# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. signature cancer_type real_number_of_mutations_array real_normalized_mutations_density_array simulations_means_normalized_mutations_density_array cancer_type_slope replication_timing_diff_btw_max_and_min abs_replication_timing_diff_btw_medians cancer_type_decision cutoff number_of_mutations average_probability num_of_tissues_with_increasing_decision num_of_tissues_with_flat_decision num_of_tissues_with_decreasing_decision num_of_all_tissues SBS17b Bone-Osteosarc [30, 45, 103, 182, 234, 314, 421, 539, 595, 255] [0.046, 0.068, 0.156, 0.277, 0.356, 0.478, 0.642, 0.824, 0.911, 1.0] [0.645, 0.763, 0.808, 0.848, 0.865, 0.885, 0.905, 0.914, 0.947, 0.946] 0.115 0.954 0.843 INC 0.5 2725 0.813 SBS17b ColoRect-AdenoCA [97, 198, 336, 509, 990, 1427, 1961, 2451, 3173, 1425] [0.026, 0.054, 0.091, 0.138, 0.269, 0.389, 0.535, 0.67, 0.87, 1.0] [0.591, 0.743, 0.817, 0.866, 0.911, 0.917, 0.934, 0.966, 0.984, 0.967] 0.113 0.974 0.816 INC 0.5 12593 0.817 SBS17b Lung-AdenoCA [302, 451, 621, 829, 937, 1174, 1575, 2110, 2586, 1082] [0.11, 0.164, 0.226, 0.302, 0.343, 0.429, 0.576, 0.777, 0.953, 1.0] [0.722, 0.801, 0.831, 0.862, 0.869, 0.891, 0.906, 0.925, 0.941, 0.996] 0.104 0.89 0.789 INC 0.5 11733 0.77 SBS17b Panc-AdenoCA [744, 971, 1283, 1821, 2832, 3817, 4848, 6154, 7388, 3165] [0.091, 0.119, 0.157, 0.223, 0.347, 0.469, 0.595, 0.758, 0.912, 1.0] [0.663, 0.807, 0.867, 0.905, 0.924, 0.943, 0.962, 0.984, 0.983, 0.985] 0.109 0.909 0.793 INC 0.5 33068 0.817 SBS17b Stomach-AdenoCA [8496, 12329, 17378, 23905, 35687, 50538, 62731, 76329, 96461, 42623] [0.077, 0.112, 0.158, 0.217, 0.324, 0.461, 0.572, 0.698, 0.884, 1.0] [0.657, 0.81, 0.869, 0.901, 0.928, 0.948, 0.966, 0.98, 0.992, 0.999] 0.107 0.923 0.772 INC 0.5 426806 0.876 SBS17b Biliary-AdenoCA [129, 128, 186, 213, 308, 390, 413, 432, 505, 182] [0.253, 0.251, 0.365, 0.419, 0.605, 0.768, 0.814, 0.854, 1.0, 0.923] [0.752, 0.844, 0.879, 0.894, 0.91, 0.924, 0.923, 0.912, 0.913, 0.937] 0.091 0.749 0.67 INC 0.54 2887 0.756 SBS17b Breast-Cancer [296, 542, 987, 1458, 2195, 2958, 3768, 4583, 5447, 2186] [0.052, 0.096, 0.175, 0.259, 0.389, 0.526, 0.67, 0.817, 0.973, 1.0] [0.655, 0.789, 0.829, 0.872, 0.894, 0.916, 0.926, 0.938, 0.985, 0.989] 0.117 0.948 0.877 INC 0.5 24420 0.868 SBS17b Eso-AdenoCA [8694, 16456, 29050, 46352, 77650, 115066, 144088, 179584, 223061, 95759] [0.035, 0.067, 0.117, 0.188, 0.314, 0.467, 0.585, 0.731, 0.91, 1.0] [0.67, 0.821, 0.876, 0.906, 0.93, 0.952, 0.972, 0.987, 0.991, 1.0] 0.115 0.965 0.843 INC 0.5 937126 0.901 SBS17b ESCC [404, 667, 1049, 1706, 2778, 4093, 5326, 6589, 8290, 3791] [0.041, 0.068, 0.107, 0.174, 0.284, 0.42, 0.546, 0.677, 0.854, 1.0] [0.614, 0.783, 0.85, 0.883, 0.913, 0.933, 0.955, 0.965, 0.971, 0.997] 0.11 0.959 0.786 INC 0.5 34741 0.821 SBS17b Kidney-ChRCC [37, 62, 139, 177, 232, 309, 409, 417, 402, 180] [0.08, 0.133, 0.299, 0.381, 0.499, 0.667, 0.883, 0.903, 0.872, 1.0] [0.643, 0.811, 0.876, 0.884, 0.882, 0.903, 0.929, 0.924, 0.909, 0.919] 0.11 0.92 0.77 INC 0.5 2364 0.803 SBS17b Liver-HCC [423, 353, 318, 325, 296, 257, 265, 310, 273, 99] [1.0, 0.835, 0.752, 0.769, 0.702, 0.611, 0.631, 0.741, 0.65, 0.592] [0.833, 0.871, 0.902, 0.912, 0.923, 0.936, 0.931, 0.936, 0.911, 0.862] -0.033 0.408 0.184 DEC 0.67 2922 0.766 SBS17b Lymph-BNHL [1300, 2302, 3629, 5391, 7810, 9967, 12795, 14575, 15566, 5698] [0.083, 0.146, 0.231, 0.343, 0.497, 0.637, 0.818, 0.935, 1.0, 0.922] [0.704, 0.801, 0.853, 0.884, 0.909, 0.915, 0.942, 0.955, 0.977, 0.999] 0.113 0.917 0.788 INC 0.5 79057 0.776 SBS17b Panc-Endocrine [27, 50, 56, 92, 163, 304, 430, 526, 745, 404] [0.026, 0.048, 0.054, 0.088, 0.156, 0.292, 0.414, 0.507, 0.72, 1.0] [0.554, 0.724, 0.78, 0.821, 0.857, 0.877, 0.892, 0.899, 0.937, 0.965] 0.102 0.974 0.672 INC 0.5 2798 0.792 SBS17b Skin-Melanoma [47, 88, 180, 352, 467, 716, 922, 1218, 1328, 434] [0.035, 0.066, 0.135, 0.263, 0.35, 0.537, 0.693, 0.918, 1.0, 0.843] [0.679, 0.767, 0.812, 0.835, 0.855, 0.859, 0.873, 0.906, 0.931, 0.991] 0.116 0.965 0.852 INC 0.5 5789 0.847 SBS17b ACROSS_ALL_CANCER_TYPES [0.147, 0.168, 0.228, 0.304, 0.409, 0.538, 0.676, 0.814, 0.942, 1.0] [0.67, 0.796, 0.846, 0.877, 0.898, 0.914, 0.93, 0.942, 0.955, 0.968] 13 0 1 14