# Only cancer types with minimum 2000 mutations for SBS signatures with average probability at least 0.75 are considered. signature cancer_type processive_group_length number_of_processive_groups log10_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_number_of_processive_groups SBS18 CNS-Medullo 2 13 2.565 0.48 1.0 11.0 4.72 2.159 7.328274733242982e-05 0.00010259584626540175 3.989 [2, 5, 4, 2, 2, 3, 8, 2, 4, 3, 3, 3, 2, 4, 2, 8, 1, 3, 9, 3, 9, 4, 3, 6, 6, 5, 4, 11, 4, 2, 5, 3, 5, 3, 3, 2, 8, 5, 1, 5, 6, 6, 2, 8, 4, 4, 2, 4, 5, 5, 4, 4, 7, 5, 8, 3, 6, 7, 5, 5, 4, 5, 4, 5, 10, 5, 6, 4, 3, 6, 1, 6, 3, 5, 10, 4, 7, 6, 5, 5, 3, 4, 9, 5, 4, 3, 5, 6, 5, 5, 4, 5, 6, 8, 1, 3, 10, 6, 4, 5] SBS18 CNS-Medullo 3 1 0.0 0.0 inf [] SBS18 ColoRect-AdenoCA 2 1425 7.262 0.48 684.0 835.0 775.71 25.844 7.2575003411343895e-137 1.5052593300130588e-136 135.822 [798, 778, 743, 786, 749, 784, 794, 739, 801, 812, 791, 771, 776, 774, 762, 807, 773, 733, 776, 684, 739, 785, 817, 759, 726, 835, 800, 804, 795, 718, 753, 756, 766, 758, 765, 760, 784, 749, 780, 802, 810, 797, 797, 776, 773, 782, 759, 804, 771, 746, 732, 743, 794, 785, 813, 752, 756, 749, 777, 770, 758, 760, 750, 803, 793, 749, 795, 777, 788, 795, 761, 722, 811, 795, 749, 769, 765, 771, 782, 796, 749, 830, 787, 797, 759, 769, 804, 771, 777, 795, 803, 799, 746, 810, 785, 810, 772, 785, 794, 772] SBS18 ColoRect-AdenoCA 3 42 3.738 0.247 2.0 15.0 7.45 2.84 1.0553962838164871e-33 1.5154408177877764e-33 32.819 [12, 13, 11, 11, 8, 7, 7, 5, 9, 10, 6, 4, 5, 5, 10, 11, 5, 12, 5, 10, 3, 6, 4, 9, 10, 7, 10, 7, 3, 4, 3, 5, 3, 9, 6, 6, 7, 7, 6, 8, 3, 9, 9, 12, 6, 7, 5, 6, 5, 10, 8, 11, 12, 9, 7, 9, 5, 7, 5, 5, 4, 11, 11, 6, 10, 15, 7, 4, 7, 10, 6, 6, 7, 7, 9, 9, 6, 7, 4, 9, 14, 7, 2, 10, 7, 9, 9, 13, 4, 4, 10, 3, 10, 5, 6, 6, 4, 11, 6, 11] SBS18 ColoRect-AdenoCA 4 1 0.0 0.0 1.0 2.0 1.167 0.373 0.6472715069443634 0.6590400797978974 0.181 [1, 1, 1, 2, 1, 1] SBS18 Head-SCC 2 72 4.277 0.48 16.0 36.0 25.99 4.33 3.4991390769065524e-26 4.5282976289378913e-26 25.344 [26, 22, 19, 26, 30, 22, 23, 30, 28, 36, 22, 23, 35, 29, 23, 20, 31, 30, 19, 26, 24, 20, 28, 31, 29, 21, 24, 17, 30, 29, 25, 35, 25, 26, 28, 17, 31, 27, 26, 18, 35, 31, 27, 24, 35, 25, 30, 23, 27, 19, 22, 24, 28, 31, 26, 30, 16, 28, 25, 32, 30, 25, 27, 26, 26, 25, 23, 30, 25, 31, 24, 30, 25, 25, 23, 29, 27, 26, 19, 18, 31, 25, 32, 26, 21, 22, 21, 27, 25, 29, 23, 24, 23, 27, 27, 26, 22, 33, 27, 25] SBS18 