, 158323, 158081, 158248, 157845, 158079, 157932, 158417, 158561, 158614, 158337, 158502, 157979, 158123, 158168, 158205, 158888, 157849, 157411, 158841, 158309, 158287, 158842, 158503, 158160, 158549, 158587, 158479, 157824, 158088, 158463, 158056, 158173, 158119, 158246, 158266, 157776, 158565, 158738, 158252, 158080, 158138, 158403, 158601, 157926, 158079, 158378, 158095, 158160, 157998, 158249, 158425, 158449, 158483, 157901, 158639, 158114, 158431, 158439, 158488, 158206, 158656, 158544, 158649, 158436, 157874, 158439, 158056, 157834, 158011, 158914, 158070, 158178, 159017, 158448, 158284, 158241, 158195] 153408.0 158900.41 158237.0 159434.0 [158522, 159237, 158850, 158793, 158630, 159001, 158820, 158548, 158975, 159018, 158717, 159097, 159308, 158751, 158394, 159224, 159096, 158684, 159292, 158801, 159194, 158656, 159217, 158723, 159214, 159155, 159132, 158979, 159216, 158908, 158589, 158665, 158879, 158615, 159101, 158850, 159300, 158582, 158371, 159063, 159434, 158398, 158993, 159152, 158545, 158637, 158993, 158746, 158607, 158614, 159295, 159110, 158680, 158994, 158961, 159077, 159167, 159038, 159353, 158604, 158295, 159030, 159154, 158833, 158515, 158647, 158928, 159352, 158686, 159214, 159000, 159200, 158885, 158785, 158641, 158793, 159180, 159098, 158969, 158915, 158721, 158852, 159217, 158581, 158770, 158543, 158818, 159024, 158657, 159321, 159086, 159303, 158419, 159059, 159119, 158237, 158733, 159002, 158883, 159011] ESCC SBS18 C>G 61.0 72.0 64.26 65.67 0.6208381509912453 1.0 0.042 313876.0 Leading 1.18 1.022 1.155 1 61.0 64.26 48.0 78.0 [64, 62, 64, 65, 63, 65, 72, 62, 63, 62, 65, 63, 64, 61, 68, 65, 55, 70, 71, 61, 64, 66, 68, 61, 62, 63, 72, 57, 59, 68, 61, 78, 62, 67, 57, 71, 67, 62, 61, 63, 68, 65, 65, 48, 69, 60, 62, 67, 60, 64, 56, 64, 59, 66, 72, 72, 63, 68, 69, 69, 58, 65, 61, 60, 69, 71, 64, 59, 68, 58, 67, 62, 59, 61, 61, 63, 60, 68, 68, 68, 69, 68, 60, 70, 67, 67, 56, 53, 73, 69, 72, 68, 67, 67, 61, 55, 62, 71, 63, 58] 72.0 65.67 54.0 76.0 [64, 67, 63, 67, 68, 65, 58, 72, 71, 65, 66, 66, 67, 67, 63, 62, 74, 64, 64, 68, 62, 65, 59, 65, 61, 68, 59, 71, 70, 67, 71, 55, 66, 62, 73, 55, 60, 68, 74, 66, 68, 55, 62, 76, 62, 75, 66, 61, 71, 66, 66, 68, 73, 65, 60, 59, 72, 62, 56, 63, 73, 70, 73, 67, 62, 65, 68, 69, 67, 74, 62, 68, 73, 64, 69, 61, 67, 55, 65, 68, 67, 63, 68, 59, 66, 63, 76, 73, 54, 63, 58, 60, 62, 64, 73, 66, 66, 62, 69, 71] ESCC SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 313876.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS18 T>A 289.0 324.0 313.91 306.81 0.2319862374746946 0.5514674946784862 0.195 313876.0 Leading 1.121 0.977 1.147 1 289.0 313.91 287.0 354.0 [318, 336, 317, 313, 302, 304, 298, 307, 308, 328, 287, 330, 330, 299, 302, 316, 338, 302, 319, 312, 314, 328, 329, 326, 291, 312, 329, 296, 306, 305, 326, 308, 292, 298, 311, 321, 302, 323, 329, 337, 290, 302, 293, 307, 316, 295, 313, 307, 327, 333, 320, 312, 306, 343, 312, 325, 316, 309, 312, 324, 318, 319, 314, 346, 307, 322, 310, 331, 326, 326, 326, 289, 323, 354, 296, 312, 327, 321, 313, 308, 318, 298, 319, 326, 317, 303, 312, 320, 309, 300, 297, 307, 289, 316, 302, 300, 312, 303, 318, 326] 324.0 306.81 272.0 338.0 [298, 282, 305, 312, 314, 311, 329, 316, 314, 280, 335, 294, 301, 325, 322, 306, 287, 309, 313, 306, 306, 300, 294, 292, 327, 300, 300, 332, 319, 313, 299, 310, 333, 322, 307, 315, 315, 296, 288, 281, 332, 315, 323, 312, 297, 328, 309, 321, 296, 296, 313, 305, 316, 276, 309, 283, 304, 306, 307, 292, 302, 301, 301, 276, 313, 298, 319, 287, 301, 294, 291, 318, 295, 272, 327, 308, 293, 306, 310, 316, 290, 328, 305, 307, 302, 321, 306, 302, 309, 309, 324, 307, 338, 309, 310, 308, 316, 322, 302, 290] ESCC SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 313876.