# Only cancer types with minimum 2000 mutations for SBS signatures with average probability at least 0.75 are considered. signature cancer_type processive_group_length number_of_processive_groups log10_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_number_of_processive_groups SBS17a Lung-AdenoCA 2 12 2.485 0.48 1.0 14.0 6.33 2.502 0.012434195805185096 0.01519735042855956 1.818 [7, 6, 3, 5, 6, 3, 7, 12, 10, 8, 5, 5, 8, 4, 12, 4, 7, 8, 6, 8, 6, 2, 9, 7, 6, 11, 3, 6, 7, 4, 5, 9, 8, 2, 5, 9, 2, 8, 4, 9, 1, 7, 2, 9, 6, 5, 12, 6, 2, 6, 5, 6, 6, 5, 11, 3, 7, 2, 6, 7, 7, 5, 4, 7, 6, 7, 7, 7, 4, 9, 4, 14, 4, 7, 10, 7, 4, 8, 6, 5, 8, 2, 6, 6, 8, 6, 6, 8, 5, 6, 7, 7, 10, 10, 8, 7, 4, 7, 3, 7] SBS17a Lung-AdenoCA 3 1 0.0 0.0 1.0 1.0 1.0 0.0 inf [1] SBS17a Panc-AdenoCA 2 48 3.871 0.48 8.0 28.0 18.67 3.803 1.1200063422200723e-14 1.6291001341382866e-14 13.788 [23, 21, 15, 17, 13, 15, 23, 13, 28, 19, 22, 13, 18, 26, 14, 18, 20, 8, 18, 19, 21, 21, 16, 25, 21, 18, 16, 21, 15, 21, 20, 19, 19, 16, 18, 21, 16, 13, 17, 17, 23, 15, 22, 22, 22, 20, 19, 22, 16, 13, 11, 20, 22, 14, 27, 13, 13, 17, 13, 16, 22, 15, 19, 13, 20, 15, 24, 20, 20, 22, 23, 15, 21, 16, 27, 21, 19, 17, 18, 22, 22, 21, 17, 19, 19, 18, 24, 22, 17, 15, 22, 20, 24, 16, 21, 17, 19, 14, 23, 14] SBS17a Panc-AdenoCA 3 1 0.0 0.0 1.0 1.0 1.0 0.0 inf [1, 1, 1, 1] SBS17a Stomach-AdenoCA 2 2655 7.884 0.48 1207.0 1427.0 1291.67 36.459 2.592443968029883e-300 1.0369775872119531e-299 298.984 [1276, 1345, 1235, 1312, 1284, 1302, 1335, 1281, 1337, 1240, 1313, 1279, 1350, 1349, 1271, 1354, 1362, 1346, 1273, 1292, 1287, 1328, 1301, 1226, 1278, 1255, 1293, 1237, 1351, 1299, 1290, 1306, 1328, 1296, 1310, 1287, 1264, 1266, 1309, 1316, 1251, 1207, 1306, 1237, 1288, 1288, 1317, 1250, 1299, 1296, 1252, 1294, 1267, 1262, 1245, 1256, 1303, 1267, 1273, 1236, 1272, 1277, 1270, 1227, 1221, 1271, 1255, 1333, 1277, 1316, 1319, 1329, 1334, 1367, 1345, 1270, 1297, 1306, 1427, 1283, 1247, 1300, 1280, 1294, 1263, 1284, 1297, 1327, 1285, 1295, 1329, 1300, 1257, 1287, 1256, 1283, 1323, 1299, 1291, 1317] SBS17a Stomach-AdenoCA 3 92 4.522 0.275 8.0 28.0 18.03 4.577 6.351580398200692e-58 1.4227540091969548e-57 56.847 [24, 21, 14, 16, 25, 19, 21, 20, 10, 15, 15, 18, 16, 20, 13, 14, 17, 12, 23, 19, 17, 13, 20, 21, 18, 16, 25, 17, 17, 11, 17, 15, 23, 23, 23, 25, 11, 22, 13, 14, 13, 15, 24, 18, 19, 14, 14, 26, 24, 21, 26, 18, 15, 14, 16, 10, 10, 8, 19, 17, 16, 19, 22, 20, 23, 13, 21, 15, 17, 10, 13, 16, 19, 24, 10, 