Lung-AdenoCA 2 8 2.079 0.48 3.0 17.0 8.38 2.719 0.5550149018506083 0.6105163920356692 0.214 [10, 12, 4, 8, 8, 12, 9, 8, 6, 11, 5, 8, 9, 8, 6, 6, 10, 5, 6, 7, 14, 5, 8, 8, 4, 11, 8, 6, 12, 17, 7, 10, 10, 8, 5, 12, 9, 11, 12, 10, 10, 7, 8, 3, 4, 8, 10, 8, 10, 11, 10, 6, 8, 13, 10, 3, 14, 8, 11, 6, 6, 7, 5, 4, 9, 7, 5, 11, 5, 9, 10, 6, 8, 7, 8, 11, 8, 11, 5, 11, 6, 10, 5, 6, 8, 7, 10, 9, 13, 13, 9, 10, 10, 10, 7, 6, 5, 12, 11, 5] SBS18 Panc-AdenoCA 2 114 4.736 0.48 30.0 68.0 47.08 7.634 1.993784289330178e-18 3.190054862928285e-18 17.496 [30, 46, 45, 36, 47, 39, 46, 46, 47, 62, 51, 41, 40, 42, 55, 40, 35, 38, 50, 52, 42, 31, 43, 39, 41, 51, 40, 49, 37, 53, 35, 41, 44, 39, 56, 49, 47, 49, 30, 52, 48, 54, 50, 45, 51, 58, 51, 64, 40, 49, 56, 51, 48, 61, 45, 52, 43, 46, 43, 47, 55, 47, 54, 32, 41, 61, 47, 48, 56, 50, 50, 42, 68, 52, 65, 60, 50, 45, 45, 45, 47, 42, 45, 54, 54, 43, 55, 49, 48, 37, 34, 57, 46, 52, 50, 44, 41, 41, 55, 43] SBS18 Panc-AdenoCA 3 6 1.792 0.182 1.0 2.0 1.2 0.4 5.744173977061159e-23 1.0211864848108726e-22 21.991 [1, 1, 1, 1, 2] SBS18 Panc-AdenoCA 4 1 0.0 0.0 inf [] SBS18 Prost-AdenoCA 2 7 1.946 0.48 1.0 8.0 3.242 1.659 0.01249402152107928 0.013629841659359215 1.866 [3, 2, 1, 5, 1, 2, 5, 3, 2, 2, 3, 2, 3, 4, 3, 1, 3, 4, 3, 4, 7, 3, 2, 1, 3, 4, 4, 4, 5, 2, 2, 3, 6, 1, 5, 4, 7, 7, 4, 6, 2, 3, 3, 2, 1, 6, 3, 2, 1, 2, 4, 2, 2, 4, 2, 3, 2, 4, 4, 3, 7, 3, 3, 8, 1, 4, 4, 2, 4, 4, 2, 1, 1, 4, 4, 4, 2, 6, 3, 1, 5, 3, 3, 3, 5, 1, 4, 5, 4, 7, 2, 1, 1, 3, 2] SBS18 Prost-AdenoCA 5 1 0.0 0.0 inf [] SBS18 Stomach-AdenoCA 2 1848 7.522 0.48 901.0 1025.0 963.45 25.443 6.453729043323007e-260 2.0078268134782684e-259 258.697 [971, 933, 984, 956, 933, 955, 953, 967, 944, 958, 929, 928, 1011, 988, 978, 971, 964, 925, 950, 976, 975, 962, 949, 1016, 980, 970, 954, 901, 941, 997, 960, 967, 969, 967, 984, 930, 949, 973, 932, 968, 946, 990, 989, 940, 996, 935, 949, 944, 983, 965, 961, 966, 976, 991, 990, 973, 933, 985, 933, 1007, 1025, 935, 946, 928, 970, 944, 966, 926, 967, 1001, 1009, 977, 1020, 942, 965, 952, 970, 942, 934, 997, 935, 974, 980, 976, 966, 904, 965, 958, 961, 976, 959, 982, 995, 1023, 946, 934, 958, 992, 944, 931] SBS18 Stomach-AdenoCA 3 32 3.466 0.221 2.0 14.0 7.99 2.938 2.9389976495022923e-16 4.840702010944953e-16 15.315 [11, 5, 7, 9, 6, 8, 7, 12, 4, 7, 4, 9, 10, 5, 10, 10, 11, 10, 6, 12, 10, 7, 10, 5, 7, 8, 13, 12, 7, 6, 6, 5, 3, 4, 2, 14, 12, 11, 5, 13, 6, 9, 6, 6, 