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS18 T>G 18.0 14.0 14.95 14.0 0.7957781361094145 1.0 0.01 313876.0 Lagging 1.286 1.068 1.204 1 1 18.0 14.95 8.0 22.0 [13, 15, 12, 17, 9, 17, 16, 14, 8, 15, 18, 12, 16, 18, 14, 16, 17, 14, 14, 14, 14, 12, 15, 13, 17, 17, 14, 15, 9, 14, 19, 18, 14, 17, 15, 16, 15, 16, 12, 15, 14, 13, 17, 12, 15, 13, 18, 15, 15, 19, 16, 15, 20, 20, 11, 13, 22, 22, 16, 15, 13, 15, 17, 12, 14, 16, 15, 16, 16, 13, 15, 13, 9, 15, 13, 15, 12, 12, 10, 21, 16, 17, 16, 15, 11, 18, 16, 8, 19, 17, 22, 12, 12, 10, 20, 17, 11, 15, 17, 17] 14.0 14.0 7.0 21.0 [16, 11, 17, 15, 18, 13, 13, 16, 19, 14, 13, 17, 11, 13, 17, 7, 10, 14, 14, 13, 15, 18, 16, 16, 11, 13, 17, 15, 21, 17, 12, 11, 13, 13, 13, 12, 13, 14, 18, 13, 17, 18, 13, 18, 12, 16, 11, 15, 15, 10, 12, 15, 11, 8, 16, 16, 9, 9, 15, 12, 14, 11, 9, 16, 15, 11, 16, 14, 13, 16, 11, 17, 18, 13, 17, 11, 17, 17, 18, 9, 12, 12, 15, 14, 15, 12, 15, 21, 12, 10, 9, 19, 20, 16, 11, 14, 15, 13, 10, 12] Eso-AdenoCA SBS18 C>A 46323.0 45175.0 46257.94 46384.81 0.0028543860508476113 0.011200491930773908 97.222 94112.0 Lagging 1.025 0.997 1.028 46323.0 46257.94 45851.0 46668.0 [46337, 46374, 46200, 46351, 46372, 46025, 46043, 45976, 46354, 46200, 46268, 46198, 46621, 46273, 46124, 46500, 46438, 46199, 46115, 46162, 46529, 46200, 46213, 46274, 46318, 46215, 46161, 46178, 46500, 46345, 46638, 46174, 46465, 46198, 46116, 46390, 46112, 45857, 46294, 46232, 46208, 46237, 46382, 46130, 46147, 46255, 46197, 46329, 46175, 46221, 46161, 46288, 46244, 46134, 46372, 46145, 46397, 46450, 46184, 46147, 46170, 46337, 46068, 46063, 46302, 46069, 46231, 45950, 46429, 46262, 46504, 46428, 45891, 46376, 46101, 46383, 46343, 46197, 45851, 46338, 46668, 46268, 46167, 46259, 46403, 46316, 46347, 46283, 46082, 46237, 46492, 46271, 46238, 46356, 46337, 46428, 46332, 46109, 46116, 46450] 45175.0 46384.81 45921.0 46737.0 [46356, 46320, 46318, 46250, 46219, 46434, 46398, 46651, 46291, 46562, 46563, 46509, 46013, 46339, 46533, 46176, 46184, 46503, 46619, 46584, 46156, 46464, 46490, 46386, 46469, 46636, 46455, 46630, 46098, 46258, 45921, 46339, 46094, 46562, 46517, 46171, 46538, 46737, 46301, 46409, 46461, 46426, 46312, 46457, 46605, 46353, 46594, 46377, 46396, 46420, 46375, 46287, 46434, 46458, 46342, 46465, 46231, 46165, 46464, 46474, 46434, 46298, 46537, 46522, 46279, 46561, 46294, 46647, 46170, 46520, 46182, 46220, 46607, 46201, 46437, 46132, 46339, 46574, 46667, 46433, 46026, 46476, 46445, 46212, 46438, 46374, 46415, 46319, 46539, 46254, 46254, 46368, 46413, 46278, 46360, 46155, 46299, 46495, 46525, 46233] Eso-AdenoCA SBS18 C>G 58.0 57.0 57.61 55.8 1.0 1.0 0.122 94112.0 Lagging 1.018 1.032 0.986 58.0 57.61 47.0 70.0 [56, 52, 47, 57, 66, 69, 56, 64, 55, 50, 59, 64, 58, 52, 58, 69, 51, 62, 64, 63, 61, 61, 65, 58, 63, 55, 62, 51, 65, 56, 55, 55, 52, 57, 57, 48, 54, 55, 51, 59, 63, 61, 68, 65, 58, 52, 56, 59, 66, 51, 53, 63, 58, 62, 64, 50, 52, 50, 59, 59, 53, 70, 55, 63, 47, 61, 68, 49, 62, 59, 51, 53, 56, 54, 64, 50, 56, 58, 65, 57, 54, 60, 60, 60, 50, 69, 61, 60, 52, 54, 53, 49, 53, 59, 57, 52, 58, 55, 58, 55] 57.0 55.8 42.0 66.0 [60, 60, 64, 54, 48, 45, 55, 50, 54, 66, 54, 48, 56, 63, 51, 42, 64, 53, 49, 51, 54, 53, 47, 58, 47, 59, 50, 63, 48, 56, 53, 60, 60, 58, 63, 64, 56, 49, 63, 56, 56, 51, 49, 52, 55, 58, 58, 52, 51, 60, 61, 51, 56, 47, 50, 60, 60, 66, 55, 52, 61, 43, 60, 53, 66, 55, 46, 61, 60, 53, 63, 59, 61, 57, 51, 64, 53, 51, 50, 60, 57, 52, 51, 55, 65, 48, 54, 52, 63, 58, 62, 60, 62, 52, 58, 59, 60, 61, 56, 64] Eso-AdenoCA SBS18 C>T 389.0 343.0 358.28 367.65 0.15719205709681186 0.41101976798960455 0.778 94112.0 Lagging 1.134 0.975 1.164 1 389.0 358.28 324.0 399.0 [351, 358, 337, 369, 368, 385, 368, 367, 366, 358, 372, 345, 348, 349, 356, 335, 353, 344, 362, 357, 368, 355, 367, 367, 359, 364, 347, 329, 374, 360, 367, 348, 355, 376, 372, 372, 360, 399, 359, 372, 371, 352, 367, 349, 353, 350, 352, 366, 337, 355, 369, 362, 338, 352, 348, 336, 365, 363, 361, 360, 355, 378, 357, 374, 331, 393, 346, 348, 349, 366, 343, 358, 345, 371, 344, 389, 383, 324, 350, 350, 366, 348, 345, 338, 354, 353, 369, 344, 389, 357, 367, 345, 376, 353, 353, 358, 369, 355, 348, 363] 343.0 367.65 331.0 410.0 [372, 371, 388, 359, 368, 361, 357, 363, 371, 368, 350, 391, 395, 366, 380, 369, 360, 371, 357, 361, 366, 369, 368, 374, 358, 353, 379, 389, 359, 367, 377, 366, 364, 362, 358, 355, 366, 332, 355, 350, 348, 374, 357, 375, 382, 385, 377, 372, 384, 365, 360, 371, 369, 359, 366, 395, 373, 361, 369, 372, 370, 343, 370, 350, 387, 331, 374, 382, 380, 347, 380, 371, 380, 360, 383, 347, 337, 410, 372, 376, 373, 375, 388, 375, 377, 364, 351, 372, 348, 368, 363, 374, 356, 371, 367, 359, 366, 374, 371, 364] Eso-AdenoCA SBS18 T>A 589.0 623.0 614.83 602.49 0.3509048326391821 0.7434055964862113 1.288 94112.0 Leading 1.058 0.98 1.079 589.0 614.83 563.0 