# Only cancer types with minimum 2000 mutations for SBS signatures and minimum 1000 mutations for DBS and ID signatures with average probability at least 0.75 are considered. # For real mutations on lagging:A and leading:E strands averaged across cancer types. MutationType Across_All_Cancer_Types A:A[C>A]A 130.1 E:A[C>A]A 139.677 A:A[C>G]A 38.044 E:A[C>G]A 38.74 A:A[C>T]A 49.724 E:A[C>T]A 50.427 A:A[T>A]A 68.814 E:A[T>A]A 72.067 A:A[T>C]A 3.585 E:A[T>C]A 3.657 A:A[T>G]A 60.078 E:A[T>G]A 63.566 A:A[C>A]C 51.559 E:A[C>A]C 55.366 A:A[C>G]C 21.249 E:A[C>G]C 22.252 A:A[C>T]C 67.247 E:A[C>T]C 66.923 A:A[T>A]C 63.118 E:A[T>A]C 67.139 A:A[T>C]C 536.613 E:A[T>C]C 542.143 A:A[T>G]C 39.732 E:A[T>G]C 39.598 A:A[C>A]G 2.337 E:A[C>A]G 2.46 A:A[C>G]G 7.122 E:A[C>G]G 7.231 A:A[C>T]G 2.206 E:A[C>T]G 2.209 A:A[T>A]G 9.159 E:A[T>A]G 9.319 A:A[T>C]G 10.924 E:A[T>C]G 10.592 A:A[T>G]G 28.376 E:A[T>G]G 28.158 A:A[C>A]T 4.693 E:A[C>A]T 4.859 A:A[C>G]T 0.872 E:A[C>G]T 0.841 A:A[C>T]T 31.995 E:A[C>T]T 31.935 A:A[T>A]T 203.936 E:A[T>A]T 207.697 A:A[T>C]T 292.029 E:A[T>C]T 286.645 A:A[T>G]T 834.879 E:A[T>G]T 785.806 A:C[C>A]A 21.303 E:C[C>A]A 21.912 A:C[C>G]A 19.315 E:C[C>G]A 20.214 A:C[C>T]A 44.212 E:C[C>T]A 43.872 A:C[T>A]A 52.055 E:C[T>A]A 54.96 A:C[T>C]A 734.57 E:C[T>C]A 741.213 A:C[T>G]A 23.529 E:C[T>G]A 23.817 A:C[C>A]C 62.7 E:C[C>A]C 63.559 A:C[C>G]C 5.479 E:C[C>G]C 5.546 A:C[C>T]C 79.876 E:C[C>T]C 79.389 A:C[T>A]C 2183.909 E:C[T>A]C 2204.206 A:C[T>C]C 8008.727 E:C[T>C]C 7925.592 A:C[T>G]C 53.308 E:C[T>G]C 52.277 A:C[C>A]G 0.0 E:C[C>A]G 0.0 A:C[C>G]G 6.376 E:C[C>G]G 6.235 A:C[C>T]G 95.341 E:C[C>T]G 94.487 A:C[T>A]G 808.706 E:C[T>A]G 799.491 A:C[T>C]G 4237.801 E:C[T>C]G 4046.168 A:C[T>G]G 0.112 E:C[T>G]G 0.107 A:C[C>A]T 12.92 E:C[C>A]T 12.326 A:C[C>G]T 1.358 E:C[C>G]T 1.317 A:C[C>T]T 84.739 E:C[C>T]T 80.31 A:C[T>A]T 6376.411 E:C[T>A]T 6092.249 A:C[T>C]T 25806.297 E:C[T>C]T 24513.908 A:C[T>G]T 313.695 E:C[T>G]T 295.405 A:G[C>A]A 145.883 E:G[C>A]A 150.996 A:G[C>G]A 30.668 E:G[C>G]A 31.498 A:G[C>T]A 73.407 E:G[C>T]A 73.705 A:G[T>A]A 3.638 E:G[T>A]A 3.754 A:G[T>C]A 8.051 E:G[T>C]A 7.907 A:G[T>G]A 28.048 E:G[T>G]A 28.68 A:G[C>A]C 65.841 E:G[C>A]C 68.997 A:G[C>G]C 33.275 E:G[C>G]C 34.023 A:G[C>T]C 0.0 E:G[C>T]C 0.0 A:G[T>A]C 271.434 E:G[T>A]C 268.708 A:G[T>C]C 1110.324 E:G[T>C]C 1084.923 A:G[T>G]C 13.188 E:G[T>G]C 12.65 A:G[C>A]G 4.579 E:G[C>A]G 4.442 A:G[C>G]G 0.619 E:G[C>G]G 0.67 A:G[C>T]G 100.112 E:G[C>T]G 100.408 A:G[T>A]G 42.634 E:G[T>A]G 39.654 A:G[T>C]G 244.448 E:G[T>C]G 225.261 A:G[T>G]G 48.481 E:G[T>G]G 46.242 A:G[C>A]T 4.116 E:G[C>A]T 3.922 A:G[C>G]T 31.186 E:G[C>G]T 28.687 A:G[C>T]T 3.433 E:G[C>T]T 3.261 A:G[T>A]T 568.481 E:G[T>A]T 545.762 A:G[T>C]T 559.986 E:G[T>C]T 521.951 A:G[T>G]T 490.881 E:G[T>G]T 451.165 A:T[C>A]A 18.789 E:T[C>A]A 18.695 A:T[C>G]A 300.994 E:T[C>G]A 280.359 A:T[C>T]A 49.072 E:T[C>T]A 46.0 A:T[T>A]A 13.073 E:T[T>A]A 12.908 A:T[T>C]A 146.221 E:T[T>C]A 146.282 A:T[T>G]A 0.0 E:T[T>G]A 0.0 A:T[C>A]C 1.68 E:T[C>A]C 1.63 A:T[C>G]C 32.291 