11, 8, 8, 13, 6, 9, 3, 10, 6, 14, 9, 4, 5, 6, 10, 9, 6, 10, 6, 6, 6, 6, 12, 8, 8, 11, 8, 12, 4, 9, 4, 4, 9, 3, 7, 8, 5, 10, 12, 6, 9, 5, 10, 11, 9, 7, 14, 3, 7, 4, 8, 9, 10, 7, 14, 11] SBS18 Stomach-AdenoCA 4 4 1.386 0.088 1.0 1.0 1.0 0.0 0.0 0.0 inf [1, 1, 1, 1, 1] SBS18 Stomach-AdenoCA 7 1 0.0 0.0 inf [] SBS18 Breast-Cancer 2 177 5.176 0.48 41.0 76.0 59.94 7.448 6.798464570647052e-55 1.1978247100663853e-54 53.922 [61, 50, 56, 66, 45, 65, 50, 58, 56, 66, 66, 44, 62, 63, 57, 73, 68, 65, 65, 50, 62, 55, 64, 71, 53, 47, 65, 53, 64, 67, 61, 55, 62, 68, 74, 58, 44, 72, 59, 55, 55, 56, 63, 70, 58, 61, 62, 60, 57, 56, 60, 58, 53, 56, 72, 57, 59, 57, 41, 66, 72, 66, 49, 54, 64, 62, 68, 68, 57, 54, 58, 55, 57, 55, 56, 64, 67, 49, 65, 70, 63, 47, 45, 76, 64, 61, 59, 65, 57, 74, 64, 54, 64, 59, 59, 66, 54, 47, 67, 67] SBS18 Breast-Cancer 3 3 1.099 0.102 1.0 1.0 1.0 0.0 0.0 0.0 inf [1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1] SBS18 Breast-Cancer 5 1 0.0 0.0 inf [] SBS18 Eso-AdenoCA 2 1250 7.131 0.48 551.0 703.0 640.33 27.456 2.0369666526960243e-107 2.685092405826577e-107 106.571 [668, 652, 636, 634, 644, 628, 614, 615, 586, 604, 635, 611, 632, 665, 612, 631, 703, 657, 651, 627, 596, 632, 623, 634, 686, 611, 637, 635, 649, 622, 665, 626, 615, 608, 645, 660, 666, 594, 652, 577, 674, 679, 652, 624, 630, 686, 598, 658, 622, 618, 679, 671, 637, 658, 628, 608, 659, 684, 654, 665, 646, 644, 679, 681, 669, 625, 654, 650, 674, 600, 625, 653, 617, 656, 588, 632, 618, 635, 640, 697, 652, 667, 647, 649, 675, 608, 628, 643, 650, 628, 684, 648, 663, 627, 673, 644, 638, 551, 635, 618] SBS18 Eso-AdenoCA 3 43 3.761 0.253 1.0 11.0 5.556 2.417 2.2272191861460603e-53 2.5835742559294307e-53 52.588 [5, 6, 7, 9, 8, 2, 9, 3, 2, 1, 3, 6, 5, 1, 5, 8, 5, 3, 7, 3, 7, 8, 3, 9, 8, 7, 5, 11, 3, 4, 6, 5, 8, 5, 6, 2, 7, 6, 10, 2, 2, 7, 8, 10, 8, 6, 2, 4, 4, 7, 11, 5, 4, 6, 8, 8, 4, 10, 3, 6, 5, 4, 7, 10, 2, 4, 8, 7, 3, 5, 10, 8, 7, 5, 6, 2, 7, 5, 4, 3, 8, 6, 3, 4, 4, 5, 8, 7, 7, 2, 3, 7, 2, 5, 6, 5, 5, 3, 5] SBS18 Eso-AdenoCA 4 5 1.609 0.108 1.0 1.0 1.0 0.0 0.0 0.0 inf [1, 1, 1, 1, 1, 1, 1, 1, 1, 1] SBS18 Eso-AdenoCA 5 1 0.0 0.0 inf [] SBS18 ESCC 2 2129 7.663 0.48 1031.0 1186.0 1119.73 30.818 6.432072391727251e-231 2.2264865971363563e-230 229.652 [1159, 1100, 1118, 1152, 1130, 1066, 1095, 1107, 1173, 1171, 1172, 1114, 1031, 1082, 1141, 1178, 1143, 1113, 1112, 1117, 1094, 1092, 1120, 1180, 1097, 1100, 1088, 