677.0 [623, 644, 606, 650, 650, 577, 625, 636, 603, 592, 647, 620, 625, 628, 614, 627, 594, 565, 625, 616, 635, 618, 600, 592, 628, 630, 575, 606, 622, 610, 616, 644, 639, 627, 604, 609, 607, 599, 606, 589, 592, 591, 614, 614, 612, 616, 641, 593, 600, 616, 617, 631, 677, 604, 650, 578, 586, 614, 641, 578, 601, 611, 615, 625, 606, 627, 618, 563, 618, 622, 601, 623, 596, 593, 636, 631, 600, 630, 642, 604, 613, 606, 637, 602, 613, 613, 607, 616, 623, 631, 637, 603, 615, 635, 594, 603, 628, 628, 616, 613] 623.0 602.49 540.0 660.0 [602, 562, 609, 565, 579, 634, 613, 570, 607, 640, 571, 594, 592, 572, 597, 595, 597, 633, 594, 605, 579, 601, 605, 627, 597, 598, 660, 617, 618, 595, 620, 573, 584, 579, 604, 601, 600, 619, 616, 623, 635, 622, 597, 598, 606, 616, 575, 611, 631, 609, 593, 608, 540, 619, 585, 632, 629, 598, 594, 642, 624, 606, 611, 602, 620, 587, 612, 643, 602, 613, 635, 593, 599, 607, 568, 591, 616, 581, 591, 617, 589, 604, 586, 600, 611, 605, 600, 615, 590, 573, 593, 604, 597, 582, 611, 608, 584, 587, 597, 608] Eso-AdenoCA SBS18 T>C 92.0 65.0 79.56 76.86 0.21077308887663612 0.5133029473993337 0.167 94112.0 Lagging 1.415 1.035 1.367 1 1 1 92.0 79.56 63.0 99.0 [76, 80, 79, 74, 80, 76, 74, 64, 74, 78, 82, 87, 84, 74, 77, 68, 99, 88, 89, 88, 85, 81, 83, 82, 79, 73, 88, 88, 73, 85, 73, 81, 73, 70, 69, 82, 70, 74, 83, 83, 74, 82, 80, 88, 80, 73, 83, 90, 80, 88, 86, 73, 76, 68, 88, 78, 85, 89, 77, 78, 74, 86, 73, 80, 79, 80, 70, 78, 78, 80, 76, 78, 76, 84, 86, 90, 97, 77, 97, 79, 71, 78, 73, 76, 79, 77, 85, 83, 75, 83, 72, 81, 79, 81, 90, 71, 82, 63, 77, 80] 65.0 76.86 59.0 94.0 [74, 79, 79, 84, 77, 81, 84, 82, 82, 77, 73, 73, 72, 85, 77, 89, 59, 65, 70, 63, 69, 79, 72, 67, 76, 77, 68, 67, 88, 73, 79, 81, 80, 83, 92, 76, 83, 82, 72, 76, 84, 75, 73, 70, 72, 84, 72, 72, 79, 71, 72, 84, 86, 83, 70, 75, 71, 65, 78, 88, 84, 75, 82, 76, 78, 71, 82, 78, 81, 78, 83, 76, 83, 74, 65, 70, 62, 78, 61, 74, 88, 80, 81, 75, 78, 79, 76, 77, 76, 73, 87, 75, 81, 76, 72, 82, 76, 94, 84, 76] Eso-AdenoCA SBS18 T>G 213.0 185.0 208.07 201.71 0.4810565419398905 0.9102311334191218 0.423 94112.0 Lagging 1.151 1.032 1.116 1 213.0 208.07 182.0 232.0 [209, 211, 196, 210, 218, 197, 206, 222, 203, 220, 212, 222, 201, 218, 209, 200, 209, 202, 218, 206, 215, 209, 196, 206, 197, 216, 195, 193, 213, 221, 204, 207, 211, 207, 216, 212, 201, 212, 189, 200, 213, 211, 228, 209, 212, 220, 201, 201, 194, 207, 200, 183, 205, 202, 182, 208, 214, 232, 207, 209, 204, 223, 218, 194, 202, 222, 195, 220, 213, 194, 214, 222, 199, 194, 206, 195, 207, 205, 223, 193, 217, 219, 208, 216, 228, 199, 207, 214, 221, 190, 216, 209, 206, 211, 216, 219, 195, 215, 212, 199] 185.0 201.71 173.0 231.0 [195, 201, 207, 200, 182, 214, 201, 176, 207, 193, 197, 188, 219, 202, 196, 198, 199, 214, 196, 196, 204, 200, 207, 200, 212, 192, 206, 226, 198, 191, 208, 202, 203, 204, 200, 191, 212, 195, 219, 204, 198, 207, 188, 203, 206, 189, 202, 205, 213, 204, 219, 231, 203, 214, 227, 207, 203, 173, 212, 206, 193, 193, 194, 196, 210, 192, 220, 203, 200, 215, 190, 187, 212, 209, 205, 213, 202, 199, 181, 222, 201, 194, 199, 196, 187, 199, 201, 196, 189, 220, 203, 203, 197, 206, 184, 192, 209, 193, 193, 208] Head-SCC SBS18 C>A 5332.0 5349.0 5393.41 5438.17 0.8592942129315113 1.0 100.0 10681.0 Leading 1.003 1.008 0.995 5332.0 5393.41 5274.0 5533.0 [5400, 5379, 5378, 5323, 5364, 5447, 5358, 5387, 5403, 5386, 5306, 5400, 5363, 5408, 5320, 5412, 5342, 5395, 5412, 5366, 5422, 5450, 5274, 5383, 5397, 5327, 5315, 5449, 5393, 5366, 5474, 5389, 5431, 5435, 5413, 5429, 5472, 5358, 5399, 5389, 5372, 5405, 5305, 5398, 5445, 5414, 5382, 5371, 5463, 5429, 5349, 5291, 5375, 5382, 5364, 5393, 5361, 5358, 5427, 5492, 5405, 5428, 5371, 5435, 5338, 5439, 5470, 5417, 5360, 5400, 5419, 5402, 5385, 5435, 5402, 5422, 5430, 5358, 5323, 5446, 5334, 5359, 5396, 5413, 5311, 5359, 5432, 5384, 5395, 5377, 5453, 5371, 5349, 5427, 5383, 5424, 5399, 5533, 5510, 5357] 5349.0 5438.17 5322.0 5546.0 [5451, 5493, 5486, 5513, 5466, 5414, 5425, 5451, 5401, 5485, 5509, 5454, 5491, 5452, 5452, 5399, 5495, 5437, 5461, 5452, 5366, 5407, 5523, 5421, 5458, 5519, 5546, 5400, 5385, 5461, 5375, 5423, 5398, 5411, 5424, 5379, 5411, 5457, 5418, 5412, 5468, 5478, 5498, 5468, 5427, 5388, 5418, 5424, 5405, 5441, 5503, 5452, 5418, 5420, 5442, 5476, 5487, 5443, 5408, 5335, 5451, 5387, 5447, 5447, 5471, 5366, 5375, 5411, 5475, 5449, 5430, 5463, 5496, 5377, 5406, 5389, 5411, 5472, 5477, 5447, 5493, 5458, 5473, 5393, 5494, 5476, 5389, 5435, 5449, 5387, 5404, 5449, 5509, 5379, 5468, 5413, 5356, 5346, 5322, 5497] Head-SCC SBS18 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10681.