21, 19, 24, 17, 19, 23, 16, 15, 14, 27, 28, 21, 16, 15, 20, 18, 25, 24, 13, 16, 24, 15, 23, 13, 25] SBS17a Stomach-AdenoCA 4 5 1.609 0.098 1.0 2.0 1.167 0.373 1.2790683300820107e-23 2.2383695776435187e-23 22.65 [1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 2] SBS17a Eso-AdenoCA 2 8537 9.052 0.48 3617.0 3924.0 3770.26 59.23 0.0 0.0 inf [3770, 3849, 3866, 3808, 3747, 3806, 3668, 3706, 3656, 3684, 3757, 3765, 3755, 3737, 3793, 3776, 3762, 3853, 3791, 3729, 3749, 3754, 3814, 3762, 3797, 3763, 3769, 3791, 3763, 3808, 3745, 3779, 3810, 3760, 3678, 3742, 3710, 3818, 3700, 3847, 3822, 3642, 3791, 3813, 3800, 3695, 3809, 3834, 3634, 3716, 3804, 3777, 3802, 3873, 3784, 3838, 3649, 3818, 3876, 3617, 3910, 3842, 3715, 3824, 3802, 3770, 3772, 3746, 3801, 3757, 3801, 3801, 3737, 3784, 3774, 3769, 3728, 3755, 3840, 3712, 3708, 3792, 3844, 3744, 3787, 3772, 3765, 3784, 3787, 3712, 3835, 3667, 3924, 3758, 3828, 3766, 3817, 3650, 3708, 3707] SBS17a Eso-AdenoCA 3 318 5.762 0.306 39.0 86.0 57.55 8.548 3.2986366198346465e-200 5.314470109733597e-200 199.275 [60, 66, 62, 60, 42, 43, 52, 57, 49, 62, 58, 63, 55, 51, 86, 54, 66, 56, 49, 51, 49, 70, 53, 63, 54, 39, 57, 61, 68, 48, 49, 57, 69, 62, 61, 57, 66, 55, 51, 67, 59, 62, 61, 49, 50, 57, 67, 64, 64, 42, 67, 66, 62, 56, 66, 74, 68, 65, 56, 73, 58, 44, 40, 51, 46, 67, 64, 70, 53, 55, 58, 74, 48, 45, 68, 52, 56, 61, 61, 46, 60, 60, 44, 55, 48, 53, 66, 57, 62, 59, 43, 57, 52, 48, 55, 62, 67, 49, 57, 58] SBS17a Eso-AdenoCA 4 19 2.944 0.156 1.0 4.0 1.534 0.742 1.2371924229977293e-119 1.7085038222349596e-119 118.767 [2, 1, 3, 2, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 2, 3, 1, 1, 2, 1, 2, 1, 2, 2, 2, 1, 1, 1, 2, 1, 2, 1, 2, 1, 1, 2, 1, 1, 3, 4, 3, 1, 1, 2, 1, 1, 1, 1, 2, 1, 3, 1, 3, 1, 1, 2, 1, 1, 1, 2, 3, 1, 1, 1, 2, 1, 2, 3, 1] SBS17a Eso-AdenoCA 5 2 0.693 0.037 1.0 1.0 1.0 0.0 0.0 0.0 inf [1, 1] SBS17a ESCC 2 25 3.219 0.48 4.0 22.0 11.14 3.432 3.1943288673957563e-05 4.7914933010936355e-05 4.32 [15, 15, 15, 16, 16, 11, 12, 13, 11, 12, 5, 9, 13, 12, 6, 7, 9, 12, 5, 8, 14, 9, 11, 17, 8, 13, 7, 11, 17, 13, 10, 14, 11, 14, 22, 13, 13, 11, 15, 13, 8, 10, 11, 10, 12, 17, 11, 10, 8, 11, 4, 10, 11, 4, 13, 12, 8, 18, 12, 10, 6, 8, 17, 9, 12, 14, 10, 12, 9, 8, 9, 9, 10, 13, 12, 7, 8, 12, 14, 16, 11, 7, 15, 4, 9, 9, 21, 9, 9, 9, 10, 14, 8, 12, 12, 11, 7, 10, 9, 15] signature cancer_type processive_group_length avg_number_of_processive_groups log10_avg_number_of_processive_groups radius