E:T[C>G]C 31.387 A:T[C>T]C 5.618 E:T[C>T]C 5.256 A:T[T>A]C 376.095 E:T[T>A]C 372.033 A:T[T>C]C 1284.917 E:T[T>C]C 1231.472 A:T[T>G]C 5.365 E:T[T>G]C 5.227 A:T[C>A]G 0.0 E:T[C>A]G 0.0 A:T[C>G]G 16.687 E:T[C>G]G 15.251 A:T[C>T]G 10.238 E:T[C>T]G 10.049 A:T[T>A]G 103.752 E:T[T>A]G 100.689 A:T[T>C]G 165.28 E:T[T>C]G 159.047 A:T[T>G]G 47.841 E:T[T>G]G 47.183 A:T[C>A]T 29.343 E:T[C>A]T 27.956 A:T[C>G]T 24.381 E:T[C>G]T 22.127 A:T[C>T]T 31.506 E:T[C>T]T 28.85 A:T[T>A]T 248.833 E:T[T>A]T 237.308 A:T[T>C]T 1835.246 E:T[T>C]T 1743.302 A:T[T>G]T 324.284 E:T[T>G]T 307.382 # There must be at least 1000 mutations on the strands. # Signature and mutation type must have at least 5% of all signature mutations on the strands. # Odds ratio between fold change of real mutations and fold change of simulated mutations must be at least 1.1. cancer_type signature mutation_type Lagging_real_count Leading_real_count Lagging_mean_sims_count Leading_mean_sims_count lagging_versus_leading_p_value lagging_versus_leading_q_value percentage_of_mutations_on_strands signature_number_of_mutations_on_strands significant_strand FC_REAL FC_SIMS FC fold_change_1.1 fold_change_1.2 fold_change_1.3 fold_change_1.5 fold_change_1.75 fold_change_2+ Lagging_real_count.1 Lagging_mean_sims_count.1 Lagging_min_sims_count Lagging_max_sims_count Lagging_sims_count_list Leading_real_count.1 Leading_mean_sims_count.1 Leading_min_sims_count Leading_max_sims_count Leading_sims_count_list ESCC SBS17a C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6284.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS17a C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6284.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS17a C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6284.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] ESCC SBS17a T>A 133.0 162.0 154.05 148.86 0.16385733914101902 0.425156257842388 4.694 6284.0 Leading 1.218 0.966 1.261 1 1 133.0 154.05 129.0 179.0 [175, 153, 169, 151, 150, 151, 136, 156, 163, 171, 134, 162, 137, 154, 160, 164, 149, 160, 156, 164, 152, 136, 151, 159, 146, 167, 150, 143, 142, 145, 145, 147, 154, 166, 132, 139, 163, 149, 146, 159, 156, 153, 146, 169, 157, 179, 157, 165, 154, 159, 158, 142, 153, 148, 144, 165, 146, 152, 152, 177, 168, 163, 153, 157, 159, 177, 159, 156, 146, 154, 134, 152, 147, 145, 148, 165, 129, 151, 162, 163, 156, 138, 142, 168, 166, 146, 162, 153, 153, 162, 149, 153, 142, 165, 151, 140, 158, 152, 161, 162] 162.0 148.86 124.0 172.0 [131, 148, 138, 154, 156, 148, 161, 149, 142, 134, 166, 137, 162, 142, 142, 139, 157, 137, 150, 142, 146, 149, 156, 146, 160, 141, 156, 170, 166, 158, 163, 155, 150, 135, 169, 169, 143, 152, 153, 147, 145, 146, 161, 144, 153, 129, 136, 143, 153, 145, 147, 159, 143, 149, 153, 141, 161, 155, 152, 125, 140, 150, 146, 140, 139, 124, 145, 146, 155, 149, 172, 141, 161, 163, 146, 139, 168, 152, 140, 143, 150, 162, 155, 134, 131, 155, 132, 147, 149, 146, 158, 146, 161, 145, 150, 159, 142, 148, 156, 