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10681.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10681.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10681.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Head-SCC SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 10681.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS18 C>A 1909.0 1950.0 1943.7 1957.19 0.7678656368873019 1.0 100.0 3859.0 Leading 1.021 1.007 1.014 1909.0 1943.7 1875.0 2008.0 [1906, 1980, 1888, 1946, 1955, 1903, 1931, 1987, 1928, 1970, 1955, 1951, 1891, 1978, 1971, 1898, 1981, 1953, 1990, 1907, 1927, 1932, 1925, 1971, 1922, 1960, 2007, 1949, 1998, 1953, 1978, 1948, 1987, 1975, 1921, 1893, 2005, 1968, 1953, 1999, 1924, 1894, 1889, 1994, 1955, 1986, 1924, 1875, 1946, 1955, 1914, 1958, 1942, 1969, 2008, 1927, 1972, 1977, 1922, 1886, 1967, 1943, 1960, 2005, 1898, 1947, 1925, 1956, 1918, 1937, 1952, 1898, 1887, 1927, 1941, 1927, 1931, 1930, 1913, 1941, 1963, 1908, 1921, 1946, 1964, 1961, 1971, 1915, 1967, 1925, 1974, 1964, 1944, 1895, 1908, 1899, 1949, 1966, 1915, 1955] 1950.0 1957.19 1884.0 2050.0 [1967, 1916, 1989, 1947, 1955, 1982, 1987, 1920, 2002, 1929, 1964, 1950, 2019, 1907, 1945, 2007, 1923, 1969, 1941, 1993, 1947, 1992, 1963, 1947, 1976, 1963, 1914, 1943, 1922, 1974, 1919, 1932, 1922, 1927, 1958, 2000, 1893, 1918, 1957, 1884, 1975, 2011, 2030, 1923, 1942, 1911, 1965, 1992, 1957, 1942, 1974, 1948, 1958, 1919, 1886, 1956, 1909, 1954, 1958, 2050, 1935, 1938, 1956, 1918, 2003, 1958, 1972, 1948, 1974, 1977, 1938, 1980, 1994, 2001, 1987, 1981, 1962, 1992, 2010, 1974, 1938, 1956, 1975, 1950, 1936, 1929, 1928, 1969, 1920, 2006, 1920, 1935, 1954, 2002, 1986, 1972, 1953, 1938, 1969, 1962] Liver-HCC SBS18 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3859.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3859.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3859.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3859.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Liver-HCC SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3859.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS18 C>A 1173.0 1217.0 1203.44 1191.57 0.41832821053230657 0.8377684046120143 100.0 2390.0 Leading 1.038 0.99 1.048 1173.0 1203.44 1138.0 1286.0 [1229, 1235, 1181, 1176, 1221, 1235, 1211, 1195, 1188, 1253, 1186, 1208, 1236, 1203, 1202, 1207, 1190, 1189, 1182, 1165, 1181, 1253, 1235, 1172, 1242, 1213, 1177, 1208, 1190, 1232, 1215, 1192, 1201, 1188, 1202, 1195, 1164, 1213, 1202, 1253, 1160, 1203, 1241, 1189, 1197, 1143, 1204, 1206, 1232, 1158, 1138, 1286, 1211, 1146, 1207, 1248, 1218, 1176, 1204, 1197, 1208, 1189, 1189, 1199, 1156, 1198, 1235, 1204, 1215, 1210, 1198, 1198, 1203, 1232, 1233, 1198, 1231, 1184, 1193, 1184, 1251, 1238, 1190, 1182, 1219, 1191, 1197, 1246, 1206, 1204, 1209, 1185, 1209, 1182, 1185, 1198, 1235, 1228, 1188, 1160] 1217.0 1191.57 1135.0 1250.0 [1173, 1192, 1190, 1205, 1202, 1171, 1172, 1199, 1206, 1145, 1178, 1178, 1165, 1186, 1174, 1199, 1218, 1204, 1211, 1229, 1219, 1147, 1182, 1210, 1173, 1200, 1197, 1186, 1210, 1174, 1211, 1210, 1216, 1199, 1189, 1215, 1231, 1189, 1157, 1142, 1250, 1192, 1155, 1187, 1189, 1246, 1205, 1184, 1188, 1220, 1213, 1135, 1178, 1226, 1180, 1145, 1159, 1199, 1179, 1203, 1173, 1202, 1200, 1197, 1245, 1203, 1169, 1180, 1174, 1190, 1185, 1187, 1219, 1167, 1154, 1194, 1165, 1196, 1219, 1231, 1157, 1165, 1203, 1206, 1176, 1192, 1194, 1163, 1206, 1189, 1187, 1220, 1186, 1186, 1192, 1212, 1166, 1201, 1194, 1225] Lung-AdenoCA SBS18 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2390.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2390.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2390.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2390.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2390.