min_sims max_sims mean_sims std_sims pvalue qvalue minus_log10_qvalue expected_avg_number_of_processive_groups SBS17a ACROSS_ALL_CANCER_TYPES 2 2255.4 3.353 0.48 976.2 1061.0 1019.614 13.7 0.0 0.0 inf [1018.2, 1047.2, 1026.8, 1031.6, 1013.2, 1027.4, 1009.0, 1005.0, 1008.4, 992.6, 1020.4, 1014.2, 1028.8, 1025.6, 1019.2, 1031.8, 1032.0, 1045.4, 1018.6, 1011.2, 1015.4, 1022.8, 1030.2, 1007.4, 1022.0, 1012.0, 1017.6, 1013.2, 1030.6, 1029.0, 1014.0, 1025.4, 1035.2, 1017.6, 1006.6, 1014.4, 1001.0, 1023.2, 1009.0, 1040.4, 1021.0, 976.2, 1026.4, 1018.2, 1025.6, 1005.0, 1033.6, 1024.4, 991.8, 1008.4, 1015.2, 1021.4, 1021.6, 1031.6, 1016.0, 1024.4, 996.0, 1024.4, 1036.0, 977.2, 1043.4, 1029.4, 1005.0, 1016.0, 1012.2, 1015.4, 1013.6, 1023.6, 1022.2, 1022.4, 1031.2, 1033.6, 1021.2, 1037.4, 1033.6, 1014.8, 1011.2, 1019.6, 1061.0, 1007.6, 999.2, 1024.4, 1032.4, 1013.4, 1017.2, 1017.8, 1022.6, 1030.0, 1020.6, 1007.4, 1040.6, 1001.6, 1044.6, 1016.6, 1025.0, 1016.8, 1034.0, 996.0, 1006.8, 1012.0] SBS17a ACROSS_ALL_CANCER_TYPES 3 103.0 2.013 0.288 14.25 25.25 19.395 2.17 0.0 0.0 inf [21.5, 22.25, 19.5, 19.5, 17.25, 16.0, 18.75, 19.75, 15.25, 19.75, 18.75, 20.75, 18.25, 18.25, 25.25, 17.5, 21.25, 17.5, 18.5, 18.0, 17.0, 21.25, 18.75, 21.5, 18.5, 14.25, 21.0, 20.0, 21.75, 15.25, 17.0, 18.5, 23.5, 21.75, 21.5, 21.0, 19.75, 19.75, 16.5, 20.75, 18.5, 19.75, 21.75, 17.25, 17.75, 18.25, 20.75, 23.0, 22.5, 16.25, 23.75, 21.5, 19.75, 18.0, 21.0, 21.5, 20.0, 18.75, 19.25, 23.0, 19.0, 16.25, 16.0, 18.25, 17.75, 20.5, 21.75, 21.75, 18.0, 16.75, 18.25, 23.0, 17.25, 17.75, 20.0, 18.75, 19.25, 21.75, 20.0, 16.75, 21.25, 19.5, 15.25, 17.75, 19.25, 20.75, 22.25, 18.75, 19.75, 20.25, 15.75, 21.0, 19.5, 15.75, 18.25, 22.0, 21.0, 18.5, 18.0, 21.25] SBS17a ACROSS_ALL_CANCER_TYPES 4 12.0 1.079 0.154 1.0 2.583 1.35 0.315 4.05888544231057e-246 4.05888544231057e-246 245.392 [1.5, 1.0, 2.0, 1.5, 1.5, 1.5, 1.0, 1.5, 1.0, 1.0, 1.0, 1.5, 1.0, 1.0, 1.0, 1.5, 1.0, 1.0, 1.5, 2.0, 1.5, 1.0, 1.5, 1.0, 1.5, 1.0, 1.5, 1.5, 1.5, 1.5, 1.083, 1.083, 1.583, 1.083, 1.583, 1.083, 1.583, 1.083, 1.083, 1.583, 1.083, 1.083, 2.083, 2.583, 2.083, 1.083, 1.083, 1.583, 1.083, 1.083, 1.083, 1.083, 1.583, 1.083, 2.083, 1.083, 2.083, 1.083, 1.083, 1.583, 1.083, 1.083, 1.083, 1.583, 2.083, 1.083, 1.083, 1.083, 1.583, 1.083, 1.583, 2.083, 1.083, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35, 1.35] SBS17a ACROSS_ALL_CANCER_TYPES 5 2.0 0.301 0.043 1.0 1.0 1.0 0.0 0.0 0.0 inf [1.0, 1.0]