142] ESCC SBS17a T>C 3119.0 2870.0 3111.49 3019.0 0.14593908719690474 0.3884261951041499 95.306 6284.0 Lagging 1.087 1.031 1.054 3119.0 3111.49 3031.0 3223.0 [3144, 3089, 3097, 3152, 3076, 3081, 3084, 3129, 3105, 3064, 3094, 3133, 3140, 3090, 3055, 3191, 3118, 3076, 3104, 3031, 3135, 3094, 3118, 3152, 3112, 3117, 3110, 3142, 3109, 3138, 3053, 3066, 3108, 3149, 3173, 3049, 3156, 3141, 3145, 3078, 3087, 3118, 3129, 3074, 3174, 3100, 3177, 3112, 3179, 3152, 3169, 3084, 3119, 3064, 3052, 3166, 3091, 3147, 3098, 3065, 3160, 3125, 3097, 3104, 3145, 3113, 3115, 3064, 3054, 3107, 3115, 3176, 3073, 3166, 3076, 3148, 3110, 3059, 3223, 3093, 3090, 3119, 3091, 3085, 3118, 3109, 3062, 3153, 3104, 3144, 3094, 3114, 3093, 3102, 3135, 3074, 3113, 3054, 3117, 3100] 2870.0 3019.0 2932.0 3098.0 [2999, 3030, 3002, 2977, 3041, 3059, 3012, 2959, 3045, 3051, 3057, 2999, 3003, 3023, 3071, 2965, 3015, 3045, 3018, 3059, 2969, 3009, 3023, 3035, 3020, 3006, 3036, 2983, 3035, 3001, 3098, 3059, 3026, 2977, 2958, 3097, 3015, 2983, 2962, 3069, 3054, 3020, 3009, 3046, 2982, 3025, 2947, 3035, 2932, 3009, 2990, 3010, 3002, 3042, 3094, 2974, 3016, 3020, 3019, 3058, 2969, 3009, 3029, 2988, 2987, 3031, 3047, 3078, 3087, 3009, 3041, 2973, 3032, 2985, 3064, 2959, 2990, 3012, 2933, 3032, 3015, 3006, 3019, 3020, 2985, 3037, 3081, 2979, 3010, 3024, 3053, 2995, 3077, 3012, 2999, 3069, 3030, 3067, 3037, 3055] ESCC SBS17a T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6284.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eso-AdenoCA SBS17a C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 368001.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eso-AdenoCA SBS17a C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 368001.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eso-AdenoCA SBS17a C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 368001.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Eso-AdenoCA SBS17a T>A 37774.0 34758.0 37503.74 36487.37 9.729343579830667e-08 5.448528830310525e-07 19.71 368001.0 Lagging 1.087 1.028 1.057 37774.0 37503.74 37168.0 37893.0 [37506, 37257, 37546, 37236, 37542, 37585, 37531, 37503, 37402, 37486, 37531, 37670, 37424, 37567, 37523, 37465, 37545, 37389, 37479, 37513, 37455, 37743, 37748, 37500, 37606, 37388, 37553, 37470, 37346, 37329, 37334, 37685, 37554, 37657, 37464, 37543, 37528, 37433, 37556, 37184, 37479, 37304, 37455, 37605, 37419, 37750, 37490, 37514, 37553, 37359, 37593, 37589, 37427, 37608, 37603, 37445, 37258, 37253, 37477, 37600, 37563, 37637, 37425, 37420, 37595, 37650, 37273, 37782, 37168, 37225, 37423, 37434, 37583, 37613, 37430, 37859, 37657, 37640, 37390, 37374, 37420, 37411, 37491, 37802, 37396, 37427, 37818, 37573, 37893, 37407, 37691, 37616, 37475, 37324, 37459, 37481, 37776, 37342, 37530, 37344] 34758.0 36487.37 36103.0 36808.0 [36427, 36700, 36493, 36764, 36466, 36368, 36652, 36544, 36553, 36538, 36490, 36393, 36555, 36305, 36571, 36371, 36531, 36597, 36538, 36481, 36544, 36211, 36281, 36403, 