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS18 C>A 1883.0 1796.0 1856.75 1858.54 0.3060628342656385 0.6775385805304314 100.0 3679.0 Lagging 1.048 0.999 1.049 1883.0 1856.75 1751.0 1938.0 [1871, 1826, 1896, 1904, 1854, 1838, 1873, 1868, 1938, 1845, 1908, 1852, 1819, 1865, 1894, 1929, 1932, 1803, 1812, 1910, 1932, 1884, 1812, 1830, 1813, 1834, 1871, 1856, 1834, 1847, 1825, 1887, 1854, 1835, 1796, 1869, 1872, 1849, 1879, 1858, 1866, 1884, 1887, 1839, 1867, 1889, 1812, 1847, 1877, 1808, 1789, 1876, 1851, 1818, 1789, 1872, 1868, 1863, 1833, 1814, 1833, 1856, 1893, 1751, 1844, 1845, 1905, 1900, 1857, 1881, 1862, 1807, 1850, 1895, 1850, 1832, 1869, 1878, 1834, 1880, 1850, 1889, 1895, 1842, 1838, 1796, 1840, 1819, 1827, 1816, 1843, 1875, 1880, 1928, 1858, 1854, 1844, 1876, 1893, 1867] 1796.0 1858.54 1780.0 1949.0 [1873, 1883, 1864, 1828, 1869, 1858, 1871, 1848, 1807, 1873, 1832, 1866, 1901, 1852, 1849, 1810, 1780, 1912, 1877, 1790, 1800, 1835, 1914, 1892, 1883, 1894, 1863, 1853, 1910, 1871, 1885, 1824, 1862, 1869, 1881, 1824, 1851, 1868, 1810, 1870, 1855, 1820, 1809, 1874, 1848, 1830, 1883, 1876, 1828, 1912, 1908, 1827, 1888, 1896, 1894, 1840, 1864, 1843, 1845, 1886, 1861, 1835, 1844, 1949, 1866, 1902, 1840, 1809, 1837, 1851, 1856, 1910, 1891, 1833, 1867, 1855, 1856, 1827, 1894, 1831, 1841, 1827, 1803, 1834, 1882, 1920, 1870, 1899, 1889, 1882, 1855, 1829, 1831, 1803, 1880, 1840, 1872, 1862, 1833, 1860] Ovary-AdenoCA SBS18 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3679.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3679.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3679.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3679.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Ovary-AdenoCA SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 3679.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS18 C>A 17925.0 17309.0 17795.45 17828.97 0.014307117847626031 0.050369077506548836 100.0 35234.0 Lagging 1.036 0.998 1.038 17925.0 17795.45 17494.0 17996.0 [17728, 17853, 17872, 17845, 17676, 17786, 17855, 17810, 17811, 17879, 17819, 17775, 17722, 17794, 17807, 17836, 17641, 17819, 17840, 17900, 17831, 17816, 17899, 17852, 17830, 17765, 17632, 17951, 17719, 17889, 17767, 17715, 17742, 17786, 17766, 17564, 17808, 17996, 17739, 17720, 17879, 17600, 17786, 17899, 17872, 17765, 17849, 17797, 17705, 17812, 17666, 17805, 17880, 17863, 17494, 17957, 17982, 17764, 17907, 17715, 17645, 17755, 17769, 17883, 17868, 17823, 17754, 17630, 17764, 17792, 17743, 17829, 17919, 17746, 17869, 17911, 17707, 17964, 17754, 17676, 17724, 17858, 17798, 17969, 17859, 17746, 17739, 17865, 17831, 17787, 17823, 17643, 17785, 17593, 17948, 17645, 17923, 17749, 17851, 17756] 17309.0 17828.97 17609.0 18115.0 [17859, 17764, 17835, 17730, 17978, 17865, 17738, 17786, 17832, 17794, 17832, 17805, 17820, 17832, 17840, 17827, 18058, 17841, 17850, 17693, 17765, 17829, 17761, 17782, 17760, 17869, 17873, 17725, 17865, 17758, 17816, 17778, 17925, 17948, 17883, 18081, 17800, 17663, 17903, 17814, 17800, 18055, 17726, 17776, 17763, 17869, 17846, 17838, 17940, 17786, 18012, 17888, 17822, 17670, 18115, 17735, 17720, 17813, 17672, 17801, 17989, 17861, 17817, 17657, 17733, 17799, 17848, 18036, 17908, 17733, 17832, 17772, 17609, 17863, 17889, 17768, 17909, 17675, 17787, 17917, 17977, 17835, 17760, 17725, 17780, 17952, 17912, 17660, 17749, 17800, 17849, 17966, 17804, 17995, 17714, 17966, 17693, 17782, 17873, 17879] Panc-AdenoCA SBS18 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 35234.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 35234.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 35234.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 35234.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 35234.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Prost-AdenoCA SBS18 C>A 2636.0 2426.0 2551.56 2563.05 0.02772700769175421 0.09229540910884075 100.0 5062.0 Lagging 1.087 0.996 1.091 2636.0 2551.56 2460.0 2639.0 [2563, 2503, 2531, 2594, 2506, 2475, 2563, 2563, 2602, 2573, 2537, 2569, 2507, 2609, 2470, 2618, 2545, 2627, 2583, 2573, 2512, 2554, 2537, 2555, 2574, 2547, 2491, 2516, 2581, 2574, 2563, 2502, 2557, 2539, 2537, 2535, 2574, 2460, 2562, 2571, 2530, 2528, 2580, 2595, 2558, 2582, 2519, 2491, 2542, 2543, 2540, 2540, 2587, 2592, 2619, 2526, 2601, 2498, 2506, 2575, 2511, 2495, 2552, 2559, 2560, 2609, 2523, 2513, 2554, 2530, 2570, 2540, 2636, 2629, 2540, 2504, 2537, 2555, 2542, 