1116, 1152, 1102, 1120, 1095, 1111, 1123, 1125, 1158, 1095, 1098, 1095, 1097, 1111, 1139, 1093, 1079, 1102, 1065, 1139, 1071, 1126, 1095, 1082, 1083, 1140, 1112, 1082, 1121, 1132, 1155, 1075, 1114, 1174, 1150, 1080, 1138, 1091, 1186, 1117, 1107, 1110, 1161, 1135, 1134, 1108, 1149, 1169, 1089, 1102, 1091, 1129, 1160, 1173, 1090, 1124, 1118, 1149, 1123, 1143, 1167, 1127, 1133, 1144, 1105, 1056, 1096, 1125, 1122, 1148, 1121, 1125, 1156] SBS18 ESCC 3 27 3.296 0.206 2.0 12.0 5.76 2.25 4.544398864369304e-21 8.891215169418204e-21 20.051 [4, 3, 3, 9, 7, 6, 5, 2, 3, 4, 8, 5, 5, 6, 2, 3, 8, 10, 6, 4, 3, 5, 4, 5, 3, 7, 4, 5, 7, 5, 4, 4, 5, 8, 4, 8, 5, 5, 8, 5, 4, 3, 6, 6, 9, 3, 8, 6, 8, 5, 5, 8, 3, 6, 10, 9, 5, 4, 4, 4, 8, 10, 4, 10, 7, 5, 4, 3, 4, 8, 11, 3, 4, 5, 5, 8, 3, 7, 9, 11, 5, 5, 5, 4, 7, 5, 10, 5, 4, 12, 4, 8, 7, 5, 7, 6, 3, 7, 8, 7] SBS18 ESCC 4 4 1.386 0.087 1.0 1.0 1.0 0.0 4.544398864369304e-21 8.891215169418204e-21 20.051 [1, 1, 1] SBS18 Liver-HCC 2 10 2.303 0.48 1.0 11.0 4.737 2.218 0.009424385336878654 0.012702432410575577 1.896 [3, 3, 3, 6, 4, 6, 3, 3, 3, 7, 5, 1, 6, 7, 6, 2, 9, 5, 8, 3, 7, 5, 7, 2, 2, 5, 8, 3, 4, 3, 11, 4, 3, 3, 7, 3, 5, 4, 3, 4, 5, 4, 6, 3, 3, 5, 6, 6, 8, 2, 3, 8, 4, 6, 6, 2, 3, 3, 8, 2, 4, 7, 4, 1, 10, 5, 1, 4, 6, 7, 8, 3, 7, 4, 6, 3, 3, 6, 3, 3, 10, 2, 4, 3, 5, 3, 5, 3, 9, 6, 2, 5, 6, 3, 2, 5, 6, 10, 6] SBS18 Ovary-AdenoCA 2 20 2.996 0.48 3.0 19.0 11.53 3.5 0.008287368410890977 0.010497333320461905 1.979 [14, 19, 18, 17, 14, 12, 11, 12, 12, 9, 17, 8, 5, 8, 14, 10, 9, 12, 11, 4, 17, 18, 11, 11, 12, 5, 11, 11, 8, 9, 15, 11, 10, 18, 8, 7, 12, 12, 8, 15, 11, 10, 12, 14, 11, 12, 12, 8, 14, 14, 10, 15, 11, 10, 12, 10, 11, 9, 15, 11, 17, 14, 12, 13, 12, 16, 13, 3, 15, 14, 13, 18, 10, 12, 14, 6, 8, 9, 8, 16, 11, 9, 7, 12, 8, 15, 19, 10, 9, 4, 15, 17, 8, 9, 13, 14, 6, 7, 11, 9] SBS18 Ovary-AdenoCA 3 2 0.693 0.111 1.0 1.0 1.0 0.0 0.0 0.0 inf [1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1] SBS18 SoftTissue-Liposarc 2 37 3.611 0.48 9.0 27.0 18.5 3.67 3.0110201187459874e-07 3.613224142495185e-07 6.442 [18, 18, 16, 19, 14, 22, 18, 15, 22, 17, 16, 27, 18, 24, 23, 18, 16, 18, 23, 19, 16, 17, 20, 21, 20, 17, 16, 15, 18, 21, 23, 16, 9, 15, 20, 19, 19, 13, 26, 22, 19, 20, 14, 17, 11, 16, 19, 12, 12, 21, 12, 20, 25, 21, 14, 15, 23, 15, 18, 19, 19, 17, 21, 21, 22, 17, 25, 16, 15, 18, 15, 15, 14, 15, 20, 22, 18, 15, 24, 17, 23, 13, 16, 18, 22, 19, 22, 19, 22, 27, 