36441, 36515, 36486, 36470, 36727, 36556, 36607, 36421, 36547, 36419, 36349, 36429, 36591, 36441, 36555, 36778, 36501, 36550, 36556, 36399, 36703, 36368, 36491, 36397, 36416, 36536, 36494, 36421, 36571, 36382, 36232, 36500, 36457, 36684, 36600, 36451, 36431, 36473, 36485, 36505, 36378, 36503, 36749, 36264, 36709, 36808, 36414, 36435, 36499, 36507, 36664, 36175, 36258, 36338, 36638, 36558, 36581, 36435, 36580, 36287, 36679, 36525, 36103, 36381, 36107, 36541, 36331, 36433, 36455, 36614, 36498, 36551, 36297, 36604, 36546, 36581] Eso-AdenoCA SBS17a T>C 154553.0 140916.0 152911.31 148920.89 4.118843952121067e-37 4.514748351398659e-36 80.29 368001.0 Lagging 1.097 1.027 1.068 154553.0 152911.31 152132.0 153537.0 [152831, 153100, 153530, 153286, 152811, 153322, 153181, 152919, 152994, 152773, 152984, 152914, 152949, 153066, 152678, 152818, 152686, 153282, 152645, 153204, 153079, 152942, 152464, 153242, 152385, 152954, 152477, 153146, 152959, 153232, 153212, 153293, 152801, 153190, 153012, 152921, 152350, 153173, 152923, 153144, 152743, 152302, 153030, 152535, 152772, 152797, 152910, 152599, 152872, 152621, 153282, 152688, 152726, 152922, 152593, 152908, 152959, 152965, 152963, 152926, 153153, 153286, 152970, 153537, 152724, 153133, 153395, 153343, 152132, 152679, 152866, 153388, 152350, 152669, 152428, 153189, 153009, 152412, 152643, 153065, 152896, 153181, 153163, 152735, 152596, 153327, 152932, 152699, 152823, 153005, 152706, 152840, 152700, 152636, 152906, 152632, 153104, 152748, 152938, 153208] 140916.0 148920.89 148229.0 149797.0 [148946, 149021, 148229, 148608, 149050, 148646, 148759, 148891, 148762, 149246, 148733, 148791, 148808, 148829, 148843, 149098, 148956, 148763, 149473, 148499, 148659, 148908, 149166, 148296, 149107, 148706, 149226, 148743, 149001, 148665, 148777, 148640, 149280, 148609, 148863, 148962, 149437, 148583, 148961, 148734, 148819, 149759, 148972, 149145, 149089, 149021, 149033, 149453, 148905, 149184, 148674, 149280, 148878, 148837, 149143, 148961, 148757, 148915, 148827, 148867, 148556, 148373, 148991, 148395, 148907, 148741, 148435, 148653, 149797, 149172, 148982, 148563, 149567, 149213, 149411, 148570, 148813, 149449, 148853, 148764, 148762, 148591, 148746, 149078, 149184, 148323, 149044, 149264, 148963, 149052, 148913, 149312, 149472, 148988, 148658, 149100, 149063, 149098, 148957, 148523] Eso-AdenoCA SBS17a T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 368001.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS17a C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2312.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS17a C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2312.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS17a C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2312.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS17a T>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2312.