2556, 2639, 2480, 2580, 2579, 2616, 2612, 2537, 2596, 2532, 2579, 2528, 2503, 2584, 2590, 2502, 2505, 2593, 2494, 2528, 2560] 2426.0 2563.05 2471.0 2659.0 [2545, 2659, 2571, 2527, 2622, 2616, 2530, 2573, 2503, 2587, 2559, 2592, 2635, 2529, 2623, 2533, 2544, 2492, 2525, 2558, 2584, 2546, 2578, 2572, 2597, 2573, 2606, 2549, 2535, 2502, 2590, 2561, 2559, 2564, 2558, 2532, 2543, 2643, 2608, 2557, 2608, 2610, 2557, 2526, 2574, 2538, 2592, 2601, 2592, 2555, 2581, 2556, 2515, 2492, 2481, 2594, 2519, 2618, 2583, 2545, 2562, 2580, 2574, 2566, 2566, 2542, 2590, 2619, 2563, 2588, 2543, 2566, 2528, 2480, 2576, 2606, 2517, 2578, 2578, 2557, 2490, 2611, 2542, 2522, 2520, 2527, 2555, 2520, 2571, 2565, 2575, 2604, 2547, 2539, 2607, 2603, 2471, 2626, 2562, 2552] Prost-AdenoCA SBS18 C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5062.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Prost-AdenoCA SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5062.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Prost-AdenoCA SBS18 T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5062.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Prost-AdenoCA SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5062.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Prost-AdenoCA SBS18 T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 5062.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] SoftTissue-Liposarc SBS18 C>A 1936.0 2001.0 1980.66 1992.5 0.5587319384233009 0.985417689335601 89.865 4381.0 Leading 1.034 1.006 1.027 1936.0 1980.66 1897.0 2072.0 [1982, 1969, 2017, 2044, 1921, 2044, 2010, 1989, 1995, 2003, 1961, 1959, 1967, 1961, 1935, 1993, 2037, 1969, 1967, 1949, 1962, 2016, 2023, 1998, 2003, 1923, 1970, 1964, 1929, 1986, 1919, 1960, 2017, 1987, 1936, 1928, 1937, 1916, 1918, 1985, 1999, 1967, 1963, 2002, 2009, 1976, 1996, 1935, 1955, 2018, 1983, 1988, 2016, 1963, 1948, 1916, 1967, 1943, 1977, 1966, 1962, 2063, 2023, 2031, 2072, 2005, 1957, 1922, 1954, 2028, 1980, 2013, 2003, 1972, 1983, 2038, 1934, 1973, 2038, 2005, 1897, 1991, 1947, 1966, 1962, 1954, 1949, 2016, 2008, 2013, 2009, 1958, 1987, 1937, 2054, 1969, 1976, 2055, 1997, 2029] 2001.0 1992.5 1913.0 2077.0 [1993, 1983, 1913, 1941, 2068, 1961, 1981, 1995, 1987, 1945, 1999, 1984, 1985, 1958, 2002, 1988, 1958, 1990, 1980, 2021, 2008, 1963, 1948, 1993, 1977, 2072, 2018, 2014, 2077, 2009, 2042, 2016, 1970, 1994, 2029, 2046, 2040, 2033, 2049, 2011, 1949, 1979, 2028, 1969, 1980, 1981, 1966, 2037, 2028, 1964, 1971, 2007, 1957, 2021, 2041, 2046, 2041, 2007, 1992, 1990, 2013, 1917, 1955, 1949, 1921, 1967, 2007, 2013, 2013, 1931, 1981, 1943, 1954, 2003, 2005, 1913, 2050, 1980, 1940, 1994, 2069, 1980, 2032, 2001, 2020, 2039, 2017, 1977, 1967, 1954, 1995, 2019, 2000, 2022, 1924, 2017, 2017, 1934, 1981, 1941] SoftTissue-Liposarc SBS18 C>G 23.0 13.0 17.63 18.94 0.2355048041628175 0.5576031409687828 0.822 4381.0 Lagging 1.769 0.931 1.901 1 1 1 1 1 23.0 17.63 9.0 27.0 [16, 21, 19, 19, 19, 16, 15, 19, 19, 20, 20, 16, 15, 19, 18, 20, 17, 20, 15, 21, 15, 20, 13, 18, 16, 17, 18, 27, 12, 19, 20, 14, 15, 14, 20, 9, 21, 21, 16, 20, 17, 17, 18, 18, 21, 14, 17, 18, 15, 19, 18, 16, 17, 19, 22, 19, 19, 18, 17, 17, 16, 13, 16, 25, 15, 13, 21, 18, 16, 17, 23, 19, 12, 12, 15, 17, 19, 20, 15, 17, 17, 23, 20, 21, 16, 17, 14, 18, 19, 19, 17, 17, 12, 19, 14, 22, 18, 20, 18, 18] 13.0 18.94 10.0 29.0 [21, 13, 19, 16, 18, 19, 21, 14, 17, 16, 16, 21, 23, 16, 14, 17, 21, 18, 23, 16, 19, 15, 24, 20, 21, 19, 22, 10, 25, 17, 16, 23, 23, 22, 16, 29, 18, 17, 20, 17, 19, 15, 19, 20, 15, 24, 20, 17, 21, 18, 19, 21, 18, 19, 16, 17, 15, 18, 19, 21, 18, 19, 21, 12, 21, 21, 15, 17, 15, 20, 16, 17, 24, 25, 24, 17, 19, 16, 21, 21, 20, 15, 15, 17, 24, 23, 22, 18, 19, 21, 19, 21, 24, 20, 21, 18, 19, 16, 20, 20] SoftTissue-Liposarc SBS18 C>T 43.0 54.0 49.2 50.07 0.4782690745492668 0.9071899896794516 2.214 4381.0 Leading 1.256 1.018 1.234 1 1 43.0 49.2 38.0 63.0 [45, 53, 47, 43, 51, 51, 54, 46, 53, 50, 63, 48, 60, 54, 43, 47, 47, 53, 45, 56, 44, 47, 49, 50, 49, 40, 55, 45, 55, 59, 38, 40, 44, 48, 51, 51, 50, 41, 48, 47, 51, 39, 57, 54, 52, 51, 55, 39, 51, 44, 47, 50, 50, 42, 43, 48, 54, 53, 48, 48, 40, 45, 57, 53, 47, 49, 50, 53, 51, 49, 53, 53, 49, 44, 43, 44, 47, 46, 44, 56, 63, 42, 39, 48, 41, 54, 48, 55, 61, 49, 61, 