13, 23, 16, 22, 19, 18, 20, 23, 17, 25] signature cancer_type processive_group_length avg_number_of_processive_groups log10_avg_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_avg_number_of_processive_groups SBS18 ACROSS_ALL_CANCER_TYPES 2 546.923 2.738 0.48 274.769 295.077 283.334 4.244 0.0 0.0 inf [289.462, 280.0, 280.538, 285.615, 278.538, 278.154, 279.154, 277.308, 283.385, 289.077, 285.769, 275.462, 279.231, 284.462, 283.231, 289.615, 289.615, 277.538, 283.308, 274.769, 277.077, 279.154, 284.231, 290.692, 281.462, 283.231, 281.462, 278.846, 286.077, 280.154, 283.231, 278.615, 279.615, 279.769, 286.538, 283.0, 282.769, 278.0, 279.077, 279.308, 287.077, 292.0, 285.846, 277.308, 283.0, 281.769, 280.0, 281.846, 282.769, 277.154, 279.615, 280.846, 287.154, 288.692, 285.231, 279.154, 281.308, 288.462, 277.615, 288.231, 293.615, 283.077, 279.538, 285.692, 286.0, 285.077, 286.462, 280.462, 286.538, 288.462, 285.462, 281.692, 288.385, 286.231, 282.846, 280.385, 280.385, 277.846, 281.692, 295.077, 285.231, 285.846, 284.923, 287.923, 287.692, 275.231, 287.692, 287.077, 285.154, 287.231, 288.923, 286.923, 280.0, 288.385, 285.308, 284.249, 283.326, 279.326, 284.557, 281.845] SBS18 ACROSS_ALL_CANCER_TYPES 3 19.5 1.29 0.226 2.275 5.125 3.744 0.638 1.839956148224105e-132 1.839956148224105e-132 131.735 [4.375, 3.75, 3.875, 5.125, 4.125, 3.275, 3.9, 3.15, 2.65, 3.15, 3.025, 3.4, 3.525, 2.525, 3.775, 4.4, 4.025, 4.775, 3.4, 4.025, 3.275, 3.65, 3.025, 3.9, 3.9, 4.025, 4.4, 4.775, 2.9, 2.775, 2.775, 2.775, 2.775, 3.65, 2.65, 4.15, 4.275, 4.025, 4.025, 3.9, 2.275, 3.9, 4.025, 4.65, 4.65, 3.4, 3.275, 4.025, 3.275, 4.275, 3.775, 4.65, 3.525, 4.775, 4.65, 4.15, 2.775, 3.775, 3.15, 3.4, 3.275, 4.775, 3.9, 4.4, 3.525, 4.15, 4.275, 3.15, 3.15, 4.65, 4.775, 4.025, 3.15, 3.65, 3.4, 3.275, 3.525, 3.15, 3.4, 4.275, 4.4, 3.9, 3.15, 3.4, 3.775, 3.4, 5.025, 4.9, 3.4, 3.525, 4.275, 3.025, 3.65, 2.775, 3.775, 3.65, 3.15, 3.9, 4.525, 4.719] SBS18 ACROSS_ALL_CANCER_TYPES 4 3.0 0.477 0.084 0.8 1.0 0.833 0.018 0.0 0.0 inf [0.8, 0.8, 0.8, 1.0, 0.8, 0.8, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833, 0.833] SBS18 ACROSS_ALL_CANCER_TYPES 5 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 inf [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0] SBS18 ACROSS_ALL_CANCER_TYPES 7 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 inf [0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0, 0.0]