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Lung-AdenoCA SBS17a T>C 1246.0 1066.0 1187.06 1158.56 0.02579599128018245 0.08624866788678755 100.0 2312.0 Lagging 1.169 1.025 1.141 1 1246.0 1187.06 1135.0 1238.0 [1199, 1173, 1238, 1168, 1206, 1154, 1185, 1202, 1192, 1205, 1171, 1182, 1168, 1180, 1188, 1215, 1186, 1154, 1202, 1184, 1172, 1209, 1192, 1184, 1170, 1175, 1227, 1190, 1148, 1205, 1173, 1183, 1217, 1201, 1178, 1219, 1161, 1190, 1195, 1236, 1172, 1158, 1177, 1153, 1211, 1139, 1211, 1191, 1199, 1230, 1208, 1173, 1197, 1162, 1198, 1210, 1177, 1187, 1188, 1183, 1177, 1175, 1135, 1183, 1188, 1178, 1204, 1195, 1143, 1223, 1151, 1184, 1203, 1209, 1203, 1225, 1234, 1172, 1165, 1178, 1171, 1206, 1180, 1146, 1189, 1174, 1179, 1205, 1203, 1190, 1173, 1143, 1167, 1195, 1200, 1225, 1167, 1197, 1177, 1193] 1066.0 1158.56 1104.0 1220.0 [1136, 1168, 1106, 1177, 1132, 1190, 1159, 1153, 1147, 1120, 1175, 1174, 1175, 1186, 1153, 1129, 1154, 1179, 1141, 1145, 1175, 1138, 1159, 1177, 1200, 1174, 1129, 1131, 1179, 1151, 1172, 1165, 1119, 1149, 1166, 1111, 1151, 1154, 1139, 1110, 1180, 1198, 1171, 1205, 1142, 1217, 1140, 1157, 1128, 1119, 1114, 1185, 1147, 1166, 1147, 1149, 1178, 1168, 1160, 1154, 1142, 1166, 1220, 1152, 1167, 1191, 1143, 1132, 1200, 1132, 1176, 1149, 1140, 1140, 1148, 1136, 1104, 1168, 1201, 1173, 1183, 1146, 1155, 1211, 1160, 1176, 1151, 1149, 1142, 1165, 1178, 1206, 1184, 1161, 1181, 1128, 1178, 1142, 1148, 1159] Lung-AdenoCA SBS17a T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 2312.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS17a C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6261.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS17a C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6261.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS17a C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6261.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Panc-AdenoCA SBS17a T>A 304.0 254.0 289.61 281.99 0.21084437499581515 0.5133029473993337 8.912 6261.0 Lagging 1.197 1.027 1.165 1 304.0 289.61 262.0 315.0 [268, 269, 294, 267, 289, 288, 292, 290, 277, 305, 289, 298, 292, 279, 298, 299, 300, 266, 279, 305, 289, 282, 297, 296, 301, 275, 298, 309, 277, 279, 275, 299, 294, 291, 283, 278, 281, 277, 292, 315, 296, 282, 314, 271, 301, 275, 295, 291, 283, 278, 285, 303, 293, 300, 292, 262, 288, 284, 282, 298, 282, 292, 289, 297, 277, 293, 307, 304, 297, 280, 282, 284, 291, 288, 290, 286, 282, 296, 283, 269, 301, 294, 289, 292, 280, 285, 293, 304, 302, 296, 300, 294, 302, 285, 279, 310, 287, 294, 315, 285] 254.0 281.99 257.0 307.0 [302, 301, 276, 301, 281, 288, 273, 269, 287, 265, 279, 269, 293, 307, 265, 277, 279, 298, 289, 269, 287, 282, 276, 281, 268, 289, 271, 271, 303, 287, 295, 269, 265, 276, 279, 298, 298, 295, 284, 259, 282, 290, 258, 298, 276, 297, 270, 284, 298, 299, 287, 264, 271, 280, 281, 304, 290, 290, 296, 276, 292, 271, 276, 267, 285, 277, 270, 265, 274, 284, 293, 280, 285, 280, 288, 296, 286, 274, 281, 301, 280, 274, 285, 282, 286, 295, 281, 272, 275, 271, 283, 267, 