51, 41, 42, 54, 43, 60, 56, 51, 52] 54.0 50.07 38.0 60.0 [54, 43, 52, 57, 54, 49, 49, 50, 47, 46, 38, 52, 43, 49, 48, 50, 51, 48, 53, 45, 55, 60, 47, 53, 48, 58, 48, 50, 42, 42, 59, 57, 51, 49, 45, 50, 48, 57, 51, 53, 46, 60, 46, 44, 49, 52, 43, 58, 49, 49, 58, 51, 55, 56, 57, 49, 44, 47, 52, 53, 59, 55, 42, 45, 56, 46, 45, 49, 52, 49, 49, 51, 53, 52, 54, 56, 50, 50, 57, 44, 40, 55, 56, 55, 55, 47, 53, 43, 41, 49, 39, 53, 53, 56, 48, 57, 38, 43, 45, 48] SoftTissue-Liposarc SBS18 T>A 115.0 129.0 126.45 125.07 0.5293206010463339 0.9609400983814651 5.57 4381.0 Leading 1.122 0.989 1.134 1 115.0 126.45 103.0 150.0 [120, 121, 123, 131, 126, 121, 127, 124, 132, 136, 129, 122, 119, 130, 134, 123, 133, 128, 125, 114, 140, 112, 145, 117, 124, 126, 129, 136, 119, 132, 132, 127, 125, 122, 117, 136, 132, 120, 123, 144, 150, 124, 126, 141, 136, 119, 129, 148, 127, 126, 128, 138, 124, 121, 129, 122, 145, 122, 111, 131, 132, 135, 121, 119, 117, 116, 114, 137, 125, 139, 121, 121, 112, 122, 124, 126, 111, 112, 103, 137, 115, 122, 128, 134, 127, 127, 118, 135, 129, 112, 138, 141, 118, 131, 143, 134, 115, 121, 125, 115] 129.0 125.07 109.0 144.0 [134, 130, 135, 125, 124, 126, 122, 127, 127, 118, 122, 133, 131, 125, 123, 124, 121, 123, 124, 132, 117, 131, 110, 134, 124, 124, 116, 115, 134, 117, 130, 128, 130, 124, 140, 114, 124, 131, 119, 113, 110, 125, 125, 113, 121, 134, 126, 109, 117, 120, 120, 110, 131, 130, 118, 128, 113, 123, 141, 119, 116, 128, 129, 123, 130, 131, 132, 112, 131, 109, 129, 124, 137, 127, 125, 124, 142, 144, 137, 116, 136, 122, 131, 121, 123, 121, 138, 125, 128, 135, 118, 113, 134, 112, 119, 122, 132, 134, 126, 137] SoftTissue-Liposarc SBS18 T>C 11.0 15.0 13.81 13.55 0.7812512794294926 1.0 0.593 4381.0 Leading 1.364 0.981 1.39 1 1 1 11.0 13.81 7.0 19.0 [13, 14, 9, 14, 13, 12, 12, 14, 11, 17, 13, 18, 11, 18, 16, 12, 11, 18, 15, 15, 19, 17, 14, 15, 9, 15, 15, 14, 18, 14, 17, 15, 17, 16, 15, 15, 13, 13, 16, 13, 11, 12, 15, 16, 15, 19, 9, 17, 10, 11, 13, 9, 16, 8, 15, 12, 16, 12, 11, 9, 13, 10, 15, 16, 15, 7, 10, 17, 16, 11, 15, 17, 13, 18, 15, 11, 13, 14, 13, 16, 15, 19, 14, 12, 17, 10, 13, 10, 12, 14, 15, 15, 16, 14, 17, 14, 13, 7, 15, 12] 15.0 13.55 7.0 22.0 [13, 14, 17, 14, 16, 15, 15, 10, 17, 11, 13, 10, 16, 9, 12, 15, 14, 8, 11, 10, 10, 11, 14, 12, 18, 13, 13, 14, 10, 14, 8, 14, 11, 12, 14, 12, 16, 15, 12, 17, 14, 13, 15, 13, 12, 7, 15, 13, 14, 16, 15, 20, 10, 22, 11, 16, 13, 14, 14, 18, 15, 17, 11, 11, 11, 20, 14, 12, 12, 17, 11, 12, 15, 10, 13, 16, 14, 11, 14, 10, 14, 9, 14, 15, 12, 19, 15, 16, 14, 12, 13, 14, 12, 15, 12, 13, 16, 22, 12, 15] SoftTissue-Liposarc SBS18 T>G 18.0 23.0 20.33 19.74 0.6545388290253122 1.0 0.936 4381.0 Leading 1.278 0.971 1.316 1 1 1 18.0 20.33 13.0 29.0 [25, 29, 23, 21, 20, 15, 24, 22, 19, 22, 21, 21, 19, 26, 16, 20, 23, 19, 23, 27, 20, 25, 17, 18, 20, 21, 27, 17, 23, 18, 18, 25, 18, 19, 21, 16, 19, 23, 19, 27, 21, 20, 19, 17, 18, 16, 24, 22, 26, 22, 23, 18, 16, 24, 20, 20, 20, 19, 23, 21, 20, 18, 14, 16, 22, 16, 23, 21, 23, 20, 15, 19, 16, 21, 21, 16, 19, 18, 21, 21, 18, 20, 14, 23, 19, 23, 21, 20, 24, 24, 25, 16, 21, 23, 13, 21, 20, 17, 19, 17] 23.0 19.74 12.0 27.0 [16, 12, 18, 22, 20, 22, 19, 18, 16, 21, 19, 21, 20, 12, 23, 21, 17, 19, 17, 15, 20, 14, 25, 23, 21, 19, 14, 23, 17, 19, 17, 17, 26, 21, 20, 22, 21, 14, 24, 16, 23, 19, 19, 25, 22, 24, 13, 17, 15, 19, 18, 21, 24, 19, 21, 21, 19, 21, 16, 17, 21, 20, 21, 24, 19, 25, 19, 20, 19, 18, 27, 21, 23, 18, 21, 23, 19, 20, 22, 19, 24, 19, 25, 19, 20, 17, 18, 21, 17, 15, 13, 23, 21, 18, 26, 19, 22, 19, 21, 24] Stomach-AdenoCA SBS18 C>A 84490.0 81579.0 84014.22 84428.54 7.530052010200912e-09 4.441394455494807e-08 99.159 167477.0 Lagging 1.036 0.995 1.041 84490.0 84014.22 83629.0 84420.0 [84020, 83908, 83920, 83766, 83920, 83712, 84339, 83647, 83758, 83939, 84123, 83991, 83921, 83761, 84015, 84066, 84229, 83733, 83691, 84396, 84150, 84297, 84175, 83819, 84140, 83855, 84029, 83980, 84009, 83731, 84281, 84232, 84004, 84230, 84151, 84076, 84264, 84233, 83969, 83818, 83834, 83957, 83958, 84086, 83901, 83835, 83913, 83889, 84087, 84300, 84136, 84136, 84088, 83989, 83849, 83740, 84061, 83629, 83739, 83943, 83938, 84279, 84389, 84134, 83954, 83752, 83919, 83862, 83781, 84235, 83903, 83936, 84082, 84096, 84014, 83661, 84044, 84290, 84330, 84311, 83871, 