266, 295, 294, 257, 291, 275, 268, 285] Panc-AdenoCA SBS17a T>C 2944.0 2759.0 2934.36 2851.54 0.3411305097093591 0.72999732820024 91.088 6261.0 Lagging 1.067 1.029 1.037 2944.0 2934.36 2813.0 3020.0 [2949, 2918, 2887, 2947, 2971, 2813, 2937, 2869, 2942, 2925, 2899, 2987, 2921, 2955, 2919, 2938, 2959, 2929, 2894, 2936, 2886, 2876, 2899, 2950, 2955, 2906, 2906, 2873, 2926, 2872, 2943, 3009, 2942, 2948, 2893, 2925, 2900, 3011, 2983, 2955, 2943, 2870, 2925, 2931, 2925, 2927, 2926, 2863, 2940, 2942, 2973, 2992, 2864, 2981, 3004, 2934, 2959, 2966, 2958, 2899, 2966, 2983, 2952, 2848, 2962, 2939, 2981, 2913, 3016, 2984, 2954, 2939, 2894, 2900, 2960, 2945, 2899, 2913, 2937, 3019, 2869, 2998, 2901, 2977, 2940, 2903, 2899, 2921, 2895, 2955, 2928, 3014, 2912, 2893, 2907, 2924, 2964, 2919, 3020, 3018] 2759.0 2851.54 2754.0 2962.0 [2800, 2855, 2919, 2852, 2826, 2914, 2817, 2906, 2875, 2848, 2866, 2822, 2869, 2800, 2864, 2850, 2861, 2873, 2848, 2814, 2938, 2923, 2891, 2846, 2827, 2883, 2866, 2897, 2869, 2913, 2845, 2781, 2865, 2852, 2905, 2874, 2867, 2789, 2804, 2833, 2833, 2899, 2897, 2847, 2847, 2856, 2860, 2928, 2863, 2891, 2780, 2836, 2903, 2799, 2781, 2841, 2830, 2834, 2881, 2880, 2811, 2786, 2801, 2962, 2807, 2820, 2754, 2905, 2791, 2810, 2858, 2824, 2896, 2905, 2816, 2841, 2900, 2890, 2840, 2783, 2917, 2793, 2843, 2827, 2828, 2864, 2864, 2855, 2905, 2818, 2845, 2804, 2879, 2893, 2924, 2856, 2852, 2811, 2787, 2756] Panc-AdenoCA SBS17a T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 6261.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS17a C>A 0.0 0.0 0.0 0.0 1.0 1.0 0.0 160634.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS17a C>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 160634.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS17a C>T 0.0 0.0 0.0 0.0 1.0 1.0 0.0 160634.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Stomach-AdenoCA SBS17a T>A 16115.0 15000.0 16074.19 15627.93 0.00648746354796656 0.02422029255222005 19.37 160634.0 Lagging 1.074 1.029 1.045 16115.0 16074.19 15870.0 16303.0 [16013, 16267, 15954, 15894, 16110, 16027, 16026, 15966, 15920, 16052, 16017, 16040, 15945, 16105, 16303, 16229, 16100, 16014, 16047, 16165, 16105, 16167, 16087, 16016, 15961, 16125, 16091, 16111, 15887, 16128, 15971, 16074, 16041, 16109, 16066, 16086, 16150, 16057, 15948, 16117, 16041, 15899, 15916, 15932, 16085, 15884, 16061, 15976, 16124, 16164, 16098, 16168, 16089, 16021, 16166, 16049, 16158, 16200, 16113, 16140, 16091, 16059, 16202, 16075, 16061, 16100, 15870, 16102, 16255, 16228, 16164, 15970, 16078, 15983, 16175, 16139, 16118, 16073, 16202, 16197, 15940, 16150, 16255, 15956, 16101, 16066, 16153, 15973, 16021, 16044, 15950, 16010, 16123, 16072, 16067, 16125, 16111, 16132, 16091, 16162] 15000.0 15627.93 15364.0 15832.0 [15630, 15508, 15768, 15757, 15581, 15683, 15637, 15702, 15752, 15681, 15698, 15683, 15751, 15637, 15364, 15480, 15704, 15680, 15643, 15522, 15568, 15464, 15483, 15669, 15709, 15590, 15599, 15574, 15804, 15425, 15701, 15684, 15672, 15551, 15623, 15677, 15605, 15687, 15771, 15647, 15676, 15825, 15763, 15722, 15606, 15800, 15555, 15696, 15523, 15616, 15594, 15514, 15581, 15666, 15689, 15610, 15516, 15560, 15598, 15652, 15485, 15736, 15591, 15618, 15617, 15655, 15832, 15621, 15492, 15547, 15516, 15635, 15534, 15779, 15509, 15551, 15600, 15553, 15513, 15506, 15770, 15484, 15491, 15662, 15633, 15629, 15615, 15779, 15683, 15642, 15798, 15673, 15556, 15633, 15612, 15565, 15727, 15572, 15661, 15592] Stomach-AdenoCA SBS17a T>C 67994.0 61525.0 66748.77 65033.8 3.6465645660561795e-21 3.114877260846628e-20 80.63 160634.0 Lagging 1.105 1.026 1.077 67994.0 66748.77 66429.0 67130.0 [66758, 66945, 66685, 66486, 67007, 66693, 66796, 66945, 66736, 66491, 66581, 66658, 66923, 66942, 66796, 66827, 66667, 66671, 66793, 66867, 66524, 66783, 66540, 66547, 66956, 66525, 66948, 66666, 66804, 66770, 66713, 66882, 66756, 67057, 66847, 66758, 66668, 66578, 66760, 66623, 66535, 66592, 66977, 66776, 66714, 67130, 66699, 66784, 66701, 66684, 66851, 66752, 67002, 66946, 66429, 66844, 66723, 66850, 66743, 66664, 66741, 66986, 66651, 66692, 66824, 66951, 66680, 66674, 66893, 66668, 66696, 66467, 66719, 66902, 66891, 66556, 66438, 66698, 66959, 66534, 66709, 66698, 66466, 66799, 66781, 66745, 66609, 66841, 66715, 66939, 66760, 66636, 66541, 66731, 66952, 66965, 66683, 66630, 66857, 66832] 61525.0 65033.8 64609.0 65478.0 [65073, 65024, 64993, 65268, 64999, 65044, 64896, 65022, 65042, 65478, 65192, 65244, 64883, 64856, 65076, 64848, 65133, 65107, 65071, 65147, 65276, 65123, 65330, 65157, 64834, 65123, 65013, 64995, 64883, 65025, 64943, 65001, 65039, 64768, 64882, 64828, 65188, 65136, 65076, 65055, 64978, 65290, 64733, 65128, 65002, 64732, 65049, 64884, 64914, 65118, 65030, 65148, 64802, 65089, 65170, 65010, 64867, 65006, 65015, 65013, 65056, 64609, 64991, 65127, 65069, 64778, 65047, 65070, 64854, 65152, 65138, 65176, 64947, 64828, 64831, 65252, 65273, 64993, 65055, 65134, 65078, 65095, 65355, 65197, 65086, 64933, 65207, 64914, 65131, 64849, 64981, 65195, 65118, 64976, 64956, 64954, 65153, 65075, 64842, 64856] Stomach-AdenoCA SBS17a T>G 0.0 0.0 0.0 0.0 1.0 1.0 0.0 160634.0 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] 0.0 0.0 0.0 0.0 [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0] Summary across all cancer types signature mutation_type strand fold_change_1.1 len(fold_change_1.1_cancer_types) fold_change_1.2 len(fold_change_1.2_cancer_types) fold_change_1.3 len(fold_change_1.3_cancer_types) fold_change_1.5 len(fold_change_1.5_cancer_types) fold_change_1.75 len(fold_change_1.75_cancer_types) fold_change_2+ len(fold_change_2+_cancer_types) all_cancer_types_list len(all_cancer_types_list) avg_fold_change SBS17a T>A Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Eso-AdenoCA', 'Lung-AdenoCA', 'Panc-AdenoCA', 'Stomach-AdenoCA'] 5 SBS17a T>C Lagging [] 0 [] 0 [] 0 [] 0 [] 0 [] 0 ['ESCC', 'Eso-AdenoCA', 'Lung-AdenoCA', 'Panc-AdenoCA', 'Stomach-AdenoCA'] 5