83947, 84420, 84118, 84188, 83687, 83935, 83931, 84286, 84111, 83949, 83937, 84049, 84155, 83833, 84168, 84272, 84232, 83913, 84142] 81579.0 84428.54 83953.0 84875.0 [84530, 84525, 84633, 84497, 84474, 84875, 83979, 84716, 84605, 84307, 84181, 84481, 84562, 84696, 84396, 84230, 84453, 84519, 84839, 84141, 84294, 83953, 84129, 84749, 84258, 84575, 84192, 84224, 84551, 84681, 84420, 84217, 84571, 84284, 84293, 84534, 84259, 84092, 84630, 84488, 84461, 84502, 84613, 84281, 84415, 84488, 84552, 84574, 84421, 84173, 84379, 84636, 84382, 84650, 84602, 84737, 84391, 84813, 84666, 84459, 84403, 84282, 84052, 84373, 84374, 84773, 84622, 84544, 84686, 84310, 84555, 84396, 84352, 84392, 84450, 84627, 84272, 84119, 84277, 84083, 84556, 84605, 84066, 84284, 84250, 84801, 84487, 84520, 84262, 84194, 84467, 84553, 84380, 84250, 84457, 84366, 84217, 84049, 84582, 84338] Stomach-AdenoCA SBS18 C>G 28.0 24.0 26.14 25.73 0.8445334451595303 1.0 0.031 167477.0 Lagging 1.167 1.016 1.148 1 28.0 26.14 19.0 36.0 [30, 32, 28, 28, 33, 27, 20, 28, 25, 19, 27, 22, 22, 26, 27, 32, 20, 25, 28, 28, 22, 22, 29, 36, 27, 22, 33, 23, 29, 30, 24, 28, 28, 22, 24, 26, 26, 22, 29, 28, 28, 23, 29, 28, 22, 28, 29, 26, 23, 27, 25, 20, 25, 34, 32, 22, 26, 26, 25, 25, 27, 26, 22, 27, 27, 27, 27, 31, 24, 23, 28, 20, 32, 34, 30, 28, 21, 33, 28, 30, 20, 24, 28, 27, 27, 20, 22, 21, 25, 32, 28, 19, 25, 24, 20, 24, 22, 29, 27, 25] 24.0 25.73 15.0 34.0 [22, 21, 25, 26, 22, 24, 31, 28, 22, 34, 25, 28, 27, 25, 23, 20, 26, 26, 22, 25, 28, 31, 24, 15, 26, 31, 21, 28, 24, 23, 29, 27, 26, 33, 25, 24, 26, 26, 22, 24, 26, 28, 23, 22, 29, 25, 24, 29, 31, 27, 26, 32, 28, 18, 22, 32, 29, 27, 27, 28, 26, 27, 28, 25, 20, 23, 24, 22, 25, 29, 25, 29, 16, 16, 19, 25, 33, 21, 25, 25, 29, 27, 24, 25, 26, 32, 31, 27, 26, 19, 21, 28, 29, 29, 34, 28, 28, 24, 27, 28] Stomach-AdenoCA SBS18 C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 167477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS18 T>A 658.0 685.0 679.91 668.8 0.4640830940554508 0.8939156376207005 0.802 167477.0 Leading 1.041 0.984 1.058 658.0 679.91 625.0 734.0 [693, 680, 694, 665, 685, 690, 698, 665, 676, 700, 694, 674, 716, 689, 653, 660, 699, 689, 672, 683, 649, 664, 657, 688, 662, 670, 684, 689, 706, 672, 699, 660, 673, 676, 676, 661, 667, 691, 625, 675, 684, 676, 652, 685, 660, 689, 699, 667, 664, 694, 658, 663, 680, 680, 711, 676, 684, 685, 665, 696, 694, 680, 676, 654, 705, 664, 691, 734, 691, 685, 694, 679, 697, 678, 677, 687, 667, 672, 674, 676, 690, 677, 683, 656, 665, 701, 729, 688, 686, 723, 682, 638, 667, 706, 705, 679, 669, 683, 644, 658] 685.0 668.8 631.0 718.0 [658, 677, 641, 675, 655, 666, 634, 689, 704, 652, 658, 691, 645, 683, 698, 702, 653, 679, 672, 658, 695, 683, 696, 662, 667, 698, 665, 646, 654, 695, 655, 695, 683, 672, 660, 660, 663, 662, 713, 660, 671, 669, 687, 673, 671, 659, 653, 686, 684, 681, 683, 672, 656, 644, 635, 678, 661, 670, 680, 648, 657, 648, 688, 704, 634, 696, 676, 631, 647, 663, 673, 657, 648, 667, 655, 654, 687, 663, 682, 660, 658, 692, 662, 690, 663, 658, 636, 668, 649, 632, 644, 718, 676, 657, 632, 681, 671, 680, 708, 680] Stomach-AdenoCA SBS18 T>C 0.0 0.0 0.0 0.0 1.0 1.0 0.0 167477.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS18 T>G 5.0 8.0 6.8 6.11 0.6950975905236254 1.0 0.008 167477.0 Leading 1.6 0.899 1.781 1 1 1 1 1 5.0 6.8 2.0 11.0 [6, 9, 4, 5, 6, 8, 8, 7, 5, 8, 10, 3, 8, 8, 6, 5, 7, 6, 7, 7, 6, 6, 7, 9, 9, 2, 6, 9, 5, 9, 7, 9, 3, 5, 6, 7, 7, 9, 6, 6, 7, 8, 8, 8, 7, 9, 6, 4, 8, 8, 6, 6, 8, 9, 6, 6, 8, 8, 5, 7, 6, 5, 11, 9, 4, 7, 7, 8, 5, 7, 5, 7, 5, 4, 9, 7, 8, 8, 3, 6, 6, 7, 6, 8, 5, 8, 8, 6, 8, 7, 5, 7, 8, 11, 7, 8, 6, 6, 6, 8] 8.0 6.11 3.0 10.0 [7, 4, 10, 8, 7, 5, 6, 7, 7, 6, 4, 9, 5, 6, 6, 7, 6, 5, 5, 5, 6, 8, 7, 5, 4, 10, 7, 4, 7, 5, 5, 3, 7, 7, 6, 6, 6, 4, 5, 7, 6, 6, 4, 5, 7, 5, 5, 10, 5, 5, 7, 6, 6, 4, 6, 8, 5, 6, 8, 5, 7, 8, 3, 5, 9, 5, 6, 6, 8, 6, 8, 6, 7, 8, 3, 7, 6, 6, 9, 7, 7, 7, 6, 4, 8, 6, 6, 8, 4, 7, 5, 7, 5, 3, 6, 3, 8, 7, 6, 5] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS18 C>A Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['Breast-Cancer', 'CNS-Medullo', 'ColoRect-AdenoCA', 'ESCC', 'Eso-AdenoCA', 'Head-SCC', 'Liver-HCC', 'Lung-AdenoCA', 'Ovary-AdenoCA', 'Panc-AdenoCA', 'Prost-AdenoCA', 'SoftTissue-Liposarc', 'Stomach-AdenoCA'] 13